CN103749981A - Application of protocatechuic acid as feed additive in livestock breeding - Google Patents
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Abstract
The invention provides application of protocatechuic acid as a feed additive in livestock breeding, the protocatechuic acid is used for promoting the growth and development of animals, improving the feed conversion rate, improving ketone body quality and meat quality, comprehensively enhancing animal immunization function and capacity of preventing disease; the toxic and side effect of chemically synthesized organic acid and food potential risk are overcome, the disadvantages that the Chinese herbal medicine additives are complex in component, the use is inconvenient, and the quality standard is hard to control are avoided, the research and development prospect is positive, and the clinical application is wide.
Description
Technical field
The invention belongs to field of veterinary, be specifically related to protocatechuic acid application in livestock and poultry cultivation as feed addictive.
Background technology
Along with the fast development of aquaculture and feed industry, people progressively recognize: in animal feed, add antibiotic, hormone, chemical classes synthetic drug can promote growth of animal, reduce disease generation, but the use for a long time of these medicines can make pathogenic microorganism produce drug resistance, product medicament residue and environmental pollution etc., serious threat human health affects the outlet of China's agricultural byproducts simultaneously.
Nearly more than ten years, along with the forbidding of European Union's feeding antibiotic, have been accelerated the research and development of AGP (growth promotion antibiotic) substitute.And organic acid is effect stability, security good, the most promising rear antibiotic epoch growth promoter.Organic acid is the general designation of some acidic organic compounds, how water-soluble or ethanol.Feed refers generally to seven carbon following (comprising seven carbon), SCFA with one or more hydroxy-acid groups with organic acid.
Organic acid can improve pepsin activity, is the physiological regulation agent of stomach power and gastric emptying, and exocrine in the pancreas of pig, sheep and calf is had to spread effect.It can make feed distribute distinctive fragrance, stimulates taste bud emiocytosis saliva, improves animal feed intake.Organic acid can directly or indirectly promote intestinal epithelial cell to grow by affecting small intestine microorganism fermentation pattern (ratio between SCFA), improves intestinal structure, enhanced machine body Nutrient Absorption.The organic acid pig of feeding, the digestibility of nitrogen improves, and the discharge capacity of ammonia reduces.Organic acid also has chelation, can be used as the metal ions such as part and calcium, phosphorus, copper, iron, zinc and forms the higher complex of biological value, thereby be conducive to the absorption of rear portion enteron aisle to these mineral elements.
Organic acid can promote the increment of alimentary canal beneficial bacterium Bacillus acidi lactici and Bifidobacterium, suppresses pathogen Escherichia coli and staphylococcic growth, reduces Incidence of Diarrhea.It is by activating host's immune system, and induction produces antibacterial peptide; By lipopolysaccharides in the outer membrane component of depolymerization, cause epicyte permeability to increase; In born of the same parents, organic acid dissociates proton and acid ion, pumps process and the bacterial growth competition energy of proton outside born of the same parents; Acid ion is stoping hereditary information transmission and destroy in born of the same parents the aspect generation effects such as osmotic pressure balance.Visible organic acid is in a variety of forms to pathogen growth performance inhibitory or killing effect.But the application of existing organic acid mostly is chemical synthesis, cost is higher and have a side effect.
Chinese herb feed additive just with the mode of action of its uniqueness, good result, noresidue, without the resistance to the action of a drug and pollution-free and become a kind of desirable feed addictive.China has abundant Chinese herbal medicine resource, should accelerate the research and development to it, makes brand with Chinese characteristics.To solving the antibiotic residue problem of long-term puzzlement animal husbandry development, development stockbreeding industry, meets the demand of people to food security, strengthens the competitiveness of China's livestock products in international market, has important economic implications and social benefit.
But at present, generally bigger than normal, the transportation inconvenience of Chinese herb feed additive using dosage, palatability are poor, to suitability for industrialized production, bring inconvenience.Most formulations are take powder or decoction as main, and refined type is few, lacks effective quality standard and examination criteria.
Protocatechuic acid (protocatechuic acid, PCA)
Another name: PCA
CAS：[99-50-3]
Molecular formula: (HO)
2c
6h
3cOOH
Molecular weight: 154.12
Character: white to brown crystalline powder, variable color in air.Density 1.54g/cm3.Approximately 200 ℃ of fusing points (decomposition).Be dissolved in 50 parts of water; Be dissolved in ethanol, ether.
Plant origin: the leaf that is present in Lindsaeaceae plant Stenoloma chusana [Stenoloma chusanum (L) Ching], in the plants such as the leaf of holly plant Chinese ilex (Ilex chi-nensis Sims), be also one of active ingredient of the Chinese medicines such as grass-leaved sweetflag, fructus alpiniae oxyphyllae.
Pharmacological effect: there is anti-platelet aggregation, reduce the effects such as MCO, inhibiting bacteria and diminishing inflammation, mediation apoptosis of tumor cells and neuroprotective.
But author of the present invention finds that by great many of experiments protocatechuic acid has the effect that promotes animal growth and improve body's immunity, did not disclose protocatechuic acid and have the effect that promotes animal growth and improve body's immunity in prior art.There is no protocatechuic acid application in livestock and poultry cultivation as feed addictive substitute antibiotics yet.
Summary of the invention
The problem existing for solving above-mentioned prior art, the present invention proposes protocatechuic acid application in livestock and poultry cultivation as feed addictive, for promoting growing of animal, improve food conversion ratio, improve carcass quality and meat flavor, strengthen the ability of Immune Function In Animals and defence disease comprehensively, chemical synthesis organic acid toxic and side effect and food security hidden danger have been overcome, avoid Chinese herb feed additive complicated component, used inconvenience, quality standard to be difficult to the deficiencies such as control, Prospect of R & D optimism, clinical practice is wide.
For achieving the above object, technical scheme of the present invention is:
Protocatechuic acid is the application in livestock and poultry cultivation as feed addictive, and described application refers to that protocatechuic acid is promoting growing of animal, the application of the aspect of improving food conversion ratio as feed addictive.
Protocatechuic acid is the application in livestock and poultry cultivation as feed addictive, and described application refers to that protocatechuic acid is strengthening the ability of Immune Function In Animals with defence disease as feed addictive.
Further, described livestock and poultry comprise pig, ox, sheep, chicken, duck, goose.
Further, described protocatechuic acid contains protocatechuic acid by all plant and microorganism separation and Extraction obtain.
Further, described protocatechuic acid is 1: 100 as the mass ratio of feed addictive and feed interpolation.
With respect to prior art, beneficial effect of the present invention is: the present invention proposes protocatechuic acid application in livestock and poultry cultivation as feed addictive, for promoting growing of animal, improve food conversion ratio, improve carcass quality and meat flavor, strengthen the ability of Immune Function In Animals and defence disease comprehensively, chemical synthesis organic acid toxic and side effect and food security hidden danger have been overcome, avoid Chinese herb feed additive complicated component, used inconvenience, quality standard to be difficult to the deficiencies such as control, Prospect of R & D optimism, clinical practice is wide.
The specific embodiment
Below in conjunction with specific embodiment, the present invention program is described in further detail:
Embodiment 1, protocatechuic acid is the application in piglet cultivation as feed addictive.
Basis diet is provided by Nanjing He Jia Ji Sheng agriculture and animal husbandry Development Co., Ltd, and basic diet composition and trophic level are in Table 1.China's pharmaceutical biological product identifies that the protocatechuic acid that provides and citric acid, as feed addictive, all with basic diet mix in mass ratio at 1: 100, carries out piglet in vivo studies.
The basic diet composition of table 1 and trophic level (air bells dry basis)
30 healthy regular grade " Du × large × long " three way cross weanling pig, 50 ages in days, purchased from test pig farm, Agricultural University Of Nanjing Jiangpu.After conforming, be divided at random 3 groups, 10 every group, male and female half and half.Feed respectively and do not add the basal diet (control group) of the basal diet (blank group) of protocatechuic acid, the basal diet (experimental group) that adds protocatechuic acid 1% and interpolation lactic acid 1%.28 days experimental periods.
1d and last 1d 8:00 in morning respectively at test weigh on an empty stomach, according to initial weight and last re-computation average daily gain.Average daily gain=head is net gain/test number of days all.Record the feed intake of piglet, calculate average daily feed intake, after off-test, calculate material anharmonic ratio.Material anharmonic ratio=average daily feed intake/average daily gain.The average daily gain that found that blank group is 484.22g, and the average daily gain of experimental group is 558.35g, and both differences are extremely remarkable, and the average daily gain of control group is 527.24g.The average daily feed intake of blank group is 835.72g, and the average daily feed intake of experimental group is 1088.10g, and both differences are extremely remarkable, and the average daily feed intake of control group is 956.75g.The material anharmonic ratio of blank group is 1.74, and the material anharmonic ratio of experimental group is 1.96, both significant differences, and the material anharmonic ratio of control group is 1.83.Experimental result explanation protocatechuic acid can significantly promote the daily gain of piglet, and on the palatability of feed, without any impact, the increase of feed intake is relevant with the raising of piglet digestion power.Expect that anharmonic ratio declines simultaneously, illustrate that growth of animal performance obviously improves, nutritional status is good.
Test the vena cava anterior blood sampling on an empty stomach in early morning of last 1d piglet, enzyme linked immunosorbent assay detects content, little intestine trilobate factor (TFF3) and superoxide dismutase (SOD) activity of Immunoglobulin in Serum.The serum IgG content that found that blank group is 1.47mg/mL, and the IgG content of experimental group is 1.87mg/mL, and both differences are extremely remarkable, and the IgG content of control group is 1.55mg/mL.The serum IgM content of blank group is 0.58mg/mL, and the IgM content of experimental group is 0.77mg/mL, both significant differences, and the IgM content of control group is 0.68mg/mL.The serum T FF3 content of blank group is 15.92ng/mL, and the TFF3 content of experimental group is 19.03ng/mL, and both differences are extremely remarkable, and the TFF3 content of control group is 16.31ng/mL.The SOD in serum content of blank group is 9.24ng/mL, and the SOD content of experimental group is 11.35ng/mL, both significant differences, and the SOD content of control group is 10.82ng/mL.Experimental result explanation protocatechuic acid can significantly raise the level of piglet IgG, and it is the highest immunoglobulin (Ig) of content in animal blood serum, accounts for the 75%-80% of immunoglobulin (Ig) total amount, is the main force of anti-infectious immunity.Protocatechuic acid by improving body IgM level, affects humoral immune reaction simultaneously, thus enhanced machine body immunity function, the generation of prevention epidemic disease.The main Physiological Function of TFF3 is that the gastrointestinal tract mucous epithelium of protection is avoided exogenous factor attack, and Epithelial restitution and regeneration after damage, tests visible protocatechuic acid and shows positive mucosal barrier and defense function, is beneficial to control intestinal inflammatory.SOD level can reflect body cell and be subject to the order of severity of free radical attack and the ability of body removing free radical, and protocatechuic acid can reduce the generation of peroxidation, by suppressing the lipid oxidation of muscle, participates in regulation and control carcass quality and meat flavor.
Test the vena cava anterior blood sampling on an empty stomach in early morning of last 1d piglet, automatic clinical chemistry analyzer detects blood parameters.The Total albumen content of blank group is 61.93g/L, and the total protein content of experimental group is 74.55g/L, and both differences are extremely remarkable, and the total protein content of control group is 69.68g/L.The serum albumin levels of its empty group is 31.22g/L, and the albumin content of experimental group is 35.83g/L, both significant differences, and the albumin content of control group is 34.67g/L.The serum urea level of blank group is 3.75mmol/L, and the urea level of experimental group is 2.86mmol/L, and both differences are extremely remarkable, and the urea level of control group is 3.16mmol/L.The serum total cholesterol level of blank group is 2.27mmol/L, and the total cholesterol level of experimental group is 1.83mmol/L, and both differences are extremely remarkable, and the total cholesterol level of control group is 2.18mmol/L.The serum triglyceride level of blank group is 0.37mmol/L, and the triglyceride levels of experimental group is 0.29mmol/L, both significant differences, and the triglyceride levels of control group is 0.31mmol/L.Experimental result explanation protocatechuic acid can raise body total protein and albuminous level, and they have represented trophic level and the digest and assimilate degree of animal to protein of protein in daily ration, and prompting protocatechuic acid has increased liver metabolism function.Protocatechuic acid can reduce the urea level of body, this means proteins deposited increase, amino acid balance ideal.Protocatechuic acid can be lowered body T-CHOL and content of triglyceride, illustrates that animal strengthens fatty decomposition, has accelerated metabolic speed, enhancing development.
The above is the preferred embodiments of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of principle of the present invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Experimental example 2: the impact of protocatechuic acid on growth of meat chicken and immune performance, trunk and meat quality
1, animal used as test:
Experimental animal AA broiler chicken is purchased in broiler breeding base, Nanjing, 1 Japanese instar chickling, and conventional raising after 21 ages in days, chooses 270 of the healthy broiler chicken that body weight is close.
2, Experimental agents:
Basis diet adopts corn-soybean meal diet, and with reference to NRC (1994) feeding of broiler standard design formula, feedstuff composition is with reference to Chinese feed nutrient table (2010).Its concrete formula and trophic level are in Table 2.
The basic diet composition of table 2 and trophic level (air bells dry basis)
Broiler chicken full price commercial feed is purchased from domestic certain feed factory.China's pharmaceutical biological product identifies that the protocatechuic acid that provides and citric acid, as feed addictive, all with basic diet mix in mass ratio at 1: 100.
3, experiment grouping:
270 plumage 21 aa broiler chicken are divided into blank group, experimental group and 3 processed group of control group at random, feed respectively and do not add the basal diet (control group) of the basal diet (blank group) of protocatechuic acid, the basal diet (experimental group) that adds protocatechuic acid 1% and interpolation lactic acid 1%.Establish 3 repetitions for every group, 30 of each repetitions, the group mesosome method of double differences different not remarkable (P > 0.05) before test.
4, experimental technique:
Adopt single factor completely randomized experiment design.Experimental period,, from broiler chicken 22 age in days to 49 ages in days, amounts to 28 days.Feeding and management is carried out according to < < AA meat chick feeding and management handbook > >.Test chicken is raised in three layers of stacked metal cage, free choice feeding and drinking-water, and natural lighting, humidity 65% left and right, well-ventilated, keeps hygienically clean.By AA meat chick conventional program, carry out immunity.
5, experimental index:
5.1 growth performances are measured
Animal, by the grouping of experimental design scheme, is weighed before formal test, for testing just starting weight, when off-test, weighs on an empty stomach, heavy for end, calculates average daily gain.Record every group of feed consumption, calculate feedstuff-meat ratio.Average daily gain=(end weight-initial weight)/number of days, feedstuff-meat ratio=daily ingestion amount/daily gain.
5.2 Slaughters are measured
After broiler chicken 49 ages in days are weighed, randomly draw 8 test chickens (male and female half and half) for every group and butcher, weigh collare venesection execution and wet hair pull out method.< < performance of poultry index name and computational methods > > that between dressing percentage, complete clean thorax rate, half clean thorax rate, chest muscle rate, leg flesh rate, abdomen fat rate, subcutaneous fat thickness and leg flesh flesh, fatty width measurements method is formulated by the national poultry breeding committee carry out.
5.3 immune indexes are measured
After butchering, get Immune Organs of Chichen, the bursa of farbricius, spleen, reject fat around and take fresh weight, calculate Immune Organs Index: bioplasm amount before Immune Organs Index/(g/kg)=immune organ quality/government official.While butchering, with venous blood collection under disposable syringe wing, IgA, the IgG in serum and IgM adopt immunoglobulin A & G & M immunity turbidimetry kit to detect.
5.4 chicken meat qualities are measured
Crude protein, is used Micro-kjoldahl method to measure.Crude fat, is used soxhlet extraction to measure.PH value, measures with pH S-2 type precision acidity meter, and after chicken kills, the same time in 1h is cut two osculums on carcass chest muscle, and electrode insertion is surveyed its pH value immediately.Yellowish pink, is used the full-automatic colour examining color difference meter of TC-PIIG type to measure.Shearing force, makes CLM-3 type tender degree device, will after meat slaking to 70 ℃, measure.Inosinicacid takes off the right about 10g in chest muscle middle part in 5min after butchering, use high performance liquid chromatograph to measure.Drip loss, gets size and weighs for the chest muscle meat sample of 5.0cm × 3.0cm × 2.0cm, and muscle fibre is hung in the polythene film bag of inflation vertically downward, weighs after preserving 24h at 4 ℃.Cooking loss is water-bath slaking meat to 70 ℃ mensuration for the rear 24h of sampling.
6, data processing:
Test data adopts the one-way ANOVA process in SPSS17.0 statistical software to carry out variance analysis, and DuncanShi method is carried out multiple ratio, and take P<0.05 as the level of signifiance, test data represents with " average ± standard deviation ".
7, experimental result:
7.1 growth performance determination experiments the results are shown in Table 3.
The impact of table 3 protocatechuic acid on growth of meat chicken performance
Note: the female different significant differences (P < 0.05) that represent of the data of going together shoulder marking-up, indicate same letter and represent not remarkable (P > 0.05) of difference; Lower same.
Body weight is to weigh a grow important indicator of degree and colony's uniformity of poultry.In Broiler Dietary, add 1% protocatechuic acid, can promote growth of animal, reduce feedstuff-meat ratio.The average daily gain of experimental group and eventually last counterpoise are significantly higher than control group, show fast growth, may be that protocatechuic acid has improved intestinal environment flora ratio, promote profitable strain growth, and the absorption of material at small intestine has additional nutrients.The material anharmonic ratio of experimental group is significantly lower than control group, and the protocatechuic acid liquid secretion that stimulates digestion, strengthens gastrointestinal peristalsis, helps to improve digestive function and the price of deed.
7.2 Slaughter determination experiments the results are shown in Table 4.
The impact of table 4 protocatechuic acid on broiler chicken Slaughter
Slaughter is to weigh the important indicator of producing meat economic performance, and high-quality chicken dressing percentage is generally in 85%～91% scope.Protocatechuic acid passes through to change the Endogenous Hormones of chicken, promotes that myocyte's protein is synthetic, reduces the degraded of protein, the dressing percentage of raising chicken and chest muscle, leg flesh rate.The dressing percentage of experimental group and chest muscle, leg flesh rate are all significantly higher than control group, and the impact of chest muscle is greater than to the impact on leg flesh.Protocatechuic acid has the lipocatabolic effect of promotion, suppresses the deposition of body fat.In this test, add protocatechuic acid the complete clean thorax rate of animal and half clean thorax rate are had no significant effect, but reduced fatty width between abdomen fat rate, subcutaneous fat thickness and leg flesh flesh, reduced the especially deposition of leg flesh fat of muscle.Belly is the main position of broiler chicken fat deposition, and the abdomen fat of broiler chicken is about 22% of total amount of body fat.Between abdomen fat rate, subcutaneous fat thickness and the leg flesh flesh of experimental group, fatty width is all significantly lower than control group.
7.3 immune system determination experiments the results are shown in Table 5.
Table 5 protocatechuic acid is on the immune impact of broiler chicken
The growth of immune organ directly affects the immunologic function of body, it is generally acknowledged being reduced to due to immunosupress of immune organ weight, otherwise is that immunity strengthens.Animal immune organ weight's increase be by himself Growth of Cells grow and division growth due to, this result of the test shows, the interpolation of protocatechuic acid can make broiler chicken thymus gland, spleen, bursa of farbricius index all be significantly higher than control group, they grow and rapidly ripe, can make broiler chicken resist various cause pathogeny imcrobe infections and stress ability be improved.Although experimental group is not remarkable to IgA content influence and control group comparing difference, IgM and IgG content are all significantly increased than control group.The function of cellular immunity and humoral immunity is added protocatechuic acid and can be promoted in explanation in daily ration, little on mucosal immunity impact.
7.4 meat quality determination experiments the results are shown in Table 6.
The impact of table 6 protocatechuic acid on Meat Quality of Broiler Chicks
Index crude protein and the crude fat of conventional evaluation meat nutritional labeling, have a direct impact the apparent proterties of meat, and this experiment protocatechuic acid has upregulated protein level to muscle, lowers the effect of fat content.PH value is muscle acidity visualize, and its decrease speed also can affect protein solubility and the bacterial reproduction speed of meat.The pH value of experimental group is significantly higher than control group.When pH raises, percentage of water loss reduces, and is that waterpower increases, and pH and shearing force are roughly negative correlation.Shearing force is lower, and the fresh and tender degree of muscle is better.The shearing force of experimental group is significantly lower than control group.In muscle, the content of inosinicacid is the main component that forms muscle delicate flavour, relevant to essential amino acids content in muscle.The imp content of experimental group is significantly higher than control group, and cooking loss is significantly lower than control group.Reason may be that in experimental group muscle, cholesterol level is relatively low, and between flesh, fat content is on the low side, and the Free water in meat is relatively less, simultaneously with the water of protein bound to more, and then cooking loss is reduced.Drip loss can to muscle be that water characteristic is evaluated, drip loss is lower, is that waterpower is higher.The drip loss of experimental group is also significantly lower than control group.
8, experiment conclusion:
Organic acid adds composition as novel fodder and starts to apply in animal production in 20 end of the centurys, and obtains positive effect.Plant extracts class feed addictive is considered to the feed addictive of " safety, efficient, stable, controlled ".Protocatechuic acid, in conjunction with both advantages, can significantly promote animal growth, promotes production performance and economic worth, improves immune status and resistance against diseases, improves carcass quality, ensures food safety.Being expected to become animal foodstuff produces and the vigorous new source of economic growth of feed industry.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention is not limited to this, and any variation of expecting without creative work or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (5)
1. protocatechuic acid application in livestock and poultry cultivation as feed addictive, is characterized in that, described application refers to that protocatechuic acid is promoting growing of animal, the application of the aspect of improving food conversion ratio as feed addictive.
2. protocatechuic acid application in livestock and poultry cultivation as feed addictive, is characterized in that, described application refers to that protocatechuic acid is strengthening Immune Function In Animals and defending the application aspect disease ability as feed addictive.
3. application as claimed in claim 1 or 2, is characterized in that, described livestock and poultry comprise pig, ox, sheep, chicken, duck, goose.
4. application as claimed in claim 1 or 2, is characterized in that, the plant that described protocatechuic acid contains protocatechuic acid by all and microorganism separation and Extraction obtain.
5. application as claimed in claim 1 or 2, is characterized in that, described protocatechuic acid is 1: 100 as the mass ratio of feed addictive and feed interpolation.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616394A (en) * | 2016-02-25 | 2016-06-01 | 河南科技学院 | Application of protocatechuic acid to improving immune function of livestock |
| CN109007355A (en) * | 2018-08-10 | 2018-12-18 | 佛山市三水区嘉信农业技术研究院（普通合伙） | A kind of functional feed improving malnutritional anemia |
| CN110574838A (en) * | 2019-09-02 | 2019-12-17 | 湖南农业大学 | Weaned piglet feed |
| CN111494312A (en) * | 2020-05-20 | 2020-08-07 | 山东省健牧生物药业有限公司 | Oral liquid for preventing and treating chicken colibacillosis and preparation method thereof |
| CN111543558A (en) * | 2020-05-11 | 2020-08-18 | 四川铁骑力士实业有限公司 | Nutrition enhancer for improving production performance of laying hens after forced moulting |
| CN111887375A (en) * | 2020-07-31 | 2020-11-06 | 中国农业大学 | Application of protocatechuic acid in antagonism of feed fumonisins |
| CN114052144A (en) * | 2021-12-07 | 2022-02-18 | 青岛大学附属医院 | Traditional Chinese medicine feed additive for improving growth performance of animals and preparation method thereof |
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| JP2012240996A (en) * | 2011-05-24 | 2012-12-10 | Ina Food Industry Co Ltd | Immunopotentiator and antiallergic agent, and food, cosmetic, quasi drug and animal feed containing the same |
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| US3425838A (en) * | 1965-02-18 | 1969-02-04 | Takeda Chemical Industries Ltd | Artificial feedstuff for silkworm larvae containing a hydroxybenzaldehyde compound |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616394A (en) * | 2016-02-25 | 2016-06-01 | 河南科技学院 | Application of protocatechuic acid to improving immune function of livestock |
| CN109007355A (en) * | 2018-08-10 | 2018-12-18 | 佛山市三水区嘉信农业技术研究院（普通合伙） | A kind of functional feed improving malnutritional anemia |
| CN110574838A (en) * | 2019-09-02 | 2019-12-17 | 湖南农业大学 | Weaned piglet feed |
| CN111543558A (en) * | 2020-05-11 | 2020-08-18 | 四川铁骑力士实业有限公司 | Nutrition enhancer for improving production performance of laying hens after forced moulting |
| CN111494312A (en) * | 2020-05-20 | 2020-08-07 | 山东省健牧生物药业有限公司 | Oral liquid for preventing and treating chicken colibacillosis and preparation method thereof |
| CN111887375A (en) * | 2020-07-31 | 2020-11-06 | 中国农业大学 | Application of protocatechuic acid in antagonism of feed fumonisins |
| CN111887375B (en) * | 2020-07-31 | 2022-05-10 | 中国农业大学 | Application of protocatechuic acid in antagonism of feed fumonisins |
| CN114052144A (en) * | 2021-12-07 | 2022-02-18 | 青岛大学附属医院 | Traditional Chinese medicine feed additive for improving growth performance of animals and preparation method thereof |
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Application publication date: 20140430 |