CN103739640A - 一种甜菊糖a苷晶体及其制备方法和用途 - Google Patents
一种甜菊糖a苷晶体及其制备方法和用途 Download PDFInfo
- Publication number
- CN103739640A CN103739640A CN201410044560.7A CN201410044560A CN103739640A CN 103739640 A CN103739640 A CN 103739640A CN 201410044560 A CN201410044560 A CN 201410044560A CN 103739640 A CN103739640 A CN 103739640A
- Authority
- CN
- China
- Prior art keywords
- stevioside
- crystal formation
- crystal
- glycosides
- degrees
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 title claims abstract description 158
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- 229940013618 stevioside Drugs 0.000 title claims abstract description 94
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 title claims abstract description 94
- 229930182470 glycoside Natural products 0.000 title claims abstract description 48
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- 239000001512 FEMA 4601 Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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- 238000001237 Raman spectrum Methods 0.000 description 2
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 2
- 241000544066 Stevia Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
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- 239000002994 raw material Substances 0.000 description 2
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- 239000012064 sodium phosphate buffer Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- ONVABDHFQKWOSV-UHFFFAOYSA-N 16-Phyllocladene Natural products C1CC(C2)C(=C)CC32CCC2C(C)(C)CCCC2(C)C31 ONVABDHFQKWOSV-UHFFFAOYSA-N 0.000 description 1
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- 241000189115 Catananche Species 0.000 description 1
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410044560.7A CN103739640B (zh) | 2014-01-30 | 2014-01-30 | 一种甜菊糖a苷晶体及其制备方法和用途 |
US15/115,542 US20170051002A1 (en) | 2014-01-30 | 2014-06-27 | Rebaudioside A Crystal And Its Preparation Method And Use |
PCT/CN2014/080909 WO2015113370A1 (zh) | 2014-01-30 | 2014-06-27 | 一种甜菊糖a苷晶体及其制备方法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410044560.7A CN103739640B (zh) | 2014-01-30 | 2014-01-30 | 一种甜菊糖a苷晶体及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN103739640A true CN103739640A (zh) | 2014-04-23 |
CN103739640B CN103739640B (zh) | 2016-08-17 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410044560.7A Active CN103739640B (zh) | 2014-01-30 | 2014-01-30 | 一种甜菊糖a苷晶体及其制备方法和用途 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20170051002A1 (zh) |
CN (1) | CN103739640B (zh) |
WO (1) | WO2015113370A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015113370A1 (zh) * | 2014-01-30 | 2015-08-06 | 诸城市浩天药业有限公司 | 一种甜菊糖a苷晶体及其制备方法和用途 |
CN105693791A (zh) * | 2016-03-24 | 2016-06-22 | 诸城市浩天药业有限公司 | 甜菊双糖苷晶型a、其制备方法、食品组合物及应用 |
WO2018166475A1 (zh) | 2017-03-16 | 2018-09-20 | 诸城市浩天药业有限公司 | 甜菊糖m苷晶型及制备方法和用途 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3033243A1 (en) * | 2016-08-09 | 2018-02-15 | Dsm Ip Assets B.V. | Crystallization of steviol glycosides |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101472487A (zh) * | 2006-06-19 | 2009-07-01 | 可口可乐公司 | 甜菊双糖苷a组合物及其纯化方法 |
WO2010118218A1 (en) * | 2009-04-09 | 2010-10-14 | Cargill, Incorporated | Sweetener composition comprising high solubility form of rebaudioside a and method of making |
CN102770436A (zh) * | 2009-12-31 | 2012-11-07 | 可口可乐公司 | 莱鲍迪苷a组合物和纯化莱鲍迪苷a的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101270138B (zh) * | 2007-03-23 | 2011-05-04 | 宁波绿之健药业有限公司 | 一种高含量甜菊糖a3甙的提取方法 |
CN100500685C (zh) * | 2007-08-01 | 2009-06-17 | 江南大学 | 一种从甜菊糖中提取高纯度莱鲍迪a甙的方法 |
CN102286041A (zh) * | 2011-08-25 | 2011-12-21 | 辽宁千千生物科技有限公司 | 一种用重结晶提纯甜菊糖甙的方法 |
CN103739640B (zh) * | 2014-01-30 | 2016-08-17 | 诸城市浩天药业有限公司 | 一种甜菊糖a苷晶体及其制备方法和用途 |
-
2014
- 2014-01-30 CN CN201410044560.7A patent/CN103739640B/zh active Active
- 2014-06-27 WO PCT/CN2014/080909 patent/WO2015113370A1/zh active Application Filing
- 2014-06-27 US US15/115,542 patent/US20170051002A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101472487A (zh) * | 2006-06-19 | 2009-07-01 | 可口可乐公司 | 甜菊双糖苷a组合物及其纯化方法 |
WO2010118218A1 (en) * | 2009-04-09 | 2010-10-14 | Cargill, Incorporated | Sweetener composition comprising high solubility form of rebaudioside a and method of making |
CN102770436A (zh) * | 2009-12-31 | 2012-11-07 | 可口可乐公司 | 莱鲍迪苷a组合物和纯化莱鲍迪苷a的方法 |
Cited By (6)
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WO2015113370A1 (zh) * | 2014-01-30 | 2015-08-06 | 诸城市浩天药业有限公司 | 一种甜菊糖a苷晶体及其制备方法和用途 |
CN105693791A (zh) * | 2016-03-24 | 2016-06-22 | 诸城市浩天药业有限公司 | 甜菊双糖苷晶型a、其制备方法、食品组合物及应用 |
WO2017161987A1 (zh) * | 2016-03-24 | 2017-09-28 | 诸城市浩天药业有限公司 | 甜菊双糖苷晶型及制备方法和用途 |
CN105693791B (zh) * | 2016-03-24 | 2018-12-28 | 诸城市浩天药业有限公司 | 甜菊双糖苷晶型a、其制备方法、食品组合物及应用 |
WO2018166475A1 (zh) | 2017-03-16 | 2018-09-20 | 诸城市浩天药业有限公司 | 甜菊糖m苷晶型及制备方法和用途 |
US11059843B2 (en) | 2017-03-16 | 2021-07-13 | Zhucheng Haotian Pharm Co., Ltd. | Stevioside M crystal form, preparation method therefor and use thereof |
Also Published As
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WO2015113370A1 (zh) | 2015-08-06 |
CN103739640B (zh) | 2016-08-17 |
US20170051002A1 (en) | 2017-02-23 |
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