CN103736060B - Lumbago plaster and preparation method thereof - Google Patents
Lumbago plaster and preparation method thereof Download PDFInfo
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- CN103736060B CN103736060B CN201410011319.4A CN201410011319A CN103736060B CN 103736060 B CN103736060 B CN 103736060B CN 201410011319 A CN201410011319 A CN 201410011319A CN 103736060 B CN103736060 B CN 103736060B
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Abstract
The invention discloses a preparation method of a lumbago plaster, which is prepared from rhubarb, dried ginger, rhizoma kaempferiae, costus root, cortex periplocae, radix angelicae pubescentis, sandalwood, radix angelicae dahuricae, paniculate swallowwort root, ligusticum wallichii, clove, caulis kadsurae, teasel root, radix cyathulae and auxiliary materials; the lumbago plaster has the effects of diminishing inflammation, easing pain, warming and recuperating kidney yang, dispelling wind and relieving pain and the like, has exact curative effect on rheumatism lumbago, lumbar muscle strain, vertebra, spinal cord and other diseases, combines medicament treatment with physical therapy, and has the beneficial effects of quick response, good curative effect, less using amount of penetration enhancer and small side effect.
Description
Technical field
The present invention relates to a kind of lumbago plaster and preparation method thereof, belong to the field of medicine technology.
Technical background
Lumbago is the disease that outpatient service is common, and the people of 80% can meet with lumbago, and in lumbago crowd
The people of 24%～87% there will be lumbago recurrence in 1 year.Lumbago is with waist one or both sides pain as cardinal symptom
A kind of disease.The kidney disease of doctor trained in Western medicine, rheumatism, lumbar muscle strain, vertebra and diseases of spinal cord etc. are caused, many
For chronic strain and and and aseptic inflammation cause.The traditional Chinese medical science thinks that pain in the lumbar region pain is many by insufficiency of kidney-YANG, cold coagulation dai channel,
Or dampness-heat of the liver is invaded and dai channel, when row, yang deficiency gas is weak, so that dai channel is depressed obstructed and pain occurs;Or
Punching appoints a QI and blood to fill Sheng, so that dai channel is stopped up stagnant, and damp and hot delay and pain.Therapeutic Method primarily now includes guarding
With two kinds of methods of operation, concrete can be divided into pharmacotherapy (oral pain alleviating or nonsteroidal anti inflammatory analgesic
Thing), physiotherapy, minimally-invasive treatment, traditional operation.The simple local anaesthesia drug injection of the most a lot of employing and local anaesthesia
Medicine and placebo, but research show, about chronic back pain patient 60% after injection 3～4 months the most invalid.
Radio-frequency (RF) ablation, intervertebral disc laser or interior electrothermal therapy, the application etc. of chamber mirror technology can substantially reduce because opening
The wound that operation brings, is accepted by increasing patient.But, because the requirement of patient for treatment is not
With, the impact in the visual field of operation own and the restriction that enters passage, and operation can bring wound all the time, treats
It is not very convenient.Therefore, a clear curative effect, rapidly, the less preparation of side effect will be subject to deeply in effect
Welcome.
Summary of the invention:
The technical problem to be solved is to provide a kind of lumbago plaster and preparation method thereof.Described lumbago plaster
There is the effects such as antiinflammatory, analgesia, warming and recuperating the kidney-YANG, wind-expelling pain-stopping.For treatment lumbago due to pathogenic wind-dampness, lumbar muscle strain,
The disease such as vertebra and spinal cord has definite curative effect.
For solving above-mentioned technical problem, the present invention realizes by the following technical solutions:
A kind of lumbago plaster, calculates according to composition by weight, it by Radix Et Rhizoma Rhei 100-200 part, Rhizoma Zingiberis 50-120 part,
Rhizoma Kaempferiae 20-80 part, Radix Aucklandiae 10-30 part, Cortex Periplocae 10-30 part, Radix Angelicae Pubescentis 10-50 part, Lignum Santali Albi 10-30 part,
Radix Angelicae Dahuricae 20-80 part, Radix Cynanchi Paniculati 20-80 part, Rhizoma Chuanxiong 10-30 part, Flos Caryophylli 10-30 part, Caulis et Radix Periplocae Forrestii 20-80
Part, Radix Dipsaci 10-50 part, Radix Cyathulae 10-50 part are first made drug extract, then are prepared from adjuvant.
Specifically, described lumbago plaster according to composition by weight calculate, it by Radix Et Rhizoma Rhei 160 parts, Rhizoma Zingiberis 80 parts,
Rhizoma Kaempferiae 56 parts, the Radix Aucklandiae 20 parts, Cortex Periplocae 20 parts, Radix Angelicae Pubescentis 32 parts, 20 parts of Lignum Santali Albi, the Radix Angelicae Dahuricae 56 parts, slowly
Long minister in ancient times 56 parts, Rhizoma Chuanxiong 20 parts, Flos Caryophylli 20 parts, Caulis et Radix Periplocae Forrestii 64 parts, Radix Dipsaci 32 parts, 32 parts of elder generations of Radix Cyathulae
Make drug extract, then be prepared from adjuvant.
Aforesaid lumbago plaster, calculates according to composition by weight, and it is by described drug extract 2-6 part, SIS-818
10-20 part, SBS-8115-10 part, C5 are hydrogenated with 20-40 part, naphthenic rubber oil 4-12 part, far infrared
Powder 0.5-1 part, magnetic powder 5-10 part, antioxidant YD1680.2-0.8 part, antioxidant YD10100.1-0.5
Part, potassium sorbate 0.05-0.2 part, penetrating agent 2-7 part are prepared from.
Specifically, aforesaid lumbago plaster, according to composition by weight calculate, it by described drug extract 4 parts,
SIS-81814 part, SBS-8117 part, C5 are hydrogenated with 30 parts, naphthenic rubber oil 8 parts, far-infrared powder 0.88
Part, magnetic powder 7.5 parts, antioxidant YD1680.67 part, antioxidant YD10100.33 part, potassium sorbate
0.1 part, penetrating agent 5 parts is prepared from.
Penetrating agent calculates according to components by weight percent, by Borneolum Syntheticum 6 parts, Mentholum 13 parts, natural camphor 6 parts, water
Poplar acid methyl ester 4 parts, azone 15 parts are mixed with and form.
Described lumbago plaster is external patch unguentum；
Carrier material used by described lumbago plaster is non-woven fabrics or release paper.
Described drug extract is prepared: take the medical material of recipe quantity, is ground into coarse powder, adds percolate pot, adds
The 3-5 times amount 80%-95% ethanol of medical material amount, Jiang Guankou obturages, and infiltrates 24-72 hour, impregnates complete, receives
Just filter liquid, due-in must put into amount of alcohol 60-70% time；Put into the ethanol of 4-8 times amount 80%-95% of medical material amount,
Put into point 3-5 time, receive liquid of filtering, due-in must put into ethanol total amount 70%-85% time by valve wide open, put only,
When reclaiming ethanol and be concentrated into 60 DEG C, relative density is the extractum of 1.14-1.16, filters while hot, receives cream, i.e.
?.
Specifically, described drug extract is prepared: take the medical material of recipe quantity, is crushed to the coarse powder of 40 mesh,
Place backing net, be sequentially added into percolate pot by leaf, powder, the order of stem, and consolidated with wooden stick, by medical material amount
4 times amount 90% ethanol sprinkles on the medical material of percolate pot, 30 mesh stainless (steel) wires are placed on medical material uniformly
Weighting material, obturages filling mouth with Polypropylence Sheet and sealing compound, infiltrates 48 hours, impregnates complete, by every kilogram of medicine
Liquid of just filtering received by material per minute 3～5mL, due-in must put into amount of alcohol 60-70% time；Put into medical material amount successively
The ethanol of 6 times amount 90%, add in four times, each 1.5 times, by every kilogram of medical material per minute 3～5mL
Receipts are filtered liquid, due-in must put into ethanol total amount 80% time by valve wide open, put clean, with the concentration of spherical recovered under reduced pressure
Tank reclaims ethanol and is concentrated into the extractum that 60 DEG C of relative densities are 1.14～1.16, filters with 200 mesh filter screens while hot
Cross, receive cream, to obtain final product.
Described external patch unguentum is prepared: be hydrogenated with by C5, naphthenic rubber oil is put into heating in reactor and stirred
Mixing 1-3 hour, add SIS-818, SBS-811 and stir 4-6 hour, period temperature all controls at 130-140
DEG C, add antioxidant YD168, antioxidant YD1010, far-infrared powder, magnetic powder, stir 1-3 hour, then
It is sequentially added into potassium sorbate, drug extract, stirs 30-80 minute, add penetrating agent, stir 5-20 minute,
Coating, section, to obtain final product.
Specifically, described external patch unguentum is prepared: be hydrogenated with by C5, reaction put into by naphthenic rubber oil
Heated and stirred 2 hours in still, add SIS-818, SBS-811 and stir 5 hours, and period temperature all controls
130-140 DEG C, adding antioxidant YD168, antioxidant YD1010, far-infrared powder, magnetic powder, stirring 2 is little
Time, sequentially add potassium sorbate, drug extract, stir 50 minutes, add penetrating agent, stir 10 minutes,
Coating, section, to obtain final product.
Lumbago plaster of the present invention by Radix Et Rhizoma Rhei, Rhizoma Zingiberis, Rhizoma Kaempferiae, the Radix Aucklandiae, Cortex Periplocae, Radix Angelicae Pubescentis, Lignum Santali Albi, the Radix Angelicae Dahuricae,
Radix Cynanchi Paniculati, Rhizoma Chuanxiong, Flos Caryophylli, Caulis et Radix Periplocae Forrestii, Radix Dipsaci, Radix Cyathulae and adjuvant are prepared from.Radix Et Rhizoma Rhei bitter in the mouth in side,
Cold, warm in nature, heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.Amass for excess-heat
Stagnant constipation, heat in blood is told nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, is fallen
Beat damage, hygropyretic dysentery, yellow cellulitis dark coloured urine, stranguria, edema；Externally treating burns and scalds.Modern pharmacology proves Radix Et Rhizoma Rhei tool
There is antiinflammatory action.Rhizoma Zingiberis is pungent, heat.Return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warm
Lung dissipating fluid-retention effect.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and cold fluid-retention is breathed with cough.Modern pharmacology proves dry
Rhizoma Zingiberis Recens has the pharmacological actions such as antalgic and inflammation relieving, antitumor, antipathogen.Rhizoma Kaempferiae acrid in the mouth, warm in nature.Return stomach warp.Have
Circulation of qi promoting warming middle-JIAO, helps digestion, the function of pain relieving.For chest and diaphragm distension, coldness and pain in the epigastrium, diet does not disappears.The Radix Aucklandiae is pungent,
Hardship, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.There are promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion function.Coerce for breast,
Abdominal distention, weight after dysentery, food stagnation does not disappears, anorexia.Modern pharmacology prove the Radix Aucklandiae have anthelmintic, antibacterial,
Analgesic biological activity.Cortex Periplocae is pungent, bitter, temperature；Poisonous.Return liver, kidney, heart channel.There is inducing diuresis to remove edema,
Wind-damp dispelling, the function such as bone and muscle strengthening.Float the middle of the month for lower limb, shortness of breath and palpitation, anemofrigid-damp arthralgia, soreness of the waist and knees.Solely
Pungent, the bitter in the mouth of activity, tepor.Return kidney, bladder warp.There are expelling wind and removing dampness, numbness relieving and pain relieving function.Wet for wind and cold
Numbness, lumbocrural pain, few the moon volt wind headache, wind and cold holds wet headache under the arm.Lignum Santali Albi nature and flavor are pungent, temperature.Return spleen, stomach, the heart,
Lung meridian.Tool circulation of qi promoting warming middle-JIAO, pain relieving of whetting the appetite.For QI stagnated by cold, chest and diaphragm does not relaxes, obstruction of qi in the chest and cardialgia, epigastric pain,
Vomiting lack of appetite.The Radix Angelicae Dahuricae is pungent, taste temperature.Return stomach, large intestine, lung meridian.There is relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, a surname
Clearing the nasal passage, dampness leukorrhagia stopping, the function of detumescence and apocenosis.For headache due to common cold, eyebrow shuttle osteodynia, watery nasal discharge of having a stuffy nose, nose
Having a stuffy nose, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.Modern pharmacology proves have easing pain and diminishing inflammation, activating blood circulation to dissipate blood stasis, solution
Convulsion, scattered wind (trembling with fear), the pharmacological action of dehumidifying.Radix Cynanchi Paniculati nature and flavor are pungent, temperature.Return liver, stomach warp.Tool dispels the wind,
Removing dampness, pain relieving, antipruritic effect.For rheumatic arthralgia, distension of having a stomachache, toothache, lumbago. fall and flutter the pain of injury,
Rubella, eczema etc..There is the pharmacological actions such as anti-inflammatory and antalgic, venom, antitumor.Rhizoma Chuanxiong acrid in the mouth, warm in nature.
Return liver, gallbladder, pericardium channel.There is the merits such as blood-activating and qi-promoting, wind-expelling pain-stopping.For obstruction of qi in the chest and cardialgia, breast coerces twinge,
Tumbling and swelling, menoxenia, amenorrhea dysmenorrhea, the diseases such as abdominal mass is suffered from abdominal pain, and has a headache, rheumatic arthralgia.Flos Caryophylli property is pungent,
Temperature.Return spleen, stomach, lung, kidney channel.There are warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG function.For Deficiency and coldness of spleen and stomach, singultus is vomitted
Tell, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.Caulis et Radix Periplocae Forrestii has the merit stimulated the menstrual flow, invigorate blood circulation, detoxify, dispel the wind
Effect, cures mainly the diseases such as rheumatic arthritis, traumatic injury, menoxenia, is that among the people being widely used in treats closure
The diseases such as soft tissue injury, rheumatism and rheumatoid.There is anticancer, the effect of antalgic and inflammation relieving, heart tonifying.Radix Dipsaci taste
Bitter, sweet, pungent, tepor, return liver, kidney channel.There is invigorating the liver and kidney, promoting the circulation of blood arteries and veins, effect of reuniting the fractured tendons and bones；For waist
Knee joint soreness, rheumatism fraud pain, traumatic injury, fracture swells and ache.Radix Cyathulae sweet in the mouth, micro-hardship, flat.Return liver, kidney channel.
Have the functions such as eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea abdominal mass, retention of placenta, injury from falling down,
Rheumatic arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, the disease such as hematuria stranguria with blood.The present invention by common for said medicine prescription, play altogether antiinflammatory,
Analgesia, warming and recuperating the kidney-YANG, effect of wind-expelling pain-stopping.For treatment lumbago due to pathogenic wind-dampness, lumbar muscle strain, vertebra and spinal cord
Definite curative effect is had etc. disease.
Owing to emplastrum is percutaneous drug administration preparation, medicine need to penetrate into body by keratodermatitis etc., produces and makees
With, therefore general onset time is longer, generally uses addition penetrating agent to promote drug osmotic.But it is general
Chemical enhancers has certain side effect, and life-time service may cause skin uncomfortable, and lumbago plaster of the present invention exists
Adjuvant adds far-infrared powder and magnetic powder, the far infrared that far-infrared powder produces also known as " life light wave ", with
The frequency of vibration of human inner cell's molecule is close, after its infiltration is internal, will cause the atom of human body cell
With the resonance of molecule, through resonant absorption, between molecule, frictional heat forms thermal response, promotes subcutaneous deep temperature
Degree rises, and makes Marjoram Extract, accelerates blood circulation, can promote the absorption of medicine, reduces penetrating agent and uses
Amount.
It addition, after lumbago plaster of the present invention adds far-infrared powder and magnetic powder in adjuvant, far infrared is deep and thorough
Power, up to muscle arthrosis depths, makes body interior warm, relaxs one's muscles, and drives oxygen and the nutrient of capillary network
Exchange, and it is interior swollen to eliminating to get rid of the accumulation aging refuse such as internal fatigue substances and lactic acid, relaxes the effect ached
Fruit is remarkable.Specific electromagnetic wave spectrum (TDP) wavelength that magnetic powder produces is at 2-25 micron, it is easy to biological
Body absorbs, and is free from side effects.The biological effect useful to biology can also be produced, thus improve in organism
The activity of various enzymes, improves the microcirculqtory system in organism, improves and transfer the immunologic function of organism self,
Produce more immunity body fluid, alleviate pain.Far-infrared powder can promote the quick of medicine with magnetic powder simultaneously
Absorb, improve the utilization rate of medicine, so that lumbago plaster onset of the present invention is rapid, good effect.
Compared with prior art, the present invention with the Radix Et Rhizoma Rhei of antalgic and inflammation relieving, Rhizoma Zingiberis, Rhizoma Kaempferiae, the Radix Aucklandiae, Radix Cynanchi Paniculati,
The Cortex Periplocae of wind-expelling pain-stopping, Rhizoma Chuanxiong, Radix Cyathulae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Heiguteng exract, help with the Radix Dipsaci of warming the kidney to activate YANG,
Lignum Santali Albi, Flos Caryophylli composition.Both it had been good at chronic strain and lumbago that aseptic inflammation causes, and had been good at again treating caused by rheumatism
Arthralgia pain.We add far-infrared powder and magnetic powder in adjuvant simultaneously, the far infrared that far-infrared powder produces
Deep and thorough power, up to muscle arthrosis depths, makes body interior warm, relaxs one's muscles, drive capillary network oxygen and
Nutrient exchanges, and it is interior swollen to eliminating to get rid of the accumulation aging refuse such as internal fatigue substances and lactic acid, and mitigation is ached
Effect remarkable, far infrared can make subcutaneous deep skin temperature rise simultaneously, expands blood capillary, promotion blood
The infiltration of liquid circulation, beneficially medicine and utilization.The specific electromagnetic wave spectrum that magnetic powder produces is easy to by organism
Absorb, produce biological useful biological effect, thus the activity of various enzymes in improving organism, improve biology
Internal microcirculqtory system, improves and transfers the immunologic function of organism self, produces more immunity body fluid,
Diminish inflammation and pain.
Applicant carried out following experiments, the provable present invention has effective effect；
Experimental example 1:
Medicine of the present invention uses 90% ethanol to be Extraction solvent, and inventor finds through Related Experimental Study, uses cold
Leaching method is extracted, ethanol large usage quantity, extracts not exclusively, uses percolation to extract, has ethanol consumption less,
Extract the advantage such as more completely.Use outside the lumbago plaster that lumbago plaster adjuvant prescription of the present invention and production technology are produced
Sight, viscosity, uniformity etc. are preferable.
1, substrate is preferred
The evaluation methodology of 1.1 emplastrum substrate
With indexs such as outward appearance, viscosity, stretchability, uniformity, fissilities, made emplastrum substrate is carried out comprehensively
Evaluate: outward appearance should be the paste that dilute denseness is suitable；Viscosity is with skin as experimental subject, and stickiness should be bigger；Tu Zhan
Property should be prone to coating；When uniformity should be coated with on non-woven fabrics consistent without granular sensation, exquisiteness, thin and thick；Fissility
Then reply plastic covering film is easily peeled, does not sticks.All items is evaluated by index quality, full marks 20 points,
Defective is 5 points, and obatained score summation is comprehensive grading.
The optimization of 1.2 emplastrum substrate prescriptions
According to emplastrum prescription and principal agent characteristic, select C5 hydrogenation, naphthenic rubber by experiment of single factor
Oil, SIS-818 and SBS-811 are substrate constituent, inventor is hydrogenated with C5, naphthenic rubber is oily,
SIS-818 and SBS-811 is investigation factor, and each factor sets 3 levels, and factor level is shown in Table 1, selects
L9(34) orthogonal table experiment arrangement, it being divided into the preferred purifying process of index with general comment, result see table 2.
Table 1 factor level table
Table 2 orthogonal array
Analyze conclusion: be divided into index with general comment, table 4 intuitively analyzing and can obtaining optimum extraction process is A1B2C3D2,
Extreme difference size is RD>RC>RA>RB, i.e. C5 is hydrogenated with > and SIS-818 > SBS-811 > naphthenic rubber oil, determine base
Matter is: SBS-8117g, naphthenic rubber oil 8g, SIS-81814g, C5 are hydrogenated with 30g.
2, penetrating agent consumption is investigated
2.1 emodin contents measure
Chromatographic condition and system suitability: octadecylsilane chemically bonded silica is filler；With methanol-0.1%
Phosphoric acid solution (85:15) is flowing phase；Detection wavelength is 254nm.Number of theoretical plate presses the calculating of rheum emodin peak should not
Less than 3000.
The preparation of reference substance solution: it is appropriate that precision weighs rheum emodin reference substance, adds methanol and is respectively prepared every lmL and contains
The each 80 μ g solution of rheum emodin, to obtain final product.
Algoscopy: precision draws reference substance solution and each 10 μ L of need testing solution respectively, injects chromatograph of liquid,
Measure, to obtain final product.
2.2 test sample skin permeation rates measure: the lumbago plaster of the present invention of same homalographic and blank patch are affixed on 2 respectively
Opening pretreated Corium Mus surface, patch powder is installed on transdermal diffusion experiment instrument towards supply chamber, and acceptable solution is
Normal saline.Set bath temperature as (37 ± 0.5) DEG C, mixing speed 100r/min, respectively at the 2nd,
4,6,8,12 and 24h sampling, with blank patch acceptable solution as blank, is measured by " 5.3.1 ", calculates
Transdermal enters the content of the rheum emodin in absorption cell, and is calculated as follows test sample skin permeation rate, and skin permeation rate (%)=
Rheum emodin in absorption cellARheum emodin total amount × 100% in content/lumbago plaster.
2.3 result
Add the most commensurability penetrating agent to affect rheum emodin skin permeation rate such as table 3:
Table 3 rheum emodin skin permeation rate
2.4 conclusions: as seen from the above table, rheum emodin skin permeation rate increases with penetrating agent consumption and increases, works as penetrating agent
After consumption is more than 5g, rheum emodin skin permeation rate is almost unchanged, therefore penetrating agent consumption is 5g.
Experimental example 2: pharmacodynamic study
1, laboratory animal: Kunming kind Strains of Mouse (20 ± 2g) is female, Sprague Dawley (SD) strain is big
Mus (150 ± 20g) is male, and two kinds of animals are purchased from Chongqing City's Experimental Animal Center.
2, Experimental agents:
2.1 invention formulation 1: prepare according to the method for embodiment 1 and embodiment 2.
2.2 invention formulation 2: prepare according to the method for embodiment 1 and embodiment 2, but without infrared
Powder and magnetic powder.
2.3 former technique preparations:
2.3.1 extract drugs
Prescription: Radix Et Rhizoma Rhei 160g, Rhizoma Zingiberis 80g, Rhizoma Kaempferiae 56g, Radix Aucklandiae 20g, Cortex Periplocae 20g, Radix Angelicae Pubescentis 32g,
Lignum Santali Albi 20g, Radix Angelicae Dahuricae 56g, Radix Cynanchi Paniculati 56g, Rhizoma Chuanxiong 20g, Flos Caryophylli 20g, Caulis et Radix Periplocae Forrestii 64g, Radix Dipsaci 32g,
Radix Cyathulae 32g.
Technique: take the medical material of recipe quantity, is crushed to the coarse powder of 40 mesh, places backing net, by leaf, powder,
The order of stem is sequentially added in extraction pot, adds 6 times amount 90% ethanol of medical material amount, with Polypropylence Sheet and sealing compound
Being obturaged by filling mouth, infiltrate 48 hours, filter, filtering residue adds 4 times amount 90% ethanol, infiltrates 48 hours, filters,
Merging filtrate.Reclaim ethanol with spherical recovered under reduced pressure concentration tank and be concentrated into relative density 1.14～1.16(60 DEG C),
Filter with 200 mesh filter screens, receive cream, to obtain final product.
2.3.2 prepared by preparation
Formula: drug extract 4g, mixed-matrix (rubber: Colophonium: zinc oxide: lanoline: vaseline=5:7:
6:1:1) 32g, penetrating agent (Borneolum Syntheticum: Mentholum: natural camphor: methyl salicylate: azone=6:13:6:
4:15) 5g, far-infrared powder 0.88g, magnetic powder 7.5g.
Technique: take Borneolum Syntheticum, Mentholum, natural camphor, methyl salicylate, azone mix according to prescription ratio
Penetrating agent is made in conjunction, standby；Separately take recipe quantity rubber, clean, at 50～60 DEG C of heat dryings or dry, cut
Become bulk, plasticate in rubber mixing machine and reticulate thin slice, eliminate electrostatic 18～after 24 hours, be dipped in appropriate gasoline,
Move to after swelling in adhesive supplier, stir evenly, add by several times vaseline, lanoline, zinc oxide, Colophonium, the reddest
Outer powder and magnetic powder make substrate, add the drug extract and penetrating agent made, stir evenly, and are coated with cream, reclaim vapour
Oil, lid lining, section, to obtain final product.
3, experimental technique
3.1 impacts on mice analgesic activity
3.1.1 mice is placed in special glass cylinder by experimental technique and result, and front half body is movable, rat-tail by
After Tong, stopper one pomegranate passes, after mice peace and quiet, survey pain.Survey mice bitterly at l/3 under afterbody as pain spot,
Alignment light tapping, stopwatch record irradiates the time of whipping as the threshold of pain from starting.Filtering out the response time exists
The animal of 3～12 seconds 40, be divided at random 4 groups (blank group, invention formulation 1 group, this
2 groups of bright preparation, former technique preparation group).Each treated animal makees the method around rat-tail adhesive plaster in addition to blank group
It is administered, after being administered, within 2,4,6,8 hours, throws off cream sheet measure the threshold of pain, measure.The results are shown in Table 4.
The table 4 impact (n=10, x ± s) on mice analgesic activity
Note: compare with blank group: * P ＜ 0.05, * * P ＜ 0.01.
Compare with former technique preparation group: #P ＜ 0.05.
Compare with the present invention 2 groups: △ P ＜ 0.05.
3.1.2 conclusion
Above experimental studies results shows, invention formulation 1 group, invention formulation 2 groups, former technique preparation group
All all can increase the mice threshold of pain；Wherein invention formulation 1 group, invention formulation 2 groups, all than former technique system
Agent group onset faster, better efficacy.And after being administered 6 hours, invention formulation 1 group is than invention formulation 2
Group better efficacy.
3.2 Ovum Gallus domesticus album to be caused the impact of inflammation
3.2.1 experimental technique and result take rat 40, are divided into 4 groups of (blank group, bases at random
1 group of invention preparation, invention formulation 2 groups, former technique preparation group), at the sufficient plantar subcutaneous injection lOO% of Mus hind leg
After Ovum Gallus domesticus album 0.05ml causes inflammation, make immediately around rat-tail adhesive plaster.Survey respectively by capillary tube measurement by magnification method
The volume of 1,2,4 hours sufficient sole of the foots before determining medicine, after medicine, observes the impact on its swelling degree of each group of plaster.Knot
Fruit is shown in Table 5.
Table 5 causes the impact (n=10, x ± s) of inflammation to Ovum Gallus domesticus album
Note: compare with blank group: * P ＜ 0.05, * * P ＜ 0.01.
Compare with former technique preparation group: #P ＜ 0.05.
Compare with the present invention 2 groups: △ P ＜ 0.05.
3.2.2 conclusion
Above experimental studies results shows, invention formulation 1 group, invention formulation 2 groups, former technique preparation group
All can alleviate the swelling effect caused by Ovum Gallus domesticus album；Wherein invention formulation 1 group, invention formulation 2 groups, all
Than former technique preparation group onset more faster, better efficacy.And after being administered 4 hours, invention formulation 1 group is than this
2 groups of better efficacy of bright preparation.
Experimental example 3: performance study
1 far infrared wavelength test takes invention formulation 10, removes lid lining, checks with far infrared detector,
A length of 10 μm of invention formulation far infrared wave～14 μm, emissivity is 85.7%.
2 magnetic induction tests take invention formulation 10, remove lid lining, measure, and invention formulation is
A little bigger magnetic induction is 0.82Gs.
(being compared with former technique preparation by invention formulation, invention formulation technique is with real in 3 viscosity tests
Execute example 1 and embodiment 2；The preparation method of former technique preparation is shown in experimental example 2).
The mensuration holding viscous force is measured by " Chinese Pharmacopoeia " 2010 editions one annex Ⅹ II E emplastrum adhesive force
The method mensuration of viscous force (second method hold) measures, and the results are shown in Table 6；
Peel strength is by " Chinese Pharmacopoeia " 2010 editions one annex Ⅹ II E emplastrum adhesive force algoscopy (the
The mensuration of three method peel strengths) measure, the results are shown in Table 6.
Table 6 viscosity
Conclusion: invention formulation all meets the requirements with former technique preparation viscosity, and the most primary bright formulation viscosity is relatively
Greatly, peel off relatively difficulty, will more greatly to skin group zest, and the stickiness of invention formulation is moderate, mastic
Plasticity is preferable, and affinity is strong, less to skin irritation.
Invention formulation (is compared, invention formulation technique by 4 irritation tests with former technique preparation
With embodiment 1 and embodiment 2；The preparation method of former technique preparation is shown in experimental example 2).
20 professionals please carry out blank sensation scoring, hundred-mark system, take geometrical mean.
Table 7 sensory evaluation scores reference listing
Invention formulation group is marked such as table 8 with former technique preparation group:
Table 8 irritation test is marked
Conclusion: invention formulation compares with former technique preparation, and invention formulation is less to the zest of skin.
Compared with prior art, lumbago plaster of the present invention have onset rapidly, good effect, penetrating agent usage amount
The beneficial effect such as less, side effect is less, Drug therapy combines with physics physical therapy.Applicant used reality in the past
Test the preparation method of " former technique preparation " in example 2 to be prepared, but use side of the present invention instead in March, 2012
Method prepares lumbago plaster, and in March, 2013, income from sales adds 29% the most on year-on-year basis.Reach goal of the invention.
Detailed description of the invention:
Embodiment 1: the preparation of drug extract
Prescription: Radix Et Rhizoma Rhei 160g, Rhizoma Zingiberis 80g, Rhizoma Kaempferiae 56g, Radix Aucklandiae 20g, Cortex Periplocae 20g, Radix Angelicae Pubescentis 32g,
Lignum Santali Albi 20g, Radix Angelicae Dahuricae 56g, Radix Cynanchi Paniculati 56g, Rhizoma Chuanxiong 20g, Flos Caryophylli 20g, Caulis et Radix Periplocae Forrestii 64g, Radix Dipsaci 32g,
Radix Cyathulae 32g.
Preparation technology: take the medical material of recipe quantity, is crushed to the coarse powder of 40 mesh, places backing net, by leaf,
Powder, the order of stem are sequentially added into percolate pot, and consolidate with wooden stick, by 4 times amount 90% ethanol sprinkles of medical material amount
On the medical material of percolate pot, 30 mesh stainless (steel) wires are placed on uniform weighting material on medical material, by Polypropylence Sheet and envelope
Filling mouth is obturaged by chewing gum, infiltrates 48 hours, impregnates complete, at the beginning of receiving as every kilogram of medical material per minute 3～5mL
Filter liquid, due-in must put into amount of alcohol 60-70% time；Put into the ethanol of 6 times amount 90% of medical material amount successively,
Add in four times, each 1.5 times, receive by every kilogram of medical material per minute 3～5mL and filter liquid, due-in must put into second
Alcohol total amount 80% time by valve wide open, put clean, reclaim ethanol with spherical recovered under reduced pressure concentration tank and be concentrated into 60
DEG C relative density is the extractum of 1.14～1.16, filters with 200 mesh filter screens while hot, receives cream, to obtain final product.
Embodiment 2: the preparation of emplastrum
Prescription: drug extract 4g, SIS-81814g, SBS-8117g, C5 are hydrogenated with 30g, naphthenic rubber
Oil 8g, far-infrared powder 0.88g, magnetic powder 7.5g, antioxidant YD1680.67g, antioxidant YD10100.33g,
Potassium sorbate 0.1g, penetrating agent 5g.
Penetrating agent prescription: Borneolum Syntheticum 6 parts, Mentholum 13 parts, natural camphor 6 parts, methyl salicylate 4 parts,
Azone 15 parts is mixed with and forms.
Preparation technology: take Borneolum Syntheticum, Mentholum, natural camphor, methyl salicylate and azone, mixing, standby；
Separately be hydrogenated with by C5, heated and stirred 2 hours in reactor put into by naphthenic rubber oil, addition SIS-818,
SBS-811 stirs 5 hours, and period temperature all controls at 130-140 DEG C, adds antioxidant YD168, antioxygen
Agent YD1010, far-infrared powder, magnetic powder, stir 2 hours, sequentially add potassium sorbate, drug extract,
Stir 50 minutes, add penetrating agent, stir 10 minutes, coating, section, to obtain final product.
Claims (4)
1. a lumbago plaster, it is characterized in that: calculate according to composition by weight, it is first made drug extract by Radix Et Rhizoma Rhei 160 parts, Rhizoma Zingiberis 80 parts, Rhizoma Kaempferiae 56 parts, the Radix Aucklandiae 20 parts, Cortex Periplocae 20 parts, Radix Angelicae Pubescentis 32 parts, 20 parts of Lignum Santali Albi, the Radix Angelicae Dahuricae 56 parts, Radix Cynanchi Paniculati 56 parts, Rhizoma Chuanxiong 20 parts, Flos Caryophylli 20 parts, Caulis et Radix Periplocae Forrestii 64 parts, Radix Dipsaci 32 parts, Radix Cyathulae 32 parts, then is prepared from adjuvant.
2. lumbago plaster as claimed in claim 1, it is characterised in that: described lumbago plaster is external patch unguentum；Carrier material used by described lumbago plaster is non-woven fabrics or release paper.
3. the preparation method of lumbago plaster described in preparation claim 1, it is characterized in that: described drug extract is prepared: take the medical material of recipe quantity, it is ground into coarse powder, adding percolate pot, add the 3-5 times amount 80%-95% ethanol of medical material amount, Jiang Guankou obturages, infiltrate 24-72 hour, impregnate complete, receive liquid of just filtering, due-in must put into amount of alcohol 60-70% time；Put into the ethanol of 4-8 times amount 80%-95% of medical material amount, point 3-5 input, receive liquid of filtering, due-in must put into ethanol total amount 70%-85% time by valve wide open, put clean, when reclaiming ethanol and be concentrated into 60 DEG C, relative density is the extractum of 1.14-1.16, filter while hot, receive cream, to obtain final product.
4. the preparation method of lumbago plaster as claimed in claim 3, it is characterized in that: described drug extract is prepared: take the medical material of recipe quantity, it is crushed to the coarse powder of 40 mesh, place backing net, press leaf, powder, the order of stem is sequentially added into percolate pot, and consolidate with wooden stick, by 4 times amount 90% ethanol sprinkles of medical material amount on the medical material of percolate pot, 30 mesh stainless (steel) wires are placed on uniform weighting material on medical material, with Polypropylence Sheet and sealing compound, filling mouth is obturaged, infiltrate 48 hours, impregnate complete, liquid of just filtering is received by every kilogram of medical material per minute 3～5mL, due-in must put into amount of alcohol 60-70% time；Put into the ethanol of 6 times amount 90% of medical material amount successively, add in four times, each 1.5 times, receive by every kilogram of medical material per minute 3～5mL and filter liquid, due-in must put into ethanol total amount 80% time by valve wide open, put clean, reclaim ethanol with spherical recovered under reduced pressure concentration tank and be concentrated into the extractum that 60 DEG C of relative densities are 1.14～1.16, filter with 200 mesh filter screens while hot, receive cream, to obtain final product.
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| CN1723935A (en) * | 2005-07-13 | 2006-01-25 | 河南羚锐制药股份有限公司 | Paste for removing obstruction in channels to relieve pain for treating osteoarthritis, and its prepn. method |
| CN1994430A (en) * | 2007-01-09 | 2007-07-11 | 北京市门头沟区中医医院 | Externally applied ointment for activating blood circulation and unblocking obstruction |
| CN102188673A (en) * | 2010-03-17 | 2011-09-21 | 赵贵凤 | Plaster for promoting muscles and bones, and preparation and application thereof |
| CN102552816A (en) * | 2012-02-15 | 2012-07-11 | 范云贤 | Plaster for treating pain and preparation method thereof |
| CN102755537A (en) * | 2012-06-28 | 2012-10-31 | 李伟 | External Chinese patent medicine for treating lumbocrural pains and application of external Chinese patent medicine |
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2014
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723935A (en) * | 2005-07-13 | 2006-01-25 | 河南羚锐制药股份有限公司 | Paste for removing obstruction in channels to relieve pain for treating osteoarthritis, and its prepn. method |
| CN1994430A (en) * | 2007-01-09 | 2007-07-11 | 北京市门头沟区中医医院 | Externally applied ointment for activating blood circulation and unblocking obstruction |
| CN102188673A (en) * | 2010-03-17 | 2011-09-21 | 赵贵凤 | Plaster for promoting muscles and bones, and preparation and application thereof |
| CN102552816A (en) * | 2012-02-15 | 2012-07-11 | 范云贤 | Plaster for treating pain and preparation method thereof |
| CN102755537A (en) * | 2012-06-28 | 2012-10-31 | 李伟 | External Chinese patent medicine for treating lumbocrural pains and application of external Chinese patent medicine |
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Address after: 550700 Changtian village, Mengjiang street, Huishui County, Qiannan Buyei and Miao Autonomous Prefecture, Guizhou Province (Longquan area, Huishui Economic Development Zone) Patentee after: GUIZHOU CONTRIVER MEDICAL INSTRUMENT CO.,LTD. Address before: 550033 Cai Chong, Shiban Town, Huaxi District, Guiyang City, Guizhou Province Patentee before: GUIZHOU CONTRIVER MEDICAL INSTRUMENT CO.,LTD. |