CN103735868A - Postoperative medicine package for anorectal diseases and preparation method of postoperative medicine package - Google Patents

Abstract

The invention discloses a postoperative medicine package for anorectal diseases and a preparation method of the postoperative medicine package. The invention is characterized in that the preparation method comprises the steps as follows: (1) extracting essential oil from leaves of Ficus vixen Ait. [F.wightana(Miq.)] Benth, seeds of Benincasahispida (Thumb.) Cogn, dry Sarcandra glabra (Thunb.) Nakai, seeds of Celosia argentea L. and coarse powder of root of Platydodon grandiflorum (Jacq.) A. DC. respectively by a vapor distillation method, collecting and mixing the essential oils for use, and keeping herb residues for use; (2) mixing Nostoc commune Vauch, Serissa serissoides (DC.) Druce or Serissa japonica (Thunb.) Thunb., Dendrobium, dry root of Peucedanum prearuptorum Dunn or dry root of Peucedanum decursivum Maxim., fructus mume,Humulus lupulus L., pawpaw and the herb residues obtained in step 1, adding water tenfold, adding water for boiling for 1 hour twice, mixing decoctions, and letting the decoctions stand; than adding ethyl alcohol into the decoctions as much as 3 to 4 times of the decoctions, letting the decoctions stand for 15 minutes, centrifuging the decoctions for 20 minutes at the speed of 3,000 rpm/min, taking clear liquid, and performing concentration and spray drying in sequence to obtain coarse material; (3) spraying the essential oils obtained in step 1 into the coarse material obtained in step 3, smashing the coarse material, screening the coarse material with a 100-mesh screen, and obtaining the postoperative medicine package through sub-packaging. Clinical experiments prove that the postoperative medicine package has the characteristics of good curing effect and higher safety in reliving postoperative pain, and is worth of being applied and popularized clinically.

Description

A kind of anal and intestinal disease is postoperative with medicated bag and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to the postoperative medicated bag and preparation method thereof of using of a kind of anal and intestinal disease.

Background technology

Recent study shows, anal and intestinal disease postoperative pain except with operation wound mutually outside the Pass, also with " postoperative pain hypersensitive state " height correlation.This kind of state factor that starts is various, and by local MDA receptor high expressed, nitric oxide and nitricoxide synthase hypersusceptibility etc. affects the threshold of pain.The so-called threshold of pain (pain threshold) refers to the minimum stimulation intensity that causes the human body aesthesia pain sensation.

" postoperative pain hypersensitive state " is irrelevant with damaging pain, the former is threshold of pain reduction in particular cases, latter mostly is the optimum reaction that the nociceptor (nociceptor) that is distributed widely in skin, muscle, joint and internal organs produces multiple noxious stimulation of different nature (chemical, mechanical, scorching hot etc.), and the impulsion of nociceptor activates central nervous system and causes pain sensation induction.So this kind of situation used analgesic after surgery, tends to cover the state of an illness, and is unfavorable for local recovery.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides the anal and intestinal disease that a kind of curative effect is affirmed and side effect is little postoperative with medicated bag and preparation method thereof.

The technical scheme that the present invention solves its technical problem is: a kind of medicine of preventing and treating anal and intestinal disease postoperative pain, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Folium fici wightianae (Ficus wightiana Wall)s, 6 ~ 12 parts of Herba Sarcandraes, 3 ~ 10 parts of Herba Dendrobiis, 6 ~ 12 parts of Nostoc, 3 ~ 10 parts of Radix Platycodoniss, 6 ~ 12 parts of Radix Peucedanis, 6 ~ 12 parts of Semen Benincasaes, 6 ~ 12 parts of Flos lupuli (Flos Humuli Lupuli)s, 6 ~ 12 parts of Fructus Mumes, 1 ~ 5 part of Semen Celosiae, 3 ~ 10 parts of Fructus Chaenomeliss, 10 ~ 25 parts of Radix Serissae.

Chinese medicine of the present invention can be prepared from by following method:

(1) by Folium fici wightianae (Ficus wightiana Wall), Semen Benincasae, Herba Sarcandrae, Semen Celosiae, Radix Platycodonis coarse powder respectively with extraction by steam distillation volatile oil, and mixing for standby use after collecting, medicinal residues are continued to employ;

(2) Nostoc, Radix Serissae, Herba Dendrobii, Radix Peucedani, Fructus Mume, Flos lupuli (Flos Humuli Lupuli), Fructus Chaenomelis, and in step 1, gained medicinal residues mix and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get clear liquid, concentrated after spraying dry, draw just material;

(3) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, pulverized 100 mesh sieves, subpackage forms.

Wherein said: Folium fici wightianae (Ficus wightiana Wall) is moraceae plants shaft of a writing brush banyan Ficus virens Ait .[F.wightana (Miq.)] leaf of Benth..Sweet in the mouth; Micro-hardship; Property is put down.Merit can heat-clearing and toxic substances removing; Removing damp to relieve itching.

Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, pungent, flat.GUIXIN, Liver Channel.Merit can clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.

Herba Dendrobii is orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., Herba Dendrobii oculati Dendrobium fimbriatum Hook. var. oculatum Hook., the fresh or dry stem of HERBA DENDROBII Dendrobium chrysanthum Wall., Herba Dendrobii Dendrobium candidum Wall. ex Lindl. or Dendrobium nobile Dendrobium nobile Lindl..Nature and flavor are sweet, are slightly cold.Return stomach, kidney channel.Merit can reinforcing stomach reg fluid, nourishing YIN and clearing away heat.

Nostoc is algae Cyanophyceae nostocaceae nostoc nostoc Nostoc commune Vauch..Nature and flavor are light, cold.Return liver, heart channel.Merit can heat clearing away, convergence, QI invigorating, improving eyesight.

Radix Platycodonis is Campanulaceae Radix Platycodonis Platycodon grandiflorum(Jacq.) dry root of A.DC..Nature and flavor are bitter, pungent, flat.Return lung meridian.Merit can lung qi dispersing, and sore-throat relieving, eliminates the phlegm, evacuation of pus.

Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum Maxim..Nature and flavor are bitter, pungent, are slightly cold.Return lung meridian.The merit wind heat clearing away of can faling apart, lowering the adverse-rising QI to resolve phlegm.

Semen Benincasae is Cucurbitaceae herbaceous plant Fructus Benincasae Benincasahispida(Thumb.) seed of Cogn..Nature and flavor are sweet, cold.Return spleen, stomach, large intestine, small intestine meridian.Function lung heat clearing, reduce phlegm, evacuation of pus.

Flos lupuli (Flos Humuli Lupuli) is the green fruit ear of immaturity of Moraceae humulus plants Flos lupuli (Flos Humuli Lupuli) Humulus lupulus L..Bitter in the mouth; Slightly cool in nature.Return liver; Stomach warp.Merit can invigorating the stomach and promoting digestion; Inducing diuresis to remove edema; Anti-consumptive disease antiinflammatory.

Fructus Mume is the dry almost ripe fruit of rose department plant plum.Sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Merit can be astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.

Semen Celosiae is the dry mature seed of amaranthaceous plant Herba Celosiae argenteae Celosia argentea L..Nature and flavor are bitter, are slightly cold.Return Liver Channel.Merit can liver heat removing, improving eyesight, nebula removing.

Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.

Radix Serissae is the herb strain of dicotyledon medicine Maguireothamnus speciosus Radix Serissae Serissa serissoides (DC.) Druce or Serissa foetida Serissa japonica (Thunb.) Thunb..Nature and flavor toil; Cool; Nontoxic.Return liver; Spleen channel.Merit can be dispeled the wind; Dampness removing; Heat clearing away; Removing toxic substances.

Composition principle: anal and intestinal disease postoperative " postoperative pain hypersensitive state ", with nmda receptor high expressed, nitric oxide is relevant with nitricoxide synthase.This kind of hypersensitive state and damaging pain are irrelevant, the former is threshold of pain reduction in particular cases, latter mostly is the optimum reaction that the nociceptor (nociceptor) that is distributed widely in skin, muscle, joint and internal organs produces multiple noxious stimulation of different nature (chemical, mechanical, scorching hot etc.), and the impulsion of nociceptor activates central nervous system and causes pain sensation induction.So this kind of situation used analgesic after surgery, tends to cover the state of an illness, and is unfavorable for local recovery.Inventor's clinical research finds, anal and intestinal disease postoperative " postoperative pain hypersensitive state " is relevant with the pathogenic wind toxic phlegm-fire among meridians, and the pathogenic wind toxic phlegm-fire channels of burning, causes pain hypersensitive state.

Compared with prior art, the present invention has following characteristics:

1, prescription is unique: in side, get Folium fici wightianae (Ficus wightiana Wall), Herba Sarcandrae is monarch, described Folium fici wightianae (Ficus wightiana Wall) coordinates with Herba Sarcandrae, for the pathogenic wind toxic phlegm-fire among the postoperative meridians of anal and intestinal disease; The constriction experiment of rat nerve root confirms: the water extraction liquid of 10mg/kg Folium fici wightianae (Ficus wightiana Wall) and Herba Sarcandrae has can reduce postoperative nmda receptor expression;

2, anus is anus outlet, and body fluid balance is most important for anus, for dry Tianjin wound of preventing fires, therefore get the heat clearing away of Herba Dendrobii Yin-nourishing and body fluid promoting, Nostoc heat clearing away QI invigorating;

3, in side, get Fructus Chaenomelis relaxing muscles and tendons, Flos lupuli (Flos Humuli Lupuli) emergency, Radix Serissae removing toxic substances, alleviates this postoperative hypersensitive state from meridians angle, and the spasm that Flos lupuli (Flos Humuli Lupuli) extract can antagonism acetylcholine causes, has smooth muscle muscle relaxation effect;

3, get Fructus Mume simply and hold back puckery using corrigent, prevent postoperative pungently and wander away, and Fructus Mume convergence and the property of medicine is steady, can not cause that local venation is not all right and impact recovers;

4, get the expectorant that Radix Platycodonis, Radix Peucedani, Semen Benincasae remove meridians;

5, in side, do not take analgesia, blood circulation promoting medicine, its reason is to remove phlegm-fire pathogenic wind toxic, and natural pain relief, as being unfavorable for local recovery with analgesic again;

6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: 20 parts of Folium fici wightianae (Ficus wightiana Wall)s, 10 parts of Herba Sarcandraes, 6 parts of Herba Dendrobiis, 10 parts of Nostoc, 6 parts of Radix Platycodoniss, 10 parts of Radix Peucedanis, 10 parts of Semen Benincasaes, 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 10 parts of Fructus Mumes, 2 parts of Semen Celosiae, 6 parts of Fructus Chaenomeliss, 20 parts of Radix Serissae.

The preparation method of embodiment 1 is: Folium fici wightianae (Ficus wightiana Wall), Herba Sarcandrae, Herba Dendrobii, Nostoc, Radix Platycodonis, Radix Peucedani, Semen Benincasae, Flos lupuli (Flos Humuli Lupuli), Fructus Mume, Semen Celosiae, Fructus Chaenomelis, Radix Serissae mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts and sooner or later uses.

Embodiment 2, crude drug weight proportion: 10 parts of Folium fici wightianae (Ficus wightiana Wall)s, 6 parts of Herba Sarcandraes, 3 parts of Herba Dendrobiis, 6 parts of Nostoc, 3 parts of Radix Platycodoniss, 6 parts of Radix Peucedanis, 6 parts of Semen Benincasaes, 6 parts of Flos lupuli (Flos Humuli Lupuli)s, 6 parts of Fructus Mumes, 1 part of Semen Celosiae, 3 parts of Fructus Chaenomeliss, 10 parts of Radix Serissae.

Embodiment 3, crude drug weight proportion: 20 parts of Folium fici wightianae (Ficus wightiana Wall)s, 10 parts of Herba Sarcandraes, 6 parts of Herba Dendrobiis, 10 parts of Nostoc, 6 parts of Radix Platycodoniss, 10 parts of Radix Peucedanis, 10 parts of Semen Benincasaes, 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 10 parts of Fructus Mumes, 2 parts of Semen Celosiae, 6 parts of Fructus Chaenomeliss, 20 parts of Radix Serissae.

Embodiment 4, crude drug weight proportion: 30 parts of Folium fici wightianae (Ficus wightiana Wall)s, 12 parts of Herba Sarcandraes, 10 parts of Herba Dendrobiis, 12 parts of Nostoc, 10 parts of Radix Platycodoniss, 12 parts of Radix Peucedanis, 12 parts of Semen Benincasaes, 12 parts of Flos lupuli (Flos Humuli Lupuli)s, 12 parts of Fructus Mumes, 5 parts of Semen Celosiae, 10 parts of Fructus Chaenomeliss, 25 parts of Radix Serissae.

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) by Folium fici wightianae (Ficus wightiana Wall), Semen Benincasae, Herba Sarcandrae, Semen Celosiae, Radix Platycodonis coarse powder respectively with extraction by steam distillation volatile oil, and mixing for standby use after collecting, medicinal residues are continued to employ;

(2) Nostoc, Radix Serissae, Herba Dendrobii, Radix Peucedani, Fructus Mume, Flos lupuli (Flos Humuli Lupuli), Fructus Chaenomelis, and in step 1, gained medicinal residues mix and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get clear liquid, concentrated after spraying dry, draw just material;

(3) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, pulverized 100 mesh sieves, subpackage forms.

Dividing the medicated bag outward appearance installing is elongated gauze bag.

Effective combination of said medicine, coordinates mutually, effectively reach the object of alleviating postoperative pain, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.

1 object and method.

1.1 objects: in June, 2011 ~ 2013 anal-surgery 120 examples in year October, male 84 examples, female's 36 examples; 18～64 years old age, average 28.5 years old.Hemorrhoid 56 examples wherein, concurrent hemorrhoid 39 examples of anal fissure, anal fistula 25 examples.Modus operandi has mixed hemorrhoid external hemorrhoid to peel off ligation of internal hemorrhoid, external hemorrhoidectomy, and anal fissure excision, internal sphincter side are cut art, anal fistulectomy, anal fistula Lower resection, high-order hanging wire art etc.By patient's date of surgery, be divided at random 3 groups, every group of 40 people.Learn and process by statistics, on age, sex, sick kind, Surgical Operation, relatively, difference not statistically significant (P>0.05), has comparability.

1.2 method.

1.2.1 Therapeutic Method: the postoperative conventional anus of matched group is filled normal saline gauze (outer wrapping monolayer oil yarn), soak group infiltrates gauze (outer wrapping monolayer oil yarn) with gained decoction in the embodiment of the present invention 1 and fills, medicated bag group is filled with gained medicated bag in the embodiment of the present invention 3 (outer wrapping monolayer oil yarn), changes dressings and is 1 time on the 1st.

1.2.2 pain intensity: by patient's judgement, 0～10 digital pain intensity staging (NPIS), record 0～2 is without pain, and 3～5 is mild pain, and 6～7 is moderate pain, and 8～10 is severe pain.

1.2.3 pain Visual analogue scale (VAS) is scored: have doctor's evaluation of scoring.

1.2.4 safety monitoring index before patient takes medicine in detail inquiry have or not dizzy, nauseating, vomiting, nervous, uncomfortable in chest, breathe hard, drowsiness, erythra, the symptom such as weak all over the body.Go forward side by side promoting the circulation of blood pressure, pulse, breathing and pupil examination, 7d detects liver function, kidney merit, routine blood test and routine urinalysis before taking medicine and after medication simultaneously.

1.2.5 observe after operation because pain is asked for analgesics situation.

1.2.6 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ ²check.

2 results.

Three groups of pain intensity comparisons (not using analgesic in 6 hours) during 2.1 postoperative 48h: matched group 5.20 ± 0.85, soak group 3.37 ± 1.09, medicated bag group 3.20 ± 1.03.Three groups of comparisons, soak group, medicated bag group pain intensity are starkly lower than matched group (P<0.05).

During 2.2 postoperative 48h, three groups of pain vision classes are made a gesture of measuring comparison (not using analgesic in 6 hours): matched group 7.60 ± 1.47, soak group 3.84 ± 1.75, medicated bag group 3.09 ± 1.41.Three groups of comparisons, soak group, medicated bag group pain situation are obviously better than matched group (P<0.05).

After 2.3 postoperative 3d, still demand wants analgesic (somedon sheet) to be respectively by lenitive case load: matched group 15 examples, soak group 7 examples, medicated bag group 5 examples.Three groups of comparisons, soak group, medicated bag group analgesics are used and are starkly lower than matched group (P<0.05).

2.4 3 groups of adverse reactions of patients incidence rates comparison: three groups obvious adverse reaction does not all occur.

3. conclusion.

This result of study shows, use soak group of the present invention and medicated bag group postoperative pain situation to be obviously better than matched group, can effectively reduce the use of analgesic, and without obvious adverse reaction, illustrate that pharmaceutical composition prepared by the inventive method has that untoward reaction is light, the higher advantage of safety aspect postoperative pain alleviating.

Claims (1)

1. an anal and intestinal disease is postoperative with medicated bag and preparation method thereof, it is characterized in that: by following raw materials according, be prepared from: Folium fici wightianae (Ficus wightiana Wall), Herba Sarcandrae, Herba Dendrobii, Nostoc, Radix Platycodonis, Radix Peucedani, Semen Benincasae, Flos lupuli (Flos Humuli Lupuli), Fructus Mume, Semen Celosiae, Fructus Chaenomelis, Radix Serissae, be comprised of following steps:

(1) by Folium fici wightianae (Ficus wightiana Wall), Semen Benincasae, Herba Sarcandrae, Semen Celosiae, Radix Platycodonis coarse powder respectively with extraction by steam distillation volatile oil, and mixing for standby use after collecting, medicinal residues are continued to employ;

(2) Nostoc, Radix Serissae, Herba Dendrobii, Radix Peucedani, Fructus Mume, Flos lupuli (Flos Humuli Lupuli), Fructus Chaenomelis, and in step 1, gained medicinal residues mix and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get clear liquid, concentrated after spraying dry, draw just material;

(3) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, pulverized 100 mesh sieves, subpackage forms.