CN103735458B - A kind of skin antiallergic maintenance compositions - Google Patents
A kind of skin antiallergic maintenance compositions Download PDFInfo
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- CN103735458B CN103735458B CN201310733808.6A CN201310733808A CN103735458B CN 103735458 B CN103735458 B CN 103735458B CN 201310733808 A CN201310733808 A CN 201310733808A CN 103735458 B CN103735458 B CN 103735458B
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Abstract
The invention discloses a kind of novel skin antiallergic maintenance compositions, by weight percentage, it comprises: wetting agent 5% ~ 12%, thickening agent 0.1% ~ 3.0%, skin-rehabilitating agent 1% ~ 4%, preservative 0.1% ~ 1.5%, water surplus.The invention also discloses the preparation method of a kind of skin repair agent.Skin repair compositions of the present invention can be made into cream and water preparation, is applied directly to affected part, nontoxic to human body skin.Skin repair composite parts therein has the effects such as the strongest heat-clearing and toxic substances removing, antiallergic reparation, antiinflammatory convergence；Other are assisted a ruler in governing a country addO-on therapy and all select and skin can be made tender, smooth, moist and non-stimulated wetting agent gentle to skin, preservative, thickening agent etc., easy to use, reach moisturizing, anti-inflammatory anti-itch, the purpose of reparation damaged skin, be suitable for the phenomenons such as skin allergy that sensitive skin and cosmetics improper use cause, pruritus, desquamation, redness, red blood streak.
Description
Technical field
The present invention relates to a kind of skin antiallergic remediation composition, belong to cosmetic formulations technical field.
Background technology
Along with the progress of modern science and technology, the raising of people's living standard, people are for healthy and beautiful appearance
Pursue increasingly stronger, municipal pollution, industrial waste gas, ultraviolet irradiates, the use of defective cosmetics with
And the abuse of various U.S.s treatment instrument endangers our skin, the most day by day according to statistics display in 2004, contact
Dermatitis is most commonly seen in six big class cosmetic dermatosises, and its sickness rate accounts for cosmetic dermatosis total incidence
82.6%.Allergy has seemed pursuing bad dream like the shadow following the person on healthy beautiful road into people.Treatment sensitive or
The diseases such as the multiple erythema of allergic skin, pimple, desquamation, pruritus, need to use sugar skin parahormone；If it is long
Phase Reusability hormone, it may appear that atrophoderma, telangiectasis, purpura, acne pigment anomaly, light
The symptoms such as allergy, the women liked to be beautiful to the modern times brings endless worry, and hormone therapy is easily generated dependency.
How to find the method safely and effectively alleviating allergic symptom, the problem becoming people's growing interest.In recent years
Cosmetic industry progressively towards advocating green, the direction of back to nature is developed.But most plants antiallergic
Additive curative effect is the most not satisfactory, the exploitation natural antiallergic active substance containing unique effects, and is added to
In cosmetics, develop natural safe and effective antiallergic product, become cosmetic industry develop most active theme it
One.
The present invention is i.e. based on differential diagnosis in tcm principle, for sensitive or the multiple dermatitis of damaged skin, imposes
Antiallergic anti-inflammatory medicine combined extracts, is aided with other component raw material simultaneously, makes contained effective ingredient tool in formula
There are heat-clearing and toxic substances removing, antiallergic reparation, convergence antiinflammatory, increase the effect such as skin elasticity and gloss.This skin antiallergic
Repair combination and can be done directly on skin damage position, compared to the oral or nontoxic secondary work of injectivity antiallergic medicine
With, effective, easy to use, the congestion and swelling pain caused due to skin allergy can be alleviated rapidly, solve
The vast women that likes to be beautiful during cosmetics use, puzzlement that phenomena of cutaneous irritation frequently produces, and adopting
Bigger skin lesion problem patient caused by hormone therapy allergic skin inflammation.Both sensitivity it had been suitable for
Property skin, for the alleviation of allergic symptom and prevention, is suitable for again the allergy caused due to cosmetics improper use
Symptom.
Summary of the invention
It is an object of the invention to provide one directly act on skin sensitivity position, pure natural extract, nontoxic
Side effect, effective simple to operate；Compact while alleviating allergic symptom skin, strengthens skin opposing
Power；To solve cosmetics improper use light, the moderate allergic symptom that cause, meet people for skin care,
Gentle antiallergic, safe and effective three kinds of demands, it is to avoid use the injury that hormone antiallergic brings to skin.
The present invention is to realize above-mentioned purpose by following technical solution:
A kind of skin antiallergic maintenance compositions, it is characterised in that: it is by the raw material system of following weight percents
Become:
Preferably, it also comprises the Defensil that percentage by weight is 0.1%-2%.
Wherein, Defensil is the plant antisensitizer that RAHN COSMETICS company produces.
Preferably, described wetting agent is: glycerol, hyaluronate sodium, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch water
Solve one or more in thing (MG60), propylene glycol, butanediol, trimethyl glycine (glycine betaine).
Preferably, the addition of described wetting agent is: glycerol 4%～8%, hyaluronate sodium 0.03%～0.5%,
Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate (MG60) 0.1%～0.5%, propylene glycol 4%～8%,
Butanediol 4%～8%, trimethyl glycine 1%～7%.
Preferably, described wetting agent is: glycerol 4%～8%, hyaluronate sodium 0.03%～0.5%, Fructus Hordei Germinatus oligose
Glucoside/hydrogenated starch hydrolysate (MG60) 0.1%～0.5%.
Preferably, described thickening agent be carbomer, acrylate-13 (with) polyisobutylene (with) poly-mountain
Pears alcohol ester-20 (SEPIPLUS 400), 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers
(SEPINOV EMT10), polyacrylamide/laureth-7/C13-14 isoparaffin (GEL305),
Sodium polyacrylate (with) caprylic/capric triglyceride (with) Dormant oils (with) three (PPG-3 Semen Myristicae alcohol ethers),
Citrate (with) the smooth laurate of Pyrusussuriensis (with) one in trideceth-6 (RMA-IS) or
Several.
Preferably, described skin-rehabilitating agent is that Herba Plantaginis, Herba Silybi mariani, the alcohol extraction thing of Radix Sophorae Flavescentis and red wine are many
The mixture of phenol.It is highly preferred that described skin-rehabilitating agent be Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis equal portions be blended
Alcohol extraction thing and the grape procyanidins of equal portions.
Preferably, primary efficacy raw material is Defensil and skin-rehabilitating agent combination.
Preferably, the preparation method of described antiallergic renovation agent is: take raw material of Chinese medicine Herba Plantaginis, Herba Silybi mariani,
Radix Sophorae Flavescentis, takes identical deal and cleans, dry, and pulverizes and extracts with butanediol after being blended, red with equal portions after filtration
Wine polyphenol mixes, and adds other raw materials above-mentioned and deionized water, is prepared as cream, breast according to manufacturing process
Liquid, elite, water are directly smeared.It is further preferred that described butanediol extracting method is: use 1,3 butylene glycol
50-70 DEG C of constant temperature stirs 2-4 hour, stands 7-9 hour, takes supernatant liquid filtering.
The preparation method of the present invention a kind of skin antiallergic maintenance compositions is: be grouped according to thermostability by raw material,
Heating for dissolving, is cooled to 38 DEG C or the thermo-labile active component of following addition, stirs and i.e. can get the present invention
Product.
Prescription dissects:
The present invention is based on differential diagnosis in tcm principle, imposes antiallergic disappear for sensitive or the multiple dermatitis of damaged skin
Scorching Chinese medicine composition extract, is aided with other component raw material simultaneously, makes preparation have a heat-clearing and toxic substances removing, anti-inflammation and sterilization,
Convergence is repaired, is strengthened skin resistance, and elasticity and the gloss etc. that improve skin act on.Wherein Radix Sophorae Flavescentis heat clearing away is dry
Wet, there is the effect of good bactericidal antiphlogistic.Herba Plantaginis, is China's Chinese medicine, has clearing away heat and promoting diuresis treating stranguria,
Eliminate the phlegm, removing heat from blood, effect of removing toxic substances.Herba Silybi mariani seed contains flavonoid drugs, and nature and flavor are bitter, cool, has clear
Thermal detoxification, protect the liver, the effect such as function of gallbladder promoting.Grape procyanidins, also known as grape seed procyanidine, is a kind of plant polyphenol kind
Active substance, numerous studies show, grape procyanidins has antioxidation, removes free radical, antimicrobial, radioprotective
Etc. biologic activity, antiviral, anti-inflammatory etc. act on.Radix Sophorae Flavescentis is cold in nature, has heat clearing and damp drying, Sage Extract to divide
Secrete, dredge and restrain pore, remove the effects such as skin endotoxin contamination.Abundant herbal nutrition, promotes to be subject to
Damage growth and the reparation of nervus vasculairs cell, recover subcutaneous capillary cell viability, play beauty and skin care
Effect.
The wetting agent that present invention preferably employs is glycerol, propylene glycol, butanediol, Fructus Hordei Germinatus oligose glucoside/hydrogenation
Glucidtemns (MG60), glycine betaine and hyaluronate sodium.
Glycerol that is to say glycerol (Glycerin).It is a kind of colourless, odorless, pleasantly sweet, clear
Dense fluids, be internationally recognized high-performance wetting agent, its safety obtains the whole world and generally admits, extensively
Apply to the industries such as medicine, food, cosmetics.Glycerol has the strongest hygroscopicity, can be in skin surface shape
Become thin film, air can be completely cut off and prevent moisture from evaporating, making skin not frost bitten, not by dust etc.
Infringement, so that skin keeps soft and high resilience.
1,3 butylene glycol is a kind of no color or smell thick liquid, has good hygroscopicity.To skin and eyes without
Stimulation, to oral mucosa nonirritant, the most harmless, it is usually used in skin care item, plays moisture-keeping function.1,3-
Butanediol also has antibacterial action, its minimum inhibitory concentration to each quasi-microorganism: streptococcus pneumoniae I type, hammer
The mass fraction of bacterium c-type and A type is 5%, and staphylococcic mass fraction is 15%.
MG60 (Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate), is a carbon water born by starch derivatives
Compound syrup wetting agent, it and glycerol have the assosting effect of uniqueness to the moisture equilibrium at dry side optimizing skin, sweet
Oil can improve dry skin, and MG60 can keep the pliability of skin, and in addition, it can delay
Solve stimulation and pruritus that sensitive skin produces owing to contacting potent surfactant, be particularly suited for aiming at
In the product of sensitive skin formula.
Glycine betaine is natural molecule present in nature, and it is present in shellfish and plant, is
The product of the Radix Betae course of processing, in molasses, content reaches 8%.Due to trimethyl glycine contained in glycine betaine
There is the polar end molecule combining the most by force hydrogen atom, so, it can be combined strongly with the molecule of water and similar water,
So that it has the physicochemical property of uniqueness, in skin care item, application makes skinfeel smooth as silk is thick.Because it has
There is pH cushioning effect, therefore in cosmetics, the high moisture-keeping function of trimethyl glycine and the thorn of reduction skin
Sharp property is very effective.
Hyaluronic acid is the important component generally existed in intercellular matrix, and it is filled in the cell of various tissue
Between space (such as cells such as skin, cartilage, muscle and muscle).Hyaluronan molecule most important biology
The function of aspect is the ability keeping moisture in intercellular substance, and it keeps other any skies of energy force rate of moisture
So or synthetic polymer is strong, the pure hyaluronic acid aqueous solution of 2% can firmly keep mass fraction to be 98%
Moisture.Viscoelastic thin film can be formed when hyaluronic acid solution is applied in skin surface, these thin film as
The hyaluronic acid that skin connects in the intercellular matrix of tissue equally has water-retaining property, and without vestiges or greasy feeling,
And have softness, smooth and lubricious skinfeel.
The thickening agent of the present invention be preferably carbomer, acrylate-13 (with) polyisobutylene (with) poly-Pyrusussuriensis
Alcohol ester-20 (SEPIPLUS 400), 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers
(SEPINOV EMT10), polyacrylamide/laureth-7/C13-14 isoparaffin (GEL305),
Sodium polyacrylate (with) caprylic/capric triglyceride (with) Dormant oils (with) three (PPG-3 Semen Myristicae alcohol ethers)
Citrate (with) the smooth laurate of Pyrusussuriensis (with) one in trideceth-6 (RMA-IS) or
Several.
There is after above-mentioned all components compatibility the collaborative effect of heat clearing away, removing toxic substances, removing heat from blood, dermatitis can be eliminated
Disease, convergence is moist, and radiant skin repairs damaged part, recovers elasticity and the gloss of skin.Can be the most scattered
Carbuncle, clean skin are hyperchromic, can nourish again protection skin, be suitable for skin allergy caused by cosmetics improper use,
The skin types such as pruritus, desquamation, redness, red blood streak.
In the raw material components that the present invention is above-mentioned, property feature and effect of the raw material of Chinese medicine of skin repair are as follows:
Herba Plantaginis, Herba Plantaginis has another name called wheel dish, is China's Chinese medicine, uses (" Chinese Pharmacopoeia " with a long history
Within 2010, version is recorded), it is treating stranguria that Herba Plantaginis has clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, effect of removing toxic substances, for heat
Drench puckery pain, edema oliguria, diarrhea due to summer heat and dampness, carbuncle sore tumefacting virus.Modern scientific research shows Herba Plantaginis effective ingredient
Mainly include apigenin, luteolin, Homoplantaginin, phenethyl alcohol glycoside, cyclenes ether mushroom, triterpene and sterol,
The various trace elements such as Ca, Mn, Zn, Fe, Cu, prove after deliberation, and Herba Plantaginis alcohol extraction thing has to be repaiied
The multiple effect such as damaged cell and antiphlogistic antibacterial.
Radix Sophorae Flavescentis, cold in nature, there is heat clearing and damp drying, effect of sterilization, Radix Sophorae Flavescentis is bathed can remove damp-heat in lower-JIAO, and
Sterilizing and itch-relieving, has good mitigation to skin pruritus, the matrine that its spy contains can Bergamot Mint Extract,
Dredge and restrain pore, remove skin endotoxin contamination, promote growth and the reparation of damaged blood vessels neurocyte,
Recover subcutaneous capillary cell viability, reappear skin and compact fine and smooth, play the effect of beauty and skin care.Additionally
Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus；Radix Sophorae Flavescentis water logging agent is to violet
Trichophyton, Trichophyton concentricunm, trichophyton, Du big belly little spore tinea bacterium difficult to understand etc. have inhibitory action.
Grape procyanidins, also known as grape seed procyanidine, is a kind of plant polyphenol kind active substance, can be dissolved in water, easily
It is dissolved in the organic solvent such as methanol, ethanol.It is widely present in Semen Vitis viniferae, Pericarpium Vitis viniferae and fruit juice, in a large number
Research shows, grape procyanidins has antioxidation, removes the biologic activity such as free radical, antimicrobial, radioprotective,
Medically having the most wide application prospect, it has anticancer, resisting hypertension, antiviral, anti-inflammatory etc. and makees
With.
The beneficial effects of the present invention is:
Skin antiallergic maintenance compositions of the present invention can be made into cream and water preparation, is applied directly to affected part, to human body
Skin is nontoxic.Skin repair composite parts therein has the strongest heat-clearing and toxic substances removing, antiallergic reparation, disappears
The effects such as scorching convergence；Other are assisted a ruler in governing a country addO-on therapy and all select skin can be made tender, smooth, moist and to skin
Gentle non-stimulated wetting agent, preservative, thickening agent etc., easy to use, reach moisturizing, disappear
Scorching antipruritic, the purpose of reparation damaged skin.Skin antiallergic maintenance compositions of the present invention be suitable for sensitive skin with
And cosmetics improper use cause skin allergy, pruritus, desquamation, redness, the phenomenon such as red blood streak.
Exemplary:
Zhuhai, Wang, female, 26 years old, owing to using skin care item to cause erubescence, swelling, pruritus, pain
Bitterly, desquamation.Use this product is erubescence, pruritus, transference cure after three days, and desquamation phenomenon alleviates, after 8 days
Desquamation symptom substantially alleviates, and fully recovers after 15 days.
Claims (7)
1. a skin antiallergic maintenance compositions, it is characterised in that: by weight percentage, it comprises:
Wherein, described skin-rehabilitating agent is the mixed of Herba Plantaginis, Herba Silybi mariani, the alcohol extraction thing of Radix Sophorae Flavescentis and grape procyanidins
Compound.
2. a skin antiallergic maintenance compositions, it is characterised in that: by weight percentage, it comprises:
Wherein, described skin-rehabilitating agent is the mixed of Herba Plantaginis, Herba Silybi mariani, the alcohol extraction thing of Radix Sophorae Flavescentis and grape procyanidins
Compound.
A kind of skin antiallergic maintenance compositions the most according to claim 1 and 2, it is characterised in that: described guarantor
Humectant is: glycerol, hyaluronate sodium, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate, propylene glycol, fourth two
One or more in alcohol, glycine betaine.
A kind of skin antiallergic maintenance compositions the most according to claim 3, it is characterised in that: described wetting agent
Addition be: glycerol 4%～8%, hyaluronate sodium 0.03%～0.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenation forms sediment
Powder hydrolysate 0.1%～0.5%, propylene glycol 4%～8%, butanediol 4%～8%, glycine betaine 1%～7%.
A kind of skin antiallergic maintenance compositions the most according to claim 1 and 2, it is characterised in that: described
Thickening agent is carbomer, acrylate-13 and polyisobutylene and polysorbate-20,2-(Acryloyloxy)ethanol/the third
Alkene acyl dimethyltaurine sodium copolymer, polyacrylamide/laureth-7/C13-14 isoparaffin, poly-third
Olefin(e) acid sodium and caprylic/capric triglyceride and Dormant oils and three (PPG-3 Semen Myristicae alcohol ether) citrate and Pyrusussuriensiss
One or more in smooth laurate and trideceth-6.
A kind of skin antiallergic maintenance compositions the most according to claim 1 and 2, it is characterised in that: described
Skin-rehabilitating agent is the grape procyanidins that Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis equal portions are blended alcohol extraction thing and equal portions.
A kind of skin antiallergic maintenance compositions the most according to claim 1 and 2, it is characterised in that: skin is repaiied
Multiple agent preparation method is as follows: Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, cleans, and dries, takes identical part
Amount is pulverized after being blended, and stirs 2-4 hour with 50-70 DEG C of constant temperature of 1,3 butylene glycol, stands 7-9 hour, take
Clear liquid filters, and mixes with the red wine polyphenols of equal portions.
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| CN112807262A (en) * | 2021-01-26 | 2021-05-18 | 广州华厦生物制药有限公司 | Plant efficient moisturizing repair cream |
| CN114344237B (en) * | 2022-01-15 | 2022-11-15 | 广州市蒂洲生物科技有限公司 | Plant composite maltotetraose moisturizing repair agent and preparation method thereof |
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