CN103721186B - A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome and preparation method thereof, relate to the field of medicinal compositions for the treatment of diabetes and climacteric syndrome.It is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng, Polyporus and Hirudo are 20 ~ 30 parts, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis, Herba Cistanches, Fructus Lycii, Carapax Trionycis, Herba Dendrobii, Fructus Crataegi, Fructus Chaenomelis, Endothelium Corneum Gigeriae Galli, Radix Polygalae, Rhizoma Alismatis, Rhizoma Atractylodis, Radix Scutellariae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Curcumae, Rhizoma Sparganii, Radix Achyranthis Bidentatae and Rhizoma Chuanxiong are 25 ~ 35 parts, and Caulis Polygoni Multiflori, Herba Taraxaci, Herba Houttuyniae, Herba Leonuri, Herba Portulacae, Fructus Rosae Laevigatae and Placenta Hominis are 35 ~ 45 parts; The Chinese medicine of above-mentioned weight proportion soaks through yellow wine and steams, and leaches Chinese medicine, obtain medicine yellow wine after cooling.The present invention has safe and reliable, has no side effect, and easily absorbs, instant effect, takes simple, can adjust the advantage of visceral peritoneum balance, reach 85%, reach 90% to the cure rate of climacteric syndrome to the cure rate of diabetes.

Description

A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome and preparation method thereof

Technical field

The present invention relates to the pharmaceutical composition for the treatment of diabetes and climacteric syndrome, especially a kind of medicine yellow wine taking Chinese medicine as raw material and make.

Background technology

Diabetes are a kind of because of a series of clinical syndromes that insulin in body is absolute or relative deficiency causes, and have very close associating with gene.The main clinical manifestation of diabetes is polydipsia, polyuria, polyphagia and weight loss (" three-many-one-little "), and blood glucose is high, in urine containing glucose (should not contain glucose in normal urine) etc.

Diabetes be only second to cardiovascular and cerebrovascular disease, cancer, acquired immune deficiency syndrome (AIDS) and rank the 4th world pop disease, very generally.World Health Organization's report of 2011 points out that the whole world has 3.46 hundred million people to suffer from diabetes.And Asia diabetes association reveals, in 2012, the total number of persons of national trouble diabetes has reached 9,240 ten thousand, and onset diabetes rate is up to 9.7%, and diabetes present situation is very severe.

At present can control diabetes well by multiple treatment means.Mainly comprise: self-monitoring of blood glucose, Diet Therapy, exercise therapy and Drug therapy.Drug therapy comprises: oral drug therapy, and as biguanides, sulfonylurea drugs etc., but it is while control blood sugar for human body, also can have side effects to gastrointestinal tract, liver, kidney etc.; Insulinize, for a long time with easily producing antibody, biological activity reduces, and dosage increases, and produces hyperinsulinemia, promotes microangiopathic generation.

Although also there is the Chinese patent medicine of some treatment diabetes, because therapeutic effect is not obvious, patient still needs to adopt western medicine.

Climacteric syndrome refers to that women is at climacteric or thereafter, fails gradually because of ovarian function or loses, thus caused by decrease in estrogen based on a series of syndromes of autonomic nervous dysfunction's dysbolismus.Climacteric is that human body moves towards old and feeble transition stage by maturation.This stage comprises: premenopause, menopause, postmenopause.Climacteric syndrome is multiple is born between 45 ~ 55 years old, generally when Menopausal transitional period menoxenia, these symptoms started occur, may persist to post menopausal 2 ~ 3 years, only a few peoples to menopause after 5 ~ 10 years symptom just can alleviate or disappear.Climacteric syndrome often has following symptom: menoxenia, old property warm flushing, sweating, serious, and kidney loses, cause lumbar and back pain, nervous, headache, irritated, insomnia, fatiguability, incoordination between the spleen and stomach, each side health declines, easy complicated with cardiovascular system, skeletal musculature, urinary system, disease of immune system, to climacteric, patient brings considerable distress.Climacteric women is due to the decline of ovarian function, estrogen level reduces, gonadotrophin secretion level increases, cause autonomic nervous dysfunction, cause various forms of mental maladjustment, these negative emotions cause a large amount of secretions of some stress hormone in body, and these hormones are all the hormones of raise blood sugar, meeting and insulin are resisted mutually, and reduce the glycometabolic regulating power of human body, this is all the cause of disease that climacteric women easily suffers from diabetes.And the women of originally diabetics, can because above-mentioned reason make the more difficult control of blood glucose after entering into the climacteric period.Climacteric progestogen and estrogenic minimizing likely cause health that some physiological change occurs, these physiological changies likely can increase the weight of diabetic complication.Such as, the effect that estrogen has prevention cardiovascular pathological changes to occur, when estrogen produces minimizing, the danger that cardiovascular pathological changes and apoplexy occur will be risen, and the probability that these pathological changes occur diabetics itself is just larger.

Male menopause symptom mainly loss of appetite, weight loss, libido suppress or lose, property reaction is slow, erection is difficult or hardness is inadequate, absent minded, emotional, tired etc.Because climacteric hormone in vivo regulatory function is disorderly, body carbohydrate tolerance reduces, and the regulating action of insulin to blood glucose weakens, and muscular labor kinetic energy reduces in addition, and thus easily blood glucose rises, even induced Diabetic.

Controversies in hormone replacement in the elderly (HormoneReplacementTherapy, HRT) be the Main Means for the treatment of climacteric syndrome at present, curative effect is better, but clinical effectiveness shows, serious side effect can be caused after patient's prolonged application controversies in hormone replacement in the elderly, comprise metrorrhagia, stimulate mammary glandular cell, endometrial hyperplasia, increase the serious adverse reaction such as breast carcinoma, onset of endometrial cancer rate.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome and preparation method thereof, have safe and reliable, have no side effect, easy absorption, instant effect, takes simple, can adjust the advantage of visceral peritoneum balance, 85% is reached to the cure rate of diabetes, 90% is reached to the cure rate of climacteric syndrome.

For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 20 ~ 30 parts, the Radix Astragali 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 25 ~ 35 parts, Radix Morindae Officinalis 25 ~ 35 parts, Herba Cistanches 25 ~ 35 parts, Fructus Lycii 25 ~ 35 parts, Carapax Trionycis 25 ~ 35 parts, Herba Dendrobii 25 ~ 35 parts, Fructus Crataegi 25 ~ 35 parts, Fructus Chaenomelis 25 ~ 35 parts, Endothelium Corneum Gigeriae Galli 25 ~ 35 parts, Radix Polygalae 25 ~ 35 parts, Caulis Polygoni Multiflori 35 ~ 45 parts, Polyporus 20 ~ 30 parts, Rhizoma Alismatis 25 ~ 35 parts, Rhizoma Atractylodis 25 ~ 35 parts, Radix Scutellariae 25 ~ 35 parts, Herba Taraxaci 35 ~ 45 parts, Herba Houttuyniae 35 ~ 45 parts, Herba Leonuri 35 ~ 45 parts, Radix Salviae Miltiorrhizae 25 ~ 35 parts, Hirudo 20 ~ 30 parts, Radix Angelicae Sinensis 25 ~ 35 parts, 25 ~ 35 parts, Radix Rehmanniae Preparata, Herba Portulacae 35 ~ 45 parts, Fructus Rosae Laevigatae 35 ~ 45 parts, Rhizoma Curcumae 25 ~ 35 parts, Rhizoma Sparganii 25 ~ 35 parts, Radix Achyranthis Bidentatae 25 ~ 35 parts, Rhizoma Chuanxiong 25 ~ 35 parts, Placenta Hominis 35 ~ 45 parts.

Preferably, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 25 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Radix Morindae Officinalis 30 parts, Herba Cistanches 30 parts, Fructus Lycii 30 parts, Carapax Trionycis 30 parts, Herba Dendrobii 30 parts, Fructus Crataegi 30 parts, Fructus Chaenomelis 30 parts, Endothelium Corneum Gigeriae Galli 30 parts, Radix Polygalae 30 parts, Caulis Polygoni Multiflori 40 parts, Polyporus 25 parts, Rhizoma Alismatis 30 parts, Rhizoma Atractylodis 30 parts, Radix Scutellariae 30 parts, Herba Taraxaci 40 parts, Herba Houttuyniae 40 parts, Herba Leonuri 40 parts, Radix Salviae Miltiorrhizae 30 parts, Hirudo 25 parts, Radix Angelicae Sinensis 30 parts, 30 parts, Radix Rehmanniae Preparata, Herba Portulacae 40 parts, Fructus Rosae Laevigatae 40 parts, Rhizoma Curcumae 30 parts, Rhizoma Sparganii 30 parts, Radix Achyranthis Bidentatae 30 parts, Rhizoma Chuanxiong 30 parts, Placenta Hominis 40 parts.

The preparation method of described medicine yellow wine is: first by the herbal medicine immersion of described weight proportion in yellow wine, described yellow wine gross weight is 3 ~ 6 times of Chinese medicine gross weight, and soak time is 1 ~ 3h, 2 ~ 3h is steamed again at 90 ~ 100 DEG C, after cooling, Chinese medicine is leached, obtain medicine yellow wine.

The side of medicine yellow wine of the present invention separates as follows:

Radix Ginseng: sweet, micro-hardship, tepor; Return spleen, lung meridian.Effect: strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, increasing intelligence of calming the nerves.

The Radix Astragali: sweet, tepor; Return spleen, lung meridian.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For the anorexia and loose stool of spleen, insufficiency of lung-QI, the metrorrhagia that the weak and deficiency of vital energy of losing heart can not take the photograph blood is had blood in stool, and defends the spontaneous perspiration that void is not solid, and the carbuncle caused by insufficiency of vital energy and blood is not burst or burst and the card such as not hold back for a long time; Have diabetics and increase insulin sensitivity and fall hypoglycemic effect; Containing the necessary trace element-selenium of human body in the Radix Astragali, selenium is the natural enemy of cancer, can prophylaxis of cancer.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm; Return spleen, stomach warp.Effect: the spleen strengthening and damp drying, strengthening superficial resistance to stop perspiration, diuretic is antiabortive.For weakness of the spleen and stomach, the anorexia and loose stool caused by dysfunction of the spleen in transportation and transformation, distension and fullness in the abdomen, the cards such as lassitude.

Radix Morindae Officinalis: pungent, sweet, tepor; Return kidney channel.Effect: reinforcing the kidney and supporting YANG, bone and muscle strengthening, wind-damp dispelling.For the sexual impotence of insufficiency of kidney-YANG, frequent micturition, infertile, menoxenia, the cards such as cold and pain in the lower abdomen.Also to wither weakness for the bone of nephrons deficiency.

Herba Cistanches: sweet, salty, warm; Return kidney, large intestine channel.Effect: the kidney invigorating rib sun, loosening bowel to relieve constipation.For the impotence and premature ejaculation of kidney yang deficiency, asthenia of essence and blood, cold womb is infertile, chills and pain of the waist and kness or the card such as muscles and bones is unable.

Fructus Lycii: sweet, flat; Return liver, kidney, lung meridian.Effect: nourishing the liver and kidney, lung moistening, improving eyesight.For the soreness of the waist and knees caused by the hepatic and renal YIN deficiency, the cards such as seminal emission.Also quench one's thirst for the deficiency of YIN, deficiency of YIN chronic cough.

Carapax Trionycis: salty, cold.Return Liver Channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.For deficiency of YIN hectic fever, the power of heat clearing away is better than Carapax et Plastrum Testudinis.

Herba Dendrobii: sweet, be slightly cold; Return stomach, kidney channel.Effect: nourishing the stomach to promote the production of body fluid, YIN nourishing heat extraction.For consumption of YIN caused by febrile disease, or dry mouth caused by stomach deficiency of the kidney yin is thirsty, and Yin and fluid deficiency deficiency-heat does not move back person.For cards such as the gastralgia caused by deficiency of stomach-Yin, retch, the few tongues of tongue light, also for cards such as damage of kidney-YIN, waist knee joint weaknesses.

Fructus Crataegi: sweet, sour, tepor; Return spleen, stomach, Liver Channel.Effect: promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.For eating accumulation, be especially applicable to the distension and fullness in the abdomen caused by meat stagnation, wrist pain such as to be had loose bowels at the card.

Fructus Chaenomelis: sour, warm; Return liver, spleen channel.Effect: help digestion stomach function regulating.For the distension and fullness in the abdomen in turbid damp resistance, diet such as not to disappear at the card.

Endothelium Corneum Gigeriae Galli: sweet, flat; Return spleen, stomach, small intestinal, urinary bladder channel.Effect: activating the spleen helps digestion, controlling nocturnal emission with astringent drugs is only lost.For dyspepsia, the card such as accumulation of food in the stomach and intes tine due to indigestion and infantile malnutrition.

Radix Polygalae: pungent, bitter, tepor; GUIXIN, lung meridian.Effect: mind calming, calm the nerves, eliminate the phlegm and have one's ideas straightened out.For irritability, palpitation with fear insomnia, confuse forgetful wait card.

Caulis Polygoni Multiflori: sweet, flat; GUIXIN, Liver Channel.Effect: tranquilizing by nourishing the heart.Be insomnia for fidgets due to deficiency, the cards such as dreaminess.

Polyporus: sweet, light, flat; Return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen.For dysuria, edema distension, beriberi, has loose bowels, stranguria with turbid discharge, is with inferior water to wet stayer.

Rhizoma Alismatis: sweet, light, cold; Return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen, expels the heat-evil.For dysuria, edema distension, dizziness due to fluid-retention, stranguria with turbid discharge leukorrhagia, has loose bowels, the cards such as oliguria with reddish urine.

Rhizoma Atractylodis: acrid, bitter, warm; Return spleen, stomach warp.Effect: diuretic dampness.For the edema phlegm retention of insufficiency of the spleen leading to overabundance of dampness, have diuretic by wet merit, and can be used for damp stop up Sheng let out profit, leukorrhagia.

Radix Scutellariae: bitter, cold; Return lung, gallbladder, stomach, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.For the damp and hot caused card such as hygropyrexia, jaundice, dysentery, pyretic stranguria, carbuncle pyogenic infections from tumour or sore.

Herba Taraxaci: bitter, sweet, cold; Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dampness removing is treating stranguria.For pyretic toxicity carbuncle and ulcer furuncle.

Herba Houttuyniae: pungent, be slightly cold; Return lung meridian.Effect: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Vomiting bloody pus is coughed and the card such as cough due to lung-heat's expectorant is thick for lung abscess.

Herba Leonuri: pungent, bitter, be slightly cold; GUIXIN, liver, urinary bladder channel.Effect: blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.For the menoxenia of blood vessels retardance, pass through smooth, lower abdominal distention pain, amenorrhea, puerperal abdonimal pain, lochiorrhea, and traumatic injury, blood stasis such as to be had a pain at the card.

Radix Salviae Miltiorrhizae: bitter, be slightly cold; GUIXIN, pericardium, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind.Be ill card for multiple blood stasis, as menoxenia, amenorrhea, puerperal abdonimal pain, trusted subordinate's pain, lump in the abdomen and limbs pain etc. are applicable with the stagnant person of the heat in blood stasis of blood especially.

Hirudo: salty, bitter, flat, slightly poisonous; Return Liver Channel.Effect: removing blood stasis.Be used for the treatment of blood stasis and stagnate the cards such as the amenorrhea, lump in the abdomen, mass in the abdomen, the blood-retention that cause are gone mad, distension in the lower abdomen pain.

Radix Angelicae Sinensis: sweet, pungent, warm; Return lung, spleen, heart channel.Effect: to invigorate blood circulation, pain relieving.For menoxenia, amenorrhea, dysmenorrhea is Fuke Tiaojing key medicine; Also have a pain for asthenia cold abdominalgia, blood stasis, traumatic injury, arthralgia pain is numb; Also for ulcer sores.

Radix Rehmanniae Preparata: sweet, tepor; Return liver, kidney channel.Effect: nourishing the blood and yin, beneficial lean marrow.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, the cards such as metrorrhagia; Also for deficiency of kidney yin hectic fever, night sweat, seminal emission sexual impotence, quench one's thirst, and blood and essence asthenia, waist soreness, the cards such as Light-headedness deafness and tinnitus.

Herba Portulacae: sour, cold; Return large intestine, Liver Channel.Effect: for pyretic stranguria, the stranguria with blood of stagnation of damp-heat, and all cards of damp-heat vaginal discharge.

Fructus Rosae Laevigatae: sour, puckery, flat.Return kidney, bladder, large intestine channel.Effect: controlling nocturnal emission with astringent drugs, reducing urination, relieving diarrhea with astringents.For the not solid caused card such as seminal emission, spermatorrhea, the enuresis, frequent micturition, leukorrhagia of suffering from a deficiency of the kidney; Also for chronic diarrhea chronic dysentery, slippage be can't help; Also for proctoptosis, uterine prolapse, the cards such as metrorrhagia.There is the merit of arresting collape syndrome by astringents, should compatibility relative medicine.

Rhizoma Curcumae: acrid, bitter, warm.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.For the amenorrhea of band of gas blood stasis, the cards such as stomachache and lump in the abdomen.

Rhizoma Sparganii: bitter, flat.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.For the invigorating the liver and kidney of band of gas blood stasis, bone and muscle strengthening, amenorrhea dysmenorrhea, stomachache, postpartum stagnation, and the card such as lump in the abdomen.

Radix Achyranthis Bidentatae: bitter, sour, flat.Return liver, kidney channel.Effect: blood circulation promoting and blood stasis dispelling, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome.For the menoxenia of stagnation of blood stasis, dysmenorrhea, amenorrhea, the card such as puerperal abdonimal pain and traumatic injury; Also for vim and vigour superinverse, burning hot upper headache caused by inflammation, dizzy, toothache, aphtha of the mouth and tongue and the card such as haematemesis, epistaxis.

Rhizoma Chuanxiong: pungent, warm.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, dysmenorrhea, amenorrhea, postpartum stagnation is suffered from abdominal pain, pain in chest and hypochondrium, numb limbs and tense tendons and traumatic injury, the cards such as sore, carbuncle and painful swelling.

Placenta Hominis: sweet, salty, warm.Return lung, liver, kidney channel.Effect: QI invigorating, mends essence, nourishes blood.For the deficient caused cards such as weak, shallow complexion of becoming thin of QI and blood; Also for deficiency of kidney-QI, essence and blood declines less caused infertile, sexual impotence, seminal emission, and the soreness of waist is dizzy, the cards such as tinnitus; Also for the dyspnea and shortness of breath of deficiency of both the lung and kidney.

The traditional Chinese medical science claims diabetes to be diabetes, its pathogenesis mainly intense heat due to deficiency of YIN, and internal organs are deficient, deficiency of YIN affecting YANG, deficiency of both YIN and YANG; Deficiency of kidney yin, kidney yang virtual loss, yang deficiency cold coagulation, blood is puckery obstructed, deficiency of vital energy internal resistance, and passages through which vital energy circulates blocks, and forms deficiency of both YIN and YANG, caused by gas YANG deficiency; With the passing of time, spleen kidney is two to be lost, organ failure, dirty decline sick all.In the rule for the treatment of, according to the pathogenesis of " deficiency of YIN is the pathogenetic essence of glycosuria; the deficiency of vital energy is the crux that diabetes do not heal; blood stasis is the key of diabetic complications; deficiency of both YIN and YANG is the trend of onset diabetes ", the aspect such as treatment by Chinese herbs principle mainly concentrates on pathogenic fire purging, pathogenic fire reducing, promotes the production of body fluid, YIN nourishing, the kidney invigorating, blood stasis dispelling, dredging collateral.

Chinese medicine is thought, climacteric syndrome is based on void, and kidney asthenia as the principal aspect, relates to the heart, liver, spleen, and thinks women's " YIN often being in shortage, YANG often being in excess ", clinical in the majority with deficiency of the kidney yin.Climacteric syndrome Chinese medical discrimination principle: the imbalance of qi depression to blood stasis, heart arteries and veins, heart deficiency of the kidney void, incoordination between the spleen and stomach; Therapeutic Principle: promotion of blood circulation, enriching yin and nourishing kidney, the spleen and stomach regulating, blood circulation promoting and blood stasis dispelling.

The beneficial effect adopting technique scheme to produce is:

(1) the present invention is with pure Chinese medicine side, has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promotion of blood circulation, enriching yin and nourishing kidney, the spleen and stomach regulating, has good curative effect to treatment diabetes and climacteric syndrome.Yellow wine has extraordinary dredge the meridian passage effect, and yellow wine contains the physiologically active ingredients such as polyphenol, melanoidin, glutathion, has scavenging free radicals, prevention cardiovascular diseases, anticancer, anti-ageing physiological function of waiting for a long time.The elite of the trace element in yellow wine and aminoacid and Chinese medicine produces good synergism, makes medicated wine of the present invention have good curative effect.

(2) medicine yellow wine of the present invention has safe and reliable, has no side effect, easily absorbs, instant effect, takes simple, can adjust the advantage of visceral peritoneum balance, 85% is reached to the cure rate of diabetes, 90% is reached to the cure rate of climacteric syndrome, also have the effect of prophylaxis of cancer simultaneously.

(3) medicine yellow wine of the present invention is because can treat diabetes and climacteric syndrome simultaneously, be particularly suitable for the diabetics entered into the climacteric period, because of diabetics enter into the climacteric period after can be disorderly due to hormone in vivo regulatory function, body carbohydrate tolerance reduces, and the regulating action of insulin to blood glucose weakens makes the more difficult control of blood glucose; Also climacteric syndrome patient can be prevented to suffer from diabetes.

For showing the therapeutic effect of medicine yellow wine of the present invention, use this medicine yellow wine that diabetes and climacteric syndrome patient are carried out to actual therapeutic and added up clinical observation data:

One, the clinical observation data of diabetes is treated:

1, case selection

Select Cao (female), teacher so-and-so (man) etc. 102 is the patient of diabetes through hospital diagnosis above county level, wherein male 49 example, women 53 is routine, age 40-62 year.All patients all have polydipsia, polyuria, weight loss and fasting glucose >=8.3mmol/L(150mg/dl in various degree).

2, efficacy assessment standard

Cure: transference cure after treatment, without recurrence in half a year, fasting glucose < 6.1mmol/L; 2 hours blood glucose < 7.2mmol/L after the meal; Twenty-four-hour urine sugar total amount < 5g;

Effective: after treatment, symptom disappears substantially, fasting glucose < 7.2mmol/L(130mg/dl), 2 hours blood glucose < 8.3mmol/L(150mg/dl after the meal), twenty-four-hour urine sugar total amount < 10.0g;

Effective: after treatment, symptom is obviously improved, fasting glucose < 8.3mmol/L(150mg/dl), 2 hours blood glucose < 10.0mmol/L(180mg/dl after the meal), twenty-four-hour urine sugar total amount < 25.0g;

Invalid: after treatment, symptom is not improved, blood glucose, glucose in urine decline and do not reach above-mentioned standard.

3, therapeutic scheme

The oral medicine yellow wine of the present invention of patient, twice daily, each 10 ~ 15mL, one after each meal.2 months is a course for the treatment of, takes 2-4 the course for the treatment of, and 4 courses for the treatment of add up therapeutic outcome.

4, statistical data is treated

Through adding up 102 routine diabetic therapy, curing number is 87 people, and cure rate is 85%; Total significant figure is 100 people, and total effective rate is 98%; Invalid number 2 people, inefficiency 2%.

5, model case:

Cao, female, 62 years old, heritability diabetes, fasting glucose > 20mmol/L, through in many ways failing to respond to any medical treatment, beating insulin, face was swollen, and lower limb is swollen, cardiac blood supply deficiency, gastropathy, and QI and blood is weak, kidney yin sun loss etc.Through taking medicine yellow wine of the present invention 7 days, insulin of stopping using, after 2 months, face lower limb is no longer swollen, takes after 8 months and cures, glucostasis, 2 years so far, without recurrence.

Lee so-and-so, female, 50 years old, diabetes+nephritis, 5 years medical histories, fasting glucose > 20mmol/L, urine protein 3g/L, hematuria: erythrocyte 3/HP in urine.Cure after 6 months through taking medicine yellow wine of the present invention, glucostasis, 1 year so far, without recurrence.

Teacher so-and-so, man, 55 years old, diabetes, 6 years medical histories, fasting glucose 15mmol/L, kidney yin sun loss, incoordination between the spleen and stomach, cardiac blood supply deficiency.Cure after 4 months through taking medicine yellow wine of the present invention, glucostasis, 1 year 0 two months so far, without recurrence.

Bai, man, 50 years old, diabetes, 2 years medical histories, fasting glucose > 10mmol/L, the loss of kidney yin sun, incoordination between the spleen and stomach.Cure after 4 months through taking medicine yellow wine of the present invention, glucostasis, 1 year so far, without recurrence.

Two, the clinical observation data of climacteric syndrome is treated:

1, case selection

Select so-and-so (female), Liu so-and-so (man) etc. 100 of merchant to be the patient of climacteric syndrome through hospital diagnosis above county level, wherein male 20 example, women 80 is routine, age 45-55 year.The symptoms such as all patients all have sweating, irritated, nervous, fatiguability, kidney yin sun loss.

2, efficacy assessment standard

Cure: sweating, the transference cures such as irritated, nervous, fatiguability, kidney yin sun loss, feel comfortable;

The symptoms such as effective: sweating, irritated, nervous, fatiguability, kidney yin sun loss alleviate;

Invalid: after taking medicine, the state of an illness is unchanged.

3, therapeutic scheme

The oral medicine yellow wine of the present invention of patient, twice daily, each 10 ~ 15mL, one after each meal, 2 months is a course for the treatment of, takes 2-4 the course for the treatment of, and 4 courses for the treatment of add up therapeutic outcome.

4, statistical data is treated

Through adding up 100 routine climacteric syndrome patient treatments, curing number is 90 people, and cure rate is 90%; Total significant figure is 97 people, and total effective rate is 97%; Invalid number 3 people, inefficiency 3%.

5, model case:

Go into business so-and-so, female, 49 years old, the loss of kidney yin sun, sweating, irritated, fatiguability, cardiac blood supply deficiency, nervous, breathe hard, incoordination between the spleen and stomach.Examine as climacteric syndrome, and have thyroid.Through take medicine yellow wine of the present invention after 2 months thyroid good, take after 4 months and fully recover, 2 years so far, without recurrence.

Liu so-and-so, man, 50 years old, the loss of kidney yin sun, kidney had cyst, sweating, irritated, fatiguability, cardiac blood supply deficiency, incoordination between the spleen and stomach, diarrhoea, nervous, breathes hard.Examine as climacteric syndrome.Breathing hard after 2 months through taking medicine yellow wine of the present invention, having taken heart after 4 months, taste are good, fully recovered after 6 months, 1 year so far, without recurrence.

Lee so-and-so, female, 48 years old, the loss of kidney yin sun, sweating, irritated, fatiguability, nervous, the deficiency of vital energy, cardiac blood supply deficiency, incoordination between the spleen and stomach, lumbago and skelalgia.Examine as climacteric syndrome.Through take medicine yellow wine of the present invention after 2 months taste good, take after 4 months and fully recover, 4 years so far, without recurrence.

Go into business so-and-so, female, 50 years old, the loss of kidney yin sun, sweating, and irritated, fatiguability, nervous, breathe hard, taste digestion is bad, gynaecopathia etc.Examine as climacteric syndrome, and have rheumatic heart disease.Do not feel any better through in many ways curing, through taking, medicine yellow wine of the present invention was breathed hard after 2 months, taste are good, took after 4 months and fully recovered, 2 years so far, without recurrence.

Revive so-and-so, female, 51 years old, the loss of kidney yin sun, sweating, irritated, fatiguability, nervous, the deficiency of vital energy, cardiac blood supply deficiency.Examine as climacteric syndrome, and have atrophic gastritis, metritis.Through take medicine yellow wine of the present invention after 1 month the deficiency of vital energy without, take metritis cancellation after 2 months, fully recover after 8 months, 1 year so far, without recurrence, also prevent the generation of cancer simultaneously.

Detailed description of the invention

Embodiment 1

A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 25g, Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 30g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Fructus Lycii 30g, Carapax Trionycis 30g, Herba Dendrobii 30g, Fructus Crataegi 30g, Fructus Chaenomelis 30g, Endothelium Corneum Gigeriae Galli 30g, Radix Polygalae 30g, Caulis Polygoni Multiflori 40g, Polyporus 25g, Rhizoma Alismatis 30g, Rhizoma Atractylodis 30g, Radix Scutellariae 30g, Herba Taraxaci 40g, Herba Houttuyniae 40g, Herba Leonuri 40g, Radix Salviae Miltiorrhizae 30g, Hirudo 25g, Radix Angelicae Sinensis 30g, Radix Rehmanniae Preparata 30g, Herba Portulacae 40g, Fructus Rosae Laevigatae 40g, Rhizoma Curcumae 30g, Rhizoma Sparganii 30g, Radix Achyranthis Bidentatae 30g, Rhizoma Chuanxiong 30g, Placenta Hominis 40g, get the Chinese medicine of above-mentioned weight proportion, be soaked in yellow wine, described yellow wine gross weight is 4 times of Chinese medicine gross weight, and soak time is 2h, then steams 3h at 90 ~ 100 DEG C, after cooling, is leached by Chinese medicine, obtains medicine yellow wine.

Embodiment 2

A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 20g, Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 35g, Radix Morindae Officinalis 35g, Herba Cistanches 25g, Fructus Lycii 35g, Carapax Trionycis 25g, Herba Dendrobii 25g, Fructus Crataegi 25g, Fructus Chaenomelis 35g, Endothelium Corneum Gigeriae Galli 35g, Radix Polygalae 35g, Caulis Polygoni Multiflori 35g, Polyporus 30g, Rhizoma Alismatis 35g, Rhizoma Atractylodis 35g, Radix Scutellariae 35g, Herba Taraxaci 35g, Herba Houttuyniae 35g, Herba Leonuri 35g, Radix Salviae Miltiorrhizae 25g, Hirudo 30g, Radix Angelicae Sinensis 35g, Radix Rehmanniae Preparata 25g, Herba Portulacae 45g, Fructus Rosae Laevigatae 35g, Rhizoma Curcumae 35g, Rhizoma Sparganii 35g, Radix Achyranthis Bidentatae 35g, Rhizoma Chuanxiong 25g, Placenta Hominis 35g, get the Chinese medicine of above-mentioned weight proportion, be soaked in yellow wine, described yellow wine gross weight is 3 times of Chinese medicine gross weight, and soak time is 1h, then steams 2h at 90 ~ 100 DEG C, after cooling, is leached by Chinese medicine, obtains medicine yellow wine.

Embodiment 3

A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 30g, Radix Astragali 35g, Rhizoma Atractylodis Macrocephalae 25g, Radix Morindae Officinalis 25g, Herba Cistanches 35g, Fructus Lycii 25g, Carapax Trionycis 35g, Herba Dendrobii 35g, Fructus Crataegi 35g, Fructus Chaenomelis 25g, Endothelium Corneum Gigeriae Galli 25g, Radix Polygalae 25g, Caulis Polygoni Multiflori 45g, Polyporus 20g, Rhizoma Alismatis 25g, Rhizoma Atractylodis 25g, Radix Scutellariae 25g, Herba Taraxaci 45g, Herba Houttuyniae 45g, Herba Leonuri 45g, Radix Salviae Miltiorrhizae 35g, Hirudo 20g, Radix Angelicae Sinensis 25g, Radix Rehmanniae Preparata 35g, Herba Portulacae 35g, Fructus Rosae Laevigatae 45g, Rhizoma Curcumae 25g, Rhizoma Sparganii 25g, Radix Achyranthis Bidentatae 25g, Rhizoma Chuanxiong 35g, Placenta Hominis 45g, get the Chinese medicine of above-mentioned weight proportion, be soaked in yellow wine, described yellow wine gross weight is 6 times of Chinese medicine gross weight, and soak time is 3h, then steams 2h at 90 ~ 100 DEG C, after cooling, is leached by Chinese medicine, obtains medicine yellow wine.

Embodiment 4

A kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome, it is steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 22g, Radix Astragali 27g, Rhizoma Atractylodis Macrocephalae 33g, Radix Morindae Officinalis 25g, Herba Cistanches 30g, Fructus Lycii 32g, Carapax Trionycis 25g, Herba Dendrobii 27g, Fructus Crataegi 32g, Fructus Chaenomelis 30g, Endothelium Corneum Gigeriae Galli 34g, Radix Polygalae 26g, Caulis Polygoni Multiflori 45g, Polyporus 22g, Rhizoma Alismatis 33g, Rhizoma Atractylodis 31g, Radix Scutellariae 34g, Herba Taraxaci 40g, Herba Houttuyniae 43g, Herba Leonuri 42g, Radix Salviae Miltiorrhizae 33g, Hirudo 21g, Radix Angelicae Sinensis 27g, Radix Rehmanniae Preparata 29g, Herba Portulacae 38g, Fructus Rosae Laevigatae 42g, Rhizoma Curcumae 33g, Rhizoma Sparganii 28g, Radix Achyranthis Bidentatae 28g, Rhizoma Chuanxiong 33g, Placenta Hominis 38g, get the Chinese medicine of above-mentioned weight proportion, be soaked in yellow wine, described yellow wine gross weight is 5 times of Chinese medicine gross weight, and soak time is 3h, then steams 3h at 90 ~ 100 DEG C, after cooling, is leached by Chinese medicine, obtains medicine yellow wine.

Claims (3)

1. treat the medicine yellow wine of diabetes and climacteric syndrome for one kind, it is characterized in that what it was steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 20 ~ 30 parts, the Radix Astragali 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 25 ~ 35 parts, Radix Morindae Officinalis 25 ~ 35 parts, Herba Cistanches 25 ~ 35 parts, Fructus Lycii 25 ~ 35 parts, Carapax Trionycis 25 ~ 35 parts, Herba Dendrobii 25 ~ 35 parts, Fructus Crataegi 25 ~ 35 parts, Fructus Chaenomelis 25 ~ 35 parts, Endothelium Corneum Gigeriae Galli 25 ~ 35 parts, Radix Polygalae 25 ~ 35 parts, Caulis Polygoni Multiflori 35 ~ 45 parts, Polyporus 20 ~ 30 parts, Rhizoma Alismatis 25 ~ 35 parts, Rhizoma Atractylodis 25 ~ 35 parts, Radix Scutellariae 25 ~ 35 parts, Herba Taraxaci 35 ~ 45 parts, Herba Houttuyniae 35 ~ 45 parts, Herba Leonuri 35 ~ 45 parts, Radix Salviae Miltiorrhizae 25 ~ 35 parts, Hirudo 20 ~ 30 parts, Radix Angelicae Sinensis 25 ~ 35 parts, 25 ~ 35 parts, Radix Rehmanniae Preparata, Herba Portulacae 35 ~ 45 parts, Fructus Rosae Laevigatae 35 ~ 45 parts, Rhizoma Curcumae 25 ~ 35 parts, Rhizoma Sparganii 25 ~ 35 parts, Radix Achyranthis Bidentatae 25 ~ 35 parts, Rhizoma Chuanxiong 25 ~ 35 parts, Placenta Hominis 35 ~ 45 parts.

2. a kind of medicine yellow wine for the treatment of diabetes and climacteric syndrome according to claim 1, it is characterized in that what it was steamed through yellow wine immersion by the Chinese medicine of following weight proportioning: Radix Ginseng 25 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Radix Morindae Officinalis 30 parts, Herba Cistanches 30 parts, Fructus Lycii 30 parts, Carapax Trionycis 30 parts, Herba Dendrobii 30 parts, Fructus Crataegi 30 parts, Fructus Chaenomelis 30 parts, Endothelium Corneum Gigeriae Galli 30 parts, Radix Polygalae 30 parts, Caulis Polygoni Multiflori 40 parts, Polyporus 25 parts, Rhizoma Alismatis 30 parts, Rhizoma Atractylodis 30 parts, Radix Scutellariae 30 parts, Herba Taraxaci 40 parts, Herba Houttuyniae 40 parts, Herba Leonuri 40 parts, Radix Salviae Miltiorrhizae 30 parts, Hirudo 25 parts, Radix Angelicae Sinensis 30 parts, 30 parts, Radix Rehmanniae Preparata, Herba Portulacae 40 parts, Fructus Rosae Laevigatae 40 parts, Rhizoma Curcumae 30 parts, Rhizoma Sparganii 30 parts, Radix Achyranthis Bidentatae 30 parts, Rhizoma Chuanxiong 30 parts, Placenta Hominis 40 parts.

3. a kind of preparation method for the treatment of the medicine yellow wine of diabetes and climacteric syndrome as claimed in claim 1 or 2, it is characterized in that: first by the herbal medicine immersion of described weight proportion in yellow wine, described yellow wine gross weight is 3 ~ 6 times of Chinese medicine gross weight, soak time is 1 ~ 3h, 2 ~ 3h is steamed again at 90 ~ 100 DEG C, after cooling, Chinese medicine is leached, obtain medicine yellow wine.