CN103721141A - External preparation for treating chronic eczema of scrotum and preparation method thereof - Google Patents

Abstract

The invention provides an external preparation for treating chronic eczema of scrotum and a preparation method thereof. The external preparation consists of the following bulk pharmaceuticals in parts by weight: 10-20 parts of Chinese gall, 10-20 parts of lightyellow sophora root, 10-20 parts of selinum japenious seed, 10-20 parts of spreading hedyotis herb, 10-20 parts of sinkiang arnebia root, 10-20 parts of densefruit pittany root-bark, 10-20 parts of glabrous greenbrier rhizome, 10-20 parts of dahurian patrinia herb, 10-20 parts of amur corktree bark, 10-20 parts of Chinese angelica, 10-20 parts of sessile stemona root, 10-20 parts of natural indigo, 10-20 parts of baikal skullcap root, 10-20 parts of common bletilla pseudobulb, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of safflower, 10-20 parts of rehmannia root and 10-20 parts of garden burnet root. The external preparation permeates into the body via the skin, and can reduce seepage, improve local flow of meridians and collaterals, directly reach skin lesions and accelerate skin healing. The external preparation can constrict skin blood vessels, slow down blood flow, decelerate metabolism, restrain effusion, effectively relieve pruritus and accelerate skin healing. A liquid medicament directly permeates into skin lesions, so that a good treatment effect is achieved.

Description

A kind of external preparation for the treatment of chronic eczema of scrotum and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of external preparation for the treatment of chronic eczema of scrotum and preparation method thereof.

Background technology

Scrotum is the position that man is ashamed of opening, yet, but the skin is here an eventful place.Scrotum is as male's privacy places, because physiology, and the reasons such as motion, dress, the abnormal sensory such as often can face humidity, pruritus, hyperhidrosis, humidity or send out cool.Scrotum has certain systolic and diastolic function, in its skin, there is a large amount of sweat glands, thereby can regulate local temperature, if the oozy perspiration of scrotum can not distribute in time, local temperature raises, sweat secretion increases, and will feel what scrotum always wet, and the scrotum of long-term hyperhidrosis humidity is easily produced inflammation and occurs that pruritus vulvae unbearably.Dampness of scrotum is one of classical symptom of chronic prostatitis, also with long-term sitting, in hot environment, work and varicocele relevant.Because skin of scrotum gauffer is more, sweat gland is more, and secretion power is strong, and air is difficult for circulation, wears the tight underwear trousers such as chemical fibre and can make ventilative situation become even worse.In addition, there is the patient of allergic constitution, be easy to because of various stimulations allergy, concurrent eczema scrotum.Again because diseased region is special, easily outbreak repeatedly, itches with play, to patient, brings very large misery and mental pressure simultaneously, and emotion changes is large, easily produces irritated.So be necessary it to carry out psychological counseling when carrying out clinical treatment, carry out the communication and education of medical knowledge, strengthen patient's confidence and willpower, allow patient get well early

The reason of eczema scrotum is more complicated, the people of allergic constitution, and the long-term people nervous, emotion changes big rise and fall of spirit easily suffers from primary disease; In addition, suffers from some diseases, the people of as not normal in chronic digestive system disease, gastrointestinal dysfunction, endocrine, dysbolism; Externally, under the effect of factor, also easily suffer from primary disease, as: the humid environment of life, work, the humidity ratio of air is larger; Environmental stimuli, cold or hot, perspire many, excessive scratch etc.; Underwear is tighter, or foreign body friction, and the underwear of wearing chemical fibre can bring out eczema scrotum.

Eczema scrotum is that a kind of common skin of scrotum is sick, is commonly called as " eczema of scrotum ", " scrotal eczema ".Its symmetrical generation, ordinary wave and whole scrotum, very itching in affected part, faces Cheng Chijiu, and outbreak repeatedly, is difficult for radical cure.Primary disease has anxious life, chronic dividing, and acute stage is equivalent to " erosive type ", and chronic phase is equivalent to " drying type ".Mostly scrotum generation pruritus is following reason: on eczema scrotum skin of scrotum, occur erythema, pimple, blister, erosion, ooze out, the multiple symptom such as incrustation, patient oneself feels scorching hot and pruritus.Often owing to firmly scratching, hot water laundering and occur acute swelling or erosion.This course of disease is longer, repeatedly shows effect and makes skin thickening, coarse, pigmentation, tinea cruris, skin of scrotum occur annular erythema, above has desquamation, has violent gargalesthesia.How patient suffers from tinea pedis (being commonly called as beriberi) or the tinea manuum simultaneously, and on the thigh skin of the scrotum offside of being everlasting, buttocks also has same symptom.

The topmost symptom of eczema scrotum is exactly painful hard to bear " itching ", especially from the environment of script high temperature humidity, while taking off the cooler temperature of trousers contacts, allow especially people be obliged to go to grab it, many people cannot resist and want the desire of grabbing, as a result, more grab skin just injured again and again, then skin just more becomes thicker, and skin thickening is just wanted to grab again, forms a vicious cycle.Treat clinically these disease doctors trained in Western medicine and adopt the medicines such as antiallergic, calmness, hormone more, as flat in dermatosis, daktarin, PIKANGWANG, the peaceful tincture of dermatosis etc.They are mostly the preparation of Western medicine chemical analysis, the patient shorter for sick time, symptom is lighter, and these medicines still have certain effect.But, the state of an illness heavier patient long for the course of disease, only there is temporary transient itching-relieving action in these medicines, the basic possibility without curing.Also some patient can produce certain drug resistance after long-time medication repeatedly, at this moment even itching-relieving action can not have yet.

Eczema scrotum is the comparatively common a kind of dermatosis of male, and the cause of disease is complicated, except patient's self body constitution, immunocompetence, also relevant with the factor such as extraneous physics, chemical irritation, therefore, in treatment disease, should carry out health mission work.The skin of scrotum is quite responsive, if be in high temperature, humidity, the poor environment of breathability, is easy to produce eczema.Therefore, cotton underwear loose, ventilative, absorbing sweat be should wear, pull-on pant and jeans avoided wearing for a long time.Many crowds that perspires summer should note carrying out skin clean health, and duty is had a bath, but should avoid scalding and alkaline soap with hot water, and duty is changed one's clothes, and keeps xerosis cutis.Should eat nutritious food more, eat vegetable and fruit more, drink more water, drink less, avoid seafood and irritating food such as pungent.Avoid scratching, in case infect or aggravation.The medicine of taking back, illustrate usage and points for attention to patient in detail, as soak method, coating method, service time and number of times and the untoward reaction that may occur and processing method etc.

Primary disease is mainly caused by following reason: local environment: for a lot of patients, particularly post operation of hypertensive cerebral hemorrhage, severe diabetes, multiple injuries, major operation etc. all can make body in hypermetabolism state, particularly catabolism strengthens, body malnutrition, cause hypoimmunity, the barrier protection function reduction of skin mucosa; In addition high heat, autonomic nervous dysfunction make excessive sweating, and scrotum place is moist.Nursing defects: scrotum position is special, is women mostly in nursery work, and therefore, it is moist that unsuitable cover causes scrotum place, and scrotum place skin clean is not thorough, does not note exposing affected part and all can make eczema scrotum occur or increase the weight of.Emotional factor: the normal combined language of post operation of hypertensive cerebral hemorrhage, limbs disturbance; Heavy craniocerebral injury is many by due to traffic accident and wound, the multifocal worry of patient, restless; Affected part pruritus, makes patient's mood irritated, causes and scratches, and erythra is increased the weight of.

Adopt now clinically and variously know Chinese medicine and western medicine or its mixture all fails to tackle the problem at its root, particularly life-time service some drugs can have side effects to skin and even whole body as steroid, and result is to cure the symptoms, not the disease, and loses more than gain.Also be no lack of still and cure various dermatosiss with some Chinese medicine clinically, but effect is also desirable not to the utmost.

Summary of the invention

Technical problem to be solved by this invention is, doctor trained in Western medicine steroid medicine is long for the course of disease, the heavier patient of the state of an illness, and these medicines only exist temporary transient itching-relieving action, the basic possibility without curing.Also some patient can produce certain drug resistance after long-time medication repeatedly; Prolonged application antibiotic in addition, destructible Body normal flora, causes relapse rate to raise; Do not have specific Chinese patent medicine.Clinically with Chinese physician, with disease foreign side, make decoction oral, and some Chinese medicine lotions, but therapeutic effect is all not satisfactory, exists and can bring out the deficiencies such as drug resistance, relapse rate is high, medication is inconvenient, preparation is difficult.Clinical in the urgent need to a kind of instant effect is provided, side effect is little, biocidal property is strong, the medicine of antipruritic effect treatment eczema scrotum rapidly, can efficient solution except patient's misery.

For solving the problems of the technologies described above, the invention provides a kind of external preparation for the treatment of chronic eczema of scrotum, in described external preparation, the parts by weight of various crude drug are: 10～20 parts of Galla Chinensiss, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Cortex Dictamnis, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Patriniae, 10～20 parts of Cortex Phellodendris, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Stemonae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Scutellariaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Saposhnikoviaes, 10～20 parts, Flos Carthami, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Radix Sanguisorbaes.

Treat according to claim 1 the external preparation of chronic eczema of scrotum, described in it, in external preparation, the parts by weight of various crude drug can be: 10～15 parts of Galla Chinensiss, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Fructus Cnidiis, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Radix Arnebiae (Radix Lithospermi)s, 10～15 parts of Cortex Dictamnis, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Herba Patriniae, 10～15 parts of Cortex Phellodendris, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Stemonae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Scutellariaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Saposhnikoviaes, 10～20 parts, Flos Carthami, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Radix Sanguisorbaes.

The external preparation of described treatment chronic eczema of scrotum, described in it, in external preparation, the parts by weight of various crude drug are also: 10～20 parts of Galla Chinensiss, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Cortex Dictamnis, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Patriniae, 10～20 parts of Cortex Phellodendris, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Stemonae, 10～15 parts of Indigo Naturaliss, 10～15 parts of Radix Scutellariaes, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Saposhnikoviaes, 10～15 parts, Flos Carthami, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Radix Sanguisorbaes.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the external preparation of chronic eczema of scrotum, and the preparation method that the dosage form of described medicine is unguentum comprises:

A, first crude drug to be cut into granule standby;

B, again the crude drug that is cut into granule is put into Oleum sesami, soak one day;

C, first with slow fire heating, when crude drug becomes when withered and yellow, the filtering of removing slag, calls in Cera Flava or Cera Flava, little fire is slowly received cream;

D, by system ointment in cold water, place 24 hours, releasing fire-toxin.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the external preparation of chronic eczema of scrotum again, and described external used medicine is gel, and its preparation method comprises the following steps:

A, first by crude drug ethanol extraction;

B, again raw material medicinal residues water after ethanol extraction is extracted;

C, by above-mentioned two kinds of extracting solution; Concentrated; Doped matrix is made gel.

In described step a, can be according to described parts by weight by crude drug soak with ethanol, rear 70～85 ℃ of heat are extracted, 10 times of amounts of the gross weight that ethanol consumption used is crude drug; Heating and refluxing extraction twice, each 1-2 hour, concentrated ethanol extract, is concentrated into relative density and is 1.08 concentrated solution, stand for standby use;

In described step b, the medicinal residues of the raw medicinal material that can more above-mentioned ethanol extraction be crossed add 10 times of water gagings, and heating and refluxing extraction 2 times each 1～2 hour, merges standing by 2 extracting solution.

In described step c, above-mentioned two kinds of extracting solution can be merged and filter, 1.35 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, extractum reduces pressure to obtain, after being heated to 40～50 ℃, stir, then add substrate, standing, be frozen into glue.

The substrate of the external preparation of described treatment chronic eczema of scrotum, can be selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

The external preparation of described treatment chronic eczema of scrotum, its external used medicine dosage form can have: tincture, unguentum, powder, powder, hip bath agent, lotion, gel and spray.

The present invention adopts the pharmaceutical compositions of heat clearing and damp drying, wind dispelling insecticide, promoting pus discharge and tissue regeneration strengthening, in skin penetrates body, strengthens therapeutical effect, has improved curative effect.Adopt Chinese herbs decoction soak, or make unguentum and use and can absorb sepage, improve local channels and collaterals running, the through skin lesion of efficacy of a drug affected part, accelerates skin lesion healing.The present invention can make skin heart shrink, and blood is slow, and metabolism lowers, and suppresses to ooze out and effective relieving itch, makes medicinal liquid directly infiltrate into skin lesion place, makes skin lesion healing acceleration, reaches therapeutic effect.Therefore, the present invention is alleviating the aspects such as scrotum flushing, sepage, swelling, and reduces recurrence, accelerates recovery from illness aspect, all has good market prospect.

The specific embodiment

Eczema scrotum is the modal dermatosis of scrotum, belongs to anaphylaxis, is also the common sexual organ's dermatosis of man, is not sexually transmitted disease.It is commonly called as " eczema of scrotum ", " acute scrotum eczema " etc.Plain stubborn, patient Chang Yin scratches, inadequate stimulus causes pain or secondary infection.Eczema scrotum former so more complicated, has internal factor, has again external factor.The people of allergic constitution, the long-term people nervous, emotion changes big rise and fall of spirit easily suffers from primary disease; In addition, suffer from some diseases, the people of as not normal in chronic digestive system disease, gastrointestinal dysfunction, endocrine, dysbolism, externally, under the effect of factor, also easily suffers from primary disease.Outside factor comprises: the humid environment of life, work, and the humidity ratio of air is larger; Environmental stimuli, cold or hot, perspire many, excessive scratch etc.; Underwear is tighter, or foreign body friction, and the underwear of wearing chemical fibre can bring out eczema scrotum.

The eczema scrotum traditional Chinese medical science is generally divided into two kinds of deficiency and excesss: real person is many because of damp invasion of lower energizer.Owing to usually having a liking for the pungent delicious food of food, or dampness of scrotum, perspiration infiltrates, underwear friction and causing., after scratching brokenly, there is the variations such as erosion is oozed out, incrustation in the visible pimple of scrotum, minor carbuncle, abscess, red red, the causalgia of skin of scrotum, and deficiency syndrome are many to be changed by acute stage, and skin of scrotum thickens, and coarse as careless, black, pruritus is unbearably.To the suitable clearing away heat-damp and promoting diuresis of the treatment of excess syndrome, deficiency syndrome are answered blood-nourishing skin-moisturizing.

Sui Dynasty Chao Yuanfang (550-630 A.D.) is recorded in < < General Treatise on the Cause and Symptoms of Diseases > >: " all skin ulcer persons of a specified duration, interior-heat is outer empty, by rheumatism is taken advantage of, women's head-ornaments health is all given birth to skin ulcer ".Ming Dynasty's Chen Shigong has supplemented improper diet, the cause of disease that interior life is damp and hot at < < Waike Zhengzong, Orthodox Manual of External Diseases > >.< < Ling Shu Miraculous Pivot or Divine Axis is determined in gas > > and is recorded: " part of the body cavity above the diaphragm housing the heart and lungs exploitation, a surname grain rice taste, fill body, pool hair at smoked skin, if irrigating of revealing of mist is meaning gas." < < Plain Questions the five internal organs generate piece of writing > > and say: " and lung close fur, its flourish mao is also." therefore during insufficiency of lung-QI skin lose nourish and cause dry matt, hair is withered, eczema very.From above-mentioned discussion, can find out that eczema is the card of " deficiency in origin and excess in superficiality ", " deficiency in origin " refers to asthenia of pulmonosplenic qi, and " mark real " refers to wind, wet, heat three is evil in suffering from, and adopts accordingly the method for " inside and outside rule together ".

Eczema scrotum patient from the beginning of time because this position belongs to privacy disease, be ashamed to mention, produce shy psychology, may delay treatment and nursing.When making the rounds of the wards, timely patient inquiry, publicity medical knowledge and health care knowledge, induce his positive partner treatment and nursing, and patient during late period, because the course of disease is long, shows effect repeatedly.Because the touching difficulty of primary disease heals, and generally patient is too shy to speak out, and feeling the night of being everlasting affects violent pruritus and have a rest, and is easy to occur agitation, anxiety, and anxiety, shortage patience, even flies into a rage and mismatches treatment nursing, is now the best opportunity of mental nursing.To hold a consultation in time according to the state of an illness, consult on the one hand, improve treatment care regimen; Will treat patiently on the other hand patient and will strengthen heart-to-heart talk comfort, that had both come pacifies it.Face disease rule, actively coordinate, firm confidence, the long-time psychology puzzlement of prevention patient, causes heart source property illness.

Though the non-serious symptom of eczema scrotum, but the site of pathological change that it is special, patient exists shy psychology at the initial stage of a disease, dare not remove hospital admission and buy voluntarily medicine treatment, due to inappropriate medication, cause aggravation, this not only affects patient's work, life, study, and caused serious mental burden, therefore carry out mental nursing extremely important.

Eczema scrotum is how relevant with emotion, patient Chang Yin disease location special, responsive and hiding one's sickness for fear for the treatment of, and delay treatment, in addition unclear to disease cognitive, be prone to shyly, the emotion such as anxiety, fear, anxiety.Therefore carry out before psychological counseling, accurately grasp psychological problems that patient exists and occupational characteristic, personality feature, living habit, schooling etc., for different problems, take corresponding measure, remove patient's thought misgivings, help it to establish the confidence of Fighting Disease.Nursing staff notes using sincere and honest, compassionate language and attitude, and dignified steady manner, with skilled nursing technique operation, win patient's trust, alleviate to greatest extent patient's mental burden, built the psychological environment of a gentle health, be beneficial to disease recovery.Strengthen the ventilation of living space.Cover thin and thick is moderate, take and does not perspire as degree, keeps perineal position clean dry, and duty is changed underwear, the duty quilt cover that more changes the sheet.Moist type eczema scrotum cover is unsettled, and drying type has thin crust or squama, the bits of not scratching or scale.

In side, Radix Sophorae Flavescentis has another name called Albizzia kalkora, cold in nature, and bitter in the mouth enters the heart, spleen, kidney three warps, has the effect of heat-clearing and toxic substances removing, dispeiling pathogenic wind and removing dampness.Modern medicine study shows: Radix Sophorae Flavescentis has good effect at antiviral, the aspect such as antibacterial, and has the function that reduces bacterial content, reaches the object of bacteria growing inhibiting; Cortex Phellodendri, bitter cold, heat clearing and damp drying, modern pharmacological research confirmation, Cortex Phellodendri has obvious antibacterial action to staphylococcus aureus, Streptococcus viridans etc.; Herba Hedyotidis Diffusae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni bitter cold, heat-clearing and toxic substances removing, expelling wind and removing dampness, compatibility Cortex Phellodendri is strengthened the effect of removing damp to relieve itching; Fructus Cnidii, Rhizoma Smilacis Glabrae, Galla Chinensis energy dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, Pseudobulbus Bletillae (Rhizoma Bletillae) heat-clearing and toxic substances removing, nourshing blood and promoting blood circulation, promotion local blood circulation, repair atrophy mucosa, strengthens the anti-damage ability of mucosa, local inflammation disappeared, Flos Carthami Radix Angelicae Sinensis, antipruritic effect and promoting granulation; All medicine compatibilities, take advantage of hot smoking to wash scrotum, make local symptom alleviate final healing.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Eczema scrotum is gynecological external use good medicine.< < Bencao Jingshu > > carries: Fructus Cnidii, and bitter in the mouth is flat; It is pungent sweet nontoxic that < < does not record > >; Modern its abnormal smells from the patient in detail, when the warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil.< < does not record > > warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet can strengthening the spleen, therefore can be except all deficiency and coldness of married woman man disease of viscera connecting with this channel that wets.Cold-damp was both removed, and disease is gone, performance Yiyang, thus disease, and have tonification also.

Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.< < Chinese Pharmacopoeia > > carries the power of Cortex Phellodendri heat clearing and damp drying, similar to Radix Scutellariae, Rhizoma Coptidis, but take damp and hot as good except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment eczema scrotum, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.

Herba Hedyotidis Diffusae is again Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature removing toxic substances, sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Be generally used for treatment sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also for the puckery pain of pyretic stranguria, dysuria.The good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

Herba Patriniae nature and flavor are bitter flat, have the effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Can cure acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the breast abdomen pain due to the excess-heat stasis of blood is stagnant, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Rhizoma Smilacis Glabrae is sweet, light, flat.Return liver, stomach warp.Function dehumidifying, removing toxic substances, easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, the limbs contracture due to mercurialism, muscles and bones contracture pain, scrofula, skin infection.Now be mainly used in clinically damp and hot sore, the compatibilities such as normal and Cortex Dictamni, the Fructus Kochiae, Radix Sophorae Flavescentis, Rhizoma Atractylodis are with use.

Radix Arnebiae (Radix Lithospermi) is cold in nature, sweet in the mouth, one-tenth.GUIXIN, Liver Channel.Cure mainly removing heat from blood, invigorate blood circulation, removing toxic substances rash.For heat in blood poison contain, macule purple is black, measles without adequate eruption, skin infection, dermatomycosis, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, dermatomycosis, hematuria, stranguria with blood, dysentery, skin infection, separates erysipelas.The just > > of < < book on Chinese herbal medicine carries: Radix Arnebiae (Radix Lithospermi), and abnormal smells from the patient bitter cold, and color purple enters blood, therefore the heat of cleaning blood system.Ancient to control the accumulation of heat of internal organs, descendant is special treatment of smallpox infections, and hold concurrently, treats skin eruption, all positive purport of heat clearing and blood cooling.

Cortex Dictamni is cold in nature, bitter in the mouth.Cure mainly heat clearing and damp drying, the removing toxic substances of dispeling the wind., dermatomycosis dripping for damp and hot sore, yellow fluid, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.The normal medicines such as Radix Sophorae Flavescentis, the Fructus Kochiae that coordinate are with using.The original > > of < < book on Chinese herbal medicine carries it: " control all mange, aversion to wind, scabies, Fructus Myricae rubrae, all skin ulcer pyretic toxicity.″

Galla Chinensis meridian distribution of property and flavor: sour in the mouth is puckery, cold in nature.Return lung, large intestine, kidney channel.< < detailed outline > >: the pathogenic fire reducing of astringing the lung, the drink that reduces phlegm, cough-relieving is coughed, quench one's thirst, night sweat, vomiting, lose blood, chronic dysentery, jaundice, cardiac and abdominal pain, the nocturnal fretfulness in infants, controls eye red wet rotten, detumescence poison, sore throat, hold back routed skin ulcer, incised wound, receive under proctoptosis, sub-intestinal pendant.Antibacterial action: in vitro tests all has significantly antibacterial or bactericidal action to staphylococcus aureus, streptococcus, streptococcus pneumoniae and typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, bacillus pyocyaneus etc.Galla Chinensis still contains other antibiotic effective ingredients except tannic acid, is mainly distributed in skin zone, and the decoct of the Galla Chinensis heart is without antibacterial action.Galla Chinensis decoct has inhibitory action to being inoculated in the influenza PR8 strain of influenza virus type A virus of Embryo Gallus domesticus, may be with wherein contained tannic acid is relevant.The flat board method that burrows for 100% decoct, bacillus pyocyaneus, dysentery bacterium, Bacillus proteus, escherichia coli, Bacillus typhi, bacillus enteritidis, anthrax bacillus, diphtheria corynebacterium, staphylococcus aureus, group B streptococcus and streptococcus pneumoniae are all had to inhibitory action, its bacteriostasis is not the acidity due to tannic acid, but because of it, albumen is had to consolidation; Galla Chinensis liquid after ether proposes tannin still has antibacterial action.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.For hemoptysis, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.< < Sheng Nong's herbal classic > >: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; < < Compendium of Materia Medica > >: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, to the passive general allergy of Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Indigo Naturalis: salty in the mouth cold in nature, return Liver Channel.There is heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, the effect of pathogenic fire purging arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.Bacteriostasis: couroupitine A is tested through antifungal, active component for antidermatosis fungus, it is 5 μ g/ml that microsporum canis, disconnected tineatonsurans, microsporon gypseum, purple tinea bacterium, trichophyton gypseum, red mentagrophytes, acrothesium floccosum etc. are all had to stronger inhibitory action, its minimal inhibitory concentration., < < Bencao Jingshu > >: " Indigo Naturalis; removing toxic substances heat extraction; Gu its chief; more ancient prescription has and be used for all blood disorder persons, make non-blood system excess-heat, and diease occurrence is in yin asthenia generating intrinsic heat; YANG unable to attach to somewhere; fire of moxibustion, because of scorching in void, sent out as telling to be defeated in battle and coughed up the cards such as saliva, non-suitable with it.Blood must be trembled with fear solidifying, and solidifying cold and heat are handed over and done, and chest and diaphragm or pain, more increase its disease.

Radix Stemonae nature and flavor are sweet, bitter, tepor.Return lung meridian.Cure mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.For new chronic cough, cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.The infusion of Radix stemonae japonicae and other kind Radixs Stemonae and ethanol immersion, mosquitos and flies larva, head louse, clothing louse and Cimex bedbug etc. are all had to killing action, alcohol preserved material compared with the effect of water logging agent for large. 50% distilled water suspension contact pubic louse number minute of Radix Stemonae ethanol soluble extraction can be killed, and infusion is invalid. stronger than DDT and Pyrethrum by the behead effect of louse and pubic louse of 70% alcohol leaching liquid. the high concentration Radix Stemonae has the effect of killing Mus pinworm in vitro.< < Bencao Shiyi > >: fire is processed infusing drugs in wine and drunk on an empty stomach, and debug silkworm stings, the scabies skin ulcer of holding concurrently.

Flos Carthami promoting blood circulation to restore menstrual flow, scattered silt pain relieving, for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.Test: 15 rats are divided into 3 groups, respectively ip1100mg/kg Carthamus yellow, hydrocortisone 20mg/kg and normal saline.After administration 30 minutes, in left and right, the foot sole of the foot sc2.5% of portion formalin 0.05ml caused inflammation, cause scorching after 1.3.5.7.24 hour, for minute chi, measure the swollen thickness of rat foot, and with cause the swollen Thickness Ratio of foot before inflammation, calculate the foot swelling rate of each medicine group different time.The foot swelling of result Carthamus yellow PARA FORMALDEHYDE PRILLS(91,95) has obvious inhibitory action (P < O.001).

Radix Saposhnikoviae returns urinary bladder channel; Lung meridian; Spleen channel; Liver Channel expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.< < Japan hanako materia medica > >: wind as controlling 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, wins and damages night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse., < < Bencao Jingshu > >: it is general that Radix Saposhnikoviae is controlled wind, liter is sent out and can be fallen apart, therefore main large dizziness due to wind pain, aversion to wind ailment said due to cold or exposure, whole body arthralgia numbness, hypochondriac pain, side of body public attention face go, and extremity contraction is anxious, stimulating milk secretion, incised wound is convulsion in wind due to wound.Its cloud argument is without finding person, because of in ailment said due to cold or exposure, therefore lose also.Stuffy sensation with restlessness person, because ailment said due to cold or exposure visitor is in the heart, therefore stuffy sensation with restlessness also.Wind, cold, wet three closes and forms numbness, and dispeiling pathogenic wind and removing dampness, therefore main numbness also.Here the medicine of dispersing, can take for a long time, and it is said and makes light of one's life by commiting suicide, also the wet ear that goes.< < does not record > > cloud, and jaw person makes us going mad, and fork-tail person sends out obstinate disease, and son is like Herba Coriandri and large, adjusts edible perfume and treatment wind is more also excellent.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.With respect to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect, every blood system to have the people of thermal burn the moon to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., can often take.

Radix Sanguisorbae cures mainly haematemesis, spitting of blood, and epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.< < detailed outline > >: Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, control defecation blood disorder.Hemostasis, gets and cuts off sheet and fry use, and its tip can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Externally used paste of the present invention:

According to described ratio of weight and number by Galla Chinensis 1000g, Radix Sophorae Flavescentis 1000g, Fructus Cnidii 1000g, Herba Hedyotidis Diffusae 1000g, Radix Arnebiae (Radix Lithospermi) 1000g, Cortex Dictamni 1000g, Rhizoma Smilacis Glabrae 1000g, Herba Patriniae 1000g, Cortex Phellodendri 1000g, Radix Angelicae Sinensis 1000g, Radix Stemonae 1000g, Indigo Naturalis 1000g, Radix Scutellariae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Saposhnikoviae 1000g, Flos Carthami 1000g, Radix Rehmanniae 1000g, Radix Sanguisorbae 1000g, mixes by proportioning, first crude drug is cut into granule standby; Again the crude drug that is cut into granule is put into Oleum sesami, soak one day, first with slow fire heating, when crude drug becomes when withered and yellow, the filtering of removing slag, calls in Cera Flava or Cera Flava, and little fire is slowly received cream; By system ointment in cold water, place 24 hours, releasing fire-toxin.

Cera Flava is the wax of Apis secretion, has the function of astringent therapy, sore, granulation promoting, pain relieving, outward for ulcer being unable to heal, ecthyma erosion, wound, burn and scald etc., suppresses local organization inflammation, promotes histiocyte growth, accelerates the healing of ulcer skin.Pharmacological testing proof Cera Flava extracting solution has parallel antibacterial action to bacillus larvae, honeycomb bacillus.Cera Flava is commonly used for the substrate of excipient and the external-use ointment of Chinese patent medicine.Cera Flava is used as medicine and can regulates soft durometer as the substrate of ointment, improves release and the absorption of medicine.In Chinese medicine ointment of the present invention, Cera Flava, in performance convergence, granulation promoting pain relieving drug effect, also serves as the effect of substrate.

The preparation method of gel of the present invention: by Galla Chinensis 1500g, Radix Sophorae Flavescentis 1500g, Fructus Cnidii 1500g, Herba Hedyotidis Diffusae 1500g, Radix Arnebiae (Radix Lithospermi) 1500g, Cortex Dictamni 1500g, Rhizoma Smilacis Glabrae 1500g, Herba Patriniae 1500g, Cortex Phellodendri 1500g, Radix Angelicae Sinensis 1500g, Radix Stemonae 1500g, Indigo Naturalis 1500g, Radix Scutellariae 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Saposhnikoviae 1500g, Flos Carthami 1500g, Radix Rehmanniae 1500g, Radix Sanguisorbae 1500g, chopping joins in multi-function extractor, add water soaking 30～40 minutes, decoct twice, each 30～45 minutes, twice decoction liquor merged and filtered, filtrate decompression is concentrated, staticly settle 24～48 hours, draw supernatant, stir after being heated to 40～50 ℃, under normal pressure, be condensed into ratio of weight and number and be the concentrated solution of 500 parts, add substrate, standing, be frozen into glue.Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

General substrate used can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, the proportioning of medicine fine powder and substrate is 1: 2～1: 4, be preferably 1: 3, or adopt poloxamer poloxamer as substrate, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: the dissolubility than other substrate is soft, quick, and drug loading is also higher.

The preparation method of powder of the present invention:

By Galla Chinensis 1500g, Radix Sophorae Flavescentis 1500g, Fructus Cnidii 1500g, Herba Hedyotidis Diffusae 1500g, Radix Arnebiae (Radix Lithospermi) 1500g, Cortex Dictamni 1500g, Rhizoma Smilacis Glabrae 1500g, Herba Patriniae 1500g, Cortex Phellodendri 1500g, Radix Angelicae Sinensis 1500g, Radix Stemonae 1500g, Indigo Naturalis 1500g, Radix Scutellariae 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Saposhnikoviae 1500g, Flos Carthami 1500g, Radix Rehmanniae 1500g, Radix Sanguisorbae 1500g puts into ethanol heating extraction 2 times, and each 1-2 hour by the quiet stand for standby use of extracting solution; Medicinal residues are decocted with water 2 times, each 1-2 hour, mixes decoction liquor again; Then after said extracted liquid being mixed, heating is condensed into pasty state, is dried to powder, use and be constantly directly applied in affected part, or the spray of heating is split into lotion, immersion every day.

Toxicology test:

One, acute oral toxicity test report

1, experiment purpose: acute oral toxicity effect and the intensity of powder of the present invention to mice

2, materials and methods:

2.1. tested material: powder of the present invention; Character: pitchy powdery

2.2. sample pre-treatments: take 15 duplicate samples, add 500ml boiled water, soak 2 hours, as stock solution.

2.3. experimental animal: one grade of Kunming mouse, 40, female, male half and half, body weight 18-23 gram; By University Of Qingdao's Experimental Animal Center, provided;

3, test method: (a time maximum limit is mensuration)

Select 40 of healthy adult mices, body weight 18-23 gram, female, hero half and half, dosage design is female is 6000m part/k part BW, male is 6000m part/k part BW, by 0.1ml/10 part BW per os gavage, gives tested material.Before gavage, animal fasting is 12 hours, freely drinks water.After gavage, give normal diet, observe 3 weeks, record poisoning symptom and death condition.

4, result of the test:

In 21 day observation period, animal subject is without abnormal response, without death, postmortem no abnormality seen.

5, conclusion:

According to acute toxicity grading criteria in < < disinfection technology standard > > (1999), judge the nontoxic level in the true border of powder of the present invention.

Two, acute skin irritation test report

1, experiment purpose: detect unguentum to the stimulation/corrosiveness of laboratory animal skin and intensity

2, materials and methods:

2.1. tested material: title: unguentum of the present invention

2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; By Affiliated Hospital of Qingdao University biology department Experimental Animal Center, provided;

2.3. test method:

Select 10 of the healthy rabbits that skin is intact, in test, its spinal column both sides, back were cut in first 24 hours to left and right each the about 4cm * 4cm of unhairing area by hair.During test, get on two layers of gauze that tested material 0.2ml is applied to 2.5cm * 2.5cm, be applied to a side skin of unhairing surface, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Seal after 4 hours, dismantle, and clean and go residual tested material with warm water, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and scoring.

3, experimental result: any erythema does not appear in laboratory animal skin, redness, inflammation phenomenon.

4, brief summary: judge according to skin irritation reaction standards of grading in < < disinfection technology standard > > (1999), ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Three, skin anaphylactic test

1.1 skin anaphylactic tests: 40 Cavia porcelluss are equally divided into 4 groups: 1. matched group, 2. 3. 4. cydiodine group (1% sensitization concentration and 0.1% excite concentration) of metronidazole group of unguentum group of the present invention.

1.2 sensitization contact: before test, 24h, in guinea pig back both sides, carefully cuts the unhairing district of 3cm * 3cm.Get tested material 0.2ml, be coated in depilation district, animal left side, with one deck oilpaper and two layers of gauze, cover, then with non-stimulated adhesive plaster sealing, fixing, keep 6h.The 7th day and the 14th day, in kind respectively repeat 1 time, amount to 3 times.Blank group and positive drug matched group method the same (the sensitization concentration of cydiodine and metronidazole 1% for positive sensitizer, matched group is coated with the normal saline that gives equivalent).

1.3 excite contact: after last administration tested material sensitization 14 days, tested material 0.2ml is applied to depilation district, Cavia porcellus right side, positive control 0.1% metronidazole, after 6h, remove tested material, at once observe, then in 24,48, again observe skin allergy situation after 72h, by the scoring of table 1 standard, and evaluate sensitization degree.

Table 1 skin allergy degree standards of grading

1.4 skin anaphylactic test results

With unguentum of the present invention, be example, induce and excite contact test, viewing test mice after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this unguentum is bordering on zero to dermoreaction intensity, without skin allergic reaction.

Liniment of the present invention (powder of the present invention adds ethanol) is smeared to mouse vagina, induce and excite contact test, viewing test mouse vagina after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this liniment is bordering on zero to dermoreaction intensity.

Pharmacodynamics test

Experiment material:

1, tested material and medicine: (1) externally used paste of the present invention (embodiment preparation method preparation used) (2), the clean washing liquid of Cortex Phellodendri skin, E Wei disappears and demonstrate,proves No. 0022 (3) Piyanping ointment of word (2009), three nine-day periods after the winter solstice, pharmaceutical factory produced, commercially available.

2, animal: 50 of Kunming mouses, regular grade body weight 18～24g, animal housing of University Of Qingdao provides; Wistar rat, regular grade, body weight 150～350g, biotic experiment animal housing of University Of Qingdao provides; 50 of Cavia porcelluss, body weight 200～300g, animal housing of University Of Qingdao provides.Animal male and female are all used.

Experimental technique and result:

One, the effect to drug-induced animal skin pruritus

1, dextran is caused the impact of mouse skin pruritus

50 of mices, 5 groups of random packet: (1) blank group (distilled water 20ml/kg); (2), the clean washing liquid group of Cortex Phellodendri skin (4mg/kg); (3), PIYANPING group (2mg/kg); (4), medicine low dose group of the present invention (3mg/kg, in crude drug amount); (5), medicine high dose group of the present invention (6mg/kg).

Each organize mice respectively administration smear, after 30min, iv dextran 1 .25mg/kg, records in 20 minutes total degree and lasting total time that every mice pruritus occurs.

Result shows, medicine of the present invention has obvious itching-relieving action to dextran induced mice skin pruritus, in Table 1.Relatively there is significant difference (P < 0.01) with blank group.

Table 1 medicine of the present invention is on the impact of dextran induced mice skin pruritus (X ± SD)

Make t check, * P > 0.05, * * * P < 0.01 with blank group

Result shows, the present invention is low, high dose group all has good antipruritic effect.

Two, histamine is caused the impact of Cavia porcellus pruritus

50 of Cavia porcelluss, hair is shaved on every Cavia porcellus rear right instep, and uses sand paper scratch mark, the about 1cm2 of area, subsequently animal random packet: (1) blank group (10ml/kg, ig); (2) the clean washing liquid group of Cortex Phellodendri skin (4mg/kg, ig); (3) PIYANPING group (2mg/kg, ig); (4) medicine externally used paste low dose group of the present invention (3mg/kg); (5) medicine externally used paste high dose group of the present invention (6mg/kg).

Every Cavia porcellus is dripped 0.01% histamine liquid at rear right foot wound surface, after this every 3 minutes according to 0.01%, 0.02%, 0.03%, 0.04%...... progressive concentration, only be 0.05ml/ at every turn, directly cause and occur that Cavia porcellus later licks rear right foot, take and finally occur that the histamine total amount that Cavia porcellus is given while later licking rear right foot is itch-threshold.

Result shows, medicine 3mg/kg dosage group of the present invention can obviously improve itch-threshold, in Table 2.Relatively there is significant difference (P < 0.01) with blank group.

The impact (X ± SD) of table 2 medicine of the present invention on guinea pig skin pruritus reaction due to histamine

Make t check, * P > 0.05, * * P < 0.05, * * * P < 0.01 with blank group

Three, the impact of the present invention on the subacute contact eczema model of Wistar rat

By 24 of Wistar rats, be divided at random 4 groups, 6 every group, male and female half and half: model group (external-use substrate), unguentum group of the present invention (being called for short unguentum group, concentration 20%), the clean washing liquid group of Cortex Phellodendri skin (concentration 30%), PIYANPING group.

Set up 24 subacute contact eczema models of Wistar rat.Every the Wistar rat nape cropping 3cm*3cm of portion size, with the outer painting sensitization of 5%DNCB solution 25.After 2 weeks, the backside 0.1%DNCB solution 100ml of every Wistar rat, as exciting, 5 times weekly, continuous 4 times.The 4th excites rear 72h, by the Wistar rat of model group, of the present invention group, the clean washing liquid group of Cortex Phellodendri skin and PIYANPING group external-use substrate 0.12g respectively, 0.12g of the present invention, the clean washing liquid group of Cortex Phellodendri skin 0.1ml, Piyanping ointment 0.1g, every day 2 times, continuous 10 days.1 day test and appraisal chorionitis sexual cell counting after drug withdrawal: get fritter skin histology, specimens paraffin embedding slices, hematoxylin-eosin (HE) dyeing, counts respectively 10 high power fields (HPF) corium number of inflammatory cells, gets its meansigma methods.

The impact (x ± s) of table 3 different pharmaceutical external on the subacute contact eczema model of DNCB induction Cavia porcellus

Group	Thickness difference/mm	Weight difference/mg	Corium number of inflammatory cells
				Model group	0.118±0.43	0.337±0.213	108.3±15.3
Of the present invention group	0.064±0.147	0.162±0.112	72.5±14.7
				The clean washing liquid group of Cortex Phellodendri skin	0.045±0.089	0.182±0.051**	87.2±24.3*
PIYANPING group	0.065±0.084	0.165±0.178**	73.3±13.5**

Note: * is with model group ratio, P < 0.05, and * * is with model group ratio, P < 0.01.

Conclusion: show that the present invention and Piyanping ointment cause the effect that has inhibition corium inflammatory cell infiltration on the subacute contact eczema model of Cavia porcellus at DNCB.

Clinical data

The eczema scrotum often course of disease is long, easily repeatedly, adds that insufferable play itches, and site of pathological change particularity, to patient, brings very large misery.2009～2012 undergraduate courses are for the pathogeny of eczema scrotum, skin lesion situation, and mental statuss etc., adopt treatment by Chinese herbs method treatment eczema scrotum inpatient, obtain more satisfied curative effect, existing that report the test is as follows.

1, data and method

1.1 ordinary circumstances: case is all from the court's surgical wards surgical patient, according to the diagnosis of < < common disease and efficacy evaluation (standard) > >, observe altogether the combined postoperative eczema scrotum patient that 130 examples have been made a definite diagnosis, patient is previously without eczema medical history, after operation, in 4～12 days, there is scrotum position acute eczema, skin lesion is intensive red pimple, be dispersed in vesicle, there is rotten to the corn face, there are a large amount of sepages, while there is local infection owing to scratching in some patients were, the visible pus pimple that is dispersed in.There is repeatedly reaching a wheat harvesting period.Gastrectomy patient 46 examples wherein, scrotal varices patient with operation 34 examples, splenectomy 8 examples, intestinal obstruction postoperative patient 4 examples, polyp intestinal patient with operation 3 examples, appendectomy patient's 4 examples, hepatic cyst excision patient 6 examples, hemorrhoidectomy patient's 12 examples, varicose veins of the lower extremity ligation patient 13 examples.

Get rid of and suffer from connective tissue disease, tuberculosis, chronic active hepatitis person, merge cardiovascular, liver, renal damage person, have the serious primary disease person such as brain and hemopoietic system; Psychotic; To medicine allergy sufferers; Therapist in accordance with regulations not; Cannot judge that curative effect or data do not affect the treatment or safety judgement person entirely.130 routine patients are divided into treatment group 80 examples at random, matched group 50 examples, the treatment group case course of disease 20～30 days, 19～66 years old age, the matched group course of disease 25～35 days, at 19～65 years old age, two groups of patients' age, the course of disease, skin lesion situation and subjective symptoms etc. all have comparability.

1.2 Therapeutic Method: the oral loratadine tablet 10mg of matched group, 1 time/d, vitamin B2 sheet 10mg, 2 times/d, when, there are a large amount of rotten to the corn faces and sepage acute stage with 3% borate soak, 4 times/d, sepage stops with triamcinolone acetonide econazole ointment, smearing afterwards, 1～2 time/d 10 days was 1 course for the treatment of, observe the curative effect after 3 courses for the treatment of.The oral loratadine tablet 10mg for the treatment of group, 1 time/d, vitamin B2 sheet 10mg, 2 times/d, with Chinese herbs decoction soak of the present invention, prescription is as follows: Galla Chinensis 10g, Radix Sophorae Flavescentis 12g, Fructus Cnidii 11g, Herba Hedyotidis Diffusae 12g, Radix Arnebiae (Radix Lithospermi) 13g, Cortex Dictamni 11g, Rhizoma Smilacis Glabrae 12g, Herba Patriniae 11g, Cortex Phellodendri 12g, Radix Angelicae Sinensis 11g, Radix Stemonae 12g, Indigo Naturalis 11g, Radix Scutellariae 11g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Radix Saposhnikoviae 12g, Flos Carthami 12g, Radix Rehmanniae 12g, Radix Sanguisorbae 11g, filters after adding water boil 30min, goes out medicinal liquid and cools.With 6 layers of cotton pad soaking medicated liquid of gauze, take and do not drip as degree, be close to affected part, and fix with T bandage, every 2h is change dressings 1 time more, to keep cotton pad humidity.If while being associated with purulent secretion, should every 1h change dressings 1 time more, as after skin lesion wound exudate reduces, can be made into paste application, 1～2 time/d 10 days was 1 course for the treatment of, observe the curative effect after 3 courses for the treatment of.

1.3 mental nursings: when carrying out above treatment, patient is carried out to necessary mental nursing, eczema scrotum patient from the beginning of time because this position belongs to privacy disease, be ashamed to mention, produce shy psychology, may delay treatment and nursing.When making the rounds of the wards, timely patient inquiry, publicity medical knowledge and health care knowledge, induce his positive partner treatment and nursing, and patient during late period, because the course of disease is long, shows effect repeatedly.Because the touching difficulty of primary disease heals, and generally patient is too shy to speak out, and feeling the night of being everlasting affects violent pruritus and have a rest, and is easy to occur agitation, anxiety, and anxiety, shortage patience, even flies into a rage and mismatches treatment nursing, is now the best opportunity of mental nursing.To hold a consultation in time according to the state of an illness, consult on the one hand, improve treatment care regimen; Will treat patiently on the other hand patient and will strengthen heart-to-heart talk comfort, that had both come pacifies it.Face disease rule, actively coordinate, firm confidence, the long-time psychology puzzlement of prevention patient, causes heart source property illness.

1.4 curative effect determinate standards: fully recover for skin lesion all disappears, pruritus stops; Effective for skin lesion disappears area > more than 80%, pruritus stops substantially; Effectively, for skin lesion disappears area > more than 50%, pruritus alleviates; Invalid is the skin lesion area < 50% that disappears, or skin lesion shows effect repeatedly, and pruritus is without obviously alleviating.Effective percentage adds effective in recovery from illness.

2, result

2.1 therapeutic outcomes: in Table 1.Two groups of effective percentage comparing differences have statistical significance (X ²=10.539, P < 0.05).

Table 1, two groups of therapeutic outcome comparisons

Group

Number of cases

Recovery from illness

Effective

Effectively

Invalid

Effective percentage (%)

Treatment group	80	43	22	10	5	93.75
							Matched group	50	19	14	7	10	80

2.2, untoward reaction: two groups of patients are showed no obvious untoward reaction.

3, discuss

Surgical Inpatients usually needs bed or the restraint of long period after operation, if clothing tension, breathability is poor, foreign body friction, or wear chemical fibre class clothing and all can cause part airtight, easily moist, at the position that approaches defecation passage, the poor eczema of easily bringing out of sanitary condition, especially in 5 annual～October, temperature is too high, and the eczema scrotum of specific part more easily occurs.Eczema scrotum mainly betides scrotum and near skin thereof, is a kind of delayed allergy causing due to the inside and outside motivating factor of complexity.

The eczema scrotum traditional Chinese medical science claims the kidney-wind syndrome, and eczema of scrotum is to be attacked and form outward by rheumatism, and due to damp invasion of lower energizer pents up, motherland's medical science is thought in treatment, suitable clearing away heat-damp and promoting diuresis, and dispelling wind for relieving itching, it is rule that removing toxic substances is dispelled dry.The Chinese herbs decoction soak nursing that we adopt is to arrange according to the principle of tcm treatment according to syndrome differentiation.

Radix Sophorae Flavescentis energy eliminating damp-heat in side, removing pathogenic heat from blood and toxic substance from the body, wind dispelling insecticide; Fructus Cnidii, the Radix Stemonae can be controlled damp and hot, temperature poison, loose wind heat clearing away; Radix Saposhnikoviae is controlled many ailment said due to cold or exposure, the wind of the solid body of dispelling; Cortex Dictamni cures mainly eczema and itches; The Galla Chinensis removing toxic substances of can stopping blooding; The sterilization of Cortex Phellodendri clearing away damp-heat; Rhizoma Smilacis Glabrae removing toxic substances is except damp and hot; Radix Angelicae Sinensis dampness removing to stop itchin.Simultaneously oral loratadine energy antihistaminic desensitization is antipruritic, and vitamin B2 is supplemented riboflavin.

Adopt Chinese herbs decoction soak, can absorb sepage, improve local channels and collaterals running, the through skin lesion of efficacy of a drug affected part.The medicinal liquid fried with above all medicines carries out soak, can make skin heart shrink, and blood is slow, and metabolism lowers, and suppresses to ooze out and effective relieving itch, makes medicinal liquid directly infiltrate into skin lesion place, reaches therapeutic effect.Therefore, Chinese medicine preparation is alleviating the aspects such as scrotum flushing, sepage, swelling, and reduces recurrence, accelerates recovery from illness aspect, is all better than matched group.

In addition, there is the patient of allergic constitution, be easy to because of various stimulations allergy, concurrent eczema scrotum.Again because diseased region is special, easily outbreak repeatedly, itches with play, to patient, brings very large misery and mental pressure simultaneously, and emotion changes is large, easily produces irritated.So be necessary it to carry out psychological counseling when carrying out clinical treatment, carry out the communication and education of medical knowledge, strengthen patient's confidence and willpower, allow patient get well early.

Specific embodiment 1: Wu, man, 43 years old.In June, 2009 is medical.Patient tells dampness of scrotum in recent years, and pruritus is shown effect repeatedly, aggravates 15 days.Companion's inappetence, stool malt sugar.Have a medical check-up: see that the front inner side of right leg and scrotum place pachyderma are coarse, desquamation, pigment is darker, has obvious scratch, and blood stain is obvious.Tongue tip side of red, yellow and greasy fur, thready and rapid pulse.Be diagnosed as: chronic eczema of scrotum.External: Galla Chinensis 10g, Radix Sophorae Flavescentis 12g, Fructus Cnidii 12g, Herba Hedyotidis Diffusae 12g, Radix Arnebiae (Radix Lithospermi) 13g, Cortex Dictamni 12g, Rhizoma Smilacis Glabrae 12g, Herba Patriniae 11g, Cortex Phellodendri 12g, Radix Angelicae Sinensis 11g, Radix Stemonae 12g, Indigo Naturalis 11g, Radix Scutellariae 11g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Radix Saposhnikoviae 13g, Flos Carthami 13g, Radix Rehmanniae 12g, Radix Sanguisorbae 11g, makes powder, every day, soaked demibain was 2 times, and after 2 days, scratchiness obviously alleviates, after the week, sleeping evening, no longer pruritus is hard to bear, without hands, scratches, and skin lesion starts to improve, 2 the course for the treatment of skin lesion be completely recovered.Follow up a case by regular visits to not recurrence so far.

Specific embodiment 2: land, man, 52 years old, in January, 2011 was medical, main suit: it is peppery that itself likes food, good tobacco and wine; Have hemorrhoid, chronic prostatitis, often feels dampness of scrotum, very itch evening in bed, scratches brokenly, and pruritus is shown effect 5 years repeatedly, aggravation recently 10 days, there is large stretch of erythema in scrotum surrounding skin, or has dense like foxtail millet grain size pimple, visible point-like is rotten to the corn, has serosity to ooze out, with pruritus or scorching hot Burning Pain sense, thirst with desire to drink, constipation with dry stool, yellowish or reddish urine, deficient, is diagnosed as: chronic eczema of scrotum.External: Galla Chinensis 12g, Radix Sophorae Flavescentis 12g, Fructus Cnidii 12g, Herba Hedyotidis Diffusae 12g, Radix Arnebiae (Radix Lithospermi) 13g, Cortex Dictamni 12g, Rhizoma Smilacis Glabrae 12g, Herba Patriniae 11g, Cortex Phellodendri 12g, Radix Angelicae Sinensis 11g, Radix Stemonae 12g, Indigo Naturalis 11g, Radix Scutellariae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Radix Saposhnikoviae 13g, Flos Carthami 13g, Radix Rehmanniae 12g, Radix Sanguisorbae 13g, makes unguentum and uses, start the present invention to be decocted into medicinal liquid demibain in two days, once a day, the food such as avoid pungent food, scorching.Within 3 days, aftersensation pruritus is slowly no longer so hard to bear, and sleep did not yet think very and itched evening, no longer with hands, scratches brokenly, and after 7 days, skin lesion starts to take a turn for the better, and after 15 days, pruritus stops, then medication consolidation 1 month course for the treatment of, follows up a case by regular visits to without recurrence after half a year.

Claims (10)

1. an external preparation for the treatment of chronic eczema of scrotum, it is characterized in that, described external preparation comprises the crude drug of following weight portion: 10～20 parts of Galla Chinensiss, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Cortex Dictamnis, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Patriniae, 10～20 parts of Cortex Phellodendris, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Stemonae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Scutellariaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Saposhnikoviaes, 10～20 parts, Flos Carthami, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Radix Sanguisorbaes.

2. treat according to claim 1 the external preparation of chronic eczema of scrotum, it is characterized in that, in described external preparation, the parts by weight of various crude drug are: 10～15 parts of Galla Chinensiss, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Fructus Cnidiis, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Radix Arnebiae (Radix Lithospermi)s, 10～15 parts of Cortex Dictamnis, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Herba Patriniae, 10～15 parts of Cortex Phellodendris, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Stemonae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Scutellariaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Saposhnikoviaes, 10～20 parts, Flos Carthami, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Radix Sanguisorbaes.

3. treat according to claim 1 the external preparation of chronic eczema of scrotum, it is characterized in that, in described external preparation, the parts by weight of various crude drug are: 10～20 parts of Galla Chinensiss, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Cortex Dictamnis, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Patriniae, 10～20 parts of Cortex Phellodendris, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Stemonae, 10～15 parts of Indigo Naturaliss, 10～15 parts of Radix Scutellariaes, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Saposhnikoviaes, 10～15 parts, Flos Carthami, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Radix Sanguisorbaes.

4. as described in any one in claim 1～3, treat a preparation method for the external preparation of chronic eczema of scrotum, it is characterized in that, the preparation method that the dosage form of described medicine is unguentum comprises:

A, first crude drug to be cut into granule standby;

B, again the crude drug that is cut into granule is put into Oleum sesami, soak one day;

C, then with slow fire heating, when crude drug becomes when withered and yellow, the filtering of removing slag, calls in Cera Flava or Cera Flava, little fire is received cream;

D, by system ointment in cold water, place 24 hours, releasing fire-toxin.

5. as described in any one in claim 1～4, treat an external preparation for chronic eczema of scrotum, it is characterized in that, described external used medicine is gel, and its preparation method comprises the following steps:

A, first by crude drug ethanol extraction;

B, again raw material medicinal residues water after ethanol extraction is extracted;

C, by above-mentioned two kinds of extracting solution; Concentrated; Doped matrix is made gel.

6. according to the external preparation for the treatment of chronic eczema of scrotum described in any one in claim 1～5, it is characterized in that, in described step a, according to described parts by weight by crude drug soak with ethanol, rear 70～85 ℃ of heat are extracted, 10 times of amounts of the gross weight that ethanol consumption used is crude drug; Heating and refluxing extraction twice, each 1-2 hour, concentrated ethanol extract, is concentrated into relative density and is 1.08 concentrated solution, stand for standby use.

7. according to the external preparation for the treatment of chronic eczema of scrotum described in any one in claim 1～6, it is characterized in that, in described step b, the medicinal residues of the raw medicinal material of more above-mentioned ethanol extraction being crossed add the water that weight is 10 times of amounts of medicinal residues weight, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

8. treat according to claim 5 the external preparation of chronic eczema of scrotum, it is characterized in that, in described step c, above-mentioned two kinds of extracting solution are merged and filtered, 1.35 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.60, and the extractum that reduces pressure to obtain, stirs after being heated to 40～50 ℃, add again substrate, standing, be frozen into glue.

9. treat according to claim 8 the external preparation of chronic eczema of scrotum, it is characterized in that, described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

10. according to an external preparation for the treatment of chronic eczema of scrotum described in claim 1～9, it is characterized in that external used medicine dosage form: tincture, unguentum, powder, hip bath agent, lotion, gel and spray.