CN103721045A - Traditional Chinese medicine immunopotentiator for enhancing immune function of broiler chickens during growth - Google Patents

Abstract

The invention provides a traditional Chinese medicine immunopotentiator for enhancing an immune function of broiler chickens during growth. The immunopotentiator comprises crude medicines such as aleppo avens, panax japonicus, platycodon grandiflorum, pokeberry roots, fructus psoraleae, hawthorn fruits, Chinese yams, honeysuckle, sargentgloryvine stems, fructus cnidii, artemisia apiacea, bighead atractylodes rhizome, cinnamon, sealwort, wolfberries, radix glehniae, angelica sinensis, isatis roots, mistletoe, polygonum multiflorum, herba fibraureae recisae, thlaspi arvense, gynostemma pentaphylla and liquorice. The traditional Chinese medicine immunopotentiator has functions of increasing weight and promoting growth of the broiler chickens, has a function of promoting the immune function, can enhance the organism immunity, can improve the anti-bacterial and anti-virus capability and can improve the meat quality. The traditional Chinese medicine immunopotentiator plays an important role in adjusting immune organs, immune cells and the specific immune function of the broiler chickens and can effectively reduce drug residues and pathogenic microorganism residues of animal products.

Description

For improving broiler at the Chinese traditional immunopoteniators of the immunologic function of growth course

Technical field

The present invention relates to herbal medicine technical field, relate in particular to a kind of for improving the Chinese traditional immunopoteniators of broiler immune function in process of production.

Background technology

Broiler production is one of important industry of China's animal husbandry development, a mainstay of Ye Shi China livestock products foreign exchange earning.For a long time, China's broiler production is along controlling as main body in order to vaccine, environment, coordinate chemical medicine, the antibiotic veterinary system of preventing epidemic, consequently chemicals, hormone, antibiotic remains, cause animal to produce drug resistance, cause carcinogenic, teratogenesis and mutagenesis, and can be healthy by food chain harm humans, to human health and public health, form very large threat.

In addition, the developed countries such as China broiler product main exit America and Europe, Japan, Korea S, these countries have formulated strict standard to the microbiological contamination of import animal products, medicine are residual etc., and China's part commercial meat bird exists serious drug residue problem in producing always, thereby caused Carnis Gallus domesticus to export difficult present situation, restricted the healthy and stable development of Chicken industry, especially, after accession to WTO, foreign government is often refused the broiler product of import China as excuse.

Because long-term extensive existence and the various stressors of Drug abuse, irrational vaccination, immunosuppressive disease in a large number cause meat chicken production performance and immunologic function degression, therefore, how to improve meat chicken production performance and enhancing human body immunity function is the focus of animal and veterinary focus of attention always.

Along with improving constantly of living standards of the people, people's self health consciousness strengthens gradually, Chinese herbal medicine can not only improve fertility performance and the feed conversion rate of broiler, effectively improve meat flavor, and many Chinese herbal medicine have immunological enhancement, can improve the non-specific and specific immune function of body, the resistance of enhancing body, play good growth promotion and disease resisting effect, the Chinese herbal medicine of usining is produced green non-pollution broiler product as immunostimulant, is more and more subject to social extensive concern.Chinese herbal feed additive is in modernization, intensive farm are produced, the product that performance Chinese herbal medicine disease-prevention health, the superiority development such as promote to grow, have no drug resistance get up, have natural sex, multifunctionality, toxic and side effects little, be difficult in meat, producing the advantages such as hazard residue and day by day favored.

Motherland's medical science is thought " healthy energy deposit in, heresy can not be done ", " institute of heresy gathers, and its gas must be empty ".This viewpoint has affirmed that body healthy energy (endogenous cause of ill) has conclusive effect to whether falling ill.The present invention's Chinese traditional immunopoteniators used is exactly this viewpoint based on Chinese medicine, from safeguarding, consolidates that healthy energy in body, improvement and enhancing body resistance set about forming.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of novel for improving the Chinese traditional immunopoteniators of feeding of broiler growth course immune function, it has the somatotrophic effect of weightening finish to broiler, immunologic function is had to facilitation, can enhancing human body immunity power, improve anti-bacteria and anti-virus ability, improve meat.This Chinese traditional immunopoteniators not only has important regulating action to broiler immune organ, immunocyte and specific immune function, but also it is residual effectively to reduce drug residue and the pathogenic microorganism of animal product.

In order to solve the problems of the technologies described above, the invention provides a kind ofly for improving broiler at the Chinese traditional immunopoteniators of the immunologic function of growth course, its crude drug comprises Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Herba Thlaspis, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.

Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 45～55 weight portions, Rhizoma Panacis Japonici 40～50 weight portions, Radix Platycodonis 20～30 weight portions, Radix Phytolaccae 25～35 weight portions, Fructus Psoraleae 50～60 weight portions, Fructus Crataegi 20～30 weight portions, Rhizoma Dioscoreae 70～80 weight portions, Flos Lonicerae 25～35 weight portions, Caulis Sargentodoxae 20～30 weight portions, Fructus Cnidii 35～45 weight portions, Herba Artemisiae Annuae 15～25 weight portions, the Rhizoma Atractylodis Macrocephalae 40～50 weight portions, Cortex Cinnamomi 20～30 weight portions, Rhizoma Polygonati 45～55 weight portions, Fructus Lycii 35～45 weight portions, Radix Glehniae 40～50 weight portions, Radix Angelicae Sinensis 30～40 weight portions, Radix Isatidis 20～30 weight portions, Herba Visci 35～45 weight portions, Radix Polygoni Multiflori 30～40 weight portions, Caulis Fibraureae 20～30 weight portions, Herba Thlaspis 15～25 weight portions, Herb Gynostemmae Pentaphylli 30～40 weight portions and Radix Glycyrrhizae 25～35 weight portions.

Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 50 weight portions, Rhizoma Panacis Japonici 45 weight portions, Radix Platycodonis 25 weight portions, Radix Phytolaccae 30 weight portions, Fructus Psoraleae 55 weight portions, Fructus Crataegi 25 weight portions, Rhizoma Dioscoreae 75 weight portions, Flos Lonicerae 30 weight portions, Caulis Sargentodoxae 25 weight portions, Fructus Cnidii 40 weight portions, Herba Artemisiae Annuae 20 weight portions, the Rhizoma Atractylodis Macrocephalae 45 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Polygonati 50 weight portions, Fructus Lycii 40 weight portions, Radix Glehniae 45 weight portions, Radix Angelicae Sinensis 35 weight portions, Radix Isatidis 25 weight portions, Herba Visci 40 weight portions, Radix Polygoni Multiflori 35 weight portions, Caulis Fibraureae 25 weight portions, Herba Thlaspis 20 weight portions, Herb Gynostemmae Pentaphylli 35 weight portions and Radix Glycyrrhizae 30 weight portions.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, and the dosage form of described Chinese traditional immunopoteniators is injection, and described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, component under She is mixed in proportion, get 100g mixture, the water that adds 500g～800g, boil 3～4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boil 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the first step to obtain, being stirred to powder dissolves completely, concentrated, remove portion water, volume to solution is 100mL, cold preservation at the temperature of 0 ℃, filter, filtrate adds 10% activated carbon decolorizing, Ex-all active carbon, with 10% sodium hydroxide solution, regulate pH value to 6.5～7.5, embedding, sterilizing, obtain injection.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, and the dosage form of described Chinese traditional immunopoteniators is decoction liquor, and described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the first step to obtain, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, described Chinese traditional immunopoteniators be feed additive powder, described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated except anhydrating, obtain the second dry powder, the first powder is mixed with the second powder, obtain feed additive powder.

It is a kind of for improving broiler at the Chinese medicine feed additive of the immunologic function of growth course that the present invention also provides, and the crude drug of described Chinese medicine feed additive comprises Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Herba Thlaspis, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.

It is a kind of for feedstuff that the present invention also provides, and it comprises main feed and above-mentioned feed additive, and with respect to the main feed of 100 weight portions, the addition of described feed additive is 15 weight portion～18 weight portions.

Wherein, described main feed is Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.

The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:

The first step, prepares described feed additive powder according to the method described above;

Second step, sneaks into above-mentioned feed additive powder in main feed in proportion.

Beneficial effect of the present invention:

Chinese traditional immunopoteniators provided by the invention has the somatotrophic effect of weightening finish to broiler, and immunologic function is had to facilitation, can enhancing human body immunity power, improve anti-bacteria and anti-virus ability, and improve meat.This Chinese traditional immunopoteniators not only has important regulating action to broiler immune organ, immunocyte and specific immune function, but also it is residual effectively to reduce drug residue and the pathogenic microorganism of animal product.

The specific embodiment

Chinese traditional immunopoteniators is the natural Chinese medicine that utilizes China's abundant, according to modern Chinese veterinarian's pharmacology opinion scientific composition, for improving the Chinese medicine preparation of the immunologic function of body.Chinese traditional immunopoteniators is specially at the mechanism of action improving aspect the immunologic function of broiler: 1. Promote immunity allelotaxis: increase weight and the index of the immune organs such as spleen gland, spleen and bud fabricius bursa, antagonism immunologic injury is as the atrophy of immune organ due to cycli phosphate amine, lonizing radiation etc.; 2. strengthen cellular immune function: activation and the thin marrow function of enhancing immunity, comprise T, bone-marrow-derived lymphocyte, the burnt born of the same parents of N, mononuclear phagocyte and leukocyte etc.As promote the synthetic of lymphocyte DNA, and improving lymhocyte transformation rate, T lymphocyte percentage, activating macrophage function, strengthens the effect that it engulfs, processes, transmits antigen; 3. strengthen humoral immunization: the synthetic and secretion of enhancing antibody, extends antibody life period, the immunogenicity of enhancement antigen material and stability; 4. promote cytokine secretion and activity: as promoted secretion and the activity of interleukin, interferon, tumor necrosis factor etc.; 5. the immune infringement such as antagonism lonizing radiation, chemicals, cancerous cell, recovers spleen and lymphoid function etc.

The immunocompetence of human body body is body defence and removes pathogenic microorganism and harmful substance, to keep and to recover the ability of normal physiological effect.The eliminating evil class medicine of the strengthening by means of tonics class medicine of Chinese herbal medicine and part has low immunoreation facilitation, can improve body immune system function.In natural plants, be rich in bioactive substance, the ability of scalable internal body resist the disease, improves body non-specific immunity, strengthens on the whole the diseases prevention power of body.

Phagocyte has the function that foreign body is engulfed and digested, and in body inherent immunity, plays an important role, and Chinese medicine also has the effect that improves phagocyte phagocytic function.Erythrocyte has the effect of removing immune complex, promoting to engulf, identify antigen, submission antigen, immunomodulating and the immunity of participation anti-tumor in vivo, can strengthen erythrocytic immunologic function.

The immunoregulation effect of Chinese medicine is not the immunological effect of simple function, but the function system being associated with Neuroendocrine regulation (MM) network closely.It both can directly affect the substance metabolism of immunocyte, can induce again immune cell to produce relevant cytokine (as: interleukin, interferon etc.); Both humoral immunization that can enhancing body, cellular immunization that again can enhancing body; Both can strengthen the immunologic function of normal body, the immunologic function of the abnormal body of scalable again, can regulate from immune organ-cell-molecule and even gene transcription level immune state and the function of body.

Chinese veterinarian thinks, the process of any disease is all the process of healthy energy and pathogen contradiction both sides struggle.Therefore, the basic goal for the treatment of is wanted reinforcing body resistance exactly, eliminating pathogens, and the relative equilibrium of recovery body negative and positive, makes disease processes transform to recovery from illness direction.So-called righting, is used the square medicine of tonification healthy energy exactly, to improve the resistivity of body, reaches eliminating evil gas, defeats disease, restorative object.Chinese medicine immunopotentiating agent not only has the fertility performance that improves broiler, increase weight and the index of immune organ, improve the antibody titer of vaccine, strengthen the various immunologic functions of chicken, can also complement activation, promote cytokine to generate, strengthen hematid immunity function etc., immune system is brought into play to many-sided regulating action, the present invention be exactly propose on this basis a kind of for improving broiler at the Chinese traditional immunopoteniators of the immunologic function of growth course, its crude drug comprises Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Herba Thlaspis, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.

In side, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Cnidii, Rhizoma Polygonati, Fructus Lycii has obvious facilitation to broiler immunologic function, they can activate body immune system, improve quantity and the effect of immunologically competent cell, increase the growth of immunocyte and synthesizing of antibody, thereby improve the premunition of body, maintain organismic internal environment balance, platycodon root polysaccharide in Radix Platycodonis can significantly improve the generation of polyclonal antibody IgM and the propagation of B cell, Radix Phytolaccae can significantly improve chicken T lymhocyte transformation rate, can significantly improve the non-specific cell immunologic function of its body, Fructus Psoraleae can significantly improve erythrocyte C ₃the promotion rate of b receptor garland, significantly reduces erythrocyte C ₃the suppression ratio of b receptor garland, the remarkable or utmost point significantly improves erythrocyte C ₃b receptor rosette rate, the utmost point significantly improves lymhocyte transformation rate, can strengthen the immunocompetence of heat stress broiler, and Fructus Crataegi can increase the secretion of digestive enzyme in stomach, facilitating digestion, and contain lipase, can strengthen gastric lipase, the active ， Herba Thlaspis of protease has stronger antibacterial action to dysentery bacterium, to bacillus pyocyaneus, gold-coloured staphylococci, escherichia coli, Bacillus proteus, anthrax bacillus, streptococcus, Bacillus typhi etc. all have antibacterial action, Herba Visci, Rhizoma Dioscoreae energy promotion health carcass lymhocyte transformation rate, increases the quantity of T cell, thereby improve the huge ability of biting, improves immunity of organisms, Flos Lonicerae, Caulis Fibraureae has broad-spectrum antiseptic, antiviral, antitumor, immunostimulant and antipyretic and anti-inflammatory, the multiple pharmacological effect such as function of gallbladder promoting profit liver, Caulis Sargentodoxae can increase the quantity of blood middle leukocytes, improves the phagocytic function of chicken abdominal cavity mononuclear phagocyte system, and Herba Artemisiae Annuae can resisting pathogenic microbes, antiendotoxin, antiinflammatory, antipyretic, analgesia, immunomodulating, improve hemopoietic function, improve immunity of organisms, the Rhizoma Atractylodis Macrocephalae can obviously increase serum IgG, improve body resistance against diseases, Cortex Cinnamomi warming spleen and stomach for dispelling cold, recuperating depleted YANG and rescuing the patient from collapse, Radix Glehniae can extend the time that antibody exists in chicken body, Radix Angelicae Sinensis has anti-platelet aggregation and anti thrombotic action, can promote hemoglobin and erythrocytic generation, and specificity and the non-specific immunity of energy enhancing body, Radix Isatidis has antiinflammatory, antiviral, antipyretic and strengthen immunity and wait effect, Radix Polygoni Multiflori is improved body's immunity, anti-stress effect and improve the several functions such as Nutrition and Metabolism, Herb Gynostemmae Pentaphylli can be improved serum hemolysin content, illustrate that it has facilitation to humoral immunization, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines are coordinated, 5 use each other, thereby renal function is coordinated, and vital essence is full, makes taste essence of water and grain be able to timely running, to meet body nutritional need, full side fills blood, liver and kidney tonifying, strengthening the spleen and stomach has played integrally-regulated effect to broiler, to Abwehrkraft des Koepers, adaptive faculty and immunity have good adjusting effect, and have class gonadotropic Effect, thereby organism metabolism has been produced to good comprehensive adjustment effect.

Further, described Chinese traditional immunopoteniators only consists of above-mentioned raw materials medicine.

In described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively: Radix seu Herba Gei aleppici 45～55 weight portions, Rhizoma Panacis Japonici 40～50 weight portions, Radix Platycodonis 20～30 weight portions, Radix Phytolaccae 25～35 weight portions, Fructus Psoraleae 50～60 weight portions, Fructus Crataegi 20～30 weight portions, Rhizoma Dioscoreae 70～80 weight portions, Flos Lonicerae 25～35 weight portions, Caulis Sargentodoxae 20～30 weight portions, Fructus Cnidii 35～45 weight portions, Herba Artemisiae Annuae 15～25 weight portions, the Rhizoma Atractylodis Macrocephalae 40～50 weight portions, Cortex Cinnamomi 20～30 weight portions, Rhizoma Polygonati 45～55 weight portions, Fructus Lycii 35～45 weight portions, Radix Glehniae 40～50 weight portions, Radix Angelicae Sinensis 30～40 weight portions, Radix Isatidis 20～30 weight portions, Herba Visci 35～45 weight portions, Radix Polygoni Multiflori 30～40 weight portions, Caulis Fibraureae 20～30 weight portions, Herba Thlaspis 15～25 weight portions, Herb Gynostemmae Pentaphylli 30～40 weight portions and Radix Glycyrrhizae 25～35 weight portions.

In described Chinese traditional immunopoteniators, the weight portion of each crude drug is further preferably respectively: Radix seu Herba Gei aleppici 48～52 weight portions, Rhizoma Panacis Japonici 43～47 weight portions, Radix Platycodonis 23～27 weight portions, Radix Phytolaccae 28～32 weight portions, Fructus Psoraleae 53～57 weight portions, Fructus Crataegi 23～27 weight portions, Rhizoma Dioscoreae 73～77 weight portions, Flos Lonicerae 28～32 weight portions, Caulis Sargentodoxae 23～27 weight portions, Fructus Cnidii 38～42 weight portions, Herba Artemisiae Annuae 18～22 weight portions, the Rhizoma Atractylodis Macrocephalae 43～47 weight portions, Cortex Cinnamomi 23～27 weight portions, Rhizoma Polygonati 48～52 weight portions, Fructus Lycii 38～42 weight portions, Radix Glehniae 43～47 weight portions, Radix Angelicae Sinensis 33～37 weight portions, Radix Isatidis 23～27 weight portions, Herba Visci 38～42 weight portions, Radix Polygoni Multiflori 33～37 weight portions, Caulis Fibraureae 23～27 weight portions, Herba Thlaspis 18～22 weight portions, Herb Gynostemmae Pentaphylli 33～37 weight portions and Radix Glycyrrhizae 28～32 weight portions.

In described Chinese traditional immunopoteniators, the weight portion of each crude drug is most preferably respectively: Radix seu Herba Gei aleppici 50 weight portions, Rhizoma Panacis Japonici 45 weight portions, Radix Platycodonis 25 weight portions, Radix Phytolaccae 30 weight portions, Fructus Psoraleae 55 weight portions, Fructus Crataegi 25 weight portions, Rhizoma Dioscoreae 75 weight portions, Flos Lonicerae 30 weight portions, Caulis Sargentodoxae 25 weight portions, Fructus Cnidii 40 weight portions, Herba Artemisiae Annuae 20 weight portions, the Rhizoma Atractylodis Macrocephalae 45 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Polygonati 50 weight portions, Fructus Lycii 40 weight portions, Radix Glehniae 45 weight portions, Radix Angelicae Sinensis 35 weight portions, Radix Isatidis 25 weight portions, Herba Visci 40 weight portions, Radix Polygoni Multiflori 35 weight portions, Caulis Fibraureae 25 weight portions, Herba Thlaspis 20 weight portions, Herb Gynostemmae Pentaphylli 35 weight portions and Radix Glycyrrhizae 30 weight portions.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, and the dosage form of described Chinese traditional immunopoteniators is injection, and described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, component under She is mixed in proportion, get 100g mixture, the water that adds 500g～800g, boil 3～4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boil 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the 100g first step to obtain, being stirred to powder dissolves completely, concentrated, remove portion water, volume to solution is 100mL, cold preservation at the temperature of 0 ℃, filter, filtrate adds 10% activated carbon decolorizing, Ex-all active carbon, with 10% sodium hydroxide solution, regulate pH value to 6.5～7.5, embedding, sterilizing, obtain injection.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, and the dosage form of described Chinese traditional immunopoteniators is decoction liquor, and described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the first step to obtain, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor.

The present invention also provides the preparation method of above-mentioned Chinese traditional immunopoteniators, described Chinese traditional immunopoteniators be feed additive powder, described method comprises:

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated except anhydrating, obtain the second dry powder, the first powder is mixed with the second powder, obtain feed additive powder.

It is a kind of for feedstuff that the present invention also provides, and it comprises main feed and above-mentioned feed additive powder, and with respect to the main feed of 100 weight portions, the addition of described feed additive powder is 15 weight portion～18 weight portions.

Described main feed can be the conventional feed of the eaten by broilers such as Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.

The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:

The first step, prepares described feed additive powder according to the method described above;

Second step, sneaks into above-mentioned feed additive powder in main feed in proportion.

The pharmacology of each crude drug is as follows:

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is flat, returns liver, spleen, lung meridian, has analgesia, blood pressure lowering, regulating menstruation, the effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison, the cards such as traumatic injury are controlled in external.

Rhizoma Panacis Japonici: latin name Panacis Japonici Rhizoma, sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, there is strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm, cures mainly weakness after being ill, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.

Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enters lung meridian, has the effect of expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, cures mainly the cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Radix Phytolaccae: latin name Phytolaccae Radix, bitter in the mouth, cold in nature, return spleen, urinary bladder channel, have logical two just, the effect of removing water retention by purgation eliminating stagnation, cures mainly edema, distension, beriberi, sore throat, carbuncle, the cards such as malignant boil.

Fructus Psoraleae: latin name Psoraleae Fructus, acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, there is kidney invigorating and YANG supporting, warming spleen and stopping diarrha effect, is mainly used in decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea; It is cold that insufficiency of kidney-YANG, spleen soil lose using warming therapy stomachache limb, the cards such as Diarrhoea.

Fructus Crataegi: latin name Crataegi Fructus, sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. are had to obvious inhibitory action.

Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Flos Lonicerae: sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, there is the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and has broad-spectrum antibacterial action.

Caulis Sargentodoxae: latin name Sargentodoxae Caulis, bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.

Fructus Cnidii: latin name Cnidii Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, there is the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male causing for kidney yang deficiency, woman's cold womb are infertile, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.

Herba Artemisiae Annuae: latin name Artemisiae Annuae Herba, bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, have deficiency-heat clearly thoroughly, removing heat from blood is except steaming, and except steaming, the effect of preventing the attack (or recurrence) of malaria, cures mainly pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, the cards such as jaundice due to damp-heat.

The Rhizoma Atractylodis Macrocephalae: latin name Attractylodis Macrocephalae Rhizoma, sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had to regulating action.

Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet, returns kidney, spleen, the heart, Liver Channel, has the fire of benefit supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, the cards such as heat in the upper and cold in the lower.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood.

Radix Glehniae: latin name Glehniae Radix, sweet in the mouth, micro-hardship, cold nature, there is nourishing YIN and clearing away lung-heat, the effect of reinforcing stomach reg fluid, for cards such as lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound are thirsty, Rhizoma Polygonati and Radix Glehniae are combined with and can be used for treating that deficiency of YIN of the spleen and stomach, hunger but having no desire to eat, gastral cavity abdomen do not relax, dryness of the mouth and throat, the diseases such as red tongue with a little fluid.

Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, enter liver, the heart, spleen channel, having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, the relieving constipation of profit soup, for cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Isatidis: latin name Isatidis Radix, bitter in the mouth, cold in nature, enters the heart, liver, gallbladder, stomach warp, has the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, is used for the treatment of maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat the cards such as epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.

Herba Visci: bitter in the mouth, sweet, property is flat.Return liver, kidney channel, have relaxing muscles and tendons and activating QI and blood in the collateral, the effect of promoting blood circulation to remove blood stasis, cures mainly frequent fetal movement, vaginal bleeding during pregnancy hematochezia, bones and muscles pain, limbs contracture, aching pain in waist and back, the cards such as traumatic injury.

Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, slightly warm in nature, returns liver, kidney channel, has the effect of nourishing the blood and yin, loosening bowel to relieve constipation, cures mainly blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; The cards such as hemorrhoid.

Caulis Fibraureae: bitter in the mouth, cold in nature, GUIXIN, Liver Channel, have the effect of heat-clearing and toxic substances removing, pathogenic fire purging relieving constipation, cures mainly dominance of heat in the interior, constipation, dysentery, laryngopharynx swelling and pain, conjunctival congestion is red and swollen, the cards such as carbuncle sore tumefacting virus.

Herba Thlaspis: latin name Thlaspi Herba, acrid in the mouth, cold nature, returns liver, stomach, large intestine channel, has liver heat removing and eyesight improving, and middle dampness removing, the effect of removing toxic substances and promoting subsidence of swelling, for conjunctival congestion and swelling pain, abdominal distention, hypochondriac pain, acute appendicitis, edema, is with inferior card.

Herb Gynostemmae Pentaphylli: another name Herba Gynostemmatis, Pentapanax, gynostemma pentaphyllum makino, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, the sweet bitter edible plant are climing, southern Radix Ginseng, cold in nature, bitter in the mouth, returns lung, spleen, kidney channel, has QI invigorating, calm the nerves, the effect of blood pressure lowering, for deficiency of vital energy and physically weak, weak breath is weak; Vexed insomnia; Hypertension, Light-headedness; Viral hepatitis; Digestive tract tumor; The cards such as chronic bronchitis, through modern medicine study, find, the main effective ingredient of Herb Gynostemmae Pentaphylli is polysaccharide, flavonoid, saponins and microelement kind, and its effect is mainly to promote body fat class substance metabolism, nutrition human body cell, has good detoxicating, relieving inflammation effect simultaneously.

Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

The preparation of embodiment 1 decoction liquor 1

By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g, Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g, with Herba Thlaspis 20g mix homogeneously is got mixture 100g and packed in percolator, adds the Chinese liquor 700g of 55 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 700mL, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder, by Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, Cortex Cinnamomi 25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mixes, and gets 100g mixture, adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, add the dry powder obtaining above, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor 1.

Embodiment 2 toxicological experiments

Acute toxicity testing

Select 20 of Kunming mouses, female half and half, body weight (20+2) g, is provided by Qingdao City's Experimental Animal Center, and the decoction liquor of embodiment 1 preparation is gavaged to mice, through preliminary experiment, fails to detect the LD of oral administration ₅₀, therefore survey its maximum tolerated dose, administration volume with 1.4ml/10g body weight, gavage 2 times/d, interval 6h, give observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, all animals is processed, dissect, each main organs lesion tissue situation of perusal, gavage for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, observe 7d animal dead, gross necropsy has no the obviously abnormal of main organs tissue, therefore, the maximum dosage-feeding of Chinese medicine granules is >140g crude drug/kg, this dosage is equivalent to 70 times of maximum oral dose 2g crude drug/kg clinical adult (by 60kg) every day.

Long term toxicity test

Select 40 male SD rats, weight (180 ± 20) g, by Qingdao City's Experimental Animal Center, provided, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, Chinese drug-treated group, by the decoction liquor 1 of embodiment 1 preparation, gavages rat, and the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, observe rat general state, sign, food ration, drinking-water and feces situation every day before administration and during administration.During administration 90d, after last administration 24h, each group extracts 6, male and female half and half; During 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, each group of 30d extracts 6, male and female half and half, with urethane, anaesthetize, from abdominal aortic, get blood, each group is all killed and is got animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.

On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, it is dead that animal has no, naked eyes have no obvious pathological changes, each organizes the inspection of rat peripheral hemogram all in normal range, and the raw tea index of blood is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is compared and be there is no significant difference with blank group.

From embodiment 2, can find out, the clinical use of Chinese medicine composition of the present invention is safe.

The preparation of embodiment 3 decoction liquor 2

By Radix seu Herba Gei aleppici 45g, Rhizoma Panacis Japonici 40g, Fructus Psoraleae 50g, Rhizoma Atractylodis Macrocephalae 40g, Rhizoma Polygonati 45g, Radix Glehniae 40g, Fructus Lycii 35g, Herba Visci 35g, Herb Gynostemmae Pentaphylli 30g, with Herba Thlaspis 15g mix homogeneously is got mixture 100g and packed in percolator, adds the Chinese liquor 700g of 55 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 700mL, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder, by Radix Platycodonis 20g, Radix Phytolaccae 25g, Fructus Crataegi 20g, Rhizoma Dioscoreae 70g, Flos Lonicerae 25g, Caulis Sargentodoxae 20g, Fructus Cnidii 35g, Herba Artemisiae Annuae 15g, Cortex Cinnamomi 20g, Radix Angelicae Sinensis 30g, Radix Isatidis 20g, Radix Polygoni Multiflori 30g, Caulis Fibraureae 20g, Radix Glycyrrhizae 25g mixes, and gets 100g mixture, adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, add the dry powder obtaining above, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor 2.

The preparation of embodiment 4 decoction liquor 3

By Radix seu Herba Gei aleppici 55g, Rhizoma Panacis Japonici 50g, Fructus Psoraleae 60g, Rhizoma Atractylodis Macrocephalae 50g, Rhizoma Polygonati 55g, Radix Glehniae 50g, Fructus Lycii 45g, Herba Visci 45g, Herb Gynostemmae Pentaphylli 40g, with Herba Thlaspis 25g mix homogeneously is got mixture 100g and packed in percolator, adds the Chinese liquor 700g of 55 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 700mL, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder, by Radix Platycodonis 30g, Radix Phytolaccae 35g, Fructus Crataegi 30g, Rhizoma Dioscoreae 80g, Flos Lonicerae 35g, Caulis Sargentodoxae 30g, Fructus Cnidii 45g, Herba Artemisiae Annuae 25g, Cortex Cinnamomi 30g, Radix Angelicae Sinensis 40g, Radix Isatidis 30g, Radix Polygoni Multiflori 40g, Caulis Fibraureae 30g, Radix Glycyrrhizae 35g mixes, and gets 100g mixture, adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, add the dry powder obtaining above, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor 3.

The preparation of embodiment 5 injection 1

By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g, Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g, with Herba Thlaspis 20g mix homogeneously is got mixture 100g and packed in percolator, adds the Chinese liquor 700g of 55 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 700mL, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder, by Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, Cortex Cinnamomi 25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mixes, and gets 100g mixture, adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, add the dry powder obtaining above, being stirred to powder dissolves completely, concentrated, remove portion water, to the volume of solution be 100mL, cold preservation at the temperature of 0 ℃, filter, filtrate adds 10% activated carbon decolorizing, Ex-all active carbon, with 10% sodium hydroxide solution, regulate pH value to 7, embedding, sterilizing, obtains injection 1.

The preparation of embodiment 6 Chinese medicine composition feed additive powder

By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g, Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g, with Herba Thlaspis 20g mix homogeneously is got mixture 100g and packed in percolator, adds the Chinese liquor 700g of 55 ℃, under the condition of 30 ℃, soak 25 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, the speed of oozing is 3mL per minute, collects drip, obtains the percolate of 700mL, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dry powder, by Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, Cortex Cinnamomi 25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mixes, and gets 100g mixture, adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated except anhydrating, obtain the second dry powder, the first powder is mixed with the second powder, obtain feed additive powder.

The concrete preparation of embodiment 7 feedstuffs

The feed additive powder 160g of embodiment 5 preparations is sneaked in the Semen Tritici aestivi of 1kg, obtain feedstuff.

Embodiment 8 raising data

Laboratory animal

260 of healthy broiler chicks, 1 age in days, purchased from chicken farm, Qingdao, average weight 68.5g, is divided into 2 groups: medium-height grass group and matched group.

Feeding method

The decoction liquor 1 of the Chinese drug-treated group gavage every day embodiment of the present invention 1 preparation, gavages 3 every day, each 30mL, and matched group adds clean drinking-water.Two groups are all carried out conventional feeding and management and daily immunity.

Test method

Weightening finish

Each group is all attenuated vaccine in 10 age in days inoculation newcastle VI, and purchased from Guangdong Dahuanong Animal Healthcare Product Ltd, in 20 and 40 ages in days, each gets 10 at random, weighs respectively.

The detection of part normal blood index

The indexs such as RBC (erythrocyte), WBC (leukocyte), LYM (lymphocyte), HGB (content of hemoglobin) are all used U.S. QBC-R routine blood test analyzer to measure.Application Excel software carries out t check analysis to above data.

The detection of immunologic function

Detect NDV HI antibody, the immune organ of weighing (spleen, fabricius bursa and thymus) also calculates Immune Organs Index as follows: Immune Organs Index=immune organ weight in wet base/body weight * 100.Pass through C ₃b receptor rosette formation test, detects erythrocytic adhesion.

NDV antibody titer

Choose respectively 10 for every group, vein or heart blood sampling under the wing, separation of serum, detects and respectively organizes NDV serum antibody titer with hemagglutination inhibition test (HI), calculates and respectively organizes average antibody titre.

Result

The variation of two groups of broiler weights, the results are shown in Table 1.

The variation (g) of table 1 liang group broiler weight

As can be seen from Table 1, compare with matched group, adopt Chinese traditional immunopoteniators decoction liquor of the present invention can significantly improve the growth body weight of broiler chicks, P<0.05, has comparability.

The variation of NDV antibody titer, the results are shown in Table 2.

A table 2 liang group broiler chicks serum N DV antibody titer changes

As can be seen from Table 2, adopt Chinese traditional immunopoteniators of the present invention, in feeding process, the serum N DV antibody titer of broiler chicks increases significantly compared with matched group, and P<0.05, has comparability.

The variation of two groups of broiler chicks erythrocyte receptor rosette rate, the results are shown in Table 3.

The variation (%) of table 3 liang group broiler chicks erythrocyte receptor rosette rate

As can be seen from Table 3, with respect to matched group, adopt Chinese traditional immunopoteniators of the present invention, in feeding process, it is more that the erythrocyte receptor rosette rate of broiler chicks increases, P<0.05, has comparability, proves that Chinese traditional immunopoteniators of the present invention can strengthen erythrocytic immunologic function.

The variation of Immune Organs Index, the results are shown in Table 4.

The variation of the Immune Organs Index of table 4 liang group broiler chicks

As can be seen from Table 4, adopt Chinese traditional immunopoteniators of the present invention can significantly increase index and spleen index, fabricius bursa exponential sum thymus index.

The variation of two groups of broiler chicks blood routine biochemical indicators, the results are shown in Table 5 and table 6.

The variation of table 5 liang group broiler chicks lymphocyte number and hemoglobin number

The variation of table 6 liang group broiler chicks RBC number and leukocyte count

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. for improving broiler at a Chinese traditional immunopoteniators for the immunologic function of growth course, it is characterized in that: the crude drug of described Chinese traditional immunopoteniators comprises Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Herba Thlaspis, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.

2. Chinese traditional immunopoteniators as claimed in claim 1, it is characterized in that: in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 45～55 weight portions, Rhizoma Panacis Japonici 40～50 weight portions, Radix Platycodonis 20～30 weight portions, Radix Phytolaccae 25～35 weight portions, Fructus Psoraleae 50～60 weight portions, Fructus Crataegi 20～30 weight portions, Rhizoma Dioscoreae 70～80 weight portions, Flos Lonicerae 25～35 weight portions, Caulis Sargentodoxae 20～30 weight portions, Fructus Cnidii 35～45 weight portions, Herba Artemisiae Annuae 15～25 weight portions, the Rhizoma Atractylodis Macrocephalae 40～50 weight portions, Cortex Cinnamomi 20～30 weight portions, Rhizoma Polygonati 45～55 weight portions, Fructus Lycii 35～45 weight portions, Radix Glehniae 40～50 weight portions, Radix Angelicae Sinensis 30～40 weight portions, Radix Isatidis 20～30 weight portions, Herba Visci 35～45 weight portions, Radix Polygoni Multiflori 30～40 weight portions, Caulis Fibraureae 20～30 weight portions, Herba Thlaspis 15～25 weight portions, Herb Gynostemmae Pentaphylli 30～40 weight portions and Radix Glycyrrhizae 25～35 weight portions.

3. Chinese traditional immunopoteniators as claimed in claim 1 or 2, it is characterized in that: in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 50 weight portions, Rhizoma Panacis Japonici 45 weight portions, Radix Platycodonis 25 weight portions, Radix Phytolaccae 30 weight portions, Fructus Psoraleae 55 weight portions, Fructus Crataegi 25 weight portions, Rhizoma Dioscoreae 75 weight portions, Flos Lonicerae 30 weight portions, Caulis Sargentodoxae 25 weight portions, Fructus Cnidii 40 weight portions, Herba Artemisiae Annuae 20 weight portions, the Rhizoma Atractylodis Macrocephalae 45 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Polygonati 50 weight portions, Fructus Lycii 40 weight portions, Radix Glehniae 45 weight portions, Radix Angelicae Sinensis 35 weight portions, Radix Isatidis 25 weight portions, Herba Visci 40 weight portions, Radix Polygoni Multiflori 35 weight portions, Caulis Fibraureae 25 weight portions, Herba Thlaspis 20 weight portions, Herb Gynostemmae Pentaphylli 35 weight portions and Radix Glycyrrhizae 30 weight portions.

4. the preparation method of the Chinese traditional immunopoteniators described in claims 1 to 3, is characterized in that: the dosage form of described Chinese traditional immunopoteniators is injection, and described method comprises,

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, component under She is mixed in proportion, get 100g mixture, the water that adds 500g～800g, boil 3～4 hours, filter, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boil 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the first step to obtain, being stirred to powder dissolves completely, concentrated, remove portion water, volume to solution is 100mL, cold preservation at the temperature of 0 ℃, filter, filtrate adds 10% activated carbon decolorizing, Ex-all active carbon, with 10% sodium hydroxide solution, regulate pH value to 6.5～7.5, embedding, sterilizing, obtain injection.

5. the preparation method of the Chinese traditional immunopoteniators described in claims 1 to 3, is characterized in that: the dosage form of described Chinese traditional immunopoteniators is decoction liquor, and described method comprises,

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the dry powder that adds the first step to obtain, be stirred to powder and dissolve completely, concentrated crude drug concentration is 1g/mL, obtains decoction liquor.

6. the preparation method of the Chinese traditional immunopoteniators described in claims 1 to 3, is characterized in that: described Chinese traditional immunopoteniators be feed additive powder, described method comprises,

The first step, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli He Herba Thlaspis are mixed in proportion, getting mixture 100g packs in percolator, Chinese liquor 600g～the 800g that adds 50 ℃～55 ℃, under the condition of 25 ℃～35 ℃, soak 20 hours～30 hours, regulate percolator valve, Chinese liquor medicinal liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtain the percolate of 700mL～1L, concentrated, remove Chinese liquor, dry, pulverize, obtain the first dry powder;

Second step, is mixed in proportion component under She, gets 100g mixture, the water that adds 500g～800g, boils 3～4 hours, filters, obtain the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated except anhydrating, obtain the second dry powder, the first powder is mixed with the second powder, obtain feed additive powder.

7. for improving broiler at a Chinese medicine feed additive for the immunologic function of growth course, it is characterized in that: the crude drug of described Chinese medicine feed additive comprises Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Herba Thlaspis, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.

8. for a feedstuff, it is characterized in that: comprise that main feed and claim states the feed additive described in 7, with respect to the main feed of 100 weight portions, the addition of described feed additive is 15 weight portion～18 weight portions.

9. feedstuff as claimed in claim 8, is characterized in that: described main feed is Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.

10. the preparation method of feedstuff described in claim 8 or 9, is characterized in that, comprising:

The first step, prepares described feed additive powder according to the method described above;

Second step, sneaks into above-mentioned feed additive powder in main feed in proportion.