CN103705751B - Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof, Chinese medicine composition comprises following raw medicinal material: Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.The invention has the beneficial effects as follows: Chinese medicine composition of the present invention is based on dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving, and it is best that treatment lumbago due to pathogenic wind-dampness has curative effect, focus of going directly, the course for the treatment of is shorter, and medicament is easy to manufacture, and toxic and side effects is little, convenient drug administration, not easily recurs and advantage with low cost more.

Description

Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof

Technical field

The present invention relates to the medicine being used for the treatment of lumbago due to pathogenic wind-dampness, particularly a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof.

Background technology

Lumbago due to pathogenic wind-dampness is because waist suffers the invasion and attack of wind-cold damp pathogen, causes blood vessels numbness to hinder, and motion is smooth, thus causes the clinical symptoms such as waist swelling and pain, apathy.Modern medicine thinks the generation of primary disease, with tired, catch cold relevant with humidity, as occupied wetland for a long time, tired backlash wind in spite of the rain, changes wet clothing not in time, summer and autumn not cover of sleeping have a cold.In the course of time, the tissue degeneratiaon got involved can be made, cause the chronic back pain that touching difficulty heals.Lumbago due to pathogenic wind-dampness is apt to occur in muscle, muscle arteries and veins, ligament, fat and subcutaneous tissue.The topmost symptom of lumbago due to pathogenic wind-dampness is lumbago, and waist is sent out heavy, as there being weight to drop, after tired or overcast and rainyly to increase the weight of, takes a turn for the better when fine day or warmer climate; Waist is bent forward and backward active receiving restriction, can not sitting for a long time; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold.

Motherland's medical science is thought, pain refers to waist being invaded by exogenous pathogen, or because of impairment caused by overstrain, or causing QI-blood circulation to lack of proper care by suffering from a deficiency of the kidney, spasm of collateral, waist mansion is lost and is supported the caused class disease being cardinal symptom with waist one or both sides pain.Lumbago all can occur throughout the year, and its sickness rate is higher, has report to think that 80% of world population suffered from lumbago and backache abroad.Lumbago one is sick, and ancient literature early has discussion, and " Plain Questions arteries and veins wants precise and tiny opinion " points out: " incapable of turning round, kidney is by exhausted for waist person, house of kidney." describe the feature of lumbago due to renal deficiency." Plain Questions thorn lumbago " thinks that lumbago mainly belongs to the disease of sufficient the six channels, and when having set forth foot three sun, foot three the moon and eight extra-channel meridians pathological changes respectively, the corresponding acupuncture and moxibustion therapy of characteristic sum of lumbago occurs."Nei Jing" also describes the character of lumbago, position and scope respectively at other chapters, and propose the cause of disease based on empty, tremble with fear, wet." Medical Treasures of the Golden Chamber " has started to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs to lumbago, and wound lumbago due to renal deficiency shenqi pill, lumbago due to cold-damp Rhizoma Zingiberis Siberian cocklebur art soup treatment, two sides are always by later age is paid attention to.Sui's " General Treatise on the Cause and Symptoms of Diseases ", in etiology, has enriched the cause of disease such as " waist is hindered by pendant Sui ", " straining in kidney ", classification has been divided into sudden onset of lumbago and chronic lumbago.Tang's Thousand Golden Prescriptions " medical secrets of official " adds massage, content such as a surname guide therapeutic and nursing etc.Jin and Yuan dynasty, relatively more abundant to the understanding of lumbago, as " danxi's experiential therapy lumbago " points out that lumbago diseases is because having " damp and hot, suffer from a deficiency of the kidney, blood stasis, frustrate sudden strain of a muscle, accumulation of phlegm ", and emphasize the important function of suffering from a deficiency of the kidney.The Qing Dynasty, to understanding and the abundant clinical experience of lumbago etiology and pathogenesis and Therapy regularity existed system." seven loose rock collection lumbagos " is pointed out: " so pain have deficiency and excess point, so-called empty person, be the spiritual asthenia of qi and blood of two kidneys also, all speech deficiency syndrome, all two kidneys are from sick ear.So-called real person, non-kidney man, from real, is among two waist meridians blood vessels, and the institute wet for wind and cold invades, and dodges the institute that Na frustrates gas and hinders, and among waist internal cavity, for damp-phlegm blood stasis stagnates obstructed and be pain, distinguishes and knows when foundation arteries and veins is demonstrate,proved and divide and rule it." to lumbago commonly encountered diseases because of and typing done summary." Zhengzi Huibu lumbago " is pointed out: " only the kidney invigorating is for first, then with the finding person of heresy to treat, mark symptomatic treatment in acute condition, this urgency is then effected a permanent cure, and just pain should be dredged evil stagnant, and reason channel tunnel, bitterly should mend true strength for a long time, nourish blood gas." thisly distinguish specimen Therapeutic Principle in the order of urgency, to highly significant clinical.

Etiology and pathogenesis: 1, exopathogen invasion and attack are how moist by residence, or work exposure to wind when sweating, clothing is wrapped up in cold wet, or catch a cold in spite of the rain, or the season of long summer, work in damp and hot friendship and steam part, the void of work taken advantage of by the evil poison of the six climate exopathogens such as cold-damp, damp and hot, summer-heat, invasion and attack waist mansion, causes waist passages through which vital energy circulates to be obstructed, and QI and blood is not smooth and lumbago occurs.If cold-evil is disease, cold impairment of YANG, main spasm, waist mansion yang-energy is both empty, and channels is stopped up again and held back contracture therefore raw lumbago.If damp is disease, moist heavy, viscous, under become, block up mechanism of qi, waist mansion can be made not all right through the stagnation of QI, the blood network stasis of blood and smooth, so that muscle spasm of muscles and vessels and send out lumbago.Experience damp and hot heresy, thermal burn is cloudy, and wet impairment of YANG, and damp and hot viscous, stop up and hold back passages through which vital energy circulates, strongly fragrant and the not all right and lumbago of QI and blood.2, qi depression to blood stasis waist continues firmly, and too, or long-term position is not just in work, or waist undue force, and get rid of gas sprain and contusion, tumbling down wound, strain waist mansion muscle arteries and veins QI and blood, or prolonged illness people network, QI-blood circulation is smooth, all can make waist obstruction of QI, blood network stasis blocking and raw lumbago.3, the empty natural endowment of deficiency of the kidney body is not enough, and fatigue too in addition, or weakness due to chronic disease, or worn with age, or sexual overstrain, so that deficiency of the kidney, is difficult moisten foster waist Fu Jinmai and lumbago occurs.Ancient Chinese medicine doctor all payes attention to the important pathogenesis that deficiency of the kidney body void is lumbago.As " the infirmity body fluid of Ling Shu Miraculous Pivot or Divine Axis five is other " is said: " empty, therefore lumbago, backache and aching legs." " Jing Yue's complete work lumbago " also think: " deficiency syndrome ten of lumbago occupy eight or nine." waist is house of kidney, is the territory that the vital essence of kidney is irrigate.Exterior and interior relation between kidney and bladder, meridian of Foot-TAI YANG crosses it.In addition, appoint, superintend and direct, rush, be with all arteries and veins, also cloth therebetween, therefore internal injury is not then suffered from a deficiency of the kidney outward.And the damp and hot all heresies of affection of exogenous wind-cold, with damp pathogen being sticky and stagnant in nature, wetting flows down, and the easiest numbness waist, so diseases caused by exogenous pathogenic factor always be unable to do without damp for suffering from.Inside and outside two because of, influence each other, as " miscellaneous diseases source and course rhinoceros candle lumbago diseases source and course " is pointed out: " lumbago, the empty and evil objective disease of vital essence is also.Suffer from a deficiency of the kidney it also, the damp and hot phlegm retention of wind and cold, its mark of qi depression to blood stasis sprain and contusion also, or from mark, or from this, your nothing mistake its should." illustrating that suffering from a deficiency of the kidney is morbidity key point, the numbness resistance that wind and cold is damp and hot is not all right, and Chang Yin suffers from a deficiency of the kidney and objective, though otherwise feel exopathogen, also unlikelyly there is lumbago.Sprain as labour, then relevant with blood stasis, also not rare clinically.

In Chinese medicine, a lumbago point deficiency and excess opinion is controlled, and empty person, based on Bu Shen Zhuang waist, doublely takes good care of QI and blood; Reality person eliminating evil active for want, for the cause of disease, execute with blood circulation promoting and blood stasis dispelling, dispelling cold and removing dampness, rushes down the methods such as damp and hot clearly.Deficiency and excess is held concurrently folder person, knows the secondary from the primary, and giving consideration to both the incidental and fundamental is treated.Lumbago due to cold-damp symptom: waist cold type of pain weighs, changes one's position unfavorable, increases the weight of gradually, the cold rear aggravation of overcast and rainy or waist sense whenever, sore spot happiness temperature, and obtain hot, subtract, tongue is greasy in vain and moisten, deep and tense pulse or heavy slow.Method for the treatment of: dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian.Side's medicine: eliminating dampness by diuresis soup; Lumbago due to damp-heat symptom: waist hip tearing pain, holds up contracture, and sore spot is with hotness, and after often heat summer or waist, pain is acute, meets cold type of pain alkali, feeling thirst but no desire to drink, and urine yellow skin is red, or afternoon fever of the body, slightly sweating, red tongue with yellowish and greasy fur, soft and rapid pulse or stringy and rapid pulse.Method for the treatment of: clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.

At present, the medicine of Modern medical therapy rheumatism can be divided into following a few class:

1, nonsteroidal anti-inflammatory agent (NSAIDs): the effect of this type of medicine, is mainly antipyretic, antiinflammatory and analgesia, and reach reduce inflammation reaction and object.Be that aspirin (aspirin) is so far still for treating the active drug of acute rheumatic fever and rheumatic arthritis the earliest.Produced various Salicylates afterwards, conventional has ibuprofen, diclofenac, indomethacin, piroxicam, naproxen etc., but the pharmacokinetics of various medicine and untoward reaction different, main to gastrointestinal, kidney, liver and blood system, must note dosage during use, usage, side effect etc.

2, adrenocortical hormone: because it not effects a radical cure medicine, long-term a large amount of use can bring out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And easy generation state of an illness rebound phenomenon as too fast in drug withdrawal, therefore should note according to disease kind and the state of an illness, regulate the kind and dosage that use medicine.Except patient with severe symptoms, in principle with low dose, Low doses is advisable.

3. the antirheumatic (DMARDs) improving the state of an illness is also called and acts on antirheumatic slowly.It is different that this type of medicine comprises numerous species structure, acts on different medicine.Their general character is that onset is slow, has certain cumulative action, therefore after drug withdrawal, event resolves is also comparatively slow, still can maintain a period of time.Various medicine internal organs (liver, kidney, bladder, lung, gastrointestinal, gonad) that body weight for humans is wanted and tissue (bone marrow) toxic action of having nothing in common with each other above.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof, Chinese medicine composition of the present invention has effect of dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving, cure mainly lumbago due to pathogenic wind-dampness curative effect best, focus of going directly, has the course for the treatment of shorter, medicament is easy to manufacture, toxic and side effects is little, convenient drug administration, not easily recurs and advantage with low cost more.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.

Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 10-30 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 15-25 weight portion, Rhizoma Et Radix Notopterygii 16-31 weight portion, Radix Angelicae Pubescentis 16-31 weight portion, Radix Angelicae Dahuricae 11-21 weight portion, Radix seu Caulis Jasmini lanceolarii 16-25 weight portion, Capreolus Capreolus (Linnaeus). 16-25 weight portion, Radix Pandani Furcati 16-30 weight portion, Fructus Chaenomelis 16-30 weight portion, Bombyx mori L. 12-25 weight portion, Lignum Pini Nodi 14-25 weight portion, Caulis Sinomenii 16-24 weight portion, Resina Liquidambaris 16-31 weight portion, Radix Salviae Miltiorrhizae 16-25 weight portion, Caulis Viticis Cannabifoliae 12-25 weight portion, Chinese mugwort 12-31 weight portion in thousand, Fructus Liquidambaris 12-20 weight portion, Radix Achyranthis Bidentatae 10-21 weight portion, Caulis Spatholobi 16-31 weight portion and Squama Manis 16-31 weight portion.

Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 15-25 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 17-23 weight portion, Rhizoma Et Radix Notopterygii 18-27 weight portion, Radix Angelicae Pubescentis 18-26 weight portion, Radix Angelicae Dahuricae 13-18 weight portion, Radix seu Caulis Jasmini lanceolarii 18-22 weight portion, Capreolus Capreolus (Linnaeus). 19-21 weight portion, Radix Pandani Furcati 19-26 weight portion, Fructus Chaenomelis 19-26 weight portion, Bombyx mori L. 15-22 weight portion, Lignum Pini Nodi 18-22 weight portion, Caulis Sinomenii 19-23 weight portion, Resina Liquidambaris 19-27 weight portion, Radix Salviae Miltiorrhizae 19-23 weight portion, Caulis Viticis Cannabifoliae 15-22 weight portion, Chinese mugwort 18-26 weight portion in thousand, Fructus Liquidambaris 15-20 weight portion, Radix Achyranthis Bidentatae 15-21 weight portion, Caulis Spatholobi 23-31 weight portion and Squama Manis 20-27 weight portion.

Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portion, Rhizoma Et Radix Notopterygii 22 weight portion, Radix Angelicae Pubescentis 23 weight portion, the Radix Angelicae Dahuricae 16 weight portion, Radix seu Caulis Jasmini lanceolarii 20 weight portion, Capreolus Capreolus (Linnaeus). 20 weight portion, Radix Pandani Furcati 23 weight portion, Fructus Chaenomelis 23 weight portion, Bombyx mori L. 17 weight portion, Lignum Pini Nodi 20 weight portion, Caulis Sinomenii 21 weight portion, Resina Liquidambaris 23 weight portion, Radix Salviae Miltiorrhizae 20 weight portion, Caulis Viticis Cannabifoliae 18 weight portion, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portion, Radix Achyranthis Bidentatae 17 weight portion, Caulis Spatholobi 26 weight portion and Squama Manis 23 weight portion.

In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness, it is characterized in that, the dosage form of described Chinese medicine composition is emplastrum, and described preparation method comprises the following steps:

A, take all raw medicinal materials according to parts by weight, put into ethanol heating and refluxing extraction 3 times, merge three extracting solution and obtain extracting solution one;

B, again by the medicinal residues of ethanol extraction in step a, the heating and refluxing extraction that adds water 2 times, merges 2 extracting solution and obtains extracting solution two;

C, extracting solution one and extracting solution two to be merged, concentrated, obtain extractum, the concentrated modulation of heating.

In described step a, the determining alcohol that the raw medicinal material taken by weight adds raw medicinal material gross weight 5 times is in the ethanol of 85%, heating and refluxing extraction 3 times, each 2-5 hour, is merged by extracting solution and leaves standstill, obtain extracting solution one.

In described step b, the medicinal residues crossed by ethanol extraction in step a add water heating and refluxing extraction 2 times, and each 1-3 hour, merges extracting solution and leave standstill, obtain extracting solution two.

In described step c, extracting solution one and extracting solution two are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.09MPa, being concentrated into relative density when temperature is 60-90 DEG C is 1.03, the extractum of temperature to 75 DEG C-92 DEG C; Continue to heat to concentrate and modulate to obtain emplastrum.

In order to better realize foregoing invention object, invention further provides a kind of preparation method being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness, it is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:

A, take Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis according to parts by weight, add the water soaking 1-3 hour of above-mentioned four kinds of raw medicinal material mixture 3-4 times amount, extract the volatile oil of 1-3 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use;

B, by the medicinal residues in step a and remain other raw medicinal materials mixing, adding alcoholic degree is in the ethanol of 75-80%, soak 1-2 hour, extract twice, each 2 hours, first time adds 4 times that amount of alcohol is mixture, second time adds 7 times that amount of alcohol is mixture, merge extractive liquid, filters; Above two filtered solutions merge and filter, and filtered solution is evaporated to 1.13-1.50 precipitate with ethanol when relative density is 88 DEG C, adjust concentration of alcohol to 73-96%, 1.13-1.50 when to get supernatant concentration to relative density be 88 DEG C, obtains extractum;

C, get the extractum that step b obtains, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mixing, grind 10 minutes with colloid mill, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtains described capsule.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention is based on dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving, it is best that treatment lumbago due to pathogenic wind-dampness has curative effect, the through focus of energy, the course for the treatment of is shorter, medicament is easy to manufacture, toxic and side effects is little, convenient drug administration, not easily recurs and advantage with low cost more.

Detailed description of the invention

Chinese medicine external therapy is one of the most frequently used clinically external treatment of Chinese medicine, " Handbook of Prescriptions for Emergencies " of Jin Daige flood work, the Thousand Golden Prescriptions of the Tang Dynasty Sun Simiao, supplement to Thousand Golden Prescriptions, in " medical secrets of official " of Wang Taozhu and the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.), contained therapy has all related to Chinese medicine external therapy.Because meridians have interior genus internal organs, outer network podomere, link up the exterior and the interior, run through upper and lower effect, so not only local patholoic change can be treated, but also reach the object for the treatment of systemic disease by external application.Medicine, by the stimulation to acupuncture point, local, penetrates through skin, excites through feeling pulse gas, promotes internal organs QI-blood circulation, plays therapeutical effect; Skin is thinner, nerve, blood vessel are abundanter, therefore absorbability more by force and is rapidly had, there are good impression and conduction function, when treat with suitable medicine in time, the equal teleneuron that can stimulate local, improves internal organs and tissue physiology is movable and pathological change, the immunity of enhancing body and resistance against diseases.Chinese medicine external avoids oral and injects the inconvenience that brings and painful and lasting medicine, avoids the first pass effect of liver and the interference of gastrointestinal factor and Degradation, reduces individual variation, rapid-action, strong drug action, hurtless measure, and no pain is easy to use.

The traditional Chinese medical science thinks that a lumbago point deficiency and excess opinion is controlled, and empty person, based on Bu Shen Zhuang waist, doublely takes good care of QI and blood; Reality person eliminating evil active for want, for the cause of disease, execute with blood circulation promoting and blood stasis dispelling, dispelling cold and removing dampness, rushes down the methods such as damp and hot clearly.Deficiency and excess is held concurrently folder person, knows the secondary from the primary, and giving consideration to both the incidental and fundamental is treated.The present invention with dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving for primary treatment principle, provide a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness, comprise Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.

Wherein, the pharmacological property of each raw medicinal material is as follows:

Ramulus Cinnamomi: pungent, sweet, warm in nature; Enter bladder, the heart, lung meridian." Amplification on Materia Medica addendum ": " Zhong Jingzhi table Ramulus Cinnamomi, non-table has void to mend it with osmanthus; Defend ailment said due to cold or exposure, therefore sick spontaneous perspiration, send out its heresy with Ramulus Cinnamomi, defend and then show close antiperspirant from stopping, non-Ramulus Cinnamomi can be received antiperspirant and control it." Compendium of Material Medica: " and Herba Ephedrae all over thorough fur, therefore specially in diaphoresis, cold-evil falls apart, lung governing skin and hair, pungent walk lung also.Ramulus Cinnamomi thoroughly reaches battalion and defends, therefore can expelling pathogenic factors from muscles and ailment said due to cold or exposure is gone, and spleen is managed mainly, and lung master defend, sweet walk spleen, pungent walk lung also." " book on Chinese herbal medicine converge with speech ": " by pathogenic factor in the exterior, send out antiperspirant evil, cough-relieving is coughed, and removes the medicine of wind pain between podomere also for Ramulus Cinnamomi, dispersing wind and cold.Though abnormal smells from the patient is not from hot, body belongs to branch, only can disperse between the fur flesh natural fibre line of meat, parade arm knee joint podomere part." function diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea is suffered from abdominal pain; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.

Paphiopedilum parishii(Rchb. F.) Pfitz: pungent; Bitter; Flat.Return: lung; Stomach; Kidney channel.Function cures mainly: relieving cough and asthma; Wind-expelling pain-stopping.Main pulmonary tuberculosis; Cough; Heavy breathing Zhong chuan; Rheumatic ostalgia; Gastroenteritis.

Rhizoma Et Radix Notopterygii: acrid in the mouth, bitter, warm in nature; Enter bladder, kidney channel." property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." " product remittance essence is wanted ": " main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." " Thunder God concoct the property of medicine solution ": " Rhizoma Et Radix Notopterygii gas belongs to clearly sun, benefaction edema caused by disorder of QI, relaxes and does not hold back, and rises and can sink, male and be apt to fall apart, and can deliver heresy, therefore sun small intestinal of starting with.Foot sun bladder is to manage urticaria, though if its function is different from Radix Angelicae Pubescentis, reality is the exterior and the interior mutually." function falls apart exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects. and after gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.

Radix Angelicae Pubescentis: expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.Anemofrigid-damp arthralgia.The pungent loose hardship of these product is dry, and the fragrant temperature of gas is logical, and merit is apt to Eradicates rheumatism, stopping numbness pain, is dispelling the wind and dampness pathogens arthralgia pain principal agent, the arthromyodynia that all wind-cold damp pathogens are caused, no matter for a long time new, all can apply; Enter kidney channel because it is main, property is apt to descending, is especially advisable with waist knee joint, lower limb joints of foot pain subordinate portion cold-damp person.Control the anemofrigid-damp arthralgia of the damp that is affected by the cold, muscle, back, brothers' pain, be often equal to use with Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, as Radix Angelicae Pubescentis soup (" young new book of living "); If with compatibilities such as Herba Taxilli, the Cortex Eucommiae, Radix Ginsengs, arthromyodynia can be controlled with the passing of time weakened body resistance, soreness of the waist and knees, joint joint stuffiness person, as Radix Angelicae Pubescentis et Herba Taxilli Decoction (" prescriptions worth thousand gold ").Wind and cold holds wet exterior syndrome under the arm.The pungent loose temperature of these product is logical bitter dry, can dispersing wind and cold wet and induce sweat, controlling affection of exogenous wind-cold, to hold wet caused headache under the arm nose heave, all over the body pain to the greatest extent.SHAO YIN headache.These product are apt to search volt wind into kidney channel.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel." Japan hanako materia medica ": " control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, scabies, desolation, pain relieving granulation promoting, go face Shao-defect scar." Compendium of Material Medica: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, married woman's blood dizziness due to wind pathogen is transported, bleeding urine, and regurgitation of food from the stomach tells food; Solution arsenic poison, snakebite, cutter arrow incised wound." function expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.Can improve microcirculation in human body, promote skin metabolism, and the water soluble ingredient of the Radix Angelicae Dahuricae has vasoconstrictor effects, the Coumarins composition byak-angelicin of the Radix Angelicae Dahuricae has dilating effect to coronary vasodilator.

Radix seu Caulis Jasmini lanceolarii: property is put down, and bitter in the mouth is pungent.Warm in nature, bitter in the mouth is nontoxic.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens waist condyle pain, traumatic injury, sore, carbuncle.1. " classify herbal ": " dispelling the wind and dampness pathogens, and blood vessels pain all over the joints; Heat clearing away, controls wind syndrome of head pain." 2. " will planted by middle traditional Chinese medicines ": " controls traumatic injury, has and bores the deep effect of muscle: cure mainly lumbago, skelalgia etc., also have the usefulness of middle wind and cold of boning." 3. " Traditional Chinese Medicine in Sichuan will ": " treats bones and muscles pain due to rheumatism, lumbago, the hematocele after loose bone breaks, and controls wind syndrome of head."

Capreolus Capreolus (Linnaeus).: sweet in the mouth; Salty; Warm in nature.Return kidney channel.Function cures mainly: kidney-replenishing; Benefiting essence-blood; Bone and muscle strengthening.Main asthenia is frail; Soreness of the waist and knees; Bones and muscles pain; Sexual impotence; Infertile.

Radix Pandani Furcati: sweet light, cool.Function cures mainly: clearing away heat and promoting diuresis, diaphoresis pain relieving.Cure cold heating, urinary tract infection, oedema due to nephritis, conjunctivitis, hepatitis, lumbago, skelalgia of rheumatism, colicky.

Fructus Chaenomelis: sour in the mouth, warm in nature, nontoxic; Return liver, spleen channel." modern Practical Chinese medicinal ": " crude fruit liquid, controls gastric indigestion, and is nutriment, is again agent of stimulating the secretion of milk.Ripe fruit, can sharp defecation, also can control red-white dysentery." " food book on Chinese herbal medicine ": " main promoting the circulation of QI, loose stagnant blood, treats pained, separates heat stagnation." Fructus Chaenomelis has good relaxing muscles and tendons and activating QI and blood in the collateral effect, and energy removing dampness, by dispelling the wind and dampness pathogens arthralgia pain is commonly used, muscle arteries and veins contracture person particularly key medicine.Papaya powder can alleviate the liver cell fatty degeneration and hepatic necrosis that rat skin lower injection carbon tetrachloride causes, and prevents swelling of liver cell and balloon sample from becoming, can promote hepatocellular reparation, SGPT is significantly reduced.There is remarkable inhibitory action to multiple intestinal and staphylococcus, also have obvious inhibitory action to Diplococcus pneumoniae and tubercule bacillus.Carpaine has the effect alleviating spasm pain, has obvious therapeutical effect for sural spasm.

Bombyx mori L.: acrid in the mouth, sweet, warm in nature.Compendium of Material Medica: " control and quench one's thirst, crux, and married woman's metrorrhagia, wind syndrome of head, blepharitis marginalis, goes wind to dehumidify." supplement to the Herbal: " parching to brown, infusing drugs in wine contained by bag, goes wind to delay all joints unsuccessful, the stupid paralysis of skin, Su Leng in abdomen, cold-blooded blood stasis, and waist foot pain is cold." dispeiling pathogenic wind and removing dampness, heat clearing and blood circulation promoting.Dispelling the wind and dampness pathogens, munbness, joint is unsuccessful, convulsion of sharply vomiting and diarrhoea, and muscles and bones is unsuccessful, blood stasis, wind syndrome of head acute conjunctivitis in lumbar and pedal pain, abdomen.This product pungent and sweet flavors can be used for dispersing, can Eradicates wind, warm-dryness syndrome and leading to, kind dehumidifying relaxing muscles and tendons again, and effect relaxes, and can be used for various arthromyodynia." prescriptions worth thousand gold " alone steaming, more presses affected part, and with dispelling the wind and dampness pathogens arthralgia pain, limbs are unsuccessful.Enter taste, can stomach function regulating removing dampness, wetly to go, have loose bowels can stop, muscle arteries and veins can relax.

Lignum Pini Nodi: bitter, temperature; Enter heart channel, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " network of passing through, controls phlegm-fire, bones and muscles pain, and arthralgia chiefly caused by damp pathogen flaccidity is soft, bone and muscle strengthening." " Japan hanako materia medica ": " controls foot chondromera wind." " book on Chinese herbal medicine converges and says ": " Lignum Pini Nodi, temperature is dry, as sufficient knee joint muscles and bones, has wind to have wet, acid of having a pain, the weak unable person of flaccidity, stands fully recover from an illness with this.If deficiency of YIN marrow is weary, blood is dry fiery person, should consider and use it." function dispeiling pathogenic wind and removing dampness, pain relieving.Cure mainly anemofrigid-damp arthralgia, severe and migratory arthralgia pain, foot numbness flaccidity is soft, traumatic pain.Lignum Pini Nodi has certain analgesia, antiinflammatory action; The acidic polysaccharose display antitumor action extracted; The polysaccharose substance extracted, hot water extract, acidic extraction thing all have immunocompetence.

Caulis Sinomenii: bitter, pungent; Return liver, spleen channel.Compendium of Material Medica: " paralysis pruritus, damage skin ulcer swells, and enters in yeast for brewing rice wine and uses for dispelling the wind and dampness pathogens multiple abscess, severe and migratory arthralgia crane knee joint." " will planted by Tianmu Mountains of Zhejiang Province medicine ": " row water diuresis, it is damp and hot to rush down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system.Control edema caused by wind, beriberi, Fengshi Guanjie pain, facial hemiparalysis, carbuncle malignant boil." function wind-damp dispelling, the meridian dredging, diuresis.For rheumatic arthralgia, arthroncus, paralysis pruritus.Caulis Sinomenii dispersing wind and cold arthralgia chiefly caused by damp pathogen, energy relaxing muscles and tendons to promote blood circulation, boneset sharp marrow, therefore syndrome caused by wind pathogen weakness, and the card that strength is attached undue importance to one thing to the neglect of the other by force, take informal dress for a long time, make outstanding contributions greatly.Must be apt to also with Radix Angelicae Sinensis, the Fructus Lycii side of share.Sinomenine, in the test with mice electrostimulation, hot plate method and rabbit photo-thermal stimulus method, all proves the analgesic activity with affirmative.Sinomenium acutum total alkali is to anesthesia or not anaesthesia experiment animal (dog, cat, rabbit, rat), and intravenous injection or gavage all have the acute antihypertensive effect of affirmative.

Resina Liquidambaris: pungent is bitter, flat; Return spleen, lung, Liver Channel.Function expelling wind and activating blood circulation, removing toxic substances pain relieving, hemostasia and promoting granulation.For carbuncle, skin ulcer rash, scrofula, toothache, arthralgia pain, paralysis, spits blood, epistaxis, spitting of blood, traumatic hemorrhage, chapped skin.Resina Liquidambaris and volatile oil experiment in vitro thereof can make Sanguis Leporis seu oryctolagi bolt contraction in length and weight (weight in wet base and dry weight) alleviate, and experiments in vivo display can obviously suppress rat suppository to be formed; Test tube method experiment shows to significantly improve plasmin activity, significantly improves cAMP content in platelet.Show Resina Liquidambaris and volatile oil anti thrombotic action thereof and promotion fibrinolytic and improve platelet cAMP relevant, and point out volatile oil may be the main hemostatic compositions of Resina Liquidambaris.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enters the heart, Liver Channel, has the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as interior fat and testis peripheral adipose, alleviates insulin secretion and glycometabolic Random early Detection.Strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.Coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow declines, and improves plasmin activity; Extend bleeding and cotting time; Anticoagulant (improve cAMP level in platelet and suppress TXA2 synthesis); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time are shortened).Radix Salviae Miltiorrhizae Tabellae is the Chinese patent medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain.The disease such as be mainly used in angina pectoris, hypertension, cervical spondylosis and feel oppressed in the heart.And the side effect that is reliable, Radix Salviae Miltiorrhizae Tabellae of its drug effect is little.But that can not eat is too frequent.Because long-term taking FUFANG DANSHEN PIAN may cause blood potassium content to reduce, produce hypokalemia.

Caulis Viticis Cannabifoliae: acrid in the mouth; Micro-hardship; Property is put down.Return: lung; Liver; Spleen; Stomach warp.Function cures mainly: expelling pathogenic wind from the body surface; Reducing swelling and alleviating pain.Main flu; Sore throat; Toothache; Foot gas; Skin ulcer swells; Burn.

Chinese mugwort in thousand: pungent, bitter, tepor.Function cures mainly: expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, relieving cough and resolving phlegm.For anemofrigid cold, measles, Fengshi Guanjie pain, stomachache, bronchitis, pertussis, furuncle swelling toxin, mastitis.

Fructus Liquidambaris: bitter is flat; Return liver, kidney channel." detailed outline is picked up any lost article from the road ": " maple fruit, tree like Cortex Populi dividianae, inner circle as honeycomb, i.e. Fructus Liquidambaris.The large acupoints of twelve meridians that can pass through of its property, therefore " the lifesaving sea of bitterness " harnesses the river, swelling is with it, can search by FUSHUI also with it." " modern Practical Chinese medicinal ": " ashing is outer for skin exudative dermatitis, anal fistula etc., has convergence, antiinflammatory, disinfective action." dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.The property of Fructus Liquidambaris tool tonneau, function promoting the circulation of QI to alleviate the stagnation in middle-JIAO and pain relieving, clinically for abdominal distention, the disease such as not well of defecating.This product has again effect of inducing diuresis to remove edema, for edema, can with the compatibilities such as Cortex Sclerotii Poriae, Cortex Mori, Exocarpium Benincasae.In addition, the property of this product tonneau also can catharsis milk, for stagnation of QI-blood, galactostasis.

Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is put down; Return liver, kidney channel." Japan hanako materia medica ": " control waist knee joint soft timid cold weak, broken crux, evacuation of pus pain relieving, puerperal cardiac and abdominal pain blood fortune, fall tire, tonifying YANG." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control furuncle, carbuncle, apply affected part.Also can have an abortion.Food is simmered, energy improving eyesight with Carnis Sus domestica." there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite (blood) is descending, effect of inducing diuresis for treating stranguria syndrome, the inclined nourishing the liver and kidney of Radix Achyranthis Bidentatae merit, strong waist knee joint: the soreness of bones and muscles, the lumbocrural pain that cause for deficiency of the liver and kindey.Radix Cyathulae is with promoting blood circulation to restore menstrual flow, and wind-damp dispelling is good at: for blood stasis amenorrhea and rheumatalgia.This moral character is apt to descending, and fire and the top of specially controlling inflammation are hemorrhage, therefore is usually used in the disease such as conjunctival congestion, pharyngeal swelling, haematemesis, epistaxis of hyperactivity of deficient fire or heat in blood upper punch.The traditional Chinese medical science is thought, its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws effect that blood (fire) is descending, be usually used in the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain for the treatment of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, the cards such as the headache that Urethra astringent pain and burning hot upper inflammation cause, dizzy, haematemesis, epistaxis.

Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.Pharmacological action: to the effect of hemopoietic system; To the effect of blood coagulation, fibrinolytic; Suppress heart and the effect of reducing blood pressure; Antitumaous effect; To the adjustment of lipid metabolism.

Squama Manis: salty in the mouth, cold nature; Return liver, stomach warp." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control mange carbuncle poison, dispelling the stagnated QI promoting the circulation of blood, chest and diaphragm expands against gas, controls bladder hernia pain." Compendium of Material Medica: " and except intermittent fever due to phlegm cold and heat, the tetanic pain of migratory arthralgia, qualcomm meridian, lower milk, subduing inflammation, evacuation of pus blood, sensible parasite killing." blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula.Squama Manis has preferably catharsis milk effect, and for galactostasis in puerperal, can single be end, yellow wine takes.For strengthening stimulating milk secretion effect; If puerperal QI and blood deficiency, milk is rare.Squama Manis has effect of detumescence and apocenosis, and carbuncle can be made not become pus, and person disappears, and suppuration person's speed is burst.

Embodiment 1 emplastrum

Embodiments provide a kind of Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portion, Rhizoma Et Radix Notopterygii 22 weight portion, Radix Angelicae Pubescentis 23 weight portion, the Radix Angelicae Dahuricae 16 weight portion, Radix seu Caulis Jasmini lanceolarii 20 weight portion, Capreolus Capreolus (Linnaeus). 20 weight portion, Radix Pandani Furcati 23 weight portion, Fructus Chaenomelis 23 weight portion, Bombyx mori L. 17 weight portion, Lignum Pini Nodi 20 weight portion, Caulis Sinomenii 21 weight portion, Resina Liquidambaris 23 weight portion, Radix Salviae Miltiorrhizae 20 weight portion, Caulis Viticis Cannabifoliae 18 weight portion, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portion, Radix Achyranthis Bidentatae 17 weight portion, Caulis Spatholobi 26 weight portion and Squama Manis 23 weight portion.

The Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness is emplastrum, and its preparation method comprises the following steps:

The determining alcohol that a, the raw medicinal material taken by weight add raw medicinal material gross weight 5 times is in the ethanol of 85%, heating and refluxing extraction 3 times, each 4 hours, is merged by extracting solution and leaves standstill, obtain extracting solution one;

B, the medicinal residues crossed by ethanol extraction in step a add water heating and refluxing extraction 2 times, each 2 hours, are merged by extracting solution and leave standstill, obtain extracting solution two;

C, extracting solution one and extracting solution two are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.06MPa, being concentrated into relative density when temperature is 75 DEG C is 1.03, the extractum of temperature to 83 DEG C; Continue to heat to concentrate and modulate to obtain emplastrum.

Embodiment 2 capsule

The Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 30 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 25 weight portion, Rhizoma Et Radix Notopterygii 16 weight portion, Radix Angelicae Pubescentis 16 weight portion, the Radix Angelicae Dahuricae 21 weight portion, Radix seu Caulis Jasmini lanceolarii 25 weight portion, Capreolus Capreolus (Linnaeus). 25 weight portion, Radix Pandani Furcati 16 weight portion, Fructus Chaenomelis 30 weight portion, Bombyx mori L. 25 weight portion, Lignum Pini Nodi 14 weight portion, Caulis Sinomenii 24 weight portion, Resina Liquidambaris 31 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Caulis Viticis Cannabifoliae 25 weight portion, Chinese mugwort 12 weight portions in thousand, Fructus Liquidambaris 12 weight portion, Radix Achyranthis Bidentatae 10 weight portion, Caulis Spatholobi 16 weight portion and Squama Manis 31 weight portion.

The above-mentioned dosage form being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness is capsule, and its preparation method comprises the following steps:

A, take Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis according to parts by weight, add the water soaking 3 hours of above-mentioned four kinds of raw medicinal material mixture 4 times amount, extract the volatile oil of 2 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use;

B, by the medicinal residues in step a and remain other raw medicinal materials mixing, adding alcoholic degree is in the ethanol of 75%, soak 1-2 hour, extract twice, each 2 hours, first time adds 4 times that amount of alcohol is mixture, second time adds 7 times that amount of alcohol is mixture, merge extractive liquid, filters; Above two filtered solutions merge and filter, and filtered solution is evaporated to 1.30 precipitate with ethanol when relative density is 88 DEG C, adjusts concentration of alcohol to 73%, 1.13-1.50 when to get supernatant concentration to relative density be 88 DEG C, obtains extractum;

C, get the extractum that step b obtains, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for 3% of extractum and volatile oil gross mass, mixing, grind 10 minutes with colloid mill, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtains described capsule.Every capsules 0.4g.

Pharmacology pharmacodynamic is tested:

1, cumulative toxicity test report

Test method: select 20 healthy mices, female, each 10 of hero, with the capsule of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.

2, acute toxicity test: with the capsule of the embodiment of the present invention 2 for object, gives white mouse large enteral dispensing, observes 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.

3, according to Ministry of Public Health " cosmetics health specification " (2002) Part II " acute dermal toxicity test " test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, by the emplastrum that the embodiment of the present invention 1 obtains, one time percutaneous smears 5000mg/kg body weight dose, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

4, according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the emplastrum getting the 0.5g embodiment of the present invention 1 directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

5, get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The emplastrum 0.1g getting the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Clinical trial

1, data and method

1.1 physical data: during selecting in July ,-2012 in May, 2010, the lumbago due to pathogenic wind-dampness patient of diagnosis and treatment is totally 450 examples, all meets the diagnostic criteria of lumbago due to pathogenic wind-dampness after diagnosing: waist weighs, aches, and after tired or overcast and rainyly to increase the weight of, fine day or warmer climate take a turn for the better; Waist active receiving of bending forward and backward pins down, and sitting standing for a long time can not; Dynamic then tired weak, affected part is afraid of cold; Pale tongue, tongue is greasy in vain, and arteries and veins scholar is delayed.Wherein, man 189 example, female 261 example, age 30-45 year person 76 example, age 46-55 year person 134 example, age 56-65 year person 155 example, more than 66 years old person 85 example.Clinical manifestation is: lumbago, and waist is sent out heavy, as there being weight to drop, after tired or overcast and rainyly to increase the weight of, takes a turn for the better when fine day or warmer climate, can not sitting for a long time; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold.Choose 420 routine patients, be divided into four groups at random, be respectively treatment group 1-3 and matched group, often organize 105 routine patients.Four groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and treats according to the weight of the state of an illness.

1.2 criterion of therapeutical effect

Recovery from illness disappears completely for symptom, and waist functional rehabilitation is normal; Effectively substantially to disappear for symptom, otherwise function recovers normal without sense of discomfort substantially; Transfer symptom to well to alleviate, waist function is improved; Invalid is that before and after treatment, symptom and waist function are not any change.

1.3 Therapeutic Method and therapeutic effect

1.3.1 treatment group 1-2 uses the Chinese medicine composition of the different preparation of embodiment of the present invention 1-2 to treat respectively, and treatment group 3 uses the Chinese medicine composition of the embodiment of the present invention 1 and embodiment 2 to treat simultaneously:

(1) treatment group 1:105 example patient uses the emplastrum of the embodiment of the present invention 1, after cleaning waist, by emplastrum beach on preservative film or gauze, fix with medical adhesive tape or binder, one day twice, each use 3-6 hour, continuous use 10-15 days, drug withdrawal is further consultation again after one week.The routine patient of statistics discovery 65 all fully recovers, and 20 routine patients are effective, and 18 routine patients are effective, and 2 routine patients are invalid.Treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, and patient is all without any relapse indications in recovery from illness.

(2) treatment group 2:105 example patient uses the capsule of the embodiment of the present invention 2, three times on the one, once takes 2-4 grain, and use 10-15 days continuously, drug withdrawal is further consultation again after one week.The routine patient of statistics discovery 64 all fully recovers, and 26 routine patients are effective, and 13 routine patients are effective, and 2 routine patients are invalid.Treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, and patient is all without any relapse indications in recovery from illness.

(3) treatment group 3:105 example patient uses the emplastrum of the embodiment of the present invention 1 and the capsule of embodiment 2 simultaneously, after cleaning waist, by emplastrum beach on preservative film or gauze, fix with medical adhesive tape or binder, once-a-day, each use 3-6 hour, capsule three times on the one, once take 2-4 grain, use 8-12 days continuously, drug withdrawal is further consultation again after one week.The routine patient of statistics discovery 78 all fully recovers, and 17 routine patients are effective, and 10 routine patients are effective.Treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, and patient is all without any relapse indications in recovery from illness.

1.3.2 the patient of matched group uses nonsteroidal anti-inflammatory agent ibuprofen 400mg, every day three times, each two, and use 15 days continuously, drug withdrawal is further consultation again after one week, and the routine patient's recovery from illness of statistics discovery 38,19 routine patients are effective, and 42 routine patients take a turn for the better, and 6 routine patients are invalid.Follow up a case by regular visits to half a year, statistics recurs after finding wherein to fully recover and having 6 routine patient's drug withdrawals in patient; 7 routine patients are had to occur the side effect such as stomachache, dyspepsia at treatments period.

Known by above-mentioned clinical trial: compared with traditional Western medicine for the treatment of lumbago due to pathogenic wind-dampness, the Chinese medicine composition of embodiment of the present invention 1-2 have healing time short, cure after the advantage that not easily recurs and have no side effect.

2, concrete case

Case 1: Lin, man, 57 years old, lumbago, waist is sent out heavy, as there being weight drop, tired to take a turn for the better when fine day or warmer climate afterwards or overcast and rainyly to increase the weight of, can not sitting for a long time; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold, about above-mentioned symptom continues half a year.Use the emplastrum treatment of the embodiment of the present invention 1, after cleaning waist, by emplastrum beach on preservative film or gauze, fix with medical adhesive tape or binder, one day twice, each use 4 hours, use 12 days continuously, drug withdrawal is further consultation again after one week.Symptom all disappears, waist functional rehabilitation, and treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, without any relapse indications.

Case 2: Chen, female, 67 years old, lumbago, waist is sent out heavy, after tired or overcast and rainyly to increase the weight of, takes a turn for the better when fine day or warmer climate, can not sitting for a long time; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold, pale tongue, and tongue is greasy in vain, and arteries and veins scholar is delayed.Use the emplastrum of the embodiment of the present invention 1 and the capsule treatment of embodiment 2 simultaneously, after cleaning waist, by emplastrum beach on preservative film or gauze, fix with medical adhesive tape or binder, one day twice, each use 3 hours, capsule three times on the one, once take 2-4 grain, use 10 days continuously, drug withdrawal is further consultation again after one week.Symptom all disappears, waist functional rehabilitation, and treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, without any relapse indications.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (6)

1. be used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 10-30 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 15-25 weight portion, Rhizoma Et Radix Notopterygii 16-31 weight portion, Radix Angelicae Pubescentis 16-31 weight portion, Radix Angelicae Dahuricae 11-21 weight portion, Radix seu Caulis Jasmini lanceolarii 16-25 weight portion, Capreolus Capreolus (Linnaeus). 16-25 weight portion, Radix Pandani Furcati 16-30 weight portion, Fructus Chaenomelis 16-30 weight portion, Bombyx mori L. 12-25 weight portion, Lignum Pini Nodi 14-25 weight portion, Caulis Sinomenii 16-24 weight portion, Resina Liquidambaris 16-31 weight portion, Radix Salviae Miltiorrhizae 16-25 weight portion, Caulis Viticis Cannabifoliae 12-25 weight portion, Chinese mugwort 12-31 weight portion in thousand, Fructus Liquidambaris 12-20 weight portion, Radix Achyranthis Bidentatae 10-21 weight portion, Caulis Spatholobi 16-31 weight portion and Squama Manis 16-31 weight portion,

The dosage form of described Chinese medicine composition is emplastrum, and the preparation method of described Chinese medicine composition comprises the following steps:

A, take all raw medicinal materials according to parts by weight, put into ethanol heating and refluxing extraction 3 times, merge three extracting solution and obtain extracting solution one;

B, again by the medicinal residues of ethanol extraction in step a, the heating and refluxing extraction that adds water 2 times, merges 2 extracting solution and obtains extracting solution two;

C, extracting solution one and extracting solution two are merged, concentrated, obtain extractum, heating is concentrated modulates to obtain emplastrum.

2. the Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 15-25 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 17-23 weight portion, Rhizoma Et Radix Notopterygii 18-27 weight portion, Radix Angelicae Pubescentis 18-26 weight portion, Radix Angelicae Dahuricae 13-18 weight portion, Radix seu Caulis Jasmini lanceolarii 18-22 weight portion, Capreolus Capreolus (Linnaeus). 19-21 weight portion, Radix Pandani Furcati 19-26 weight portion, Fructus Chaenomelis 19-26 weight portion, Bombyx mori L. 15-22 weight portion, Lignum Pini Nodi 18-22 weight portion, Caulis Sinomenii 19-23 weight portion, Resina Liquidambaris 19-27 weight portion, Radix Salviae Miltiorrhizae 19-23 weight portion, Caulis Viticis Cannabifoliae 15-22 weight portion, Chinese mugwort 18-26 weight portion in thousand, Fructus Liquidambaris 15-20 weight portion, Radix Achyranthis Bidentatae 15-21 weight portion, Caulis Spatholobi 23-31 weight portion and Squama Manis 20-27 weight portion.

3. the Chinese medicine composition being used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portion, Rhizoma Et Radix Notopterygii 22 weight portion, Radix Angelicae Pubescentis 23 weight portion, the Radix Angelicae Dahuricae 16 weight portion, Radix seu Caulis Jasmini lanceolarii 20 weight portion, Capreolus Capreolus (Linnaeus). 20 weight portion, Radix Pandani Furcati 23 weight portion, Fructus Chaenomelis 23 weight portion, Bombyx mori L. 17 weight portion, Lignum Pini Nodi 20 weight portion, Caulis Sinomenii 21 weight portion, Resina Liquidambaris 23 weight portion, Radix Salviae Miltiorrhizae 20 weight portion, Caulis Viticis Cannabifoliae 18 weight portion, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portion, Radix Achyranthis Bidentatae 17 weight portion, Caulis Spatholobi 26 weight portion and Squama Manis 23 weight portion.

4. the preparation method being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to any one of claim 1-3, it is characterized in that, in described step a, the determining alcohol that the raw medicinal material taken by weight adds raw medicinal material gross weight 5 times is in the ethanol of 85%, heating and refluxing extraction 3 times, each 2-5 hour, merges extracting solution and leaves standstill, obtain extracting solution one.

5. the preparation method being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to any one of claim 1-3, is characterized in that, in described step b, the medicinal residues crossed by ethanol extraction in step a add water heating and refluxing extraction 2 times, each 1-3 hour, merges extracting solution and leaves standstill, obtain extracting solution two.

6. the preparation method being used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to any one of claim 1-3, it is characterized in that, in described step c, extracting solution one and extracting solution two are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.09MPa, being concentrated into relative density when temperature is 60-90 DEG C is 1.03, the extractum of temperature to 75 DEG C-92 DEG C; Continue to heat to concentrate and modulate to obtain emplastrum.