CN103656735A - Antibacterial hemostatic gauze and preparation method thereof - Google Patents
Antibacterial hemostatic gauze and preparation method thereof Download PDFInfo
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- CN103656735A CN103656735A CN201210354248.9A CN201210354248A CN103656735A CN 103656735 A CN103656735 A CN 103656735A CN 201210354248 A CN201210354248 A CN 201210354248A CN 103656735 A CN103656735 A CN 103656735A
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Abstract
The invention relates to antibacterial hemostatic gauze and a production method thereof. The guaze is produced by performing a special antibacterial pretreatment on medical gauze and selecting a proper antibacterial finishing agent through a special production process. The antibacterial hemostatic gauze has the advantages of simple preparation process, convenience in use, effective anti-bacteria, hemostasis and pain-relieving performances, wound healing promotion, ventilation and comfort and the like, and is applicable to surgical operation, burn department, traumatic wound binding caring.
Description
technical fieldthe present invention relates to a kind of antibacterial anti hemorrhagic gauze and preparation method thereof, be by hospital gauze after special antibacterial finishing agent is processed, the cotton of gauze, flaxen fiber strong bonded antibacterial finishing agent component, thus make hospital gauze there is antibacterial, hemostasis, antiinflammatory, the pain of releiving, promote the function of wound healing.
background technologymedical absorbent cotton/gauze is very conventional in medical care precess, is generally sterile gauze, be used for drain, leak stopping, cover or bind up a wound, gauze itself does not have any antibacterial, agglutinant performance.Although antibiotic use has reduced the incidence rate of wound infection, but still there is some patients' wound that acute or chronic infection can occur, cause healing delay, increased patient's misery.Can be antibacterial if the gauze of wound is processed in wrapping, hemostasis, alleviating pain, promotion healing, for wound restores, increased guarantee together so undoubtedly.The hospital gauze product that also there is no on the market at present this performance, so we think and be necessary to invent a kind of antibacterial anti hemorrhagic gauze, has antibiotic and sterilizing, the slow pain of hemostasis, ventilative comfortable, natural non-stimulated, the feature that promotes wound healing.
summary of the inventionthe invention provides a kind of antibacterial anti hemorrhagic gauze and preparation method thereof, main points are to select suitable antibacterial finishing agent, and hospital gauze is carried out to antibacterial preliminary finish, by dipping, low temperature drying, wind, are drenched production technology and are prepared from.The formula following (component and percentage by weight %) of antibacterial finishing agent: Chitosan 6-15, Radix Notoginseng 2-5, double-chain quaternary ammonium salt 2-6, citric acid 0.5-2, soft water add to 100.
Chitosan is alkaline polysaccharide unique in natural polysaccharide, has good biocompatibility and degradability, has collagen and Plant fiber's function simultaneously, has the effect of convergence wound; It has very strong affinity to human body cell, can not produce rejection, and skin is not stimulated, safe; It promotes the migration of interior leukin and macrophage, bring out fibroblast and produce the interleukin 8 (IL-8) with vascular proliferation effect, promote the formation of collagen molecules, accelerate the secretion of III collagen type, thereby promoted the formation of granulation tissue and epithelial tissue, promote wound healing and reduce cicatrix, owing to having absorbed bradykinin, thereby wound pain being had to the effect of well releiving.In addition, Chitosan also has bacteriostasis, and its principle may be that the negative charge on its positive charge and microbial cell film surface produces association, has changed the permeability of microbial cell film, thereby causes that microbial cell is dead.
The styptic activity composition of Radix Notoginseng is mainly Radix Notoginseng propylhomoserin, arasaponin etc.Radix Notoginseng propylhomoserin, by increasing thrombin amount in blood, shrinks local vascular and promotes blood coagulation with increase platelet counts, and arasaponin is by promoting fibrinolysis, and antiplatelet aggregation prevents thrombosis.Electron microscope observation discovery, Radix Notoginseng injection can make the platelet of experiment in vitro Cavia porcellus stretch pseudopodium, distortion, assemble, and make platelet membrane destroy and be partly dissolved, produce the secretory reactions such as the de-granule of platelet, thereby induced platelet discharges ADP, zymoplastin III and Ca
2+deng styptic activity material, performance anastalsis.
Double-chain quaternary ammonium salt is positively charged in water, can be adsorbed on microorganism surface and form micelle, and progressively infiltrate cytoplasmic lipoid layer and protein layer, thereby change after birth permeability, cellular content is exosmosed, cause microbial death, stronger to the killing action of the pathogenic bacterium such as fungus.
Citric acid, as cross-linking agent, makes active component be combined securely with cotton fibriia, guarantees its performance long-acting.
Preparation technology of the present invention is:
(1) preparation of antibacterial finishing agent: by proportioning, described component Chitosan, double-chain quaternary ammonium salt and citric acid are added in soft water, stir, emulsifying 20min; By proportioning, described component Radix Notoginseng is pulverized and added in retort, soft water adds to 100, stirs; Filter after purification, subpackage is standby;
(2) hospital gauze is immersed in above-mentioned antibacterial finishing agent to bath raio 1:10,37 ℃ of bath temperatures, stirring and evenly mixing, standing 10min;
(3) hospital gauze after dipping is carried out to low temperature drying, wind drenches dry; (4) repeat 1 (2), (3) step, the hospital gauze after antibacterial preliminary finish is sent into production line, flow-wraps.
The invention has the beneficial effects as follows: (1) high-efficiency antimicrobial, the slow pain of hemostasis; (2) ventilative comfortable, do not stimulate, have no side effect; (3) preparation technology is simple; (4) promote wound healing, prevent tissue adhesion; (5) be applicable to the wrapping nursing of surgical operation, burn and scald traumatology and traumatic surface.
the specific embodimentbelow in conjunction with embodiment, the present invention is described in further detail:
1, according to following table institute column data (percentage by weight %) and affiliated step thereof, carry out the configuration of antibacterial submissive liquid:
Formula one:
Chitosan 9-15, Radix Notoginseng 3-5, double-chain quaternary ammonium salt 4-6, citric acid 1-2, soft water adds to 100.
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Formula two:
Chitosan 6-15, Radix Notoginseng 2-5, double-chain quaternary ammonium salt 2-6, citric acid 0.5-2, soft water adds to 100.
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Formula three:
Chitosan 6-12, Radix Notoginseng 2-4, double-chain quaternary ammonium salt 2-5, citric acid 0.5-1, soft water adds to 100.
2, antibacterial preliminary finish:
(1) hospital gauze is immersed in above-mentioned antibacterial finishing agent to bath raio 1:10,37 ℃ of bath temperatures, stirring and evenly mixing, standing 10min;
(2) hospital gauze after dipping is carried out to low temperature drying, wind drenches dry;
(3) repeat 1 (1), (2) step, the hospital gauze after antibacterial preliminary finish is sent into production line, flow-wraps.
Claims (2)
1. antibacterial anti hemorrhagic gauze and preparation method thereof, is characterized in that the formula following (component and percentage by weight %) of antibacterial finishing agent: Chitosan 6-15, Radix Notoginseng 2-5, double-chain quaternary ammonium salt 2-6, citric acid 0.5-2, soft water adds to 100.
2. antibacterial anti hemorrhagic gauze according to claim 1 and preparation method thereof, it is characterized in that preparation technology is as follows: the preparation of (1) antibacterial finishing agent: by proportioning, described component Chitosan, double-chain quaternary ammonium salt and citric acid are added in soft water, stir, emulsifying 20min; By proportioning, described component Radix Notoginseng is pulverized and added in retort, soft water adds to 100, stirs; Filter after purification, subpackage is standby; (2) hospital gauze is immersed in above-mentioned antibacterial finishing agent to bath raio 1:10,37 ℃ of bath temperatures, stirring and evenly mixing, standing 10min; (3) hospital gauze after dipping is carried out to low temperature drying, wind drenches dry; (4) repeat 1 (2), (3) step, the hospital gauze after antibacterial preliminary finish is sent into production line, flow-wraps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210354248.9A CN103656735A (en) | 2012-09-21 | 2012-09-21 | Antibacterial hemostatic gauze and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210354248.9A CN103656735A (en) | 2012-09-21 | 2012-09-21 | Antibacterial hemostatic gauze and preparation method thereof |
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| CN103656735A true CN103656735A (en) | 2014-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210354248.9A Pending CN103656735A (en) | 2012-09-21 | 2012-09-21 | Antibacterial hemostatic gauze and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106835699A (en) * | 2017-02-07 | 2017-06-13 | 广东泰宝医疗器械技术研究院有限公司 | A kind of antibacterial hemostatic gauze and preparation method thereof |
| CN108939130A (en) * | 2017-05-21 | 2018-12-07 | 衢州玛济克医疗科技有限公司 | A kind of bedsore medical dressing and its production method |
| CN113073469A (en) * | 2021-03-10 | 2021-07-06 | 浙江大学 | Preparation method of medical antibacterial gauze |
-
2012
- 2012-09-21 CN CN201210354248.9A patent/CN103656735A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106835699A (en) * | 2017-02-07 | 2017-06-13 | 广东泰宝医疗器械技术研究院有限公司 | A kind of antibacterial hemostatic gauze and preparation method thereof |
| CN108939130A (en) * | 2017-05-21 | 2018-12-07 | 衢州玛济克医疗科技有限公司 | A kind of bedsore medical dressing and its production method |
| CN113073469A (en) * | 2021-03-10 | 2021-07-06 | 浙江大学 | Preparation method of medical antibacterial gauze |
| CN113073469B (en) * | 2021-03-10 | 2021-12-28 | 浙江大学 | Preparation method of medical antibacterial gauze |
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Application publication date: 20140326 |