CN104474573A - Biological mask and preparation method thereof - Google Patents
Biological mask and preparation method thereof Download PDFInfo
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- CN104474573A CN104474573A CN201410694548.0A CN201410694548A CN104474573A CN 104474573 A CN104474573 A CN 104474573A CN 201410694548 A CN201410694548 A CN 201410694548A CN 104474573 A CN104474573 A CN 104474573A
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Abstract
The invention discloses a biological mask. The biological mask is of a wet-type membrane and a dry-type membrane, wherein the wet-type membrane is prepared by infiltrating a chitosan non-woven membrane with a wet-type biological solution, and the wet-type biological solution is prepared from pure collagen concentrate, a plant essential oil disinfection solution, glycerol, chitosan powder and potassium sorbate; the dry-type membrane is prepared by infiltrating a chitosan non-woven membrane with a dry-type biological solution and carrying out dehydration, and the dry-type biological solution is prepared from pure collagen concentrate, the plant essential oil disinfection solution and the potassium sorbate; so that the biological mask does not have antigenicity, is good in flexibility, is capable of inducing regeneration of autologous skin, has the corresponding sterilization and disinfection effects and moisture retention function needed in the treatment process and is adapted to irregular wound surfaces.
Description
Technical field
The present invention relates to biological medicine and materials science field, particularly relate to a kind of biological deposited film and preparation method.
Background technology
Skin damage is recurrent thing, if can not get abundant treatment, the lighter leaves over spot after may curing, and serious may causing causes bacteriological infection to cause the serious diseases such as septicemia, even threat to life.
The market various deposited film that different materials is made is treated wound.If gelfoam is the hemostasis absorbent dressing used the earliest, but it guides Growth of Cells performance not as collagen.Other are as polysaccharide, and the class materials such as hyaluronic acid have the function of Promote cell's growth, but along with consumption increase, have the effect being suppressed to fibroblast growth, polyurethane, terylene, nylon, silicone rubber etc. are bio-inert material, do not degrade, can not physiological metabolism be carried out, outer dressing can only be used as.The biodegradation materials such as second lactide, degradable, can metabolism, if but its molecular weight is little, insufficient strength, molecular weight disaster is water-soluble, occurs degraded during dissolving, affect the mechanical strength of material, and the product after its degraded makes its surrounding tissue acidity improve, and occurs aseptic inflammation.
The humidity that the growth needs of skin is certain, clinical trauma care commonly use sterile gauze cover incrustation after wound surface, but gauze can not degraded and absorbed, also absorbs moisture, can not induced skin regeneration and restoration and boning with wound surface, bring very large misery to patient during removing gauze; Although existing market has many moist dressings, but the richness in nutrition that the risk produced is liquid causes the growth of antibacterial, due to the impact of environment and the sterilizing of dressing is insufficient or material does not have sterilizing function so that wound surface to pollute and bacterial infection, impact treatment even causes serious harm, and adopts chemosterilant easily to produce certain harm to human body.
The dressing preparation process of various biomaterial all relates to the aseptic controlling problem of product, because the richness in nutrition of material and the cycle of production generally need many days, even if make the breeding of also unavoidable antibacterial in an aseptic environment, so that cause product microbiological contamination or endotoxin to exceed standard, although there are many sterilization methods, but major part is all adopt chemical method, although reach the object of sterilization, chemosterilant exists the potential harm to human body.
Summary of the invention
The object of the present invention is to provide a kind of biological deposited film and preparation method, there is cytothesis effect, no antigen, preferably human body skin wound surface suitability, and the corresponding disinfection effect had required for therapeutic process and moisture-keeping functions, various wound surface can be adapted to.
In order to achieve the above object, technical scheme provided by the invention is: a kind of biological deposited film, comprise wet type film and drying type film, described wet type film infiltrates chitosan non-woven membrane by wet type biological raw liquor and makes, and described wet type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, glycerol, chitosan powder, potassium sorbate; Described drying type film dewaters after infiltrating chitosan non-woven membrane by drying type biological solution and makes, and described drying type biological solution is made up of wet type collagen protein stock solution, plants essential oil disinfectant solution, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1-1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1-5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20-25 international active unit, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain.
3) add in described collagen solution volume ratio be 10 ~ 25% glycerol, volume ratio be no more than 1% potassium sorbate and volume ratio be 0.1 ~ 10% plants essential oil disinfectant solution, pour side's planar disk into after the obtained biological solution of mixing;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) the chitosan non-woven membrane after infiltration is drained sealing after in rear loading lucifuge gas impermeable bag, preserve after irradiation sterilization.
The preparation of described drying type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1-1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1-5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20-25 international active unit, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain.
3) add in described collagen solution volume ratio be no more than 1% potassium sorbate and volume ratio be 0.1 ~ 10% plants essential oil disinfectant solution, after mixing, obtained collagen protein stock solution, pours side's planar disk into by collagen protein stock solution;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) after chitosan non-woven membrane after infiltration being drained lyophilizing again, dehydration loads sealing after in lucifuge gas impermeable bag again, preserves after irradiation sterilization.
The invention has the beneficial effects as follows: the present invention adopts chitosan non-woven membrane not only can play the repair of chitosan to damaged skin, and a carrier can be provided for other liquid substances; Add chitosan powder and not only play repair to skin, and thickening power can be played to solution, reach the sliminess that solution is certain; Plants essential oil disinfectant is added in manufacturing process, give full play to the disinfective action of plants essential oil, make the growth that effectively can prevent antibacterial in the preparation process of product and use procedure, avoid product microbiological contamination and endotoxic severe overweight, relative chemical disinfectant, has better safety and effectiveness.Use wet type film to think that the wound repair initial stage provides nutrient substance and sterilization at the wound repair initial stage, use drying type film to eliminate cicatrix better to repair wound in later stages of wound repair.
This product has cytothesis effect, no antigen, preferably human body skin wound surface suitability, corresponding disinfection effect required for therapeutic process and moisture-keeping functions, can adapt to various wound surface.
Detailed description of the invention
Embodiment 1
A kind of biological deposited film, comprise wet type film and drying type film, described wet type film infiltrates chitosan non-woven membrane by wet type biological solution and makes, and described wet type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, glycerol, chitosan powder, potassium sorbate; Described drying type film dewaters after infiltrating chitosan non-woven membrane by drying type biological solution and makes, and described drying type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) add in described collagen solution volume ratio be 10% glycerol, volume ratio be 0.5 potassium sorbate and volume ratio be 0.1% plants essential oil disinfectant solution, pour side's planar disk into after the obtained collagen protein stock solution of mixing;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) the chitosan non-woven membrane after infiltration is drained sealing after in rear loading lucifuge gas impermeable bag, preserve after irradiation sterilization.
The preparation of described drying type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) in described collagen solution, add volume ratio 0.5% potassium sorbate and volume ratio are 0.1% plants essential oil disinfectant solution, and after mixing, obtained collagen protein stock solution, pours side's planar disk into by collagen protein stock solution;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) after chitosan non-woven membrane after infiltration being drained lyophilizing again, dehydration loads sealing after in lucifuge gas impermeable bag again, preserves after irradiation sterilization.
Embodiment 2
A kind of biological deposited film, comprise wet type film and drying type film, described wet type film infiltrates chitosan non-woven membrane by wet type biological solution and makes, and described wet type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, glycerol, chitosan powder, potassium sorbate; Described drying type film dewaters after infiltrating chitosan non-woven membrane by drying type biological solution and makes, and described drying type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 25 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) in described collagen solution, add that volume ratio is the glycerol of 25%, the potassium sorbate of volume ratio 0.1% and volume ratio be 10% plants essential oil disinfectant solution, after the obtained collagen protein stock solution of mixing, pour side's planar disk into;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) the chitosan non-woven membrane after infiltration is drained sealing after in rear loading lucifuge gas impermeable bag, preserve after irradiation sterilization.
The preparation of described drying type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 25 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) add in described collagen solution volume ratio be 0.1% potassium sorbate and volume ratio be 10% plants essential oil disinfectant solution, after mixing, obtained collagen protein stock solution, pours side's planar disk into by collagen protein stock solution;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) after chitosan non-woven membrane after infiltration being drained lyophilizing again, dehydration loads sealing after in lucifuge gas impermeable bag again, preserves after irradiation sterilization.
Embodiment 3
A kind of biological deposited film, comprise wet type film and drying type film, described wet type film infiltrates chitosan non-woven membrane by wet type biological solution and makes, and described wet type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, glycerol, chitosan powder, potassium sorbate; Described drying type film dewaters after infiltrating chitosan non-woven membrane by drying type biological solution and makes, and described drying type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, potassium sorbate.
The preparation of described wet type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 3:2, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 3%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 22 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) add in described collagen solution volume ratio be 15% glycerol, volume ratio be 0.9% potassium sorbate and volume ratio be 0.6% plants essential oil disinfectant solution, pour side's planar disk into after the obtained collagen protein stock solution of mixing;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) the chitosan non-woven membrane after infiltration is drained sealing after in rear loading lucifuge gas impermeable bag, preserve after irradiation sterilization.
The preparation of described drying type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 3:2, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of described collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 3%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 22 international active units, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) in described collagen solution, add volume ratio 0.9% potassium sorbate and volume ratio are 0.6% plants essential oil disinfectant solution, and after mixing, obtained collagen protein stock solution, pours side's planar disk into by collagen protein stock solution;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) after chitosan non-woven membrane after infiltration being drained lyophilizing again, dehydration loads sealing after in lucifuge gas impermeable bag again, preserves after irradiation sterilization.
One of material in the present invention collagen protein stock solution, can divide by irritation cell, is conducive to cell and creeps to wound location repair deficiency, and can be suppressed to fibroblast growth, without the formation of cicatrix; Due to the biotic component identical with human body cell interstitial, non-stimulated to human body, allergy and atopic reaction can not be produced; This material has biodegradability, and collagen protein degradable is polypeptide, can be absorbed by the body, and can maintain the long period, be conducive to wound healing in wound, saves the nursing time, alleviates misery and the financial burden of patient.Collagen protein degradable is by aminoacid thus absorbed by human body.
The chitosan powder of the material two in the present invention, this material has good activating cell effect, enhances metabolism, and repairs the effect of old and feeble mutant; Non-stimulated to human body, allergy and atopic reaction can not be produced; This material has biodegradability, can be absorbed by the body, and can maintain the long period, be conducive to wound healing in wound; Certain thickening power is also had concurrently in this external product.
Three plants essential oil disinfectant solution of the material in the present invention, be made up of plants essential oil and a small amount of ethanol, plants essential oil is Chinese conventional Chinese medicine, the therapeutical effect of tool skin, and have effect of antisepsis and sterilization and antiinflammatory, adopt plants essential oil can avoid the harm because other disinfectant may produce human body as disinfectant, and there is the suitable abnormal smells from the patient of human body and antalgesic-antipruritic, increase the comfort level of the process for the treatment of.Plants essential oil and the rear solution formed of ethanol mixing can make plants essential oil disinfectant solution mix in biological solution, to prevent the microbiological contamination of biological solution.
The glycerol of the material four in the present invention, except having moisturizing, humectation function, also has the special efficacies such as high activity, antioxidation, short alcoholization.
In the present invention, the potassium sorbate of material five is mainly to the anti-corrosion function of the various raw materials that product adopts.
The chitosan non-woven membrane of the material six in the present invention, this material has good activating cell effect, enhance metabolism, repair the effect of old and feeble mutant, the benefit adopting chitosan non-woven membrane maximum not only to play the repair of chitosan to damaged skin, and can provide a carrier for solution mass.
To sum up to the description of various material function; its design advantage shows as; make use of various material cleverly to treat impaired skin wound from different perspectives; and the physical aspect that make use of various material is relied on mutually; stick damaged skin surface carry out protecting and repairing to facilitate; promote that skin increases, finally make wound surface be fully recovered.
The present invention can have plurality of specifications size as required, can be suitable for the injury in treating that partes corporis humani divides epidermis; Also the nursing of skin surface can be comprised.
Preparation of the present invention should adopt aseptically to be carried out, and because manufacturing process adopts material to get pure method, may affect the content of plants essential oil disinfectant, can be kept resistance bacterium, the bacteriostasis of material by the content constantly supplementing plants essential oil disinfectant.
Plants essential oil of the present invention comprises Herba Pogostemonis essential oil, tea tree ethereal oil, clove oil, eucalyptus quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, Peppermint essential oil.
Material of the present invention is commercially, for ensureing product quality, the specification that should purity be adopted as far as possible high.Processing technology is collagen protein extraction process and common aseptic deposited film manufacturing process.
Claims (3)
1. a biology applies film, it is characterized in that: comprise wet type film and drying type film, described wet type film infiltrates chitosan non-woven membrane by wet type biological solution and makes, and described wet type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, glycerol, chitosan powder, potassium sorbate; Described drying type film dewaters after infiltrating chitosan non-woven membrane by drying type biological solution and makes, and described drying type biological solution is made up of collagen protein stock solution, plants essential oil disinfectant solution, potassium sorbate.
2. a kind of biology applies the preparation method of film according to claim 1, it is characterized in that, the preparation of described wet type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1-1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%;
2) preparation of collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1-5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20-25 international active unit, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) add in described collagen solution volume ratio be 10 ~ 25% glycerol, volume ratio be no more than 1% potassium sorbate and volume ratio be 0.1 ~ 10% plants essential oil disinfectant solution, pour side's planar disk into after the obtained biological solution of mixing;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) the chitosan non-woven membrane after infiltration is drained sealing after in rear loading lucifuge gas impermeable bag, preserve after irradiation sterilization.
3. a kind of biology applies the preparation method of film according to claim 1, it is characterized in that, the preparation of described drying type film comprises the following steps:
1) plants essential oil and ethanol are mixed in the ratio of 2:1-1:1, then adding weight ratio is obtain thick plants essential oil disinfectant solution after the chitosan powder mixing of 1%-5%; ,
2) preparation of collagen protein: get mammiferous tendon, remove oils and fats, with plants essential oil medicining liquid dipping sterilization, liquid is drained after taking-up, tendon is made to possess certain plants essential oil disinfectant solution, then tendon being soaked in percent by volume is in the acid solution of 1-5%, and add pepsin solution, the pepsin in every milliliter of acid solution is made to be 20-25 international active unit, stirring and evenly mixing, at room temperature being dipped to solution viscosity is 500-1000cp (centipoise), filters high concentration collagen solution of purifying to obtain;
3) add in described collagen solution volume ratio be no more than 1% potassium sorbate and volume ratio be 0.1 ~ 10% plants essential oil disinfectant solution, after mixing, obtained collagen protein stock solution, pours side's planar disk into by collagen protein stock solution;
4) chitosan non-woven membrane is infiltrated by applying in dish after required size cutting;
5) after chitosan non-woven membrane after infiltration being drained lyophilizing again, dehydration loads sealing after in lucifuge gas impermeable bag again, preserves after irradiation sterilization.
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| CN201410694548.0A CN104474573B (en) | 2014-11-27 | 2014-11-27 | Biological mask and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511977A (en) * | 2016-11-04 | 2017-03-22 | 广州赛莱拉干细胞科技股份有限公司 | Collagen dressing |
| CN107184412A (en) * | 2017-04-14 | 2017-09-22 | 绍兴金石生物工程有限公司 | The preparation method that liquid is repaired in a kind of moisturizing |
| CN108404194A (en) * | 2018-04-20 | 2018-08-17 | 朱清 | A kind of preparation method of quick-acting haemostatic powder gauze |
| CN112263488A (en) * | 2020-11-05 | 2021-01-26 | 防城港盛农磷化有限公司 | Preparation method of collagen mask |
| CN113730641A (en) * | 2021-09-28 | 2021-12-03 | 珠海金标生物科技有限公司 | Slow-release antibacterial dressing and preparation method thereof |
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| CN101791425A (en) * | 2010-03-30 | 2010-08-04 | 赵雪林 | Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof |
| CN102643554A (en) * | 2012-05-08 | 2012-08-22 | 福州大学 | Edible fishskin collagen antibiosis membrane and preparing method thereof |
| CN103749563A (en) * | 2011-12-30 | 2014-04-30 | 青岛艾华隆生物科技有限公司 | Plant essential oil composition disinfectant |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101791425A (en) * | 2010-03-30 | 2010-08-04 | 赵雪林 | Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof |
| CN103749563A (en) * | 2011-12-30 | 2014-04-30 | 青岛艾华隆生物科技有限公司 | Plant essential oil composition disinfectant |
| CN102643554A (en) * | 2012-05-08 | 2012-08-22 | 福州大学 | Edible fishskin collagen antibiosis membrane and preparing method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511977A (en) * | 2016-11-04 | 2017-03-22 | 广州赛莱拉干细胞科技股份有限公司 | Collagen dressing |
| CN107184412A (en) * | 2017-04-14 | 2017-09-22 | 绍兴金石生物工程有限公司 | The preparation method that liquid is repaired in a kind of moisturizing |
| CN108404194A (en) * | 2018-04-20 | 2018-08-17 | 朱清 | A kind of preparation method of quick-acting haemostatic powder gauze |
| CN112263488A (en) * | 2020-11-05 | 2021-01-26 | 防城港盛农磷化有限公司 | Preparation method of collagen mask |
| CN113730641A (en) * | 2021-09-28 | 2021-12-03 | 珠海金标生物科技有限公司 | Slow-release antibacterial dressing and preparation method thereof |
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| CN104474573B (en) | 2017-02-22 |
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Effective date of registration: 20210702 Address after: 4th floor, building 21, No.1, Lane 618, Dingyuan Road, Songjiang District, Shanghai Patentee after: Zengguang Bioengineering (Shanghai) Co.,Ltd. Address before: 312000 Doumen industrial community, Qisheng road crossing, Paojiang New District, Shaoxing City, Zhejiang Province Patentee before: SHAOXING KING STONE BIOENGINEERING Co.,Ltd. |