CN103656353B - A kind of pharmaceutical composition and application thereof for the treatment of pulmonary abscess - Google Patents
A kind of pharmaceutical composition and application thereof for the treatment of pulmonary abscess Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of pulmonary abscess, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 30-46 part, Folium Bambusae 22-34 part, Semen Persicae 22-34 part, Radix Scutellariae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 10-20 part, Semen Coicis 30-46 part, Semen phaseoli radiati 80-160 part.This pharmaceutical composition of the present invention agrees with pulmonary abscess pathogenesis, can obviously alleviate patients symptomatic and sign, thus improves pulmonary abscess treatment total effective rate.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of pharmaceutical composition and application thereof for the treatment of pulmonary abscess.
Background technology
Pulmonary abscess is the lung tissue purulent lesion caused by Different types of etiopathogenises.Early stage is suppurative inflammation, then downright bad formation abscess.Multiplely be born in the prime of life, man is more than female.According to theory of Chinese medical science, pulmonary abscess belongs to Chinese medicine " lung abscess ", is by wind heat fire-toxin, stops up stagnant lungs, and steaming liquid is expectorant, the hot blood-retention stasis of blood, phlegm and blood stasis, and blood loses meat corruption, pus infections.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition and application for the treatment of pulmonary abscess.This pharmaceutical composition, as secret prescription handed down in the family from generation to generation, agrees with pulmonary abscess pathogenesis, obviously can alleviate patients symptomatic, is a kind of specific drug for the treatment of pulmonary abscess.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for pulmonary abscess, it is prepared from by the traditional Chinese medicinal material raw materials comprising following weight portion: Herba Houttuyniae 30-46 part, Folium Bambusae 22-34 part, Semen Persicae 22-34 part, Radix Scutellariae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 10-20 part, Semen Coicis 30-46 part, Semen phaseoli radiati 80-160 part.
Preferably, the pharmaceutical composition for the treatment of pulmonary abscess as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 38-42 part, Folium Bambusae 26-30 part, Semen Persicae 26-30 part, Radix Scutellariae 13-17 part, Pericarpium Citri Reticulatae 13-17 part, Radix Glycyrrhizae 13-17 part, Semen Coicis 38-42 part, Semen phaseoli radiati 100-140 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition for the treatment of pulmonary abscess as above is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 40 parts, 28 parts, Folium Bambusae, 28 parts, Semen Persicae, Radix Scutellariae 15 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Radix Glycyrrhizae, Semen Coicis 40 parts, 120 parts, Semen phaseoli radiati.
Found by experimental study, pharmaceutical composition of the present invention is for the symptom and the sign effect highly significant that improve pulmonary abscess patient.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment pulmonary abscess.
Preferably, the medicine described in when pharmacy is applied is oral formulations.Further preferably, described oral formulations comprises oral liquid, tablet, capsule, granule.
The preparation method of the pharmaceutical composition that the present invention relates to comprises the steps: that (1) gets Herba Houttuyniae 30-46 part of recipe quantity, Folium Bambusae 22-34 part, Semen Persicae 22-34 part, Radix Scutellariae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 10-20 part, Semen Coicis 30-46 part and Semen phaseoli radiati 80-160 part, clean roguing, dry, pulverize; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; (3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
According to Chinese medicine Historical Data Data About, pharmacologically active and the source of the traditional Chinese medicinal material raw materials that the present invention adopts are as follows:
Herba Houttuyniae: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Herba Houttuyniae selects the drying water upper part of Saururaceae herbaceos perennial Herba Houttuyniae.Folium Bambusae: clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid.Control calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea tells nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.Folium Bambusae selects the dried leaves of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Semen Persicae: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Semen Persicae selects the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.The dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi selected by Radix Scutellariae.Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Pericarpium Citri Reticulatae selects the dry mature skin into rutaceae orange and variety thereof.Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Radix Glycyrrhizae is selected as dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..Semen Coicis: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.Cure mainly edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.Select the dry mature kernal of grass Semen Coicis (Coix lachryma-jobi L).Semen phaseoli radiati: heat clearing away; Relieve summer heat; Diuretic; Removing toxic substances.Summer-heat excessive thirst; Cold, fever; Cholera is vomited and diarrhoea; Expectorant asthma of heat type is breathed heavily; Headache conjunctival congestion; Aphtha of the mouth and tongue; Edema oliguria; Skin infection carbuncle; Rubella erysipelas; Medicine and alimentary toxicosis.The seed of leguminous plant Semen phaseoli radiati selected by Semen phaseoli radiati.
This pharmaceutical composition of the present invention agrees with pulmonary abscess pathogenesis, can obviously alleviate patients symptomatic and sign, thus improves pulmonary abscess treatment cure rate and total effective rate.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: Herba Houttuyniae 40 parts, 28 parts, Folium Bambusae, 28 parts, Semen Persicae, Radix Scutellariae 15 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Radix Glycyrrhizae, Semen Coicis 40 parts, 120 parts, Semen phaseoli radiati.
Preparation technology: (1) gets the Herba Houttuyniae of recipe quantity, Folium Bambusae, Semen Persicae, Radix Scutellariae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Semen Coicis and Semen phaseoli radiati, cleans roguing, dries, and pulverizes; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; (3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
The preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: Herba Houttuyniae 45 parts, 33 parts, Folium Bambusae, 25 parts, Semen Persicae, Radix Scutellariae 10 parts, Pericarpium Citri Reticulatae 20 parts, 15 parts, Radix Glycyrrhizae, Semen Coicis 46 parts, 150 parts, Semen phaseoli radiati.
Preparation technology: (1) gets the Herba Houttuyniae of recipe quantity, Folium Bambusae, Semen Persicae, Radix Scutellariae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Semen Coicis and Semen phaseoli radiati, cleans roguing, dries, and pulverizes; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; (3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
The preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: Herba Houttuyniae 36 parts, 22 parts, Folium Bambusae, 34 parts, Semen Persicae, Radix Scutellariae 18 parts, Pericarpium Citri Reticulatae 10 parts, 20 parts, Radix Glycyrrhizae, Semen Coicis 32 parts, 100 parts, Semen phaseoli radiati.
Preparation technology: (1) gets the Herba Houttuyniae of recipe quantity, Folium Bambusae, Semen Persicae, Radix Scutellariae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Semen Coicis and Semen phaseoli radiati, cleans roguing, dries, and pulverizes; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; (3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Embodiment 4 Chinese medicine is to the effectiveness study of pulmonary abscess patient
The diagnostic criteria of pulmonary abscess patient: 1) patient's onset is comparatively anxious, fever with aversion to cold, body temperature raises, and cough chest pain, coughs and tell stench purulent sputum, dry mouth and throat, rapid breathing, red tongue, bitter yellow greasy, slippery and rapid pulse.2) lung abscess position respiratory murmur lowers, audible and moist rales.3) blood routine examination: Leukocyte Counts and neutrophilic granulocyte obviously raise.4) chest x-ray chest film inspection, visible pulmonary pus infections.
Through the 51 routine pulmonary abscess patients that above-mentioned diagnostic criteria is made a definite diagnosis, be divided into two groups at random, Chinese drug-treated group 26 example, male 17 example, women 9 example, minimum 30 years old of age, maximum 72 years old, average 49 years old; The longest 38d of the course of disease, the shortest 3d, average 10d.Matched group 25 example, male 16 example, women 9 example; Minimum 28 years old of age, maximum 69 years old, average 47 years old; The longest 32d of the course of disease, the shortest 4d of the course of disease, average 9d.Two groups of ages, sex, symptom, sign, the equal no significant difference of the course of disease (
p>0.05), there is comparability.Chinese medicine oral liquid prepared by the Chinese drug-treated group patient oral embodiment of the present invention 1 method, morning and evening every day is each once, each 40mL.Matched group vein gives enough penicillins.Two groups of patients all give relative medicine treatment two weeks.Criterion of therapeutical effect is as follows:
Cure: symptom and sign disappear, x-ray checks that focus absorbs, and other lab testings recover normal;
Effective: symptom and sign disappear substantially, x-ray checks that focus major part absorbs, and other lab testings are normal;
Effective: symptom and sign obviously alleviate, x-ray checks that focal part absorbs, and other lab testing parts are recovered;
Invalid: symptom and sign have no improvement.
After treatment, two groups of concrete result of the tests of Clinical efficacy comparison are in table 1.
The Clinical efficacy comparison of table 1 Chinese drug-treated group and matched group
The present invention treats the evident in efficacy of pulmonary abscess as can be seen from Table 1.
Claims (4)
1. treat a pharmaceutical composition for pulmonary abscess, it is characterized in that described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 40 parts, 28 parts, Folium Bambusae, 28 parts, Semen Persicae, Radix Scutellariae 15 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Radix Glycyrrhizae, Semen Coicis 40 parts, 120 parts, Semen phaseoli radiati.
2. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment pulmonary abscess.
3. application according to claim 2, is characterized in that: described medicine is oral formulations.
4. application according to claim 3, is characterized in that: described oral formulations is oral liquid, tablet, capsule or granule.
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| CN104225474A (en) * | 2014-09-19 | 2014-12-24 | 宋秀花 | Traditional Chinese medicine for treating chronic lung abscess |
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| CN102716375A (en) * | 2012-06-18 | 2012-10-10 | 天津开发区经经新优技术产品开发有限公司 | Chinese patent drug and traditional Chinese medicine decoction capable of treating lung abscess effectively |
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| Title |
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| 洪广祥教授治疗肺痈经验;陈建建等;《广西中医药》;20001231;第23卷(第6期);第28，31页 * |
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