CN103623065B - Medicine composition for treating influenza - Google Patents
Medicine composition for treating influenza Download PDFInfo
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- CN103623065B CN103623065B CN201310655223.7A CN201310655223A CN103623065B CN 103623065 B CN103623065 B CN 103623065B CN 201310655223 A CN201310655223 A CN 201310655223A CN 103623065 B CN103623065 B CN 103623065B
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Abstract
The invention discloses a medicine for treating influenza and belongs to a Tibetan medicine composition. The medicine is prepared from the following components according to a certain weight ratio: myrobalan, false Chinese swertia herb, herpetospermum pedunculosum seeds, hypecoum erectum, flos pyrethri tatsienensis, liquorice, chrysosplenium, holarrhena antidysenteriaca and calculus bovis factitius. The medicine can be prepared into common oral dosage forms by adding a proper amount of pharmaceutically acceptable auxiliary materials. The medicine has the effects of clearing away heat and toxin, diminishing inflammation and relieving a cough, is used for treating fever of the influenza, has a good effect of treating symptoms such as headache and cough, ache in the whole body and inflammation-induced fever, does not have a toxic or side effect and is suitable for popularization.
Description
Technical field
The present invention relates to one and treat grippal medicine, be specifically related to one and treat grippal Tibetan medicinal composition, belong to biomedicine technical field.
Background technology
Influenza, being called for short influenza, is a kind of Acute respiratory infectious disease caused by influenza virus.Influenza virus infection is strong, propagates fast, easily causes and be very popular, and can cause more serious symptom, as pneumonia or cardiopulmonary exhaustion etc. the patient of the more weak old man of immunity or child and some immune disorders.At present, the most side effect of Western medicine of prevention and therapy influenza is relatively large, and extensively easily produce drug resistance along with what apply, and vaccine only has preventive effect to known influenza virus sub-strain, invalid for the novel influenza produced by antigenic drift or antigenicity conversion.
Influenza belongs in Tibetanmedicine " pestilence " category, Tibetan medicine and pharmacology is the important component part of China's traditional medicine, in epidemic prevention and control, have accumulated rich experience for thousands of years, its understanding to epidemic disease, diagnosis, prevention, treatment etc. all have characteristic and the advantage of self distinctness.Prescription of the present invention proposes according to the summary of experience of to treat epidemic disease for many years, can not only heat clearing away antiviral, and have the effect improving human immunologic function, to bring down a fever antiinflammatory, alleviate upper airway symptoms and have more advantage than single antiviral drug treatment.
Summary of the invention
The object of this invention is to provide one and treat grippal pharmaceutical composition, the flu that the effective prevention and therapy of energy is caused by influenza virus.
The present invention is achieved by the following measures:
One treats grippal pharmaceutical composition; it is characterized in that being made up of the crude drug of following weight portion: Fructus Chebulae 100-120 part; Herba Swertiae bimaculatae 140-160 part; Herpetospermum caudigerum Wall. 30-50 part, Radix Hypecol Erecti 70-90 part, DAJIANJU 90-100 part; Radix Glycyrrhizae 50-70 part; Chrysosplenium nudicaule Bunge 40-60 part, seed of Cortex Holarrhenae Antidysentericae 40-60 part, artificial Calculus Bovis 3-8 part.
In said medicine, preferably, be made up of the crude drug of following weight portion: Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts, Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.
Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis, to obtain final product except artificial Calculus Bovis.
Pharmaceutical composition of the present invention, can add appropriate pharmaceutic adjuvant and make pharmaceutically conventional oral formulations further, as powder, pill, granule, capsule or tablet.
Inventor is in conjunction with Tibetan medicine and pharmacology theory, science have selected heat-clearing and toxic substances removing, pathogenic fire reducing sore-throat relieving, the medicine of antitussive analgesic efficacy, further by a large amount of experiments and use for many years, summed up the formula of resisiting influenza virus of the present invention, in this formula, each medicine material works in coordination with onset, have good effect to treatment influenza, each medical material effect is as follows:
Fructus Chebulae: bitter in the mouth, acid, puckery, property is put down, and return lung, large intestine channel, have astringing intestine to stop diarrhea to astringe the lung, effect of pathogenic fire reducing sore-throat relieving, be used for the treatment of chronic diarrhea chronic dysentery, proctoptosis of having blood in stool, the deficiency of the lung is breathed with cough, and chronic cough is more than, pharyngalgia hoarseness.
Herba Swertiae bimaculatae: bitter in the mouth, pungent, cold in nature, returns liver, the heart, stomach warp, has heat-clearing and toxic substances removing, dampness removing, effect of depressed liver-energy dispersing and function of gallbladder promoting, be used for the treatment of main acute hepatitis, chronic hepatitis, cholecystitis, cold, fever, laryngopharynx swelling and pain, gingival swelling and pain, urinary tract infection, gastroenteritis, dysentery, acute catarrhal conjunctivitis, oral aphthae in children etc.
Herpetospermum caudigerum Wall.: bitter in the mouth, cold in nature, have liver heat removing function of gallbladder promoting, spleen invigorating helps effect of fortune, cures mainly icteric infectious hepatitis, cholecystitis, dyspepsia etc.
Radix Hypecol Erecti: bitter in the mouth, pungent, cool in nature, returns lung, large intestine, Liver Channel, has effect of heat-clearing and toxic substances removing, antitussive pain relieving, cure mainly cold, fever, cough, laryngopharynx swelling and pain, liver-heat conjunctival congestion, hepatitis, cholecystitis, dysentery, arthralgia etc.
DAJIANJU: bitter in the mouth, cold in nature, there is dissipating blood stasis, pain relieving, hold back the effect of " yellow fluid ", be used for the treatment of grasserie, cerebral concussion, pestilence, temple pain and traumatic injury and warm skin infection etc.
Radix Glycyrrhizae: sweet in the mouth, property is put down, and returns spleen, stomach, lung meridian, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Chrysosplenium nudicaule Bunge: bitter in the mouth, cold in nature, there is clearing heat secreting bile, the effect under cathartic, be used for the treatment of gallbladder-heat disease, fever, headache, cholecystitis, the diseases such as cholelithiasis.
Seed of Cortex Holarrhenae Antidysentericae: bitter in the mouth, puckery, cold in nature, has heat clearing away, function of gallbladder promoting, the effect of antidiarrheal.Sick for red bar, liver-gallbladder disease, gastrointestinal calentura, diarrhoea, dysentery etc.
Artificial Calculus Bovis: sweet in the mouth, cool in nature, GUIXIN, Liver Channel, have and clear away heart-fire, and eliminating phlegm is had one's ideas straightened out, cool liver, endogenous wind stopping, effect of removing toxic substances, and for calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Formula of the present invention is unique, has effect of heat clearing away, removing toxic substances, antiinflammatory, cough-relieving, is used for the treatment of influenza heating, headache cough, malasia, and inflammation fever etc. are respond well, have no side effect, and are applicable to promoting.
Detailed description of the invention:
Below by specific embodiment, the present invention will be further elaborated, and following explanation is only to explain the present invention, does not limit its content.
Embodiment 1
Get Fructus Chebulae 100 parts, Herba Swertiae bimaculatae 140 parts, Herpetospermum caudigerum Wall. 30 parts, Radix Hypecol Erecti 70 parts, DAJIANJU 90 parts, 50 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 40 parts, seed of Cortex Holarrhenae Antidysentericae 40 parts, artificial Calculus Bovis 3 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis, to obtain final product except artificial Calculus Bovis.
Embodiment 2
Get Fructus Chebulae 120 parts, Herba Swertiae bimaculatae 160 parts, Herpetospermum caudigerum Wall. 50 parts, Radix Hypecol Erecti 90 parts, DAJIANJU 100 parts, 70 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 60 parts, seed of Cortex Holarrhenae Antidysentericae 60 parts, artificial Calculus Bovis 8 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis, to obtain final product except artificial Calculus Bovis.
Embodiment 3
Get Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts, Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis, to obtain final product except artificial Calculus Bovis.
Embodiment 4
Get Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts, Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis except artificial Calculus Bovis, and fine powder water pill, to obtain final product.
Embodiment 5
Get Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts, Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis except artificial Calculus Bovis, add dextrin, mannitol, stevioside mix homogeneously, and using 70% ethanol as wetting agent, stir and make soft material, extruding, granulate, airpillow-dry, granulate, to obtain final product.
Embodiment 6
Get Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts, Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae, Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.Above nine tastes, are ground into fine powder, mix homogeneously with artificial Calculus Bovis, add microcrystalline Cellulose except artificial Calculus Bovis, and dextrin mixes, and makes suitable soft material with 85% ethanol, and extruding is granulated, dry, granulate, then adds magnesium stearate, mix homogeneously, tabletting, to obtain final product.
Experimental example: treat grippal clinical observation on the therapeutic effect
1. diagnostic criteria
1.1 Western medicine diagnose standards
(1) the popular contact history of flu is had
(2) based on local symptom, General Symptoms can have or not obvious
1. local symptom sneeze, nasal obstruction, watery nasal discharge, sometimes cough, pharyngalgia, hoarseness, shed tears.
2. General Symptoms fever with aversion to cold, general malaise, headache and dizziness, extremity aching pain in waist and back.
1.2 traditional Chinese medical science influenza diagnostic criterias
(1) fever with chills, very then shivers with cold, nasal obstruction, head body severe pain, and flushed complexion, swallows red, cough etc.
(2) rapid pulse, body of the tongue is normal or red, white or yellow thin fur.
(3) fall ill hurried, symptom is similar, propagates fast, in popular.
2. inclusive criteria
1. Western medicine diagnose standard is met; 2. the diagnostic criteria of traditional Chinese medical science influenza is met; 3. fall ill person within 48 hours; 4. patient is in the know coordinates.
3. case selection
Observe case 100 example, be divided into two groups at random, carry out parallel control research.Test group 50 example, man 30 example, female 20 example; Age 18-65 one full year of life.Matched group 50 example, man 25 example, female 25 example; Age 18-60 one full year of life.Two groups of equal no difference of science of statistics in demographic characteristics, vital sign, the state of an illness and the order of severity, history of past illness, allergies, lab testing etc., have comparability.
4. dosage regimen
The obtained treatment flu pharmaceutical of the oral embodiment of test group experimenter 4, every day 3 times, each 2 balls, matched group experimenter gives SHUANGHUANGLIAN KELI, and (Harbin No.2 Traditional Chinese Pharmacetical Plant produces, lot number: 120136) 5g/ time, every day three times, take 3 days continuously, duration of test is forbidden adding the Pharmaceuticals with close with trial drug effect, if any the complication relevant with disease, all can anti symptom treatment, but test group and the harmony of matched group in drug combination kind and dosage will be noted.
5. observation index
According to disease clinical manifestation, related symptoms and sign scored and evaluated, body temperature by the classification of state of an illness weight, pulse, breathing, observing emphatically the onset time of Drug therapy heating, observing the Temperature changing of different time points, temperature recovery normal time etc.
According to appended disease scalar quantization scale, primary symptom "None" is 0 point, and " gently " is 2 points, " in " be 4 points, " weight " is 6 points; Time disease "None" of holding concurrently is 0 point, and " gently " is 1 point, " in " be 2 points, " weight " is 3 points.
Table 1 cold symptoms scalar quantization table
6. statistical procedures
Group data adopts χ
2inspection, utilizes SPSS13.0 statistical software to analyze.
7. efficacy assessment standard and result
7.1 efficacy assessment standards:
Syndrome integral × 100% before therapeutic index=(before treatment the rear syndrome integral of syndrome integral-treatment)/treatment.
Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces (therapeutic index) >=30%;
Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces (therapeutic index) <30%.
7.2 validity result:
Two groups of Clinical efficacy comparisons: treatment group total effective rate 92%, compare between matched group total effective rate 82%, two groups and have significant difference (P<0.05).The results are shown in Table 2.
Table 2 liang group Clinical efficacy comparison
Claims (4)
1.
one treats grippal pharmaceutical composition, it is characterized in that, is made up of the crude drug of following weight portion: Fructus Chebulae 110 parts, Herba Swertiae bimaculatae 150 parts; Herpetospermum caudigerum Wall. 40 parts, Radix Hypecol Erecti 80 parts, DAJIANJU 95 parts, 60 parts, Radix Glycyrrhizae; Chrysosplenium nudicaule Bunge 50 parts, seed of Cortex Holarrhenae Antidysentericae 50 parts, artificial Calculus Bovis 5 parts.
2. the grippal pharmaceutical composition for the treatment of according to claim 1, is characterized in that, adds appropriate pharmaceutic adjuvant and makes pharmaceutically conventional powder, pill, granule, capsule or tablet formulation.
3. a preparation method for the grippal pharmaceutical composition for the treatment of according to claim 1, is characterized in that, by crude drug proportioning in proportion, is ground into fine powder, mixs homogeneously with artificial Calculus Bovis, to obtain final product except artificial Calculus Bovis.
4. the preparation method of the grippal pharmaceutical composition for the treatment of according to claim 1; it is characterized in that; by crude drug proportioning in proportion; fine powder is ground into except artificial Calculus Bovis; mix homogeneously with artificial Calculus Bovis, then add appropriate pharmaceutic adjuvant and make pharmaceutically conventional powder, pill, granule, capsule or tablet formulation.
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| CN104258086A (en) * | 2014-10-22 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Tibetan medicine for curing influenza |
| CN104258085A (en) * | 2014-10-22 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Preparation method of Tibetan drug for treating influenza |
| CN106177290A (en) * | 2016-10-11 | 2016-12-07 | 张顺芹 | A kind of pharmaceutical composition treating summer-wet type upper respiratory tract infection |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1364488A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano thirteen ingredient Bonga aconite medicine powder and its preparing method |
| CN101647993A (en) * | 2009-07-20 | 2010-02-17 | 甘肃奇正藏药有限公司 | Medicament for treating flu and preparation and detection method thereof |
| CN103316086A (en) * | 2013-07-17 | 2013-09-25 | 宋永心 | Tibetan medicine for treating influenza and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1364488A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano thirteen ingredient Bonga aconite medicine powder and its preparing method |
| CN101647993A (en) * | 2009-07-20 | 2010-02-17 | 甘肃奇正藏药有限公司 | Medicament for treating flu and preparation and detection method thereof |
| CN103316086A (en) * | 2013-07-17 | 2013-09-25 | 宋永心 | Tibetan medicine for treating influenza and preparation method thereof |
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Granted publication date: 20150603 Termination date: 20191205 |