CN103588832B - 从常春藤叶中分离常春藤苷c及苷元的方法 - Google Patents
从常春藤叶中分离常春藤苷c及苷元的方法 Download PDFInfo
- Publication number
- CN103588832B CN103588832B CN201310618958.2A CN201310618958A CN103588832B CN 103588832 B CN103588832 B CN 103588832B CN 201310618958 A CN201310618958 A CN 201310618958A CN 103588832 B CN103588832 B CN 103588832B
- Authority
- CN
- China
- Prior art keywords
- hederacoside
- acid
- ethanol
- hydrolysis
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- RYHDIBJJJRNDSX-MCGLQMIESA-N Hederacoside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](OC(=O)[C@@]34[C@@H](CC(C)(C)CC3)C=3[C@@]([C@]5(C)CC[C@H]6[C@](C)(CO)[C@@H](O[C@H]7[C@@H]([C@@H](O)[C@@H](O)CO7)O[C@H]7[C@@H]([C@H](O)[C@@H](O)[C@H](C)O7)O)CC[C@]6(C)[C@H]5CC=3)(C)CC4)O2)O)[C@H](O)[C@H]1O RYHDIBJJJRNDSX-MCGLQMIESA-N 0.000 title claims abstract description 53
- RYHDIBJJJRNDSX-UHFFFAOYSA-N kalopanax-saponin B Natural products OC1C(O)C(O)C(C)OC1OC1C(CO)OC(OCC2C(C(O)C(O)C(OC(=O)C34C(CC(C)(C)CC3)C=3C(C5(C)CCC6C(C)(CO)C(OC7C(C(O)C(O)CO7)OC7C(C(O)C(O)C(C)O7)O)CCC6(C)C5CC=3)(C)CC4)O2)O)C(O)C1O RYHDIBJJJRNDSX-UHFFFAOYSA-N 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 44
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 title abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 104
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 52
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 39
- 238000000605 extraction Methods 0.000 claims abstract description 38
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000243 solution Substances 0.000 claims abstract description 31
- 239000003960 organic solvent Substances 0.000 claims abstract description 25
- 238000001556 precipitation Methods 0.000 claims abstract description 23
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 20
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 16
- 239000003463 adsorbent Substances 0.000 claims abstract description 13
- 239000011259 mixed solution Substances 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000001953 recrystallisation Methods 0.000 claims abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 6
- 239000012535 impurity Substances 0.000 claims abstract description 5
- 238000002425 crystallisation Methods 0.000 claims abstract description 4
- 230000008025 crystallization Effects 0.000 claims abstract description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 20
- 230000007062 hydrolysis Effects 0.000 claims description 19
- 238000006460 hydrolysis reaction Methods 0.000 claims description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000005903 acid hydrolysis reaction Methods 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- UXTMROKLAAOEQO-UHFFFAOYSA-N chloroform;ethanol Chemical compound CCO.ClC(Cl)Cl UXTMROKLAAOEQO-UHFFFAOYSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- NBEMQPLNBYYUAZ-UHFFFAOYSA-N ethyl acetate;propan-2-one Chemical compound CC(C)=O.CCOC(C)=O NBEMQPLNBYYUAZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 7
- 239000012046 mixed solvent Substances 0.000 claims description 7
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 5
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 claims description 5
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical class [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- 235000011054 acetic acid Nutrition 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 239000001117 sulphuric acid Substances 0.000 claims description 3
- 235000011149 sulphuric acid Nutrition 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 abstract description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 description 8
- 239000000178 monomer Substances 0.000 description 8
- 229930182470 glycoside Natural products 0.000 description 7
- 150000002338 glycosides Chemical class 0.000 description 7
- 229930182490 saponin Natural products 0.000 description 7
- 150000007949 saponins Chemical class 0.000 description 7
- 235000017709 saponins Nutrition 0.000 description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- KEOITPILCOILGM-FCWYPSSHSA-N Sapindoside A Natural products O=C(O)[C@]12[C@H](C=3[C@](C)([C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O7)[C@H](O)[C@H](O)CO6)CC5)CC4)CC=3)CC1)CC(C)(C)CC2 KEOITPILCOILGM-FCWYPSSHSA-N 0.000 description 4
- KBYYTUYPCGPQNK-UHFFFAOYSA-N alpha-hederin Natural products CC1OC(OC2C(O)C(CO)OC2OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)O)C3(C)CO)C(O)C(O)C1O KBYYTUYPCGPQNK-UHFFFAOYSA-N 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- KEOITPILCOILGM-LLJOFIFVSA-N kalopanaxsaponin A Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@@]([C@H]3[C@]([C@@H]4[C@@]([C@@]5(CC[C@]6(CCC(C)(C)C[C@H]6C5=CC4)C(O)=O)C)(C)CC3)(C)CC2)(C)CO)OC[C@H](O)[C@@H]1O KEOITPILCOILGM-LLJOFIFVSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000000344 soap Substances 0.000 description 4
- 241000345998 Calamus manan Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000012950 rattan cane Nutrition 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229960001866 silicon dioxide Drugs 0.000 description 3
- 241000208341 Hedera Species 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 241001671656 Hedera rhombea Species 0.000 description 1
- 229930187944 Hederacoside Natural products 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001518085 Nigella glandulifera Species 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 241000131808 Scolopendra Species 0.000 description 1
- 241001074085 Scophthalmus aquosus Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310618958.2A CN103588832B (zh) | 2013-11-26 | 2013-11-26 | 从常春藤叶中分离常春藤苷c及苷元的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310618958.2A CN103588832B (zh) | 2013-11-26 | 2013-11-26 | 从常春藤叶中分离常春藤苷c及苷元的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103588832A CN103588832A (zh) | 2014-02-19 |
CN103588832B true CN103588832B (zh) | 2017-01-04 |
Family
ID=50079183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310618958.2A Active CN103588832B (zh) | 2013-11-26 | 2013-11-26 | 从常春藤叶中分离常春藤苷c及苷元的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103588832B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103800930A (zh) * | 2014-02-25 | 2014-05-21 | 云南天宏香精香料有限公司 | 一种空气清新剂及制备方法 |
CN105237608B (zh) * | 2015-09-30 | 2017-03-22 | 桂林益元素生物科技有限公司 | 一种从常春藤中提取常春藤苷的方法 |
CN114805466B (zh) * | 2022-04-15 | 2023-06-20 | 湖南朗林生物资源股份有限公司 | 一种常春藤提取物的制备方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1384110A (zh) * | 2002-05-20 | 2002-12-11 | 吉林天药科技股份有限公司 | 常青藤皂苷元的制备方法 |
CN1767842A (zh) * | 2003-04-02 | 2006-05-03 | 恩格哈德药物有限及两合公司 | 制备常春藤叶提取物的方法 |
CN1852724A (zh) * | 2003-09-19 | 2006-10-25 | 恩格哈德药物有限及两合公司 | 制备贮存稳定的常春藤叶提取物的方法及根据该方法制备的提取物 |
CN101235068A (zh) * | 2007-01-29 | 2008-08-06 | 中南大学 | 一种从常春藤中制备常春藤苷c的方法 |
CN102188465A (zh) * | 2011-04-18 | 2011-09-21 | 中国中医科学院中药研究所 | 一种常春藤属植物提取物的制备方法及其用途 |
CN102633857A (zh) * | 2012-04-24 | 2012-08-15 | 吉林大学 | 一种常春藤皂苷元的提取方法 |
CN101792479B (zh) * | 2010-04-02 | 2013-11-13 | 江西中医学院 | 青钱柳降血糖活性皂苷的提取工艺 |
-
2013
- 2013-11-26 CN CN201310618958.2A patent/CN103588832B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1384110A (zh) * | 2002-05-20 | 2002-12-11 | 吉林天药科技股份有限公司 | 常青藤皂苷元的制备方法 |
CN1767842A (zh) * | 2003-04-02 | 2006-05-03 | 恩格哈德药物有限及两合公司 | 制备常春藤叶提取物的方法 |
CN1852724A (zh) * | 2003-09-19 | 2006-10-25 | 恩格哈德药物有限及两合公司 | 制备贮存稳定的常春藤叶提取物的方法及根据该方法制备的提取物 |
CN101235068A (zh) * | 2007-01-29 | 2008-08-06 | 中南大学 | 一种从常春藤中制备常春藤苷c的方法 |
CN101792479B (zh) * | 2010-04-02 | 2013-11-13 | 江西中医学院 | 青钱柳降血糖活性皂苷的提取工艺 |
CN102188465A (zh) * | 2011-04-18 | 2011-09-21 | 中国中医科学院中药研究所 | 一种常春藤属植物提取物的制备方法及其用途 |
CN102633857A (zh) * | 2012-04-24 | 2012-08-15 | 吉林大学 | 一种常春藤皂苷元的提取方法 |
Non-Patent Citations (2)
Title |
---|
中华常春藤中皂苷类成分和挥发油奋力分析研究;童星;《中南大学硕士学位论文》;20070630;第1-64页 * |
川续断的化学成分和质量标准研究;朱净民;《北京大学中医药大学硕士研究生学位论文》;20110930;第1-75页 * |
Also Published As
Publication number | Publication date |
---|---|
CN103588832A (zh) | 2014-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110845328A (zh) | 一种以迷迭香油膏副产品制备高纯度鼠尾草酸的方法 | |
CN103204765A (zh) | 一种从废次烟叶中提取茄尼醇和绿原酸的方法 | |
CN103588832B (zh) | 从常春藤叶中分离常春藤苷c及苷元的方法 | |
CN102351939A (zh) | 一种从女贞中联合制备高纯度熊果酸和齐墩果酸的方法 | |
CN101445451B (zh) | 一种高纯度丹参素钠的制备方法 | |
CN101348474A (zh) | 一种从丹参茎叶中制备丹酚酸b和丹参素的方法 | |
CN101407535A (zh) | 一种高纯度罗汉果甜甙v的制备方法 | |
CN102731592A (zh) | 一种从橄榄叶提取橄榄苦甙和穗花杉双黄酮的方法 | |
CN106496034A (zh) | 一种同时从烟叶中提取分离绿原酸和芸香苷的方法 | |
CN102942611A (zh) | 制备高纯度赛门苷ⅰ的方法 | |
CN102351782B (zh) | 一种从桑叶中提取1-脱氧野尻霉素和白藜芦醇的方法 | |
CN101434534A (zh) | 丹参素钠纯品的制备方法 | |
CN103086967A (zh) | 瘤果黑种草籽中具有骨架类型1的生物碱及其制备方法 | |
CN102690359B (zh) | 一种从罗汉果块根中提取淀粉和葫芦素的方法 | |
CN102329345A (zh) | 垂盆草中垂盆草苷的提取纯化方法 | |
CN101891729B (zh) | 一种从青天葵中提取高纯度鼠李秦素的方法 | |
CN102241656A (zh) | 一种苜蓿素的制备方法 | |
CN104250279A (zh) | 一种24-羟基甘草酸制备方法 | |
CN101875685A (zh) | 皂甙含量≥30%的灵香草皂甙提取物及其提取工艺 | |
CN102351828A (zh) | 一种提取金雀异黄素的新工艺 | |
CN101429225B (zh) | 一种积雪草苷酸水解制备积雪草酸的方法 | |
CN109970838A (zh) | 一种长梗冬青苷的制备方法 | |
CN103193750B (zh) | 一种利用大孔树脂xad7hp联合分离制备莽草酸和八角黄酮的方法 | |
CN1660832B (zh) | 从黄芪中提取和分离黄芪总黄酮和皂甙的方法 | |
CN109265428A (zh) | 一种流苏菲的提取制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 710075 Xi'an high tech Zone, Shaanxi hi tech Road, No. 25 Maple Leaf Garden District, block C, No. 157 Applicant after: SHAANXI JIAHE PHYTOCHEM CO., LTD. Address before: 710075 Xi'an high tech Zone, Shaanxi hi tech Road, No. 25 Maple Leaf Garden District, block C, No. 157 Applicant before: Shanxi Jiahe Plant Chemical Co., Ltd. |
|
COR | Change of bibliographic data | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for separating hederacoside C and aglycone from hedera helix leaf Effective date of registration: 20180206 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190326 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for separating hederacoside C and aglycone from hedera helix leaf Effective date of registration: 20190411 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2019610000066 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200616 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: 2019610000066 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Isolation of ivy C and aglycone from leaves of ivy Effective date of registration: 20200910 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210602 Granted publication date: 20170104 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20140219 Assignee: Sanyuan Runhe Biological Technology Co.,Ltd. Assignor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Contract record no.: X2021980014416 Denomination of invention: Method for separating Ivy glycoside C and aglycone from ivy leaves Granted publication date: 20170104 License type: Common License Record date: 20211208 Application publication date: 20140219 Assignee: SHAANXI JIAHE PHARMACEUTICAL CO.,LTD. Assignor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Contract record no.: X2021980014566 Denomination of invention: Method for separating Ivy glycoside C and aglycone from ivy leaves Granted publication date: 20170104 License type: Common License Record date: 20211209 |