CN103566333A

CN103566333A - Pharmaceutical composition for relieving swelling and pain and preparation method thereof

Info

Publication number: CN103566333A
Application number: CN201210283458.3A
Authority: CN
Inventors: 康凤林
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-02
Filing date: 2012-08-02
Publication date: 2014-02-12

Abstract

The invention discloses a pharmaceutical composition for relieving swelling and pain and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials according to a formula ratio: szechuan lovage rhizome, liquorice, red flower, platycodon grandiflorum, rheum officinale, Chinese angelica, red paeony root, mother chrysanthemum, dandelion, radix bupleuri, ginger, rosin, Chinese violet, radix angelicae and gelatin. The raw materials are prepared into paste, membranes and powder for polonium application by extracting active ingredients and adding the gelatin. The medicines are compatible and have the effects of clearing and activating the channels and collaterals, relieving swelling and pain, invigorating the circulation of blood and dissipating blood stasis, expelling wind and removing cold and expelling pus and toxin. The pharmaceutical composition has the advantages of capacity of rapidly relieving swelling and pain, lasting curative effect, good pain relieving effect, zero toxic or side effect and convenience and safety in use, is a preferred external drug for bruises sprains, cervical spondylosis, malignant boil, boil sore and the like, and is a novel swelling and pain-relieving external traditional Chinese medicine preparation with high popularization value.

Description

A kind of drug regimen for reducing swelling and alleviating pain and preparation method thereof

Technical field

The invention belongs to Chinese medicine preparation technical field, being specifically related to a kind of drug regimen for reducing swelling and alleviating pain and preparation method thereof is drug regimen and the preparation method for diseases such as osteopatia sprain, cervical spondylosis, treatment, furuncle swell specifically.

Technical background

Traumatic injury comprises weapons, tumbling down, hits, sprain and contusion, stab, scratch, athletic injury etc., there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more, at this, mainly take soft tissue injury as main.Think China's hall and think that traumatic injury stopped up stagnantly by congestion, blood is held one's breath due to resistance, and take pain, swelling is main manifestations, therefore take blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain in treatment, is main principle.Symptom is that local swelling, pain, ecchymosis, limb activity are limited etc.Sprain the congestion swelling of rear injury, blockage of main and collateral channels, QI and blood retardance.

Cervical spondylosis refers to that the plump hypertrophy of degeneration of cervical intervertebral disc, cervical vertebra and neck injury etc. cause hyperosteogeny of cervical vertebra, or prolapse of intervertebral disc, ligament thicken, and stimulates or compressing cervical spinal, cervical region are neural, blood vessel and produce the clinical syndrome of series of symptoms.Main manifestations is the two lower limb spasm of neck and shoulder pain, dizziness headache, upper limb numbness, amyotrophy, severe patient, difficulty in walking, quadriplegia even, and, there is paralysis in defecation obstacle.

Furuncle is that skin hair is assisted or the acute suppurative inflammation of sebaceous gland, is common disease.General be multiplely born in summer, any position all can occur.And take women's head-ornaments, the back of the body and oxter as common.It is characterized in that color is red, scorching hot, pain, shallow, the swollen gesture limitation of projection root, pus go out to heal.Its etiology and pathogenesis is diseases caused by exogenous pathogenic factor pyretic toxicity, or retention of damp-heat in the interior, and pyretic toxicity must not leak, and hinders due to the skin.

Above these illness be due to the unclean blood capillary of muscle blood and microcirculation smooth due to, the general normal employing of most people is such as the methods such as physiotherapy, operation, endo-medicine are treated, treatment is complicated like this, curative effect is rapid, side effect is large and expensive.Preferably adopt targetedly external medication, external application Traditional Chinese Medicine surgery plaster, remarkable by plaster external application effect.The Chinese medicine preparation of external application just arises at the historic moment like this, but some liniments that occur on market, specific aim is not strong, and the efficacy of a drug can not well be concentrated, and obviously just can not effectively be penetrated into deep tissues, and the effect of reducing swelling and alleviating pain has just been lost.The present invention by skin conductance to meridians, muscles and bones, excite the regulatory function of human body, can eliminate and swell and ache rapidly, the effect that dredge the meridian passage, reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis, expelling wind and cold, evacuation of pus are drawn out pus by applying a plaster to the affected part be greatly improved, and promotion functions recovers and reaches fast healing object.

Therefore, patient colony is huge, and the medicine for the treatment of reducing swelling and alleviating pain has the very large market space, so medicine of the present invention will bring huge Social benefit and economic benefit.

Summary of the invention

Be to provide preparation a kind of for curing drug regimen of the illness such as osteopatia sprain, cervical spondylosis, furuncle, furuncle be swollen and preparation method thereof, to overcome the deficiency of existing medicine order of the present invention.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is the preparation of being made by the raw material of following weight proportioning:

Rhizoma Chuanxiong 15-40 part Radix Glycyrrhizae 15-40 part Flos Carthami 30-80 part Radix Platycodonis 10-30 part Radix Et Rhizoma Rhei 8-30 part Radix Angelicae Sinensis 20-45 part Radix Paeoniae Rubra 8-25 part Flos Chrysanthemi Indici 20-45 part Herba Taraxaci 20-50 part Radix Bupleuri 20-45 part Rhizoma Zingiberis Recens 15-35 part Colophonium 20-40 part Herba Violae 15-35 part Radix Angelicae Dahuricae 15-50 part gelatin 20-50 part

2, best each raw material weight proportioning of formula of the present invention is:

33 parts, 25 parts of gelatin of 30 parts of Radixs Angelicae Dahuricae of 15 parts of Herba Violaes of 30 parts of Colophonium of 30 portions of Rhizoma Zingiberis Recenss of 33 parts of Radix Bupleuri of 11 parts of Herba Taraxacis of 11 parts of Flos Chrysanthemi Indicis of 30 parts of Radix Paeoniae Rubra of 15 parts of Radix Angelicae Sinensis of 15 parts of Radix Et Rhizoma Rhei of 55 parts of Radix Platycodoniss of 22 parts of Flos Carthamis of 25 portions of Radix Glycyrrhizaes of Rhizoma Chuanxiong

3, preparation technology

(1) get Rhizoma Zingiberis Recens, the alcohol dipping with 60～70% 24～48 hours, filters, and collects filtrate, standby;

(2) get Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Colophonium powder and be broken into coarse powder, according to the percolation under fluid extract and extractum item, with 65～75% ethanol, make solvent, flood and after 48-96 hour, carry out percolation (18～25 ℃), with the speed of 1～3ml per minute percolation slowly, collect approximately 800～1500ml of percolate, standing 24 hours, filter filtrate for later use;

(3) extracting liquorice, Radix Platycodonis, Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Herba Taraxaci, Radix Bupleuri, Herba Violae, each medicine of the Radix Angelicae Dahuricae decoct with water 2～4 times, each 1～3 hour, filter merging filtrate; In filtrate, add ethanol, make concentration of alcohol in filtrate reach 50～65% (V/V), cold preservation 12 hours, filters, and filtrate subtracts counterfeit recovery ethanol to concentrated solution;

(4) by above-mentioned three kinds of filtrates, after mixing, at the temperature of 60～80 ℃, be concentrated into relative density and be 1.33～1.35 thick paste, add gelatin, make unguentum, membrane, powder for external application.

The present invention is containing hypertoxicity composition, and without incompatibility, in side, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae have the effect of reducing swelling and alleviating pain, and Radix Angelicae Sinensis, Flos Carthami have the effect of blood circulation promoting and blood stasis dispelling, Rhizoma Zingiberis Recens can warming middle-JIAO by cold, Colophonium dispeiling pathogenic wind and removing dampness, evacuation of pus are drawn out pus by applying a plaster to the affected part, granulation promoting pain relieving, the furuncle of living, furuncle are swollen.Adopt said medicine combination and make each method, all composition compatibilities are coordinated mutually, have the effect that dredge the meridian passage, reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis, expelling wind and cold, evacuation of pus are drawn out pus by applying a plaster to the affected part.

Specific embodiment:

Adopt following prescription:

Its preparation technology is:

Get Rhizoma Zingiberis Recens, the alcohol dipping with 65% 24 hours, filters, and collects filtrate, standby;

Get Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Colophonium powder and be broken into coarse powder, according to the percolation under fluid extract and extractum item, with 70% ethanol, make solvent, flood and after 72 hours, carry out percolation (22 ℃), with the speed of 2ml per minute percolation slowly, collect the about 1000ml of percolate, standing 24 hours, filter filtrate for later use;

Extracting liquorice, Radix Platycodonis, Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Herba Taraxaci, Radix Bupleuri, Herba Violae, each medicine of the Radix Angelicae Dahuricae decoct with water 3 times, each 2 hours, filter merging filtrate; In filtrate, add ethanol, make concentration of alcohol in filtrate reach approximately 60% (V/V), cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to concentrated solution;

By above-mentioned three kinds of filtrates, after mixing, at the temperature of 75 ℃, be concentrated into relative density and be 1.33～1.35 thick paste, add gelatin, make the unguentum for external application.

Claims

1. for a drug regimen for reducing swelling and alleviating pain, it is characterized in that it is to be made by the raw material of following weight: Rhizoma Chuanxiong 15-40 part Radix Glycyrrhizae 15-40 part Flos Carthami 30-80 part Radix Platycodonis 10-30 part Radix Et Rhizoma Rhei 8-30 part Radix Angelicae Sinensis 20-45 part Radix Paeoniae Rubra 8-25 part Flos Chrysanthemi Indici 20-45 part Herba Taraxaci 20-50 part Radix Bupleuri 20-45 part Rhizoma Zingiberis Recens 15-35 part Colophonium 20-40 part Herba Violae 15-35 part Radix Angelicae Dahuricae 15-50 part gelatin 20-50 part

2. a kind of drug regimen for reducing swelling and alleviating pain as claimed in claim 1, is characterized in that it is to be made by the raw material of following weight:

3. a kind of drug regimen for reducing swelling and alleviating pain as claimed in claim 2, is characterized in that the preparation technology of said preparation is:

(2) get Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Colophonium powder and be broken into coarse powder, according to the percolation under fluid extract and extractum item, with 65～75% ethanol, make solvent, flood and after 48-96 hour, carry out percolation (18～25 ℃), with the speed of 1～3ml per minute percolation slowly, collect approximately standing 24 hours of 800～1500ml. of percolate, filter filtrate for later use:

(3) extracting liquorice, Radix Platycodonis, Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Herba Taraxaci, Radix Bupleuri, Herba Violae, each medicine of the Radix Angelicae Dahuricae decoct with water 2～4 times, each 1～3 hour, filter merging filtrate; In filtrate, add ethanol, make concentration of alcohol in filtrate reach 50～6526 (V/V), cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to concentrated solution;

(4) by above-mentioned three kinds of filtrates, after mixing, at the temperature of 60～80 ℃, be concentrated into relative density and be 1.33～1.35 thick paste and add gelatin, make unguentum, membrane, powder for external application.