CN103536612B - 硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 - Google Patents
硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 Download PDFInfo
- Publication number
- CN103536612B CN103536612B CN201310473186.8A CN201310473186A CN103536612B CN 103536612 B CN103536612 B CN 103536612B CN 201310473186 A CN201310473186 A CN 201310473186A CN 103536612 B CN103536612 B CN 103536612B
- Authority
- CN
- China
- Prior art keywords
- nifuratel
- expansible plug
- expandable
- nystatin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960000988 nystatin Drugs 0.000 title claims abstract description 78
- 238000001514 detection method Methods 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000000758 substrate Substances 0.000 claims abstract description 68
- 235000010603 pastilles Nutrition 0.000 claims abstract description 62
- SRQKTCXJCCHINN-NYYWCZLTSA-N nifuratel Chemical compound O=C1OC(CSC)CN1\N=C\C1=CC=C([N+]([O-])=O)O1 SRQKTCXJCCHINN-NYYWCZLTSA-N 0.000 claims abstract description 58
- 229960002136 nifuratel Drugs 0.000 claims abstract description 58
- 239000000829 suppository Substances 0.000 claims abstract description 45
- 238000010521 absorption reaction Methods 0.000 claims abstract description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 11
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 claims abstract description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000008119 colloidal silica Substances 0.000 claims abstract description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 10
- 229960003943 hypromellose Drugs 0.000 claims abstract description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- 229940093625 propylene glycol monostearate Drugs 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 50
- 229920000742 Cotton Polymers 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 238000003556 assay Methods 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 21
- 238000002844 melting Methods 0.000 claims description 19
- 230000008018 melting Effects 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 16
- 230000008859 change Effects 0.000 claims description 14
- 125000005456 glyceride group Chemical group 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 229920006395 saturated elastomer Polymers 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 8
- 238000005096 rolling process Methods 0.000 claims description 8
- -1 behenic acid ester Chemical class 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 6
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 claims description 6
- 235000021357 Behenic acid Nutrition 0.000 claims description 5
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 5
- 229940116226 behenic acid Drugs 0.000 claims description 5
- 239000004519 grease Substances 0.000 claims description 5
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
- 244000060011 Cocos nucifera Species 0.000 claims description 3
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 229960001947 tripalmitin Drugs 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 239000005639 Lauric acid Substances 0.000 claims description 2
- 239000000346 nonvolatile oil Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 13
- 210000001215 vagina Anatomy 0.000 abstract description 11
- 206010042566 Superinfection Diseases 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 26
- 239000000126 substance Substances 0.000 description 9
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 6
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 235000019197 fats Nutrition 0.000 description 4
- 206010046914 Vaginal infection Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- 241000549173 Celastrus scandens Species 0.000 description 2
- 241001478240 Coccus Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000405070 Percophidae Species 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 208000008350 Pruritus Vulvae Diseases 0.000 description 2
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000007766 cera flava Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 229940044977 vaginal tablet Drugs 0.000 description 2
- 239000000003 vaginal tablet Substances 0.000 description 2
- 244000066764 Ailanthus triphysa Species 0.000 description 1
- 208000007415 Anhedonia Diseases 0.000 description 1
- 235000003276 Apios tuberosa Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000010744 Arachis villosulicarpa Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 229920002642 Polysorbate 65 Polymers 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 description 1
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940099511 polysorbate 65 Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
实施例 | 膨胀前平均直径(mm) | 膨胀后平均直径(mm) | 膨胀值(倍) | 结果 |
实施例1 | 12.33 | 22.48 | 1.82 | 合格 |
实施例2 | 11.91 | 21.36 | 1.79 | 合格 |
实施例3 | 12.05 | 22.54 | 1.87 | 合格 |
实施例4 | 12.17 | 22.66 | 1.86 | 合格 |
实施例5 | 12.09 | 21.47 | 1.77 | 合格 |
实施例6 | 11.98 | 19.12 | 1.60 | 合格 |
实施例7 | 12.24 | 20.67 | 1.69 | 合格 |
实施例8 | 12.13 | 21.93 | 1.81 | 合格 |
组别 | 病例数 | 症愈 | 显效 | 有效 | 无效 | 有效率(%) |
治疗组 | 50 | 40 | 3 | 6 | 1 | 98.0 |
对照组 | 34 | 20 | 5 | 2 | 7 | 79.4 |
组别 | 病例数 | 症愈 | 显效 | 有效 | 无效 | 有效率(%) |
治疗组 | 31 | 25 | 3 | 2 | 1 | 96.8 |
对照组 | 19 | 11 | 1 | 3 | 4 | 78.9 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310473186.8A CN103536612B (zh) | 2013-10-11 | 2013-10-11 | 硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310473186.8A CN103536612B (zh) | 2013-10-11 | 2013-10-11 | 硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103536612A CN103536612A (zh) | 2014-01-29 |
CN103536612B true CN103536612B (zh) | 2016-03-30 |
Family
ID=49960726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310473186.8A Active CN103536612B (zh) | 2013-10-11 | 2013-10-11 | 硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103536612B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104983671B (zh) * | 2015-06-30 | 2018-11-02 | 哈尔滨欧替药业有限公司 | 重组人粒细胞巨噬细胞刺激因子***膨胀栓及其制备方法和检测方法 |
CN111557897B (zh) * | 2020-07-07 | 2023-06-23 | 温州海鹤药业有限公司 | 一种含有硝呋太尔的药物组合物及其制备方法 |
CN113828243B (zh) * | 2021-09-14 | 2022-06-28 | 南京南大药业有限责任公司 | 一种硝呋太尔制霉菌素栓制造方法及设备 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103181889A (zh) * | 2012-11-29 | 2013-07-03 | 哈尔滨欧替药业有限公司 | 膨胀***栓剂 |
CN103301098A (zh) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | 复方氯己定盐***膨胀栓及其制备方法和检测方法 |
-
2013
- 2013-10-11 CN CN201310473186.8A patent/CN103536612B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103181889A (zh) * | 2012-11-29 | 2013-07-03 | 哈尔滨欧替药业有限公司 | 膨胀***栓剂 |
CN103301098A (zh) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | 复方氯己定盐***膨胀栓及其制备方法和检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CN103536612A (zh) | 2014-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103301098B (zh) | 复方氯己定盐***膨胀栓及其制备方法和检测方法 | |
CN103520090B (zh) | 替硝唑***膨胀栓及其制备方法和检测方法 | |
CN103720640B (zh) | 聚维酮碘***膨胀栓及其制备方法和检测方法 | |
CN103536612B (zh) | 硝呋太尔-制霉素***膨胀栓及其制备方法和检测方法 | |
CN103784390B (zh) | 塞克硝唑***膨胀栓及其制备方法和检测方法 | |
CN103751098B (zh) | 重组人干扰素α2а***膨胀栓及其制备方法和检测方法 | |
CN103751094B (zh) | 奥硝唑***膨胀栓及其制备方法和检测方法 | |
CN103520604B (zh) | 百草妇炎清***膨胀栓及其制备方法和检测方法 | |
CN103520380B (zh) | 裸花紫珠***膨胀栓及其制备方法和检测方法 | |
CN103536592B (zh) | 甲硝唑呋喃唑酮***膨胀栓及其制备方法和检测方法 | |
CN103520086B (zh) | 硝酸咪康唑***膨胀栓及其制备方法和检测方法 | |
CN103893107B (zh) | 硝酸舍他康唑***膨胀栓及其制备方法和检测方法 | |
CN103520089B (zh) | 甲硝唑***膨胀栓及其制备方法和检测方法 | |
CN103494767B (zh) | 雌三醇***膨胀栓及其制备方法和检测方法 | |
CN103735492B (zh) | ******膨胀栓及其制备方法和检测方法 | |
CN103768005B (zh) | 酮康唑***膨胀栓及其制备方法和检测方法 | |
CN103520338B (zh) | 治糜康***膨胀栓及其制备方法和检测方法 | |
CN103735491B (zh) | 克林霉素磷酸酯***膨胀栓及其制备方法和检测方法 | |
CN103520088B (zh) | 制霉素***膨胀栓及其制备方法和检测方法 | |
CN103494768B (zh) | 环吡酮胺***膨胀栓及其制备方法和检测方法 | |
CN103494896B (zh) | 蛇黄***膨胀栓及其制备方法和检测方法 | |
CN103720638B (zh) | 硝酸芬替康唑***膨胀栓及其制备方法和检测方法 | |
CN103520603B (zh) | 妇炎灵***膨胀栓及其制备方法和检测方法 | |
CN103768095B (zh) | 复方氯霉素***膨胀栓及其制备方法和检测方法 | |
CN103520635B (zh) | 复方莪术油***膨胀栓及其制备方法和检测方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20211119 Address after: 150040 office building 7, Bohai Third Road, haping road concentration area, Harbin Economic Development Zone, Harbin, Heilongjiang Province Patentee after: Harbin Tianmei Pharmaceutical Co.,Ltd. Address before: 150069, No. three, No. 7, Bohai, Harbin, Heilongjiang, China Patentee before: HARBIN OT PHARMACEUTICALS Co.,Ltd. Patentee before: Qiu Mingshi |
|
TR01 | Transfer of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Nitrofuretyl nystatin vaginal dilation suppository and its preparation and detection method Effective date of registration: 20230704 Granted publication date: 20160330 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000060 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20160330 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000060 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Nifurol Nystatin Vaginal Dilation Suppository and Its Preparation and Detection Methods Granted publication date: 20160330 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2024230000040 |