CN103520538A - Medicinal composition for treating renal damage caused by diabetes - Google Patents
Medicinal composition for treating renal damage caused by diabetes Download PDFInfo
- Publication number
- CN103520538A CN103520538A CN201310480081.5A CN201310480081A CN103520538A CN 103520538 A CN103520538 A CN 103520538A CN 201310480081 A CN201310480081 A CN 201310480081A CN 103520538 A CN103520538 A CN 103520538A
- Authority
- CN
- China
- Prior art keywords
- parts
- diabetes
- medicinal composition
- cortex
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicinal composition for treating renal damage caused by diabetes, and aims to solve the problems of treatment of diabetic nephropathy. The medicinal composition is characterized in that the medicinal composition is prepared from the following raw medicaments in parts by weight: fructus cannabis, chingma abutilon seeds, magnolia amoena, poncirus barks, Chinese taxillus twigs, allium victorialis, gastrodia fruits, radix ranunculi ternati, Chinese starjasmine stems, erythrina indica lam, cassia twigs and rice-grain sprouts. Clinical experiments show that the medicinal composition for treating renal damage caused by diabetes has the characteristics of good curative effects and higher safety, and has high clinical application and popularization value.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition that diabetes cause kidney damage for the treatment of.
Background technology
Foreign literature report, there is microalbuminuria in the course of disease type i diabetes patient of 10 ~ 15 years 40%～50%, and the result of the research simultaneously also shows: type ii diabetes also has 20%～30% diabetic nephropathy occurs at viewing duration.So-called diabetic nephropathy (diabetic nephropathy, DN), be one of most important complication of diabetic, also in rising trend at the sickness rate of China in recent years, the second reason that has become at present nephropathy in latter stage at end, is only second to various glomerulonephritiies.Because it exists complicated metabolism disorder, once develop into nephropathy in latter stage at end, often more thorny than the treatment of other kidney diseases, therefore control is in time for delaying the significant of diabetic nephropathy.
The diabetic nephropathy cause of disease and pathogenesis are still unclear at present.Inventor's clinical research is for many years found, the effect of the Developmental and Metabolic Disorder that hyperglycemia causes in diabetic nephropathy pathology process is particularly outstanding, wherein Developmental and Metabolic Disorder causes the mechanism of kidney damage mainly to comprise: the 1. local carbohydrate metabolism disturbance of nephridial tissue, can form advanced glycosylation endproduct end metabolite (AGES) by nonenzymatic glycosylation; 2. the activation of polyhydric alcohol path; 3. the activation of DG-protein kinase c approach; 4. osamine path Developmental and Metabolic Disorder.Above-mentioned Developmental and Metabolic Disorder is removed and is participated in early stage high filtration, and what is more important promotion glomerular basement membrane (GBM) thickens with extracellular matrix to be accumulated.
Because the cause of disease is unclear, so diabetes kidney damage clinical treatment is mainly symptomatic treatment: 1. control blood glucose; 2. control blood pressure; 3. dietetic therapy.The diabetic complication of diabetic nephropathy patients undergoing itself is common, and uremia symptom occurs early, and general endogenous creatinine clearance rate is down to 10～15ml/min will maintenance dialysis, patient economy burden weight.The traditional Chinese medical science is recorded without primary disease, and treatment is how identical with diabetes, discusses and controls from: the scorching deficiency of YIN, with the passing of time consumes gas and cause deficiency of both QI and YIN, and PD is deficiency of YIN affecting YANG and see deficiency of both YIN and YANG, even the sun turbid malicious stasis blocking that declines.Owing to not fully taking into account the effect in diabetic nephropathy pathology process of Developmental and Metabolic Disorder that hyperglycemia causes, so current Chinese traditional treatment there is no help for delaying kidney damage.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little treatment diabetes of side effect cause the pharmaceutical composition of kidney damage.
The technical scheme that the present invention solves its technical problem is: a kind ofly treat the pharmaceutical composition that diabetes cause kidney damage, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Fructus Cannabiss, 6 ~ 12 parts of certain herbaceous plants with big flowers colza, 3 ~ 10 parts of Flos Magnoliae Amoenae, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 3 ~ 10 parts of Herba Taxillis, 6 ~ 12 parts of Bulbus Allii Victorialis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Caulis Trachelospermis, 1 ~ 5 part of Cortex erythrinae, 3 ~ 10 parts of Ramulus Cinnamomi, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Fructus Cannabiss, 10 parts of certain herbaceous plants with big flowers colza, 6 parts of Flos Magnoliae Amoenae, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Herba Taxillis, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of Radix Ranunculi Ternatis, 10 parts of Caulis Trachelospermis, 2 parts of Cortex erythrinaes, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
Wherein said: Fructus Cannabis is the dry mature fruit of moraceae plants Fructus Cannabis Cannabis sativa L..Nature and flavor are sweet, flat.Return spleen, stomach, large intestine channel.Merit can loosening bowel to relieve constipation.
Certain herbaceous plants with big flowers colza is the mature seed of Malvaceae herbaceous plant Semen Abutili AbutilontheophrastiiMedic.Nature and flavor are sweet, cold.Return large intestine, small intestine meridian.Merit is can clearing away heat and promoting diuresis treating stranguria, lactogenesis, intestine moistening.
Flos Magnoliae Amoenae, for Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, cold.Merit can diuresis, detumescence, nourishing the lung to arrest cough.
Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Herba Taxilli, for Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Merit can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.Merit can dissipating blood stasis; Hemostasis; Removing toxic substances.
Also bobbin, is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.
Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.Return kidney, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.
Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor are bitter, flat.Return liver, kidney channel.Merit can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Fructus Setariae Germinatus (parched to brown), dry through germinateing for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv., according to frying method, fry to burnt brown.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Clinical the past is studied and shows, DN is mainly present in type i diabetes, and natural history starts for 10 ~ 15 years, and type i diabetes patient starts to occur continuous micro albuminuria, and glomerule nodule-like lesions and small artery vitreous degeneration appear in Pathological.The basis of this pathological change is that hyperglycemia causes Developmental and Metabolic Disorder, promotes glomerular basement membrane (GBM) to thicken with extracellular matrix and accumulates.At present, Chinese traditional treatment is not for the medicine typing of DN, and treatment is how identical with diabetes, discusses and controls from: the scorching deficiency of YIN, with the passing of time consumes gas and cause deficiency of both QI and YIN, and PD is deficiency of YIN affecting YANG and see deficiency of both YIN and YANG, even the sun turbid malicious stasis blocking that declines.Owing to not fully taking into account the effect in diabetic nephropathy pathology process of Developmental and Metabolic Disorder that hyperglycemia causes, so there is no help for delaying kidney damage.
Inventor thinks: existing traditional Chinese medical therapeutic program is many starts with from the deficiency of YIN; but another pathological factor " expectorant is solidifying " of having ignored primary disease; the diabetes that various pathological factors causes is controlled protracted course of disease for a long time; deficiency in both YIN and YANG; QI and blood is not all right; expectorant coagulates venation, water-damp not being transformed of a specified duration, stop in long-pending body and raw his become.So inventor starts with from this angle, carried out the innovation on prescription.
Compared with prior art, the present invention has following characteristics:
1, set forth one's views unique: diabetic nephropathy is controlled from " QI and blood is not all right, and expectorant coagulate venation " opinion, is that tangible heresy blocked kidney network, causes his change of the not all right and life of kidney network, so get rid of evils as key element.But the pathologic basis of DN is again deficiency in both YIN and YANG, and simulataneous insufficiency and excessive, needs strengthening vital QI to eliminate pathogenic factors.
2, take Fructus Cannabis, certain herbaceous plants with big flowers colza is monarch: inventor's clinical experience gained, and Fructus Cannabis, certain herbaceous plants with big flowers colza are good at except the visible phlegm among venation, and without the anxiety of impairment of YIN, are suitable for DN and use; And Basic pharmacology test confirms: to after rats underwent Fructus Cannabis (20g crude drug/kg/d) and certain herbaceous plants with big flowers colza (10g crude drug/kg/d) mixing water decocting liquid gavage 4w after injection nephrolytic sera with the comparison of GBM nephritis blank group, Rat 24 h urine protein level be only blank organize 43.33%.
3, using Flos Magnoliae Amoenae inducing diuresis to remove edema, Caulis Trachelospermi dispelling wind dredging collateral, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, Bulbus Allii Victorialis dissipating blood stasis, Radix Ranunculi Ternati mass dissipating and swelling eliminating as the auxiliary monarch drug of ministerial drug: accumulation of phlegm retardance, breath does not reach, of a specified duration can produce blood stasis, the stasis of blood is water retention for a long time, so select Cortex Ponciri trifoliatae, Flos Magnoliae Amoenae to remove the visible phlegm in the kidney pulse network, Caulis Trachelospermi, Radix Ranunculi Ternati increase the ability of medicine walking venation.Bulbus Allii Victorialis has the advantages that dissipating blood stasis does not consume gas, and Flos Magnoliae Amoenae diuretic impairment of YIN not, this two herbal medicine is particularly suitable for the treatment of DN deficiency in both YIN and YANG and uses.
4, with Herba Taxilli tonifying the lung Liver and kidney, go back the righting of bobbin tonify deficiency subduing the wind syndrome, low dose of its activating YANG and prormoting functioning of QI of Ramulus Cinnamomi contributes to row loose.
5, low dose of Cortex erythrinae is the gas of damp in stern kidney channel meridians, and power is high so measure micro-.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, in one cold and cool medicine, get and protect the meaning of sun in defending, and contained coking composition has astriction, has the meaning of receipts in loose.
7, the thing homogeneous medicine multiple-effect of getting it filled in side, contributes to reduce medicament categories and consumption, does not increase Liver and kidney burden.
8, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Fructus Cannabis 20g, certain herbaceous plants with big flowers colza 10g, Flos Magnoliae Amoenae 6g, Cortex Ponciri trifoliatae 10g, Herba Taxilli 6g, Bulbus Allii Victorialis 10g, go back bobbin 10g, Radix Ranunculi Ternati 10g, Caulis Trachelospermi 10g, Cortex erythrinae 2g, Ramulus Cinnamomi 6g, Fructus Setariae Germinatus (parched to brown) 20g.
The preparation method of embodiment 1 is: by Fructus Cannabis, certain herbaceous plants with big flowers colza, Flos Magnoliae Amoenae, Cortex Ponciri trifoliatae, Herba Taxilli, Bulbus Allii Victorialis, go back bobbin, Radix Ranunculi Ternati, Caulis Trachelospermi, Cortex erythrinae, Ramulus Cinnamomi, Fructus Setariae Germinatus (parched to brown) mixing and water adding and decoct, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: 10 parts of Fructus Cannabiss, 6 parts of certain herbaceous plants with big flowers colza, 3 parts of Flos Magnoliae Amoenae, 6 parts of Cortex Ponciri trifoliatae, 3 parts of Herba Taxillis, 6 parts of Bulbus Allii Victorialis, go back 6 parts, bobbin, 6 parts of Radix Ranunculi Ternatis, 6 parts of Caulis Trachelospermis, 1 part of Cortex erythrinae, 3 parts of Ramulus Cinnamomi, 10 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 3, crude drug weight proportion: 20 parts of Fructus Cannabiss, 10 parts of certain herbaceous plants with big flowers colza, 6 parts of Flos Magnoliae Amoenae, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Herba Taxillis, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of Radix Ranunculi Ternatis, 10 parts of Caulis Trachelospermis, 2 parts of Cortex erythrinaes, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 4, crude drug weight proportion: 30 parts of Fructus Cannabiss, 12 parts of certain herbaceous plants with big flowers colza, 10 parts of Flos Magnoliae Amoenae, 12 parts of Cortex Ponciri trifoliatae, 10 parts of Herba Taxillis, 12 parts of Bulbus Allii Victorialis, go back 12 parts, bobbin, 12 parts of Radix Ranunculi Ternatis, 12 parts of Caulis Trachelospermis, 5 parts of Cortex erythrinaes, 10 parts of Ramulus Cinnamomi, 25 parts of Fructus Setariae Germinatus (parched to brown).
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) will go back bobbin, certain herbaceous plants with big flowers colza, Herba Taxilli coarse powder and soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are standby;
(2) Cortex erythrinae, Fructus Setariae Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;
(3) gained medicinal residues in Fructus Cannabis, Flos Magnoliae Amoenae, Cortex Ponciri trifoliatae, Bulbus Allii Victorialis, Radix Ranunculi Ternati, Caulis Trachelospermi, Ramulus Cinnamomi and step 1 are mixed with 5 times and measure 80% ethanol extractions 2 times, each 2 hours, merge ethanol extract twice, filter the extractum that when recovery ethanol concentrating under reduced pressure become 60 ℃, relative density is 1.25～1.30;
(4) add gained extractum in step 3 to mix gained fine powder in step 2,60 ℃ of oven dry, are ground into fine powder, add Tween-80 granulation, dry, and granulate, sprays into gained volatile oil in step 1, mixes, and incapsulates, and obtains.
Can set every capsules is 0.5g.
Effective combination of said medicine, coordinates mutually, effectively reach the object for the treatment of diabetic nephropathy, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: case is selected from June, 2006 ~ 2011 and is diagnosed as early diabetic nephropathy 100 examples year June.
1.1.2 diabetic nephropathy diagnostic criteria: diagnosis all meets ADA's formulation standard in 1997, the diagnostic criteria that is early stage DN is: (1) diabetes medical history, and there is persistence Microalbuminuria (UAER reaches 20～200/ μ g/min or 30～300 mg/d); (2) glomerular filtration rate (GRF) rises more than 20%; (3) conventional UAER detects negative.Except standard: (1) severe hypertension; (2) severe infection or other diseases; (3) used BAOSHENKANG during person; (4) kidney disease of other reasons.
1.1.3 be divided at random three groups: matched group 35 examples, decoction group 33 examples, Capsules group 32 examples.Before three groups of patient treatments, in sex, age, the state of an illness, the course of disease, compare, and difference not statistically significant (P > 0.05), there is comparability.
1.2 method.
1.2.1 Therapeutic Method: three groups of patients all adopt standard diabetes+high-quality Low protein and low phosphorus diet, is strict with less salt and ankyrin, diet control blood glucose and blood pressure treatment, and decoction group adds the 1 gained decoction with embodiment, 2 times/d on matched group medication basis; Capsules group adds described embodiment 3 gained capsule 2g/ time on matched group medication basis, and 2 times/d, totally 30 d.All patients all do not adopt ACEI and/or ARB class Drug therapy and intestinal dialysis, hemodialysis and peritoneal dialysis treatment.
1.2.2 observation item: the front and rear variation of observing three groups of patient's 24 h urine protein quantitation (TP/24 h), glomerular filtration rate (GFR), cholesterol (TC), triglyceride (TG) for the treatment of respectively at treatment, and the variation of ALT, AST.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
The variation of three groups of patient TP/24 h, GFR, TC, TG after 2.1 treatment 30d: see the following form.Result shows: after treating 30 days, the level of the 24 h urine protein quantitation (TP/24 h) of decoction group and Capsules group, glomerular filtration rate (GFR), cholesterol (TC), triglyceride (TG) is treated front obvious reduction (P < 0.05), simultaneously also lower than matched group with time point level (P < 0.05).
2.2 3 groups of adverse reactions of patients incidence rates comparison: decoction group has 15.15%(5/33), Capsules group has 9.38%(3/32) patient occurs that one crosses property diarrhoea, after anti symptom treatment, alleviate, not drug withdrawal.In addition, three groups all there is not obvious adverse reaction record, and before and after treatment, ALT, AST level have no significant change.
3. conclusion.
This result of study shows, take after decoction of the present invention or capsule, diabetic nephropathy patient TP/24 h, GFR, TC, TG are starkly lower than matched group, and there is not obvious adverse reaction record, illustrate that pharmaceutical composition of the present invention is having good effect, the lighter advantage of untoward reaction aspect treatment diabetic nephropathy.
Claims (2)
1. treating diabetes causes and it is characterized in that the pharmaceutical composition of kidney damage being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Fructus Cannabiss, 6 ~ 12 parts of certain herbaceous plants with big flowers colza, 3 ~ 10 parts of Flos Magnoliae Amoenae, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 3 ~ 10 parts of Herba Taxillis, 6 ~ 12 parts of Bulbus Allii Victorialis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Caulis Trachelospermis, 1 ~ 5 part of Cortex erythrinae, 3 ~ 10 parts of Ramulus Cinnamomi, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
2. a kind of pharmaceutical composition that diabetes cause kidney damage for the treatment of according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Fructus Cannabiss, 10 parts of certain herbaceous plants with big flowers colza, 6 parts of Flos Magnoliae Amoenae, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Herba Taxillis, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of Radix Ranunculi Ternatis, 10 parts of Caulis Trachelospermis, 2 parts of Cortex erythrinaes, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310480081.5A CN103520538B (en) | 2013-10-15 | 2013-10-15 | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310480081.5A CN103520538B (en) | 2013-10-15 | 2013-10-15 | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103520538A true CN103520538A (en) | 2014-01-22 |
| CN103520538B CN103520538B (en) | 2015-08-05 |
Family
ID=49923125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310480081.5A Expired - Fee Related CN103520538B (en) | 2013-10-15 | 2013-10-15 | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103520538B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316258A (en) * | 2013-07-01 | 2013-09-25 | *** | Medicine composition for treating infantile vaginitis |
-
2013
- 2013-10-15 CN CN201310480081.5A patent/CN103520538B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 刘越等: "从痰、瘀、毒论治糖尿病肾病", 《浙江中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316258A (en) * | 2013-07-01 | 2013-09-25 | *** | Medicine composition for treating infantile vaginitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103520538B (en) | 2015-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN102343023B (en) | Medicinal composition and preparation method and application thereof | |
| CN103948786B (en) | Traditional Chinese medicine for treating diabetes | |
| CN104208302A (en) | Fructus rosae laevigatae healthy oral solution for reducing blood fat and preparation method thereof | |
| CN104352991A (en) | Traditional Chinese medicine preparation for treating gout and preparation method thereof | |
| CN103041208B (en) | Chinese herbal preparation for treating climacteric syndrome of women, and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN104491342A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN103719495A (en) | Great burdock achene healthcare tea for reducing blood glucose and lipid and preparation method thereof | |
| CN103749824A (en) | Gynostemma pentaphyllum health-care tea capable of lowering blood sugar and blood pressure and preparation method thereof | |
| CN103749819A (en) | Cornus officinalis sieb health-care tea capable of lowering blood sugar and lowering lipid and preparation method of tea | |
| CN103585495B (en) | Capsule for treating diabetic kidney damage | |
| CN104644967A (en) | Pharmaceutical composition for treating I-type diabetes and application thereof | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN103520538B (en) | A kind ofly treat the pharmaceutical composition that diabetes cause kidney damage | |
| CN103495065B (en) | Enema particles for treating diabetic nephropathy and preparation method for enema particles | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN102935214B (en) | Traditional Chinese medicinal composition for treating uremia | |
| CN105311470A (en) | Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN108686094A (en) | A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof | |
| CN104825892B (en) | A kind of Chinese medicine preparation for treating ovulation bleeding and preparation method thereof | |
| CN103735906A (en) | Chinese herb preparation for treating dry bronchiectasis and preparation method thereof | |
| CN103495066B (en) | Enema liquid for treating diabetic nephropathy | |
| CN105943860A (en) | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: LIU YUAN Free format text: FORMER OWNER: SUN XIAOFENG Effective date: 20131223 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Yuan Inventor after: Sun Xiaofeng Inventor after: Zhong Xuewen Inventor before: Sun Xiaofeng Inventor before: Liu Yuan Inventor before: Zhong Xuewen |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SUN XIAOFENG LIU YUAN ZHONG XUEWEN TO: LIU YUAN SUN XIAOFENG ZHONG XUEWEN |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20131223 Address after: 261400 Laizhou people's Hospital, 1817 Wenhua East Road, Yantai, Shandong, Laizhou Applicant after: Liu Yuan Address before: 261400 Laizhou Yantai people's Hospital, 1817 east culture street, Laizhou, Shandong, Shandong Applicant before: Sun Xiaofeng |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 Termination date: 20151015 |
|
| EXPY | Termination of patent right or utility model |