CN103520337A - Traditional Chinese medicinal composition for treating liver cancer - Google Patents

Abstract

The invention provides a traditional Chinese medicinal composition for treating the liver cancer. The traditional Chinese medicinal composition is composed of dry root of Chinese yew, Hedyotis diffusa, Rheum officinale, Vietnamese Sophora Root, Rhizoma Coptidis, Amur Corktree Bark, Barbed Skullcap Herb, Chinese lobelia herb, Phyllanthus virgatus, Caulis Sargentodoxae, Typhonium giganteum Engl., Spica Prunellae, Herba Selaginellae, Hypericum japonicum Thunb. and the like. The traditional Chinese medicinal composition has certain treatment effects on all types of liver cancers.

Description

A kind of Chinese prescription of Hepatoma therapy

Technical field

The invention belongs to tcm field, relate to a kind of Chinese prescription of Hepatoma therapy.

Background technology

Hepatocarcinoma refers to the malignant tumor that betides liver, is one of modal malignant tumor clinically, and according to recent statistics, the annual new liver cancer patient approximately 600,000 in the whole world, occupies the 5th of malignant tumor.Hepatocarcinoma belongs to high morbidity in China, and general male is more than women.China is hepatitis B big country, and how the hepatocarcinoma of China develops on the basis of hbv-liver cirrhosis, and hepatitis C patient also, increasing gradually, also can develop into hepatocarcinoma after hepatitis B.China's number of the infected accounts for the more than half of the whole world at present, accounts for 55% of global hepatocarcinoma patient, has become a large killer of serious threat China people health and lives, and its danger can not look down upon.

Current, operative treatment is still the Main Means of liver cancer treatment.Patient that can operative treatment is only early hepatocarcinoma or small liver cancer, this part patient only accounts for 5%～10% of hepatocarcinoma patient, but after excision, can not solve the removing problem of the interior recurrent focus of liver or Multicentri city, wherein majority merges liver cirrhosis or may have in liver and send out in early days, therefore, most liver cancer patients tend to Drug therapy.

The basic principle of Chinese traditional treatment hepatocarcinoma is dialectical treating, and specific aim is more intense, and the proper symptom that can improve rapidly hepatocarcinoma of medication as pain, heating, abdominal distention, ascites etc., and can be controlled the growth of tumor effectively, and toxic and side effects is little.Chinese medicine is all effective in cure in mid and late liver cancer treatment, and it both can be used as the treatment method of hepatocarcinoma patient, can be used as again the auxiliary treatment medication of operation, radiation, chemotherapy, to improve curative effect, alleviated toxicity, is conducive to excision and postoperative recovery.

Technology contents

The Chinese prescription that the object of this invention is to provide a kind of Hepatoma therapy, this prescription, according to medical material ratio and dose adjustment, all has certain therapeutical effect for various hepatocarcinoma.

The Chinese prescription of Hepatoma therapy of the present invention, is comprised of following active component:

Rattan China fir, Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensis, Rhizoma Coptidis, phellodendron bark, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, yellow pearl, Caulis Sargentodoxae, Herba Typhonii gigantei, Spica Prunellae, Herba Selaginellae, Herba Hyperici Japonici.

The Chinese prescription of Hepatoma therapy of the present invention, the active medical material that it is selected, weight proportion is:

35 parts of rattan China firs, 19 parts of Herba Hedyotidis Diffusaes, 8 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Sophorae Tonkinensiss, 12 parts of Rhizoma Coptidis, 10 parts of phellodendron barks, 22 parts of Herba Scutellariae Barbataes, 14 parts of Herba Lobeliae Chinensis, 7 parts, yellow pearl, 20 parts of Caulis Sargentodoxae, 9 parts of Herba Typhonii gigantei, 10 parts of Spica Prunellaes, 16 parts of Herba Selaginellaes, 14 parts of Herba Hyperici Japonici.

The pharmacological basis of the selected medical herbs of medicament composing prescription of the present invention is:

Rattan China fir is dry root, branch and leaf and the bark of taxaceae plant Ramulus et folium taxi cuspidatae.Its contained composition such as paclitaxel is efficient anticancer component.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature.Nontoxic.Enter the heart, liver, spleen channel.Heat-clearing and toxic substances removing; Dampness removing.Dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at the multiple cancerous protuberance for the treatment of.

Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Return large intestine, liver, spleen channel.Attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.

Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature.Enter the heart, lung, large intestine three warps.Relieve inflammation or internal heat, removing toxic substances, detumescence, pain relieving.Cure mainly retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.

Rhizoma Coptidis: bitter in the mouth, cold in nature, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.For cold and heat, tie mutually damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Phellodendron bark: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity ward off), hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever.

Herba Lobeliae Chinensis: sweet in the mouth, property is flat.GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Cure mainly: venom; Carbuncle furuncle; Tonsillitis; Warm rash; Tinea pedis; Traumatic injury; Jaundice due to damp-heat; Appendicitis; Intestinal is scorching; Nephritis; Cirrhotic ascites and kinds cancer.

Herba Scutellariae Barbatae: acrid in the mouth, hardship; Cold in nature.Return lung, liver, kidney channel.Heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, inducing diuresis to remove edema, analgesic therapy.Cure mainly haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, has sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom." Quanzhou book on Chinese herbal medicine ": heat clearing away, removing toxic substances, dispels the wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; Venom is controlled in external, carbuncle, furuncle, innominate toxic swelling.

Yellow pearl: sweet in the mouth, property is flat.Enter spleen channel.Anti-inflammation, hepatoprotective.

Herba Typhonii gigantei: acrid in the mouth, sweet, warm in nature, poisonous.Return stomach, Liver Channel.Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, detoxicating and resolving stagnation of pathogens pain relieving.

Eye oblique, middle wind-phlegm heap soil or fertilizer over and around the roots in air port in being mainly used to due to wind-phlegm, hemiplegia, tetanus, headache, rheumatic arthralgia, numb limbs and tense tendons, scrofula tuberculosis, carbuncle of yin nature toxic swelling are peppery, venom, infantile convulsion epilepsy, swollen ulcer drug.

Caulis Sargentodoxae: cool in nature, bitter in the mouth is nontoxic.Enter liver, large intestine two warps.The eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide.Control acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.

Spica Prunellae: bitter in the mouth, pungent, cold in nature.Enter liver, gallbladder meridian.Clearing away liver-fire, blood pressure lowering: control hypertension, hyperlipidemia, high blood viscosity and hyperglycemia.Mass dissipating and swelling eliminating: control scrofula, goiter, acute mastitis and swell and ache.

Herba Selaginellae: taste is micro-sweet, property is flat.Clearing away heat and promoting diuresis, promoting blood circulation and detumescence.For acute infectious hepatitis, the contusion of breast side of body waist, anasarca, thrombocytopenia.

Herba Hyperici Japonici: sweet in the mouth, micro-hardship, cold nature.Return liver, spleen channel.Heat-clearing and toxic substances removing, dampness removing jaundice eliminating, detumescence dissipating blood stasis.For jaundice due to damp-heat, acute appendicitis, conjunctival congestion and swelling pain, hot carbuncle toxin; Closely be useful on acute, chronic hepatitis, early stage liver cirrhosis, hepatalgia, appendicitis, mastitis, pulmonary abscess.

The medicament composing prescription of Hepatoma therapy of the present invention, for for oral administration, can decoct and use according to routine, also can according to preparation technique, make according to clinical demand the dosage forms such as corresponding pill, tablet, capsule and powder.

The medicament composing prescription of Hepatoma therapy of the present invention, according to Long-term Clinical Observation, confirms that continuous long-term taking has certain stimulation to stomach, takes continuously 5 days, easily diarrhoea.Treatment administration, is intermittently used.

The Chinese prescription of Hepatoma therapy of the present invention, through fine setting for several times, has formed comparatively clear and definite treatment curative effect.

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Clinical efficacy

1. sample information

Clinical sample is from the out-patient of diagnosis and treatment over several years, total case 27 examples, male 16 examples wherein, female's 11 examples.I phase patient 3 examples, II phase patient 19 examples, III phase patient 5 examples.

2. criterion of therapeutical effect

The method checking about hepatitis B according to national standard, selects serum alpha-fetoprotein (AFP) and liver imaging examination result and criterion.

Alleviate completely: visible tumor disappears and more than lasting January, AFP is down to normal normal level.

Partial rcsponse: two maximum orthogonal diameter products of tumor dwindle more than 50% and more than lasting January, it is normal or a little more than normal level that AFP is down to.

Stable: two maximum orthogonal diameter products of tumor dwindle less than 50%, increase and be no more than 25% and lasting more than one month, AFP is down to constant level.

Worsen: two maximum orthogonal diameter products increases of tumor are no more than 25%, AFP level and do not reduce or raise.3. Therapeutic Method

Therapeutic Method is all to use proportioning Chinese prescription, adopts decoct Oral administration to carry out.According to the state of an illness and course of disease length, determine administration time.Taking is for 5 times a course for the treatment of.According to Long-term Clinical Observation, confirm that continuous long-term taking has certain stimulation to stomach, take continuously 5 days, easily diarrhoea.Treatment administration, is intermittently used.

4. therapeutic outcome

As can be seen from the above table, Chinese prescription of the present invention, for each phase section liver cancer patient, all has curative effect effect.Most patients can control the state of an illness, and and then the effect that obtains alleviating wholly or in part.

5. model case

(1) thank certain, man, 55 years old.Within 2011, suffer from hepatocarcinoma, in Guizhou, the time of little half a year has been treated by the second the People's Hospital, and effect is not too desirable, adds that the economic condition of family is poor, is expectant treatment always, has no improvement, and jaundice, ascites, skin pruritus, be in a bad way.Through friend, introduce here treatment to take this hepatocarcinoma and specially control formula after 5 courses for the treatment of, hepatic ascites, the symptoms such as jaundice have faded away, and the state of an illness is suppressed fast.Rear contact was taken after 11 courses for the treatment of, can take care of oneself and do light work, and removed examination in hospital, and tumor cell inspection, approaches normal value soon.At present in stable recovery.

(2) Deng, man, 35 years old.In other places, do manual work throughout the year, eating is all in building site, and dietary habit is bad at ordinary times, adds and drinks for a long time and smoke, prominent sense chest pain during work in 2009, promptly send treatment to hospital, check as hepatitis B causes the liver cirrhosis of sending out, took medicine for 1 year, bad during fashion, physical weakness, time sense is tired, disability.Take this formula after 9 courses for the treatment of, the state of an illness is alleviated, and has and then taken again 4 courses for the treatment of, and the state of an illness is controlled gradually.

(3) king so-and-so, man, 41 years old.There is chronic hepatitis, liver cirrhosis, a small amount of ascites, in April, 2010, haves a medical check-up and finds two tumors of right lobe of liver because of uncomfortable liver area, and size is 6.5x5.7cm, 3.5x3.0cm, AFP8700ng/L.Operative treatment tumor resection, left hospital rest after two months, and the state of an illness worsens again, check as cancerous cell diffusion, but patient body was weak, cannot carry out second operation.Families of patients is sought medical advice to here, through inquiry medical history and symptom, confirms as chronic hepatitis and causes liver cirrhosis late period, and prescription of the present invention is taken to patient then.After two weeks, patient comes to take medicine again, can freely walk about, and the disappearance of abdominal part ascites, removes examination in hospital, and AFP is down to 2.3ng/l, family's recuperation now, and life can not only be taken care of oneself, and can also participate in the work of the light middle intensity in rural area.

(4) Liu, female, 55 years old.Because of hepatalgia, have a medical check-up and find right liver 7x6cm lump, AFP8200ng/l, slightly higher, be slight hepatocarcinoma.Through taking 4 courses for the treatment of of liver cancer treatment prescription of the present invention, check shows, tumor cell complete inactivation, and postoperative nuclear-magnetism and ultrasonic contrast are without obvious enhancing, and AFP is down to normally, and 3.7ng/l now can be engaged in normal intensity and work.

Specific embodiment

Embodiment mono-

Get and concoct clean 16 grams of 10 grams of 9 grams of 20 grams of 7 grams, 14 grams of 22 grams of 10 grams of 12 grams of 15 grams of 8 grams of 19 grams of 35 grams of dry product rattan China firs, Herba Hedyotidis Diffusaes, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensiss, Rhizoma Coptidis, phellodendron barks, Herba Scutellariae Barbataes, Herba Lobeliae Chinensis, yellow pearl, Caulis Sargentodoxae, Herba Typhonii gigantei, Spica Prunellaes, Herba Selaginellaes, 14 grams of Herba Hyperici Japonici; be placed in marmite; add 2 jin of water; after boiled; slow fire continues to decoct 40 minutes, ceases fire, cooling; elimination medicinal residues, drink.Decoct once every day, divides and take for 2 times, takes continuously and be no more than 3 days.

Embodiment bis-

Get and concoct clean 16 grams of 10 grams of 9 grams of 20 grams of 7 grams, 14 grams of 22 grams of 10 grams of 12 grams of 15 grams of 8 grams of 19 grams of 35 grams of dry product rattan China firs, Herba Hedyotidis Diffusaes, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensiss, Rhizoma Coptidis, phellodendron barks, Herba Scutellariae Barbataes, Herba Lobeliae Chinensis, yellow pearl, Caulis Sargentodoxae, Herba Typhonii gigantei, Spica Prunellaes, Herba Selaginellaes, 14 grams of Herba Hyperici Japonici, be placed in wine tank, add 3 jin of Chinese liquor (42 degree are above for good) to soak more than 15 days, drink each 20～50ml.

Claims (2)

1. a Chinese prescription for Hepatoma therapy, is characterized in that being comprised of following Chinese medicine:

Rattan China fir, Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensis, Rhizoma Coptidis, phellodendron bark, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, yellow pearl, Caulis Sargentodoxae, Herba Typhonii gigantei, Spica Prunellae, Herba Selaginellae, Herba Hyperici Japonici.

2. the Chinese prescription of Hepatoma therapy as claimed in claim 1, its active medical material weight proportion of selecting is:

35 parts of rattan China firs, 19 parts of Herba Hedyotidis Diffusaes, 8 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Sophorae Tonkinensiss, 12 parts of Rhizoma Coptidis, 10 parts of phellodendron barks, 22 parts of Herba Scutellariae Barbataes, 14 parts of Herba Lobeliae Chinensis, 7 parts, yellow pearl, 20 parts of Caulis Sargentodoxae, 9 parts of Herba Typhonii gigantei, 10 parts of Spica Prunellaes, 16 parts of Herba Selaginellaes, 14 parts of Herba Hyperici Japonici.