CN103505477A - Ultramicro blunt powder tablet made of fresh cordyceps and preparation method thereof - Google Patents
Ultramicro blunt powder tablet made of fresh cordyceps and preparation method thereof Download PDFInfo
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- CN103505477A CN103505477A CN201310387003.0A CN201310387003A CN103505477A CN 103505477 A CN103505477 A CN 103505477A CN 201310387003 A CN201310387003 A CN 201310387003A CN 103505477 A CN103505477 A CN 103505477A
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Abstract
A preparation method of an ultramicro blunt powder tablet made of fresh cordyceps comprises the following steps: step 1, washing the collected fresh cordyceps raw materials to remove the soil and mildew; step 2, putting the cordyceps raw materials which have been processed in the step 1 in liquid nitrogen, and pulverizing the raw materials at the temperature of minus 196 DEG C; step 3, drying the pulverized cordyceps raw material under a low pressure, and controlling the water content to be less than 20%; step 4, irradiating the ultramicro powder formed in the step 3 with a cobalt 60 light source, and then pressing the powder into tablets. The method takes the fresh cordyceps medicinal materials collected in a short time as the raw materials, then directly processes the cordyceps raw materials, thus the functions of fresh cordyceps are guaranteed, the biological utilization of activity components in cordyceps is improved; in the absence of any auxiliary materials, the high concentration of cordyceps is guaranteed as much as possible to exert the activity of drugs; the appearance of the prepared tablets is good, the rough-surface rate and cracking-surface rate are low, the hardness, disintegration, and friability of the tablets all meet the quality requirements; the quality is high, and thus the ultramicro blunt powder tablet made of fresh cordyceps and the preparation method thereof have a very important clinical meaning and a resource utilization meaning.
Description
Technical field
The invention belongs to pharmaceutical grade field of health care products, relate in particular to blunt powder sheet of a kind of bright Cordyceps ultra micro and preparation method thereof.
Background technology
Cordyceps (Cordyceps) is section ergot fungus cordyceps sinensis bacterium
cordyceps sinensis(Berk.) Sacc. colonizes in Stroma and the larva cadaveric complex on Hepialidae insect larvae.Be the distinctive a kind of rare natural crude drugs of China, mainly originate in the mesophorbium, coryphile of Qinghai-Tibet height above sea level 3500-5000 rice.Because its market value is higher, while at present Cordyceps being made to tablet, need to mix with other medical materials use or add a large amount of adjuvants.
Invention aweto micropowder tablet of grant number CN100518746C and preparation method thereof is mentioned the preparation method of the pure powder sheet of a kind of Cordyceps, although having realized without adding any adjuvant, the method becomes the tablet of making Cordyceps, but the Cordyceps ultra-micro powder that the method is just 8-18% for moisture, the fresh medical material of not mentioned use, and Chinese Cordyceps is studied the conclusion that the first professor Shen Nanying draws after deliberation: fresh Cordyceps overall efficacy is 3 times of drying drug effect.Drying Cordyceps color brown is obscure simultaneously, and fresh Cordyceps appearance is golden yellow vivid.
Summary of the invention
The object of the present invention is to provide and a kind ofly do not add any adjuvant and surface is vivid, the blunt powder sheet of bright Cordyceps ultra micro that effect promotes greatly and preparation method thereof.
For solving the problems of the technologies described above, the invention provides the blunt powder sheet of a kind of bright Cordyceps ultra micro, by the direct film-making of the fresh Cordyceps of excavating out, obtained.
The preparation method that the present invention further provides the blunt powder sheet of a kind of bright Cordyceps ultra micro, comprises the following steps:
Step 1, the Cordyceps raw material of fresh collection is cleaned to earth, removed mildew;
Step 2, the Cordyceps raw material that step 1 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Step 3, the Cordyceps raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%;
Step 4, the ultra-micro powder that step 3 is formed carry out Co 60 irradiation, and tabletting makes.
The present invention improves to be had, and adopts monotubular eccentric sphere grinding machine to pulverize in described step 2.
The present invention improves to be had, and the low pressure in described step 3 is 20-30KN.
The invention has the beneficial effects as follows: by the manufacture method of novel steps, the Cordyceps medical material of newly excavating directly can be processed as raw material, guaranteed the effect of fresh Cordyceps, improve the bioavailability of Cordyceps active component, do not adding under the situation of any adjuvant, guarantee as far as possible Cordyceps high concentration, the activity of performance medicine, the sheet type outward appearance making is good, pitted skin rate and sliver rate are low, tablet hardness, disintegration, friability meet tablet quality requirement, quality is high, and the meaning of its clinical meaning and the utilization of resources is very great.
The specific embodiment
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, below in conjunction with embodiment and be explained in detail.
The invention provides the blunt powder sheet of bright Cordyceps ultra micro, by the direct film-making of the fresh Cordyceps of excavating out, obtained, by the direct processing of fresh Cordyceps, with respect to drying medical material, its whole drug effect is more than 3 times, and whole outer surface is golden yellow vivid.
The preparation method of the blunt powder sheet of above-mentioned bright Cordyceps ultra micro specifically comprises the following steps:
Step 1, the Cordyceps raw material of fresh collection is cleaned to earth, removed mildew, the Cordyceps raw material after processing exposes golden yellow vivid appearance.
Step 2, the Cordyceps raw material that step 1 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Concrete, during pulverizing, can adopt monotubular eccentric sphere grinder, adopt liquid nitrogen as medium; ambient temperature is controlled at-196 ℃ and pulverizes, the powder of pulverizing gained is thin, good fluidity; be convenient to the direct compression in later stage, and pulverize at low temperature process is conducive to protect the heat-sensitive ingredients in Cordyceps.
Step 3, the Cordyceps raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%;
Step 4, the ultra-micro powder that step 3 is formed carry out Co 60 irradiation, and tabletting makes.
The process of tabletting can adopt repeatedly tabletting etc. further to promote the yield rate of final tablets, is difficult for and occurs loose sheet, shedding, falls the problems such as piece, sliver, loose sheet, and the hardness of tablet also conforms to quality requirements.
The pure powder sheet finally making can guarantee product quality, and product appearance character and hardness meet tablet quality standard-required.Dissolution increases.
The foregoing is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (4)
1. the blunt powder sheet of bright Cordyceps ultra micro, is characterized in that, by the direct film-making of the fresh Cordyceps of excavating out, is obtained.
2. a preparation method for the blunt powder sheet of bright Cordyceps ultra micro, is characterized in that, comprises the following steps:
Step 1, the Cordyceps raw material of fresh collection is cleaned to earth, removed mildew;
Step 2, the Cordyceps raw material that step 1 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Step 3, the Cordyceps raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%;
Step 4, the ultra-micro powder that step 3 is formed carry out Co 60 irradiation, and tabletting makes.
3. the preparation method of the blunt powder sheet of bright Cordyceps ultra micro according to claim 2, is characterized in that, adopts monotubular eccentric sphere grinding machine to pulverize in described step 2.
4. the preparation method of the blunt powder sheet of bright Cordyceps ultra micro according to claim 2, is characterized in that, the low pressure in described step 3 is 20-30KN.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310387003.0A CN103505477A (en) | 2013-08-30 | 2013-08-30 | Ultramicro blunt powder tablet made of fresh cordyceps and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310387003.0A CN103505477A (en) | 2013-08-30 | 2013-08-30 | Ultramicro blunt powder tablet made of fresh cordyceps and preparation method thereof |
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| CN103505477A true CN103505477A (en) | 2014-01-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310387003.0A Pending CN103505477A (en) | 2013-08-30 | 2013-08-30 | Ultramicro blunt powder tablet made of fresh cordyceps and preparation method thereof |
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| CN (1) | CN103505477A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1754557A (en) * | 2004-09-29 | 2006-04-05 | 李义海 | Chinese caterpillar fungus formulation preparation method |
| CN1772007A (en) * | 2005-11-01 | 2006-05-17 | 青海珠峰虫草药业有限公司 | Fermented aweto hypha tablet |
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
-
2013
- 2013-08-30 CN CN201310387003.0A patent/CN103505477A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1754557A (en) * | 2004-09-29 | 2006-04-05 | 李义海 | Chinese caterpillar fungus formulation preparation method |
| CN1772007A (en) * | 2005-11-01 | 2006-05-17 | 青海珠峰虫草药业有限公司 | Fermented aweto hypha tablet |
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘小莉等: "混料设计法优化虫草菌粉含片配方的研究", 《食品科技》 * |
| 张雁等: "无糖人工虫草含片的工艺研究", 《食品工业科技》 * |
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| PB01 | Publication | ||
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Application publication date: 20140115 |