CN103494997B - Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes - Google Patents
Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes Download PDFInfo
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Abstract
The invention relates to traditional Chinese sophora flower medicine treating hyperglycemia and diabetes. The traditional Chinese sophora flower medicine can effectively solve the problem of the treatment and the drug use of the hyperglycemia and the diabetes. According to the technical scheme, the traditional Chinese sophora flower medicine is made of Chinese yams, the roots of kudzu vine and fresh sophora flower, the weight ratio of the Chinese yams to the roots of the kudzu vine is 1:3, the weight ratio of the Chinese yams and the roots of the kudzu vine to the fresh sophora flower is 4:1, and the Chinese yams and the roots of the kudzu vine are smashed into yam and kudzu vine powder; fresh sophora flower is washed with water, the yam and kudzu vine powder is mixed in the washed fresh sophora flower, the fresh sophora flower is covered with the yam and kudzu vine powder, then the fresh sophora flower and the yam and kudzu vine powder are placed in a food steamer to be steamed, pressure reduction and drying are carried out, and finished products are obtained. The traditional Chinese sophora flower medicine is rich in raw material, simple in preparation method, easy to implement, low in cost and convenient to take, has a good hypoglycemic function, is effectively used for treating the hyperglycemia and the diabetes, and is innovation of medicine treating the hyperglycemia and the diabetes.
Description
Technical field
The present invention relates to medicine, particularly a kind of Traditional Chinese sophora flower medicine (precious also known as Flos Sophorae) for the treatment of hyperglycemia and diabetes.
Background technology
Hyperglycemia refers to, when empty stomach (in 8 hours sugar-free and any sugary food intake) blood glucose is higher than normal range, be called hyperglycemia, fasting glucose normal value 4.0-6.1mmol/L, two hours blood glucoses are higher than 7.8mmol/L normal range after the meal, also hyperglycemia can be called, hyperglycemia is not a kind of diagnosis of disease, just a kind of judgement of blood sugar monitoring result, blood sugar monitoring is momentary result, hyperglycemia not exclusively equals diabetes, but easily develops into diabetes, and hyperglycemia drastically influence the healthy of people.
Diabetes to be interacted by environmental factors and inherited genetic factors and what cause take chronic hyperglycemia as the chronic metabolic disease of common trait, domestic to its symptom so-called " hyperglycemia ".Long-term hyperglycemia can cause microvascular endothelial to produce pathological changes, and adjoint protein, lipid metabolism can cause the exception of the organizational structuries such as the heart, brain, kidney, nerve, blood vessel and function extremely, even can cause organ failure and threat to life.Entertaining gives its another name " reticent killer ", and the particularly diabetes of adult type, diabetics on average can reduce by 10 year life-span.And the complication occurred can spread all over whole body, and the complication of diabetes comprises: self-disciplining nervous disorder, neurological disorder, cerebral thrombosis, cerebral infarction.Cataract, decayed tooth, stomatitis, bronchitis, dermatosis, myocardial infarction, uremia, pedopathy change etc.Asia diabetes association reveals, by 2012, the total number of persons of middle national trouble diabetes reached 9,240 ten thousand, and sickness rate is high, can reach 9.7%, and has rejuvenation trend, drastically influence the healthy of people.
At present, though there is the multi-medicament for the treatment of hyperglycemia and diabetes, comprise Chinese medicine and Western medicine, for various reasons, its use is also unsatisfactory, and therefore, the innovation on medicine is the technical problem that people are concerned about very much.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the present invention is just to provide a kind of Traditional Chinese sophora flower medicine for the treatment of hyperglycemia and diabetes, effectively can solve the medicine for treatment problem of hyperglycemia and diabetes.
The technical scheme that the present invention solves is that this Chinese medicine is made up of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and fresh Flos Sophorae, and the weight ratio of RHIIZOMA DIOSCOREAE fr0m Henan of China and Radix Puerariae is 1 ︰ 3, the weight of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and be 4 ︰ 1 with the weight ratio of fresh Flos Sophorae, wherein, RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae are pulverized, becomes mountain Amylum Puerariae Radicis; Fresh Flos Sophorae water is cleaned up, then mountain Amylum Puerariae Radicis is admixed in clean fresh Flos Sophorae, fresh Flos Sophorae is wrapped up by mountain Amylum Puerariae Radicis, is then placed in food steamer and cooks, drying under reduced pressure, be finished product.
Abundant raw material of the present invention, preparation method is simple, and cost is low, taking convenience, has good blood sugar reducing function, is effective to the treatment of hyperglycemia and diabetes, is to treat the innovation on hyperglycemia and diabetes medicament.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
The present invention in the specific implementation, can be realized by following concrete scheme: get 1000 grams, fresh Flos Sophorae, clean up with water; Get RHIIZOMA DIOSCOREAE fr0m Henan of China 1000 grams, Radix Puerariae 3000 grams, pulverize after mixing, cross 100 mesh sieves, obtain mountain Amylum Puerariae Radicis; Mixed thoroughly by fresh Flos Sophorae mountain Amylum Puerariae Radicis after cleaning, fresh Flos Sophorae is wrapped up by mountain Pueraria lobota fine powder, is placed in food steamer and steams 15 minutes, makes fresh Flos Sophorae ripening, by the 60 DEG C of drying under reduced pressure of the Flos Sophorae after ripening, is Flos Sophorae of the present invention precious.
In above-mentioned medicine, wherein:
RHIIZOMA DIOSCOREAE fr0m Henan of China: sweet in the mouth, property is put down, and return spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission; Radix Puerariae: cool in nature, gas is put down, sweet in the mouth, induces sweat and brings down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal; Fresh Flos Sophorae, refer to and just set from Flos Robiniae Pseudoacaciae the edible flower won, also known as fresh Flos Robiniae Pseudoacaciae, bitter in the mouth, cold nature, return liver, large intestine channel; Enter blood to hold back and fall, body slightly falls apart; There is cooling blood for hemostasis, effect of purging liver-fire.
Mutual support between instant component, has effect of good blood sugar lowering, and obtains valid certificates through experiment, and regarding assay data is as follows:
1 experiment material
1.1 Experimental agents
Chinese medicine of the present invention (Flos Sophorae is precious); Metformin hydrochloride, Shanghai Pharmaceutical's letter friendship pharmacy head factory is produced, lot number 110310; Adrenalin hydrochloride injection, Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number 110121; Alloxan, sigma company produces; Streptozotocin, sigma company produces; Normal saline, Zhengzhou Yonghe Pharmaceutical Co produces, lot number 110510; Concentrated sulphuric acid, Luoyang City's chemical reagent factory is produced, lot number 120112; Citric acid (analytical pure), pharmaceuticals of Hubei Province glass station, lot number 120313; Sodium citrate (analytical pure), chemical reagent wholesale department, Tianjin, lot number 120314; Blood sugar kit, Zhejiang Dong Ou biological engineering company limited produces, lot number 120603; Liver glycogen test kit, Nanjing is built up Bioengineering Research Institute and is produced, lot number 120617; Glycated serum protein (GSP) measures test kit, and Nanjing is built up Bioengineering Research Institute first point and produced, lot number 120607.
1.2 laboratory animal
Mice: Kunming kind, SPF level, male, provided by Henan Province's medical experiment animal center, the quality certification number: 008373,008376.
1.3 experimental apparatus
UV-2000 ultraviolet-uisible spectrophotometer: UNICO(Shanghai) Instruments Co., Ltd. produces; Thermostat water bath, bright instrument plant of Beijing produces; Centrifuge, Beijing Medical Instruments repair shop produces; FA (N)/JA (N) series electronic balance, Shanghai Min Qiao precision instrument company limited produces; Adjustable pipette, Shanghai Lei Bo Analytical Instrument Co., Ltd produces.
1.4 test solution preparations
The preparation of citrate buffer: take 1292.4mg citric acid respectively and 1132.3mg sodium citrate is made into 100ml solution, it is 4.2 citrate buffers that this solution is PH, for guaranteeing that its accuracy can with PH instrumental correction allotment.(streptozotocin is very unstable, and comparatively large to vascular stimulation, can alleviate these negative effects with buffer streptozotocin): prepared before use.
The preparation of 10% formalin fixative: 36% formalin 10ml, is made into 100ml with distilled water.
2 experimental techniques
2.1 grouping and administrations
2.1.1 epinephrine is caused to the impact of mice hyperglycemia model
Get male mice 60, body weight 20 ~ 22g, evenly be divided into 6 groups at random, feed contains the processing feedstuff (chow diet of various dose Flos Sophorae treasure respectively, make after adding Flos Sophorae treasure to be respectively 30% containing Flos Sophorae treasure amount, 20%, 10%, normal feeding mice, every day every, mice feed amount was quantitatively 6 grams, fill with 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (every day every, mice feed chow diet amount was 6 grams), model group and blank group gavage the physiological salt liquid (every day every, mice feed chow diet amount was 6 grams) of same volume.Every morning administration 1 time (feedwater), afternoon feed, continuous 9 days.12h after fasting, every Mus rapid lumbar injection epinephrine 240ug/kg except blank group, blank group injection same volume normal saline, after giving epinephrine 30min, 60min immediately eye socket get blood, separation of serum, for survey blood glucose.Then after putting to death mice, liver is taken, homogenate processed, for survey liver glycogen.
2.1.2 alloxan is caused to the impact of mice hyperglycemia model
Feed contains the processing feedstuff (chow diet of various dose Flos Sophorae treasure respectively, make after adding Flos Sophorae treasure to be respectively 30%, 20%, 10% containing Flos Sophorae treasure amount, normal feeding mice, every day every, mice feed amount was quantitatively 6 grams, fill with 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (every day every, mice feed chow diet amount was 6 grams), model group and blank group gavage the physiological salt liquid (every day every, mice feed chow diet amount was 6 grams) of same volume.Every morning administration 1 time (feedwater), afternoon feed, continuous 10 days.90min after 12h perfusion after fasting in the 7th day, every tail vein injection 80mg/kg(0.05ml/10g except blank group) the new alloxan physiological salt liquid prepared, 72h after injection, mouse orbit gets blood, separation of serum, for survey blood glucose.Then after putting to death mice, liver is taken, homogenate processed, for survey liver glycogen.
2.1.3 streptozotocin is caused to the impact of diabetes mice model
Get male mice, normal raising 3 days, after fasting 12h, tail vein injection streptozotocin 80 (mg/kg, 0.02ml/10g), after injection the 11st day fasting 12h, fasting blood sugar is surveyed in afterbody blood sampling, choose blood glucose value >11.1mmol/L and there is obvious polydipsia, polyphagia, the mice of polyuria symptom 50, 5 groups are divided at random by blood glucose value, namely large, in, the precious group of low dose of Flos Sophorae, positive controls and model group, feed contains the processing feedstuff (chow diet of various dose Flos Sophorae treasure respectively, make after adding Flos Sophorae treasure to be respectively 30% containing Flos Sophorae treasure amount, 20%, 10%, normal feeding mice, every day every, mice feed amount was quantitatively 6 grams, fill with 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (mice feed chow diet amount 6 grams every day every), model group gavages the physiological salt liquid (every day every, mice feed chow diet amount was 6 grams) of same volume.Separately get 10 mices as blank group, gavage same volume normal saline (mice feed chow diet amount 6 grams every day every).Every morning administration 1 time (feedwater), afternoon feed, continuous 30 days.Get blood in giving feed the 10th, 20,30 days afterbodys and survey blood glucose value.Within 30th day, after fasting 12h last administration 1h, mouse orbit gets blood, separation of serum, for survey blood glucose.Then after putting to death mice, liver is taken, homogenate processed, for survey liver glycogen; Get pancreas, 10% formalin solution is fixed, and makes pathological section, for om observation pancreatic tissues situation.
2.2 index determining
2.2.1 serum blood sugar level
Mouse orbit gets blood, separation of serum, surveys OD value, by test kit formula scales blood glucose value by test kit description operation.
Agent formulations and concentration
Operational approach
Result calculates: glucose content (nmol/L)=Ar/As × 5.55 (100mg/dL)
Unit conversion: mg/dl × 0.0555=mmol/L
2.2.2 hepatic glycogen content
After eye socket gets blood, put to death mice, get liver, precision takes liver about 50mg, is illustrated in 620nm place surveys each pipe OD value, by test kit formula scales liver glycogen value by liver glycogen test kit.
Sample pretreatment
Sampling: after getting the rinsing of fresh liver normal saline, filter paper blots, and weighs
Hydrolysis: by sample weight (mg): alkali liquor volume (ul)=1:3, adds in test tube together, and boiling water bath boils 20 minutes, flowing water cools.
Glycogen hydrolyzed solution is prepared into further glycogen and detects liquid:
It is 5% that Body development detects liquid, and the amount of adding distil water is: liver weight × 20-liver weight × 4=liver weight × 16
Operation table
Mixing is placed in boiling water boils 5 minutes, and in 620nm wavelength after cooling, 1cm optical path, blank tube returns to zero, and surveys each pipe OD value
Computing formula: extension rate × 10 ÷ 1.11 before glycogen content (mg/g tissue)=mensuration pipe OD value/standard pipe OD value × standard pipe content (0.01mg) × test sample
3 experimental results
3.1 cause the impact of mouse blood sugar level and hepatic glycogen content to epinephrine
By blood sugar kit description and hepatic glycogen test kit description, measure blood sugar level and the hepatic glycogen content of each group of mice respectively, the results are shown in Table 1.
Precious impact epinephrine being caused to mice hyperglycemia model blood sugar level and hepatic glycogen content of table 1 Flos Sophorae
* with model group than P < 0.05, * * with model group than P < 0.01
Can find out from upper table, with blank group ratio, model group significantly raises (P ﹤ 0.01) 30 minutes and 60 minutes blood sugar levels, and liver glycogen level significantly reduces (P ﹤ 0.01), illustrates and makes the success of epinephrine hyperglycemia model.With model group ratio, large, medium and small dosage Flos Sophorae treasure group and metformin group significantly can reduce by 30 minutes blood sugar levels (P ﹤ 0.01), significantly can raise liver glycogen level (P ﹤ 0.01), metformin group can reduce by 60 minutes blood sugar levels (P ﹤ 0.01) by significance, and the precious group of heavy dose of Flos Sophorae obviously can reduce by 60 minutes blood sugar levels (P ﹤ 0.05).
3.2 cause the impact of mouse blood sugar level and hepatic glycogen content to alloxan.
Operate by blood sugar kit description and hepatic glycogen test kit description, measure blood sugar level and the hepatic glycogen content of each group of mice respectively, the results are shown in Table 2.
Precious impact alloxan being caused to mice hyperglycemia model blood sugar level and liver glycogen content of table 2 Flos Sophorae
* with model group than P < 0.05, * * with model group than P < 0.01
Can find out from upper table, with blank group ratio, model group blood sugar level significantly raises (P ﹤ 0.01), and liver glycogen level significantly reduces (P ﹤ 0.01), illustrates and makes the success of mice alloxan hyperglycemia model.With model group ratio, large, medium and small dosage Flos Sophorae treasure group and metformin group significantly can reduce mice alloxan hyperglycemia model sugar level (P ﹤ 0.01), the precious group of dosage Flos Sophorae big or middle significantly can raise liver glycogen level (P ﹤ 0.01), and low dose of Flos Sophorae treasure group and metformin group obviously can raise liver glycogen level (P ﹤ 0.05).
3.3 cause the impact of diabetes mice model blood glucose and pancreatic tissues form to streptozotocin
Operate by blood sugar kit description and hepatic glycogen test kit description, measure blood sugar level and the hepatic glycogen content of each group of mice respectively, the results are shown in Table 3.Om observation pancreatic tissues is cut into slices, and the change of each group pancreas different pathological is in table 4.
Table 3 Flos Sophorae precious on streptozotocin cause diabetes mice model blood sugar level impact (
mmol/l)
* with model group than P < 0.05, * * with model group than P < 0.01
As can be seen from Table 3, with blank group ratio, from be administered into administration the 30th day, model group blood sugar level all significantly raises (P ﹤ 0.01), and liver glycogen level significantly reduces (P ﹤ 0.01), illustrate make mice streptozotocin diabetes model success.Each administration group starts no significant difference between blood glucose, illustrates that grouping evenly; Administration the 10th day, each administration group all reduces than model group, but no significant difference; Administration the 20th day, with model group ratio, metformin group and heavy dose of Flos Sophorae treasure group mouse blood sugar level all significantly reduce (P ﹤ 0.01), and middle dosage Flos Sophorae treasure group obviously reduces (P ﹤ 0.05); Administration the 30th day, with model group ratio, large, medium and small dosage Flos Sophorae treasure group and metformin group all significantly can reduce model mice blood sugar level (P ﹤ 0.01), and low dose of Flos Sophorae treasure group obviously reduces blood sugar level (P ﹤ 0.05); Large, medium and small dosage Flos Sophorae treasure group and metformin group all can remarkable elevation model Mouse Liver glycogen levels (P ﹤ 0.01).
Precious impact streptozotocin being caused to diabetes mice model pancreatic tissues of table 4 Flos Sophorae
"-" islet cells endochylema enriches, and does not occur atrophy, edema and vacuolar degeneration, all normally; "+" islet cells presents atrophy phenomenon, and without edema and vacuolar degeneration; There is atrophy in " ++ " islet cells major part, cell minority occurs edema and without vacuolar degeneration; There is atrophy in " +++ " islet cells, occur edema and the obvious person of vacuolar degeneration simultaneously.
Can find out from upper table, through Ridit inspection, with blank group ratio, the pathological change of model group pancreas significantly (P ﹤ 0.01), illustrates and makes the success of diabetes mice model.With model group ratio, large, medium and small dosage Flos Sophorae treasure group all significantly can alleviate the pathological change (P ﹤ 0.01) of pancreas.Each group of mice pancreatic tissues om observation is visible: blank group Mice Islet Cells endochylema is abundant, cell space is large, islets of langerhans volume is also large; It is intensive that islet cells endochylema in model group mouse islets obviously reduces, cell space reduces, cell seems, islet cells part occurs that cavity becomes; Islet cells part cell cytosol in metformin group mouse islets is abundanter, and part cell cytosol obviously reduces, and cell space obviously reduces, and core is intensive; The most cells of heavy dose of Flos Sophorae treasure group mice pancreatic tissues is restored, and endochylema enriches, and respective cells is edematous state, and around atrophy appears in small part cell; In middle dosage Flos Sophorae treasure group mice pancreatic tissues, part cell presents edematous state, and part is obviously recovered, and endochylema seems abundant, and cell space increases; Islet cells major part in low dose of Flos Sophorae treasure group mice pancreatic tissues presents atrophing state, and cell volume reduces, and core is intensive, and certain atrophy appears in a few cell, but has part endochylema.
Doing zooperal while, the steaming Flos Sophorae being mixed with mountain Amylum Puerariae Radicis is supplied people as steaming dish or suffers from hyperglycemia by applicant, the patient of diabetes eats, every day eats 1-2 time, each 30-60g, people more than 60 edible in, wherein do not suffer from hyperglycemia, diabetes have 21 people, hyperglycemia, each 20 people of diabetics, without finding that there is side effect, and suffer from hyperglycemia, the patient of diabetes is after edible 3 months, hyperglycemia has obvious reduction, diabetic symptom is improved or obviously improves, show to take safety, be conducive to hyperglycemia, the rehabilitation of diabetics and healthy.
4 conclusions
Can clearly be found out by enforcement data, Chinese medicine of the present invention significantly can reduce the blood sugar content of the hyperglycemia mice caused by epinephrine; The hyperglycemia of remarkable reduction alloxan diabetes model mice and streptozotocin-diabetes model mice.Flos Sophorae treasure can also promote that blood glucose is converted into glycogen, significantly improves the content of epinephrine and alloxan diabetes model mice liver glycogen.Flos Sophorae treasure can also improve streptozotocin-diabetes Mice Islet Cells morphology and function, plays good hypoglycemic activity.The precious blood sugar reducing function of Flos Sophorae is with relevant with the size of its dosage on the impact of liver glycogen content.Heavy dose of group is better than middle dosage group, and middle dosage group is better than small dose group.That is along with the increase of dosage, blood sugar reducing function is more obvious, and the increase of liver glycogen content is also more remarkable, presents certain dose-effect relationship.The blood sugar reducing function mechanism of result prompting Flos Sophorae treasure may be that it decomposes hepatic glycogen to antiadrenergic drug; Improve islet cells morphology and function, promote that the beta Cell of islet of animal injury recovers, having actual using value, is the innovation on Chinese medicine.
Claims (2)
1. treat the Traditional Chinese sophora flower medicine of hyperglycemia and diabetes for one kind, it is characterized in that, this Chinese medicine is made up of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and fresh Flos Sophorae, the weight ratio of RHIIZOMA DIOSCOREAE fr0m Henan of China and Radix Puerariae is 1 ︰ 3, the weight of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and be 4 ︰ 1 with the weight ratio of fresh Flos Sophorae, wherein, RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae are pulverized, becomes mountain Amylum Puerariae Radicis; Fresh Flos Sophorae water is cleaned up, then mountain Amylum Puerariae Radicis is admixed in clean fresh Flos Sophorae, fresh Flos Sophorae is wrapped up by mountain Amylum Puerariae Radicis, is then placed in food steamer and cooks, drying under reduced pressure.
2. the Traditional Chinese sophora flower medicine for the treatment of hyperglycemia according to claim 1 and diabetes, is characterized in that, gets 1000 grams, fresh Flos Sophorae, cleans up with water; Get RHIIZOMA DIOSCOREAE fr0m Henan of China 1000 grams, Radix Puerariae 3000 grams, pulverize after mixing, cross 100 mesh sieves, obtain mountain Amylum Puerariae Radicis; Mixed thoroughly by fresh Flos Sophorae mountain Amylum Puerariae Radicis after cleaning, fresh Flos Sophorae is wrapped up by mountain Pueraria lobota fine powder, is placed in food steamer and steams 15 minutes, makes fresh Flos Sophorae ripening, by the 60 DEG C of drying under reduced pressure of the Flos Sophorae after ripening.
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| CN104069384A (en) * | 2014-07-22 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine powder for treating type II diabetes mellitus qi deficiency and blood stasis |
| CN105902761A (en) * | 2016-06-16 | 2016-08-31 | 河南中医学院 | Application of flos sophorae powder in preparing drugs for treating hyperglycemia and diabetes |
| CN105943788A (en) * | 2016-06-16 | 2016-09-21 | 河南中医学院 | Application of sophora flower product in preparation of medicine for treating hyperlipidemia |
| CN117562232B (en) * | 2023-12-08 | 2024-07-05 | 都汇康健(成都)医疗科技有限公司 | Gel preparation and preparation method and application thereof |
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