CN103494997A - Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes - Google Patents
Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes Download PDFInfo
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Abstract
The invention relates to traditional Chinese sophora flower medicine treating hyperglycemia and diabetes. The traditional Chinese sophora flower medicine can effectively solve the problem of the treatment and the drug use of the hyperglycemia and the diabetes. According to the technical scheme, the traditional Chinese sophora flower medicine is made of Chinese yams, the roots of kudzu vine and fresh sophora flower, the weight ratio of the Chinese yams to the roots of the kudzu vine is 1:3, the weight ratio of the Chinese yams and the roots of the kudzu vine to the fresh sophora flower is 4:1, and the Chinese yams and the roots of the kudzu vine are smashed into yam and kudzu vine powder; fresh sophora flower is washed with water, the yam and kudzu vine powder is mixed in the washed fresh sophora flower, the fresh sophora flower is covered with the yam and kudzu vine powder, then the fresh sophora flower and the yam and kudzu vine powder are placed in a food steamer to be steamed, pressure reduction and drying are carried out, and finished products are obtained. The traditional Chinese sophora flower medicine is rich in raw material, simple in preparation method, easy to implement, low in cost and convenient to take, has a good hypoglycemic function, is effectively used for treating the hyperglycemia and the diabetes, and is innovation of medicine treating the hyperglycemia and the diabetes.
Description
Technical field
The present invention relates to medicine, particularly a kind of Flos Sophorae Chinese medicine (claiming again Flos Sophorae treasure) for the treatment of hyperglycemia and diabetes.
Background technology
Hyperglycemia refers to, when (sugar-free and any sugary food intake in 8 hours) blood glucose on an empty stomach higher than normal range, be called hyperglycemia, fasting glucose normal value 4.0-6.1mmol/L, two hours blood glucoses are higher than 7.8mmol/L normal range after the meal, also can be called hyperglycemia, hyperglycemia is not a kind of diagnosis of disease, it is a kind of judgement of blood sugar monitoring result, blood sugar monitoring is momentary result, hyperglycemia not exclusively equals diabetes, but easily develops into diabetes, and hyperglycemia is having a strong impact on the healthy of people.
Diabetes be by environmental factors and inherited genetic factors interact and cause take the chronic metabolic disease that chronic hyperglycemia is common trait, domestic to its symptom so-called " hyperglycemia ".Long-term hyperglycemia can cause microvascular endothelial to produce pathological changes, and the protein of following, lipid metabolism can cause the abnormal of the organizational structure such as the heart, brain, kidney, nerve, blood vessel and function extremely, even can cause the organ failure and threat to life.Entertaining gives its another name " reticent killer ", the particularly diabetes of adult type, and diabetics on average can reduce by 10 year life-span.And the complication occurred can spread all over whole body, and the complication of diabetes comprises: self-disciplining nervous disorder, neurological disorder, cerebral thrombosis, cerebral infarction.Cataract, decayed tooth, stomatitis, bronchitis, dermatosis, myocardial infarction, uremia, pedopathy change etc.Asia diabetes association reveals, by 2012, the total number of persons of middle national trouble diabetes reached 9,240 ten thousand, and sickness rate is high, can reach 9.7%, and rejuvenation trend is arranged, and is having a strong impact on the healthy of people.
At present, though the multi-medicament for the treatment of hyperglycemia and diabetes is arranged, comprise Chinese medicine and Western medicine, for various reasons, it uses and is unsatisfactory, and therefore, the innovation on medicine is the technical problem that people are concerned about very much.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the present invention's purpose just is to provide a kind of Flos Sophorae Chinese medicine for the treatment of hyperglycemia and diabetes, can effectively solve the medicine for treatment problem of hyperglycemia and diabetes.
The technical scheme that the present invention solves is, this Chinese medicine is made by RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and bright Flos Sophorae, and the weight ratio of RHIIZOMA DIOSCOREAE fr0m Henan of China and Radix Puerariae is 1 ︰ 3, the weight of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and with the weight ratio of bright Flos Sophorae be 4 ︰ 1, wherein, RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae are pulverized, become the mountain Amylum Puerariae Radicis; Bright Flos Sophorae water is cleaned up, then the mountain Amylum Puerariae Radicis is admixed in clean bright Flos Sophorae, the mountain Amylum Puerariae Radicis is wrapped up bright Flos Sophorae, then be placed in food steamer and cook, drying under reduced pressure, be finished product.
Abundant raw material of the present invention, preparation method is simple, and cost is low, and taking convenience has good blood sugar reducing function, is effective to the treatment of hyperglycemia and diabetes, is the innovation on treatment hyperglycemia and diabetes medicament.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
In the specific implementation, can be realized by following concrete scheme: get bright Flos Sophorae 1000 grams, water cleans up in the present invention; Get RHIIZOMA DIOSCOREAE fr0m Henan of China 1000 grams, Radix Puerariae 3000 grams, mix rear pulverizing, crosses 100 mesh sieves, obtains the mountain Amylum Puerariae Radicis; Bright Flos Sophorae mountain Amylum Puerariae Radicis after cleaning is mixed thoroughly, and bright Flos Sophorae is wrapped up by mountain Pueraria lobota fine powder, is placed in food steamer and steams 15 minutes, makes bright Flos Sophorae ripening, by 60 ℃ of drying under reduced pressure of the Flos Sophorae after ripening, is Flos Sophorae treasure of the present invention.
In above-mentioned medicine, wherein:
RHIIZOMA DIOSCOREAE fr0m Henan of China: sweet in the mouth, property is flat, returns spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Radix Puerariae: cool in nature, gas is put down, sweet in the mouth, induces sweat and brings down a fever, promotes the production of body fluid, and rash, yang invigorating antidiarrheal; Bright Flos Sophorae, refer to the edible flower of just having won from the Flos Robiniae Pseudoacaciae tree, claims again bright Flos Robiniae Pseudoacaciae, and bitter in the mouth, cold nature, return liver, large intestine channel; Enter blood and hold back and fall, body is slightly loose; There is cooling blood for hemostasis, the effect of purging liver-fire.
Mutual support between component of the present invention, have the effect of good blood sugar lowering, and obtained valid certificates through experiment, and relevant experimental data is as follows:
1 experiment material
1.1 Experimental agents
Chinese medicine of the present invention (Flos Sophorae treasure); Metformin hydrochloride, Shanghai Pharmaceutical's letter friendship pharmacy head factory is produced, lot number 110310; The adrenalin hydrochloride injection, Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number 110121; Alloxan, sigma company produces; Streptozotocin, sigma company produces; Normal saline, Zhengzhou Yonghe Pharmaceutical Co produces, lot number 110510; Concentrated sulphuric acid, Luoyang City's chemical reagent factory is produced, lot number 120112; Citric acid (analytical pure), Hubei Province pharmaceuticals glass station, lot number 120313; Sodium citrate (analytical pure), chemical reagent wholesale department, Tianjin, lot number 120314; Blood sugar kit, east, Zhejiang bowl biological engineering company limited is produced, lot number 120603; The liver glycogen test kit, Nanjing is built up bio-engineering research and is produced, lot number 120617; Glycated serum protein (GSP) is measured test kit, and Nanjing is built up first minute institute of bio-engineering research institute and produced, lot number 120607.
1.2 laboratory animal
Mice: the Kunming kind, the SPF level, male, the quality certification number: 008373,008376 is provided by Henan Province's medical experiment animal center.
1.3 experimental apparatus
The UV-2000 ultraviolet-uisible spectrophotometer: UNICO(Shanghai) Instruments Co., Ltd. produces; Thermostat water bath, the bright instrument plant in Beijing produces; Centrifuge, Beijing Medical Instruments repair shop produces; FA (N)/JA (N) series electronic balance, Shanghai Min Qiao precision instrument company limited is produced; Adjustable pipette, Shanghai Lei Bo Analytical Instrument Co., Ltd produces.
1.4 test solution preparation
The preparation of citrate buffer: take respectively the 1292.4mg citric acid and the 1132.3mg sodium citrate is made into 100ml solution, it is 4.2 citrate buffers that this solution is PH, can be with PH instrumental correction allotment for guaranteeing its accuracy.(streptozotocin is very unstable, and larger to vascular stimulation, with buffer preparation streptozotocin, can alleviate these negative effects): preparation before use.
The preparation of 10% formalin fixative: 36% formalin 10ml is made into 100ml with distilled water.
2 experimental techniques
2.1 grouping and administration
2.1.1 epinephrine is caused to the impact of mice hyperglycemia model
Get 60 of male mices, body weight 20～22g, evenly be divided at random 6 groups, the processing feedstuff that feed contains various dose Flos Sophorae treasure respectively (normal feedstuff, after adding Flos Sophorae treasure, make to be respectively 30% containing the precious amount of Flos Sophorae, 20%, 10%, normal feeding mice, every day, every mice feed amount was quantitatively 6 grams, fill with the 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (every day, every normal forage volume of mice feed was 6 grams), model group and blank group of physiological salt liquid (every day, every normal forage volume of mice feed was 6 grams) that gavages same volume.Every morning administration 1 time (feedwater), afternoon feed, continuous 9 days.12h after fasting, the rapid lumbar injection epinephrine of every Mus 240ug/kg except the blank group, the blank group is injected with the volume normal saline, after giving epinephrine 30min, 60min immediately eye socket get blood, separation of serum, for survey blood glucose.Then after putting to death mice, take liver, homogenate processed, for surveying liver glycogen.
2.1.2 alloxan is caused to the impact of mice hyperglycemia model
The processing feedstuff that feed contains various dose Flos Sophorae treasure respectively (normal feedstuff, after adding Flos Sophorae treasure, make to be respectively 30%, 20%, 10% containing the precious amount of Flos Sophorae, normal feeding mice, every day, every mice feed amount was quantitatively 6 grams, fill with the 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (every day, every normal forage volume of mice feed was 6 grams), model group and blank group of physiological salt liquid (every day, every normal forage volume of mice feed was 6 grams) that gavages same volume.Every morning administration 1 time (feedwater), afternoon feed, continuous 10 days.90min after the 12h perfusion after fasting in the 7th day, every caudal vein injection 80mg/kg(0.05ml/10g except the blank group) the new alloxan physiological salt liquid of preparing, 72h after injection, mouse orbit is got blood, and separation of serum, for surveying blood glucose.Then after putting to death mice, take liver, homogenate processed, for surveying liver glycogen.
2.1.3 streptozotocin is caused to the impact of diabetes mice model
Get male mice, the normal raising 3 days, after fasting 12h, tail vein injection streptozotocin 80 (mg/kg, 0.02ml/10g), after the 11st day fasting 12h of injection, fasting blood sugar is surveyed in the afterbody blood sampling, choose blood glucose value > 11.1mmol/L there is obvious polydipsia, polyphagia, 50 of the mices of polyuria symptom, be divided at random 5 groups by blood glucose value, large, in, the precious group of low dose of Flos Sophorae, positive controls and model group, the processing feedstuff that feed contains various dose Flos Sophorae treasure respectively (normal feedstuff, after adding Flos Sophorae treasure, make to be respectively 30% containing the precious amount of Flos Sophorae, 20%, 10%, normal feeding mice, every day, every mice feed amount was quantitatively 6 grams, fill with the 0.2ml/10g normal saline every day), metformin suspension (0.208g/kg, 0.104mg/ml, 0.2ml/10g) (normal forage volume 6 grams of every mice feed every day), model group gavages the physiological salt liquid (every day, every normal forage volume of mice feed was 6 grams) of same volume.Separately get 10 mices as the blank group, gavage same volume normal saline (normal forage volume 6 grams of every mice feed every day).Every morning administration 1 time (feedwater), afternoon feed, continuous 30 days.Survey blood glucose value in getting blood to the 10th, 20,30 days afterbodys of feed.Within the 30th day, after fasting 12h last administration 1h, mouse orbit is got blood, and separation of serum, for surveying blood glucose.Then after putting to death mice, take liver, homogenate processed, for surveying liver glycogen; Get pancreas, 10% formalin solution is fixed, and does the pathology section, for the om observation pancreas, organizes situation.
2.2 index determining
2.2.1 serum blood sugar level
Mouse orbit is got blood, and separation of serum is pressed the test kit description operation and surveyed the OD value, presses test kit formula conversion blood glucose value.
Reagent composition and concentration
Operational approach
Result is calculated: glucose content (nmol/L)=Ar/As * 5.55 (100mg/dL)
Unit conversion: mg/dl * 0.0555=mmol/L
2.2.2 hepatic glycogen content
After eye socket is got blood, put to death mice, get liver, precision takes liver 50mg left and right, is illustrated in the survey of 620nm place by the liver glycogen test kit and respectively manages the OD value, presses test kit formula conversion liver glycogen value.
Sample pretreatment
Sampling: get fresh liver with after the normal saline rinsing, filter paper blots, and weighs
Hydrolysis: press sample weight (mg): alkali liquor volume (ul)=1:3, add together in test tube, boiling water bath boils 20 minutes, and flowing water is cooling.
The glycogen hydrolyzed solution further is prepared into to glycogen and detects liquid:
It is 5% that liquid detects in inose unit, and the amount of adding distil water is: liver weight * 20-liver weight * 4=liver weight * 16
Operation table
Mix to be placed in boiling water and boil 5 minutes, cooling after in the 620nm wavelength, the 1cm optical path, blank tube zeroing, survey and respectively manage the OD value
Computing formula: extension rate * 10 ÷ 1.11 before glycogen content (mg/g tissue)=mensuration pipe OD value/standard pipe OD value * standard pipe content (0.01mg) * test sample
3 experimental results
3.1 epinephrine is caused to the impact of mouse blood sugar level and hepatic glycogen content
Press blood sugar kit description and hepatic glycogen test kit description, measure respectively blood sugar level and the hepatic glycogen content of respectively organizing mice, the results are shown in Table 1.
Table 1 Flos Sophorae treasure causes the impact of mice hyperglycemia model blood sugar level and hepatic glycogen content on epinephrine
* with model group than P<0.05, * * with model group than P<0.01
From table can find out, with blank group ratio, model group significantly raises (P ﹤ 0.01) 30 minutes and 60 minutes blood sugar levels, the liver glycogen level significantly reduces (P ﹤ 0.01), illustrates and makes the success of epinephrine hyperglycemia model.With the model group ratio, the precious group of large, medium and small dosage Flos Sophorae and metformin group can significantly reduce by 30 minutes blood sugar levels (P ﹤ 0.01), the liver glycogen level that can significantly raise (P ﹤ 0.01), but metformin group significance reduces by 60 minutes blood sugar levels (P ﹤ 0.01), the precious group of heavy dose of Flos Sophorae can obviously reduce by 60 minutes blood sugar levels (P ﹤ 0.05).
3.2 alloxan is caused to the impact of mouse blood sugar level and hepatic glycogen content.
Operated by blood sugar kit description and hepatic glycogen test kit description, measured respectively blood sugar level and the hepatic glycogen content of respectively organizing mice, be the results are shown in Table 2.
Table 2 Flos Sophorae treasure causes the impact of mice hyperglycemia model blood sugar level and liver glycogen content on alloxan
* with model group than P<0.05, * * with model group than P<0.01
From table can find out, with blank group ratio, the model group blood sugar level significantly raises (P ﹤ 0.01), the liver glycogen level significantly reduces (P ﹤ 0.01), illustrates and makes mice alloxan hyperglycemia model success.With the model group ratio, the precious group of large, medium and small dosage Flos Sophorae and metformin group can significantly reduce mice alloxan hyperglycemia model sugar level (P ﹤ 0.01), the precious group of the dosage Flos Sophorae big or middle liver glycogen level (P ﹤ 0.01) that can significantly raise, the precious group of low dose of Flos Sophorae and the metformin group liver glycogen level (P ﹤ 0.05) that can obviously raise.
3.3 streptozotocin is caused to the impact of diabetes mice model blood glucose and pancreas tissue morphology
Operated by blood sugar kit description and hepatic glycogen test kit description, measured respectively blood sugar level and the hepatic glycogen content of respectively organizing mice, be the results are shown in Table 3.Om observation pancreas tissue slice, each is organized the pancreas different pathological and changes in Table 4.
Table 3 Flos Sophorae treasure on streptozotocin cause diabetes mice model blood sugar level impact (
mmol/l)
* with model group than P<0.05, * * with model group than P<0.01
As can be seen from Table 3, with blank group ratio, from starting to be administered into administration the 30th day, the model group blood sugar level all significantly raises (P ﹤ 0.01), and the liver glycogen level significantly reduces (P ﹤ 0.01), illustrates and makes the success of mice streptozotocin diabetes model.Each administration group starts no significant difference between blood glucose, illustrates that grouping evenly; Administration the 10th day, each administration group all reduces than model group, but no significant difference; Administration the 20th day, with the model group ratio, the precious group of metformin group and heavy dose of Flos Sophorae mouse blood sugar level all significantly reduces (P ﹤ 0.01), and the precious group of middle dosage Flos Sophorae obviously reduces (P ﹤ 0.05); Administration the 30th day, with the model group ratio, the precious group of large, medium and small dosage Flos Sophorae and metformin group all can significantly reduce model mice blood sugar level (P ﹤ 0.01), and the precious group of low dose of Flos Sophorae obviously reduces blood sugar level (P ﹤ 0.05); The precious group of large, medium and small dosage Flos Sophorae and metformin group be remarkable elevation model Mouse Liver glycogen level (P ﹤ 0.01) all.
Table 4 Flos Sophorae treasure causes the impact of diabetes mice model pancreas tissue on streptozotocin
"-" islet cells endochylema is abundant, atrophy do not occur, and edema and vacuolar degeneration are all normal; "+" islet cells presents the atrophy phenomenon, and without edema and vacuolar degeneration; Atrophy appears in " ++ " islet cells major part, and the cell minority edema occurs and without vacuolar degeneration; Atrophy appears in " +++" islet cells, the obvious person of edema and vacuolar degeneration occurs simultaneously.
From table can find out, through Ridit check, with blank group ratio, the pathological change of model group pancreas is (P ﹤ 0.01) significantly, illustrate and makes the diabetes mice model successfully.With the model group ratio, the pathological change (P ﹤ 0.01) that the precious group of large, medium and small dosage Flos Sophorae all can significantly alleviate pancreas.Each is organized the mice pancreas and organizes om observation visible: blank group Mice Islet Cells endochylema is abundant, cell space is large, the islets of langerhans volume is also large; It is intensive that islet cells endochylema in the model group mouse islets obviously reduces, cell space dwindles, cell seems, islet cells partly occurs that cavity becomes; Islet cells part cell cytosol in metformin group mouse islets is abundanter, and the part cell cytosol obviously reduces, and cell space obviously dwindles, and core is intensive; The most cells of the precious group of heavy dose of Flos Sophorae mice pancreas tissue is restored, and endochylema is abundant, and indivedual cells are the edema state, and atrophy appears in the small part cell on every side; In the precious group of middle dosage Flos Sophorae mice pancreas tissue, the part cell presents the edema state, and part is obviously recovered, and it is abundant that endochylema seems, cell space increases; Islet cells major part in the precious group of low dose of Flos Sophorae mice pancreas tissue presents atrophing state, and cell volume dwindles, and core is intensive, and certain atrophy appears in a few cell, but the part endochylema is arranged.
Doing the zooperal while, the applicant will be mixed with the steaming Flos Sophorae of mountain Amylum Puerariae Radicis as steaming dish for people or suffering from hyperglycemia, the patient of diabetes is eaten, edible 1-2 time of every day, each 30-60g, in people more than 60 edible, wherein do not suffer from hyperglycemia, diabetes 21 people are arranged, hyperglycemia, each 20 people of diabetics, without finding that there is side effect, and suffers from hyperglycemia, the patient of diabetes is after edible 3 months, hyperglycemia has obvious reduction, diabetic symptom is improved or obviously improves, show to take safety, be conducive to hyperglycemia, the rehabilitation of diabetics and healthy.
4 conclusions
By the enforcement data, can clearly be found out, Chinese medicine of the present invention can significantly reduce the blood sugar content of the hyperglycemia mice due to epinephrine; Significantly reduce the hyperglycemia of alloxan diabetes model mice and streptozotocin-diabetes model mice.Flos Sophorae treasure can also promote that blood glucose is converted into glycogen, significantly improves the content of epinephrine and alloxan diabetes model mice liver glycogen.Flos Sophorae treasure can also improve streptozotocin-diabetes Mice Islet Cells morphology and function, brings into play good hypoglycemic activity.The precious blood sugar reducing function of Flos Sophorae is relevant with the size of its dosage with the impact on liver glycogen content.Heavy dose of group is better than middle dosage group, and middle dosage group is better than small dose group.That is to say the increase along with dosage, blood sugar reducing function is just more obvious, and the increase of liver glycogen content is also more remarkable, presents certain dose-effect relationship.Results suggest Flos Sophorae treasure's blood sugar reducing function mechanism may be that it decomposes hepatic glycogen to antiadrenergic drug; Improving the islet cells morphology and function, promote the beta Cell of islet of animal injury to recover, actual using value is arranged, is the innovation on Chinese medicine.
Claims (2)
1. a Flos Sophorae Chinese medicine for the treatment of hyperglycemia and diabetes, it is characterized in that, this Chinese medicine is made by RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and bright Flos Sophorae, the weight ratio of RHIIZOMA DIOSCOREAE fr0m Henan of China and Radix Puerariae is 1 ︰ 3, the weight of RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae and with the weight ratio of bright Flos Sophorae be 4 ︰ 1, wherein, RHIIZOMA DIOSCOREAE fr0m Henan of China, Radix Puerariae are pulverized, become the mountain Amylum Puerariae Radicis; Bright Flos Sophorae water is cleaned up, then the mountain Amylum Puerariae Radicis is admixed in clean bright Flos Sophorae, the mountain Amylum Puerariae Radicis is wrapped up bright Flos Sophorae, then be placed in food steamer and cook, drying under reduced pressure.
2. the Flos Sophorae Chinese medicine for the treatment of hyperglycemia according to claim 1 and diabetes, is characterized in that, gets bright Flos Sophorae 1000 grams, and water cleans up; Get RHIIZOMA DIOSCOREAE fr0m Henan of China 1000 grams, Radix Puerariae 3000 grams, mix rear pulverizing, crosses 100 mesh sieves, obtains the mountain Amylum Puerariae Radicis; Bright Flos Sophorae mountain Amylum Puerariae Radicis after cleaning is mixed thoroughly, and bright Flos Sophorae is wrapped up by mountain Pueraria lobota fine powder, is placed in food steamer and steams 15 minutes, makes bright Flos Sophorae ripening, by 60 ℃ of drying under reduced pressure of the Flos Sophorae after ripening.
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Cited By (5)
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| CN103768335A (en) * | 2014-02-25 | 2014-05-07 | 牛正华 | Carbohydrase-like tea powder electuary with treatment and health-care effects on diabetes |
| CN104069384A (en) * | 2014-07-22 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine powder for treating type II diabetes mellitus qi deficiency and blood stasis |
| CN105902761A (en) * | 2016-06-16 | 2016-08-31 | 河南中医学院 | Application of flos sophorae powder in preparing drugs for treating hyperglycemia and diabetes |
| CN105943788A (en) * | 2016-06-16 | 2016-09-21 | 河南中医学院 | Application of sophora flower product in preparation of medicine for treating hyperlipidemia |
| CN117562232A (en) * | 2023-12-08 | 2024-02-20 | 都汇康健(成都)医疗科技有限公司 | Gel preparation and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103768335A (en) * | 2014-02-25 | 2014-05-07 | 牛正华 | Carbohydrase-like tea powder electuary with treatment and health-care effects on diabetes |
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| CN105902761A (en) * | 2016-06-16 | 2016-08-31 | 河南中医学院 | Application of flos sophorae powder in preparing drugs for treating hyperglycemia and diabetes |
| CN105943788A (en) * | 2016-06-16 | 2016-09-21 | 河南中医学院 | Application of sophora flower product in preparation of medicine for treating hyperlipidemia |
| CN117562232A (en) * | 2023-12-08 | 2024-02-20 | 都汇康健(成都)医疗科技有限公司 | Gel preparation and preparation method and application thereof |
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| CN103494997B (en) | 2015-05-06 |
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