CN103494889B - Traditional Chinese medicine for treating chilblain and preparation method thereof - Google Patents
Traditional Chinese medicine for treating chilblain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating chilblain and a preparation method thereof. The traditional Chinese medicine comprises corydalis thalictrifolia, Chinese ephedra, cassia twig, radices sileris, tenuifolia and flowers carthami. The traditional Chinese medicine disclosed by the invention is good in curative effect on the chilblain and free of toxic and side effects. Process optimization is also carried out; the optimized process adopts a clarifying agent treatment process; excessive water resource waste is avoided; technological parameters are clear, so that the stability of the prepared product is greatly improved; the variety and the dosage of auxiliary materials are clear; the quality of the finally prepared and molded product is improved; the uniformity of the quality of a plurality of batches of products is ensured.
Description
Technical field
The present invention relates to biomedicine field, be specifically related to a kind of Chinese medicine for the treatment of chilblain and preparation method thereof.
Background technology
Chilblain refers to that human body is damaged by the caused general of it is attacked by the cold and evil or locality.Chilblain is caused because of cold weather, mostly occurs and locates in end, nose, buccal and the ear etc. of trick.Illing skin is pale, rubescent, edema, the burning pain of itching, and has swelling sense.The serious purple blood blister that occurs causes affected part necrosis, the pain of suppurating of festering.It is lighter that locality is frozen the wounded's state of an illness, with local swelling, numbness, sufferings, livid purple, or plays vesicle, and very to become skin ulcer be main to ulceration.
Chinese patent, title: " treating Chinese medicine preparation and production method thereof slight, severe chilblain ", number of patent application: " 201110195170.6 ".This patent discloses a kind of treat Chinese medicine preparation and production method thereof slight, severe chilblain, its formula is " Pericarpium Zanthoxyli 15～30, Ramulus Cinnamomi 15～30, the Radix Rehmanniae 15～30, Flos Carthami 3～10, Radix Sanguisorbae 15～30, Galla Chinensis 8～15 ", what its production technology adopted is traditional water extraction concentration technology, product stability is poor, in put procedure, constantly there is Precipitation, cause in solution precipitate too much, unfavorable patient uses, and has also affected greatly the stable of product; And its process route is more extensive, adjuvant does not have concrete classification yet, and technological parameter is also not enough, is unfavorable for the concordance of quality between multiple batches of product.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of chilblain and preparation method thereof, this Chinese medicine has overcome the defect of prior art, has good curative effect, and its preparation method is scientific and reasonable, the active component good stability of making.
The Chinese medicine for the treatment of chilblain of the present invention is to be prepared from by the raw material that comprises following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 20-50 Herba Ephedrae 15-40 Ramulus Cinnamomi 15～40
Radix Saposhnikoviae 10-30 Herba Schizonepetae 10-30 Flos Carthami 3～10.
Preferably, the Chinese medicine of described treatment chilblain is to be prepared from by the raw material that comprises following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 30-40 Herba Ephedrae 15-25 Ramulus Cinnamomi 20～30
Radix Saposhnikoviae 10-20 Herba Schizonepetae 10-20 Flos Carthami 4～8.
Further preferably, it is to be prepared from by the raw material that comprises following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 30 Herba Ephedrae 15 Ramulus Cinnamomi 20
Radix Saposhnikoviae 15 Herba Schizonepetae 15 Flos Carthamis 5.
The Chinese medicine of described treatment chilblain, its active component is prepared from by the following method:
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extracting in water twice, adds the water of 8～12 times of medical material gross weights for the first time, extracts 1～3 hour, filter, add for the second time the water of 8～12 times of medical material gross weights, extract 1～2 hour, filter, merge filtrate twice, be concentrated into 2～3 times of medical material gross weight, filter, obtain solution 3;
(3), solution 3 is heated to 70～90 DEG C, add and be equivalent to the solution 2 that the percentage by weight of solution 3 gross weights is 4%～8%, stir, then stirred once every 20～30 minutes, after 2～4 hours, adding the percentage by weight that is equivalent to solution 3 gross weights is 1%～4% solution 1, stir, leave standstill 2～4 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
The Chinese medicine of described treatment chilblain, its active component is to be prepared from by following method for optimizing:
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, add for the first time the water of 10 times of medical material gross weights, extract 2 hours, filter, add for the second time the water of 8 times of medical material gross weights, extract 1 hour, filter, merge twice filtrate, be concentrated into 3 times of medical material gross weight, filter, obtain solution 3;
(3), solution 3 is heated to 70 DEG C, add and be equivalent to the solution 2 that the percentage by weight of solution 3 gross weights is 6%, stir, then stirred once every 20 minutes, after 3 hours, adding the percentage by weight that is equivalent to solution 3 gross weights is 3% solution 1, stir, leave standstill 3 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
The Chinese medicine of described treatment chilblain, its liniment is prepared from by following technique:
Active component is diluted with water to 8～12 times of medical material total amount, filters, add and be equivalent to the potassium sorbate that the percentage by weight of filtrate total amount is 0.3%～0.6%, be filled to medicine bottle or spray bottle, sterilizing, obtains described liniment.
The Chinese medicine of described treatment chilblain, its unguentum is prepared from by following technique:
It is 1.30～1.35 thick paste that active component is concentrated into relative density, filter, add and be equivalent to the carbomer solution that 20%～30% percentage by weight of thick paste weight is 4%, be heated to 50～70 DEG C, stir, then add 0.8～2% the laurocapram that is equivalent to thick paste weight, stir, obtain described unguentum.
The Chinese medicine for the treatment of chilblain of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various preparations.
ZTCI+1 natural clarifying agent of the present invention is market existing procucts, sells such as just there is this product in Beijing Zheng Tiancheng clarification technique company limited.
In the present invention, Chinese medicine details is as follows:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae)
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (formal name used at school: Corydalis saxicola Bunting) belongs to Papaverales Papaveraceae, herbaceos perennial.High 15-40cm.Main root prosperity.Be born in the border rock slot of mountain region, have distribution at south China more.Function heat-clearing and toxic substances removing; Dampness removing; Analgesic hemostatic; Cure mainly hepatitis; Aphthous stomatitis; Acute catarrhal conjunctivitis; Corneal nebula; Dysentery; Diarrhoea; Stomachache; Bleeding hemorrhoids.
Herba Ephedrae
This product is the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf. epheday intermedia Ephedra intermedia Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge..Tap green herb stem autumn, dry.Acrid in the mouth, micro-hardship, warm in nature.Return lung, urinary bladder channel.Function diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema.Honey Herba Ephedrae nourishing the lung to arrest cough.Be used for exterior syndrome and separate, asthma and cough.
Ramulus Cinnamomi
This product is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.Acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Saposhnikoviae
This product is umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata(Turcz.) dry root of Schischk..Spring, Qiu Erji excavate the root of not taking out scape plant. and remove fibrous root and silt, dry.Taste: pungent, sweet, warm in nature.Return bladder, liver, spleen channel.Function inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold. rheumatic arthralgia, rubella pruritus, tetanus.
Herba Schizonepetae
This product is the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Acrid in the mouth, slightly warm in nature.Return lung, Liver Channel.The function loose wind that induces sweat, rash, for flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Flos Carthami
This product is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Pluck when flower is red by xanthochromia summer, dries in the shade or dry.Acrid in the mouth, warm in nature.GUIXIN, Liver Channel.Function promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, addiction abdominal mass mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) function heat-clearing and toxic substances removing, dampness removing in the present invention, Herba Ephedrae function inducing diuresis to remove edema, two medicines share gather altogether detumescence detoxification effect, be monarch drug altogether; Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, wind-shielding function inducing diaphoresis to dispel wind, is ministerial drug altogether; Assistant Flos Carthami function promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, is adjuvant drug; All medicines share, the detoxification that gathers altogether detumescence, the effect restoring menstrual flow and invigorating blood circulation.Pharmaceutical formulation of the present invention combines reasonable science, and treatment chilblain has good curative effect.
Verify through embodiments of the invention 6, traditional Chinese medicine composition for treating mild chilblain success rate provided by the invention is higher than 98%, and curing severe chilblain also has the therapeutic effect that exceedes 90%, has very good effect.
The present invention has also optimized extraction process, has avoided unnecessary water resource waste, has adopted clarifier treatment process, and clear and definite technological parameter, greatly promotes the product stability of making.
Inventor selects through test of many times, clear and definite supplementary product kind and consumption thereof, optimized the preparation technology of liniment and unguentum, chosen the best preparation technology of effect, make the product quality of finally preparing molding obtain lifting, and ensured the homogeneity between multiple batches of product quality.
Detailed description of the invention
Embodiment 1
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 200g Herba Ephedrae 150g Ramulus Cinnamomi 150g
Radix Saposhnikoviae 100g Herba Schizonepetae 100g Flos Carthami 30g
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extract twice, add for the first time the water of 5840g, extracts 1 hour, filter, add for the second time the water of 5840g, extracts 1 hour, filtration, merges twice filtrate, is concentrated into 1460g, and filtration, obtains solution 3;
(3), solution 3 is heated to 70 DEG C, add the solution 2 of 58.4g, stir, then stirred once every 20 minutes, after 2 hours, add the solution 1 of 20.2g, stir, leave standstill 2 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component.
Embodiment 2
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 500g Herba Ephedrae 400g Ramulus Cinnamomi 400g
Radix Saposhnikoviae 300g Herba Schizonepetae 300g Flos Carthami 100g
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extract twice, add for the first time the water of 24000g, extracts 1 hour, filter, add for the second time the water of 24000g, extracts 1 hour, filtration, merges twice filtrate, is concentrated into 4350g, and filtration, obtains solution 3;
(3), solution 3 is heated to 90 DEG C, add the solution 2 of 348g, stir, then stirred once every 20 minutes, after 2 hours, add the solution 1 of 174g, stir, leave standstill 2 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
(4), active component is diluted with water to 11600g, filter, add the potassium sorbate of 348g, be filled to medicine bottle or spray bottle, sterilizing, obtains described liniment.
Embodiment 3
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 300g Herba Ephedrae 150g Ramulus Cinnamomi 200g
Radix Saposhnikoviae 150g Herba Schizonepetae 150g Flos Carthami 50g
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extract twice, add for the first time the water of 10000g, extracts 1 hour, filter, add for the second time the water of 8000g, extracts 1 hour, filtration, merges twice filtrate, is concentrated into 3000g, and filtration, obtains solution 3;
(3), solution 3 is heated to 90 DEG C, add the solution 2 of 180g, stir, then stirred once every 20 minutes, after 2 hours, add the solution 1 of 100g, stir, leave standstill 2 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
(4), active component is diluted with water to 9500g, filter, add the potassium sorbate of 380g, be filled to medicine bottle or spray bottle, sterilizing, obtains described liniment.
Embodiment 4
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 300g Herba Ephedrae 250g Ramulus Cinnamomi 300g
Radix Saposhnikoviae 200g Herba Schizonepetae 200g Flos Carthami 80g
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extract twice, add for the first time the water of 11970g, extracts 1 hour, filter, add for the second time the water of 14630g, extracts 1 hour, filtration, merges twice filtrate, is concentrated into 2130g, and filtration, obtains solution 3;
(3), solution 3 is heated to 90 DEG C, add the solution 2 of 207g, stir, then stirred once every 20 minutes, after 2 hours, add the solution 1 of 207g, stir, leave standstill 2 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
(4) it is 1.32 thick paste that the active component, above method being prepared into is concentrated into relative density, filter, add and be equivalent to the carbomer solution that 20% percentage by weight of thick paste weight is 4%, be heated to 50 DEG C, stir, then add 0.8% the laurocapram that is equivalent to thick paste weight, stir, obtain described unguentum.
Embodiment 5
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 360g Herba Ephedrae 180g Ramulus Cinnamomi 250g
Radix Saposhnikoviae 180g Herba Schizonepetae 180g Flos Carthami 50g
(1), to be mixed with weight ratio concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight ratio concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extract twice, add for the first time the water of 13200g, extracts 1 hour, filter, add for the second time the water of 14400g, extracts 1 hour, filtration, merges twice filtrate, is concentrated into 2900g, and filtration, obtains solution 3;
(3), solution 3 is heated to 90 DEG C, add the solution 2 of 203g, stir, then stirred once every 20 minutes, after 2 hours, add the solution 1 of 87g, stir, leave standstill 2 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component;
(4) it is 1.31 thick paste that the active component, above method being prepared into is concentrated into relative density, filter, add and be equivalent to the carbomer solution that 25% percentage by weight of thick paste weight is 4%, be heated to 60 DEG C, stir, then add 1.2% the laurocapram that is equivalent to thick paste weight, stir, obtain described unguentum.
Embodiment 6
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 360g Herba Ephedrae 180g Ramulus Cinnamomi 250g
Radix Saposhnikoviae 180g Herba Schizonepetae 180g Flos Carthami 50g
Whole pulverizing medicinal materials are become to fine powder, after water is moistening, add fomentation in affected part.
Embodiment 7
1 medicine
Embodiment group: use embodiment 3 liniments, 2 times on the one, each 5-10ml.
2 case selections
Mild chilblain 40 examples
Severe chilblain 20 examples
3 observed results
3.1 criterion of therapeutical effect
Cure: redness or diabrosis place disappear, pruritus disappears, and it is normal that the affected part colour of skin is recovered;
Take a turn for the better: redness or diabrosis place are disappeared, and pruritus obviously alleviates;
Invalid: symptom, sign are without improvement.
3.2 therapeutic outcomes are in table 1.
Table 1 liang group curative effect comparison
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Effective percentage |
| Slight group | 40 | 40 | ? | ? | >99% |
| Severe group | 20 | 17 | 2 | 1 | 95% |
Result shows: traditional Chinese medicine composition for treating mild chilblain success rate provided by the invention is higher than 98%, and curing severe chilblain also has the therapeutic effect that exceedes 90%.The present invention has the effect of good healing chilblain.
Embodiment 7
Product under technique of the present invention carries out stability contrast, leaves standstill and investigates with room temperature, investigates and the results are shown in Table 2:
Product stability under table 2 technique of the present invention is investigated result
| Product | 1 month | 2 months | 3 months |
| Active component of the present invention | Clarification, deposit-free | Clarification, deposit-free | Clarification, bottom has microprecipitation thing |
| Liniment of the present invention | Clarification, deposit-free | Clarification, deposit-free | Clarification, deposit-free |
| Unguentum of the present invention | Clarification, deposit-free | Clarification, deposit-free | Clarification, deposit-free |
Embodiment 8
1, Liuzhou beam, man, 30 years old, in January, 2012 was medical, chilblain on foot, red and swollen pruritus is serious, smears skin with embodiment 1 medicine, and medication every day is fully recovered for twice, 3 day afterwards, no sequel.
2, Liuzhou Zhang, female, 42 years old, in February, 2012 was medical, and trick is long chilblain all, and red and swollen pruritus is serious, smears skin with embodiment 4 medicines, and medication every day is fully recovered for twice, 3 day afterwards, no sequel.
3, Liuzhou Wang, man, 38 years old, in February, 2012 was medical, and trick is long chilblain all, and red and swollen pruritus is serious, smears skin with embodiment 2 medicines, and medication every day is fully recovered for twice, 2 day afterwards, no sequel.
4, Liuzhou Huang, female, 55 years old, in February, 2012 was medical, and trick is long chilblain all, and red and swollen pruritus is serious, has slight diabrosis, smears skin with embodiment 5 medicines, and medication every day is fully recovered for twice, 4 day afterwards, no sequel.
5, certain is thanked in Liuzhou, man, and 35 years old, in February, 2012 was medical, pushing chilblain, red and swollen pruritus is serious, with embodiment 6 medicine hot compress, medication every day recovery from illness afterwards in twice, 5 day, no sequel.
Claims (8)
1. treat a Chinese medicine for chilblain, it is characterized in that it is to be prepared from by the raw material of following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 20-50 Herba Ephedrae 15-40 Ramulus Cinnamomi 15～40
Radix Saposhnikoviae 10-30 Herba Schizonepetae 10-30 Flos Carthami 3～10.
2. the Chinese medicine for the treatment of chilblain as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 30-40 Herba Ephedrae 15-25 Ramulus Cinnamomi 20～30
Radix Saposhnikoviae 10-20 Herba Schizonepetae 10-20 Flos Carthami 4～8.
3. the Chinese medicine for the treatment of chilblain as claimed in claim 2, is characterized in that it is to be prepared from by the raw material of following weight portion:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 30 Herba Ephedrae 15 Ramulus Cinnamomi 20
Radix Saposhnikoviae 15 Herba Schizonepetae 15 Flos Carthamis 5.
4. the Chinese medicine for the treatment of chilblain as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
, to be mixed with weight percent concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight percent concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, extracting in water twice, adds the water of 8～12 times of medical material gross weights for the first time, extracts 1～3 hour, filter, add for the second time the water of 8～12 times of medical material gross weights, extract 1～2 hour, filter, merge filtrate twice, be concentrated into 2～3 times of medical material gross weight, filter, obtain solution 3;
(3), solution 3 is heated to 70～90 DEG C, add the solution 2 that is equivalent to solution 3 gross weights 4%～8%, stir, then stirred once every 20～30 minutes, after 2～4 hours, add the solution 1 that is equivalent to solution 3 gross weights 1%～4%, stir, leave standstill 2～4 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component.
5. the Chinese medicine for the treatment of chilblain as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
, to be mixed with weight percent concentration be 1% solution for the A component water of getting ZTCI+1 natural clarifying agent, obtains solution 1, it is 1% solution that B component is mixed with weight percent concentration with 1% acetic acid, obtains solution 2;
(2), whole pulverizing medicinal materials are become to coarse powder, add for the first time the water of 10 times of medical material gross weights, extract 2 hours, filter, add for the second time the water of 8 times of medical material gross weights, extract 1 hour, filter, merge twice filtrate, be concentrated into 3 times of medical material gross weight, filter, obtain solution 3;
(3), solution 3 is heated to 70 DEG C, add the solution 2 that is equivalent to solution 3 gross weights 6%, stir, then stirred once every 20 minutes, after 3 hours, add the solution 1 that is equivalent to solution 3 gross weights 3%, stir, leave standstill 3 hours, high speed centrifugation, sediment separate out, gets supernatant and obtains described active component.
6. the Chinese medicine of the treatment chilblain as described in claim 4 or 5, is characterized in that, its liniment is prepared from by following technique:
Active component is diluted with water to 8～12 times of medical material total amount, filters, add the potassium sorbate that is equivalent to filtrate gross weight 0.3%～0.6%, be filled to medicine bottle or spray bottle, sterilizing, obtains described liniment.
7. the Chinese medicine of the treatment chilblain as described in claim 4 or 5, is characterized in that, its unguentum is prepared from by following technique:
It is 1.30～1.35 thick paste that active component is concentrated into relative density, filter, add and be equivalent to the carbomer solution that 20%～30% percentage by weight of thick paste weight is 4%, be heated to 50～70 DEG C, stir, then add 0.8%～2% the laurocapram that is equivalent to thick paste weight, stir, obtain described unguentum.
8. treat a Chinese medicine preparation for chilblain, prepare and form by the Chinese medicine of the treatment chilblain described in any one in claim 1～5 and pharmaceutically acceptable carrier.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1051241C (en) * | 1995-03-25 | 2000-04-12 | 徐月侠 | Dongchuangling liniment for chilblain |
| JP2004115483A (en) * | 2002-09-30 | 2004-04-15 | Ogawa & Co Ltd | Moisture retention vegetable extract and moisture retention agent for external use, cosmetic, bathing agent and detergent composition each containing the extract |
| JP2004115484A (en) * | 2002-09-30 | 2004-04-15 | Ogawa & Co Ltd | Moisture retention vegetable extract and moisture retention agent for external use, cosmetic, bathing agent and detergent composition each containing the extract |
| CN101049490A (en) * | 2007-05-11 | 2007-10-10 | 陈江 | Chilblain soup containing angelica sinensis and folium artemisiae argyi |
| CN101084962A (en) * | 2007-06-18 | 2007-12-12 | 云南植物药业有限公司 | Adsorption clarification method in preparing notoginseng total saponins |
| CN102048847A (en) * | 2009-11-09 | 2011-05-11 | 陈登 | Externally applied medicine for treating frostbite |
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