CN103494887A - Chinese medicine composition for treating knee arthritis and preparation method thereof - Google Patents
Chinese medicine composition for treating knee arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for treating knee arthritis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. According to the Chinese medicine composition, active components are prepared from the following traditional Chinese medicinal materials: honeysuckle stem, hematoxylon, lanceolate jasmine root, rhizoma bolbostemmae, galeola faberi, tripterygium hypoglaucum, pilea plataniflora and mallow leaves as raw materials in combination; the active components and auxiliary materials of a common pharmaceutic preparation are prepared into Chinese medicine tablets, granules and capsules. The Chinese medicine composition has an accurate therapeutical effect on the knee arthritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of gonarthritis and preparation method thereof, belong to technical field of Chinese medicines.
Technical background
Gonarthritis is the common arthrosis that the articular cartilage degenerative disease becomes feature, and this illness is to take the chronic disease that the Secondary cases hyperosteogeny is pathological characters under edge, joint, cartilage, is the common joint property illness of person in middle and old age, even can cause deformity; It is cardinal symptom that gonarthritis be take the gonalgia, stiff, dysfunction, and the articular cartilage of take is carried out sexual involution as main clinical characters, and this illness has chronic evolution, relevant with factors such as age, sex, body weight; Modern medicine there is no with regard to this illness treatment the method for blocking knee osteoarthritis pathology progress fully, such illness is a kind of common autoimmune disease, and pathological changes joint main manifestations is inflammatory cell infiltration, synovial hyperplasia, pannus forms, and causes thus cartilage and bone injury.
Knee has many synovial bursas relevant with the tendon slide construction with joint motion, what have communicates with joint, the isolated existence had, the most ill synovial bursa is prepatellar bursa, under kneecap, synovial bursa gastrocnemius, knee suffer long-term external force matcha or compressing, all can cause synovial membrane hyperemia, and edema and serosity ooze out, form acute synovial bursa hydrops, cause cyst wall to thicken and the pathological changes such as joint accretion.The synovial bursa layer blood fortune of gonarthritis is abundant, and distribution is larger, is one of kneed important structure.The synovial cell can secrete synovial fluid, keeps the lubricated of articular surface.Mostly the generation of gonarthromeningitis be due to the knee joint acute injury, or the synovial membrane aseptic inflammation caused due to chronic strain, hyperosteogeny and rheumatism factor.
Gonarthritis is a kind of chronic joint disease that articular cartilage degeneration and Secondary cases hyperosteogeny be feature of take, be more common in middle-aged and elderly people, the women, more than the male, is apt to occur in the knee joint position that burden is larger, and its genesis is a kind of long-term, chronic, progressive pathological process, clinical cardinal symptom is pain, initial stage is slight dull pain, progressively aggravation later, and it is movable that the pain increased when many, after having a rest, take a turn for the better, pain can be relevant with factors such as weather, humidity, activities; When hydrops is arranged, the floating patella test positive can appear in knee joint, and joint deformity appears in severe patient; The visible soft tissue swelling of x-ray inspection, joint space narrows down in various degree, and the edge, joint has hyperosteogeny to form, epiphysis distortion in late period, the articular surface out-of-flatness, the edge hyperosteogeny is obvious, under cartilage, there are sclerosis and blister cavities to form, the fuzzy or disappearance of fat pad under kneecap during the dish synovitis.
Drug therapy is mainly and controls symptom, improves the state of an illness, cartilage protection and local medicine for external use etc. at present, take pain relieving and improve motor function as main, take NSAID (non-steroidal anti-inflammatory drug) clinically as main in the past, glucosamine hydrochloride application in recent years is more, but these medicine amelioration of inflammation also ease the pain, but the pathological change that can not change osteoarthritis is basic, can only treat its disease, refractory its because of; Use anesthetis partial closure, pain can disappear in a short time, but easily outbreak repeatedly, prolonged application antipyretic-antalgic and hormone medicine, large and side effect is many to actual bodily harm, gastrointestinal side effect is obvious.
The many inflammation of knee joint all belong to the traditional Chinese medical science " knee muscle and tendon injury " category, Chinese medicine thinks that the gonarthritis cause of disease is due to body deficiency of both the liver and kidney, long-term strain, affection of exogenous wind-cold heresy, kidney governing bones, liver governing tendons, caused by liver and kidney deficiency can not nourishing bone, and strain and wound can form primary disease for a long time; Caused by liver and kidney deficiency, foster, the long-term strain of muscles and bones mistake, qi depression to blood stasis, wind-cold damp pathogen numbness resistance meridians are that the pathogenesis of this illness is basic." Plain Questions. five victory generate a piece of writing " say: " foot is subject to the walking of blood energy, and the palm can be held by blood, refers to be subject to blood to take the photograph." liver governing tendons, the spleen governing muscles extremity, it is closely related with liver spleen, QI and blood, Rong Wei that function of joint maintains." limbs damage in outside, QI and blood is hindered in interior, Rong Wei does not pass through to some extent " the synovial membrane damage, water seepage liquid, damp is detained.So the generation gonarthritis, the gonitis that synovitis etc. are common.The Chinese traditional treatment method comprises treatment by oral administration of medicines and external treatment etc., according to the principle of differentiation of tcm, mainly with liver and kidney tonifying, bone and muscle strengthening, is the rule for the treatment of greatly.
Chinese invention patent application CN201310143975.5 discloses " for the bones of the dead leaf powder of Knee Arthritis ", and it is comprised of Chinese crude drug Parathelypteris glanduligera (Kunze) Ching, Radix Heraclei Rapulae, Rhizoma Drynariae, Herba speranskiae tuberculatae, Folium Eucommiae, Sanguis Draxonis, Herba Asari, Pheretima, Herba Taxilli, Retinervus Luffae Fructus, Cortex Cinnamomi, Radix Angelicae Pubescentis, Squama Manis, the Radix Aucklandiae, Indigo Naturalis, Radix Glycyrrhizae.Chinese invention patent application CN201010162143.4 discloses " a kind of Chinese medicine composition for the treatment of gonitis and preparation method thereof ", it is combined by oral and medicine for external use, wherein oral Chinese medicine material Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Gentianae Macrophyllae, Radix Notoginseng, Radix Cynanchi Paniculati, Flos Carthami, Radix Achyranthis Bidentatae, Ramulus Cinnamomi, Caulis Spatholobi, Fructus Foeniculi, Rhizoma Polygoni Cuspidati, Zaocys, Radix Saposhnikoviae, Shen muscle grass, Rhizoma Drynariae, the Lao Huan grass of Cortex Eucommiae,, the Radix Paeoniae Alba; The external application Chinese medicine material comprises that Myrrha, Olibanum, Radix Dipsaci, Rhizoma Et Radix Notopterygii, Flos Carthami, Radix Notoginseng, Rhizoma Gastrodiae, Fructus Foeniculi, Radix Aconiti Preparata, Scorpio, Herba speranskiae tuberculatae form.Foregoing invention is rule for the treatment of prescription mainly with the invigorating kidney, promoting blood circulation pain-alleviating and network vessel-freeing greatly.
The present invention is the Chinese medicine composition with the effect of heat clearing away dredging collateral that screening obtains from Chinese crude drug, from the heat clearing away dredging collateral, is rule for the treatment of legislation prescription, thereby reaches the effect for the treatment of patient gonarthritis symptom.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, under Chinese medical theory instructs, by the rational proportion of each medical material, synergism, play the effect for the treatment of gonarthritis; Another one purpose of the present invention is to provide the preparation method of this Chinese medicine composition.
The Chinese medicine composition for the treatment of of the present invention, selecting Caulis Lonicerae, Lignum Sappan, Radix seu Caulis Jasmini lanceolarii, Rhizoma Bolbostematis, mountain Corallium Japonicum Kishinouye, Herba Begoniae Yunnanensis, Herba Pileae Plataniflorae, Folium Malvae is raw material, wherein Caulis Lonicerae heat clearing away dredging collateral, Radix seu Caulis Jasmini lanceolarii expelling wind and removing dampness promoting blood circulation and stopping pain, Rhizoma Bolbostematis mass dissipating and swelling eliminating, the pain relieving of Lignum Sappan removing blood stasis to reduce swelling, mountain Corallium Japonicum Kishinouye heat clearing away activating collaterals to relieve pain, the pain relieving of Herba Begoniae Yunnanensis blood-activating and qi-promoting, Herba Pileae Plataniflorae promoting blood circulation, dredging meridian and relieving pain, Folium Malvae heat clearing away removing obstruction in the collateral to relieve pain, each Chinese crude drug combination and compatibility, play heat clearing and blood circulation promoting pain relieving effect altogether.
The raw material consumption of preparation medicine activity component of the present invention is: Caulis Lonicerae 10-30 part, Lignum Sappan 10-20 part, Radix seu Caulis Jasmini lanceolarii 10-20 part, Rhizoma Bolbostematis 10-30 part, mountain Corallium Japonicum Kishinouye 5-25 part, Herba Begoniae Yunnanensis 10-20 part, Herba Pileae Plataniflorae 10-30 part, Folium Malvae 5-20 part; Be preferably 18 parts of Caulis Loniceraes, 12 parts of Lignum Sappans, 18 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Rhizoma Bolbostematiss, 9 parts, mountain Corallium Japonicum Kishinouye, 12 parts of Herba Begoniae Yunnanensis, 18 parts of Herba Pileae Plataniflorae, 12 parts of Folium Malvaes.
Chinese medicine composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into oral tablet, capsule, granule.
Below in conjunction with embodiment, the invention will be further elaborated
Embodiment 1 tablet preparation of the present invention
Take each crude drug by following weight proportion: Caulis Lonicerae 180 grams, Lignum Sappan 120 grams, Radix seu Caulis Jasmini lanceolarii 180 grams, Rhizoma Bolbostematis 120 grams, mountain Corallium Japonicum Kishinouye 90 grams, Herba Begoniae Yunnanensis 120 grams, Herba Pileae Plataniflorae 180 grams, Folium Malvae 120 grams are standby; The Chinese crude drug of above-mentioned weight mixes, and adds 6 times of water gagings and soaks 2 hours, and heating decocts 1.5 hours, filters, and medicinal residues add 5 times of water gaging heating again and decoct 1 hour, filter, and merge filtrate twice, standing 1 hour, pour out supernatant; Relative density 1.10 clear paste during supernatant concentration to 60 ℃, 60 ℃ of vacuum dryings, obtain solid content 100 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional tablet adjuvant granulation, drying, tabletting.
Embodiment 2 granule preparation of the present invention
Take each crude drug by following weight proportion: Caulis Lonicerae 100 grams, Lignum Sappan 100 grams, Radix seu Caulis Jasmini lanceolarii 100 grams, Rhizoma Bolbostematis 300 grams, mountain Corallium Japonicum Kishinouye 250 grams, Herba Begoniae Yunnanensis 200 grams, Herba Pileae Plataniflorae 300 grams, Folium Malvae 200 grams are standby; The medical material of above-mentioned weight mixes, and adds 5 times of water gagings and soaks 1.5 hours, and heating decocts 1 hour, filters, and medicinal residues add 4 times of water gaging heating again and decoct 1 hour, filter, and merge filtrate twice, standing 1 hour, pour out supernatant; Relative density 1.08 clear paste during supernatant concentration to 60 ℃, 60 ℃ of vacuum dryings, obtain solid content 150 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional granulates agent adjuvant, the granulation agent.
Embodiment 3 capsule preparation of the present invention
Take each crude drug by following weight proportion: Caulis Lonicerae 300 grams, Lignum Sappan 200 grams, Radix seu Caulis Jasmini lanceolarii 200 sections, Rhizoma Bolbostematis 100 grams, mountain Corallium Japonicum Kishinouye 50 grams, Herba Begoniae Yunnanensis 100 grams, Herba Pileae Plataniflorae 100 grams, Folium Malvae 50 grams are standby; The medical material of above-mentioned weight mixes, and adds 5 times of water gagings and soaks 1.5 hours, and heating decocts 1 hour, filters, and medicinal residues add 3 times of water gaging heating again and decoct 1 hour, filter, and merge filtrate twice, standing 1 hour, pour out supernatant; Relative density 1.08 clear paste during supernatant concentration to 60 ℃, 60 ℃ of vacuum dryings, obtain solid content 100 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional adjuvant, in the gelatine capsule of packing into, make capsule.
Experimental example 1
1. data and method
1.1 selected and exclusion standard
Collect the gonarthritis patient, knee joint pain repeatedly over nearly one month, x-ray shows that the knee joint hyperosteogeny forms, morning, deadlock was within half an hour; Joint motion has friction sound; Age is more than or equal to 45 years old; Arthralgia and II～III level dysfunction; Suffer from knee joint Weight carrying position X-ray film I～III level; The selected nearly first quarter moon of patient is not used the other drug treatment.Get rid of blood, digestion, Liver and kidney, metabolism, endocrine and function of nervous system and the abnormal person of decision-making ability; II level and the above cardiac dysfunction of II level and serious whole body complication; Local skin breakage or skin patient; Weight carrying position X-ray film IV level and above person.
1.2 case grouping
Meet inclusion criteria patient 55 examples, by medical order, be divided at random treatment group (traditional Chinese medicine composition for treating of the present invention) 30 example and matched group 25 examples; In treatment group patient's 30 examples, male's 17 examples, female's 13 examples, average course of disease 47.2 ± 6.5 months; In matched group patient 25 examples, male's 15 examples, female's 10 examples, average course of disease 45.3 ± 5.8 months; Two groups of patients have comparability (P > 0.05) at sex, age, the course of disease and symptom evaluation (Lequesne combined index basic value) several respects comparison there was no significant difference.
1.3 Therapeutic Method
Matched group gives glucosamine hydrochloride 0.48g/ time, 3 times/days; Treatment group gives Chinese medicinal composition granules of the present invention, twice of every day.Two groups of patient's continuous orals administration 28 days, viewing duration must not be used other influences arthritic symptom medicine.
1.4 index of assessment of curative effect
The clinical efficacy standard adopts knee osteoarthritis Lequesne combined index to estimate: comprising: joint rest pain, kinesalgia, tenderness, morning are stiff, walking several respects.After patient treatment, 2,4 weeks evaluation above-mentioned symptom integrations, take each item rating sum as the Lequesne combined index; Index variation is less than 30% for invalid, and index variation is greater than 30% for improving; Total effective rate is: the patient improves number/patient's sum * 100%.
2. result
2.1 two groups of patient treatment total effective rates relatively
Treatment group patient is respectively 73.3% and 93.3% with the surrounding total effective rate in two weeks after treatment, and matched group is respectively 72% and 80%, points out thus the treatment group curative effect to determine; The results are shown in following table 1.
Table 1 liang group patient total effective rate is (%) relatively
2.2 two groups of patient Lequesne combined index Assessment of Changes
After two groups of patient treatments, clinical symptoms all has in various degree to be alleviated, and the Lequesne combined index is on a declining curve; Treat before two weeks, surrounding and treatment relatively, there is significant difference (P<0.05), point out thus the treatment group curative effect to determine; The results are shown in following table 2.
Table 2 liang group patient Lequesne index variation result
The ※ representative is relatively front with treatment, P<0.05; Compare P<0.05 between △ representative group.
Claims (4)
1. a Chinese medicine composition for the treatment of gonarthritis, the active component that it is characterized in that it is to be made by the crude drug of following weight portion: Caulis Lonicerae 10-30 part, Lignum Sappan 10-20 part, Radix seu Caulis Jasmini lanceolarii 10-20 part, Rhizoma Bolbostematis 10-30 part, mountain Corallium Japonicum Kishinouye 5-25 part, Herba Begoniae Yunnanensis 10-20 part, Herba Pileae Plataniflorae 10-30 part, Folium Malvae 5-20 part.
2. according to the Chinese medicine composition of claim 1, wherein the consumption of each crude drug is: 18 parts of Caulis Loniceraes, 12 parts of Lignum Sappans, 18 parts of Radix seu Caulis Jasmini lanceolariis, 12 parts of Rhizoma Bolbostematiss, 9 parts, mountain Corallium Japonicum Kishinouye, 12 parts of Herba Begoniae Yunnanensis, 18 parts of Herba Pileae Plataniflorae, 12 parts of Folium Malvaes.
3. according to the preparation method of claim 1 or 2 described Chinese medicine composition, comprise the steps:
1) take each crude drug Caulis Lonicerae, Lignum Sappan, Radix seu Caulis Jasmini lanceolarii, Rhizoma Bolbostematis, mountain Corallium Japonicum Kishinouye, Herba Begoniae Yunnanensis, Herba Pileae Plataniflorae, Folium Malvae standby;
2) Caulis Lonicerae, Lignum Sappan, Radix seu Caulis Jasmini lanceolarii, Rhizoma Bolbostematis, mountain Corallium Japonicum Kishinouye, Herba Begoniae Yunnanensis, Herba Pileae Plataniflorae, the Folium Malvae by above-mentioned weight proportion mixes, add 5-6 times of water gaging and soak 1-2 hour, heating decocts 1.5 hours, filter, medicinal residues add 3-5 times of water gaging heating again and decoct 1 hour, filter, and merge filtrate twice, standing 1 hour, pour out supernatant; Relative density 1.05-1.10 clear paste during supernatant concentration to 60 ℃, 60 ℃ of vacuum dryings; Pulverize dry solid content, obtain fine powder, the i.e. active component of this Chinese medicine composition after sieving.
4. preparation method according to claim 3, by step 2) active component commonly use adjuvant with pharmaceutical preparation and mix, be prepared into tablet, capsule, granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720898A (en) * | 2014-01-23 | 2014-04-16 | 王爱梅 | Medicament for treating knee osteoarthritis |
| CN107913179A (en) * | 2016-10-10 | 2018-04-17 | 何竞钟 | A kind of far infrared moxibustion device |
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| WO2003059370A1 (en) * | 2002-01-18 | 2003-07-24 | Pangenomics Co., Ltd. | Crude drug compositions for treating or preventing arthritic diseases and the preparation process |
| CN101658582A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Chinese medicinal powder having effect of dissolving stasis and relieving pain |
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2013
- 2013-10-08 CN CN201310469989.6A patent/CN103494887A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003059370A1 (en) * | 2002-01-18 | 2003-07-24 | Pangenomics Co., Ltd. | Crude drug compositions for treating or preventing arthritic diseases and the preparation process |
| CN101658582A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Chinese medicinal powder having effect of dissolving stasis and relieving pain |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720898A (en) * | 2014-01-23 | 2014-04-16 | 王爱梅 | Medicament for treating knee osteoarthritis |
| CN107913179A (en) * | 2016-10-10 | 2018-04-17 | 何竞钟 | A kind of far infrared moxibustion device |
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Application publication date: 20140108 |