CN103463609B - The preparation method of the Chinese herbal oral decoction Chinese patent drug of the treatment infection of the upper respiratory tract - Google Patents
The preparation method of the Chinese herbal oral decoction Chinese patent drug of the treatment infection of the upper respiratory tract Download PDFInfo
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Abstract
Disclosed in this invention is a kind of preparation method of Chinese herbal oral decoction Chinese patent drug for the treatment of the infection of the upper respiratory tract. the Chinese medicine material component of described oral decoction: cassia twig, Chinese herbaceous peony, ginger, date, raw Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, loguat leaf, the moxibustion root bark of white mulberry, the moxibustion tuber of stemona, honeysuckle, reed rhizome, radix bupleuri, Huang Cen, the Radix Astragali, windproof, gypsum, the tuber of dwarf lilyturf, mother chrysanthemum, purple perilla, folium isatidis, ching-chieh, peppermint, dandelion, cordate houttuynia, Herba Andrographitis, Chinese violet, oldenlandia diffusa, notopterygium root, rattletop, the flower bud of lily magnolia, the root of Dahurain angelica, blackberry lily, great burdock achene, stickyhair pearleverlasting herb, balloonflower root, Radix Isatidis, the capsule of weeping forsythia, root of Chinese trichosanthes, myrobalan, moxibustion Chinese ephedra, subprostrate sophora, moxibustion tussilago, and decocting boils and forms Chinese herbal oral decoction, and described Chinese patent drug preparation method's step is, weigh, fry medicine, moxibustion medicine, extracts yellow Cen glycosides, collects distillate, the remaining medicine of poach, ethanol is concentrated, adds water filtration, filtrate packing. there is formula rationally, preparation method's science, the feature such as evident in efficacy.
Description
Technical field
The preparation method who the present invention relates to a kind of Chinese herbal oral decoction Chinese patent drug for the treatment of the infection of the upper respiratory tract, belongs to Chinese medicineField.
Background technology
The infection of the upper respiratory tract, refers to and occurs in from nasal cavity to the acute inflammation between throat, the clinically infection of the upper respiratory tractModal have common cold (acute rhinitis), acute and chronic tonsillitis, an acute and chronic pharyngitis etc.
In recent years, the method for the Chinese medicine infection of the upper respiratory tract, constantly weeded out the old and bring forth the new, and its drug formulation has decoction,Capsule, pill, spray, burns and sucks agent and nasal drop etc. What described formulation had an independent use clinically also has an associating use,Its curative effect is roughly close, efficient all between 80 ~ 90%.
And Chinese patent CN201110291232.3, though obtain clinically good curative effect, its Chinese drug-treated group usedPoint single, therapeutic alliance effect is not strong, concocts gimmick general, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition traditional Chinese medicine theory is indefinite, uses treatment for diseases modelEnclose extensivelyless, curative effect is very indefinite yet.
Because the infection of the upper respiratory tract is modal infectious diseases, if but it is treated not in time or is treated notAppropriate, usually can be because of concurrent various diseases, and seriously jeopardize patient's life. For this reason, adopt traditional Chinese medicine diagnosis and treatment based on an overall analysis of the illness and the patient's condition and multi-flavorThe medical procedure of Chinese medicine associating adapted, the experience of Bo Ji China traditional treatment, assembles the elite of multiple folk prescriptions, controls and propose oneThe Chinese herbal oral medicine for the treatment of the infection of the upper respiratory tract, with the masses that bring benefit to the people, just becomes traditional Chinese medical science research and development problem in the industry.
Summary of the invention
The present invention aims to provide a kind of diagnosis and treatment based on an overall analysis of the illness and the patient's condition, and kinds of traditional Chinese medicines associating adapted reaches science synergy, reach one completeWhole therapy system, result for the treatment of is treated the Chinese herbal oral decoction of the infection of the upper respiratory tract preferably, to benefit the numerous common people.
Known tcm theory is stated:
Loguat leaf: hardship, is slightly cold. Return lung channel, stomach warp. Removing heat from the lung to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Date: sweet, temperature. Return spleen, stomach warp. Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.
The moxibustion root bark of white mulberry: sweet, cold. Enter lung channel. Removing heat from lung and relieving asthma, inducing diuresis for removing edema.
Honeysuckle: pungent, cold. Return lung, stomach, the heart, large intestine channel. Clearing heat and detoxicating, expelling wind to resolve the exterior, dredge throat, the relieving restlessness of relieving summer heat.
Reed rhizome: sweet, cold. Attach to the lung and stomach meridians. Clearing heat-fire, promotes the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis.
Chinese herbaceous peony: bitter, property is flat, nontoxic. Antispastic, analgesia, emmenagogue.
Radix bupleuri: cold nature, bitter, pungent. Return Liver Channel, gallbladder channel. Table expels the heat-evil thoroughly, soothing liver-qi stagnation, lifting yang-energy.
The Radix Astragali: sweet, tepor. Return lung, spleen, liver, kidney channel. Invigorating qi for consolidating superficies, arrest sweating take off, hold in the palm sore myogenic, inducing diuresis for removing edema admittedly.
Huang Cen: hardship, cold. Return lung, courage, spleen, large intestine, small intestinl channel. Heat-clearing and damp-drying drug, purging intense heat and detonicating, arresting bleeding and miscarriage prevention, hypotensive.
Peppermint: pungent, cool. Enter lung channel, Liver Channel. Dispelling wind and heat from the body, the clear sharp head, relieve sore throat promoting eruption, soothing the liver promoting the circulation of qi.
Gypsum: pungent, sweet, be slightly cold. Attach to the lung and stomach meridians. Clearing heat-fire, relieving restlessness is quenched the thirst, convergence myogenic.
The tuber of dwarf lilyturf: sweet, micro-hardship, is slightly cold. The thoughts of returning home, lung, stomach warp. Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.
Mother chrysanthemum: bitter, pungent, cool in nature. Return lung, Liver Channel. Delicate fragrance is let out loose, clearing heat and detoxicating, the cool liver of dispelling wind.
The moxibustion tuber of stemona: hardship, sweet, tepor. Return lung channel. Moisten the lung and relieve the cough, delousing desinsection.
Folium isatidis: hardship, cold. Enter liver, the heart, stomach warp. Heat-clearing, removing toxic substances, cool blood, hemostasis.
Ching-chieh: taste is pungent, temperature, hardship, property is micro-wet. Enter lung, Liver Channel. Light a surname rises loose, expels pathogenic wind from the body surface, and declares malicious promoting eruption, and hemostasis onlyConvulsion.
Ginger: taste is pungent, tepor. Attach to the lung and stomach meridians. Inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, warm lung cough-relieving, solving toxin of fish and crab, antidote poison.
Dandelion: sweet, micro-hardship, cold. Clearing heat and detoxicating, dispersing swelling and dissipating binds.
Cordate houttuynia: cold nature, bitter. Return lung channel, bladder, large intestine channel. Clearing heat and detoxicating, removing pus and relieving carbuncle, inducing diuresis for treating strangurtia.
Herba Andrographitis: bitter, cold in nature. The thoughts of returning home, lung, large intestine, urinary bladder channel. Clearing heat and detoxicating, cool blood detumescence, eliminating dampness.
Chinese violet: hardship, pungent, cold, nontoxic. The thoughts of returning home, Liver Channel. Clearing heat and detoxicating, cool blood detumescence.
Oldenlandia diffusa: micro-hardship, micro-sweet, is slightly cold. The thoughts of returning home, liver, the spleen channel. Clearing heat and detoxicating, the carbuncle that disappears dissipating bind, inducing diuresis for removing edema.
Notopterygium root: taste is pungent, hardship, warm in nature. Enter bladder, kidney channel. Induce sweat loose cold, expelling wind and eliminating dampness, pain relieving.
Rattletop: pungent, micro-sweet, be slightly cold. Return lung, spleen, stomach, large intestine channel. Deliver promoting eruption, clearing heat and detoxicating, elevate a turnable ladder yang-energy.
The flower bud of lily magnolia: warm in nature, taste is pungent, micro-hardship. Attach to the lung and stomach meridians. Dispersing wind and cold, clearing the nasal passage.
The root of Dahurain angelica: pungent, temperature. Enter lung, spleen, stomach warp. Induce sweat loose cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness is band only, detumescence and apocenosis.
Windproof: taste is pungent, sweet, slightly warm in nature. Return bladder, liver, the spleen channel. Expel pathogenic wind from the body surface, removing dampness to relieve pain, only convulsion is jerked surely.
Cassia twig: acrid, sweet, warm. The thoughts of returning home, lung, urinary bladder channel. Sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain.
Blackberry lily: hardship, cold. Enter lung, Liver Channel. Clearing heat and detoxicating, throat, dissolving phlegm saliva.
Great burdock achene: taste is pungent, hardship, cold in nature. Attach to the lung and stomach meridians. Control anemopyretic cold, warm disease is from the beginning of, cough due to wind-heat evil, abscess of throat,Relax bowel.
Stickyhair pearleverlasting herb: pungent, temperature. Anti-inflammatory analgetic, stomach invigorating promoting the circulation of qi.
Balloonflower root: bitter, pungent, slightly warm in nature. Enter lung channel. Expelling phlegm and arresting coughing, the apocenosis of a surname's lung.
Purple perilla: pungent, temperature. Return lung channel. Sending down abnormally ascending dissolving phlegm, the ease constipation of relievining asthma.
Subprostrate sophora: hardship, cold, poisonous. Relieve inflammation or internal heat, removing toxic substances, detumescence, pain relieving.
Radix Isatidis: hardship, cold. Return liver, stomach warp. Clearing heat and detoxicating, cool blood relieve sore throat.
The capsule of weeping forsythia: hardship, is slightly cold. Enter the heart, lung, small intestinl channel. Clearing heat and detoxicating, dispersing swelling and dissipating binds, dispelling wind and heat from the body, have " persons particularly liable to develop skin infection's panacea " itClaim.
Root of Chinese trichosanthes: clearing heat and promoting fluid, detumescence and apocenosis.
Myrobalan: the puckery intestines of astringing the lung, lower gas relieve sore throat, controls for a long time and rushes down, protracted dysentery, prolapse of the anus, the phlegm of breathing with cough is coughed, chronic cough aphonia.
Moxibustion Chinese ephedra: pungent, micro-hardship, temperature. Return lung, urinary bladder channel. Heating is induced sweat, antiasthmatic-antitussive, inducing diuresis for removing edema.
Raw Radix Glycyrrhizae: sweet, be slightly cold. The thoughts of returning home, lung, spleen, stomach warp. Bushing temper, expelling phlegm and arresting coughing, relieving spasm to stop pain, relieving heat toxin and medicineFood poison, the mediation property of medicine.
Bulbus Fritillariae Cirrhosae: sweet, hardship, is slightly cold. Return lung, the heart channel of Hang-Shaoyin. Clearing heat and eliminating phlegm, moistens the lung and relieve the cough, mass dissipating and swelling eliminating.
Moxibustion tussilago: pungent, temperature. Return lung channel. Moistening lung to lower qi, preventing phlegm from forming and stopping coughing.
The present invention is based on described in above-mentioned tcm theory, taking the Guizhi decoction in " Treatise on Febrile and Miscellaneous Disease " of Zhang Zhongjing as basis, richAdopt the case of local tcm family, the elite of enrichment folk prescription, proved recipe, goes through clinical practice for many years, proposition realize its firstThe technical scheme of individual object is:
Treat a Chinese herbal oral decoction for the infection of the upper respiratory tract, and its:
A, the Chinese medicine material component of this Chinese herbal oral decoction and the weight of each component are: cassia twig 9g, Chinese herbaceous peony 9g, ginger 9g,Date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, loguat leaf 5 ~ 10g, the moxibustion root bark of white mulberry 5 ~ 15g, the moxibustion tuber of stemona 3 ~ 9g, gold and silverSpend 10 ~ 30g, reed rhizome 5 ~ 30g, radix bupleuri 3 ~ 10g, Huang Cen 5 ~ 15g, the Radix Astragali 10 ~ 15g, windproof 5 ~ 10g, gypsum 15 ~ 30g, the tuber of dwarf lilyturf10 ~ 20g, mother chrysanthemum 10 ~ 15g, purple perilla 3 ~ 9g, folium isatidis 15 ~ 25g, ching-chieh 3 ~ 9g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, fishRaw meat grass 15 ~ 25g, Herba Andrographitis 9 ~ 15g, Chinese violet 9 ~ 15g, oldenlandia diffusa 15 ~ 30g, notopterygium root 3 ~ 10g, rattletop 3 ~ 9g, the flower bud of lily magnolia3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, stickyhair pearleverlasting herb 9 ~ 12g, balloonflower root 10 ~ 20g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, myrobalan 3 ~ 6g, moxibustion Chinese ephedra 3 ~ 9g, subprostrate sophora 3 ~ 9g, moxibustion tussilago 10 ~ 20g;
B, decocts described Chinese medicine material component water the Chinese herbal oral decoction that forms the treatment infection of the upper respiratory tract.
Can be understood by above given purport technical scheme of the present invention, in " Treatise on Febrile and Miscellaneous Disease " of described Zhang ZhongjingGuizhi decoction is made up of traditional Chinese medicine of the five flavours, that is: cassia twig, Chinese herbaceous peony, Radix Glycyrrhizae, ginger, date. With cassia twig be monarch drug in a prescription, expelling pathogenic factors from muscles and skin is delivered, loose diseases caused by external factorsChill, is ministerial drug with Chinese herbaceous peony again, and beneficial the moon is held back battalion. " Guizhi decoction " uses the Rong Wei of Chinese herbaceous peony and flesh table; Osmanthus, Chinese herbaceous peony are harmonious, one control defend strong, oneA little less than controlling battalion, closing harmonizing yingfen and weifen, is that mutual reinforcement between is use. The pungent temperature of ginger, had both helped cassia twig expelling pathogenic factors from muscles and skin, can warm up again stomach preventing or arresting vomiting. Date is sweet flat, bothThe beneficial gas bowl spares of energy, can grow again spleen and promote the production of body fluid. Ginger, jujube are harmonious, and gas that can also the hair tonic of ascension taste and harmonizing yingfen and weifen, so and be assistantMedicine. The use of raw Radix Glycyrrhizae has two: one for adjutant, beneficial gas and in, close cassia twig with expelling pathogenic factors from muscles and skin, close Chinese herbaceous peony cloudy with benefit; One for making medicine, is in harmonious proportion allMedicine. Though described Guizhi decoction only has five kinds of Chinese medicine, compatibility is rigorous, in faling apart, has benefit, and in " the attached wing of the Treatise on Fevrile Diseases ", praising Guizhi decoction " is Zhong JingqunThe chief of side, is nourishing YIN for harmonizing YANG, harmonizing yingfen and weifen, and total side of expelling pathogenic factors from muscles by diaphoresis is also. "
On the basis of Guizhi decoction, the present invention, according to the illness of the infection of the upper respiratory tract, adds the relevant Chinese medicine of multi-flavor dialectically,Reach diagnosis and treatment based on an overall analysis of the illness and the patient's condition, the treatment of suiting the remedy to the case. Such as: aversion to wind and cold is person more very, should add windproof, ching-chieh expelling wind and cold pathogens; Physique elementVoid person, can add Radix Astragali benefit gas, with strengthening vital QI to eliminate pathogenic factors; Double see cough the person of breathing heavily, should add purple perilla, balloonflower root, a surname lung relieving cough and asthma; Table is real losslessPerson, with the mutual reinforcements between such as Chinese ephedra be use, to strengthen the merit of inducing sweat and dispelling exogenous evils; Exterior Qi instability, catches cold and sweating, joins windproof controlling with the Radix AstragaliIt; Ching-chieh is joined windproof, notopterygium root, controls chill table disease; Join honeysuckle, the capsule of weeping forsythia, peppermint, control wind-heat table disease; Join gypsum, control wind-heatHeadache; Join great burdock achene, balloonflower root, raw Radix Glycyrrhizae, control abscess of throat; Ginger coordinates Chinese ephedra, cassia twig to be equal to use, auxiliary as inducing sweat and dispelling exogenous evilsMedicine, to strengthen sweating strength; Belong to diseases caused by external factors card person, with disliking heat, dislike violent in numb osmanthus; While disliking cold with Lonicera and Forsythia, with ching-chieh, be windprooflySuitable; Motherland's medical science have saying of " all diseases of throat all belong to fire ", thinks its cause of disease, the heresy when interpretation of the cause, onset and process of an illness is mainly affection of exogenous wind-heat, evil poisonDirectly attack throat, the outer evil knot mutually of interior heat, above attacks throat, causes pharyngitis, and pain, suppurates, and doublely sees fever and headache, dysphagia,Cough trachyphonia, all diseases of losing the appetite. Subprostrate sophora in this prescription, Radix Isatidis nature and flavor bitter cold, both can be clearing heat and detoxicating, detumescence profitPharynx, cool blood, is aided with the capsule of weeping forsythia and can strengthens clearing heat and detoxicating merit, and the capsule of weeping forsythia can be shown by dispelling wind thoroughly, draws heresy and goes out, and balloonflower root can be ventilatingd the lung and resolving phlegm, and drawsMedicine is up, and assistant, with root of Chinese trichosanthes, can be promoted the production of body fluid and moisturize, and myrobalan's lower gas of can astringing the lung, controls aphonia. Wherein, subprostrate sophora is for controlling pharynx key medicine, Fang ZhongFor monarch drug in a prescription, but simultaneously with serious toxic and side effect, with raw Radix Glycyrrhizae, Chinese violet, the ministerial drugs such as oldenlandia diffusa are separated. Pale reddish brown groundFourth compatibility dandelion, mother chrysanthemum, Herba Andrographitis, oldenlandia diffusa, effect of its clearing heat, releasing toxin, removing swelling greatly increases. Join by these5 concoct gimmick, and the contained toxicity of part Chinese medicine greatly reduces, and both by outer heresy, the fire of deficiency type, falls in Ping Neire again, effectively red for throat,Swollen, heat, all diseases of pain.
And the various bulk drugs that adopt are the autonomic drug that the property of medicine is relatively gentle substantially, safe and reliable, and concoct letterJust, medicine source is wide, and cost is low, good effect. Through clinical verification, it is efficient reaches 95%, thereby has realized object of the present invention.
According to holding infection of the upper respiratory tract diagnosis and treatment based on an overall analysis of the illness and the patient's condition theory, distinguishing the prerequisite of cold and heat and asthenia and sthenia of the infection of the upper respiratory tractUnder, plus-minus compatibility of drugs and dosage ratio, under the commander of its purport technical scheme, below the present invention has further provided respectivelyChill, the wind-heat prescription of four kinds of infection of the upper respiratory tract flu, infection of the upper respiratory tract acute and chronic tonsillitis's prescription, and acute and chronic pharynxLaryngitis prescription. Specifically:
The Chinese medicine material component of a kind of Chinese herbal oral decoction that is used for the treatment of wind-chill cold of the first and the weight of each componentAmount is: cassia twig 9g, Chinese herbaceous peony 9g, ginger 9g, date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, the moxibustion tuber of stemona 3 ~ 9g, the Radix Astragali 10 ~ 15g, windproof 5 ~10g, ching-chieh 3 ~ 9g, notopterygium root 3 ~ 10g, the flower bud of lily magnolia 3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, balloonflower root 10 ~ 20g, purple perilla 3 ~ 9g, stickyhair pearleverlasting herb 9 ~ 12g,Radix Isatidis 15 ~ 30g, moxibustion Chinese ephedra 3 ~ 9g, moxibustion tussilago 10 ~ 20g.
It two is that a kind of Chinese medicine material component of Chinese herbal oral decoction for the treatment of anemopyretic cold and the weight of each component are,Date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, loguat leaf 5 ~ 10g, the moxibustion root bark of white mulberry 5 ~ 15g, honeysuckle 10 ~ 30g, reedRoot 15 ~ 30g, radix bupleuri 3 ~ 10g, Huang Cen 5 ~ 15g, Chinese herbaceous peony 9g, gypsum 15 ~ 30g, the tuber of dwarf lilyturf 10 ~ 20g, mother chrysanthemum 10 ~ 15g, smaltLeaf 15 ~ 25g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, cordate houttuynia 15 ~ 25g, Herba Andrographitis 9 ~ 15g, oldenlandia diffusa 15 ~ 30g, rattletop3 ~ 9g, blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia 15 ~ 25g.
It three is a kind of acute and chronic tonsillitis's for the treatment of the Chinese medicine material component of Chinese herbal oral decoction and the weight of each componentAmount is, it is used for the treatment of acute and chronic tonsillitis's the Chinese medicine material component of Chinese herbal oral decoction and the weight of each component is: rawRadix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, honeysuckle 10 ~ 30g, Huang Cen 5 ~ 15g, folium isatidis 15 ~ 25g, dandelion 15 ~ 25g, fish raw meatGrass 15 ~ 25g, notopterygium root 3 ~ 10g, the root of Dahurain angelica 4 ~ 10g, stickyhair pearleverlasting herb 9 ~ 12g, the capsule of weeping forsythia 15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, moxibustion Chinese ephedra 3 ~ 9g.
It four is a kind of Chinese medicine material component of Chinese herbal oral decoction for the treatment of acute and chronic pharyngitis and the weight of each componentBe, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, reed rhizome 15 ~ 30g, Huang Cen 5 ~ 15g, the tuber of dwarf lilyturf 10 ~ 20g, mother chrysanthemum 10 ~ 15g, smaltLeaf 15 ~ 25g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, cordate houttuynia 15 ~ 25g, Herba Andrographitis 9 ~ 15g, Chinese violet 9 ~ 15g, long-noded pit viperTongue grass 15 ~ 30g, rattletop 3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, subprostrate sophora 3 ~ 9g, Radix Isatidis 15 ~ 30g, companyStick up 15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, myrobalan 3 ~ 6g, moxibustion Chinese ephedra 3 ~ 9g.
And in the time that the above 5 kinds of Chinese herbal oral decoction is bottled or packed Chinese patent drug, in order to improve user's mouthSense, can gladly accept most patients, and the present invention also exists, and adds pharmaceutically acceptable auxiliary material in its oral decoctionSucrose 3 ~ 6wt%. Certainly, this is not suitable for use for the blood sugar patient that exceeds standard.
For the described Chinese medicine liquor of sugaring, the present invention also advocates with faintly acid for well, described Chinese patent drug mouthTake the pH value of decoction in 5 ~ 7 scopes.
After technique scheme is implemented in full, the feature such as the present invention has formula rationally, and result for the treatment of is good, isApparent.
The technical scheme that the present invention realizes its second object is:
Prepare a method for described Chinese patent drug oral decoction, this preparation method's step is:
, according to component formulation weight with identical multiple amplify draw materials weigh for subsequent use;
, get clean purple perilla, fry to there being detonans; Get clean great burdock achene, smash, put in pot, with extremely micro-heaving of slow fire stir-fry, outsideBe micro-yellow fragrance slightly, take out, cool; Astragalus mongholicus tablet is fried to buff with bran, sift out dry in the air cool, for subsequent use;
, the sweet moxibustion root bark of white mulberry, the tuber of stemona, Chinese ephedra, tussilago;
Get as required dry yellow Cen, Ultramicro-powder is broken into 200 ~ 300 object powder, adds the ultrasonic extraction 1 of water of 2 ~ 3 times of volumes~ 3 times, extract is concentrated into 1/3 ~ 1/2 volume, with charcoal absorption decolouring, be then extracted with ethyl acetate, extraction obtainsWater chloroform extraction, the water that extraction obtains is used extracting n-butyl alcohol again, reclaims n-butanol part and volatilize to obtain yellow Cen glycosides, standbyWith;
Get as required sweet moxibustion Chinese ephedra, honeysuckle, mother chrysanthemum, Herba Andrographitis, Chinese violet, oldenlandia diffusa, dandelion, smaltLeaf, stickyhair pearleverlasting herb adds the water soaking 2 ~ 3 hours of 2 ~ 4 times of volumes, and heating and refluxing extraction is collected distillate and the dregs of a decoction for subsequent use;
Get as required without stepExtremelyThe each taste Chinese medicine of remainder of concocting, with the step of learning from else's experience as required、ConcoctEach taste Chinese medicine and step except sweet moxibustion Chinese ephedraIn the dregs of a decoction decocting that adds 2 ~ 3 times of volumes after merging boil 2 ~ 3 times, each 2~ 2.5 hours, will merge decoction liquor, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
Combining stepYellow Cen glycosides and stepConcentrate, add the ethanol of 1.5 ~ 2.0 times of volumes, precipitation 24 ~48 hours, get supernatant and wave most ethanol, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
By stepGained concentrate, after centrifugal treating, is got supernatant, adds stepIn distillate, then addEnter pharmaceutically acceptable auxiliary material sucrose 3 ~ 6wt%, adjust PH to 5 ~ 7, add water purification filter, filtered fluid is for subsequent use;
Filtrate packing, the sterilization treatment after filling and sealing, makes packed or bottled Chinese patent drug oral decoction.
In the above preparation method's stepIn the rotating speed of centrifugal treating within the scope of 2500 ~ 6000RPM, centrifugal placeThe reason time is 5 ~ 10min.
From above given preparation method, the step strategy that the present invention has is reasonable, and technological process is easily controlled, systemThe features such as product quality is good are very obvious.
Detailed description of the invention
By the description of specific embodiment, the invention will be further described below.
Embodiment 1
Treat a Chinese herbal oral decoction for the infection of the upper respiratory tract, its:
A, the Chinese medicine material combination of this Chinese herbal oral decoction and the weight of each component are: cassia twig 9g, Chinese herbaceous peony 9g, ginger 9g,Date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, loguat leaf 5 ~ 10g, the moxibustion root bark of white mulberry 5 ~ 15g, the moxibustion tuber of stemona 3 ~ 9g, gold and silverSpend 10 ~ 30g, reed rhizome 5 ~ 30g, radix bupleuri 3 ~ 10g, Huang Cen 5 ~ 15g, the Radix Astragali 10 ~ 15g, windproof 5 ~ 10g, gypsum 15 ~ 30g, the tuber of dwarf lilyturf10 ~ 20g, mother chrysanthemum 10 ~ 15g, purple perilla 3 ~ 9g, folium isatidis 15 ~ 25g, ching-chieh 3 ~ 9g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, fishRaw meat grass 15 ~ 25g, Herba Andrographitis 9 ~ 15g, Chinese violet 9 ~ 15g, oldenlandia diffusa 15 ~ 30g, notopterygium root 3 ~ 10g, rattletop 3 ~ 9g, the flower bud of lily magnolia3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, stickyhair pearleverlasting herb 9 ~ 12g, balloonflower root 10 ~ 20g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, myrobalan 3 ~ 6g, moxibustion Chinese ephedra 3 ~ 9g, subprostrate sophora 3 ~ 9g, moxibustion tussilago 10 ~ 20g;
B, decocts described Chinese medicine material component blending water the Chinese herbal oral decoction that forms the treatment infection of the upper respiratory tract.
That embodiment 1 is given is a kind of logical side who treats the infection of the upper respiratory tract, and it is monarch drug in a prescription of the present invention. At embodimentOn 1 basis, according to illness reaction, dialectically by the plus-minus to its Chinese medicine raw material components and the plus-minus of each composition weight, pointHuo get not treat the prescription of wind-chill cold, anemopyretic cold, acute and chronic tonsillitis and acute and chronic pharyngitis.
Embodiment 2
Treat a Chinese herbal oral decoction for wind-chill cold, the weight of its Chinese medicine raw material components and each component is, cassia twig9g, Chinese herbaceous peony 9g, ginger 9g, date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, the moxibustion tuber of stemona 3 ~ 9g, the Radix Astragali 10 ~ 15g, windproof 5 ~ 10g, schizonepetaFringe 3 ~ 9g, notopterygium root 3 ~ 10g, the flower bud of lily magnolia 3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, balloonflower root 10 ~ 20g, purple perilla 3 ~ 9g, stickyhair pearleverlasting herb 9 ~ 12g, Radix Isatidis 15 ~30g, moxibustion Chinese ephedra 3 ~ 9g, moxibustion tussilago 10 ~ 20g.
And described Chinese medicine material component water decocts and forms Chinese herbal oral decoction.
Embodiment 3
Treat a Chinese herbal oral decoction for anemopyretic cold, the weight of its Chinese medicine raw material components and each component is, date 6~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, loguat leaf 5 ~ 10g, the moxibustion root bark of white mulberry 5 ~ 15g, honeysuckle 10 ~ 30g, reed rhizome 15 ~30g, radix bupleuri 3 ~ 10g, Huang Cen 5 ~ 15g, Chinese herbaceous peony 9g, gypsum 15 ~ 30g, the tuber of dwarf lilyturf 10 ~ 20g, mother chrysanthemum 10 ~ 15g, folium isatidis 15 ~25g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, cordate houttuynia 15 ~ 25g, Herba Andrographitis 9 ~ 15g, oldenlandia diffusa 15 ~ 30g, rattletop 3 ~ 9g,Blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia 15 ~ 25g.
And described Chinese medicine material component water decocts and forms Chinese herbal oral decoction.
Embodiment 4
Treat acute and chronic tonsillitis's a Chinese herbal oral decoction, the weight of its Chinese medicine material combination and each combination is,Raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, honeysuckle 10 ~ 30g, Huang Cen 5 ~ 15g, folium isatidis 15 ~ 25g, dandelion 15 ~ 25g, fishRaw meat grass 15 ~ 25g, notopterygium root 3 ~ 10g, the root of Dahurain angelica 4 ~ 10g, stickyhair pearleverlasting herb 9 ~ 12g, the capsule of weeping forsythia 15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, moxibustion Chinese ephedra 3 ~ 9g.
And described Chinese medicine material component water decocts and forms Chinese herbal oral decoction.
Embodiment 5
Treat a Chinese herbal oral decoction for acute and chronic pharyngitis, the weight of its Chinese medicine raw material components and each component is,Raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~ 10g, reed rhizome 15 ~ 30g, Huang Cen 5 ~ 15g, the tuber of dwarf lilyturf 10 ~ 20g, mother chrysanthemum 10 ~ 15g, folium isatidis15 ~ 25g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, cordate houttuynia 15 ~ 25g, Herba Andrographitis 9 ~ 15g, Chinese violet 9 ~ 15g, oldenlandiaGrass 15 ~ 30g, rattletop 3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, blackberry lily 3 ~ 9g, great burdock achene 5 ~ 10g, subprostrate sophora 3 ~ 9g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, myrobalan 3 ~ 6g, moxibustion Chinese ephedra 3 ~ 9g.
And described Chinese medicine material component water decocts and forms Chinese herbal oral decoction.
In the above 5 embodiment, can be according to conditions of patients, to the weight of its Chinese medicine raw material components, givenWeight range in consider as a whole dialectically and add and subtract. And in the time that needs are made into Chinese medicine liquor, can add 3 ~ 6wt%Sucrose, and its pH value is in 5 ~ 7 scopes.
A method of preparing Chinese patent drug oral decoction as described in Example 1, this preparation method's step is:
, according to component formulation weight with identical multiple amplify draw materials weigh for subsequent use;
, get clean purple perilla, fry to there being detonans; Get clean great burdock achene, smash, put in pot, with extremely micro-heaving of slow fire stir-fry, outsideBe micro-yellow fragrance slightly, take out, cool; Astragalus mongholicus tablet is fried to buff with bran, sift out dry in the air cool, for subsequent use;
, the sweet moxibustion root bark of white mulberry, the tuber of stemona, Chinese ephedra, tussilago;
Get as required dry yellow Cen, Ultramicro-powder is broken into 200 ~ 300 object powder, adds the ultrasonic extraction 1 of water of 2 ~ 3 times of volumes~ 3 times, extract is concentrated into 1/3 ~ 1/2 volume, with charcoal absorption decolouring, be then extracted with ethyl acetate, extraction obtainsWater chloroform extraction, the water that extraction obtains is used extracting n-butyl alcohol again, reclaims n-butanol part and volatilize to obtain yellow Cen glycosides, standbyWith;
Get as required sweet moxibustion Chinese ephedra, honeysuckle, mother chrysanthemum, Herba Andrographitis, Chinese violet, oldenlandia diffusa, dandelion, smaltLeaf, stickyhair pearleverlasting herb adds the water soaking 2 ~ 3 hours of 2 ~ 4 times of volumes, and heating and refluxing extraction is collected distillate and the dregs of a decoction for subsequent use;
Get as required without stepExtremelyThe each taste Chinese medicine of remainder of concocting, with the step of learning from else's experience as required、ConcoctEach taste Chinese medicine and step except sweet moxibustion Chinese ephedraIn the dregs of a decoction decocting that adds 2 ~ 3 times of volumes after merging boil 2 ~ 3 times, each 2~ 2.5 hours, will merge decoction liquor, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
Combining stepYellow Cen glycosides and stepConcentrate, add the ethanol of 1.5 ~ 2.0 times of volumes, precipitation 24 ~48 hours, get supernatant and wave most ethanol, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
By stepGained concentrate, after centrifugal treating, is got supernatant, adds stepIn distillate, then addEnter pharmaceutically acceptable auxiliary material sucrose 3 ~ 6wt%, adjust PH to 5 ~ 7, add water purification filter, filtered fluid is for subsequent use;
Filtrate packing, the sterilization treatment after filling and sealing, makes packed or bottled Chinese patent drug oral decoction.
In above-mentioned preparation method, stepUltrasonic power be 250 ~ 800w, the ultrasonic processing time is 25 ~ 40min; AndStepCentrifugal rotational speed within the scope of 2500 ~ 6000RPM, the centrifugal treating time is 5 ~ 10min, and stepInstitute adds water purificationConsumption, according to actual measurement pH value (5 ~ 7) determine.
The concise and to the point description that adopts the present invention to treat infection of the upper respiratory tract situation is: the present invention is through zoopery and pharmacological evaluationAfter, year September in September, 2010 to 2011, be applied to the court's clinical treatment respiratory tract infection case 120 examples, wherein male 75 examples, female45 examples, 6 years old to 70 years old age; Outbreak 50 examples that the state of an illness is slight, moderate 45 examples of showing effect, severe attack 25 examples, patient makes a definite diagnosis on inspectionFor the infection of the upper respiratory tract. Adopt the present invention to treat person's 5 days (course for the treatment of), most of patient's symptom is clearly better, part severePatient took the present invention after 10 days, and symptom turns for the better by and large, and statistics shows, in 120 routine patients, through taking the present invention's treatmentAfter, wherein effective 65 examples, take a turn for the better 49 examples, invalid 6 examples, total effective rate is 95%, its efficient apparently higher than 80 of prior art ~90％。
Below exemplify two model cases, specifically describe curative effect of the present invention.
Case 1,, soup so-and-so, man, 12 years old, people from Wujin, Jiangsu.
Patient because of infection of the upper respiratory tract acute attack in October 20 in 2010 Lai the court Pediatric Clinic medical. Fear while being admitted to hospitalCold low-heat, thin nasal discharge, head-body-pain, trachyphonia cough. Check that visible tongue nature is light red, thin white fur of tongue, floating and tense pulse. Nasal membrane fillsBlood, oedema, has secretion, pharyngeal mild hyperaemia. Diagnosis wind-chill cold (acute rhinitis). Previously there is asthma medical history. Routine blood test:White blood cell count(WBC) is normal, and percentage of lymphocyte raises. Pulmonary function test shows: pulmonary ventilation function slightly go down (obstructive). WhenDay oral the present invention, advises its serve on 5 days (course for the treatment of), every day twice, sub-service morning and afternoon. To on the October 25th, 2010 of door againWhile examining, main stating without aversion to cold, heating, cough. Pink tongue, tongue is thin in vain, and pulse condition is gentle strong. Pulmonary function test shows: pulmonary ventilation meritCan normal. Follow up a case by regular visits to not recurrence so far.
Case 2: Zhang, man, 57 years old, people from Wujin, Jiangsu.
Patient because headache cough, trachyphonia have a stuffy noses, are had sore throat, fever with chilliness is in Lai the court breathing Augusts 15 in 2011Section is medical. Slightly out of breath, uncomfortable in chest while being admitted to hospital, the two lungs of auscultation are without obvious wheezing sound. Check visible tongue nature light fat or have become silted up resemble, tongue is whiteLubricious, pulse condition is taut pulse. Laryngeal edema, hyperemia, regional nodes's silght enlargement and tenderness, Ou Wen throat whoop. Diagnosis is anxiousPharyngitis. Previously there is a slow medical history. Routine blood test: white blood cell count(WBC) and neutrophilic leukocytosis and shift to left phenomenon, lymph is thinBorn of the same parents' ratio raises. Pulmonary function test shows: pulmonary ventilation function moderate go down (obstructive). Oral the present invention on the same day, advises it to serve on10 days (two courses for the treatment of), every twice-daily, sub-service morning and afternoon. When again medical on August 25th, 2011, main state no headache, nasal obstruction,Sneeze, runny nose, have sore throat. Pink tongue, tongue is thin in vain, and pulse condition relaxes. Pulmonary function test shows: pulmonary ventilation function slightly goes down(obstructive). Follow up a case by regular visits to not recurrence so far.
Claims (4)
1. treat a preparation method for the Chinese herbal oral decoction Chinese patent drug of the infection of the upper respiratory tract, the Chinese medicine of this Chinese herbal oral decoctionThe weight of material combination and each component is: cassia twig 9g, Chinese herbaceous peony 9g, ginger 9g, date 6 ~ 15g, raw Radix Glycyrrhizae 10 ~ 20g, Bulbus Fritillariae Cirrhosae 5 ~10g, loguat leaf 5 ~ 10g, the moxibustion root bark of white mulberry 5 ~ 15g, the moxibustion tuber of stemona 3 ~ 9g, honeysuckle 10 ~ 30g, reed rhizome 5 ~ 30g, radix bupleuri 3 ~ 10g, HuangCen 5 ~ 15g, the Radix Astragali 10 ~ 15g, windproof 5 ~ 10g, gypsum 15 ~ 30g, the tuber of dwarf lilyturf 10 ~ 20g, mother chrysanthemum 10 ~ 15g, purple perilla 3 ~ 9g, largeLeafiness 15 ~ 25g, ching-chieh 3 ~ 9g, peppermint 3 ~ 6g, dandelion 15 ~ 25g, cordate houttuynia 15 ~ 25g, Herba Andrographitis 9 ~ 15g, Chinese violet9 ~ 15g, oldenlandia diffusa 15 ~ 30g, notopterygium root 3 ~ 10g, rattletop 3 ~ 9g, the flower bud of lily magnolia 3 ~ 9g, the root of Dahurain angelica 4 ~ 10g, blackberry lily 3 ~ 9g, great burdock achene 5~ 10g, stickyhair pearleverlasting herb 9 ~ 12g, balloonflower root 10 ~ 20g, Radix Isatidis 15 ~ 30g, the capsule of weeping forsythia 15 ~ 25g, root of Chinese trichosanthes 9 ~ 15g, myrobalan 3 ~ 6g, moxibustion fiber cropsYellow 3 ~ 9g, subprostrate sophora 3 ~ 9g, moxibustion tussilago 10 ~ 20g;
Described Chinese medicine material component water is decocted to the Chinese herbal oral decoction that forms the treatment infection of the upper respiratory tract, it is characterized in that:
This preparation method's step is:
, according to component formulation weight with identical multiple amplify draw materials weigh for subsequent use;
, get clean purple perilla, fry to there being detonans; Get clean great burdock achene, smash, put in pot, fry to micro-heaving with slow fire, it is micro-that outside isYellow slightly fragrance, take out, and cools; Astragalus mongholicus tablet is fried to buff with bran, sift out dry in the air cool, for subsequent use;
, the sweet moxibustion root bark of white mulberry, the tuber of stemona, Chinese ephedra, tussilago;
, get dry yellow Cen as required, Ultramicro-powder is broken into 200 ~ 300 object powder, adds the ultrasonic extraction 1 ~ 3 of water of 2 ~ 3 times of volumesInferior, extract is concentrated into 1/3 ~ 1/2 volume, with charcoal absorption decolouring, be then extracted with ethyl acetate the water that extraction obtainsUse mutually chloroform extraction, the water that extraction obtains is used extracting n-butyl alcohol again, reclaims n-butanol part and volatilize to obtain yellow Cen glycosides, standbyWith;
, get sweet moxibustion Chinese ephedra as required, honeysuckle, mother chrysanthemum, Herba Andrographitis, Chinese violet, oldenlandia diffusa, dandelion, folium isatidis,Stickyhair pearleverlasting herb adds the water soaking 2 ~ 3 hours of 2 ~ 4 times of volumes, and heating and refluxing extraction is collected distillate and the dregs of a decoction for subsequent use;
, get without step as requiredExtremelyThe each taste Chinese medicine of remainder of concocting, with the step of learning from else's experience as required、Removing of concocting is sweetEach taste Chinese medicine and step outside moxibustion Chinese ephedraIn the dregs of a decoction decocting that adds 2 ~ 3 times of volumes after merging boil 2 ~ 3 times, each 2 ~ 2.5Hour, will merge decoction liquor, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
, combining stepYellow Cen glycosides and stepConcentrate, add the ethanol of 1.5 ~ 2.0 times of volumes, precipitation 24 ~ 48Hour, get supernatant and wave most ethanol, be concentrated into 1/2 ~ 2/3 volume, gained concentrate is for subsequent use;
, by stepGained concentrate, after centrifugal treating, is got supernatant, adds stepIn distillate, then add and be used as medicineAcceptable auxiliary material sucrose 3 ~ 6wt% on, adjusts pH to 5 ~ 7, adds water purification filter, and filtered fluid is for subsequent use;
, filtrate packing, through filling and sealing after sterilization treatment, make packed or bottled Chinese patent drug oral decoction.
2. the preparation method of Chinese herbal oral decoction Chinese patent drug according to claim 1, is characterized in that, its stepSuperAcoustical power is 250 ~ 800W, and the ultrasonic processing time is 25 ~ 40min.
3. the preparation method of Chinese herbal oral decoction Chinese patent drug according to claim 1, is characterized in that, its stepFromHeart rotating speed is within the scope of 2500 ~ 6000RPM, and the centrifugal treating time is 5 ~ 10min.
4. the preparation method of Chinese herbal oral decoction Chinese patent drug according to claim 1, is characterized in that, its stepInstitute addsThe consumption of water purification, determines according to the pH value of actual measurement.
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| CN103977277A (en) * | 2014-04-28 | 2014-08-13 | 秦文雄 | Traditional Chinese medicine preparation for preventing and treating upper respiratory tract infection and sore throat |
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| CN105267471A (en) * | 2014-07-19 | 2016-01-27 | 葛以东 | Formula for treatment of acute or chronic tonsillitis |
| CN104225370A (en) * | 2014-10-11 | 2014-12-24 | 侨健新能源科技（苏州）有限公司 | Traditional Chinese medicine for treating chronic laryngitis and enhancing immunity |
| CN104258189A (en) * | 2014-10-11 | 2015-01-07 | 侨健新能源科技（苏州）有限公司 | Traditional Chinese medicine preparation for treating chronic laryngitis |
| CN104288373A (en) * | 2014-10-27 | 2015-01-21 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine composition for treating upper respiratory tract infection |
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| CN105410287A (en) * | 2015-12-28 | 2016-03-23 | 黄衡宇 | Healthcare tea for treating cold |
| CN105396114A (en) * | 2015-12-28 | 2016-03-16 | 刘树芹 | Medicine composition for treating respiratory tract infection |
| CN105770658B (en) * | 2016-05-17 | 2020-02-14 | 上饶市莎江高科生物有限公司 | Chinese medicinal preparation for treating oral diseases |
| CN110742339A (en) * | 2019-10-30 | 2020-02-04 | 山东省中医药研究院 | Respiratory syncytial virus resistant mask and preparation method thereof |
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