CN111420010A - Medicine-separating moxibustion medicine for tonifying internal organs and preparation method thereof - Google Patents
Medicine-separating moxibustion medicine for tonifying internal organs and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicine-separating moxibustion medicine for tonifying viscera and a preparation method thereof, wherein the medicine-separating moxibustion medicine for tonifying viscera consists of 6g of astragalus mongholicus, 6g of codonopsis pilosula, 6g of poria, 6g of bighead atractylodes rhizome, 6g of angelica sinensis, 6g of ligusticum wallichii, 6g of prepared rehmannia rhizome, 6g of white paeony root, 6g of vinegar radix bupleuri, 3g of cinnamon, 3g of rhizoma curculiginis, 3g of epimedium, 3g of coptis chinensis, 3g of cape jasmine and 3g of radix curcumae. The invention purifies the traditional Chinese medicines respectively according to different characteristics of the traditional Chinese medicines, and mixes, stirs and dries the extracting solution to obtain the medicine, and when in use, the fresh ginger water, the medicine which is ground into powder and the paste form are externally applied. The invention has the functions of regulating qi and blood, nourishing viscera, regulating spleen and stomach, strengthening spirit, nourishing skin, relieving fatigue, tonifying deficiency and the like, has no side effect, and can thoroughly solve the problem of consumptive disease.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a drug-separating moxibustion medicine for tonifying internal organs and a preparation method thereof.
Background
Currently, the closest prior art: the existing mode for treating consumptive disease generally adopts the targeted therapeutic prescription for tonifying qi, nourishing blood, nourishing yin and warming yang to be taken orally, and obtains better curative effect on different recognitions and prescription principles of the disease. Moxibustion is an external treatment method, and is more easily accepted by many patients clinically due to the advantages of comfort, safety and no side effect. The moxibustion method can promote the better absorption of the medicine in the moxibustion application process by matching with the medicine-separated moxibustion medicine for tonifying the viscera, not only plays the role of moxibustion, but also can combine the efficacy of the traditional Chinese medicine, thereby greatly increasing the treatment effect. Consumptive disease, also called as deficiency, is caused by various reasons such as weak essence, malnutrition after birth, and exogenous internal injury, and is a general term for various chronic weakness syndromes with the decline of visceral functions, impairment of qi, blood, yin and yang, and chronic weakness syndromes as the main clinical manifestations.
The existing mode for treating consumptive disease generally adopts the treatment prescription drugs of pertinence tonifying qi, nourishing blood, nourishing yin and warming yang, but every person has different constitutions, and the internal organs of the human body are an organic whole, and the problem of consumptive disease cannot be completely solved by simply pertinence tonifying, and the consumptive disease is often accompanied with the recurrence condition.
In summary, the problems of the prior art are as follows:
(1) the existing medicines for tonifying the internal organs can only tonify specific symptoms such as hypofunction, and the problem of consumptive disease can not be completely solved after being taken.
(2) The existing diaphragm medicine moxibustion medicine for treating consumptive disease has not been reported yet. In addition, the effective components of the drugs cannot be fully absorbed in the moxibustion process, and all the drugs need to be purified by a technology to exert better treatment effect.
The significance of solving the technical problems is as follows: finds a comfortable, safe and effective method for treating consumptive disease without toxic and side effects, and improves the clinical curative effect.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a drug-separating moxibustion medicine for tonifying internal organs and a preparation method thereof.
The invention is realized in such a way, and the medicine-separating moxibustion medicine for tonifying viscera consists of 6g of astragalus, 6g of codonopsis pilosula, 6g of poria, 6g of bighead atractylodes rhizome, 6g of angelica, 6g of ligusticum wallichii, 6g of radix rehmanniae preparata, 6g of white paeony root, 6g of vinegar radix bupleuri, 3g of cinnamon, 3g of rhizoma curculiginis, 3g of epimedium herb, 3g of coptis chinensis, 3g of cape jasmine and 3g of radix curcumae.
Further, the preparation method of the drug-separated moxibustion medicine for tonifying the internal organs specifically comprises the following steps:
step one, distilling 6g of angelica and 6g of ligusticum wallichii by water vapor to collect volatile oil and distilled residual liquid, decocting the residues with water, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain a first stock solution for later use.
And step two, taking 6g of radix scutellariae and 6g of rhizoma atractylodis macrocephalae, heating and refluxing the radix scutellariae and the 6g of rhizoma atractylodis macrocephalae through 60-95 vol% ethanol, collecting an extracting solution, taking the medicine residues, adding water, decocting, filtering, collecting a filtrate, mixing the extracting solution and the filtrate, and concentrating to obtain a second stock solution for later use.
And step three, taking 6g of codonopsis pilosula, 6g of white paeony root and 6g of vinegar radix bupleuri, cutting up, adding 7-10 times of pure water, decocting for 2-3 times, 2-3 hours each time, filtering, collecting filtrate, concentrating the filtrate under reduced pressure to obtain a semi-fluid, standing and cooling to obtain a third stock solution for later use.
Step four, removing impurities from 6g of poria, drying, uniformly mixing, adding water for decoction, and filtering to obtain a first decoction and medicinal material residues; decocting the residue to obtain a second decoction; mixing the two decoctions, concentrating to obtain semi-fluid, standing, and cooling to obtain fourth stock solution.
And fifthly, taking 6g of prepared rehmannia root, frying for 13 minutes by using slow fire, crushing into powder of 200-300 meshes, adding 2-3 times of volume of water for ultrasonic extraction for 1-3 times, concentrating the extracting solution to 1/3-1/2 volume, adsorbing and decoloring by using activated carbon, extracting by using ethyl acetate, extracting the obtained water phase by using chloroform, extracting the obtained water phase by using n-butyl alcohol, concentrating the obtained extracting solution to a semi-fluid, standing and cooling to obtain a fifth stock solution for later use.
Step six, taking 3g of cinnamon, adding an aqueous solvent for soaking and extracting, and respectively collecting the cinnamon raw material and the soaking extract after soaking and extracting; adding ethanol into the soaked and extracted cinnamon raw material for reflux extraction, and respectively collecting the cinnamon raw material and the reflux extracting solution after reflux extraction; mixing the soaking extract and the refluxing extract, concentrating to obtain a semi-fluid, standing, and cooling to obtain a sixth stock solution for later use.
And step seven, crushing and sieving 3g of rhizoma curculiginis, mixing 1 part by weight of rhizoma curculiginis powder obtained by crushing with 0.5 part by weight of diatomite, adding the mixture into an extraction tank for static extraction, extracting by adopting a rapid solvent extraction method to obtain an extract, concentrating to a semi-fluid, standing and cooling to obtain a seventh stock solution for later use.
And step eight, extracting 3g of epimedium herb with water, precipitating with ethanol, concentrating the obtained supernatant under reduced pressure, concentrating to obtain a semi-fluid, standing and cooling to obtain an eighth stock solution for later use.
And step nine, crushing 3g of coptis chinensis, carrying out ultrasonic extraction for 30-45min, standing the extracting solution for 5-10h with 75-95% ethanol in an amount which is 10-15 times that of the extracting solution, filtering to obtain filtrate, concentrating the filtrate into a semi-fluid, and standing and cooling to obtain a ninth stock solution for later use.
Step ten, taking 3g of gardenia, placing the gardenia on a manual operation table, removing impurities, fruit stalks, branches and other non-medicinal parts, placing the gardenia in a microwave generator, taking out the gardenia and grinding the gardenia; adding 7-10 times of pure water, decocting for 2-3 times, each time for 2-3 hr, filtering, collecting filtrate, concentrating under reduced pressure to obtain semi-fluid, standing, and cooling to obtain tenth stock solution.
Step eleven, performing CO2 supercritical extraction on 3g of radix curcumae to obtain radix curcumae extract and radix curcumae extract residues, coating the extract with β -cyclodextrin to obtain an inclusion compound, performing alcohol extraction, filtering to obtain alcohol extraction residues and filtrate, concentrating the filtrate to obtain alcohol extraction extract, mixing and concentrating the alcohol extraction extract and the inclusion compound to obtain a semi-fluid, standing and cooling to obtain an eleventh stock solution for later use.
And step twelve, mixing the first stock solution and the eleventh stock solution, placing the mixture into a stirrer to be stirred for 20-25min, and placing the mixture into a drying device to be dried by using high-temperature flue gas after stirring.
Further, in the first step, steam distillation is performed for 1-2 times, each time lasts for 2-10 hours, and the first decoction is that the mass-to-volume ratio of the first decoction dregs to water is 1: 6-12 in g: m L.
Further, in the second step, ethanol is refluxed for 1-3 times, each time is 1-5 hours, and the second decoction is that the mass-to-volume ratio of the second decoction dregs to water is 1: 6-12 in g: m L.
Further, in the fourth step, the first decoction time is 5 hours, the temperature is 60-70 ℃, the water volume is 1.5 times of the volume for submerging all the medicinal materials, the second decoction time is 3 hours, the temperature is 60-70 ℃, and the water volume is based on submerging the medicinal materials.
Further, in the seventh step, the weight ratio of the extraction solvent is 2: 8, extracting at 100 ℃ by using a mixed solution of isopropanol and methanol; static extraction time is 5 min; the volume of the rinse is 100%; number of static cycles 1.
Further, in step ten, the optimum microwave drying power is 600w, heating for 40 s.
Further, in step eleven, CO2The supercritical extraction conditions were: the extraction pressure is 25-35MPa, the extraction temperature is 25-35 ℃, and CO is added2The flow rate is 11-15L/h, the extraction time is 1-2h, and the curcuma aromatica extract and the raffinate are obtained.
Further, in the eleventh step, the turmeric root tuber raffinate is added with 70% -90% ethanol with the weight 6-10 times of that of the turmeric root tuber medicinal material for reflux extraction for 1-3 times, each time is 1-2 hours, the reflux liquid is kept stand for more than 12 hours, and supernatant is absorbed.
Further, in the eleventh step, β -cyclodextrin is included under the conditions that the ratio of the extract to β -cyclodextrin is 1ml to 3-5g, the amount of water is 4-8 times, and the inclusion time is 20-60 minutes.
Further, in the eleventh step, β -cyclodextrin is included to obtain an inclusion compound, preferably under the inclusion condition that the weight ratio of the extract to β -cyclodextrin is 1ml:5g, 8 times of water of β -cyclodextrin is added for inclusion for 60 min.
Another object of the present invention is to provide a method for using a drug-separated moxibustion medicine for tonifying the zang-fu organs, comprising:
firstly, taking moxibustion medicine, mashing the moxibustion medicine in a mashing tank to obtain powder, and taking out the powder for later use.
Step two, shredding fresh ginger, putting into a pot, adding water for boiling, stopping heating after boiling for 10min, and taking out;
and step three, mixing the fresh ginger juice taken out and the mashed moxibustion medicine into paste by using a glass rod, and externally coating the paste.
In summary, the advantages and positive effects of the invention are: the invention adopts external application for treatment and adjustment, has various effects of harmonizing qi and blood, nourishing viscera, regulating spleen and stomach, strengthening spirit, nourishing skin, relieving fatigue, tonifying deficiency and the like, has no side effect, and can thoroughly solve the problem of consumptive disease.
Drawings
Fig. 1 is a flow chart of a preparation method of a drug-separated moxibustion medicine for benefiting the internal organs according to an embodiment of the present invention.
Fig. 2 is a schematic diagram illustrating the comparison of physical fatigue integrals of patients according to the embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a drug-separating moxibustion medicine for tonifying internal organs and a preparation method thereof, and the invention is described in detail with reference to the accompanying drawings.
The invention provides a medicine-separating moxibustion medicine for tonifying viscera, which consists of 6g of astragalus, 6g of codonopsis pilosula, 6g of poria, 6g of bighead atractylodes rhizome, 6g of angelica, 6g of ligusticum wallichii, 6g of prepared rehmannia root, 6g of white peony root, 6g of vinegar radix bupleuri, 3g of cinnamon, 3g of curculigo orchioides, 3g of epimedium, 3g of coptis chinensis, 3g of cape jasmine and 3g of radix curcumae.
As shown in FIG. 1, the preparation method of the drug-separated moxibustion medicine for tonifying the internal organs provided by the invention comprises the following steps:
s101: collecting 6g of angelica and 6g of ligusticum wallichii, performing steam distillation on the angelica and the ligusticum wallichii to collect volatile oil and distilled residual liquid, taking medicine residues, adding water into the medicine residues, decocting the medicine residues, filtering the medicine residues, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating the filtrate to obtain first stock solution for later use.
S102: heating and refluxing 6g of radix scutellariae and 6g of rhizoma atractylodis macrocephalae by 60-95 vol% ethanol, collecting an extracting solution, decocting the medicine residues in water, filtering, collecting a filtrate, mixing the extracting solution and the filtrate, and concentrating to obtain a second stock solution for later use.
S103: cutting 6g of radix codonopsis, 6g of radix paeoniae alba and 6g of vinegar radix bupleuri into pieces, adding 7-10 times of pure water, decocting for 2-3 times, 2-3 hours each time, filtering, collecting filtrate, concentrating under reduced pressure to obtain a semi-fluid, standing, and cooling to obtain a third stock solution for later use.
S104: removing impurities from Poria 6g, drying, mixing, decocting with water, and filtering to obtain first decoction and residue; decocting the residue to obtain a second decoction; mixing the two decoctions, concentrating to obtain semi-fluid, standing, and cooling to obtain fourth stock solution.
S105: taking 6g of radix rehmanniae preparata, frying for 13 minutes by using slow fire, crushing into powder of 200-300 meshes, adding 2-3 times of volume of water for ultrasonic extraction for 1-3 times, concentrating an extracting solution to 1/3-1/2 volume, adsorbing and decoloring by using activated carbon, extracting by using ethyl acetate, extracting an extracted water phase by using chloroform, extracting an extracted water phase by using n-butyl alcohol, concentrating an extracting solution to obtain a semi-fluid, standing and cooling to obtain a fifth stock solution for later use.
S106: taking 3g of cinnamon, adding an aqueous solvent for soaking extraction, and respectively collecting a cinnamon raw material and a soaking extracting solution after soaking extraction; adding ethanol into the soaked and extracted cinnamon raw material for reflux extraction, and respectively collecting the cinnamon raw material and the reflux extracting solution after reflux extraction; mixing the soaking extract and the refluxing extract, concentrating to obtain a semi-fluid, standing, and cooling to obtain a sixth stock solution for later use.
S107: crushing 3g of rhizoma curculiginis, sieving, mixing 1 part by weight of rhizoma curculiginis powder obtained by crushing with 0.5 part by weight of diatomite, adding the mixture into an extraction tank for static extraction, extracting by adopting a rapid solvent extraction method to obtain an extract, concentrating to obtain a semi-fluid, standing and cooling to obtain a seventh stock solution for later use.
S108: extracting 3g of epimedium herb with water, precipitating with ethanol, concentrating the obtained supernatant under reduced pressure, concentrating to obtain a semi-fluid, standing, and cooling to obtain an eighth stock solution for later use.
S109: pulverizing Coptidis rhizoma 3g, ultrasonic extracting for 30-45min with 10-15 times of 75-95% ethanol, standing the extractive solution for 5-10h, filtering to obtain filtrate, concentrating to obtain semi-fluid, standing, and cooling to obtain ninth stock solution.
S110: placing 3g of fructus Gardeniae on a manual operation table, removing impurities, fruit stalks, branches and stalks and other non-medicinal parts, placing in a microwave generator, taking out, and grinding; adding 7-10 times of pure water, decocting for 2-3 times, each time for 2-3 hr, filtering, collecting filtrate, concentrating under reduced pressure to obtain semi-fluid, standing, and cooling to obtain tenth stock solution.
S111, performing CO2 supercritical extraction on 3g of radix curcumae to obtain a radix curcumae extract and a radix curcumae extract residue, clathrating the extract with β -cyclodextrin to obtain a clathrate, performing alcohol extraction, filtering to obtain alcohol extraction residues and filtrate, concentrating the filtrate to obtain an alcohol extraction extract, mixing and concentrating the alcohol extraction extract and the clathrate to obtain a semi-fluid, standing and cooling to obtain an eleventh stock solution for later use.
S112: and mixing the first stock solution and the eleventh stock solution, placing the mixture in a stirrer to be stirred for 20-25min, and placing the mixture in a drying device to be dried by using high-temperature flue gas after stirring.
In S101, steam distillation is performed for 1-2 times, each time lasts for 2-10 hours, and the first decoction is that the mass-to-volume ratio of the first decoction dregs to water is 1: 6-12 in g: m L.
In S102, ethanol is refluxed for 1-3 times, each time is 1-5 hours, and the second decoction is that the mass-to-volume ratio of the second decoction dregs to water is 1: 6-12 in terms of g: m L.
In S104, the first decoction time is 5 hours, the temperature is 60-70 ℃, the water volume is 1.5 times of the volume for submerging all medicinal materials, the second decoction time is 3 hours, the temperature is 60-70 ℃, and the water volume is based on submerging the medicinal materials.
In S107, the weight ratio of the extraction solvent is 2: 8, extracting at 100 ℃ by using a mixed solution of isopropanol and methanol; static extraction time is 5 min; the volume of the rinse is 100%; number of static cycles 1.
In S110, the optimum microwave drying power is 600w, and heating is carried out for 40S.
In S111, the supercritical CO2 extraction conditions comprise that the extraction pressure is 25-35MPa, the extraction temperature is 25-35 ℃, the CO2 flow is 11-15L/h, and the extraction time is 1-2h, so that the curcuma aromatica extract and the raffinate are obtained.
In S111, adding 70% -90% ethanol 6-10 times of the weight of radix Curcumae to the extract residue of radix Curcumae, reflux-extracting for 1-3 times, each for 1-2 hr, standing the reflux liquid for more than 12 hr, and collecting the supernatant.
In S111, β -cyclodextrin is included under the conditions that the ratio of the extract to β -cyclodextrin is 1ml to 3-5g, the amount of water is 4-8 times, and the inclusion time is 20-60 minutes.
In S111, β -cyclodextrin is included to obtain an inclusion compound, preferably under the inclusion condition that the weight ratio of the extract to β -cyclodextrin is 1ml:5g, 8 times of water of β -cyclodextrin is added for inclusion for 60 min.
The invention provides a use method of a drug-separated moxibustion medicine for tonifying viscera, which comprises the following steps:
s201: mashing moxibustion medicine in a mashing tank, mashing into powder, and taking out for use.
S202: shredding fresh rhizoma Zingiberis recens, decocting in water for 10min, stopping heating, and taking out;
s203: mixing the fresh ginger juice with the mashed moxibustion medicine with a glass rod to obtain a paste, and externally coating the paste.
The invention is described in detail below in connection with pharmacological assays:
astragalus root: sweet taste and mild nature, has the effects of invigorating qi, consolidating exterior, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, enhancing capillary resistance, arresting sweating and sex hormone, and can be used for treating exterior deficiency, spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency, diarrhea, edema, carbuncle, cellulitis, etc.
Codonopsis pilosula: sweet and neutral. Tonify middle-jiao and Qi, harmonize stomach and promote fluid production, dispel phlegm and relieve cough. Can be used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, spontaneous perspiration, rectocele, and abnormal yin.
Poria cocos: sweet and bland taste, mild nature, diuresis and dampness excreting, spleen strengthening and heart calming, and is used for edema oliguria, phlegm and fluid retention, dizziness and palpitation, spleen deficiency and poor appetite, loose stool and diarrhea, uneasiness, palpitation and insomnia.
White atractylodes rhizome: bitter, sweet and warm. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, dyspepsia, diarrhea, edema, spontaneous perspiration, and threatened abortion.
Chinese angelica: sweet and warm in flavor, and can enrich the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.
Ligusticum wallichii: pungent and warm in flavor, and can be used for promoting qi circulation, relieving depression, dispelling wind-dryness and dampness, promoting blood circulation and relieving pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Prepared rhizome of rehmannia: sweet, slightly warm, nourishing yin, tonifying blood. It is indicated for deficiency of yin and blood, atrophy and weakness of waist and knees, fatigue, cough, steaming bone, seminal emission, metrorrhagia, menoxenia, diabetes, scanty urine, deafness and blurred vision.
White peony root: pungent, sweet and warm; and (5) small toxicity. Dispel wind-damp, tonify kidney, strengthen spleen, relieve snake and dog poison.
Vinegar processed bupleurum root: bitter and slightly cold. Enter liver and gallbladder meridians, harmonize exterior and interior, sooth liver and raise yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, prolapse of son and sense organs, and proctoptosis.
Cinnamon: the medicine has pungent and sweet taste, is large in nature and hot, enters kidney, spleen, heart and liver channels, has the effects of tonifying fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals, and is used for treating impotence, cold womb, cold pain of waist and knees, asthma due to kidney deficiency, floating of deficiency yang, dizziness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia and abdominal pain, dysmenorrheal and amenorrhea.
Rhizoma curculiginis: warming kidney yang and strengthening body; dispel cold-dampness. Impotence and cold essence; urinary incontinence; abdominal cold pain; soreness of the waist and knees; the muscles and bones are weak; contracture of the lower limbs; climacteric syndrome.
Herba epimedii: the flavor is pungent, sweet and warm, and can move along the liver and kidney meridians. It is the essential herb for tonifying the vital gate, benefiting essence and qi, strengthening tendons and bones, tonifying kidney and strengthening yang.
Coptis chinensis: clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.
Gardenia: bitter in nature and cold in nature, entering heart, lung and triple energizer meridians, purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and removing toxicity; it has repercussive and analgesic effects, and can be used for treating vexation due to febrile disease, jaundice due to damp-heat, stranguria, hematemesis, epistaxis, conjunctival congestion, swelling and pain, pyocutaneous disease due to pathogenic fire, and sprain, contusion and pain.
Turmeric root-tuber: pungent, bitter and cold in property, entering liver, heart and lung meridians, promoting blood circulation to arrest pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and removing jaundice, and can be used for treating stabbing pain in chest and hypochondrium, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, breast pain, fever unconsciousness, epilepsy, hematemesis, epistaxis, jaundice, and dark urine.
Astragalus, radix codonopsis, poria and bighead atractylodes rhizome have the effects of tonifying spleen and qi, prepared rehmannia root and white paeony root have the effects of enriching blood and nourishing yin, cinnamon, rhizoma curculiginis and epimedium have the effects of tonifying kidney and strengthening yang, and a plurality of tonifying medicaments have the effects of regulating and nourishing qi, blood and yin of viscera, relieving the fatigue state of the organism, activating yang-qi and enhancing the vitality; zhi Zi is good at purging triple energizer fire, clearing heart fire and relieving restlessness; the angelica sinensis has the functions of tonifying qi and activating blood, and the ligusticum wallichii has the functions of promoting qi and activating blood, dispelling wind and relieving pain; the radix bupleuri and the radix curcumae are used for relieving depression, so that depression symptoms of CFS patients can be relieved, and the recipe has the effects of reducing diarrhea in tonifying, and avoiding the phenomenon of fire-heat attack due to excessive tonifying.
The technical effects of the present invention will be described in detail with reference to specific embodiments.
The zang-fu moxibustion group of the embodiment of the invention is included in 36 cases, 3 cases are removed, 1 case is removed, and 32 cases are actually completed, wherein 17 cases of men and 15 cases of women are aged 26 years old for the youngest, 50 years old for the biggest, 38.97 + -6.98 years old for the average age, and 15.72 + -5.20 months old for the average course of disease.
The acupuncture group included 36 patients and dropped 6 patients, and actually completed 30 patients, wherein 13 men and 17 women had an age of 25 years in the youngest patients, 48 years in the largest patients, an average age of 37.73 + -6.26 years, and an average course of disease of 15.23 + -5.40 months.
TABLE 1 comparison of gender distributions of two groups of patients (n)
Table 1 shows, by statistical analysis,%20.594, P > 0.05 (0.441), with no significant difference.
TABLE 2 comparison of age distributions of two groups of patients (n, n,
)
Table 2 shows the statistical analysis χ21.557, P > 0.05 (0.459), with no significant difference.
TABLE 3 comparison of the course of disease for two groups of patients (n, n,
)
Table 3 shows the statistical analysis χ20.639, P > 0.05(P ═ 0.726), with no significant difference.
Comparison of two sets of body fatigue integrals
TABLE 4 comparison of two sets of body fatigue integrals
Note: # denotes comparison after 1 treatment session with pre-treatment session for the same group, # denotes comparison after 2 treatment sessions with post 1 treatment session for the same group, & denotes comparison after 2 treatment sessions with pre-treatment session for the same group.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. The medicine-separated moxibustion medicine for tonifying viscera is characterized by consisting of 6g of astragalus root, 6g of codonopsis pilosula, 6g of poria, 6g of bighead atractylodes rhizome, 6g of angelica, 6g of ligusticum wallichii, 6g of prepared rehmannia root, 6g of white peony root, 6g of vinegar radix bupleuri, 3g of cinnamon, 3g of rhizoma curculiginis, 3g of epimedium herb, 3g of coptis chinensis, 3g of cape jasmine and 3g of radix curcumae.
2. The method for preparing the viscera-invigorating and drug-separating moxibustion medicine as claimed in claim 1, wherein the preparation method of the viscera-invigorating and drug-separating moxibustion medicine comprises the following steps:
step one, distilling 6g of angelica and 6g of ligusticum wallichii by water vapor to collect volatile oil and distilled residual liquid, decocting the residues with water, filtering, collecting filtrate, mixing the filtrate with the distilled residual liquid, and concentrating to obtain a first stock solution for later use;
step two, taking 6g of radix scutellariae and 6g of rhizoma atractylodis macrocephalae, heating and refluxing the radix scutellariae and the 6g of rhizoma atractylodis macrocephalae through 60-95 vol% ethanol, collecting an extracting solution, taking medicine residues, adding water, decocting the medicine residues, filtering the decoction, collecting filtrate, mixing the extracting solution and the filtrate, and concentrating the mixture to obtain a second stock solution for later use;
taking 6g of codonopsis pilosula, 6g of white paeony root and 6g of vinegar radix bupleuri, cutting into pieces, adding 7-10 times of pure water, decocting for 2-3 times, 2-3 hours each time, filtering, collecting filtrate, concentrating the filtrate under reduced pressure to obtain a semi-fluid, standing and cooling to obtain a third stock solution for later use;
step four, removing impurities from 6g of poria, drying, uniformly mixing, adding water for decoction, and filtering to obtain a first decoction and medicinal material residues; decocting the residue to obtain a second decoction; mixing the two decoctions, concentrating to obtain a semi-fluid, standing, and cooling to obtain a fourth stock solution;
step five, taking 6g of prepared rehmannia root, frying for 13 minutes by using slow fire, crushing into powder of 200-300 meshes, adding 2-3 times of volume of water for ultrasonic extraction for 1-3 times, concentrating an extracting solution to 1/3-1/2 volume, adsorbing and decoloring by using activated carbon, extracting by using ethyl acetate, extracting an extracted water phase by using chloroform, extracting the extracted water phase by using n-butyl alcohol to obtain an extracting solution, concentrating the extracting solution into a semi-fluid, standing and cooling to obtain a fifth stock solution for later use; step six, taking 3g of cinnamon, adding an aqueous solvent for soaking and extracting, and respectively collecting the cinnamon raw material and the soaking extract after soaking and extracting; adding ethanol into the soaked and extracted cinnamon raw material for reflux extraction, and respectively collecting the cinnamon raw material and the reflux extracting solution after reflux extraction; mixing the soaking extract and the refluxing extract, concentrating to obtain a semi-fluid, standing, and cooling to obtain a sixth stock solution for later use;
step seven, crushing and sieving 3g of rhizoma curculiginis, mixing 1 part by weight of rhizoma curculiginis powder obtained by crushing with 0.5 part by weight of diatomite, adding the mixture into an extraction tank for static extraction, extracting by adopting a rapid solvent extraction method to obtain an extract, concentrating to a semi-fluid, standing and cooling to obtain a seventh stock solution for later use;
step eight, extracting 3g of epimedium herb with water, precipitating with ethanol, concentrating the obtained supernatant under reduced pressure, concentrating to obtain a semi-fluid, standing and cooling to obtain an eighth stock solution for later use;
step nine, crushing 3g of coptis chinensis, carrying out ultrasonic extraction for 30-45min, standing an extracting solution for 5-10h and filtering to obtain a filtrate, concentrating the filtrate into a semi-fluid, and standing and cooling to obtain a ninth stock solution for later use, wherein the extracting solvent is 75-95% ethanol in an amount which is 10-15 times that of the extracting solution;
step ten, taking 3g of gardenia, placing the gardenia on a manual operation table, removing impurities, fruit stalks, branches and other non-medicinal parts, placing the gardenia in a microwave generator, taking out the gardenia and grinding the gardenia; adding 7-10 times of pure water, decocting for 2-3 times, each time for 2-3 hr, filtering, collecting filtrate, concentrating under reduced pressure to obtain semi-fluid, standing, and cooling to obtain tenth stock solution;
step eleven, performing CO2 supercritical extraction on 3g of radix curcumae to obtain radix curcumae extract and radix curcumae extract residues, coating the extract with β -cyclodextrin to obtain an inclusion compound, performing alcohol extraction, filtering to obtain alcohol extraction residues and filtrate, concentrating the filtrate to obtain alcohol extraction extract, mixing and concentrating the alcohol extraction extract and the inclusion compound to obtain a semi-fluid, standing and cooling to obtain an eleventh stock solution for later use;
and step twelve, mixing the first stock solution and the eleventh stock solution, placing the mixture into a stirrer to be stirred for 20-25min, and placing the mixture into a drying device to be dried by using high-temperature flue gas after stirring.
3. The method for preparing a drug-separated moxibustion medicine for tonifying viscera according to claim 2, wherein in the first step, the steam distillation is carried out for 1-2 times, each time for 2-10 h, and the first decoction is carried out in a mass-to-volume ratio of the first decoction dregs to water of 1: 6-12 in g: m L.
4. The method for preparing a drug-separated moxibustion medicine for tonifying viscera according to claim 2, wherein in the second step, the ethanol is refluxed for 1 to 3 times and each time lasts for 1 to 5 hours, and the second decoction is carried out in a mass-to-volume ratio of the second decoction dregs to water of 1:6 to 12 in g: m L.
5. The method for preparing a drug-separated moxibustion medicine for tonifying the zang-fu organs as claimed in claim 2, wherein in the fourth step, the first decoction is carried out for 5 hours at 60-70 ℃ with water amount of 1.5 times of the volume of the medicine submerged therein, and the second decoction is carried out for 3 hours at 60-70 ℃ with water amount of the medicine submerged therein.
6. The method for preparing a drug-separated moxibustion medicine for tonifying the zang-fu according to claim 2, wherein in step seven, the weight ratio of the extraction solvent is 2: 8, extracting at 100 ℃ by using a mixed solution of isopropanol and methanol; static extraction time is 5 min; the volume of the rinse is 100%; number of static cycles 1.
7. The method for preparing a drug-separated moxibustion medicine for tonifying the zang-fu according to claim 2, wherein in the tenth step, the optimum microwave drying power is 600w and the heating is carried out for 40 s.
8. The method for preparing a drug-separated moxibustion medicine for tonifying viscera as claimed in claim 2, wherein in the eleventh step, the supercritical CO2 extraction is performed under the conditions of 25-35MPa of extraction pressure, 25-35 ℃ of extraction temperature, 11-15L/h of CO2 flow and 1-2h of extraction time to obtain the curcuma aromatica extract and the raffinate, the curcuma aromatica raffinate is extracted by adding 70-90% ethanol which is 6-10 times of the weight of the curcuma aromatica medicinal material into the curcuma aromatica extract for reflux for 1-3 times, each time lasts for 1-2h, the reflux liquid is kept stand for more than 12 h, and the supernatant is extracted.
9. The method for preparing a drug-separated moxibustion medicine for tonifying viscera according to claim 2, wherein in the eleventh step, the β -cyclodextrin is included under the conditions that the ratio of the extract to β -cyclodextrin is 1ml:3-5g, the amount of water is 4-8 times that of the extract, the inclusion time is 20-60 minutes, and β -cyclodextrin is included to obtain the inclusion compound, preferably under the conditions that the weight ratio of the extract to β -cyclodextrin is 1ml:5g, and the amount of water is 8 times that of β -cyclodextrin is added, and the inclusion is 60 minutes.
10. The method of claim 1, wherein the method of applying the zang-fu tonifying drug-partitioning moxibustion medicine comprises:
firstly, taking moxibustion medicine, mashing the moxibustion medicine into powder by using a mashing tank, and taking out the powder for later use;
step two, shredding fresh ginger, putting into a pot, adding water for boiling, stopping heating after boiling for 10min, and taking out;
and step three, mixing the fresh ginger juice taken out and the mashed moxibustion medicine into paste by using a glass rod, and externally coating the paste.
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