CN103463388A - Medicinal composition for treating turtle scabies disease and preparation method thereof - Google Patents
Medicinal composition for treating turtle scabies disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating a turtle scabies disease, comprises the following Chinese herbs in parts by weight: 15-30 parts of yam rhizome, 20-30 parts of honeysuckle, 5-15 parts of gallnut, 10-25 parts of golden cypress, 2-10 parts of wild chrysanthemum flower and 5-15 parts of onion. The invention further discloses a preparation of the medicinal composition. The effective component berberine of the yam rhizome and effective components chlorogenic acid and luteolin of the honeysuckle have a very strong anti-virus effect, so that the medicinal composition has an effective effect as high as 99%. In the preparation method, the effective component of the yam rhizome is extracted with a supercritical carbon dioxide extraction method, so that the extraction amount of the berberine is 6.8%-7.5% of the weight of the yam rhizome; the extraction amount of the chlorogenic acid in the honeysuckle is 2%-3.5% of the weight of the honeysuckle; and the extraction amount of the luteolin in the honeysuckle is 0.08%-0.1% of the weight of the honeysuckle.
Description
Technical field
The present invention relates to treat the field of Chinese medicines of Trionyx sinensis Wiegmann disease, be specifically related to a kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease and preparation method thereof.
Background technology
Trionyx sinensis Wiegmann scabies disease also is stigmatosis, and cause of disease is an aerogenesis Zymomonas mobilis point-like subspecies.When cultivating condition worsens, feedstuff corruption or hypotrophy face, Trionyx sinensis Wiegmann mutually bites and stings when injured, and this pathogen very easily infects and makes Trionyx sinensis Wiegmann sick.Sick Trionyx sinensis Wiegmann cervical region of initial stage, back of the body sternite, shirt rim, extremity base portion length have the white scabies of or several Semen Glycines sizes, scabies increases gradually later, outwards outstanding, final skin breakage, now, by hands extruding surrounding, can extrude the content that stench flavor was strengthened, had to the strong or Glycine max (L.) Merr. of yellow-white granule, some yellow particle in content is easily pressed, after putting into water, can be dispersed into the strong thing of powder.The state of an illness further develops, and scabies is from bursting, and content is scattered, and inflammation extends, and skin ulceration becomes cave, causes ulcer disease and shothole disease concurrent.But it is dead generally not arrive this sick Trionyx sinensis Wiegmann.Sick Trionyx sinensis Wiegmann is subcutaneous, there is yellow mucus in oral cavity, trachea, and the subcutaneous glue sample that is of abdominal part and cervical region is invaded profit, pulmonary congestion; Black dull or the brown of liver, slightly enlargement, matter is broken; The gallbladder kind is large; The spleen hemorrhage; The nephremia or hemorrhage, intestinal is slightly congested, and more mucus is arranged in body cavity.Suffer from the sick Trionyx sinensis Wiegmann whole body of this disease uneasiness; Loss of appetite or do not ingest, body constitution is become thin, the food platform that often reposes, head can not return, and eye can not be opened, decline and death.Also ill Trionyx sinensis Wiegmann is invaded blood because of pathogen, along speed, is diffused into whole body, acute death occurs.Even not dead sick Trionyx sinensis Wiegmann also can be because of its commodity value of the injured reduction of its external form after curing.
This disease all can be infected from young Trionyx sinensis Wiegmann to Trionyx sinensis, especially larger to the harm of inmature Trionyx sinensis Wiegmann, and body weight is that the following young Trionyx sinensis sickness rate of 20 grams can reach 10%～50%, if treat, takes effective measures, will be dead about 15 days; The above Trionyx sinensis Wiegmann of 250 grams can reach 30%～40% because this disease infects mortality rate.This sick epidemic season is 5～JIUYUE, if temperature is high, also can continue popular October; 5～July of onset peak; This disease is also the normal disease occurred of greenhouse cultivation.The popular temperature of this disease is 20～30 ℃, this sick as easy as rolling off a log generation of 30 ℃ of left and right of water temperature.
According to sick Trionyx sinensis Wiegmann body surface scabies focus, can tentatively judge; The smears such as the strong thing of HUANGBAI(sic) toner with aseptic means by the liver of dying Trionyx sinensis Wiegmann, kidney, blood, ascites or not shattered to pieces scabies, fixing, Gram’s staining, if find, more size is similar, the brevibacterium of two ends red coloration can be made a definite diagnosis substantially; With this, the content of sick positive serum and its focus is done the cohesion experiment, and positive, be this disease.
Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), antimicrobial and protozoacide effect, in vitro tests proves, Rhizoma Coptidis or berberine all have stronger bacteriostasis to Hemolytic streptococcus, meningococcus, Diplococcus pneumoniae, vibrio cholera, anthrax bacillus and staphylococcus aureus; Dysentery bacterium, diphtheria corynebacterium, bacillus subtilis, viridans streptococci are all had to inhibitory action; Also effective to pneumobacillus, bordetella pertussis, bacillus pestis, Brucella, clostridium tetani, bacillus perfringens, tubercule bacillus etc.; Bacillus proteus, escherichia coli, Bacillus typhi are acted on poor, to sonne bacillus, Salmonella paratyphi, bacillus pyocyaneus several without the effect.Due to the difference of experimental technique, some difference is reported by each family.To dysentery bacterium, higher with the sensitivity of the Shigella flexneri that relaxes, secondly Fu Shi, Song Nei Shi are the poorest.Its effect is parity with or superiority over sulfanilamide and is weaker than streptomycin and chloromycetin.The antibacterial action of Rhizoma Coptidis crude extract and pure berberine is consistent basically; But a few cases is also arranged, not quite identical to the effect of certain antibacterial.
The Flos Lonicerae effect is as follows: the one, and antibiotic and antiviral.Staphylococcus aureus, Hemolytic streptococcus, dysentery, typhoid fever, meningococcus, Diplococcus pneumoniae, green pus and influenza virus etc. are had to obvious inhibitory action.The 2nd, have and strengthen immune function.Flos Lonicerae can promote lymphocyte transformation, strengthens leukocytic phagocytic function.The 3rd, antiinflammatory, analgesic.Flos Lonicerae can promote the release of adrenocortical hormone, and inflammation is had to obvious inhibitory action.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, first purpose of the present invention is to provide a kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease.Second purpose of the present invention is to provide the preparation method of this pharmaceutical composition.
Technical scheme: in order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease, comprise following Chinese medicine, its parts by weight are respectively: 15 ~ 30 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 20 ~ 30 parts of Flos Loniceraes, 5 ~ 15 parts of Galla Chinensiss, 10 ~ 25 parts of Cortex Phellodendris, 2 ~ 10 parts of Flos Chrysanthemi Indicis, 5 ~ 15 parts of Bulbus Allii Cepaes.
Preferably, its parts by weight are respectively: 20 ~ 30 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 25 ~ 30 parts of Flos Loniceraes, 10 ~ 15 parts of Galla Chinensiss, 20 ~ 25 parts of Cortex Phellodendris, 6 ~ 10 parts of Flos Chrysanthemi Indicis, 10 ~ 15 parts of Bulbus Allii Cepaes.
More preferably, its parts by weight are respectively: 20 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 25 parts of Flos Loniceraes, 10 parts of Galla Chinensiss, 20 parts of Cortex Phellodendris, 6 parts of Flos Chrysanthemi Indicis, 10 parts of Bulbus Allii Cepaes.
The preparation method of described pharmaceutical composition comprises the following steps:
1) Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) taken by above-mentioned parts by weight adds 80% ethanol of 10 ~ 15 times of amounts of its weight, adopts supercritical CO
2extraction obtains the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient;
2) take Flos Lonicerae by above-mentioned parts by weight and add 75% ethanol of 10 ~ 15 times of amounts of its weight to carry out alcohol reflux, extract 5 times, each 2.5h obtains effective ingredient of honeysuckle;
3) take Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae by above-mentioned parts by weight and add 20 ~ 25 times of decoctings of Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient, the step 2 of step 1)) effective ingredient of honeysuckle and the supernatant of step 3) mix the pharmaceutical composition of the Trionyx sinensis Wiegmann scabies disease that obtains medical treatment.
Described Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient is isoquinoline alkaloid.
Described isoquinoline alkaloid Berberine content extracted amount is 6.8% ~ 7.5% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight.
Described effective ingredient of honeysuckle is chlorogenic acid and luteoloside, and the extracted amount of its Content of Chlorogenic Acid is Flos Lonicerae 2% ~ 3.5%, and the extracted amount of described Luteolin content is Flos Lonicerae 0.08% ~ 0.1%.
Described supercritical CO
2extraction conditions is: 50 ~ 60 ℃ of temperature, pressure are that 27 ~ 30MPa, quiet hour are 2h, and dynamic time is 1.5h.
Beneficial effect: a kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease provided by the invention, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient berberine wherein, effective ingredient of honeysuckle is that chlorogenic acid and luteoloside have very strong antiviral effect, this pharmaceutical composition can prevent and treat Trionyx sinensis Wiegmann scabies disease well, and treated effect is up to 99%.In preparation method of the present invention, the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) extracts active ingredients has adopted supercritical CO
2extracting method, making the content of berberine extracted amount is 6.8% ~ 7.5% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight; The extracted amount of Chlorogenic Acid of Flos Lonicerae content is 2% ~ 3.5% of Flos Lonicerae, and the extracted amount of described Luteolin content is Flos Lonicerae 0.08% ~ 0.1%.Simple, the applicable large-scale production of preparation method of the present invention.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
embodiment 1:
A kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease, comprise following Chinese medicine, and its parts by weight are respectively: 15 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 20 parts of Flos Loniceraes, 5 parts of Galla Chinensiss, 10 parts of Cortex Phellodendris, 2 parts of Flos Chrysanthemi Indicis, 5 parts of Bulbus Allii Cepaes.
The preparation method of described pharmaceutical composition comprises the following steps:
1) Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) taken by above-mentioned parts by weight adds 80% ethanol of 10 times of amounts of its weight, adopts supercritical CO
2extraction obtains the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient;
2) take Flos Lonicerae by above-mentioned parts by weight and add 75% ethanol of 10 times of amounts of its weight to carry out alcohol reflux, extract 5 times, each 2.5h obtains effective ingredient of honeysuckle;
3) take Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae by above-mentioned parts by weight and add 20 times of decoctings of Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae gross weight to boil 2h, filter, obtain supernatant;
4) by Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient, the step 2 of step 1)) effective ingredient of honeysuckle and the supernatant of step 3) mix the pharmaceutical composition of the Trionyx sinensis Wiegmann scabies disease that obtains medical treatment.
Described Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient is isoquinoline alkaloid.
Described isoquinoline alkaloid Berberine content extracted amount is 6.8% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight.
Described effective ingredient of honeysuckle is chlorogenic acid and luteoloside, and the extracted amount of its Content of Chlorogenic Acid is Flos Lonicerae 2%, and the extracted amount of described Luteolin content is Flos Lonicerae 0.08%.
Described supercritical CO
2extraction conditions is: temperature 50 C, pressure are that 27MPa, quiet hour are 2h, and dynamic time is 1.5h.
embodiment 2:
A kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease, comprise following Chinese medicine, and its parts by weight are respectively: 30 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 30 parts of Flos Loniceraes, 15 parts of Galla Chinensiss, 25 parts of Cortex Phellodendris, 10 parts of Flos Chrysanthemi Indicis, 15 parts of Bulbus Allii Cepaes.
The preparation method of described pharmaceutical composition comprises the following steps:
1) Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) taken by above-mentioned parts by weight adds 80% ethanol of 15 times of amounts of its weight, adopts supercritical CO
2extraction obtains the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient;
2) take Flos Lonicerae by above-mentioned parts by weight and add 75% ethanol of 15 times of amounts of its weight to carry out alcohol reflux, extract 5 times, each 2.5h obtains effective ingredient of honeysuckle;
3) take Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae by above-mentioned parts by weight and add 25 times of decoctings of Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient, the step 2 of step 1)) effective ingredient of honeysuckle and the supernatant of step 3) mix the pharmaceutical composition of the Trionyx sinensis Wiegmann scabies disease that obtains medical treatment.
Described Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient is isoquinoline alkaloid.
Described isoquinoline alkaloid Berberine content extracted amount is 7.5% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight.
Described effective ingredient of honeysuckle is chlorogenic acid and luteoloside, and the extracted amount of its Content of Chlorogenic Acid is Flos Lonicerae 3.5%, and the extracted amount of described Luteolin content is Flos Lonicerae 0.1%.
Described supercritical CO
2extraction conditions is: temperature 60 C, pressure are that 30MPa, quiet hour are 2h, and dynamic time is 1.5h.
embodiment 3:
A kind of pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease, comprise following Chinese medicine, and its parts by weight are respectively: 20 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 25 parts of Flos Loniceraes, 10 parts of Galla Chinensiss, 20 parts of Cortex Phellodendris, 6 parts of Flos Chrysanthemi Indicis, 10 parts of Bulbus Allii Cepaes.
The preparation method of described pharmaceutical composition comprises the following steps:
1) Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) taken by above-mentioned parts by weight adds 80% ethanol of 10 ~ 15 times of amounts of its weight, adopts supercritical CO
2extraction obtains the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient;
2) take Flos Lonicerae by above-mentioned parts by weight and add 75% ethanol of 10 ~ 15 times of amounts of its weight to carry out alcohol reflux, extract 5 times, each 2.5h obtains effective ingredient of honeysuckle;
3) take Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae by above-mentioned parts by weight and add 20 ~ 25 times of decoctings of Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient, the step 2 of step 1)) effective ingredient of honeysuckle and the supernatant of step 3) mix the pharmaceutical composition of the Trionyx sinensis Wiegmann scabies disease that obtains medical treatment.
Described Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient is isoquinoline alkaloid.
Described isoquinoline alkaloid Berberine content extracted amount is 6.8% ~ 7.5% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight.
Described effective ingredient of honeysuckle is chlorogenic acid and luteoloside, and the extracted amount of its Content of Chlorogenic Acid is Flos Lonicerae 2% ~ 3.5%, and the extracted amount of described Luteolin content is Flos Lonicerae 0.08% ~ 0.1%.
Described supercritical CO
2extraction conditions is: 50 ~ 60 ℃ of temperature, pressure are that 27 ~ 30MPa, quiet hour are 2h, and dynamic time is 1.5h.
The embodiment of the present invention 1 ~ 3 any one pharmaceutical composition usage and consumption: the sick burst period of Trionyx sinensis Wiegmann scabies, splash comprehensively, every 1 cubic metre of water body medication 1.3 ~ 2.7g, every mu of pharmaceutical composition 1600 ~ 1800g of the present invention for water body depth of water 1m, be used in conjunction 3 days.
Experimental condition:
The category-A cultivating pool: 1 mu of area, 1.7 meters of water depths, water source is that Yangtze River Water, pH are 7.0, water temperature is 25 ℃.30 of this pond Trionyx sinensis Wiegmanns, average weight are 550g.
The category-B cultivating pool: 0.9 mu of area, 1.6 meters of water depths, water source is that Yangtze River Water, pH are 7.0, water temperature is 25 ℃.30 of this pond Trionyx sinensis Wiegmanns, average weight are 552g.
Test method:
Category-A pond medication 1.8kg, first day is 1 Trionyx sinensis Wiegmann in the dust, second day medication 1.8kg, the Trionyx sinensis Wiegmann scabies is sick to be improved, the 3rd day medication 1.8kg, the Trionyx sinensis Wiegmann scabies is sick cures, and movable and feed recovers normal condition.
The category-B pond does not have medication, and first day is 8 Trionyx sinensis Wiegmanns in the dust, 10 in the dust of second days, the 3rd day 12 in the dust.
Result of the test:
The category-A pond is 1 Trionyx sinensis Wiegmann scabies disease in the dust, and cure rate is 99%, the not medication of category-B pond, and mortality rate increases, last all dead.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. a pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease, is characterized in that, comprises following Chinese medicine, and its parts by weight are respectively: 15 ~ 30 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 20 ~ 30 parts of Flos Loniceraes, 5 ~ 15 parts of Galla Chinensiss, 10 ~ 25 parts of Cortex Phellodendris, 2 ~ 10 parts of Flos Chrysanthemi Indicis, 5 ~ 15 parts of Bulbus Allii Cepaes.
2. the pharmaceutical composition for the treatment of according to claim 1 Trionyx sinensis Wiegmann scabies disease, it is characterized in that, comprise following Chinese medicine, its parts by weight are respectively: 20 ~ 30 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 25 ~ 30 parts of Flos Loniceraes, 10 ~ 15 parts of Galla Chinensiss, 20 ~ 25 parts of Cortex Phellodendris, 6 ~ 10 parts of Flos Chrysanthemi Indicis, 10 ~ 15 parts of Bulbus Allii Cepaes.
3. the pharmaceutical composition for the treatment of Trionyx sinensis Wiegmann scabies disease according to claim 1, is characterized in that, comprise following Chinese medicine, its parts by weight are respectively: 20 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 25 parts of Flos Loniceraes, 10 parts of Galla Chinensiss, 20 parts of Cortex Phellodendris, 6 parts of Flos Chrysanthemi Indicis, 10 parts of Bulbus Allii Cepaes.
4. the preparation method of the described pharmaceutical composition of claim 1 ~ 3 any one, is characterized in that, comprises the following steps:
1) Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) taken by above-mentioned parts by weight adds 80% ethanol of 10 ~ 15 times of amounts of its weight, adopts supercritical CO
2extraction obtains the Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient;
2) take Flos Lonicerae by above-mentioned parts by weight and add 75% ethanol of 10 ~ 15 times of amounts of its weight to carry out alcohol reflux, extract 5 times, each 2.5h obtains effective ingredient of honeysuckle;
3) take Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae by above-mentioned parts by weight and add 20 ~ 25 times of decoctings of Galla Chinensis, Cortex Phellodendri, Flos Chrysanthemi Indici, Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient, the step 2 of step 1)) effective ingredient of honeysuckle and the supernatant of step 3) mix the pharmaceutical composition of the Trionyx sinensis Wiegmann scabies disease that obtains medical treatment.
5. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, described Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) effective ingredient is isoquinoline alkaloid.
6. the preparation method of pharmaceutical composition according to claim 5, is characterized in that, described isoquinoline alkaloid Berberine content extracted amount is 6.8% ~ 7.5% of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) weight.
7. the preparation method of pharmaceutical composition according to claim 4, it is characterized in that, described effective ingredient of honeysuckle is chlorogenic acid and luteoloside, and the extracted amount of its Content of Chlorogenic Acid is Flos Lonicerae 2% ~ 3.5%, and the extracted amount of described Luteolin content is Flos Lonicerae 0.08% ~ 0.1%.
8. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, described supercritical CO
2extraction conditions is: 50 ~ 60 ℃ of temperature, pressure are that 27 ~ 30MPa, quiet hour are 2h, and dynamic time is 1.5h.
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| CN114129634A (en) * | 2021-11-24 | 2022-03-04 | 惠州市益晨网业科技有限公司 | Traditional Chinese medicine composition for treating fish scabies and preparation method and application thereof |
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Application publication date: 20131225 |