CN103439319A - Method for measuring bleomycins by utilizing electrochemical luminescence of carbon nanoparticle modified electrode - Google Patents
Method for measuring bleomycins by utilizing electrochemical luminescence of carbon nanoparticle modified electrode Download PDFInfo
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- CN103439319A CN103439319A CN2013103962403A CN201310396240A CN103439319A CN 103439319 A CN103439319 A CN 103439319A CN 2013103962403 A CN2013103962403 A CN 2013103962403A CN 201310396240 A CN201310396240 A CN 201310396240A CN 103439319 A CN103439319 A CN 103439319A
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- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical class N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 title claims abstract description 49
- 108010006654 Bleomycin Proteins 0.000 title claims abstract description 48
- 239000011852 carbon nanoparticle Substances 0.000 title claims abstract description 46
- 238000004020 luminiscence type Methods 0.000 title claims abstract description 17
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- 239000000523 sample Substances 0.000 claims abstract description 15
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- HOGDNTQCSIKEEV-UHFFFAOYSA-N n'-hydroxybutanediamide Chemical compound NC(=O)CCC(=O)NO HOGDNTQCSIKEEV-UHFFFAOYSA-N 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 13
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052737 gold Inorganic materials 0.000 claims description 11
- 239000010931 gold Substances 0.000 claims description 11
- YKWAWOTVGKMRAN-UHFFFAOYSA-L 2-(4-carboxylatopyridin-2-yl)pyridine-4-carboxylate;2-pyridin-2-ylpyridine;ruthenium(2+) Chemical compound [Ru+2].N1=CC=CC=C1C1=CC=CC=N1.N1=CC=CC=C1C1=CC=CC=N1.[O-]C(=O)C1=CC=NC(C=2N=CC=C(C=2)C([O-])=O)=C1 YKWAWOTVGKMRAN-UHFFFAOYSA-L 0.000 claims description 10
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- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 3
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical class [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
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- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
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- 241000187747 Streptomyces Species 0.000 description 1
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CN201310396240.3A CN103439319B (en) | 2013-09-03 | 2013-09-03 | Carbon nano-particles modified electrode electrochemiluminescence measures the method for bleomycin |
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CN201310396240.3A CN103439319B (en) | 2013-09-03 | 2013-09-03 | Carbon nano-particles modified electrode electrochemiluminescence measures the method for bleomycin |
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CN103439319A true CN103439319A (en) | 2013-12-11 |
CN103439319B CN103439319B (en) | 2015-11-04 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104007152A (en) * | 2014-06-18 | 2014-08-27 | 青岛科技大学 | DNA determining electrochemical sensor and method based on platinum nano particle catalysis electrochemistry circulation signal amplification technology |
CN105385770A (en) * | 2015-12-18 | 2016-03-09 | 山东大学 | Dual-ring hairpin probe mediate label-free strand displacement amplification method for detecting bleomycin |
CN105950757A (en) * | 2016-06-17 | 2016-09-21 | 山东大学 | Method for detecting bleomycin based on double-ring hairpin probe and enzyme-mediated cascade amplification strategy |
CN110426440A (en) * | 2019-07-16 | 2019-11-08 | 曲阜师范大学 | A kind of Photoelectrochemistrbiosensor biosensor and its detection method to BLM |
CN114487066A (en) * | 2022-01-27 | 2022-05-13 | 上海市肿瘤研究所 | Ultrasensitive DNA-biomacromolecule sensor, construction and application thereof |
-
2013
- 2013-09-03 CN CN201310396240.3A patent/CN103439319B/en not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104007152A (en) * | 2014-06-18 | 2014-08-27 | 青岛科技大学 | DNA determining electrochemical sensor and method based on platinum nano particle catalysis electrochemistry circulation signal amplification technology |
CN104007152B (en) * | 2014-06-18 | 2016-05-25 | 青岛科技大学 | Measure the method for electrochemical sensor and the mensuration DNA of DNA based on nano platinum particle catalytic electrochemical cycle signal amplifying technique |
CN105385770A (en) * | 2015-12-18 | 2016-03-09 | 山东大学 | Dual-ring hairpin probe mediate label-free strand displacement amplification method for detecting bleomycin |
CN105385770B (en) * | 2015-12-18 | 2018-09-28 | 山东大学 | The Dual-ring hairpin probe for detecting bleomycin mediates label-free strand displacement amplification method |
CN105950757A (en) * | 2016-06-17 | 2016-09-21 | 山东大学 | Method for detecting bleomycin based on double-ring hairpin probe and enzyme-mediated cascade amplification strategy |
CN105950757B (en) * | 2016-06-17 | 2019-11-22 | 山东大学 | Method based on the cascade amplification strategy detection bleomycin that Dual-ring hairpin probe and enzyme mediate |
CN110426440A (en) * | 2019-07-16 | 2019-11-08 | 曲阜师范大学 | A kind of Photoelectrochemistrbiosensor biosensor and its detection method to BLM |
CN110426440B (en) * | 2019-07-16 | 2022-02-01 | 曲阜师范大学 | Photoelectrochemistry biosensor and detection method of photoelectrochemistry biosensor for BLM |
CN114487066A (en) * | 2022-01-27 | 2022-05-13 | 上海市肿瘤研究所 | Ultrasensitive DNA-biomacromolecule sensor, construction and application thereof |
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CN103439319B (en) | 2015-11-04 |
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CB03 | Change of inventor or designer information |
Inventor after: Zheng Chuanqi Inventor before: Mixed Xu Inventor before: Liu Fang |
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TR01 | Transfer of patent right |
Effective date of registration: 20180125 Address after: 510670 Guangzhou high tech Industrial Development Zone, Guangzhou, Guangdong Province, South Yun three Road 39, eight building 2 building 201 and 202 Patentee after: Guangzhou spectrum peak Technology Co.,Ltd. Address before: 266000 Shandong province Qingdao City, No. 53 Zhengzhou Road, College of chemistry and Molecular Engineering Patentee before: QINGDAO University OF SCIENCE AND TECHNOLOGY |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151104 Termination date: 20210903 |
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