CN103431275B - Coarse grain full-nutrition formula food for hepatopath - Google Patents
Coarse grain full-nutrition formula food for hepatopath Download PDFInfo
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Abstract
The invention discloses coarse grain full-nutrition formula food for hepatopath and relates to the technical field of healthcare food. The coarse grain full-nutrition formula food is prepared by utilizing black rice, sorghum rice, oat, coix seed and whey protein powder as main raw materials, adding a Chinese medicine extracting solution, L-methionine and stevioside, and mixing and processing the ingredients. The food reinforces fine protein, L-valine, L-leucine and L-methionine on the basis of rich nutrient substances according to the special demands of hepatopath; traditional Chinese medicine ingredients are added in the food, so that the food disclosed by the invention not only has a good auxiliary curative effect on acute and chronic hepatitis, liver cirrhosis, liver ascites and the like, but also can be used as daily healthcare food for people with potential risk of liver diseases.
Description
Technical field
The present invention relates to health food technology field, be specifically related to a kind of full nutrient formulation food eating for hepatopath.
Background technology
Hepatopathy refers to the pathology that occurs in liver.Comprise hepatitis B, hepatitis A, the third liver, cirrhosis, fatization, liver cancer, alcoholic liver etc. hepatic diseases.Be the great disease of a kind of common harmfulness, should take active prevention as main.
Liver is glandula digestive maximum in human body, is the central station of substance in vivo energetic supersession.According to estimates, the chemical reaction occurring in liver has more than 500 kinds.First its secretion of bile, helps digest diet; It supplies with our human body energy the amino acid synthetic protein absorbing, and let us can complete darg lustily; It can preserve with burner body in fat, control our bodily form; It is the depot organ of liposoluble vitamin; It can also be oxidized, the toxin in reduction, decomposer, engulfs the bacterium in careless wedging body, is the removing toxic substances organ of human body maximum.
Common hepatopathy has hepatitis, cirrhosis, hepatapostema, primary carcinoma of liver etc., hepatitis mainly be take chronic hepatitis as main, by teiology, is divided into chronic viral hepatitis, oneself immunity hepatitis, drug toxicity hepatitis, genetic disease and other agnogenic chronic hepatitis.And virus hepatitis is the most common with hepatitis B, hepatitis B is a kind of pandemic infection disease, the number that hepatitis B surface antigen is carried in the whole world is according to statistics over 2.8 hundred million, China is the district occurred frequently of hepatitis B, chronic hepatitis B approximately 3,000 ten thousand people that have at present existing disease, annual domesticly die from liver cirrhosis due to hbv person have 400,000 people.
The traditional Chinese medical science thinks, hepatopathy from the beginning of, nothing more than external cause and two aspects of internal cause.External cause many due to time evil damp and hot invasion and attack and unhygienic diet; Internal cause is many because feelings will discord, overstrain internal injury have weakened Abwehrkraft des Koepers.On prevention and health care, first will be careful in one's diet nutrition and food hygiene, absorb sufficient sugar, protein, vitamin etc., sufficient to guarantee the supply of body nutriment; The unclean food of avoiding eating anything raw or cold, and to note personal hygiene, reduce the chance infecting.The internal organs theory of motherland's medical science also thinks, liver and gall and people's feelings will has close relationship, has saying of " anger is the impariment of the liver ", so the mood that keeps pleasant is broad-minded, is also an importance of prevention of liver disease.
Hepatopath, except taking in time regular treatment, should also be noted that and regulates diet partner treatment, often can obtain good result for the treatment of, and the traditional Chinese medical science is thought that hepatopath's diet should be take and put down that to mend be principle, focuses on nourishing the liver tonifying spleen.Doctor trained in Western medicine thinks that hepatopath's diet principle is:
1. high caloric diet, every day, total amount of heat generally should be lower than 8400 kilojoules (2000 kilocalories).
2. high protein diet is not only conducive to hepatocellular reparation, and to there being the patient of Hypoproteinemia and ascites more suitable.Every day, per kilogram of body weight can be supplied with 1.5 grams of protein, especially should have the good protein of sufficient amount.But cirrhosis companion hepatic coma patient in late period should reduce protein and take in.
3. should adopt low fat, few aerogenesis and low fiber meals.
4. note supplementing containing vitamin A, vitamin D, vitamin E, vitamin K, vitamin C and the abundant food of B family vitamin.
5. there is ascites person, should limit salt and take in.
6. choline, methionine etc. are super fat materials, and in the food such as millet, fine flour, milk, oat, content is abundanter, should note supplementing.
7. a small amount of many meal can increase by the 2 meal hearts outside breakfast, lunch and dinner.
8. diet should stimulate soft, easy to digest, less.
Food of the present invention just traditional Chinese and western medicine to the guidance of hepatopath's diet under; meet hepatopath to the basis of the specific (special) requirements of diet on, protein, Valine, L-Leu and the METHIONINE of further strengthening high-quality, absorption easy to digest is to strengthen the protection to liver.Chinese medicine is always subject to doctor's favor to the treatment of hepatopathy, it can be treated both principal and secondary aspect of disease, especially remarkable to chronic hepatitis effect.
Summary of the invention
The object of the invention is in order to give the hepatopaths such as acute, chronic hepatitis, cirrhosis, manufacture the full nutrient formulation food of a kind of five cereals, it can meet the specific demand of hepatopath to diet, can have certain auxiliary curing and the effect of prevention to these two kinds of hepatopathys again.
For reaching above object, the present invention is with black rice, sorghum rice, oat, heart of a lotus seed benevolence, PURE WHEY is primary raw material, add Chinese medicine extract, METHIONINE, steviol glycoside hybrid process is made, the formula of its raw material is: black rice 20-25 weight portion, sorghum rice 8-12 weight portion, oat 10-15 weight portion, heart of a lotus seed benevolence 8-12 weight portion, PURE WHEY 8-12 weight portion, Chinese medicine extract 15-20 weight portion, Valine 0.008-0.012 weight portion, L-Leu 0.02-0.04 weight portion, METHIONINE 0.015-0.025 weight portion, steviol glycoside 0.1-0.3 weight portion.Best proportioning is: black rice 22 weight portions, sorghum rice 10 weight portions, oat 13 weight portions, heart of a lotus seed benevolence 10 weight portions, PURE WHEY 10 weight portions, Chinese medicine extract 18 weight portions, Valine 0.01 weight portion, L-Leu 0.03 weight portion, METHIONINE 0.02 weight portion, steviol glycoside 0.2 weight portion.
The Chinese prescription of Chinese medicine extract is wherein: Radix Angelicae Sinensis 22-27 weight portion, fruit of glossy privet 17-22 weight portion, rascal 8-12 weight portion, fruit of Chinese wolfberry 12-17 weight portion, Fructus Aurantii 12-17 weight portion, seed of Chinese dodder 10-15 weight portion, Poria cocos 22-27 weight portion, orange peel 12-17 weight portion, rhizoma cyperi 10-15 weight portion, Ligusticum wallichii 8-12 weight portion, Chinese herbaceous peony 10-15 weight portion.Best prescription is: Radix Angelicae Sinensis 25 weight portions, the fruit of glossy privet 20 weight portions, rascal 10 weight portions, the fruit of Chinese wolfberry 15 weight portions, Fructus Aurantii 15 weight portions, the seed of Chinese dodder 12 weight portions, Poria cocos 25 weight portions, orange peel 15 weight portions, rhizoma cyperi 12 weight portions, Ligusticum wallichii 10 weight portions, Chinese herbaceous peony 12 weight portions.
Of the present invention a kind of for the edible full nutrient formulation food of five cereals of hepatopath, can obtain by following preparation technology:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis, the fruit of glossy privet, rascal, the fruit of Chinese wolfberry, Fructus Aurantii, the seed of Chinese dodder, Poria cocos, orange peel, rhizoma cyperi, Ligusticum wallichii, Chinese herbaceous peony, pulverize respectively, mix, add the purified water of 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice flour, Chinese sorghum ground rice, oatmeal, lotus-seed-heart powder, PURE WHEY, Chinese medicine extract, Valine, L-Leu, METHIONINE, steviol glycoside, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize and make finished product.
Food of the present invention can be made powdery, graininess or block food.
Of the present invention a kind of for the edible full nutrient formulation food of five cereals of hepatopath, its primary raw material has:
Black rice: black rice is the rice of a kind of medicine, food dual-purpose, belongs to glutinous rice class.Black rice appearance is pitch-dark, nutritious, has " black pearl " and " king's in world's rice " good reputation.Its nutritive value is mainly by what time following:
1) black rice is containing nutrients such as protein, carbohydrate, B family vitamin, vitamin E, calcium, phosphorus, potassium, magnesium, iron, zinc, nutritious;
2) black rice has the free radical of removing, improves the different physiological roles such as hypoferric anemia, anti allergic reaction and immunological regulation;
3) the brass compounds in black rice can maintain the normal osmotic pressure of blood vessel, alleviates fragility of blood vessels, prevents angiorrhoxis and hemostasis;
4) black rice has antibacterially, reduces blood pressure, the effect of inhibition cancer cell growth;
5) inorganic salts such as the contained manganese of black rice, zinc, copper mostly than the high 1-3 of rice doubly; More contain the special composition such as vitamin C, chlorophyll, anthocyanidin, carrotene and cardiac glycoside that rice lacks, thereby black rice has more nutrition than general rice.Many food black rices have in appetizing benefit, strengthening spleen and warming liver, improving eyesight is invigorated blood circulation, the merit of sliding puckery benefits essence, for juvenile canities, women's puerperal asthenia, after being ill body void and anaemia, suffering from a deficiency of the kidney all has well tonic acting on.
Sorghum rice: sorghum rice is that Chinese sorghum grinds the graininess finished product of grain after peeling layer.Chinese sorghum taste is sweet, warm in nature, puckery, enters spleen, stomach warp; Have with stomach, long-pending, the temperature of disappearing in, puckery stomach, the effect of cholera only; Cure mainly the diseases such as water retention due to hypofunction of the spleen, indigestion and damp-heat diarrhea, difficult urination.
Oat: oat, has another name called bromegrass, wild wheat.Oat is generally divided into band bran type and the large class of naked grain type two.Be rich in the nutritional labelings such as starch, protein, fat, B family vitamin, niacin, folic acid, pantothenic acid, calcium, iron, there is the effects such as beneficial liver and stomach, beauty care.Oat can also antibacterium, oxidation resistant effect, can effectively increase the immunity of human body in spring, opposing influenza.
Heart of a lotus seed benevolence: heart of a lotus seed benevolence is the kind benevolence of grass Job's tears.The nutritive value of the seed of Job's tears is very high, is described as " king of world grass ".The seed of Job's tears can be used as grain and eats, and taste is similar with rice, and absorption easy to digest, cooks congee, does Tang Junke.Property sweet light, be slightly cold, nontoxic.Enter spleen, stomach, lung, large intestine.Clearing heat and promoting diuresis, except rheumatism, diuresis, beneficial lung apocenosis, strengthening the spleen and stomach, strengthening the bones and muscles.Cure mainly rheumatism bodily pain, hygropyretic beriberi, damp and hot muscular contracture contraction, arthritis with fixed pain caused by dampness, oedema, the lung lung carbuncle of withering, coughs vomiting of pus and blood, and larynx numbness carbuncle is swollen, and acute appendicitis heat is drenched.
Lactalbumin: lactalbumin is a kind of protein being present in nearly all mammal milk, is comprised of 123 amino acid residues, its amino acid sequence and stereochemical structure all with lysozyme homology, be a subunit of lactose synthase.Lactalbumin is called as the king of albumen, is a kind of protein extracting from milk, have to be of high nutritive value, absorption easy to digest, to contain the various active feature that becomes to grade, and be one of generally acknowledged human body good protein replenishers.The advantage of lactalbumin is as follows:
1,, in range protein, the nutritive value of lactalbumin is the highest.Generally speaking, essential amino acid kind and content protein complete and that can provide human body to need can be called good protein, is also complete protein.8 seed amino acids that it contains needed by human, and reasonable mixture ratio, approach the demand percentage of human body, is people's bulk-growth, growth, the indispensable elite material of the anti-ageing vital movement of waiting for a long time.
2, the easier digested absorption of lactalbumin, in breast milk, lactalbumin is containing 60%, and casein is containing 40%.In addition, be rich in cysteine and methionine in whey, they can maintain the level of antioxidant in human body.Also have many experimental studies all to prove, take whey protein concentrate and can promote humoral immunity and cellular immunity, stimulate human immune system, stop the generation of chemically induced property cancer.So lactalbumin is again a kind of albumen of extraordinary enhancing immunity.
3, fat in lactalbumin, lactose content is low, but it contains beta lactoglobulin, ALA, immunoglobulin (Ig), also has other various active compositions.These active components have possessed lactalbumin is just of value to many health cares of human body, so it is considered to one of good protein source of needed by human body.From the angle of nutrition, in the food in animal protein source, contain the harmful substances such as harmful excessive saturated fat, cholesterol, excessive edible body fat and the cholesterol of easily causing raises, thereby causes the generation of angiocardiopathy.By taking albumen powder, can when supplementing albumen, avoid these problems.
Chinese medicine extract:
The Chinese prescription of the Chinese medicine extract in food formula of the present invention, is on the basis of traditional recipe, through clinical testing, meticulously allocates and forms, and this prescription Chinese medicine used is respectively:
Radix Angelicae Sinensis: taste is sweet; Pungent; Bitter; Warm in nature.Return liver; The heart; The spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly all cards of the deficiency of blood; Irregular menstruation; Through closing; Dysmenorrhoea; Abdominal mass knot is poly-; Uterine bleeding; Asthenia cold abdominalgia; Impotence numbness; Numbness; Intestines are dry just difficult; Heavy after dysentery characterized by blood in the stool; Ulcer sores; Injury from falling down.
The fruit of glossy privet: taste is sweet, hardship, property is flat.Return liver; Kidney channel.Tonify the liver and kidney, strong waist knee, improve visual and auditory acuity, black beard and hair.
Rascal: bitter is pungent, warm in nature.Be included into liver, courage, stomach warp.Soothing the liver relieving stagnant Qi, long-pendingization that disappear are stagnant.For sternal rib gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.
The fruit of Chinese wolfberry: taste is sweet; Property is put down.Return Liver Channel; Kidney channel; Lung channel.Nourishing the liver; Nourshing kidney; Moistening lung.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness and weakness of waist and knees; Impotence and seminal emission; Cough due to consumptive disease; Quench one's thirst and draw drink.
Fructus Aurantii: bitter; Acid; Cold nature.Gui Jing: lung; Spleen; Liver; Stomach; Large intestine channel.Cure mainly: chest diaphragm ruffian is full; The distending pain in hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Abdominal fullness and distention; Heavy after diarrhea; Prolapse of the anus; The prolapse of uterus.
The seed of Chinese dodder: taste is sweet, warm in nature.Return liver,kidney,spleen warp.Nourishing liver and kidney, controlling nocturnal emission with astringent drugs contracting urine, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Poria cocos: property is sweet, light is flat.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Profit water medicine; Diuretics with the action of eliminating dampness.Cure mainly difficult urination; Oedema turgor; Phlegm and retained fluid is coughed contrary; Vomiting; Insufficiency of the spleen food is few; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission gonorrhoea.
Orange peel: the pungent and micro-hardship of taste, warm in nature, enter spleen, lung channel.In reasonable controlled atmosphere, eliminating dampness and eliminating phlegm effect, can be used for treating the taste stagnation of the circulation of vital energy, abdominal fullness and distention, and vomiting, or uncomfortable in chest due to turbi damp obstructing in middle-JIAO, indigestion and loss of appetite, loose stool, but YIN fluid deficiency, inside have real hot person to be cautious use of.
Rhizoma cyperi: pungent, sweet, the micro-hardship of taste, property is flat; Return liver, tri-jiao channel; The fragrant row of gas is loose, can rise and can fall.There is the Xie Yu of regulating the flow of vital energy, menstruction regulating and pain relieving.Cure mainly stagnation of QI due to depression of the liver, chest side of body ruffian is full, abdominal distention, and hernia pain, irregular menstruation, dysmenorrhea, amenorrhoea, under uterine bleeding band, fetal irritability.
Ligusticum wallichii: taste is pungent, warm in nature.Return liver, courage, pericardium channel.Promoting blood circulation; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Cure mainly headache; Irregular menstruation; Through closing dysmenorrhoea; The stagnant raw meat pain of the stasis of blood in postpartum; Abdominal mass lump; Pain in chest and hypochondrium; Have a headache dizzy; Wind-cold-dampness arthralgia; Traumatic injury; Ulcer sores.
Chinese herbaceous peony: bitter, property is flat, nontoxic.Scattered silt, invigorate blood circulation, the effect of pain relieving, purge the green, cure mainly the diseases such as irregular menstruation, the stagnant stomachache of phlegm, painful swelling of joints, pectoralgia, costalgia.
Valine: formal name used at school: 2-amino-3 Methylbutanoic acid is the nonpolar alpha amino acid of a kind of side chain that contains five carbon atoms.Valine is one of eight kinds of necessary amino acid of human body, and it is synthetic that available isobutylaldehyde is made raw material.For white crystals or crystalline powder, in water, dissolve, almost insoluble in ethanol.
When Valine is not enough, central nervous system in rat function can get muddled, incoordination and occur trembling of limbs.By anatomical slice brain tissue, find that there is rubrum cell degeneration phenomenon, end-age cirrhosis patient is because of hepatic disorder, easily form hyperinsulinemia, cause branched-chain amino acid in blood to reduce, the ratio of branched-chain amino acid and aromatic amino acid is down to 1.0-1.5 by normal person's 3.0-3.5, therefore the infringement that the injection for treating liver failure of the branched-chain amino acids such as conventional Valine and excessive drinking and drug abuse cause these organs.
L-Leu: formal name used at school: 2-amino-4-methylvaleric acid is a kind of nonpolar alpha amino acid of aliphatic side chain that contains 6 carbon atoms.L-Leu can be used as nutritional supplement; Seasoning fumet.Can prepare amino acid transfusion and comprehensive amino acid preparation, Hypoylycemic agents, plant growth promoter.L-Leu is repaired muscle with ILE cooperation together with Valine, controls blood sugar, and provides energy to bodily tissue.It also improves the output of growth hormone, and helps burning interior fat, and these fat are due in body interior, only by going on a diet and exercise is difficult to them to produce useful effect.
METHIONINE: being sulfur-bearing essential amino acid, is one of sulfur-bearing a-amino acid.Be a kind of composition of protein, a lot of in ovalbumin and casein, natural what obtain is L-type.METHIONINE can promote liver plasma membrane phospholipid methylation; make membrane fluidity strengthen Na+, K+-ATP enzyme pumping action is strong; can reduce the alluvial of bile in liver cell; turning sulfenyl effect strengthens; thereby strengthened the synthetic of the interior cysteine of liver cell, glutathione and taurine, reduced bile acid and built up in liver, strengthened detoxication; be conducive to liver cell and recover normal physiological function, impel jaundice to disappear and liver function recovery.The intrahepatic cholestasis virus infections that anti-a variety of causes causes, gestation and long-term parenteral alimentation all likely cause intrahepatic cholestasis; METHIONINE is by generating taurine and bile acid covalent bond; strengthen acid solubility; be easy to get rid of outside liver cell; simultaneously by the methylating of liver plasma membrane phosphorus, strengthen Na+, K+ ,-atpase activity promotes bile to arrange outward.Application METHIONINE can obviously reduce pruitus and the abnormal liver function being caused by cholestasis.
Steviol glycoside: be a kind of sucrose succedaneum, can not increase in the situation of heat, increase the sweet taste of food.
Compared with prior art, disclosed by the invention a kind of for the edible full nutrient formulation food of five cereals of hepatopath, there is following characteristics and significantly technological progress:
1, food provided by the present invention has met the specific demand of hepatopath to diet, when a large amount of high-quality protein is provided, strengthening Valine, L-Leu and METHIONINE, in the formula range through repetition test gained, these nutriments can act synergistically, and reach the effect of good nutrition and auxiliary curing.
2, food provided by the present invention has also added traditional Chinese medicine ingredients, through groping formula, traditional Chinese medicine ingredients and various nutrient is cooperatively interacted, and complements each other, and with micro-interpolation, brings adjuvant treatment effect significantly, specifically sees embodiment 8.
3, food provided by the present invention all has good adjuvant treatment effect to acute, chronic hepatitis, cirrhosis, liver ascites etc., is applicable to early stage hepatopath's auxiliary curing edible, also can be used as the potential risk person's of having a liver complaint daily health caring food.
The specific embodiment
The preparation of embodiment 1 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 220g, fruit of glossy privet 170g, rascal 80g, fruit of Chinese wolfberry 120g, Fructus Aurantii 120g, seed of Chinese dodder 100g, Poria cocos 220g, orange peel 120g, rhizoma cyperi 100g, Ligusticum wallichii 80g, Chinese herbaceous peony 100g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 20kg, sorghum rice 8kg, oat 10kg, heart of a lotus seed benevolence 8kg, PURE WHEY 8kg, Chinese medicine extract 15kg, Valine 0.008kg, L-Leu 0.02kg, METHIONINE 0.015kg, steviol glycoside 0.1kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The preparation of embodiment 2 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 270g, fruit of glossy privet 220g, rascal 120g, fruit of Chinese wolfberry 170g, Fructus Aurantii 170g, seed of Chinese dodder 150g, Poria cocos 270g, orange peel 170g, rhizoma cyperi 150g, Ligusticum wallichii 120g, Chinese herbaceous peony 150g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 25kg, sorghum rice 12kg, oat 15kg, heart of a lotus seed benevolence 12kg, PURE WHEY 12kg, Chinese medicine extract 20kg, Valine 0.012kg, L-Leu 0.04kg, METHIONINE 0.025kg, steviol glycoside 0.3kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The preparation of embodiment 3 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 260g, fruit of glossy privet 210g, rascal 110g, fruit of Chinese wolfberry 160g, Fructus Aurantii 160g, seed of Chinese dodder 140g, Poria cocos 260g, orange peel 160g, rhizoma cyperi 140g, Ligusticum wallichii 110g, Chinese herbaceous peony 140g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 24kg, sorghum rice 11kg, oat 14kg, heart of a lotus seed benevolence 11kg, PURE WHEY 11kg, Chinese medicine extract 19kg, Valine 0.011kg, L-Leu 0.03kg, METHIONINE 0.022kg, steviol glycoside 0.2kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The preparation of embodiment 4 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 230g, fruit of glossy privet 180g, rascal 90g, fruit of Chinese wolfberry 130g, Fructus Aurantii 130g, seed of Chinese dodder 110g, Poria cocos 230g, orange peel 130g, rhizoma cyperi 110g, Ligusticum wallichii 90g, Chinese herbaceous peony 110g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 21kg, sorghum rice 9kg, oat 11kg, heart of a lotus seed benevolence 9kg, PURE WHEY 9kg, Chinese medicine extract 16kg, Valine 0.009kg, L-Leu 0.03kg, METHIONINE 0.017kg, steviol glycoside 0.2kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The preparation of embodiment 5 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 240g, fruit of glossy privet 180g, rascal 110g, fruit of Chinese wolfberry 130g, Fructus Aurantii 160g, seed of Chinese dodder 110g, Poria cocos 250g, orange peel 130g, rhizoma cyperi 140g, Ligusticum wallichii 90g, Chinese herbaceous peony 140g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 24kg, sorghum rice 9kg, oat 14kg, heart of a lotus seed benevolence 9kg, PURE WHEY 11kg, Chinese medicine extract 17kg, Valine 0.009kg, L-Leu 0.02kg, METHIONINE 0.019kg, steviol glycoside 0.2kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The preparation of embodiment 6 nutrient powder of the present invention:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take each taste Chinese medicine above: Radix Angelicae Sinensis 250g, fruit of glossy privet 200g, rascal 100g, fruit of Chinese wolfberry 150g, Fructus Aurantii 150g, seed of Chinese dodder 120g, Poria cocos 250g, orange peel 150g, rhizoma cyperi 120g, Ligusticum wallichii 100g, Chinese herbaceous peony 120g, pulverize respectively, mix, the purified water that adds 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) by filling a prescription and accurately take above: black rice 22kg, sorghum rice 10kg, oat 13kg, heart of a lotus seed benevolence 10kg, PURE WHEY 10kg, Chinese medicine extract 18kg, Valine 0.01kg, L-Leu 0.03kg, METHIONINE 0.02kg, steviol glycoside 0.2kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
Embodiment 7 does not add the preparation of the nutrient powder of the present invention of Chinese medicine extract:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) by filling a prescription and accurately take above: black rice 22kg, sorghum rice 10kg, oat 13kg, heart of a lotus seed benevolence 10kg, PURE WHEY 10kg, Valine 0.01kg, L-Leu 0.03kg, METHIONINE 0.02kg, steviol glycoside 0.2kg, add purified water, be mixed into scattered paste shape, be heated to 100 ℃, keep 5 minutes, be cooled to room temperature;
3) by 2) oven dry of gained pastel, pulverize, cross 80 mesh sieves, with 40g/ bag packing, be finished product.
The present embodiment products obtained therefrom is only for clinical testing.
The clinical testing of embodiment 8 nutrient powder of the present invention
Clinical testing is divided into three parts, and first is acute and chronic toxicity test; Second portion is the impact experiment of the hepatic fibrosis hyperplasia degree of rat; Third part is clinical effectiveness experiment.
(1) the slow toxicity test of the urgency of animal:
Preliminary experiment shows, nutrient powder of the present invention, and toxicity is very little, cannot measure LD
50, therefore, according to maximum dosage feeding.
1, animal acute toxicity test
Medicine: the embodiment of the present invention 6 and embodiment 7 gained nutrient powder.
Experimental animal: regular grade NIH mouse, body weight 18g ± 2g, male and female half and half.
Method and result:
1) by two kinds of each 40g of nutrient powder, by 160ml warm water, be modulated into pasty state respectively.
2) experiment mice is divided at random to two groups of male and female half and half, two kinds of nutrient powder of feeding are stuck with paste respectively, volume 2ml/10g body weight, and close observation 8h also notes down, and continues to observe 7 days;
3) in 7 days, mouse is without death, and behavior is active, and food ration is as usual, and hair color light, without loose dirty, is had a liking for saliva without fainting from fear, and eye, mouth, nose, ear and crissum are without abnormal secretion, without the rotten toe of docking.From two groups, select respectively 10 execution, finding of naked eye: in the heart, liver, lung, stomach and the important organ such as thymus gland, no abnormality seen changes, and shows that two kinds of these nutrient powder are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 6 and embodiment 7 gained nutrient powder.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
1) configuration of two kinds of nutrient powder: be divided into high, medium and low three dosage groups, be respectively 240,120,60 times of edible for patients amount, be mixed into pasty state with warm water 1:1 respectively;
2) experimental mouse is divided into two groups at random, the nutrition that feeding modulates continuously is respectively stuck with paste, feeding is 60 days continuously, observe animal general toxic reaction and the order of severity, after execution, by operational procedure, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach;
3) through long-term feeding, all there is not toxic reaction in two groups of rats.Physically well develop.Naked eyes outward appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN and control group relatively change without pathologic.All not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, and two kinds of nutrition are stuck with paste animal is showed without chronic toxicity.
By above two toxicity tests, prove that the nutrient powder that the present invention makes by embodiment 6 and embodiment 7 is safe, have no side effect, can be used for clinical patients to carry out clinical testing.
(2) impact of nutrient powder of the present invention on the hepatic fibrosis hyperplasia degree of hepatic fibrosis rats
When liver suffers various pathogenic former invasion and attack, cause liver damage and inflammatory reaction, hepatic tissue immune system is activated simultaneously, carries out tissue repair.Liver fibrosis refers to this process of tissue reparation, excessive and when out of control, a kind of pathologic process that liver structure and dysfunction of liver change due to hepatic tissue inner cell epimatrix hyperplasia and abnormal deposition.
1, modeling
Get 84 of SPF level Wistar rats, body weight 200g ± 10g, male and female half and half, check all rats before experiment, look into after abnormal and get 72, first the pure CCl of rat skin lower injection
4, dosage 5ml/kg changes hypodermic injection CCl into later
440% peanut oil solution, dosage 3ml/kg, every 3 days 1 time, totally 6 weeks.The normal solid feed of feeding, freely drinks water.
2, test method
After Cheng Mo, rat is divided into model control group, colchicin group, 1 group of embodiment, 2 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, totally 6 groups, 12 every group, male and female half and half at random.
The method of each treated animal medication and feeding is as shown in table 1:
The dosage method of each treated animal medication of table 1 and feeding
Each organizes after last administration fasting 12 hours, weighs, and through yellow Jackets intraperitoneal injection of anesthesia, gets Rat Right leaflet liver, approximately 0.5 centimetre of thickness hepatic tissue of clip, and neutral formalin buffer solution is fixed, FFPE, section is 5 μ m thickness.Through multistage dehydration of alcohol, dimethylbenzene is transparent, does HE dyeing, and sirius red dyeing, takes pathological tissue photo under light microscopic, observe the situation of change of proliferation of fibrous tissue degree.
3, experimental result
After observing pathological section, find:
1) blank group: in liver tissues of rats, lobuli hepatis clear in structure is complete, hepatic cell cords marshalling, downright bad without liver cell lesion, without cell infiltration, without fibroplasia.
2) model control group: the visible liver cell arrangement disorder of liver tissues of rats, the sex change of liver cell cavity sample, necrosis, the a large amount of proliferations of fibrous tissue in portal area are also dispersed in inflammatory cell infiltration, and the visible proliferation of fibrous tissue of most of rat extends to lobuli hepatis, separate lobuli hepatis and form pseudolobuli.
3) colchicin group: rat hepatocytes degeneration necrosis alleviates, the visible pseudolobuli of part rat.
4) embodiment is 1 group: rat hepatocytes degeneration necrosis alleviates, lighter than colchicin group, the visible pseudolobuli of part rat.
5) embodiment is 2 groups: rat hepatocytes degeneration necrosis alleviates, lighter than colchicin group, and 1 group of embodiment is approaching, the visible pseudolobuli of part rat.
6) embodiment is 6 groups: rat hepatocytes degeneration necrosis significantly alleviates, gently more a lot of than colchicin group, is best in all groups, the visible pseudolobuli of small part rat.
7) embodiment is 7 groups: rat hepatocytes degeneration necrosis alleviates, lighter than colchicin group, but the poorest in four embodiment groups, the visible pseudolobuli of part rat.
The proliferation of fibrous tissue situation of observing under light microscopic is showed with symbol, "++++ " for the most serious, "
-" be without fibroplasia.Result is as shown in table 2:
Table 2 Ge Zu rat tissue collagenous fibres hyperplasia degree classification comparable situation (n=10)
*p<0.01，
$p<0.01，
#p<0.01。
Normal rats hepatic tissue section shows that model group fibroplasia is obvious without liver fibrosis formation, and model modeling success is described.Four nutrient powder groups and colchicin group all have clear improvement to hepatic fibrosis rats, and wherein 6 groups of improvement of embodiment are the most obvious, and 1,2 groups of embodiment take second place, and 7 groups the poorest of embodiment than colchicin group more by force.
4, interpretation of result
The pathology results of this experiment shows, nutrient powder of the present invention is used together with medicine, medicine is had to good synergy, and when not adding traditional Chinese medicine ingredients, still there is good booster action, after having added micro-traditional Chinese medicine ingredients, effect highly significant, illustrate in formula of the present invention traditional Chinese medicine ingredients can and the amino acid of nutrient, strengthening complement each other, there is mutual collaborative pharmacological action, occurred beat all technique effect.
(3) clinical observation of nutrient powder of the present invention is as follows:
1, experimental subjects:
Patient's 180 examples, the male sex's 101 examples wherein, women's 79 examples, the age is 20-50 years old 76 example, 50 years old above 104 example.
2, diagnostic criteria:
Feel sick, abdominal distension, weak, pain in the hepatic region, hepatomegaly, ascites.
3, methods for the treatment of:
Patient is divided into 5 groups at random, every group of 36 people, in sex, there is comparativity age, aetology and state of an illness weight aspect.Adopt composite treatment, every group all protects the liver, falls liquid and the oral drug therapies such as enzyme, removing toxic substances routinely, as Potassium Magnesium Aspartate, glutathione etc.Selecting at random one group is placebo, and all the other four groups are except complex treatment, and every group eats respectively embodiment 1,2,6,7 prepared nutrient powder, each 40g, every day three times, 5 hours, interval; Placebo, except complex treatment, is taken placebo (a kind of starch without any therapeutic action) dose identical with all the other four groups.Take continuously 30 days.
4, efficacy assessment standard:
Cure: feel sick, abdominal distension, weak transference cure, hepatic region is without tenderness; Liver recovers normally or obviously bounces back, and below SGPT 40 units, HBsAg turns out cloudy.
Take a turn for the better: idol has nauseating, abdominal distension, weak symptom, hepatic region tenderness, button pain alleviate; Liver recovers normal or retraction, and ascites alleviates.
Invalid: feel sick, abdominal distension, weak, pain in the hepatic region, hepatomegaly, ascites phenomenon is without improvement.
5, treatment results is in Table 3
Table 3 hepatopath takes the effect of nutrient powder of the present invention
6, interpretation of result: as can be seen from Table 3, nutrient powder of the present invention is compared the effect that has obvious auxiliary curing with placebo; 7 groups of effects of embodiment of not adding traditional Chinese medicine ingredients are the poorest, 6 groups of effects of optimization formula embodiment are best, this has confirmed the result of clinical trial (two) above again: in formula of the present invention, the amino acid of traditional Chinese medicine ingredients energy and nutrient, strengthening complements each other, there is mutual collaborative pharmacological action, occurred beat all technique effect.
Claims (6)
1. one kind supplies the edible full nutrient formulation food of five cereals of hepatopath, it is characterized in that: described food is made by black rice, sorghum rice, oat, heart of a lotus seed benevolence, PURE WHEY, Chinese medicine extract, L-valine, L-leucine, L-methionine, steviol glycoside hybrid process, wherein:
(1) proportioning of the various raw materials of described food is: black rice 20-25 weight portion, sorghum rice 8-12 weight portion, oat 10-15 weight portion, heart of a lotus seed benevolence 8-12 weight portion, PURE WHEY 8-12 weight portion, Chinese medicine extract 15-20 weight portion, L-valine 0.008-0.012 weight portion, L-leucine 0.02-0.04 weight portion, L-methionine 0.015-0.025 weight portion, steviol glycoside 0.1-0.3 weight portion;
(2) Chinese prescription of described Chinese medicine extract is: Radix Angelicae Sinensis 22-27 weight portion, fruit of glossy privet 17-22 weight portion, rascal 8-12 weight portion, fruit of Chinese wolfberry 12-17 weight portion, Fructus Aurantii 12-17 weight portion, seed of Chinese dodder 10-15 weight portion, Poria cocos 22-27 weight portion, orange peel 12-17 weight portion, rhizoma cyperi 10-15 weight portion, Ligusticum wallichii 8-12 weight portion, Chinese herbaceous peony 10-15 weight portion.
2. as claimed in claim 1 a kind of for the edible full nutrient formulation food of five cereals of hepatopath, it is characterized in that: the proportioning of the various raw materials of described food is: black rice 22 weight portions, sorghum rice 10 weight portions, oat 13 weight portions, heart of a lotus seed benevolence 10 weight portions, PURE WHEY 10 weight portions, Chinese medicine extract 18 weight portions, L-valine 0.03 weight portion, L-leucine 0.01 weight portion, L-methionine 0.02 weight portion, steviol glycoside 0.2 weight portion.
3. a kind of edible full nutrient formulation food of five cereals of hepatopath that supplies as described in claim 1, is characterized in that: the Chinese prescription of described Chinese medicine extract is: Radix Angelicae Sinensis 25 weight portions, the fruit of glossy privet 20 weight portions, rascal 10 weight portions, the fruit of Chinese wolfberry 15 weight portions, Fructus Aurantii 15 weight portions, the seed of Chinese dodder 12 weight portions, Poria cocos 25 weight portions, orange peel 15 weight portions, rhizoma cyperi 12 weight portions, Ligusticum wallichii 10 weight portions, Chinese herbaceous peony 12 weight portions.
4. a kind of for the hepatopath edible full nutrient formulation food of five cereals as described in claim 1, is characterized in that the preparation technology of described food is:
1) fine gtinding is cleaned, dried to black rice, sorghum rice, oat, heart of a lotus seed benevolence, cross 100 mesh sieves, standby;
2) accurately take each taste Chinese medicine: Radix Angelicae Sinensis, the fruit of glossy privet, rascal, the fruit of Chinese wolfberry, Fructus Aurantii, the seed of Chinese dodder, Poria cocos, orange peel, rhizoma cyperi, Ligusticum wallichii, Chinese herbaceous peony, pulverize respectively, mix, add the purified water of 7 times of weight, reflux and decoct 1 hour, a filters to get filtrate; The water that adds 5 times of weight in filter residue, then the decoction 1 hour that refluxes, the b that filters to get filtrate, mixes a and b, is Chinese medicine extract, standby;
3) accurately take: black rice flour, Chinese sorghum ground rice, oatmeal, lotus-seed-heart powder, lactalbumin
Powder, Chinese medicine extract, L-valine, L-leucine, L-methionine, steviol glycoside, add purified water, is mixed into scattered paste shape, is heated to 100 ℃, keeps 5 minutes, is cooled to room temperature;
4) by 3) oven dry of gained pastel, pulverize and make finished product.
5. a kind of edible full nutrient formulation food of five cereals of hepatopath that supplies as described in claim 1, is characterized in that: described food is made powdery, graininess or block food.
6. a kind of edible full nutrient formulation food of five cereals of hepatopath that supplies as described in claim 1, is characterized in that: as the health nutrient of prevention of liver disease.
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| CN103892276A (en) * | 2013-12-23 | 2014-07-02 | 刘云龙 | Health-care coarse cereal powder and preparation method thereof |
| CN103859419B (en) * | 2014-03-20 | 2015-01-14 | 安徽华禹食品有限公司 | Vitamins-containing blood-replenishing protein powder suitable for valetudinarians and preparation method of protein powder |
| CN104920963A (en) * | 2015-06-18 | 2015-09-23 | 恩施土家族苗族自治州农业科学院 | Selenium-rich liver-protecting food |
| JP2017101002A (en) * | 2015-12-04 | 2017-06-08 | イーエヌ大塚製薬株式会社 | Nutritional composition for improving ascites retention |
| CN106617020A (en) * | 2016-09-12 | 2017-05-10 | 惠安县科联农业科技有限公司 | Special food formula for patients with hepatopathy and preparation method of food formula |
| CN106616374A (en) * | 2016-12-02 | 2017-05-10 | 芜湖市诺康生物科技有限公司 | Nutrition formula food for patient with liver cirrhosis to eat |
| CN108552529A (en) * | 2018-04-29 | 2018-09-21 | 广东伊茗药业有限公司 | A kind of full nutrition formula food suitable for hepatopath |
| CN112754007A (en) * | 2021-01-25 | 2021-05-07 | 胡其勇 | Coarse grain powder with hepatitis B treatment function and preparation method thereof |
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