CN103394009B - Traditional Chinese medicine for treating trauma and diabetes foot ulcer and preparation method - Google Patents
Traditional Chinese medicine for treating trauma and diabetes foot ulcer and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating trauma and diabetes foot ulcer and a preparation method. The medicine comprises the following raw materials in parts by mass: 1-2.5 parts of rhizoma paridis, 0.8-1.5 parts of rhizoma paridis, 0.5-1 part of rhizoma arisaematis, 0.5-2 parts of rhizoma kaempferiae, and 0.5-1 part of lithospermum. The preparation method comprises the following steps of mixing the raw materials and then grinding to 100-180 meshes, and sterilizing to obtain powder. The medicine has the functions of promoting and adjusting the circulation of qi and blood of the meridian, fighting against bacterium and diminishing inflammation, stopping bleeding and dissipating blood stasis, promoting qi and relieving pain, and clearing away heat and toxic materials, is dramatic in the effect of regenerating tissue to heal wound, rapid in wound healing, and wide in adaptation diseases, and is especially applicable to the treatment of diabetes foot ulcer, with little acne signs or scars left.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of wound and bran urine foot disease ulcer, also relate to the preparation method of this medicine, belong to Chinese medicine technical field.
Background technology
China Patent Publication No.: CN102688368A; Open day: on 09 26th, 2012; Denomination of invention < < Chinese medicine > > who treats trauma hemostasis and intractable ulcer, by the ingredients of following weight portion: Scolopendra 50-55 part, Cortex Moutan charcoal 30-35 part, Rhizoma Paridis 3-5 part, Radix Notoginseng 3-5 part, Herba Cirsii 3-5 part, Gypsum Fibrosum Preparatum 3-5 part.In drug matching, further clear and definite Scolopendra is in " monarch drug " and the status of Cortex Moutan charcoal " ministerial drug " of joining in main, the formulation principle that meets monarch, have that hemostasis, detumescence relieve the pain, the effect of blood stasis dispelling, hard masses softening and resolving, be used for the treatment of intractable ulcer, large-area burns and hemostasis.This technical scheme relatively payes attention to the detumescence of ulcer wound surface to relieve the pain, and hard masses softening and resolving and removing pyretic toxicity, but ignored the promoting the circulation of QI to relieve pain of whole body of human body meridians and the endogenous wind stopping relieving convulsion on meridians, and expelling wind for relieving convulsion is poor to the conditioning effect of Whole Body; At removing heat from blood, invigorate blood circulation, anti-inflammation, removing toxic substances rash and the metabolism that accelerates pox seal and cicatrix, promoting tissue regeneration and ulcer healing, makes the rear preventing from scar of wound surface, and cosmetology aspect, particularly to also perfect not to the utmost on the immunotherapy targeted autoantibody of diabetic foot ulcer.
Summary of the invention
The object of the invention is to pay attention to for prior art the reparation of local lesion, and the QI and blood of ignoring human body is nursed one's health and defect and the deficiency of strengthening body resistance and dispelling evil, a kind of Chinese medicine and preparation method for the treatment of wound and bran urine foot disease ulcer proposed, described Chinese medicine can promote QI-blood circulation and the conditioning of collaterals of human, anti-inflammation, hemostasis dissipating blood stasis, circulation of qi promoting analgesia, heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing successful, wound healing is fast, pox seal and cicatrix are few, indication is extensive, be particularly suitable for the immunotherapy targeted autoantibody to diabetic foot ulcer, described method is simple, easy to operate, production cost is lower.
The object of the present invention is achieved like this, a kind of Chinese medicine for the treatment of wound and bran urine foot disease ulcer, and the raw material of described Chinese medicine forms and mass parts ratio is: RHIZOMA BISTORTAE 1～2.5; Rhizoma Paridis 0.8～1.5; Rhizoma Arisaematis (processed) 0.5～1; Rhizoma Kaempferiae 0.5～2; Radix Arnebiae (Radix Lithospermi) 0.5～1.
The raw material of described Chinese medicine forms and mass parts ratio is: RHIZOMA BISTORTAE 2; Rhizoma Paridis 1; Rhizoma Arisaematis (processed) 1; Rhizoma Kaempferiae 2; Radix Arnebiae (Radix Lithospermi) 0.5.
The preparation method of Chinese medicine of the present invention is to take RHIZOMA BISTORTAE in mass parts ratio, Rhizoma Paridis, and Rhizoma Arisaematis (processed), Rhizoma Kaempferiae and Radix Arnebiae (Radix Lithospermi), be crushed to 100～180 orders after being mixed, and sterilizing, obtains powder.
By described powder water or edible oil furnishing pasty state, obtain unguentum,
Described water is normal saline, and the mass ratio of described powder and normal saline is 40:60～60:40.
Described oil is Oleum sesami or Adeps Sus domestica, and the mass ratio of described powder and Oleum sesami is 45:55～55:45, and the mass ratio of described powder and Adeps Sus domestica is 35:65～55:45.
In Chinese medicine of the present invention
RHIZOMA BISTORTAE has another name called Rhizoma Paridis.Bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing.The diseases such as treatment of ulcer carbuncle furuncle, hygropyretic dysentery.There are hemostasis and antibacterial action.
Rhizoma Paridis is that Liliales Trilliaceae plant has another name called Rhizoma Paridis, is the rhizome of Rhizoma Paridis, is heat and toxic materials clearing away medicine, and hardship, is slightly cold.Slightly poisonous, GUIXIN, lung, Liver Channel.Have the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, hemostasis, treatment traumatic injury has unique curative effect.For the high heat of epidemic febrile disease, convulsion with spasms, or excessive noxious heat, laryngopharynx swelling and pain.Also can be used for hot carbuncle toxin, scrofula, venom.Discovered in recent years Rhizoma Paridis and chemical composition thereof have good antibacterial action, antiinflammatory action, anti-ulcer effect, antitumor action, Cardiovascular, sedation and analgesia effect, function of relieving cough and calming asthma and press down the physiologically actives such as essence effect.
Rhizoma Arisaematis (processed), have another name called Rhizoma Arisaematis, Jiang Nan magnitude.This product pungent drugs can disperse and bitter drugs can purge, warm-dryness syndrome reduces phlegm, and both except meridians wind-phlegm, except taste damp-phlegm, is longer than endogenous wind stopping relieving convulsion again, is suitable for all cards of wind-phlegm and pertinacious phlegm cough with asthma, is the strong product of warm-dryness syndrome.There is drying dampness to eliminate phlegm, expelling wind for relieving convulsion, the effect of dispersing swelling and dissipating binds.Cure mainly middle wind-phlegm and stop up, deviation of the eye and mouth, hemiplegia, epilepsy, infantile convulsion, tetanus, dizziness due to wind-phlegm, sore throat, scrofula, carbuncle furuncle, falls and flutters injured, snake bite and insect sting.
Rhizoma Kaempferiae is again Rhizoma Kaempferiae, nature and flavor: pungent, and temperature.Return stomach warp.Warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain.There is circulation of qi promoting warming middle-JIAO, help digestion, the effect of pain relieving.Cure mainly acute gastroenteritis, dyspepsia, septum pectorale distension, coldness and pain in the epigastrium, diet does not disappear.Cold syndrome of the stomach pain, toothache, rheumatic arthritis, traumatic injury.Radix Arnebiae (Radix Lithospermi) claim again Zi Dan, purple Yao, blood etc., cure mainly: removing heat from blood, invigorate blood circulation, removing toxic substances rash.For heat in blood poison contain, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Because Radix Arnebiae (Radix Lithospermi) major function is removing heat from blood, blood circulation promoting and blood stasis dispelling, removing toxic substances rash, therefore can accelerate the metabolism of pox seal and cicatrix, add the bactericidal antiphlogistic effect that it is good, Radix Arnebiae (Radix Lithospermi) has the effect of significant anti-acne and antiinflammatory, has very large its cosmetic values, and the lithosperman in Radix Arnebiae (Radix Lithospermi) also has hypoglycemic effect simultaneously.Chinese medicine of the present invention be take RHIZOMA BISTORTAE as monarch drug, Rhizoma Paridis, Radix Arnebiae (Radix Lithospermi) are ministerial drug, take Rhizoma Arisaematis (processed) as corrigent, with Rhizoma Kaempferiae for making medicine, all medicine synergism, the meridian qi and blood that makes Chinese medicine of the present invention act on patient's human body by wound surface moves, thereby trace back this by mark, reach this positive source clearly, the effect for the treatment of both the principal and secondary aspects of a disease, to various wounds, as bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury all have the curative effect of good anti-inflammation, hemostasis dissipating blood stasis, circulation of qi promoting analgesia, heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing and cosmetology.
Particularly the present invention is directed to diabetics immunologic function degression, resistance reduces, easily infect and occur that skin scabies is swollen, breathe, the various inflammation such as urinary system biliary system, and sensory nerve obstacle causes extremity tip position paresthesia of skin, as formication, numb, prickling sensation, the symptoms such as pruritus, in conjunction with its cause of disease master at lung, stomach, kidney, basic pathogenesis is cloudy body fluid deficiency consumption, the principle of scorching inclined to one side Sheng, by acting on the heart, lung, the RHIZOMA BISTORTAE of Liver Channel, Rhizoma Paridis, Radix Arnebiae (Radix Lithospermi) dredging collateral is invigorated blood circulation, reduce blood glucose, bactericidal antiphlogistic, removing pathogenic heat from blood and toxic substance from the body, improve patient's self resistance and immunocompetence, improve the microcirculation situation of ulcer spot, by acting on Rhizoma Kaempferiae and the Rhizoma Arisaematis (processed) circulation of qi promoting of stomach warp, ease pain, hemostasis dissipating blood stasis, promoting tissue regeneration and ulcer healing, accelerate reparation and the healing of ulcer spot, diabetic foot ulcer disease is had to good therapeutic effect.
beneficial effect of the present invention:
1. medicine material compatibility of the present invention is reasonable, and composition is simple, and indication is in extensive range, to the various outer hemorrhagic wounds that injure, as to insect-animal injury, skin infection, carbuncle furuncle, burn, cold injury therapeutic effect is obvious, wound healing is fast, and wound healing is effective, reduces softening cicatrix, beautifying skin effect.
2. medicine of the present invention is based on the conditioning of Whole Body, bactericidal antiphlogistic, blood circulation promoting and blood stasis dispelling, dispelling toxicity, detoxicating, circulation of qi promoting analgesic effect is obvious, better to the conditioning effect of Whole Body, be conducive to improve the resistance of human body self, immunity and anti-tumor capacity, and accelerate the healing of wound surface.
3. medicine of the present invention can improve the microcirculation situation of ulcer spot, bactericidal antiphlogistic, promoting tissue regeneration and ulcer healing successful, particularly the Radix Arnebiae (Radix Lithospermi) in medicine of the present invention has certain hypoglycemic activity, can accelerate reparation and the healing of ulcer spot, diabetic foot ulcer disease is had to good therapeutic effect.
4. the present invention can reduce wound exudate, and convergence, analgesia, have good therapeutic effect to rheumatic arthritis arthralgia.
Chinese medicine of the present invention is treated totally 305 examples through Hospital Attached to Hubei Chinese Medicine College's clinical experiment.Wherein relate to cutter, rifle is hemorrhage and traumatic injury 58 examples, burn 66 examples (burn example, scald example), cold injury 41 examples, insect-animal injury 30 examples (redness that unknown insect bite causes and skin infection 12 examples, pet cat, Canis familiaris L. sting, scratch 18 examples), skin infection, carbuncle furuncle 61 examples, diabetic foot ulcer 49 examples, its therapeutic effect refers to table one.
Various wounds in table one, the curative effect determinate standard of skin infection, carbuncle furuncle and diabetic foot ulcer is:
1. recovery from illness: General Symptoms disappears, local swelling is dissipated, or pus absorption dissipation, or skin ulcer face healing after bursting, and blood leukocytes is normally total.
2. effective: General Symptoms disappears, and swelling, abscess or the open sore part have been dwindled more than 70%, blood leukocytes sum is normal.
3. effective: General Symptoms alleviates, swelling, abscess or the open sore part have been dwindled more than 30%, and below 70%, blood leukocytes sum approaches normal.
4. invalid: not reach effective standard.
Table one
Note: 32 routine traumatic hemorrhage, 28 routine burns (burn 4 examples in table one, scald 14 examples), 37 routine cold injury, 23 routine insect-animal injurys (redness that unknown insect bite causes and skin infection 15 examples, pet cat, Canis familiaris L. 8 examples of stinging, scratch), 27 routine skin infection, carbuncle furuncle, 14 routine diabetic foot ulcer patients' wound surface more after without cicatrix.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is described in further detail.
embodiment 1:
By 1 kilogram of dry product raw material RHIZOMA BISTORTAE; 0.8 kilogram of Rhizoma Paridis; 0.5 kilogram of Rhizoma Arisaematis (processed); After 0.5 kilogram of Rhizoma Kaempferiae and 0.5 kilogram of mixing of Radix Arnebiae (Radix Lithospermi), be crushed to 100 orders, drying and sterilizing at 80 ℃ of temperature, obtains powder of the present invention.
Also can by described powder and normal saline in mass ratio routine 40:60 be modulated into pasty state unguentum.Also can by described powder and Oleum sesami in mass ratio routine 45:55 be modulated into pasty state unguentum, or by described powder and Adeps Sus domestica in mass ratio routine 35:65 be modulated into pasty state unguentum.By its powder water or edible oil furnishing pasty state, obtain unguentum.
Powder available water of the present invention or edible oil furnishing pasty state, obtain unguentum.Described water is distilled water or pure water, preferably medical saline.Described edible oil is Oleum Arachidis hypogaeae semen, Oleum Brassicae campestris, olive oil, fish oil, Adeps Bovis seu Bubali, Adeps Caprae seu ovis etc., but preferably Oleum sesami and Adeps Sus domestica.While being in harmonious proportion with Adeps Sus domestica and powder, can first Adeps Sus domestica be dissolved, then with powder furnishing pasty state, after Adeps Sus domestica is cooling harder cream piece, during use, cream piece is cut into lamellar and spreads on affected part, or gauze is wrapped up again.
embodiment 2:
By 2 kilograms of dry product raw material RHIZOMA BISTORTAEs; 1 kilogram of Rhizoma Paridis; 1 kilogram of Rhizoma Arisaematis (processed); After 1 kilogram of Rhizoma Kaempferiae and 0.5 kilogram of mixing of Radix Arnebiae (Radix Lithospermi), be crushed to 150 orders, adopt 90 ℃ of high temperature sterilizes, obtain Chinese powder medicine of the present invention.Also can by described powder and normal saline in mass ratio routine 60:40 be modulated into pasty state unguentum, also can by described powder and Oleum sesami in mass ratio routine 55:45 be modulated into pasty state unguentum, or by described powder and Adeps Sus domestica in mass ratio routine 65:35 be modulated into pasty state unguentum.
embodiment 3:
By 2.5 kilograms of dry product raw material RHIZOMA BISTORTAEs; 1.5 kilograms of Rhizoma Paridis; 1 kilogram of Rhizoma Arisaematis (processed); 1 kilogram of 2 kilograms of Rhizoma Kaempferiaes and Radix Arnebiae (Radix Lithospermi).After mixing, be crushed to 180 orders, adopt ultraviolet disinfection, obtain Chinese powder medicine of the present invention.Also can by described powder and normal saline in mass ratio routine 50:50 be modulated into pasty state unguentum, also can by described powder and Oleum sesami in mass ratio routine 50:50 be modulated into pasty state unguentum.Also powder that can be described and Adeps Sus domestica in mass ratio routine 65:35 are modulated into pasty state unguentum, or by described powder and Adeps Sus domestica in mass ratio routine 50:50 be modulated into pasty state unguentum.
embodiment 4:
By 1.5 kilograms of raw material RHIZOMA BISTORTAEs; 0.9 kilogram of Rhizoma Paridis; 0.9 kilogram of Rhizoma Arisaematis (processed); After 1.5 kilograms of Rhizoma Kaempferiaes and 0.8 kilogram of mixing of Radix Arnebiae (Radix Lithospermi), be crushed to 160 orders, adopt ultraviolet disinfection, obtain Chinese powder medicine of the present invention.Also can by described powder and normal saline in mass ratio routine 58:42 be modulated into pasty state unguentum, also can by described powder and Oleum Arachidis hypogaeae semen in mass ratio routine 54:46 be modulated into pasty state unguentum, or by described powder and Adeps Sus domestica in mass ratio routine 45:55 be modulated into pasty state unguentum.
embodiment 5:
By 1 kilogram of raw material RHIZOMA BISTORTAE; 1.2 kilograms of Rhizoma Paridis; 0.8 kilogram of Rhizoma Arisaematis (processed); After 1.5 kilograms of Rhizoma Kaempferiaes and 0.8 kilogram of mixing of Radix Arnebiae (Radix Lithospermi), be crushed to 140 orders, adopt microwave sterilizating, obtain Chinese powder medicine of the present invention.Also can by described powder and distilled water in mass ratio routine 58:42 be modulated into pasty state unguentum, also can by described powder and Oleum sesami in mass ratio routine 54:46 be modulated into pasty state unguentum, or by described powder and fish oil in mass ratio routine 55:45 be modulated into pasty state unguentum.
embodiment 6:
By 1.2 kilograms of dry product raw material RHIZOMA BISTORTAEs; 0.9 kilogram of Rhizoma Paridis; 0.6 kilogram of Rhizoma Arisaematis (processed); After 1.8 kilograms of Rhizoma Kaempferiaes and 0.6 kilogram of mixing of Radix Arnebiae (Radix Lithospermi), be crushed to 120 orders, adopt microwave sterilizating, obtain Chinese powder medicine of the present invention.Also can by described powder and 0.5% normal saline in mass ratio routine 43:57 be modulated into pasty state unguentum, also can by described powder and Oleum sesami in mass ratio routine 58:42 be modulated into pasty state unguentum, or by described powder and Adeps Sus domestica in mass ratio routine 60:40 be modulated into pasty state unguentum.
Described powder and unguentum can directly spread, are coated with or spread on affected part, or again with gauze wrapping, within 1st, change dressings one to twice.For hemorrhage wound and insect-animal injury, a course for the treatment of, can fully recover.General minor cut or wound seven days is a course for the treatment of, and large wound fortnight is a course for the treatment of.For scalding, burn and cold injury, skin infection, carbuncle furuncle, can fully recover one or two course for the treatment of.General little wound surface seven days is a course for the treatment of, and large wound surface seven days is a course for the treatment of.
For diabetic foot ulcer treatment cycle, be about two courses for the treatment of, fortnight is a course for the treatment of.
Concrete case
Week * *, female, 74 years old, skin infection, intractable ulcer patient, two more than ten years of two varicose veins of the lower extremity, left lower extremity ulcer 6 wheat harvesting periods, part presents swollen, hard tuberosity, increases gradually, has risen root bundle, skin ulcer color is red, and there are purulent core, a plurality of pus heads in skin ulcer top, pain is obvious, tenderness, blood leukocytes sum and neutrophilic granulocyte number increase, blood leukocytes sum 1.5 ╳ 10
9/ l, neutrophilic granulocyte number 75%, seeks medical advice everywhere, and treatment substantially to no effect, has hospital's suggestion amputation.Rear employing treatment by Chinese herbs of the present invention, spreads powder of the present invention to ulcer surface after cleaning once a day wound surface, then with gauze wrapping, medication is after 7 days, and redness obviously alleviates, and ulcer surface dwindles, and blood leukocytes sum is down to 0.9 ╳ 10
9/ l, neutrophilic granulocyte number 62%, continues medication to the 14 days, and left lower extremity is without red, swollen, and without pain, ulcer wound surface heals, and blood leukocytes sum is down to 0.7 ╳ 10
9/ l, neutrophilic granulocyte number 50%, does not stay obvious cicatrix, treatment recovery from illness.
Liu * *, female, 31 years old, right thumb cutter incised wound, long 4 centimetres of wound, dark 0.5 centimetre, frequently-occurring hemorrhage, through wound surface hydrogen peroxide, clean, powder of the present invention is spread to wound surface, pressure dressing, wound surface is hemorrhage stops, within 1st, changing dressings once, wound healing after 7 days.
Grandson * *, man, 70 years old, diabetic history 20 years, sky takes blood glucose 14mnol/l, urine examination ++, left lower extremity ulcer gangrene 3 years, ulcer is numb around, feel to go down, there is hospital's suggestion amputation, oral administration hypoglycemic medicine, glycemic control is in 6.5mnol/l left and right, rear employing Chinese medicine of the present invention, after local debridement, powder of the present invention is modulated into pasty state unguentum with Oleum sesami, is coated on wound surface and pours into sinus tract, within 1st, change dressings once, wound surface purulent secretion obviously reduces, wound surface incrustation after 14 days, after 21 days, sinus tract is closed, wound healing.
Lee * *, female, 15 years old, left leg insect-bite, local red and swollen broken knot, the shiver with cold of companion's whole body, heating, wound surface is sterile-processed, local external application powder of the present invention (the pasty state unguentum being modulated into Chinese medicine of the present invention and 0.9% normal saline), after three days, redness disappears, General Symptoms is clearly better, red and swollen disappearance after five days, recovery from illness.
Poplar * *, man, 17 years old, the shallow ∏ degree of left forearm 3% is scalded, severe pain, there is blister part, and wound surface is red, part is cleaned with hydrogen peroxide, powder of the present invention and Oleum sesami are spread on to wound surface by 45:55 adjustment paste making agent, and pain obviously alleviates, and the next day changes dressings once, wound healing after 6 days, does not stay pigmentation and cicatrix.
Open XX, female, 82 years old, suffer from arterial obliterans of lower extremity more than two decades, two lower limb are walked lamely more than ten years, carrying out property increases the weight of, two numbness of lower limbs fear of cold, and left sufficient cold injury, wound surface size 3cmx3.5cm, wound surface is pale, red and swollen around, common changing dressings 2 months, wound is prolonged does not heal, and wound surface expands gradually.Through debridement, and adopt powder of the present invention to spread on wound surface, the next day, changes dressings, and after one week, wound surface is reduced into 2cmx2cm gradually, through 3 weeks, adopts this powder to change dressings, and wound is fully recovered gradually, in two years not recurrence.
Claims (1)
1. a Chinese medicine for the treatment of wound and bran urine foot disease ulcer, is characterized in that: the raw material of described Chinese medicine forms and mass parts ratio is: RHIZOMA BISTORTAE 2; Rhizoma Paridis 1; Rhizoma Arisaematis (processed) 1; Rhizoma Kaempferiae 1; Radix Arnebiae (Radix Lithospermi) 0.5.
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