CN103393782A - Traditional Chinese medicine composition with function of resolving stagnation for tranquilization, preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition with function of resolving stagnation for tranquilization, preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with a function of resolving stagnation for tranquilization. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 10-15 parts of cortex albiziae, 10-20 parts of tuber fleeceflower stem, 10-20 parts of jujube kernel, 6-12 parts of lucid ganoderma, 15-30 parts of Astragalus membranaceus and 10-15 parts of Angelica sinensis. Animal and clinical experiments show that the traditional Chinese medicine composition has a good effect of inducing and prolonging sleep, exerts a good sedation effect while treating insomnia, and has a good curative effect to symptoms such as depression, anxiety and irritability. The traditional Chinese medicine composition is in particular suitable for the old, children and critical patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition with resolving stagnation for tranquilization effect, preparation and preparation method thereof.
Background technology
Insomnia, be called as " being insomnia " in Difficult Classic, be referred to as " must not crouch " " unable to close the eyes " in " interior warp ", insomnia is often can not obtain the class disease of ortho sleep as feature, main manifestations is that the length of one's sleep, the degree of depth are not enough, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking or wake up after can not sleep again, severe one is lain awake all night.
Sleep is the necessary physiological phenomenon of human life activity, and is closely bound up with health, and sleep disorder tends to cause body immunity, hypomnesis, produces the unhealthy emotions such as anxiety, also easily brings out simultaneously hypertension, neurasthenia, even causes sudden death.According to investigations, the people of China 55% has insomnia in various degree, and 17% people is quite serious, and the old people has accounted for whole insomnia crowd's 70%.Therefore people's orthobiosis is arrived in the serious threat of having a sleepless night.
Insomniac is subject to the impact of many factors, and the characteristics of outbreak are arranged repeatedly, thus in treatment except Drug therapy, the psychotherapy is unusual necessity also.The western medical treatment insomnia except psychological consultation, mainly uses 3 large class sleeping pill, i.e. Benzodiazepines, barbiturates and other non-barbiturateses, and require to take the patient of sleeping pill can not steering vehicle or operate machine, to avoid accident.Doctor trained in Western medicine thinks that it is unsuitable that the child uses sleeping pill, and the gerontal patient also should be prudent in medication, and hepatic and renal function the person of going down be cautious use of, women breast-feeding their children and contraindication in pregnancy.The medicine of the insomnia for the treatment of by Chinese herbs at present is various, but the effect to resolving depression is also not obvious, although a lot of patients are because the insomnia that the emotions such as depression cause is alleviated to some extent, but as its insomnia of resolving depression not, can't be effected a radical cure, because the Chinese medicine ingredients side effect is larger, existing medicine is to the particular patients ' colonies such as patient with severe symptoms or cancer patient and inapplicable.
Summary of the invention
Primary and foremost purpose of the present invention be to solve the problem of prior art and propose a kind ofly have anxiety, the Chinese medicine composition of the resolving depression of calming the nerves, Cure for insomnia effect, be particularly useful for patient with severe symptoms or cancer patient.
A further object of the present invention is to propose a kind of method for preparing above-mentioned Chinese medicine composition.
The 3rd purpose of the present invention is to propose a kind ofly have anxiety, the Chinese medicine preparation of the resolving depression of calming the nerves, Cure for insomnia effect.
The present invention selects Cortex Albiziae, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Ganoderma, the Radix Astragali, Radix Angelicae Sinensis Six-element Chinese medicine composition, makes each medicine play synergism, thereby can effectively play the resolving depression of calming the nerves, anxiety effect.The brief introduction of Six-element medicine is as follows:
Cortex Albiziae: nature and flavor are sweet flat, enter the heart, Liver Channel, the kind stagnation of liver-QI of separating.
Caulis Polygoni Multiflori: this product sweet in the mouth, enter the heart, liver two warps, can take a tonic or nourishing food to build up one's health cloudy blood, be applicable to the insomnia and dreamful sleep of deficiency of YIN insufficiency of blood, malaise, the diseases such as the vertigo.Modern pharmacological research shows: sedative-hypnotic effect is arranged, with pentobarbital sodium, share obvious synergism; The Caulis Polygoni Multiflori alcohol extract can suppress the experimental rat hyperlipemia; Experimental atherosclerosis there is certain preventive and therapeutic effect; And can the Promote immunity function.
Semen Ziziphi Spinosae: this product sweet in the mouth, enter the heart, Liver Channel, the moon can nourish heart.Cure mainly the conscience deficiency of YIN-blood, that the heart is become homeless is foster, cardiopalmus, palpitation with a distress feeling, the disease such as forgetful, dizzy.
Ganoderma: this product sweet in the mouth is flat, enters heart channel, can reinforcing the heart blood, the beneficial motive, therefore can be used for treating the diseases such as malaise due to insufficiency of vital energy and blood, lack of preservation of spirit, insomnia, palpitation with fear, dreaminess, forgetful, the tired Mental fatigue of body, lack of appetite.
The Radix Astragali: the sweet temperature of this product, be apt to into taste, be the invigorating the spleen and replenishing QI key medicine, this product enters lung again can replenishing and restoring lung-QI and tonifying QI to promote blood circulation, ascending up spleen-Qi and Yang, benefit is defended consolidating superficial resistance.Modern pharmacological research shows: Radix Astragali energy enhancing human body immunity function, improve effect and heart tonifying, adjusting blood pressure, the antiviral property myocarditiss such as substance metabolism, anti-stress, slow down aging, protect the liver, the effect such as antiulcer, astragalus polysaccharides and Radix Astragali saponin are its main effective ingredient.
Radix Angelicae Sinensis: the sweet Wen Zhirun of this product, be longer than and enrich blood, be the panacea of enriching blood, the hot row temperature of this product is logical, is the key medicine of blood circulation promoting competent silt.
In order to realize purpose of the present invention, the present invention adopts following concrete technological means:
A kind of Chinese medicine composition with resolving stagnation for tranquilization effect, the crude drug of described Chinese medicine composition is: Cortex Albiziae 10～15 weight portions, Caulis Polygoni Multiflori 10～20 weight portions, Semen Ziziphi Spinosae 10～20 weight portions, Ganoderma 6～12 weight portions, the Radix Astragali 15～30 weight portions, Radix Angelicae Sinensis 10～15 weight portions.
Described traditional Chinese medicinal composition raw materials optimum weight part proportioning is: Cortex Albiziae 12 weight portions, Caulis Polygoni Multiflori 15 weight portions, Semen Ziziphi Spinosae 15 weight portions, Ganoderma 9 weight portions, the Radix Astragali 20 weight portions, Radix Angelicae Sinensis 12 weight portions.
A kind of above-mentioned preparation method with Chinese medicine composition of resolving stagnation for tranquilization effect, under described method step:
(1) extract front the immersion: described crude drug was soaked 15～60 minutes in water, amount of water was not to have crude drug to be as the criterion;
(2) boil water extraction twice, extracted for the first time 20～45 minutes, extracted for the second time 15～35 minutes;
(3) decocting medicinal liquid with twice after the filtration merges and get final product.
A kind of Chinese medicine extract with resolving stagnation for tranquilization effect, described Chinese medicine extract is prepared by said method.
The purposes of described Chinese medicine extract in preparing the resolving stagnation for tranquilization Chinese medicine preparation.
On the Chinese medicine extract that a kind of Chinese medicine preparation with resolving stagnation for tranquilization effect, described Chinese medicine preparation are prepared by said method and pharmaceutics, acceptable adjuvant is made.
The present invention also can make oral powder through simply being pulverized and mixed, and also can utilize the preparation method of Chinese materia medica field routine that the upper acceptable adjuvant of rear adding medicine of Chinese medicine composition extraction is made oral formulations.Best oral formulations is decoction, oral liquid, granule, tablet, sweet mastic or capsule.
Recommendation instructions of taking of the present invention is: take every day 2～3 times, each 200～250 milliliters, 15 days is a course for the treatment of.
Beneficial effect of the present invention is:
Confirm through zoopery and clinical experiment, Chinese medicine composition of the present invention has the effect of well inducing and extending sleep, can bring into play good sedation in Cure for insomnia, and the symptoms such as depression, anxiety, irritability are also had good curative effect.Be particularly useful for old man child and patient with severe symptoms.
Description of drawings
Figure 1A is GABA
A-α
1Solubility curve;
Figure 1B is GABA
A-α
1Amplification curve;
Fig. 2 A is GABA
A-α
2Solubility curve;
Fig. 2 B is GABA
A-α
2Amplification curve;
Fig. 3 A is β-actin solubility curve;
Fig. 3 B is β-actin amplification curve;
Fig. 4 is the mrna expression level of GABAA-α 1 receptor in each group Hippocampus of Mice; Compare * * P＜0.01 (n=10) with the blank group.
Fig. 5 is the mrna expression level of GABAA-alpha-2 receptor in each group Hippocampus of Mice; Compare * * P＜0.01 (n=10) with the blank group.
The specific embodiment
The present invention's medical material used, all available from Chinese Medicinal Materials Co, meets 2000 editions ministerial standards of Pharmacopoeia of People's Republic of China.
The preparation of embodiment 1 Chinese medicine composition of the present invention
Component and consumption:
Cortex Albiziae 12g, Caulis Polygoni Multiflori 15g, Semen Ziziphi Spinosae 15g, Ganoderma 9g, Radix Astragali 20g, Radix Angelicae Sinensis 12g
Preparation method:
(1) above-mentioned medical material is put with in marmite by above dosage, added pure water, amount of water, not have medical material 2～3 fingers to be advisable, soaked 30 minutes;
(2) boil water extraction twice, extraction conditions: intense fire (i.e. strong fire) is used slow fire (i.e. weak fire) instead after boiling, remain on slight boiling condition, decocts 30 minutes, pours out medicinal liquid.Attention: this moment, medicinal residues were hot, so use slow fire instead after the second extraction decoction wants heating water extremely to seethe with excitement, started to extract 20 minutes, and medicinal liquid is poured out;
(3) decoct medicinal liquid with twice and merge, take 2～3 every day and take, each 200～250 milliliters.
The preparation of embodiment 2 Chinese medicine compositions of the present invention
Component and consumption:
Cortex Albiziae 10g, Caulis Polygoni Multiflori 20g, Semen Ziziphi Spinosae 10g, Ganoderma 12g, Radix Astragali 15g, Radix Angelicae Sinensis 10g
Preparation method:
(1) above-mentioned medical material is put with in marmite by above dosage, added pure water, amount of water, not have medical material 2～3 fingers to be advisable, soaked 60 minutes;
(2) boil water extraction twice, extraction conditions: intense fire (i.e. strong fire) is used slow fire (i.e. weak fire) instead after boiling, remain on slight boiling condition, decocts and extracts 45 minutes, pours out medicinal liquid.Attention: this moment, medicinal residues were hot, so use slow fire instead after the second extraction decoction wants heating water extremely to seethe with excitement, started to extract 35 minutes, and medicinal liquid is poured out;
(3) decoct medicinal liquid with twice and merge, take 2～3 every day and take, each 200～250 milliliters.
The preparation of embodiment 3 Chinese medicine compositions of the present invention
Component and consumption:
Cortex Albiziae 15g, Caulis Polygoni Multiflori 10g, Semen Ziziphi Spinosae 20g, Ganoderma 6g, Radix Astragali 30g, Radix Angelicae Sinensis 15g
Preparation method:
(1) above-mentioned medical material is put with in marmite by above dosage, added pure water, amount of water, not have crude drug 2～3 fingers to be advisable, soaked 15 minutes;
(2) boil water extraction twice, extraction conditions: intense fire (i.e. strong fire) is used slow fire (i.e. weak fire) instead after boiling, remain on slight boiling condition, decocts and extracts 20 minutes, pours out medicinal liquid.Attention: this moment, medicinal residues were hot, so use slow fire instead after the second extraction decoction wants heating water extremely to seethe with excitement, started to extract 15 minutes, and medicinal liquid is poured out;
(3) decoct medicinal liquid with twice and merge, take 2～3 every day and take, each 200～250 milliliters.
The preparation of embodiment 4 granules of the present invention
Component and consumption:
Cortex Albiziae 13g, Caulis Polygoni Multiflori 18g, Semen Ziziphi Spinosae 16g, Ganoderma 11g, Radix Astragali 20g, Radix Angelicae Sinensis 13g
Preparation method:
(1) above-mentioned medical material is put with in marmite by above dosage, added pure water, amount of water, not have crude drug 2～3 fingers to be advisable, soaked 45 minutes;
(2) boil water extraction twice, extraction conditions: intense fire (i.e. strong fire) is used slow fire (i.e. weak fire) instead after boiling, remain on slight boiling condition, decocts and extracts 40 minutes, pours out medicinal liquid.Attention: this moment, medicinal residues were hot, so use slow fire instead after the second extraction decoction wants heating water extremely to seethe with excitement, started to extract 30 minutes, and medicinal liquid is poured out;
(3) decoct medicinal liquid with twice and merge, filtering and concentrating is 1.3～1.34 thick paste to relative density, adds the adjuvant spray granulation, and dry packing gets final product.
Effect experiment of the present invention
The pharmacology pharmacodynamic test, result is as follows:
1. on the impact of mice autonomic activities
With 50 Kunming mouses, male and female half and half, be divided into 5 groups at random, 10 every group, is respectively: blank group, positive control diazepam group, embodiment 1 prepare extract low dose group, middle dosage group, high dose group.Each is organized mice and puts into respectively the active box of JZZ-98 type mice autonomic activities detector, then starts monitor and records movable number of times in its 3min.Blank group gavage gives distilled water, and positive controls gives diazepam according to the 2mg/kg gavage, and the gavage amount of basic, normal, high each group of hypnosis side's water extract is respectively 1,2,4g/kg, according to Mice Body weight gavage, gives hypnosis side's water extract.Each experimental group gavage every day 1 time, 7d, after last administration 30min, measure mice autonomic activities number of times continuously.
The impact (n=10) of table 1 hypnosis side water extract on the mice autonomic activities
Annotate: with the blank group, compare
aP＜0.01,
bP＜0.05.
As shown in Table 1, the basic, normal, high dosage group of the present invention mice autonomic activities number of times is significantly less than the blank group, and high dose group of the present invention obviously is better than positive controls.
2. on the impact of sub-threshold dose pentobarbital sodium sedation
Get 50 Kunming mouses, male and female half and half, be divided into 5 groups at random, 10 every group, is respectively: blank group, positive control diazepam group, the basic, normal, high dosage group of hypnosis side's water extract, embodiment 1 extract is respectively organized the gavage amount and is respectively 1,2,4g/kg.Every day, gavage was 1 time, administration 7d.Each group all after last administration 60min,, according to Mouse Weight injection sub-threshold dose pentobarbital sodium 20mg/kg, records the number of elements of falling asleep, Sleep latency (from the injection pentobarbital sodium, to righting reflex loss, being Sleep latency) and the length of one's sleep in 60min., for falling asleep, with righting reflex loss, to righting reflex, revert to the length of one's sleep with the above person of righting reflex loss 1min.The person's of not falling asleep Sleep latency is decided to be 60min.
The impact (n=10) of table 2 hypnosis side water extract on sub-threshold dose pentobarbital sodium sedation
Annotate: with the blank group, compare
aP＜0.01,
bP＜0.05.
3. on the above threshold impact of dosage pentobarbital sodium sedation
Method is with above-mentioned, and after last administration 60min, each is organized mouse peritoneal and injects the above threshold pentobarbital sodium 40mg/kg of dosage, records Sleep latency and the length of one's sleep.
Table 3 hypnosis side water extract is on the above threshold impact of dosage pentobarbital sodium sedation (n=10)
Annotate: with the blank group, compare
aP＜0.01,
bP＜0.05.
Above-mentioned table 2, table 3 result show: the basic, normal, high dosage group of the present invention can under threshold and the above threshold sleep of dosage pentobarbital sodium mice play synergism, have inducing and extend the effect of mice sleep.
In order further to study the tranquilizing soporific mechanism of hypnosis side, we have carried out the research of neuropharmacology aspect to hypnosis side, the GABAA receptor is the action target spot of clinical neuroactive drug commonly used, Benzodiazepine (Benzodiazepine, BDZ) class medicine is brought into play the effect of tranquilizing soporific by it.This experiment, as drug target, detects the impact of hypnosis side on hippocampus of mice GABAA Receptor mRNA to the GABAA receptor by Real-Time Fluorescent Quantitative PCR Technique, is intended to inquire into the molecular mechanism of hypnosis side's performance sedative-hypnotic effect.
1. employing random packet, with 30 Kunming mouses, male and female half and half, be divided into 3 groups at random, 10 every group, is respectively: blank group, positive diazepam group, hypnosis side's group.Blank group gavage gives the distilled water of same volume, and positive group gives diazepam according to the 2mg/kg gavage, and the gavage amount of hypnosis side's group is 2g/kg, according to Mice Body weight gavage, gives respectively to organize medicine.Each experimental group gavage every day 1 time, 7d continuously.Each administration group gastric infusion after continuous 7 days, after last administration 10min, takes off neck and puts to death, and takes out rapidly brain, and sharp separation goes out Hippocampus on ice pan, puts immediately in liquid nitrogen, and is frozen stand-by in-80 ℃ of cryogenic refrigerators subsequently.
2. the amplified production solubility curve is analyzed
It is all unimodal that GABAA-α 1, GABAA-α 2 dissolve peak with β-actin, and is characteristic peak, illustrates that pcr amplification is specific amplification.Figure 1A B, Fig. 2 AB, Fig. 3 AB are respectively GABAA-α 1, GABAA-α 2 and β-actin solubility curve and amplification curve.
Analyze the specificity of judgement PCR reaction by Figure 1A B, Fig. 2 AB, Fig. 3 AB curve, to dissolve peak be all unimodal and be characteristic peak, and the pcr amplification of illustrative experiment is specific amplification.GABAA-α 1, GABAA-α 2 and β-actin dissolving peak is all unimodal and is all characteristic peak in this experiment, and the pcr amplification that this experiment is described is specific amplification.This experiment demonstrate,proved the GABAA receptor biological function and with the insomnia relation, also from the another one angle, explained simultaneously the biomolecule mechanism of hypnosis side's performance sedative-hypnotic effect, namely the sedative-hypnotic effect of hypnosis side may be mainly that the expression that specificity increases GABAA receptor alpha 1 subunit causes.
4. hypnosis side analyzes GABAA receptor mrna qPCR
Each is organized GABAA receptor gene and increases through qPCR, and its parametric statistics of respectively organizing the mrna expression level the results are shown in Figure 4 and Fig. 5.Can be found out by Fig. 4 and Fig. 5, compare with the blank group, hypnosis side's group mice GABAA-α 1 receptor mrna level obviously raises (P＜0.01) and is better than positive diazepam group; And hypnosis side group mice GABAA-alpha-2 receptor mRNA level does not have obvious castering action.
This experimental result shows: positive group medicine diazepam can increase the expression of α 1 and α 2 subunits in hippocampus of mice simultaneously, ω 1 and ω 2 do not had selectivity, so in performance anxiety and sedative-hypnotic effect, have the side effect such as of flaccid muscles, hypomnesis, tolerance and addiction; Hypnosis side only increases the expression of α 1 subunit, and the expression of α 2 subunits is had no significant effect, and illustrates that hypnosis can optionally act on ω 1 receptor, but does not affect ω 2 receptors, therefore can avoid by side effect such as ω 2 receptor-mediated Cognitive function damagies.Hypnosis side is at Cure for insomnia, and performance sedative-hypnotic effect aspect is better than BDZ class medicine.
Clinical experiment and interpretation of result:
1. case: select 1 above insomniac of week, the age is more than 25 years old, difficulty falling asleep, and dreaminess, the frequency of having a sleepless night is high, affects quality of life and with certain symptom (irritability, anxiety, tired etc.), even the energy of sleeping also recovers bad person.
The experiment grouping: take the randomized controlled trial method, be divided into two groups, treatment group 55 examples, matched group 50 examples, treat front two groups and carry out statistical analysis at aspects such as age, sex, the courses of disease, has comparability.
Method: the contrast medicine is diazepam tablets, the front clothes of sleeping, 2.5mg～5mg; Embodiment 1 prepares the resolving depression side's water decoction of calming the nerves, every day 2 times, each 200～250ml.
Efficacy assessment standard: cure: sleep is normal, can sleep every day more than 6 hours, and simultaneous phenomenon disappears; Effectively: extend the length of one's sleep more than 1 hour, need not take sleeping pill, simultaneous phenomenon improves; Invalid: symptom is without changing or extending less than the length of one's sleep 1 hour.The results are shown in Table 4.
Table 4
Above-mentioned clinical experiment result show we the bright described resolving depression of calming the nerves Chinese medicine composition compare and have good effect with matched group, total effective rate reaches 100%.The decoction that the inventor utilizes again embodiment 2,3 to prepare is tested equally, and result is with embodiment 1.
2. case: gerontal patient, women, 65 years old.My old man is dead before 4 years, and it is caused very large compression of nerves, causes sleep disorder, and the Chinese and western medicine poor effect of seeking medical advice, be admitted to hospital because sleep disorder causes repeatedly hypertensive crisis emergency treatment.After treating 1 course for the treatment of by this side, can sleep 4～5 hours every day, and after 2 courses for the treatment of, slept 5～6 hours every day, and hypertension is controlled at normal range, takes care of oneself and can help daughter to pick the grandson and go to school.
3. case: select cancer patient's 50 examples of above insomnia of 1 week, 40～60 years old age, because cancer pressure causes difficulty falling asleep, dreaminess, the insomnia frequency is high, affects quality of life and with certain symptom (irritability, anxiety, tired etc.), even the energy of sleeping also recovers bad person.
The experiment grouping: take the randomized controlled trial method, be divided into two groups, treatment group 25 examples, matched group 25 examples, treat front two groups and carry out statistical analysis at aspects such as age, sex, the courses of disease, has comparability.
Method: the contrast medicine is diazepam tablets, the front clothes of sleeping, 2.5mg～5mg; Embodiment 1 prepares the resolving depression side's water decoction of calming the nerves, every day 2 times, each 250ml.
Efficacy assessment standard: cure: sleep is normal, can sleep every day more than 6 hours, and simultaneous phenomenon disappears; Effectively: extend the length of one's sleep more than 1 hour, need not take sleeping pill, simultaneous phenomenon improves; Invalid: symptom is without changing or extending less than the length of one's sleep 1 hour.The results are shown in Table 5.
Table 5
Claims (8)
1. Chinese medicine composition with resolving stagnation for tranquilization effect, it is characterized in that, the crude drug of described Chinese medicine composition is: Cortex Albiziae 10～15 weight portions, Caulis Polygoni Multiflori 10～20 weight portions, Semen Ziziphi Spinosae 10～20 weight portions, Ganoderma 6～12 weight portions, the Radix Astragali 15～30 weight portions, Radix Angelicae Sinensis 10～15 weight portions.
2. the Chinese medicine composition with resolving stagnation for tranquilization effect as claimed in claim 1, it is characterized in that, the crude drug of described Chinese medicine composition is: Cortex Albiziae 12 weight portions, Caulis Polygoni Multiflori 15 weight portions, Semen Ziziphi Spinosae 15 weight portions, Ganoderma 9 weight portions, the Radix Astragali 20 weight portions, Radix Angelicae Sinensis 12 weight portions.
3. the described preparation method with Chinese medicine composition of resolving stagnation for tranquilization effect of claim 1 or 2, is characterized in that comprising the steps:
(1) extract front the immersion: the described crude drug of claim 1 or 2 was soaked 15～60 minutes in water, amount of water was not to have crude drug to be as the criterion;
(2) boil and carry twice, extracted for the first time 20～45 minutes, extracted for the second time 15～35 minutes;
(3) decocting medicinal liquid with twice merges and get final product.
4. the Chinese medicine extract with resolving stagnation for tranquilization effect, is characterized in that, described Chinese medicine extract is prepared by the described method of claim 3.
5. the purposes of the described Chinese medicine extract of claim 4 in preparing the resolving stagnation for tranquilization Chinese medicine preparation.
6. the Chinese medicine preparation with resolving stagnation for tranquilization effect, is characterized in that, on the Chinese medicine extract that described Chinese medicine preparation is prepared by claim 3 and pharmaceutics, acceptable adjuvant is made.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that, described Chinese medicine preparation is oral formulations.
8. Chinese medicine preparation as claimed in claim 7, is characterized in that, described oral formulations is decoction, oral liquid, granule, tablet, sweet mastic or capsule.
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