CN103386110B - Chinese medicine composition, and preparation method and applications thereof - Google Patents
Chinese medicine composition, and preparation method and applications thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition. The Chinese medicine composition comprises the following raw materials in parts by weight: 3-15 parts of ginseng, 3-15 parts of rhizome zingiberis, 2-10 parts of cortex cinnamomi, 7-35 parts of orange peels, 3-15 parts of rhizome dioscoreae, 5-25 parts of fructus jujubae, 1-20 parts of poria cocos, 1-60 parts of white hyacinth beans, 1-20 parts of citrus chirocarpus, 1-10 parts of semen raphani, 1-120 parts of black tea, 0-150 parts of radix codonopsis, 0-50 parts of American ginseng, 0-50 parts of sweet-scented osmanthus, 0-30 parts of semen myristicae, 0-60 parts of fresh ginger, 0-20 parts of endothelium corneum gigeriae galli, and 0-30 parts of fructus hordei germinatus. The invention further provides a preparation method of the Chinese medicine composition, and applications of the Chinese medicine composition in the fields of medicaments, health-care products, food and the like. The medicaments, health-care products or food are prepared from multiple herbal Chinese medicines which are coordinated in compatibility, take advantages of each other and are safe and effective, so that the good mouthfeel and safety of the products can be guaranteed, the bitter and astringent taste of medicaments can be avoided, and the Chinese medicine composition has the effects of tonifying the spleen, warming up the stomach, and improving the gastrointestinal function.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and application, particularly a kind of have spleen invigorating warming the stomach, the Chinese medicine composition improving gastrointestinal function, its preparation method and its application in medicine, health product, food industry.
Background technology
Along with improving constantly of social development and living standards of the people, health index but declines increasingly, and most people is in sub-health state, and is tending towards multi-population, the situation of rejuvenation.Bad diet, daily life and allegro life easily cause that taste are impaired, raw in deficiency and coldness, symptom/the disease showed in modern medicine mostly is the gastroenteropathys such as inappetence, greatly loose stool are thin, chronic enterogastritis, functional dyspepsia, peptic ulcer, chronic colitis, therefore have the product for the treatment of and recuperating gastrointestinal tract function, its demand is also increasing.
There is tonify deficiency warming the stomach spleen invigorating in the market thus regulate the health product of gastrointestinal function, food less, being in certain market vacancy state, the present invention is directed to this present situation, develop one and there is warming and invigorating the spleen and stomach, be applicable to the product of mass consumption.
Summary of the invention
The present invention provide firstly a kind of Traditional Chinese medicine composition formula, and described Chinese medicine composition is made primarily of the raw material of following weight proportion: Radix Ginseng 3-15 part, Rhizoma Zingiberis 3-15 part, Cortex Cinnamomi 2-10 part, Pericarpium Citri tangerinae 7-35 part, Rhizoma Dioscoreae 3-15 part, Fructus Jujubae 5-25 part, Poria 1-20 part, Semen Lablab Album 1-60 part, Fructus Citri Sarcodactylis 1-20 part, Semen Raphani 1-10 part, black tea 1-120 part, Radix Codonopsis 0-150 part, Radix Panacis Quinquefolii 0-50 part, Flos Osmanthi Fragrantis 0-50 part, Semen Myristicae 0-30 part, Rhizoma Zingiberis Recens 0-60 part, Endothelium Corneum Gigeriae Galli 0-20 part and Fructus Hordei Germinatus 0-30 part.
As a kind of preferred version, described Chinese medicine composition is made primarily of the raw material of following weight proportion: Radix Ginseng 15 parts, Rhizoma Zingiberis 15 parts, Cortex Cinnamomi 10 parts, Pericarpium Citri tangerinae 35 parts, Rhizoma Dioscoreae 15 parts, 25 parts, Fructus Jujubae, 10 parts, Poria, Semen Lablab Album 30 parts, Fructus Citri Sarcodactylis 10 parts, Semen Raphani 5 parts, black tea 60 parts.
One as described Chinese medicine composition is applied, present invention also offers a kind of medicine or the health food that comprise above-mentioned Chinese medicine composition, described medicine containing above-mentioned Chinese medicine composition or health food can also add in following adjuvant or additive one or more: diluent, excipient, lubricant, disintegrating agent and correctives etc., and the dosage form of described medicine or health product can be the dosage forms such as granule, tablet, pill, powder, oral liquid or capsule.
Another kind as described Chinese medicine composition is applied, present invention also offers a kind of food comprising above-mentioned Chinese medicine composition, the described food containing above-mentioned Chinese medicine composition also can add in following adjuvant or additive one or more: acidity regulator, anticaking agents, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, colour fixative, enzyme preparation, flavour enhancer, nutrition enhancer, antiseptic, sweeting agent, thickening agent and spice etc.; And described food form can be graininess or Powdered alternative tea, beverage, cake or confection etc.
Correspondence the invention provides the preparation method of a kind of medicine of described Chinese medicine composition, health food or food, and this preparation method comprises the steps:
(1) described starting material with water or ethanol water are extracted, by extracting liquid filtering, concentrate;
(2) spraying dry, optionally adds adjuvant or additive, pelletizing forming, packaging sterilizing.
Preferably, after described step (1) can be and described raw material is soaked 1 hour, heating extraction 1-4 time, each 1-2 hour, each amount of water is the 8-10 times amount of described raw material, by extracting solution merging, filtration, cold preservation, leaves standstill, centrifugal removing impurity, concentrated.
Preferably, described step (1) of stating also can be and to be added by described raw material after ethanol water soaks 1 hour, heating extraction 1-4 time, each 1-2 hour, add the 5-7 times amount that ethanol water amount is described raw material at every turn, by extracting liquid filtering, merging, cold preservation, standing, filtration, reclaim ethanol, concentrated; Wherein, as preferred embodiment, the concentration of described ethanol water is 70%(v/v).
As another kind of preferred implementation, described step (2) comprises, spraying dry obtains former powder, add certain proportion brown sugar, white sugar, dextrin fine powder, its Central Plains powder and brown sugar ratio are 1:0-4, and former powder and white sugar ratio are 1:0-4, former powder and cyclodextrin ratios are 1:0.5-1.5, make granule, packaging, sterilizing.
Present invention also offers a kind of comprise described Chinese medicine composition preparation method, this preparation method comprises the steps:
(1) pulverize and sieve after the described raw material successively removal of impurity;
(2) optionally add adjuvant or additive, pack after packaging or soft bake, after sterilizing and get final product; Wherein said soft bake preferably carries out at 80-150 DEG C.
Or this preparation method comprises the steps:
(1) described starting material with water or ethanol water are extracted, by extracting liquid filtering, concentrate;
(2) add water and other adjuvants, mix homogeneously, cold preservation leaves standstill, and filters, adds beverage and commonly use correctives and other adjuvants, fine straining, fill, sterilizing.
In side, Rhizoma Zingiberis, Cortex Cinnamomi are monarch, and the large heat of great Xin, returns through taste, and the logical cold relieving of temperature, invigorating YANG presses down cloudy.Enter spleen, invigorating the spleen and replenishing QI with Radix Ginseng, Fructus Jujubae, Rhizoma Dioscoreae for minister, Gan Wen, train and mend the foundation of acquired constitution, gas is prosperous and sun is also multiple.Spleen is wet soil, and middle void is not transported, and must give birth to damp, and with Pericarpium Citri tangerinae, Poria, Semen Lablab Album, Fructus Citri Sarcodactylis for assistant, damp eliminating spleen invigorating, strong fortune Central Region, the institute of throwing spleen likes.Semen Raphani, black tea help digestion de-swelling, help gastro-intestinal digestion, promote appetite, with for making medicine, scalable spleen and stomach function.
Therefore, medicine provided by the invention, health product or food adopt plurality of Chinese, and mutual compatibility is coordinated, respectively get the chief, safe and effective, ensure that good taste and the safety of product, avoid the pained abnormal smells from the patient of medicine, there is spleen invigorating warming the stomach simultaneously, improve the effect of gastrointestinal function.The present invention adopts pure natural raw material, and raw material is easy to get, and has no side effect, and has good market prospect.Modern pharmacology test shows, gut hormone index can disclose the associated gastrointestinal locomotory mechanism of syndrome of spleen-deficiency from microcosmic point, " syndrome of spleen-deficiency " of Traditional Chinese Medicine can be given with modern science implication, and can be tcm clinical practice and effectively treat syndrome of spleen-deficiency gut hormone evaluation index and foundation are provided.Experiment shows, medicine provided by the invention, health product or food obviously can improve the stool of MOTIVITY IN RAT MODEL, comprise the level of gut hormone of gastrin (GAS), motilin (MTL), somatostatin (SS).
Detailed description of the invention
More easily be understood to make technical scheme of the present invention, below in conjunction with specific embodiment, the present invention is further elaborated, embodiment described herein is only section Example of the present invention, but not whole implementation of the present invention, described embodiment only has exemplary, instead of limits the exhaustive of technical scheme of the present invention.Without departing from the inventive concept of the premise; all those of ordinary skill in the art do not make creative work just other embodiment thinkable; and other is to the simple replacement of technical solution of the present invention and various common variation, all belongs to protection scope of the present invention.Described method is conventional method if no special instructions.Described raw material all can obtain from open commercial sources if no special instructions.
Embodiment 1
Get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g carry out the removal of impurity successively, and be crushed to 24 orders, be divided into 100 teabag unit quantities, load tea bag, sterilizing, obtains the teabag of Chinese medicine composition of the present invention.
Embodiment 2
Get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 10 times amount water soaking 1 hour, heating decoction 3 times, each 1 hour, add water 10 times amount for the first time, rear 8 times amount that add water for twice, merge three extracting liquid filterings, filtrate cold preservation leaves standstill 24 hours, get supernatant, high speed centrifugation remove impurity, after filtrate is concentrated into relative density 1.2, spraying dry obtains former powder, add certain proportion brown sugar (1:1), white sugar (1:3), dextrin (1:1) fine powder, mix homogeneously, by granule common process, dryly be crushed to granule, packaging, sterilizing.
Embodiment 3
Get Radix Ginseng 15 g, Rhizoma Zingiberis 15g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 70%(v/v) ethanol water soaks 1 hour, heating and refluxing extraction 3 times, each 1 hour, first time adds 7 times amount, add 5 times amount for twice afterwards, filter, merge three filtrates, filtrate cold preservation leaves standstill 24 hours, get supernatant, high speed centrifugation remove impurity, heating recovery ethanol is extremely without after alcohol taste, be concentrated into certain density, spraying dry, obtain former powder, add certain proportion brown sugar (1:1), white sugar (1:3), dextrin (1:1) fine powder, mix homogeneously, by granule common process, dryly be crushed to granule, packaging, sterilizing.
Embodiment 4
Get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material soaks 1 hour, heating decoction 3 times, each 1 hour, add water 10 times amount at every turn, merge three extracting solution and use 120-200 mesh screen, filtrate reduced in volume is to thick extractum, add a certain amount of ethanol water, mix homogeneously, cold preservation leaves standstill 24-48 hour, get supernatant, high speed centrifugation, remove impurity, filtrate heating recovery is extremely without alcohol taste, be concentrated into certain density, add a certain amount of citric acid, the tea beverage such as acesulfame potassium commonly use correctives and other adjuvants, mix homogeneously, fine straining, fill, sterilizing, obtain beverage.
Embodiment 5
Get Radix Ginseng 15g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30g, Fructus Citri Sarcodactylis 10g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 70%(v/v) ethanol water soaks 1 hour, heating and refluxing extraction 3 times, each 1 hour, first time adds 7 times amount, add 5 times amount for twice afterwards, filter, merge three filtrates, filtrate cold preservation leaves standstill 24-48 hour, get supernatant, high speed centrifugation remove impurity, reclaim ethanol extremely without after alcohol taste, be evaporated to certain density, add water and other adjuvants, mix homogeneously, cold preservation leaves standstill 24-48 hour, get supernatant, high speed centrifugation, remove impurity, add a certain amount of citric acid, the tea beverage such as acesulfame potassium commonly use correctives and other adjuvants, mix homogeneously, fine straining, fill, sterilizing, obtain beverage.
Embodiment 6
Pharmacological evaluation: get SD rat 50, be divided into 5 groups at random: Normal group, model of spleen deficiency group, group 1(give the teabag of embodiment 1), group 2(gives the granule of embodiment 2), group 3(gives the beverage of embodiment 3), each group 10, wherein according to document (Wang Honghai, Xie Ming. the change ［ J ］ of model of spleen-asthenia hemorheology of rat and TXB2,6-Keto-PGF1 α. Beijing University of Chinese Medicine's journal, 2007,30 (11): 761-765) method copies rat Bi-syndrome with spleen deficiency.Carry out gavage to rat after 10 days, gavage 10mL/kg, observed its general character and measured motilin (MTL) in its venous blood, somatostatin (SS) and gastrin (GAS) level after continuous 15 days every day every.Result shows the 3 groups of rats taking in product of the present invention, the general symptom that it is insufficiency of the spleen is (withered by hair, tired crouching obviously is reduced addicted to saliva, activity, limbs fatigue, abdominal distention is obvious, just does or loose stool less, and crissum is filthy) be improved significantly, compare with model of spleen deficiency group and have significant difference (P < 0. 05, P < 0. 01).Physiochemical indice aspect, rat stomach therbligs (MTL) content has the trend of rising, but compared with model group nonsignificance; Rat stomach secretin (GAS) content significantly improves, and is 59.19 ± 6.93,58.36 ± 7.52, and 62.25 ± 7.11, significant difference (P <0. 05) is had compared with model group 46.02 ± 12.11; Rat plasma somatostatin (SS) content significantly rises, and is 96.28 ± 15.16,98.45 ± 14.15, and 101.02 ± 13.22, compare with model group 73.76 ± 16.98 and have significant difference (P < 0. 05).From upper data, product provided by the invention can obviously improve rat stomach intestinal function.
Claims (10)
1. a Chinese medicine composition, is made up of the raw material of following weight proportion: Radix Ginseng 3-15 part, Rhizoma Zingiberis 3-15 part, Cortex Cinnamomi 2-10 part, Pericarpium Citri tangerinae 7-35 part, Rhizoma Dioscoreae 3-15 part, Fructus Jujubae 5-25 part, Poria 1-20 part, Semen Lablab Album 1-60 part, Fructus Citri Sarcodactylis 1-20 part, Semen Raphani 1-10 part, black tea 1-120 part.
2. Chinese medicine composition according to claim 1, it is characterized by, be made up of the raw material of following weight proportion: Radix Ginseng 15 parts, Rhizoma Zingiberis 15 parts, Cortex Cinnamomi 10 parts, Pericarpium Citri tangerinae 35 parts, Rhizoma Dioscoreae 15 parts, 10 parts, Poria, Semen Lablab Album 30 parts, Fructus Citri Sarcodactylis 10 parts, Semen Raphani 5 parts, 25 parts, Fructus Jujubae and black tea 60 parts.
3. one kind comprises medicine or the health food of Chinese medicine composition described in claim 2, it is characterized by, described medicine or health food also comprise in following adjuvant or additive one or more: diluent, excipient, lubricant, disintegrating agent and correctives, and the dosage form of described medicine is granule, tablet, pill, powder, oral liquid or capsule.
4. one kind comprises the food of Chinese medicine composition described in claim 2, it is characterized by, described food also comprise in following adjuvant or additive one or more: acidity regulator, anticaking agents, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, colour fixative, enzyme preparation, flavour enhancer, nutrition enhancer, antiseptic, sweeting agent, thickening agent and spice, and described food comprises graininess or Powdered alternative tea, beverage, cake or confection.
5. the preparation method of medicine, health food or food according to claim 3 or 4, is characterized by, comprise the steps:
(1) described starting material with water or ethanol water are extracted, by extracting liquid filtering, concentrate;
(2) spraying dry, optionally adds adjuvant or additive, pelletizing forming, packaging sterilizing.
6. the preparation method of medicine, health food or food according to claim 5, it is characterized by: described step (1) is after described raw material is soaked 1 hour, heating extraction 1-4 time, each 1-2 hour, each amount of water is the 8-10 times amount of described raw material, by extracting solution merging, filtration, cold preservation, leave standstill, centrifugal removing impurity, concentrated.
7. the preparation method of medicine, health food or food according to claim 5, it is characterized by: described in state step (1) for after described raw material being added ethanol water and soaking 1 hour, heating extraction 1-4 time, each 1-2 hour, add the 5-7 times amount that ethanol water amount is described raw material at every turn, by extracting liquid filtering, merging, cold preservation, standing, filtration, reclaim ethanol, concentrated; Wherein, the concentration of described ethanol water is 70% (v/v).
8. the preparation method of medicine, health food or food according to claim 5, it is characterized by, described step (2) is the former powder obtained by spraying dry, add certain proportion brown sugar, white sugar, dextrin fine powder, its Central Plains powder and brown sugar ratio are 1:0-4, and former powder and white sugar ratio are 1:0-4, former powder and cyclodextrin ratios are 1:0.5-1.5, make granule, packaging, sterilizing.
9. the preparation method of food according to claim 4, is characterized by, comprise the steps:
(1) pulverize and sieve after the described raw material successively removal of impurity;
(2) optionally add adjuvant or additive, pack after packaging or soft bake, after sterilizing and get final product; Wherein said soft bake carries out at 80-150 DEG C.
10. the preparation method of food according to claim 4, is characterized by, comprise the steps:
(1) described starting material with water or ethanol water are extracted, by extracting liquid filtering, concentrate;
(2) add water and other adjuvants, mix homogeneously, cold preservation leaves standstill, and filters, adds beverage and commonly use correctives and other adjuvants, fine straining, fill, sterilizing.
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| CN105707314A (en) * | 2016-02-18 | 2016-06-29 | 上海中晋堂健康科技有限公司 | Body-warming tea plant drink |
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