CN103357058B - A kind of contact lens care solution and preparation method thereof - Google Patents
A kind of contact lens care solution and preparation method thereof Download PDFInfo
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- CN103357058B CN103357058B CN201210094867.9A CN201210094867A CN103357058B CN 103357058 B CN103357058 B CN 103357058B CN 201210094867 A CN201210094867 A CN 201210094867A CN 103357058 B CN103357058 B CN 103357058B
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- contact lens
- extract
- lens care
- care solution
- semen cassiae
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Abstract
The invention provides a kind of contact lens care solution, described contact lens care solution is the aqueous solution containing following component: pyrrolidone sodium carboxylate 0.1-0.5wt%; Vitamin B6 0.05-0.3wt%; Buffer agent 0.05-0.5wt%; Isoosmotic adjusting agent 0.6-0.95wt%; Semen Cassiae extract 0.05-0.2wt%; Flos Chrysanthemi extract 0.05-0.2wt%; Folium Menthae extract 0.05-0.2wt%; The pH value of described contact lens care solution is 6-8.Present invention also offers the preparation method of described contact lens care solution.Contact lens care solution provided by the invention, adopt natural bacteriostatic agent and pyrrolidone sodium carboxylate, it has good moistening effect and fungistatic effect, has no side effect to human non-toxic's evil.
Description
Technical field
The invention belongs to eye health field, be specifically related to a kind of contact lens care solution and preparation method thereof.
Background technology
At present contact lens care solution on the market mainly integrate sterilization, clean, flushing, the several functions such as maintenance product.Mostly containing the disinfectant such as hibitane, geramine composition in this contact lens care solution, there is certain injury to eyes.In addition, the moisture-keeping functions of existing contact lens care solution is inadequate, and eyeglass is easily dry, and oxygen transmission rate is low, easily produces the problems such as the dry and astringent discomfort of eyes, inflammation and red blood streak after user lenses fitted.
Summary of the invention
The invention solves contact lens care solution of the prior art to exist human body and poison side effect and the poor technical problem of anti-bacteria wet keeping effect.
The invention provides a kind of contact lens care solution, with the gross mass of described contact lens care solution for benchmark, described contact lens care solution is the aqueous solution containing following component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
Present invention also offers the preparation method of described contact lens care solution, comprise after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract are mixed in proportion and being dissolved in the water, adjust ph is 6-8, obtains described contact lens care solution.
Contact lens care solution provided by the invention, by adopting pyrrolidone sodium carboxylate as wetting agent, collocation simultaneously uses appropriate vitamin B6, can strengthen moistening effect, reduces ocular inflamation and occurs; In addition, by adopting the pure natural antibacterial containing Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract, human non-toxic's evil being had no side effect, also there is the effect of clearing away heat to improve acuity of vision, antiinflammatory, alleviation eyestrain, nutrition eyes simultaneously.The preparation method of contact lens care solution provided by the invention, technique is simple, easy to implement.
Detailed description of the invention
The invention provides a kind of contact lens care solution, with the gross mass of described contact lens care solution for benchmark, described contact lens care solution is the aqueous solution containing following component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
Contact lens care solution provided by the invention, by adopting pyrrolidone sodium carboxylate as wetting agent, collocation simultaneously uses appropriate vitamin B6, can strengthen moistening effect, reduces ocular inflamation and occurs; In addition, by adopting the pure natural antibacterial containing Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract, human non-toxic's evil being had no side effect, also there is the effect of clearing away heat to improve acuity of vision, antiinflammatory, alleviation eyestrain, nutrition eyes simultaneously.
In the present invention, described pyrrolidone sodium carboxylate is used as the wetting agent in contact lens care solution provided by the invention, the effect of its moisturizing lubrication; Its performance of keeping humidity is obviously better than polyvinylpyrrolidone of the prior art (PVP), pyrrolidone sodium carboxylate, polyvinyl alcohol (PVA), Polyethylene Glycol (PEG), hyaluronate sodium, poloxamer, glycerol or propylene glycol.
Owing to containing pyrrolidone sodium carboxylate in human skin keratinocyte's layer, for maintaining moisture of skin balance, skin is made to keep moist and elasticity, therefore pyrrolidone sodium carboxylate is called as natural wetting agent, and its moistening effect is far better than various wetting agents common in the prior aries such as glycerol, propylene glycol, sorbitol.In addition, the present inventor finds, the viscosity of pyrrolidone sodium carboxylate, also lower than various wetting agent of the prior art, do not have glycerol sticky thick and heavy, and safety is high, to skin, eye mucosa nonirritant.
Under preferable case, with the gross mass of described contact lens care solution for benchmark, the content of pyrrolidone sodium carboxylate is 0.2-0.4wt%.
Vitamin B6 can promote the ability that hyperplasia and material generate, and promotes DNA synthesis, improves immunity, reduce the generation of ocular inflamation, simultaneously can nutrition ocular nerve, enhances metabolism.In the present invention, vitamin B6 and pyrrolidone sodium carboxylate with the use of, moisture-keeping efficacy can be strengthened further.
Contact lens care solution provided by the invention is neutral conditioning liquid.Particularly, the pH value of described contact lens care solution is 6-8.Under preferable case, the pH value of described contact lens care solution is 6.5-7.5.In the present invention, the pH value of contact lens care solution adopts various pH adjusting agents conventional in prior art to regulate.Such as, described pH adjusting agent is selected from hydrochloric acid and/or sodium hydroxide, but is not limited to this.
In the present invention, the pH value that described buffer agent is used for guarantee system is 6-8, and larger fluctuation does not occur.Described buffer agent can adopt various buffer agents conventional in prior art, such as can be selected from boric acid, sodium borate, sodium hydrogen phosphate, sodium dihydrogen phosphate, disodiumedetate, sodium bicarbonate or Tris (Tris) one or more, but be not limited to this.In the present invention, described buffer agent preferably adopts Tris (Tris), makes the pH of conditioning liquid be more suitable for ocular environment, thus avoids the stimulation to eyes and injury.Under preferable case, with the gross mass of described contact lens care solution for benchmark, the content of buffer agent is 0.05-0.3wt%, and the content of isoosmotic adjusting agent is 0.8-0.95wt%.
Contact lens care solution will have the osmotic pressure of similar human tears, therefore passes through in the present invention to adopt isoosmotic adjusting agent, thus regulates the osmotic pressure of described contact lens care solution to be 250-350osmol/Kg.Described isoosmotic adjusting agent can adopt various isoosmotic adjusting agent conventional in prior art, such as, can be selected from one or more in sodium chloride, potassium chloride, calcium chloride or magnesium chloride.Under preferable case, described isoosmotic adjusting agent is sodium chloride, thus simulation human body tear component, ensure that conditioning liquid reaches minimum to eye irritation.
In the present invention, the antibacterial adopted in described contact lens care solution is natural bacteriostatic agent, is specially the mixture of Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract.
Semen Cassiae is the mature seed of leguminous plant Semen Cassiae, and its main component is anthraquinone compounds, and the element also containing naphtho--pyranone, multiple fatty acid, sterol, aminoacid, sugar and needed by human, the traditional Chinese medical science thinks that Semen Cassiae has effect of liver heat removing and eyesight improving.By adopting Semen Cassiae extract as antibacterial in the present invention, it contains anthraquinone analog compound, is main antipathogenic composition, has inhibitory action to most of antibacterial, can the biosynthesis of anti-bacteria amplifying nucleic acid and respiratory and produce antibacterial activity, improve Abwehrkraft des Koepers.
In the present invention, the extracting method of described Semen Cassiae extract can adopt various method of the prior art.Such as, take aqueous solution as solvent, at certain pressure, time, temperature, water logging extraction is carried out to Semen Cassiae, namely obtain cassia seed water extract.Or, take ethanol as solvent, soak with ethanol extraction carried out to Semen Cassiae, namely obtain Semen Cassiae ethanol extract.In addition, supercritical fluid (such as CO can also be adopted
2) as solvent, supercritical extraction is carried out to Semen Cassiae, thus obtain Semen Cassiae supercritical extract.The mode that microwave can also be adopted to be combined with ultrasound wave is extracted, and can improve the content of extraction efficiency and extract.
Adopt different extracting method, the effective ingredient in the extract obtained can be slightly different.In the present invention, the concrete extracting method of Semen Cassiae extract is not particularly limited, adopts various extracting method of the prior art all can realize the present invention.
Flos Chrysanthemi is exactly the common medicine for the treatment of ophthalmic since ancient times, and the traditional Chinese medical science thinks Flos Chrysanthemi energy dispelling pathogenic wind for improving eyesight, separates evanescence of heat dry, dizziness and red eyes.Containing monoterpene, chromocor compound, aminoacid in Flos Chrysanthemi extract, there is antibacterial, antivirus action, all have inhibitory action to gram positive bacteria, multiple pathogenic bacillus, can also capillary permeability be suppressed, play the effect of inflammation-inhibiting.
In the present invention, the extracting method of Flos Chrysanthemi extract can adopt various methods conventional in prior art.Similarly, water logging such as can be adopted to extract, thus obtain chrysanthemum water extract; Or, adopt soak with ethanol to obtain Flos Chrysanthemi ethanol extract; Also supercritical fluid (such as CO can be adopted
2) extract, thus obtain Flos Chrysanthemi supercritical extract.
Containing Peppermint essential oil in Folium Menthae extract, there is peat-reek, there is refrigerant convergence, refreshment of having one's ideas straightened out, the effect of relieving eye strain, antiinflammatory, elimination furuncle can be played.Meanwhile, the distinctive pungent sense of Herba Menthae and cool feeling can stimulate peripheral nerve, cause blood capillary to shrink to reflexive, thus reach antiinflammatory, pain relieving, antipruritic effect.Similarly, in the present invention, the extracting method of Folium Menthae extract also can adopt various methods conventional in prior art.Such as, water logging can be adopted to extract, thus obtain aqua methnae extract; Or, adopt soak with ethanol to obtain menthol extract; Also supercritical fluid (such as CO can be adopted
2) extract, thus obtain Herba Menthae supercritical extract.
Present invention also offers the preparation method of described contact lens care solution, comprise after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract are mixed in proportion and being dissolved in the water, adjust ph is 6-8, obtains described contact lens care solution.
The preparation method of contact lens care solution provided by the invention, only need be dispersed in water by each component, the then pH value of regulation system, ensure that osmotic pressure is 250-350osmol/Kg, can carry out disinfection after the assay was approved, subpackage.The preparation method of contact lens care solution provided by the invention, technique is simple, easy to implement.
In order to make technical problem solved by the invention, technical scheme and beneficial effect clearly understand, below in conjunction with embodiment, the present invention is further elaborated.In embodiment and comparative example adopt raw material to be all commercially available.
Embodiment 1-3
In the ratio shown in table 1 by each component mix homogeneously, then formation solution soluble in water, adds hydrochloric acid, sodium hydroxide regulation system pH value is 6-8, and detection osmotic pressure is 300osmol/Kg, obtains the contact lens care solution S1-S3 of embodiment 1-3.Weight percent content is in table 1.
Comparative example 1-3
Adopt the step identical with embodiment 1-3 to prepare contact lens care solution sample DS1-DS3, difference is that each component proportion is as shown in table 1.
Table 1
。
Performance test:
Randomly draw 40 people and try the contact lens soaked through S1-S3 and DS1-DS3 on, examination wearer experiences as shown in table 2.
Adopt method disclosed in GB19192-2003 to carry out antibacterial test to S1-S3 and DS1-DS3, test its fungistatic effect to staphylococcus aureus, escherichia coli, green pus bacterium and Candida albicans, be qualifiedly designated as OK, otherwise be NG.Test result is as shown in table 2.
Table 2
。
As can be seen from the test result of upper table 1, contact lens care solution provided by the invention has good performance of keeping humidity and bacteriostasis property.
As can be seen from the results contrast of S1-S3 and DS1, the present invention adopts pyrrolidone sodium carboxylate as wetting agent, and simultaneously with the use of vitamin B6, moistening effect obviously strengthens.
As can be seen from the results contrast of S1-S3 and DS2-DS3, the present invention adopts natural bacteriostatic agent, and have no side effect to human non-toxic's evil, under guarantee has the prerequisite of good moisturizing and fungistatic effect, can alleviate eyestrain, nutrition eyes, the wearer that has a try feels comfortable.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1. a contact lens care solution, is characterized in that, with the gross mass of described contact lens care solution for benchmark, described contact lens care solution is the aqueous solution containing following component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
2. contact lens care solution according to claim 1, is characterized in that, with the gross mass of described contact lens care solution for benchmark, the content of pyrrolidone sodium carboxylate is 0.2-0.4wt%.
3. contact lens care solution according to claim 1, is characterized in that, with the gross mass of described contact lens care solution for benchmark, the content of buffer agent is 0.05-0.3wt%, and the content of isoosmotic adjusting agent is 0.8-0.95wt%.
4. the contact lens care solution according to claim 1 or 3, it is characterized in that, described buffer agent be selected from boric acid, sodium borate, sodium hydrogen phosphate, sodium dihydrogen phosphate, disodiumedetate, sodium bicarbonate or Tris one or more; Described isoosmotic adjusting agent be selected from sodium chloride, potassium chloride, calcium chloride or magnesium chloride one or more.
5. contact lens care solution according to claim 4, is characterized in that, described buffer agent is Tris, and described isoosmotic adjusting agent is sodium chloride.
6. contact lens care solution according to claim 1, is characterized in that, the pH value of described contact lens care solution is 6.5-7.5.
7. the contact lens care solution according to claim 1 or 6, is characterized in that, the pH value of described contact lens care solution adopts pH adjusting agent to regulate, and described pH adjusting agent is selected from hydrochloric acid and/or sodium hydroxide.
8. contact lens care solution according to claim 1, is characterized in that, containing anthraquinone compounds in described Semen Cassiae extract; Described Semen Cassiae extract is cassia seed water extract, Semen Cassiae ethanol extract or Semen Cassiae supercritical extract.
9. contact lens care solution according to claim 1, is characterized in that, containing monoterpene, chromocor compound, aminoacid in described Flos Chrysanthemi extract; Described Flos Chrysanthemi extract is chrysanthemum water extract, Flos Chrysanthemi ethanol extract or Flos Chrysanthemi supercritical extract.
10. contact lens care solution according to claim 1, is characterized in that, containing Peppermint essential oil in described Folium Menthae extract; Described Folium Menthae extract is aqua methnae extract, menthol extract or Herba Menthae supercritical extract.
The preparation method of 11. contact lens care solutions according to claim 1, it is characterized in that, comprise after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract are mixed in proportion and being dissolved in the water, adjust ph is 6-8, obtains described contact lens care solution.
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| CN201210094867.9A CN103357058B (en) | 2012-04-01 | 2012-04-01 | A kind of contact lens care solution and preparation method thereof |
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| CN103357058B true CN103357058B (en) | 2015-09-30 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105296214A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Preparation method of contact lens cleaning solution |
| CN105296213A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Contact lens cleaning solution |
| CN106635462A (en) * | 2016-12-14 | 2017-05-10 | 成都锦汇科技有限公司 | Cleaning fluid for glasses |
| CN106692180B (en) * | 2016-12-22 | 2019-09-10 | 珠海博纳百润生物科技有限公司 | A kind of decontamination solution and preparation method thereof in emergency circumstances eye chemical burn |
| CN106955369A (en) * | 2017-05-22 | 2017-07-18 | 陶圣香 | A kind of preparation method of contact lens care solution |
| CN108522547A (en) * | 2018-05-25 | 2018-09-14 | 合肥昂诺新材料有限公司 | A kind of antibacterial conditioning liquid composition and its application |
| CN110819464B (en) * | 2019-10-11 | 2020-12-08 | 陕西仁康药业有限公司 | Hard corneal contact lens care solution and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574537A (en) * | 2009-06-01 | 2009-11-11 | 海昌隐形眼镜有限公司 | Composition for contact lens solution containing peppermint and preparation method thereof |
| CN101790694A (en) * | 2007-08-31 | 2010-07-28 | 诺瓦提斯公司 | Contact lens products |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101790694A (en) * | 2007-08-31 | 2010-07-28 | 诺瓦提斯公司 | Contact lens products |
| CN101574537A (en) * | 2009-06-01 | 2009-11-11 | 海昌隐形眼镜有限公司 | Composition for contact lens solution containing peppermint and preparation method thereof |
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