CN103316202B

CN103316202B - Preparation method of oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis

Info

Publication number: CN103316202B
Application number: CN201310220684.1A
Authority: CN
Inventors: 高真理
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-06-05
Filing date: 2013-06-05
Publication date: 2015-01-28
Anticipated expiration: 2033-06-05
Also published as: CN103316202A

Abstract

The invention relates to a preparation method of an oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis. The invention belongs to the field of traditional Chinese medicine preparation. The medicine is prepared from entireleaf dragonhead herb, blushred isodon herb, common phellinus fungus, ginkgo leaf, small centipeda herb, cottonrose hibiscus leaf, common ducksmeat herb, stir-fried xanthium sibiricum, Asiatic pennywort herb, Manchurian wildginger herb, Chinese ephedra herb, Szechwan lovage rhizome, biod magnolia flower bud, centipede, pearl powder, honey-suckle flower, calcined yellow croaker's auricular bone, tatarinow sweetflag rhizome, nidus verspae, clove, golden thread, dried toads venom, tonkin sophora root, blackberry lily, franchet groundcherry calyx or fruit, phoenix coat, angelica archang lica, black cicada slough, puff-ball, wild mythic fungus, musk, cow-bezoar, pig bile with wrinkled gianthyssop herb, Zhejiang fritillaria cirrhosa, abnormal Chinese honeylocust fruit, tin powder, ice boron powder, and frost on dried persimmon. The oral-dissolving sustained-release traditional Chinese medicine provided by the invention can be dissolved in mouth, and can be used for relieving nasopharyngitis. During the dissolving process, with melting and sustained-release of aromatic medicines, fumigation and fusion effects are provided for nasal hollow cavities. The oral dissolving time is longer than existing medicines, and a treatment effect is substantial.

Description

A kind of preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis

Technical field

Treat a preparation method for the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis, belong to field of traditional Chinese.

Background technology

Nasopharyngitis is a kind of common frdquently encountered disease, particularly air pollution, haze and influenza time, nasopharyngitis is usually mass-sended.Common sympton: nasal obstruction, rhinorrhea with clear discharge or turbid tears, even pus and blood; Dry pharynx, pharynx pain.Acute stage, nasopharynx part had burning sensation.Treatment thoroughly can not turn chronic nasopharyngitis.Nasal obstruction, watery nasal discharge; Often feel pharyngeal discomfort, pharynx foreign body sensation, time have dry cough.Acute stage nose, pharyngeal mucosa is congested, red and swollen.Nose has aqueous or purulent secretion.Chronic phase, is nasopharynx part mucous hyperemia not only; Also have pharyngeal lymphadenosis, mucomembranous surface has stiff secretions; Mucosa can have drying, atrophy, dry crusts.Nasal cavity checks: the swelling of concha nasalis inferior mucosa, hyperemia take on a red color or kermesinus.The course of disease is of a specified duration, not easily cures.Some is Seasonal Incidence, affects the sleep that normally learns, works and have a rest, even causes headache, hypomnesis.The cause of disease: how because patient's Abwehrkraft des Koepers is poor, failure of defensive QI to protect the body against pathogen, first wind and cold or wind heat and foul smell exopathogen invade the door of lung---caused by nasopharynx.Initial stage is evil in edema caused by disorder of QI, stops up and holds back lung key.Of a specified duration enters blood system by edema caused by disorder of QI, because of the stagnation of QI hyperamization stasis of blood; Or QI and blood is corrupt and pus and blood is excessive.Sickness rate is high according to the literature, and child's morbidity is higher.

Nasopharyngitis is not that simple rhinitis adds pharyngitis, but due to cavum nasopharyngeum is subject to virus, the invasion of antibacterial causes afterwards inflammation.Especially chronic nasopharyngitis, is difficult to cure, easily seasonal recurrence.And the existing oral change medicine that contains melts comparatively fast under the effect of saliva of buccal cavity, melting time is short, and active ingredient enters esophagus fast, cannot play the object of topical treatment, can only as adjuvant therapy medicaments.

Summary of the invention

The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, and provide a kind of preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis, this holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time is long, effectively can treat nasopharyngitis by holding in the mouth for dissolving drug.

The technical solution adopted for the present invention to solve the technical problems is: the holding in the mouth for dissolving drug slow release Chinese medicine of this treatment nasopharyngitis, it is characterized in that being made up of the raw material of following weight portion: Herba Dracocephali Integrifolii 27 ~ 33 parts, Rabdosia rubescens 25 ~ 30 parts, Phellinus igniarius (L. ex Fr.) Quel. 18 ~ 22 parts, Folium Ginkgo 18 ~ 22 parts, Herba Centipedae 9 ~ 11 parts, Folium Hibisci Mutabilis 9 ~ 11 parts, 9 ~ 11 parts, Herba Spirodelae, fry Herba Xanthii 9 ~ 11 parts, Herba Centellae 18 ~ 22 parts, Herba Asari 4.5 ~ 5.5 parts, 8 ~ 10 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 ~ 10 parts, Flos Magnoliae 9 ~ 11 parts, Scolopendra 4.5 ~ 5.5 parts, Margarita powder 5.5 ~ 7 parts, Flos Lonicerae 9 ~ 11 parts, forge Asteriscus Pseudosciaenae 9 ~ 11 parts, Rhizoma Acori Graminei 9 ~ 11 parts, Nidus Vespae 9 ~ 11 parts, Flos Caryophylli 5.5 ~ 7 parts, Rhizoma Coptidis 8 ~ 10 parts, Venenum Bufonis 1.2 ~ 1.8 parts, Radix Sophorae Tonkinensis 8 ~ 10 parts, Rhizoma Belamcandae 8 ~ 10 parts, Calyx Seu Fructus Physalis 13.5 ~ 18 parts, Membrana Follicularis ovi 5.5 ~ 7 parts, the Radix Angelicae Dahuricae 8 ~ 10 parts, Periostracum Cicadae 8 ~ 10 parts, Lasiosphaera Seu Calvatia 9 ~ 11 parts, wild Ganoderma 13.5 ~ 18 parts, 1.5 ~ 2.4 parts, Moschus, Calculus Bovis 1.5 ~ 2.4 parts, Fel Sus domestica mixes Herba Pogostemonis 8 ~ 10 parts, Bulbus Fritillariae Thunbergii 9 ~ 11 parts, gleditsia officinalis 8 ~ 10 parts, XILEI SAN 9 ~ 11 parts, BINGPENG SAN 9 ~ 11 parts, Mannosum Kaki 18 ~ 22 parts.

Preferably, be made up of the raw material of following weight portion: Herba Dracocephali Integrifolii 29 ~ 31 parts, Rabdosia rubescens 26 ~ 29 parts, Phellinus igniarius (L. ex Fr.) Quel. 19 ~ 21 parts, Folium Ginkgo 19 ~ 21 parts, Herba Centipedae 10 ~ 11 parts, Folium Hibisci Mutabilis 9 ~ 10 parts, 9 ~ 10 parts, Herba Spirodelae, fry Herba Xanthii 9 ~ 10 parts, Herba Centellae 20 ~ 21 parts, Herba Asari 5 ~ 5.5 parts, 8 ~ 9 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 ~ 9 parts, Flos Magnoliae 10 ~ 11 parts, Scolopendra 4.5 ~ 5 parts, Margarita powder 6 ~ 7 parts, Flos Lonicerae 9 ~ 10 parts, forge Asteriscus Pseudosciaenae 10 ~ 11 parts, Rhizoma Acori Graminei 9 ~ 10 parts, Nidus Vespae 9 ~ 10 parts, Flos Caryophylli 5.5 ~ 6 parts, Rhizoma Coptidis 8 ~ 9 parts, Venenum Bufonis 1.4 ~ 1.6 parts, Radix Sophorae Tonkinensis 8.5 ~ 9.5 parts, Rhizoma Belamcandae 8.5 ~ 9.5 parts, Calyx Seu Fructus Physalis 14 ~ 16 parts, Membrana Follicularis ovi 5.5 ~ 6.5 parts, the Radix Angelicae Dahuricae 9 ~ 10 parts, Periostracum Cicadae 9 ~ 10 parts, Lasiosphaera Seu Calvatia 9 ~ 11 parts, wild Ganoderma 13.5 ~ 18 parts, 1.9 ~ 2.2 parts, Moschus, Calculus Bovis 1.9 ~ 2.2 parts, Fel Sus domestica mixes Herba Pogostemonis 9 ~ 10 parts, Bulbus Fritillariae Thunbergii 9 ~ 10 parts, gleditsia officinalis 8.5 ~ 9.5 parts, XILEI SAN 9 ~ 10 parts, BINGPENG SAN 10 ~ 11 parts, Mannosum Kaki 19 ~ 21 parts.

Preferably, be made up of the raw material of following weight portion: Herba Dracocephali Integrifolii 30 parts, Rabdosia rubescens 27 parts, Phellinus igniarius (L. ex Fr.) Quel. 20 parts, Folium Ginkgo 20 parts, Herba Centipedae 10 parts, Folium Hibisci Mutabilis 10 parts, 10 parts, Herba Spirodelae, fry Herba Xanthii 10 parts, Herba Centellae 20 parts, Herba Asari 5 parts, 9 parts, Herba Ephedrae, Rhizoma Chuanxiong 9 parts, Flos Magnoliae 10 parts, Scolopendra 5 parts, Margarita powder 6 parts, Flos Lonicerae 10 parts, forge Asteriscus Pseudosciaenae 10 parts, Rhizoma Acori Graminei 10 parts, Nidus Vespae 10 parts, Flos Caryophylli 6, Rhizoma Coptidis 9, Venenum Bufonis 1.5 parts, Radix Sophorae Tonkinensis 9 parts, Rhizoma Belamcandae 9 parts, Calyx Seu Fructus Physalis 15 parts, Membrana Follicularis ovi 6 parts, the Radix Angelicae Dahuricae 9 parts, Periostracum Cicadae 9 parts, Lasiosphaera Seu Calvatia 10 parts, wild Ganoderma 15 parts, 2 parts, Moschus, Calculus Bovis 2, Fel Sus domestica mixes Herba Pogostemonis 9 parts, Bulbus Fritillariae Thunbergii 10 parts, gleditsia officinalis 9 parts, XILEI SAN 10 parts, BINGPENG SAN 10 parts, Mannosum Kaki 20 parts.Herba Dracocephali Integrifolii preferred Xinjiang Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and Herba Pogostemonis 1:1 mixing immersion in mass ratio in Herba Pogostemonis, is dried acquisition.

A kind of preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention, is characterized in that, adopts following steps:

1) by weight by Herba Dracocephali Integrifolii, Rabdosia rubescens, Phellinus igniarius (L. ex Fr.) Quel., Folium Ginkgo, Herba Centipedae, Folium Hibisci Mutabilis, Herba Spirodelae, fry Herba Xanthii, Herba Centellae, Herba Asari, Herba Ephedrae, Rhizoma Chuanxiong, Flos Magnoliae, Scolopendra, Flos Lonicerae, Rhizoma Acori Graminei, Nidus Vespae, Flos Caryophylli, Rhizoma Coptidis, Venenum Bufonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Calyx Seu Fructus Physalis, Membrana Follicularis ovi, the Radix Angelicae Dahuricae, Periostracum Cicadae, Lasiosphaera Seu Calvatia, wild Ganoderma, Calculus Bovis, Fel Sus domestica mixes Herba Pogostemonis, Bulbus Fritillariae Thunbergii, gleditsia officinalis, carry out pulverizing after XILEI SAN mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, the coarse powder and the water that residue are accounted for Chinese medicine powder gross mass 4/5ths boil 1:5 ~ 7 in mass ratio, filter cleaner, obtain concentrated solution,

2) concentrated solution is mixed with the fine powder accounting for Chinese medicine powder gross mass 1/5th in step 1) mix thoroughly, dry at 60 ~ 70 DEG C, obtain concentrated traditional Chinese medicine;

3) by concentrated traditional Chinese medicine and Moschus, BINGPENG SAN, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixing, pulverized 1000 ~ 2000 mesh sieves and obtain super fine;

4) refined honey is heated, when temperature reaches 110 ~ 115 DEG C, adds Cera Flava, then according to super fine be 1:1 ~ 1.5 containing the refined honey mass ratio of 5 ~ 8% Cera Flavas, slowly put into super fine, stir and be 3 ~ 5 grams of pills.In step 4), Cera Flava consumption accounts for 5 ~ 8% of refined honey quality.The preferred refine Cera Flava of Cera Flava.

In step 4), Cera Flava consumption accounts for 5 ~ 8% of refined honey quality.

Described refined honey is that Mel is heated to 119 ~ 122 DEG C, has goods during larger rufous bubble.Selected Mel needs without impurity such as offscum, dead honeybees.The refined honey water content obtained according to above method is less than 4%, and viscosity is strong, and the white silk of appearance of two finger sth. made by twisting, becomes well-defined bulk in instillation cold water.Mel makes refined honey after refining, and object is the impurity removed wherein, evaporation section moisture, destroys ferment, kills microorganism, strengthens bonding force.

The pharmacological property of each compatibe drug adopted in the present invention is as follows:

Herba Dracocephali Integrifolii, bitter, temperature, function cures mainly, and cough-relieving, eliminates the phlegm, relievings asthma.Cough, phlegm dyspnea can be treated.Herba Dracocephali Integrifolii have antiinflammatory, diastole bronchial smooth muscle, antioxidation, antiviral, antibacterial, improve the characteristic such as immunity.Usually in order to treat tracheitis, cough that bronchitis, allergic rhinitis, chronic pharyngitis, postnasal drip symptom (PNDS), EB, cough variant asthma (CVA) cause or expectoration or wheezing symptoms.As chronic obstructive pulmonary disease (COPD) and the control chronic airway inflammation of bronchial asthma disease and the first-line treatment medication of lax airway smooth muscle.

Rabdosia rubescens, bitter in the mouth; Sweet; Cold nature, heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Cure mainly laryngopharynx swelling and pain; Headache due to common cold; Tracheitis; Chronic hepatitis; Rheumatic arthritis; Snake bite and insect sting.Containing rubescensine A in Rabdosia rubescens, there is excellent anticancer, antitumor, the effect of antibacterial, parasite killing, can heat-clearing and toxic substances removing, anti-inflammatory analgetic, stomach invigorating invigorate blood circulation again

Herba Ephedrae, pungent, micro-hardship, temperature, returns lung, urinary bladder channel; Effect: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Herba ephedrae inclined profit warm in nature, pungent loose perspiration relaxes, and enhances the merit of nourishing the lung to arrest cough, wins with depressed lung-energy dispersing cough-relieving power.Separating for showing disease, asthma and cough, suppressing irritated tramsmitter release.

Folium Ginkgo: bitter, puckery, property is put down, mild toxicity.Gui Jing: the heart, lung, spleen channel.Function: invigorate blood circulation and nourish heart, astringing intestine to stop diarrhea of astringing the lung.Cure mainly: obstruction of qi in the chest and cardialgia; To breath with cough phlegmatic cough; Dysentery.

Phellinus igniarius (L. ex Fr.) Quel., micro-hardship, cold.Function cures mainly: sharp the five internal organs, softening the hard mass, toxin expelling, and hemostasis, invigorates blood circulation, stomach function regulating antidiarrheal.Cure mainly gonorrhea, bleeding not during menses, lump in the abdomen, hypochondrium fluid retention, diarrhea due to hypofunction of the spleen.Phellinus igniarius (L. ex Fr.) Quel. energy reinforced immunological power, anticancer, alleviating pain; Liver protection effect; Reduce and adjustment blood sugar concentration, effectively prevent and improve diabetes.Reduce blood fat, prevent arteriosclerosis, prevent the generation of cardiovascular and cerebrovascular disease.Prevention and therapy rheumatoid arthritis.Phellinus linteus extract can suppress uric acid completely, has good result to gout.Antiallergic, fine to allergic rhinitis, cureless eczema curative effect.

Herba Asari, returns lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel; Effect: induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention, sensible; Cure mainly: exterior syndrome due to wind-cold, headache, toothache, rheumatic arthralgia, phlegm retention cough with asthma, nasal obstruction, nasal sinusitis, aphtha, separately has antiinflammatory, immunosuppressant, local anesthesia effect.

Flos Magnoliae, pungent, temperature.Enter lung, stomach warp.Dispel the wind, sensible.Control headache, nasal sinusitis, have a stuffy nose obstructed, toothache.There is antiallergic, have and shrink nasal mucosa blood vessel, local convergence effect.

The Radix Angelicae Dahuricae, pungent, temperature. entering lung, spleen, stomach warp, is Yangming Channel guiding drug; Effect: induce sweat cold expelling, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis; Cure mainly: headache, supraorbital bone pain, toothache, nasal sinusitis, skin pruritus due to dryness.

Rhizoma Chuanxiong, acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel; Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping; .

Folium Hibisci Mutabilis, pungent, micro-hardship, cool, return lung, Liver Channel; Effect: clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling.

Asteriscus Pseudosciaenae is salty, flat; Effect: dispel the wind, sensible, fossil, treating stranguria, antiinflammatory; Cure mainly: otitis media, rhinitis, sinusitis with purulent discharge, nasal sinusitis is treated in removing toxic substances, controls Ting discharging ear, the inducing decomposition of calculi, treating stranguria, and headache, nasal sinusitis, has a stuffy nose obstructed, toothache.

Herba Xanthii, pungent, bitter, temperature, returns lung meridian; Effect: loose wind dehumidifying clearing the nasal passage; Wind and heat eliminating, removing toxic substances parasite killing.Control wind syndrome of head, dizzy, arthralgia chiefly caused by damp pathogen contracture, conjunctival congestion, corneal nebula, wind leprosy, furuncle swells, pathopyretic ulcer, skin pruritus.

Herba Centipedae, pungent, temperature, returns lung meridian; Effect: dispersing wind-cold, clearing the nasal passage, cough-relieving, removing toxic substances; Cure mainly: flu, headache, nasal sinusitis, nasal polyp, cough, sore throat, deaf, conjunctivitis, rheumatic arthralgia, traumatic injury, toxic swelling, scabies.

Margarita powder is sweet, salty, cold.GUIXIN, Liver Channel.Function cures mainly: arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances, promoting tissue regeneration and ulcer healing.

Periostracum Cicadae, sweet, cold, return lung, Liver Channel; Effect: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic, antiallergic, alleviate chronic inflammation, improves microcirculation.

Herba Spirodelae, acrid in the mouth, cold, enter lung meridian; Effect: diaphoresis, dispels the wind, row water, heat clearing away, removing toxic substances.

Rhizoma Coptidis, bitter, cold, nontoxic, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Effect: heat clearing and damp drying, eliminating fire and detoxication.

Lasiosphaera Seu Calvatia, pungent, flat, nontoxic, enter lung meridian; Effect: removing heat from the lung and relieving sorethroat, hemostasis and anti-inflammation; Cure mainly: antibacterial, antiinflammatory, cough-relieving.

Gleditsia officinalis, Xin Xian, temperature, slightly poisonous.Enter lung, stomach, large intestine channel; Effect: removing heat from the lung and relieving sorethroat, hemostasis and anti-inflammation; Eliminate the phlegm have one's ideas straightened out, mass dissipating and swelling eliminating.

Bulbus Fritillariae Thunbergii, the large hardship of taste, cold in nature, lunar, few sun of starting with, bright, the moon of fainting of foot sun; Effect: removing heat-phlegm, powder detoxifcation.

Fel Sus domestica mixes Herba Pogostemonis, and Fel Sus domestica bitter in the mouth is salty, cold.Enter liver, gallbladder, lung, the heart, large intestine channel; Expectorant cough suppressant and anti-asthmatic, lung benefiting, spleen reinforcing, moisturizes.Herba Pogostemonis, acrid in the mouth; Slightly warm in nature.Return lung; Spleen; Stomach warp; Effect: dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.

Venenum Bufonis, pungent, temperature; Poisonous.GUIXIN warp.Function cures mainly: removing toxic substances, pain relieving, refreshment of having one's ideas straightened out.For carbuncle furuncle, laryngopharynx swelling and pain, heatstroke coma, stomachache is vomited and diarrhoea.

Rhizoma Acori Graminei, pungent, bitter, temperature.GUIXIN, stomach warp; Effect: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; Regulate the flow of vital energy, invigorate blood circulation, loose wind.

Flos Caryophylli, sweet in the mouth is pungent, extremely hot in nature.Enter stomach kidney two warp; Effect: warming the stomach, the kidney warming; Antifungal, antiulcer, antiviral, antioxidation.

Radix Sophorae Tonkinensis is bitter, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.Pent up for fire-toxin, laryngopharynx swelling and pain, gingivitis.

Moschus, property is pungent, warm, nontoxic, bitter in the mouth, enters the heart, spleen, Liver Channel; Effect: have one's ideas straightened out, ward off dirty, dredging collateral, dissipating blood stasis.

Wild Ganoderma, sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma, warming the lung for resolving phlegm, relieving cough and asthma, often can control phlegm retention syndrome; Can delayed hypersensitivity be suppressed, strengthen immunologic function.

Calyx Seu Fructus Physalis is bitter, cold.Return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, and sore-throat relieving reduces phlegm, diuresis.For pharyngalgia hoarseness, phlegm-heat cough, dysuria; External treatment pemphigus, eczema.

Membrana Follicularis ovi, sweet, temperature.Function cures mainly: tonifying the lung and stopping cough.For chronic tracheitis, chronic cough, night sweat.Herba Centellae, bitter, acrid, cold, returns liver,spleen,kidney warp; Effect: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.

Cera Flava, sweet in the mouth, light, property is put down, and returns spleen, stomach, large intestine channel; Effect: removing toxic substances, granulation promoting, hemostasis, analgesic therapy.

XILEI SAN, consists of: Dens Elephatis, Uroctea compatilis Koch. charcoal, Concha, Borax, Indigo Naturalis, Margarita powder, Calculus Bovis; Function: effect: removing toxic substances removing the necrotic tissue and promoting granulation, treatment due to intestine erosion and ulcer, has antiulcer, autoimmunity depression effect.

BINGPENG SAN, consists of: Borneolum Syntheticum, Borax (forging), Cinnabaris (cinnabar), Matrii Sulfas Exsiccatus (Natrii Sulfas is obtained through air slaking drying, main contains sodium sulfate).

Mannosum Kaki, sweet, cool.Function cures mainly: secretion replenishing and throat moistening, nourishing the lung to arrest cough.For aphtha, throat pain, dry pharynx is coughed.

Side of the present invention separates:

The holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention adopts organizes drug combination more, cooperatively interacts between medicine group and group, and collaborative promotion, improves overall drug effect.

Fry Herba Xanthii, Flos Magnoliae, the Radix Angelicae Dahuricae, Periostracum Cicadae, Herba Spirodelae, Herba Asari, Herba Ephedrae, Rhizoma Chuanxiong dispelling wind to relieve the exterior syndrome, can cold-dispelling, wind heat headache, to control under nasal obstruction, watery nasal discharge, nasal sinusitis tears incessantly, anosmia; Add Rhizoma Atractylodis, Herba Pogostemonis, Herba Menthae, removing dampness by means of aromatics, dispel turbid sensible; Rhizoma Coptidis, Herba Centellae, Folium Hibisci Mutabilis, Lasiosphaera Seu Calvatia, Flos Lonicerae, Indigo Naturalis (XILEI SAN contains), Fel Sus domestica, liver heat removing function of gallbladder promoting, damp eliminating is induced sweat, pathogenic fire reducing is subsided a swelling, Nidus Vespae, Scolopendra, Dens Elephatis (XILEI SAN contains), Concha (XILEI SAN contains), Venenum Bufonis, Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, eliminating stagnation blood stasis dispelling, except polyp, the meridian dredging, removing the necrotic tissue and promoting granulation; Bulbus Fritillariae Thunbergii, Flos Caryophylli, Margarita powder reduce phlegm, eliminating stagnation, dredging collateral, blood stasis dispelling, Flos Caryophylli, Margarita powder antiulcer, antiinflammatory antiviral, removing toxic substances and promoting granulation; Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Calyx Seu Fructus Physalis throat, wild Ganoderma, Periostracum Cicadae, Radix Saposhnikoviae, Membrana Follicularis ovi have effect of antiallergic.Borneolum Syntheticum (BINGPENG SAN containing), Moschus, gleditsia officinalis, Rhizoma Acori Graminei, Borax (BINGPENG SAN containing) causing resuscitation with aromatic drugs, Moschus pass through 12 warps, and add Borneolum Syntheticum and also can promote drug absorption, Borax detoxifies anticorrosion; Moschus, Borneolum Syntheticum can accelerate drug absorption speed.Oral cavity and nose, pharyngeally to communicate, mucosa is connected.Chinese medicine Moschus, Borneolum Syntheticum, Flos Magnoliae can fumigate nasal cavity, nasopharynx part and play awakening consciousness effect when holding in the mouth for dissolving drug.

Moschus, Borneolum Syntheticum fragrance are walked to alter, and having one's ideas straightened out, it is dirty to ward off; Clear away heart-fire detoxifies; Margarita, tranquillization with heavy prescription.All medicines share, and have the merit of warding off dirty removing toxic substances and having one's ideas straightened out, and Calculus Bovis, Margarita powder, Borneolum Syntheticum, Borax medical instrument have the merit of fragrance, heat radiation, removing toxic substances, so can control pharyngalgia aphtha, wind heat is hidden from view.

Nasopharyngitis is not that simple rhinitis adds pharyngitis, but due to cavum nasopharyngeum is subject to virus, the invasion of antibacterial causes afterwards inflammation.Herba Dracocephali Integrifolii, bitter in the mouth, warm in nature.Have eliminate the phlegm, cough-relieving, the function of relievining asthma.Folium Ginkgo enters lung meridian, can treat asthma, alleviates irritated, and Mannosum Kaki can secretion replenishing and throat moistening, profit cardiopulmonary, Calyx Seu Fructus Physalis Anhydroalkannin, antibacterial, antiviral, immunity moderation system.Herba Dracocephali Integrifolii is main, is aided with Folium Ginkgo, Mannosum Kaki and Calyx Seu Fructus Physalis, can strengthen the relieving cough and asthma of Herba Dracocephali Integrifolii, antiinflammatory, antibacterial effect, has good therapeutic effect for by virus, bacterial nasopharyngitis.

Phellinus igniarius (L. ex Fr.) Quel. can stop blooding, invigorate blood circulation, and Membrana Follicularis ovi can repair mucosal tissue, and being rich in asiaticoside in Herba Centellae can promote wound healing, and Herba Spirodelae is pungent coolly delivers, line water detumescence.Phellinus igniarius (L. ex Fr.) Quel., Membrana Follicularis ovi, Herba Centellae, Herba Spirodelae coupling can be accelerated to repair nose and pharyngeal impaired mucosa, removing the necrotic tissue, more wound, granulation promoting while treatment.

Cinnabaris (BINGPENG SAN contains), Bulbus Fritillariae Thunbergii and Venenum Bufonis coupling can reduce the stimulation of Venenum Bufonis toxicity to pharyngeal mucosa, collaborative enhancing is relievingd asthma, the effect of antitussive, antiinflammatory, the analgesia anaesthetic effect of Venenum Bufonis, can alleviate again pharyngalgia that nasopharyngitis brings, rhinocnesmus, headache, reduction of patient is uncomfortable.

The ephedrine contained in Herba Ephedrae can relax bronchial smooth muscle, vasoconstrictive, alleviates and prevention of asthma, and the effect of simultaneously treating nasal decongestion and nasal obstruction is fast and lasting.Folium Ginkgo has excellent antiallergic and antiasthmatic effect.Herba Ephedrae, Semen Ginkgo coupling can alleviate the nasal obstruction and nasal decongestion that allergic rhinitis brings, and have effect of Prevention asthma, also relieve chronic nasopharyngitis mucosa chronic congestion, the dry cough pain brought can have foreign body sensation, dyspneic symptom simultaneously.

The holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention adopts Mel and Cera Flava to do binding agent, has good adhesiveness and sustained release rate.With the erodible framework material (also known as make wax lipid skeleton) of natural Cera Flava as oral cavity holding in the mouth for dissolving drug pill.Due to the slow releasing thereupon of dissolved substance gradually of Cera Flava, by the restriction of temperature, the such fast softening of honeyed pill can not be caused to dissolve and rinsed by saliva, swallow.But slowly lasting lasting molten release thing, reduce the rinse capability of saliva to medicament.Increase, extend the treatment time of medicine.

Taking in process in holding in the mouth for dissolving drug process, under the effect along with the temperature in oral cavity, saliva, Cera Flava, Mel, the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention heats up gradually, and slowly melts.Because oral cavity and nasal cavity communicate, can along with the thawing slow release of fragrant medicine in holding in the mouth for dissolving drug process, to the cavity of nasal cavity have stifling, change the effect of melting.

The preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, in step 1), Chinese medicine powder crosses 100 mesh sieves, sifts out the fine powder accounting for Chinese medicine powder gross mass 1/5th, and the absorption of fine powder is better, gives over to subsequent step 2) and step 3) in make super fine; Residue is accounted for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, obtains concentrated solution, and object is the effective ingredient of medical material of purifying further.

Concentrated solution is as step 2) in water-phase component mix with the fine powder accounting for Chinese medicine powder gross mass 1/5th.Reason is that concentrated solution Chinese medicine effective ingredient dissolution velocity in water is very fast, adopts concentrated solution to mix the dissolution velocity that can slow down active ingredient with fine powder.The fine powder consumption accounting for Chinese medicine powder gross mass 1/5th can ensure the pill volume suitable size holding in the mouth for dissolving drug made, and pill dissolution velocity is comparatively slow simultaneously, and drug effect is better.Fine powder as filling, Cera Flava has viscosity as binding agent as the erodible skeleton of pill, refined honey.

By concentrated traditional Chinese medicine and Moschus in step 3), BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixing, reason is Moschus, BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki temperature more than 60 DEG C after can cause harmful effect to drug effect, therefore can not in step 2) in directly mix with concentrated solution.Pulverized 1000 ~ 2000 mesh sieves in step 3) and obtain super fine, 1000 ~ 2000 order super fines can so that mucosa delivery, and it is convenient to absorb;

In step 4), refined honey is heated, temperature adds Cera Flava when reaching 110 ~ 115 DEG C, then slowly putting into super fine, at higher temperature, the dispersibility of Cera Flava in pill can be improved by adding Cera Flava, make the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention have dissolution velocity comparatively stably.

A kind of usage for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention, is characterized in that: adopt oral holding in the mouth for dissolving drug, be grown up one time 3 ~ 5 grams, 4 times on the one; Or, with hot Oleum sesami, pill is ground out furnishing ointment, dips balm daubing nasal cavity by swab stick; Or, after grinding of pill, and boiled water pill in mass ratio: water=1:1 ~ 15 are diluted, and carry out coloclysis.

Compared with prior art, the beneficial effect that the preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention has is:

1, the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is rapid-action and have no side effect.By mucosa delivery, directly act on oral cavity, periodontal, pharynx, throat membranes play local directly targeted therapy effect.Rapid-action, liver can be avoided to be subject to the Degradation of effect and gastrointestinal.About 200CM oral mucosa area, has abundant blood vessel to absorb the drug and directly enters blood circulation, because mucosa is thinner than skin, higher than skin permeability 4 ~ 400 times, is more easily penetrated by medicine and is absorbed.Oral mucosa is stronger than nasa tolerance property, not easy damaged.By oral cavity and hypoglossis mucous membrane directly absorb directly enter body circulation safer, effective;

2, the holding in the mouth for dissolving drug slow release traditional Chinese medicine slow-releasing excellent effect for the treatment of nasopharyngitis of the present invention, Mel and Cera Flava is adopted to do binding agent, Cera Flava is again as the erodible framework material of oral cavity holding in the mouth for dissolving drug pill, make that the effective ingredient in pill dissolves gradually, slow releasing, solve existing honeyed pill, the softening dissolving of buccal tablets fast, the problem of easily rinsed by saliva, swallowing.The holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time for the treatment of nasopharyngitis of the present invention is long, and the holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time of 3 ~ 5 grams for the treatment of nasopharyngitises of the present invention is 50 ~ 60 minutes, the holding in the mouth for dissolving drug time be existing honeyed pill, 1 ~ 2 times of the buccal tablets holding in the mouth for dissolving drug time;

3, the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention can dispel the wind lung qi dispersing, clearing away heat and expelling pathogen in the exterior, and antiallergic dehumidifies, brain is protected in liver heat removing, and having one's ideas straightened out, it is turbid to drive, removing the necrotic tissue and promoting granulation, to treatment acute nasopharyngitis and chronic nasopharyngitis's excellent effect, totall effective rate in clinical treatment 93%, cure rate 87%." method of external treatment and the reason for the treatment of by oral administration of medicines " external treatment can be capable with Nei Zhi And, mends the too late for the treatment of by oral administration of medicines, not only for nasopharyngitis, also can treat acute rhinitis, chronic rhinitis, allergic rhinitis, sinusitis, acute, chronic pharyngitis.Both can remove nasal obstruction after patient once adds medicine to, improve ventilation.After pharyngeal medication for several times, itching throat, dry pharynx alleviate.Convenient for children medication; Medicine is good, amount less, cost is low.Reduce medical expense, improve curative effect, mouthfeel is suitable for, and should be accepted by patient;

4, the preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, can improve the drug effect of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, the slow-release time of prolong drug;

5, the usage of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is easy to operate, and stopping treatment can take out at any time.And have and, when patient is not easy to holding in the mouth for dissolving drug administration, the mode of nasal-cavity administration and coloclysis administration can be adopted to treat.During nasal-cavity administration, hot Oleum sesami is selected pill to be ground out furnishing balm daubing at nasal cavity, Oleum sesami contains abundant vitamin E and linoleic acid, the active ingredient of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is dissolved in Oleum sesami, be easier to by Nasal Mucosa Absorption, Oleum sesami has good moisturizing effect simultaneously, can moisten dry nasal cavity.

Detailed description of the invention

Embodiment 1 ~ 6 is specific embodiments of the preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, and wherein embodiment 3 is preferred forms.

embodiment 1

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 31 parts, Rabdosia rubescens 25 parts, Phellinus igniarius (L. ex Fr.) Quel. 21 parts, Folium Ginkgo 19 parts, Herba Centipedae 11 parts, Folium Hibisci Mutabilis 9 parts, 9.5 parts, Herba Spirodelae, fry Herba Xanthii 9 parts, Herba Centellae 21 parts, Herba Asari 5.5 parts, 8 parts, Herba Ephedrae, Rhizoma Chuanxiong 8.5 parts, Flos Magnoliae 11 parts, Scolopendra 4.5 parts, Margarita powder 7 parts, Flos Lonicerae 9 parts, forge Asteriscus Pseudosciaenae 11 parts, Rhizoma Acori Graminei 9 parts, Nidus Vespae 9 parts, Flos Caryophylli 5.5 parts, Rhizoma Coptidis 8 parts, Venenum Bufonis 1.5 parts, Radix Sophorae Tonkinensis 9 parts, Rhizoma Belamcandae 9 parts, Calyx Seu Fructus Physalis 15 parts, Membrana Follicularis ovi 6 parts, the Radix Angelicae Dahuricae 9 parts, Periostracum Cicadae 9 parts, Lasiosphaera Seu Calvatia 10 parts, wild Ganoderma 15 parts, Calculus Bovis 1.5, Fel Sus domestica mixes Herba Pogostemonis 8 parts, Bulbus Fritillariae Thunbergii 10 parts, gleditsia officinalis 9 parts, XILEI SAN 10 parts, carry out pulverizing after Mannosum Kaki 20 parts mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, residue is accounted for coarse powder and the water 1:5 soak by water in mass ratio of Chinese medicine powder gross mass 4/5ths, filter cleaner, obtain concentrated solution,

2) concentrated solution is mixed with the fine powder accounting for Chinese medicine powder gross mass 1/5th in step 1) mix thoroughly, 60 ~ 65 DEG C of oven dry, obtain concentrated traditional Chinese medicine;

3) by concentrated traditional Chinese medicine and 2.2 parts, Moschus, BINGPENG SAN 10 parts, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixing, pulverized 1000 ~ 2000 mesh sieves and obtain super fine;

4) refined honey is heated, when temperature reaches 110 ~ 115 DEG C, adds the Cera Flava accounting for refined honey quality 5 ~ 8%, then according to super fine be the addition of 1:1 ~ 1.5 containing the refined honey mass ratio of 5 ~ 8% Cera Flavas, slowly put into super fine, stir and be 3 ~ 5 grams of pills.

Herba Dracocephali Integrifolii preferred Xinjiang Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and Herba Pogostemonis 1:1 mixing immersion in mass ratio in Herba Pogostemonis, is dried acquisition.Cera Flava is yellow beeswax.

embodiment 2

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 29 parts, Rabdosia rubescens 30 parts, Phellinus igniarius (L. ex Fr.) Quel. 20 parts, Folium Ginkgo 21 parts, Herba Centipedae 10.5 parts, Folium Hibisci Mutabilis 10 parts, 9 parts, Herba Spirodelae, fry Herba Xanthii 9.5 parts, Herba Centellae 20.5 parts, Herba Asari 5 parts, 8.5 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 parts, Flos Magnoliae 10 parts, Scolopendra 5 parts, Margarita powder 6 parts, Flos Lonicerae 10 parts, forge Asteriscus Pseudosciaenae 11 parts, Rhizoma Acori Graminei 9.5 parts, Nidus Vespae 9.5 parts, Flos Caryophylli 6, Rhizoma Coptidis 9, Venenum Bufonis 1.5 parts, Radix Sophorae Tonkinensis 9 parts, Rhizoma Belamcandae 9 parts, Calyx Seu Fructus Physalis 15 parts, Membrana Follicularis ovi 6 parts, the Radix Angelicae Dahuricae 9 parts, Periostracum Cicadae 9 parts, Lasiosphaera Seu Calvatia 10 parts, wild Ganoderma 15 parts, Calculus Bovis 2, Fel Sus domestica mixes Herba Pogostemonis 9 parts, Bulbus Fritillariae Thunbergii 10 parts, gleditsia officinalis 9 parts, XILEI SAN 10 parts, carry out pulverizing after Mannosum Kaki 20 parts mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, residue is accounted for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, obtain concentrated solution,

3) by concentrated traditional Chinese medicine and 2 parts, Moschus, BINGPENG SAN 10 parts, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixing, pulverized 1000 ~ 2000 mesh sieves and obtain super fine;

Herba Dracocephali Integrifolii preferred Xinjiang Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and Herba Pogostemonis 1:1 mixing immersion in mass ratio in Herba Pogostemonis, is dried acquisition.Cera Flava is refine Cera Flava.

embodiment 3

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 30 parts, Rabdosia rubescens 27 parts, Phellinus igniarius (L. ex Fr.) Quel. 20 parts, Folium Ginkgo 20 parts, Herba Centipedae 10 parts, Folium Hibisci Mutabilis 10 parts, 10 parts, Herba Spirodelae, fry Herba Xanthii 10 parts, Herba Centellae 20 parts, Herba Asari 5 parts, 9 parts, Herba Ephedrae, Rhizoma Chuanxiong 9 parts, Flos Magnoliae 10 parts, Scolopendra 5 parts, Margarita powder 6 parts, Flos Lonicerae 10 parts, forge Asteriscus Pseudosciaenae 10 parts, Rhizoma Acori Graminei 10 parts, Nidus Vespae 10 parts, Flos Caryophylli 6, Rhizoma Coptidis 9, Venenum Bufonis 1.5 parts, Radix Sophorae Tonkinensis 9 parts, Rhizoma Belamcandae 9 parts, Calyx Seu Fructus Physalis 15 parts, Membrana Follicularis ovi 6 parts, the Radix Angelicae Dahuricae 9 parts, Periostracum Cicadae 9 parts, Lasiosphaera Seu Calvatia 10 parts, wild Ganoderma 15 parts, Calculus Bovis 2, Fel Sus domestica mixes Herba Pogostemonis 9 parts, Bulbus Fritillariae Thunbergii 10 parts, gleditsia officinalis 9 parts, XILEI SAN 10 parts, carry out pulverizing after Mannosum Kaki 20 parts mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, residue is accounted for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, obtain concentrated solution,

Herba Dracocephali Integrifolii preferred Xinjiang Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and Herba Pogostemonis 1:1 mixing immersion in mass ratio in Herba Pogostemonis, is preferably dried acquisition in the winter time.Cera Flava is cera alba.

embodiment 4

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 33 parts, Rabdosia rubescens 26 parts, Phellinus igniarius (L. ex Fr.) Quel. 22 parts, Folium Ginkgo 18 parts, Herba Centipedae 9 parts, Folium Hibisci Mutabilis 9 parts, 11 parts, Herba Spirodelae, fry Herba Xanthii 9 parts, Herba Centellae 22 parts, Herba Asari 5.5 parts, 10 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 parts, Flos Magnoliae 9 parts, Scolopendra 5.5 parts, Margarita powder 7 parts, Flos Lonicerae 10 parts, forge Asteriscus Pseudosciaenae 10 parts, Rhizoma Acori Graminei 10 parts, Nidus Vespae 10 parts, Flos Caryophylli 6, Rhizoma Coptidis 9, Venenum Bufonis 1.5 parts, Radix Sophorae Tonkinensis 9 parts, Rhizoma Belamcandae 9 parts, Calyx Seu Fructus Physalis 15 parts, Membrana Follicularis ovi 7 parts, the Radix Angelicae Dahuricae 8 parts, Periostracum Cicadae 10 parts, Lasiosphaera Seu Calvatia 11 parts, wild Ganoderma 15 parts, Calculus Bovis 2, Fel Sus domestica mixes Herba Pogostemonis 9 parts, Bulbus Fritillariae Thunbergii 10 parts, gleditsia officinalis 9 parts, XILEI SAN 10 parts, Mannosum Kaki 20 carries out pulverizing and obtains Chinese medicine powder after mixing, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, residue is accounted for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, obtain concentrated solution,

Herba Dracocephali Integrifolii preferred Xinjiang Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and Herba Pogostemonis 1:1 mixing immersion in mass ratio in Herba Pogostemonis, is dried acquisition.Cera Flava is cera alba.

embodiment 5

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 27 parts, Rabdosia rubescens 28 parts, Phellinus igniarius (L. ex Fr.) Quel. 22 parts, Folium Ginkgo 18 ~ 22 parts, Herba Centipedae 9 ~ 11 parts, Folium Hibisci Mutabilis 11 parts, 9 parts, Herba Spirodelae, fry Herba Xanthii 9 parts, Herba Centellae 22 parts, Herba Asari 5.5 parts, 10 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 parts, Flos Magnoliae 9 parts, Scolopendra 4.5 parts, Margarita powder 7 parts, Flos Lonicerae 11 parts, forge Asteriscus Pseudosciaenae 9 parts, Rhizoma Acori Graminei 11 parts, Nidus Vespae 9 parts, Flos Caryophylli 5.5 parts, Rhizoma Coptidis 8 parts, Venenum Bufonis 1.8 parts, Radix Sophorae Tonkinensis 8 parts, Rhizoma Belamcandae 10 parts, Calyx Seu Fructus Physalis 13.5 parts, Membrana Follicularis ovi 7 parts, the Radix Angelicae Dahuricae 8 parts, Periostracum Cicadae 8 parts, Lasiosphaera Seu Calvatia 9 parts, wild Ganoderma 13.5 parts, 1.5 parts, Moschus, Calculus Bovis 2.4 parts, Fel Sus domestica mixes Herba Pogostemonis 8 parts, Bulbus Fritillariae Thunbergii 9 parts, gleditsia officinalis 10 parts, XILEI SAN 11 parts, BINGPENG SAN 9 parts, Mannosum Kaki 18 parts

Carry out pulverizing after mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, coarse powder residue being accounted for Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, acquisition concentrated solution;

embodiment 6

Preparation method is as follows:

1) by weight by Herba Dracocephali Integrifolii 33 parts, Rabdosia rubescens 29 parts, Phellinus igniarius (L. ex Fr.) Quel. 18 parts, Folium Ginkgo 22 parts, Herba Centipedae 9 parts, Folium Hibisci Mutabilis 9 parts, 11 parts, Herba Spirodelae, fry Herba Xanthii 11 parts, Herba Centellae 18 parts, Herba Asari 4.5 parts, 8 parts, Herba Ephedrae, Rhizoma Chuanxiong 10 parts, Flos Magnoliae 11 parts, Scolopendra 5.5 parts, Margarita powder 5.5 parts, Flos Lonicerae 9 parts, forge Asteriscus Pseudosciaenae 11 parts, Rhizoma Acori Graminei 9 parts, Nidus Vespae 11 parts, Flos Caryophylli 7 parts, Rhizoma Coptidis 10 parts, Venenum Bufonis 1.2 parts, Radix Sophorae Tonkinensis 8 parts, Rhizoma Belamcandae 10 parts, Calyx Seu Fructus Physalis 18 parts, Membrana Follicularis ovi 5.5 parts, the Radix Angelicae Dahuricae 8 parts, Periostracum Cicadae 10 parts, Lasiosphaera Seu Calvatia 11 parts, wild Ganoderma 18 parts, 1.5 parts, Moschus, Calculus Bovis 2.4 parts, Fel Sus domestica mixes Herba Pogostemonis 8 parts, Bulbus Fritillariae Thunbergii 11 parts, gleditsia officinalis 10 parts, XILEI SAN 9 parts, BINGPENG SAN 11 parts, carry out pulverizing after Mannosum Kaki 22 parts mixing and obtain Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder accounting for Chinese medicine powder gross mass 1/5th, residue is accounted for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner, obtain concentrated solution,

Clinical practice of the present invention is summarized as follows:

Chronic nasopharyngitis.

Nasopharynx part is dry congested or red and swollen, there is secretions, examination of nasopharynx is shown in mucosa chronic congestion, hypertrophy is plump, coated with secretions or dry crusts, hoarseness, pharyngalgia, headache, dizziness, weak, clear (pus) nasal mucus of nasal obstruction, sneeze, stream, nasopharynx part are itched, dry cough pain has foreign body sensation, dyspnea, dizzy headache, weak, hyposmia, hypomnesis.During viral infection, leukocyte count is normal or on the low side, and percentage of lymphocyte raises.During bacterial infection, leukocyte count increasing proportion and shift to left phenomenon, neutrophilic granulocyte increasing proportion and shift to left phenomenon.Nasopharynx is dry uncomfortable, has the not easily expectoration of thickness sample secretions, therefore patient coughs frequently normal with feeling sick.Severe patient has hoarseness, pharyngalgia, headache, dizziness, weak, whole body or the local symptom such as dyspepsia, low grade fever.

Acute nasopharyngitis.

Be under full nasopharynx part mucosa, mucosa and adenoid acute inflammation, mainly betide pharyngeal tonsil.Nasal obstruction, watery nasal discharge, headache and nasopharynx part do pain, burning sensation, foreign body sensation.Examination of nasopharynx is shown in mucosa acute congestion edema, and has volume mucopurulent secretion thing to adhere to, and secretions can be dirty along pharynx rear wall.

Allergic rhinitis.

Caused (as demodicid mite, pollen, animal scurf, fungus) by particular allergen.Every day is paroxysmal sneeze for several times, how to show effect at once after contact allergy is former; Thin nasal discharge, nasal obstruction, intranasal is itched, pale, the two Carapax et Plastrum Testudinis edema of sharp nasal mucosa, visible thin nasal discharge or glutinous tears at the bottom of meatus nasi communis and nose.

Sinusitis.

Nasal obstruction, pus tears, Head And Face distension and constriction, olfactory sensation changes.Nasal cavity checks: the congested swelling of nasal membrane, is obvious especially with places such as middle nasal concha, middle nasal meatus and olfactory clefts.The front group of visible middle nasal meatus's empyema of sinusitis, the scorching visible olfactory cleft empyema of posterior nasal sinuses, or pus flow to choana from top.

Chronic rhinitis.

Do during nasal obstruction, nasal mucus pus is thick to be increased, dizzy headache, olfactory disorder.Concha nasalis enlargement, in, concha nasalis inferior enlargement is common, middle nasal concha enlargement is then the vital sign of primary disease, the congested swelling of mucosa or mucosa flushing, and mucosa is light red, and place has stickiness or glutinous purulent secretion as seen at the bottom of middle nasal meatus, olfactory sulcus, nose etc.

Chronic pharyngitis

Pharyngeal discomfort, does, itches, swollen, and secretions is many and gradually have causalgia, easily feels sick, has foreign body sensation, and that coughs does not go out, and can not swallow, and lateral pharyngeal band is got involved, and has obvious otalgia.

Acute pharyngitis

Pharyngeal drying, scorching hot, swallow pain.Portion's mucous hyperemia swelling, in peony, secretions showed increased.With oropharynx lateral wall for work, the swelling of pharyngopalatine arch mucosa.The enlargement of pharynx rear wall lymph follicle, congested.Soft palate and tonsil are also congested.

A kind of usage for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention, is characterized in that: adopt oral holding in the mouth for dissolving drug, be grown up one time 3 ~ 5 grams, 4 times on the one; Continuous use 7 days is 1 course for the treatment of.Or when having a stuffy nose serious, with hot Oleum sesami, pill being ground out furnishing ointment, dipping balm daubing nasal cavity by swab stick.

Curative effect judging standard: curative effect is divided into healing according to the improvement situation of above-mentioned symptom, takes a turn for the better and do not heal, use in the course for the treatment of described in effective effect according to aforementioned disorders classification, total effective rate is cure rate and improvement rate sum.Add up after 2 ~ 3 courses for the treatment of of holding in the mouth for dissolving drug slow release Chinese medicine of continuous use treatment nasopharyngitis of the present invention, statistical result is as shown in table 1:

Table 1 is the case statistics for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis with the present invention

Always effective 3390 examples, recovery from illness 3185 example, takes in 2 ~ 3 courses for the treatment of, total effective rate 93%, cure rate 87%.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat a preparation method for the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis, it is characterized in that, adopt following steps:

4) heated by refined honey, add Cera Flava when temperature reaches 110 ~ 115 DEG C, Cera Flava consumption accounts for 5 ~ 8% of refined honey quality, then according to super fine be 1:1 ~ 1.5 containing the refined honey mass ratio of Cera Flava, slowly put into super fine, stir and be 3 ~ 5 grams of pills;

The raw materials used proportioning by following weight portion forms: Herba Dracocephali Integrifolii 27 ~ 33 parts, Rabdosia rubescens 25 ~ 30 parts, Phellinus igniarius (L. ex Fr.) Quel. 18 ~ 22 parts, Folium Ginkgo 18 ~ 22 parts, Herba Centipedae 9 ~ 11 parts, Folium Hibisci Mutabilis 9 ~ 11 parts, 9 ~ 11 parts, Herba Spirodelae, fry Herba Xanthii 9 ~ 11 parts, Herba Centellae 18 ~ 22 parts, Herba Asari 4.5 ~ 5.5 parts, 8 ~ 10 parts, Herba Ephedrae, Rhizoma Chuanxiong 8 ~ 10 parts, Flos Magnoliae 9 ~ 11 parts, Scolopendra 4.5 ~ 5.5 parts, Margarita powder 5.5 ~ 7 parts, Flos Lonicerae 9 ~ 11 parts, forge Asteriscus Pseudosciaenae 9 ~ 11 parts, Rhizoma Acori Graminei 9 ~ 11 parts, Nidus Vespae 9 ~ 11 parts, Flos Caryophylli 5.5 ~ 7 parts, Rhizoma Coptidis 8 ~ 10 parts, Venenum Bufonis 1.2 ~ 1.8 parts, Radix Sophorae Tonkinensis 8 ~ 10 parts, Rhizoma Belamcandae 8 ~ 10 parts, Calyx Seu Fructus Physalis 13.5 ~ 18 parts, Membrana Follicularis ovi 5.5 ~ 7 parts, the Radix Angelicae Dahuricae 8 ~ 10 parts, Periostracum Cicadae 8 ~ 10 parts, Lasiosphaera Seu Calvatia 9 ~ 11 parts, wild Ganoderma 13.5 ~ 18 parts, 1.5 ~ 2.4 parts, Moschus, Calculus Bovis 1.5 ~ 2.4 parts, Fel Sus domestica mixes Herba Pogostemonis 8 ~ 10 parts, Bulbus Fritillariae Thunbergii 9 ~ 11 parts, gleditsia officinalis 8 ~ 10 parts, XILEI SAN 9 ~ 11 parts, BINGPENG SAN 9 ~ 11 parts, Mannosum Kaki 18 ~ 22 parts.