CN103316202A - Oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis, and preparation method thereof - Google Patents
Oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis, and a preparation method thereof. The invention belongs to the field of traditional Chinese medicine preparation. The medicine is prepared from entireleaf dragonhead herb, blushred isodon herb, common phellinus fungus, ginkgo leaf, small centipeda herb, cottonrose hibiscus leaf, common ducksmeat herb, stir-fried xanthium sibiricum, Asiatic pennywort herb, Manchurian wildginger herb, Chinese ephedra herb, Szechwan lovage rhizome, biod magnolia flower bud, centipede, pearl powder, honey-suckle flower, calcined yellow croaker's auricular bone, tatarinow sweetflag rhizome, nidus verspae, clove, golden thread, dried toads venom, tonkin sophora root, blackberry lily, franchet groundcherry calyx or fruit, phoenix coat, angelica archang lica, black cicada slough, puff-ball, wild mythic fungus, musk, cow-bezoar, pig bile with wrinkled gianthyssop herb, Zhejiang fritillaria cirrhosa, abnormal Chinese honeylocust fruit, tin powder, ice boron powder, and frost on dried persimmon. The oral-dissolving sustained-release traditional Chinese medicine provided by the invention can be dissolved in mouth, and can be used for relieving nasopharyngitis. During the dissolving process, with melting and sustained-release of aromatic medicines, fumigation and fusion effects are provided for nasal hollow cavities. The oral dissolving time is longer than existing medicines, and a treatment effect is substantial.
Description
Technical field
A kind of holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis and preparation method thereof belongs to field of traditional Chinese.
Background technology
Nasopharyngitis is a kind of common frdquently encountered disease, and particularly when air pollution, haze and influenza, nasopharyngitis is usually mass-sended.Common sympton: nasal obstruction, rhinorrhea with clear discharge or turbid tears, even pus and blood; Dry pharynx, pharynx are ached.Acute stage,, nasopharynx part had burning sensation.Treatment thoroughly can not turn the chronic nasopharyngitis.Nasal obstruction, watery nasal discharge; Often feel pharyngeal discomfort, pharynx foreign body sensation, the time dry cough arranged.Acute stage,, nose, pharyngeal mucosa be congested, red and swollen.Nose has aqueous or purulent secretion.Chronic phase, is the nasopharynx part mucous hyperemia not only; Also have pharyngeal lymphadenosis, mucomembranous surface has stiff secretions; Mucosa can have drying, atrophy, dry crusts.Nasal cavity checks: the swelling of concha nasalis inferior mucosa, hyperemia takes on a red color or kermesinus.The course of disease is of a specified duration, is difficult for curing.Some is Seasonal Incidence, affects the sleep of normally learning, work and have a rest, even causes headache, hypomnesis.The cause of disease: how poor because of patient's Abwehrkraft des Koepers, failure of defensive QI to protect the body against pathogen, wind and cold or wind heat and foul smell exopathogen are at first invaded the door of lung---due to the nasopharynx.The initial stage heresy is stopped up and is held back the lung key at edema caused by disorder of QI.Of a specified duration enters blood system by edema caused by disorder of QI, because of the stagnation of QI hyperamization stasis of blood; Or QI and blood corruption and pus and blood is excessive.Sickness rate is high according to the literature, and child's morbidity is higher.
Nasopharyngitis is not that simple rhinitis adds pharyngitis, but because cavum nasopharyngeum is subject to the inflammation that the invasion of virus, antibacterial causes afterwards.Especially the chronic nasopharyngitis is difficult to cure, easily seasonal recurrence.And existing oral containing medicine melts under the effect of saliva of buccal cavity comparatively fast, and melting time is short, and active ingredient enters esophagus fast, can't play the purpose of topical treatment, can only be as adjuvant therapy medicaments.
Summary of the invention
The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis and preparation method thereof is provided, this holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time is long, can effectively treat nasopharyngitis by holding in the mouth for dissolving drug.
The technical solution adopted for the present invention to solve the technical problems is: the holding in the mouth for dissolving drug slow release Chinese medicine of this treatment nasopharyngitis; it is characterized in that being made by the raw material of following weight portion: 27 ~ 33 parts of Herba Dracocephali Integrifoliis; 25 ~ 30 parts of Rabdosia rubescens; 18 ~ 22 parts of Phellinus igniarius (L. ex Fr.) Quel.; 18 ~ 22 parts of Folium Ginkgos; 9 ~ 11 parts of Herba Centipedae; 9 ~ 11 parts of Folium Hibisci Mutabiliss; 9 ~ 11 parts in Herba Spirodelae; fry 9 ~ 11 parts of Herba Xanthiis, 18 ~ 22 parts of Herba Centellaes; 4.5 ~ 5.5 parts of Herba Asaris; 8 ~ 10 parts in Herba Ephedrae; 8 ~ 10 parts of Rhizoma Chuanxiongs; 9 ~ 11 parts of Flos Magnoliaes; 4.5 ~ 5.5 parts of Scolopendras; 5.5 ~ 7 parts of Margarita powder; 9 ~ 11 parts of Flos Loniceraes; forge 9 ~ 11 parts of Asteriscus Pseudosciaenaes; 9 ~ 11 parts of Rhizoma Acori Graminei; 9 ~ 11 parts of Nidus Vespaes; 5.5 ~ 7 parts of Flos Caryophyllis; 8 ~ 10 parts of Rhizoma Coptidis; 1.2 ~ 1.8 parts of Venenum Bufoniss; 8 ~ 10 parts of Radix Sophorae Tonkinensiss; 8 ~ 10 parts of Rhizoma Belamcandae; 13.5 ~ 18 parts of Calyx Seu Fructus Physaliss; 5.5 ~ 7 parts of Membrana Follicularis ovis; 8 ~ 10 parts of the Radixs Angelicae Dahuricae; 8 ~ 10 parts of Periostracum Cicadaes; 9 ~ 11 parts of Lasiosphaera Seu Calvatia; 13.5 ~ 18 parts of wild Ganodermas; 1.5 ~ 2.4 parts in Moschus; 1.5 ~ 2.4 parts of Calculus Boviss; Fel Sus domestica is mixed 8 ~ 10 parts of Herba Pogostemoniss; 9 ~ 11 parts of Bulbus Fritillariae Thunbergii; 8 ~ 10 parts of gleditsia officinalises; 9 ~ 11 parts of XILEI SAN; 9 ~ 11 parts of BINGPENG SAN; 18 ~ 22 parts of Mannosum Kakis.
Preferably; raw material by following weight portion is made: 29 ~ 31 parts of Herba Dracocephali Integrifoliis; 26 ~ 29 parts of Rabdosia rubescens; 19 ~ 21 parts of Phellinus igniarius (L. ex Fr.) Quel.; 19 ~ 21 parts of Folium Ginkgos; 10 ~ 11 parts of Herba Centipedae; 9 ~ 10 parts of Folium Hibisci Mutabiliss; 9 ~ 10 parts in Herba Spirodelae; fry 9 ~ 10 parts of Herba Xanthiis, 20 ~ 21 parts of Herba Centellaes; 5 ~ 5.5 parts of Herba Asaris; 8 ~ 9 parts in Herba Ephedrae; 8 ~ 9 parts of Rhizoma Chuanxiongs; 10 ~ 11 parts of Flos Magnoliaes; 4.5 ~ 5 parts of Scolopendras; 6 ~ 7 parts of Margarita powder; 9 ~ 10 parts of Flos Loniceraes; forge 10 ~ 11 parts of Asteriscus Pseudosciaenaes; 9 ~ 10 parts of Rhizoma Acori Graminei; 9 ~ 10 parts of Nidus Vespaes; 5.5 ~ 6 parts of Flos Caryophyllis; 8 ~ 9 parts of Rhizoma Coptidis; 1.4 ~ 1.6 parts of Venenum Bufoniss; 8.5 ~ 9.5 parts of Radix Sophorae Tonkinensiss; 8.5 ~ 9.5 parts of Rhizoma Belamcandae; 14 ~ 16 parts of Calyx Seu Fructus Physaliss; 5.5 ~ 6.5 parts of Membrana Follicularis ovis; 9 ~ 10 parts of the Radixs Angelicae Dahuricae; 9 ~ 10 parts of Periostracum Cicadaes; 9 ~ 11 parts of Lasiosphaera Seu Calvatia; 13.5 ~ 18 parts of wild Ganodermas; 1.9 ~ 2.2 parts in Moschus; 1.9 ~ 2.2 parts of Calculus Boviss; Fel Sus domestica is mixed 9 ~ 10 parts of Herba Pogostemoniss; 9 ~ 10 parts of Bulbus Fritillariae Thunbergii; 8.5 ~ 9.5 parts of gleditsia officinalises; 9 ~ 10 parts of XILEI SAN; 10 ~ 11 parts of BINGPENG SAN; 19 ~ 21 parts of Mannosum Kakis.
Preferably; raw material by following weight portion is made: 30 parts of Herba Dracocephali Integrifoliis; 27 parts of Rabdosia rubescens; 20 parts of Phellinus igniarius (L. ex Fr.) Quel.; 20 parts of Folium Ginkgos; 10 parts of Herba Centipedae; 10 parts of Folium Hibisci Mutabiliss; 10 parts in Herba Spirodelae; fry 10 parts of Herba Xanthiis; 20 parts of Herba Centellaes; 5 parts of Herba Asaris; 9 parts in Herba Ephedrae; 9 parts of Rhizoma Chuanxiongs; 10 parts of Flos Magnoliaes; 5 parts of Scolopendras; 6 parts of Margarita powder; 10 parts of Flos Loniceraes; forge 10 parts of Asteriscus Pseudosciaenaes; 10 parts of Rhizoma Acori Graminei; 10 parts of Nidus Vespaes; Flos Caryophylli 6; Rhizoma Coptidis 9; 1.5 parts of Venenum Bufoniss; 9 parts of Radix Sophorae Tonkinensiss; 9 parts of Rhizoma Belamcandae; 15 parts of Calyx Seu Fructus Physaliss; 6 parts of Membrana Follicularis ovis; 9 parts of the Radixs Angelicae Dahuricae; 9 parts of Periostracum Cicadaes; 10 parts of Lasiosphaera Seu Calvatia; 15 parts of wild Ganodermas; 2 parts in Moschus; Calculus Bovis 2; Fel Sus domestica is mixed 9 parts of Herba Pogostemoniss; 10 parts of Bulbus Fritillariae Thunbergii; 9 parts of gleditsia officinalises; 10 parts of XILEI SAN; 10 parts of BINGPENG SAN, 20 parts of Mannosum Kakis.The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.
A kind of preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention is characterized in that, adopts following steps:
1) by weight with Herba Dracocephali Integrifolii, Rabdosia rubescens, Phellinus igniarius (L. ex Fr.) Quel., Folium Ginkgo, Herba Centipedae, Folium Hibisci Mutabilis, Herba Spirodelae, fry Herba Xanthii, Herba Centellae, Herba Asari, Herba Ephedrae, Rhizoma Chuanxiong, Flos Magnoliae, Scolopendra, Flos Lonicerae, Rhizoma Acori Graminei, Nidus Vespae, Flos Caryophylli, Rhizoma Coptidis, Venenum Bufonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Calyx Seu Fructus Physalis, Membrana Follicularis ovi, the Radix Angelicae Dahuricae, Periostracum Cicadae, Lasiosphaera Seu Calvatia, wild Ganoderma, Calculus Bovis, Fel Sus domestica is mixed Herba Pogostemonis, Bulbus Fritillariae Thunbergii, gleditsia officinalis, XILEI SAN is pulverized the acquisition Chinese medicine powder after mixing, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, the coarse powder and the water that residue are accounted for Chinese medicine powder gross mass 4/5ths boil 1:5 ~ 7 in mass ratio, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and Moschus, BINGPENG SAN, Margarita powder are forged Asteriscus Pseudosciaenae, Mannosum Kaki mixing, pulverize 1000 ~ 2000 mesh sieves and obtain super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds Cera Flava, and be 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.The Cera Flava consumption accounts for 5 ~ 8% of refined honey quality in the step 4).The preferred refine Cera Flava of Cera Flava.
The Cera Flava consumption accounts for 5 ~ 8% of refined honey quality in the step 4).
Described refined honey is that Mel is heated to 119～122 ℃, the goods when having larger rufous bubble.Selected Mel needs without impurity such as offscum, dead honeybees.The refined honey water content that obtains according to above method is that viscosity is strong below 4%, and the white silk of the appearance of two finger sth. made by twisting splashes into the well-defined bulk of one-tenth in the cold water.Mel is made refined honey after refining, purpose is the impurity of removing wherein, and evaporation section moisture destroys ferment, and kill microorganisms strengthens bonding force.
The pharmacological property of each compatibe drug that adopts among the present invention is as follows:
Herba Dracocephali Integrifolii, hardship, temperature, function cures mainly, and cough-relieving, eliminates the phlegm, relievings asthma.Can treat cough, phlegm dyspnea.Herba Dracocephali Integrifolii have antiinflammatory, diastole bronchial smooth muscle, antioxidation, antiviral, antibiotic, improve the characteristic such as immunity.Cough or the expectoration or the symptom of panting that usually cause in order to treat drip syndrome (PNDS) behind tracheitis, bronchitis, allergic rhinitis, chronic pharyngitis, the nose, EB, cough variant asthma (CVA).As the control chronic airway inflammation of chronic obstructive pulmonary disease (COPD) and bronchial asthma disease and the first-line treatment medication of lax airway smooth muscle.
Rabdosia rubescens, bitter in the mouth; Sweet; Cold nature, heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Cure mainly laryngopharynx swelling and pain; Headache due to common cold; Tracheitis; Chronic hepatitis; Rheumatic arthritis; Snake bite and insect sting.Contain rubescensine A in the Rabdosia rubescens, have excellent anticancer, antitumor, the effect of antibiotic, parasite killing, but heat-clearing and toxic substances removing, anti-inflammatory analgetic, stomach invigorating are invigorated blood circulation again
Herba Ephedrae, hot, little hardship, temperature is returned lung, urinary bladder channel; Effect: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Honey Herba Ephedrae inclined to one side profit warm in nature, suffering are distributed the antiperspirant effect and are relaxed, and have strengthened the merit of nourishing the lung to arrest cough, win with depressed lung-energy dispersing cough-relieving power.Be used for table disease and separate, asthma and cough suppresses irritated mediator and discharges.
Folium Ginkgo: bitter, puckery, property is put down, mild toxicity.Gui Jing: the heart, lung, spleen channel.Function: invigorate blood circulation and nourish heart, the astringing intestine to stop diarrhea of astringing the lung.Cure mainly: obstruction of qi in the chest and cardialgia; The phlegmatic cough of breathing with cough; Dysentery.
Phellinus igniarius (L. ex Fr.) Quel., little hardship, cold.Function cures mainly: sharp the five internal organs, and softening the hard mass, toxin expelling, stomach function regulating antidiarrheal is invigorated blood circulation in hemostasis.Cure mainly gonorrhea, bleeding not during menses, lump in the abdomen, hypochondrium fluid retention, diarrhea due to hypofunction of the spleen.Phellinus igniarius (L. ex Fr.) Quel. energy reinforced immunological power, anticancer, alleviating pain; Liver protection effect; Reduce and adjust blood sugar concentration, effectively prevent and improve diabetes.Blood fat reducing prevents arteriosclerosis, prevents the generation of cardiovascular and cerebrovascular disease.Prevention and treatment rheumatoid arthritis.Phellinus linteus extract can suppress uric acid fully, and gout is had good result.Antiallergic, fine to allergic rhinitis, cureless eczema curative effect.
Herba Asari is returned lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel; Effect: cold expelling induces sweat; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention, sensible; Cure mainly: exterior syndrome due to wind-cold, headache, toothache, rheumatic arthralgia, the phlegm retention cough with asthma, nasal obstruction, nasal sinusitis, aphtha, other has antiinflammatory, immunosuppressant, local anesthesia effect.
Flos Magnoliae, suffering, temperature.Enter lung, stomach warp.Dispel the wind, sensible.Control headache, nasal sinusitis is had a stuffy nose obstructed toothache.Antiallergic is arranged, the nasal mucosa of contraction blood vessel, local convergence effect are arranged.
The Radix Angelicae Dahuricae, suffering, temperature. enter lung, spleen, stomach warp, be the Yangming Channel guiding drug; Effect: the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis; Cure mainly: headache, supraorbital bone pain, toothache, nasal sinusitis, skin pruritus due to dryness.
Rhizoma Chuanxiong, acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel; Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping;
Folium Hibisci Mutabilis, suffering, little hardship, lung is returned in cold, Liver Channel; Effect: clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling.
Asteriscus Pseudosciaenae is salty, flat; Effect: dispel the wind, sensible, fossil, treating stranguria, antiinflammatory; Cure mainly: otitis media, rhinitis, sinusitis with purulent discharge, nasal sinusitis is treated in detoxifcation, controls the Ting discharging ear, and the inducing decomposition of calculi is treating stranguria, headache, nasal sinusitis is had a stuffy nose obstructed toothache.
Herba Xanthii, hot, bitter, temperature is returned lung meridian; Effect: loose wind dehumidifying clearing the nasal passage; Wind and heat eliminating, the detoxifcation parasite killing.Control wind syndrome of head, dizziness, the arthralgia chiefly caused by damp pathogen contracture, conjunctival congestion, corneal nebula, the wind leprosy, furuncle is swollen, pathopyretic ulcer, skin pruritus.
Herba Centipedae, suffering, temperature is returned lung meridian; Effect: dispersing wind-cold, clearing the nasal passage, cough-relieving, detoxifcation; Cure mainly: flu, headache, nasal sinusitis, nasal polyp, cough, sore throat, deafness, conjunctivitis, rheumatic arthralgia, traumatic injury, toxic swelling, scabies.
Margarita powder, sweet, salty, cold.GUIXIN, Liver Channel.Function cures mainly: the arresting convulsion of calming the nerves, the removing nebula that makes eye bright, detoxifcation, promoting tissue regeneration and ulcer healing.
Periostracum Cicadae, sweet, cold, return lung, Liver Channel; Effect: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic, antiallergic, alleviate chronic inflammation is improved microcirculation.
Herba Spirodelae, acrid in the mouth, cold, enter lung meridian; Effect: diaphoresis, dispel the wind row water, heat clearing away, detoxifcation.
Rhizoma Coptidis, hardship, cold, nontoxic, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Effect: heat clearing and damp drying, eliminating fire and detoxication.
Lasiosphaera Seu Calvatia, hot, flat, nontoxic, enter lung meridian; Effect: removing heat from the lung and relieving sorethroat, hemostasis and anti-inflammation; Cure mainly: antibiotic, antiinflammatory, cough-relieving.
Gleditsia officinalis, hot salty, temperature, slightly poisonous.Enter lung, stomach, large intestine channel; Effect: removing heat from the lung and relieving sorethroat, hemostasis and anti-inflammation; Eliminate the phlegm have one's ideas straightened out, mass dissipating and swelling eliminating.
Bulbus Fritillariae Thunbergii, flavor is large bitter, cold in nature, lunar, few sun of starting with, bright, the moon of fainting of foot sun; Effect: removing heat-phlegm, powder detoxifcation.
Fel Sus domestica is mixed Herba Pogostemonis, and the Fel Sus domestica bitter in the mouth is salty, cold.Enter liver, gallbladder, lung, the heart, large intestine channel; Expectorant cough suppressant and anti-asthmatic, lung benefiting, spleen reinforcing is moisturized.Herba Pogostemonis, acrid in the mouth; Slightly warm in nature.Return lung; Spleen; The stomach warp; Effect: dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.
Venenum Bufonis, suffering, temperature; Poisonous.The GUIXIN warp.Function cures mainly: detoxifcation, pain relieving, the refreshment of having one's ideas straightened out.Be used for the carbuncle furuncle, laryngopharynx swelling and pain, the heatstroke coma, stomachache is vomited and diarrhoea.
Rhizoma Acori Graminei, hot, bitter, temperature.GUIXIN, stomach warp; Effect: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; Regulate the flow of vital energy, invigorate blood circulation, loose wind.
Flos Caryophylli, sweet in the mouth is hot, extremely hot in nature.Enter stomach kidney two warps; Effect: warming the stomach, the kidney warming; Antifungal, antiulcer, antiviral, antioxidation.
Radix Sophorae Tonkinensis, hardship, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.Be used for fire-toxin and pent up laryngopharynx swelling and pain, gingivitis.
Moschus, property is hot, warm, nontoxic, bitter in the mouth, enters the heart, spleen, Liver Channel; Effect: have one's ideas straightened out, ward off dirty, collateral dredging, dissipating blood stasis.
Wild Ganoderma, sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly: invigorating QI and tranquilization, relieving cough and asthma.Be used for dizzy sleeplessness, shortness of breath and palpitation, the asthenia cough with asthma, warming the lung for resolving phlegm, relieving cough and asthma often can be controlled phlegm retention syndrome; Can suppress delayed hypersensitivity, strengthen immunologic function.
Calyx Seu Fructus Physalis, hardship, cold.Return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, sore-throat relieving reduces phlegm, diuresis.Be used for the pharyngalgia hoarseness, phlegm-heat cough, dysuria; The external treatment pemphigus, eczema.
Membrana Follicularis ovi, sweet, temperature.Function cures mainly: tonifying the lung and stopping cough.Be used for chronic tracheitis, chronic cough, night sweat.Herba Centellae, bitter, hot, cold, return the liver,spleen,kidney warp; Effect: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.
Cera Flava, sweet in the mouth, light, property is flat, returns spleen, stomach, large intestine channel; Effect: detoxifcation, granulation promoting, hemostasis, analgesic therapy.
XILEI SAN consists of: Dens Elephatis, Uroctea compatilis Koch. charcoal, Concha, Borax, Indigo Naturalis, Margarita powder, Calculus Bovis; Function: effect: the detoxifcation removing the necrotic tissue and promoting granulation, the treatment due to intestine erosion and ulcer has antiulcer, the autoimmunity depression effect.
BINGPENG SAN consists of: Borneolum Syntheticum, Borax (forging), Cinnabaris (cinnabar), Matrii Sulfas Exsiccatus (Natrii Sulfas makes through the air slaking drying, main contains sodium sulfate).
Mannosum Kaki, sweet, cold.Function cures mainly: secretion replenishing and throat moistening, nourishing the lung to arrest cough.Be used for aphtha, throat pain, dry pharynx cough.
Side of the present invention separates:
The holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention adopts many group drug combinations, cooperatively interacts between medicine group and the group, and collaborative the promotion improved whole drug effect.
Fry Herba Xanthii, Flos Magnoliae, the Radix Angelicae Dahuricae, Periostracum Cicadae, Herba Spirodelae, Herba Asari, Herba Ephedrae, Rhizoma Chuanxiong dispelling wind to relieve the exterior syndrome, but the headache of cold-dispelling, wind heat, control under nasal obstruction, watery nasal discharge, the nasal sinusitis tears more than, anosmia; Add Rhizoma Atractylodis, Herba Pogostemonis, Herba Menthae, removing dampness by means of aromatics, dispel turbid sensible; Rhizoma Coptidis, Herba Centellae, Folium Hibisci Mutabilis, Lasiosphaera Seu Calvatia, Flos Lonicerae, Indigo Naturalis (XILEI SAN contains), Fel Sus domestica, liver heat removing function of gallbladder promoting, damp eliminating is induced sweat, the pathogenic fire reducing detumescence, Nidus Vespae, Scolopendra, Dens Elephatis (XILEI SAN contains), Concha (XILEI SAN contains), Venenum Bufonis, Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, the eliminating stagnation blood stasis dispelling is except polyp, the meridian dredging, removing the necrotic tissue and promoting granulation; Bulbus Fritillariae Thunbergii, Flos Caryophylli, Margarita powder reduce phlegm, eliminating stagnation, collateral dredging, blood stasis dispelling, Flos Caryophylli, Margarita powder antiulcer, antiinflammatory antiviral, removing toxic substances and promoting granulation; Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Calyx Seu Fructus Physalis throat, wild Ganoderma, Periostracum Cicadae, Radix Saposhnikoviae, Membrana Follicularis ovi have the effect of antiallergic.Borneolum Syntheticum (BINGPENG SAN contains), Moschus, gleditsia officinalis, Rhizoma Acori Graminei, Borax (BINGPENG SAN contains) causing resuscitation with aromatic drugs, Moschus 12 warps that pass through add Borneolum Syntheticum and also can promote drug absorption, and the Borax detoxifcation is anticorrosion; Moschus, Borneolum Syntheticum can be accelerated drug absorption speed.Oral cavity and nose, pharyngeal communicating, mucosa links to each other.Chinese medicine Moschus, Borneolum Syntheticum, Flos Magnoliae can be fumigated nasal cavity, nasopharynx part and play the awakening consciousness effect when holding in the mouth for dissolving drug.
Moschus, Borneolum Syntheticum fragrance are walked to alter, and having one's ideas straightened out, it is dirty to ward off; The clear away heart-fire detoxifcation; Margarita, tranquillization with heavy prescription.All medicines share, and have to ward off the merit that dirty detoxifcation is had one's ideas straightened out, and Calculus Bovis, Margarita powder, Borneolum Syntheticum, Borax medical instrument have the merit of fragrance, heat radiation, detoxifcation, so can control the pharyngalgia aphtha, wind heat is hidden from view.
Nasopharyngitis is not that simple rhinitis adds pharyngitis, but because cavum nasopharyngeum is subject to the inflammation that the invasion of virus, antibacterial causes afterwards.Herba Dracocephali Integrifolii, bitter in the mouth, warm in nature.Have eliminate the phlegm, cough-relieving, the function of relievining asthma.Folium Ginkgo enters lung meridian, can treat asthma, alleviate irritated, but Mannosum Kaki secretion replenishing and throat moistening, profit cardiopulmonary, Calyx Seu Fructus Physalis Anhydroalkannin, antibiotic, antiviral, adjusting immune system.Herba Dracocephali Integrifolii is main, is aided with Folium Ginkgo, Mannosum Kaki and Calyx Seu Fructus Physalis, can strengthen relieving cough and asthma, antiinflammatory, the antibacterial effect of Herba Dracocephali Integrifolii, for by virus, bacterial nasopharyngitis preferably therapeutic effect being arranged.
Phellinus igniarius (L. ex Fr.) Quel. can stop blooding, invigorate blood circulation, and Membrana Follicularis ovi can be repaired mucosal tissue, is rich in asiaticoside in the Herba Centellae and can promotes wound healing, and the hot cold of Herba Spirodelae is delivered, line water detumescence.Phellinus igniarius (L. ex Fr.) Quel., Membrana Follicularis ovi, Herba Centellae, Herba Spirodelae coupling can accelerate to repair nose and pharyngeal impaired mucosa, removing the necrotic tissue, more wound, granulation promoting in treatment.
Cinnabaris (BINGPENG SAN contains), Bulbus Fritillariae Thunbergii and Venenum Bufonis coupling can reduce Venenum Bufonis toxicity to the stimulation of pharyngeal mucosa, collaborative enhancing is relievingd asthma, the effect of antitussive, antiinflammatory, the analgesia anaesthetic effect of Venenum Bufonis can be alleviated again pharyngalgia, rhinocnesmus, headache that nasopharyngitis is brought, and reduction of patient is uncomfortable.
The ephedrine that contains in the Herba Ephedrae can relax bronchial smooth muscle, vasoconstrictive are alleviated and prevention of asthma, treat simultaneously nasal mucosa effect congested and nasal obstruction fast and lasting.Folium Ginkgo has excellent antiallergic and the effect of relievining asthma.It is congested that Herba Ephedrae, Semen Ginkgo coupling can be alleviated nasal obstruction and nasal mucosa that allergic rhinitis brings, has the effect of Prevention asthma, and mucosa chronic congestion, the dry cough simultaneously also can the relieve chronic nasopharyngitis brought have foreign body sensation, dyspneic symptom bitterly.
The holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention adopts Mel and Cera Flava to do binding agent, and preferably adhesiveness and sustained release rate are arranged.With the erodible framework material (again be called wax lipid skeleton) of natural Cera Flava as oral cavity holding in the mouth for dissolving drug pill.Because the gradually dissolved substance of Cera Flava slowly discharges, and is subjected to the restriction of temperature thereupon, can not cause the such fast softening dissolving of honeyed pill and washed by saliva, swallow.But slow lasting lasting molten release thing has reduced the rinse capability of saliva to medicament.Increase, prolonged the treatment time of medicine.
In the holding in the mouth for dissolving drug process, under the effect along with the temperature in the oral cavity, saliva, Cera Flava, Mel, the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention heats up gradually in taking process, and slowly melts.Because oral cavity and nasal cavity communicate, can be in the holding in the mouth for dissolving drug process along with the thawing slow release of fragrant medicine, to the cavity of nasal cavity have stifling, change the effect of melting.
The preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, in the step 1), Chinese medicine powder is crossed 100 mesh sieves, sifts out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, the absorption of fine powder is better, gives over to subsequent step 2) and step 3) in make super fine; With residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner obtains concentrated solution, purpose is the effective ingredient of medical material of further purifying.
Concentrated solution is as step 2) in water-phase component mix with the fine powder that accounts for Chinese medicine powder gross mass 1/5th.Reason is that concentrated solution Chinese medicine effective ingredient dissolution velocity in water is very fast, adopts concentrated solution to mix the dissolution velocity that can slow down active ingredient with fine powder.The fine powder consumption that accounts for Chinese medicine powder gross mass 1/5th can guarantee the pill volume suitable size holding in the mouth for dissolving drug made, and the pill dissolution velocity is slower simultaneously, and drug effect is better.Fine powder has viscosity as binding agent as filling, Cera Flava as erodible skeleton, the refined honey of pill.
In the step 3) with concentrated traditional Chinese medicine and Moschus, BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixing, reason is Moschus, BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge and can cause harmful effect to drug effect after Asteriscus Pseudosciaenae, Mannosum Kaki temperature surpass 60 ℃, therefore can not be in step 2) in directly mix with concentrated solution.Pulverized 1000 ~ 2000 mesh sieves in the step 3) and obtain super fine, 1000 ~ 2000 order super fines can be so that mucosa delivery absorbs convenience;
In the step 4) refined honey is heated, when reaching 110 ~ 115 ℃, temperature adds Cera Flava, then slowly put into super fine, will add Cera Flava under the higher temperature and can improve the dispersibility of Cera Flava in pill, make the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention have comparatively stably dissolution velocity.
A kind of usage for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention is characterized in that: adopt oral holding in the mouth for dissolving drug, one time 3 ~ 5 gram of being grown up, 4 times on the one; Perhaps, with hot Oleum sesami pill is ground out the furnishing ointment, dip the balm daubing nasal cavity with swab stick; Perhaps, after grinding of pill, with in mass ratio pill: water=1:1 ~ 15 dilutions of boiled water, carry out coloclysis.
Compared with prior art, the beneficial effect that has of holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention and preparation method thereof is:
1, the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is rapid-action and have no side effect.By mucosa delivery, directly act on oral cavity, periodontal, pharynx, throat's mucosa and play local directly targeted therapy effect.Rapid-action, can avoid liver to be subjected to the Degradation of effect and gastrointestinal.Approximately 200CM oral mucosa area has abundant blood vessel to absorb the drug and directly enters blood circulation, and is higher 4 ~ 400 times than skin permeability because mucosa is thinner than skin, easilier penetrated and is absorbed by medicine.Oral mucosa is stronger than nasa tolerance property, not easy damaged.Directly entering body by oral cavity and the direct absorption of hypoglossis mucous membrane circulates safer, effective;
2, the holding in the mouth for dissolving drug slow release traditional Chinese medicine slow-releasing effect for the treatment of nasopharyngitis of the present invention is excellent, adopt Mel and Cera Flava to do binding agent, Cera Flava is again as the erodible framework material of oral cavity holding in the mouth for dissolving drug pill, make the effective ingredient in the pill dissolve gradually, slowly discharge, existing honeyed pill, the softening dissolving of buccal tablets have been solved fast, the problem of easily being washed, swallowing by saliva.The holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time for the treatment of nasopharyngitis of the present invention is long, and the holding in the mouth for dissolving drug slow release Chinese medicine holding in the mouth for dissolving drug time of 3 ~ 5 grams treatment nasopharyngitis of the present invention is 50 ~ 60 minutes, and the holding in the mouth for dissolving drug time is existing honeyed pill, buccal tablets holding in the mouth for dissolving drug time 1 ~ 2 times;
3, the holding in the mouth for dissolving drug slow release Chinese medicine of the treatment nasopharyngitis of the present invention lung qi dispersing that can dispel the wind, clearing away heat and expelling pathogen in the exterior, antiallergic dehumidifying, brain is protected in liver heat removing, has one's ideas straightened out that it is turbid to drive, removing the necrotic tissue and promoting granulation, excellent to treatment acute nasopharyngitis and chronic nasopharyngitis's effect, totall effective rate in clinical treatment 93%, cure rate 87%." method of external treatment is the reason for the treatment of by oral administration of medicines " external treatment can be capable with Nei Zhi And, mends the too late for the treatment of by oral administration of medicines, not only is used for nasopharyngitis, also can treat acute rhinitis, chronic rhinitis, allergic rhinitis, sinusitis, acute, chronic pharyngitis.Both can remove nasal obstruction after patient once adds medicine to, improve ventilation.After the pharyngeal medication for several times, itching throat, dry pharynx alleviate.The convenient for children medication; Medicine is good, amount less, cost is low.Reduced medical expense, improved curative effect, mouthfeel is suitable, should be accepted by the patient;
4, the preparation method of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention can improve the drug effect of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention, the slow-release time of prolong drug;
5, the usage of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is easy to operate, ends treatment and can take out at any time.And have and, when the patient is not easy to the holding in the mouth for dissolving drug administration, can adopt the mode of nasal-cavity administration and coloclysis administration to treat.During nasal-cavity administration, select hot Oleum sesami that pill is ground out the furnishing balm daubing at nasal cavity, Oleum sesami contains abundant vitamin E and linoleic acid, the active ingredient of the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention is dissolved in the Oleum sesami, be easier to by Nasal Mucosa Absorption, Oleum sesami has preferably moisturizing effect simultaneously, can moisten dry nasal cavity.
The specific embodiment
Embodiment 1 ~ 6th, the specific embodiment of holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention and preparation method thereof, and wherein embodiment 3 is preferred forms.
Embodiment 1
Preparation method is as follows:
1) by weight with 31 parts of Herba Dracocephali Integrifolii, 25 parts of Rabdosia rubescens, 21 parts of Phellinus igniarius (L. ex Fr.) Quel., 19 parts of Folium Ginkgos, 11 parts of Herba Centipedae, 9 parts of Folium Hibisci Mutabiliss, 9.5 parts in Herba Spirodelae, fry 9 parts of Herba Xanthiis, 21 parts of Herba Centellaes, 5.5 parts of Herba Asaris, 8 parts in Herba Ephedrae, 8.5 parts of Rhizoma Chuanxiongs, 11 parts of Flos Magnoliaes, 4.5 parts of Scolopendras, 7 parts of Margarita powder, 9 parts of Flos Loniceraes, forge 11 parts of Asteriscus Pseudosciaenaes, 9 parts of Rhizoma Acori Graminei, 9 parts of Nidus Vespaes, 5.5 parts of Flos Caryophyllis, 8 parts of Rhizoma Coptidis, 1.5 parts of Venenum Bufoniss, 9 parts of Radix Sophorae Tonkinensiss, 9 parts of Rhizoma Belamcandae, 15 parts of Calyx Seu Fructus Physaliss, 6 parts of Membrana Follicularis ovis, 9 parts of the Radixs Angelicae Dahuricae, 9 parts of Periostracum Cicadaes, 10 parts of Lasiosphaera Seu Calvatia, 15 parts of wild Ganodermas, Calculus Bovis 1.5, Fel Sus domestica is mixed 8 parts of Herba Pogostemoniss, 10 parts of Bulbus Fritillariae Thunbergii, 9 parts of gleditsia officinalises, 10 parts of XILEI SAN, pulverize the acquisition Chinese medicine powder after 20 parts of mixing of Mannosum Kaki, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, with residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio the 1:5 decocting boil, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 65 ℃ of oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2.2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.Cera Flava is yellow beeswax.
Embodiment 2
Preparation method is as follows:
1) by weight with 29 parts of Herba Dracocephali Integrifolii, 30 parts of Rabdosia rubescens, 20 parts of Phellinus igniarius (L. ex Fr.) Quel., 21 parts of Folium Ginkgos, 10.5 parts of Herba Centipedae, 10 parts of Folium Hibisci Mutabiliss, 9 parts in Herba Spirodelae, fry 9.5 parts of Herba Xanthiis, 20.5 parts of Herba Centellaes, 5 parts of Herba Asaris, 8.5 parts in Herba Ephedrae, 8 parts of Rhizoma Chuanxiongs, 10 parts of Flos Magnoliaes, 5 parts of Scolopendras, 6 parts of Margarita powder, 10 parts of Flos Loniceraes, forge 11 parts of Asteriscus Pseudosciaenaes, 9.5 parts of Rhizoma Acori Graminei, 9.5 parts of Nidus Vespaes, Flos Caryophylli 6, Rhizoma Coptidis 9,1.5 parts of Venenum Bufoniss, 9 parts of Radix Sophorae Tonkinensiss, 9 parts of Rhizoma Belamcandae, 15 parts of Calyx Seu Fructus Physaliss, 6 parts of Membrana Follicularis ovis, 9 parts of the Radixs Angelicae Dahuricae, 9 parts of Periostracum Cicadaes, 10 parts of Lasiosphaera Seu Calvatia, 15 parts of wild Ganodermas, Calculus Bovis 2, Fel Sus domestica is mixed 9 parts of Herba Pogostemoniss, 10 parts of Bulbus Fritillariae Thunbergii, 9 parts of gleditsia officinalises, 10 parts of XILEI SAN, pulverize the acquisition Chinese medicine powder after 20 parts of mixing of Mannosum Kaki, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, with residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.Cera Flava is the refine Cera Flava.
Embodiment 3
Preparation method is as follows:
1) by weight with 30 parts of Herba Dracocephali Integrifolii, 27 parts of Rabdosia rubescens, 20 parts of Phellinus igniarius (L. ex Fr.) Quel., 20 parts of Folium Ginkgos, 10 parts of Herba Centipedae, 10 parts of Folium Hibisci Mutabiliss, 10 parts in Herba Spirodelae, fry 10 parts of Herba Xanthiis, 20 parts of Herba Centellaes, 5 parts of Herba Asaris, 9 parts in Herba Ephedrae, 9 parts of Rhizoma Chuanxiongs, 10 parts of Flos Magnoliaes, 5 parts of Scolopendras, 6 parts of Margarita powder, 10 parts of Flos Loniceraes, forge 10 parts of Asteriscus Pseudosciaenaes, 10 parts of Rhizoma Acori Graminei, 10 parts of Nidus Vespaes, Flos Caryophylli 6, Rhizoma Coptidis 9,1.5 parts of Venenum Bufoniss, 9 parts of Radix Sophorae Tonkinensiss, 9 parts of Rhizoma Belamcandae, 15 parts of Calyx Seu Fructus Physaliss, 6 parts of Membrana Follicularis ovis, 9 parts of the Radixs Angelicae Dahuricae, 9 parts of Periostracum Cicadaes, 10 parts of Lasiosphaera Seu Calvatia, 15 parts of wild Ganodermas, Calculus Bovis 2, Fel Sus domestica is mixed 9 parts of Herba Pogostemoniss, 10 parts of Bulbus Fritillariae Thunbergii, 9 parts of gleditsia officinalises, 10 parts of XILEI SAN, pulverize the acquisition Chinese medicine powder after 20 parts of mixing of Mannosum Kaki, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, with residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is preferably in and dries acquisition winter.Cera Flava is cera alba.
Embodiment 4
Preparation method is as follows:
1) by weight with 33 parts of Herba Dracocephali Integrifolii, 26 parts of Rabdosia rubescens, 22 parts of Phellinus igniarius (L. ex Fr.) Quel., 18 parts of Folium Ginkgos, 9 parts of Herba Centipedae, 9 parts of Folium Hibisci Mutabiliss, 11 parts in Herba Spirodelae, fry 9 parts of Herba Xanthiis, 22 parts of Herba Centellaes, 5.5 parts of Herba Asaris, 10 parts in Herba Ephedrae, 8 parts of Rhizoma Chuanxiongs, 9 parts of Flos Magnoliaes, 5.5 parts of Scolopendras, 7 parts of Margarita powder, 10 parts of Flos Loniceraes, forge 10 parts of Asteriscus Pseudosciaenaes, 10 parts of Rhizoma Acori Graminei, 10 parts of Nidus Vespaes, Flos Caryophylli 6, Rhizoma Coptidis 9,1.5 parts of Venenum Bufoniss, 9 parts of Radix Sophorae Tonkinensiss, 9 parts of Rhizoma Belamcandae, 15 parts of Calyx Seu Fructus Physaliss, 7 parts of Membrana Follicularis ovis, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Periostracum Cicadaes, 11 parts of Lasiosphaera Seu Calvatia, 15 parts of wild Ganodermas, Calculus Bovis 2, Fel Sus domestica is mixed 9 parts of Herba Pogostemoniss, 10 parts of Bulbus Fritillariae Thunbergii, 9 parts of gleditsia officinalises, 10 parts of XILEI SAN, after mixing, Mannosum Kaki 20 pulverizes the acquisition Chinese medicine powder, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, with residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.Cera Flava is cera alba.
Embodiment 5
Preparation method is as follows:
1) by weight with 27 parts of Herba Dracocephali Integrifolii; 28 parts of Rabdosia rubescens; 22 parts of Phellinus igniarius (L. ex Fr.) Quel.; 18 ~ 22 parts of Folium Ginkgos; 9 ~ 11 parts of Herba Centipedae; 11 parts of Folium Hibisci Mutabiliss; 9 parts in Herba Spirodelae; fry 9 parts of Herba Xanthiis, 22 parts of Herba Centellaes; 5.5 parts of Herba Asaris; 10 parts in Herba Ephedrae; 8 parts of Rhizoma Chuanxiongs; 9 parts of Flos Magnoliaes; 4.5 parts of Scolopendras; 7 parts of Margarita powder; 11 parts of Flos Loniceraes; forge 9 parts of Asteriscus Pseudosciaenaes; 11 parts of Rhizoma Acori Graminei; 9 parts of Nidus Vespaes; 5.5 parts of Flos Caryophyllis; 8 parts of Rhizoma Coptidis; 1.8 parts of Venenum Bufoniss; 8 parts of Radix Sophorae Tonkinensiss; 10 parts of Rhizoma Belamcandae; 13.5 parts of Calyx Seu Fructus Physaliss; 7 parts of Membrana Follicularis ovis; 8 parts of the Radixs Angelicae Dahuricae; 8 parts of Periostracum Cicadaes; 9 parts of Lasiosphaera Seu Calvatia; 13.5 parts of wild Ganodermas; 1.5 parts in Moschus; 2.4 parts of Calculus Boviss; Fel Sus domestica is mixed 8 parts of Herba Pogostemoniss; 9 parts of Bulbus Fritillariae Thunbergii; 10 parts of gleditsia officinalises; 11 parts of XILEI SAN; 9 parts of BINGPENG SAN; 18 parts of Mannosum Kakis
Pulverize the acquisition Chinese medicine powder after the mixing, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, the coarse powder that residue is accounted for Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water filter cleaner, acquisition concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.Cera Flava is cera alba.
Embodiment 6
Preparation method is as follows:
1) by weight with 33 parts of Herba Dracocephali Integrifolii, 29 parts of Rabdosia rubescens, 18 parts of Phellinus igniarius (L. ex Fr.) Quel., 22 parts of Folium Ginkgos, 9 parts of Herba Centipedae, 9 parts of Folium Hibisci Mutabiliss, 11 parts in Herba Spirodelae, fry 11 parts of Herba Xanthiis, 18 parts of Herba Centellaes, 4.5 parts of Herba Asaris, 8 parts in Herba Ephedrae, 10 parts of Rhizoma Chuanxiongs, 11 parts of Flos Magnoliaes, 5.5 parts of Scolopendras, 5.5 parts of Margarita powder, 9 parts of Flos Loniceraes, forge 11 parts of Asteriscus Pseudosciaenaes, 9 parts of Rhizoma Acori Graminei, 11 parts of Nidus Vespaes, 7 parts of Flos Caryophyllis, 10 parts of Rhizoma Coptidis, 1.2 parts of Venenum Bufoniss, 8 parts of Radix Sophorae Tonkinensiss, 10 parts of Rhizoma Belamcandae, 18 parts of Calyx Seu Fructus Physaliss, 5.5 parts of Membrana Follicularis ovis, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Periostracum Cicadaes, 11 parts of Lasiosphaera Seu Calvatia, 18 parts of wild Ganodermas, 1.5 parts in Moschus, 2.4 parts of Calculus Boviss, Fel Sus domestica is mixed 8 parts of Herba Pogostemoniss, 11 parts of Bulbus Fritillariae Thunbergii, 10 parts of gleditsia officinalises, 9 parts of XILEI SAN, 11 parts of BINGPENG SAN, pulverize the acquisition Chinese medicine powder after 22 parts of mixing of Mannosum Kaki, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, with residue account for the coarse powder of Chinese medicine powder gross mass 4/5ths and water in mass ratio 1:6 decoct with water, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and 2 parts in Moschus, 10 parts of BINGPENG SAN, Borneolum Syntheticum, Margarita powder, forge Asteriscus Pseudosciaenae, Mannosum Kaki mixes, pulverize 1000 ~ 2000 mesh sieves and obtained super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds the Cera Flava that accounts for refined honey quality 5 ~ 8%, and be the addition of 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
The preferred Xinjiang of Herba Dracocephali Integrifolii Herba Dracocephali Integrifolii.Fel Sus domestica is mixed Fel Sus domestica and in mass ratio 1:1 mixing immersion of Herba Pogostemonis in the Herba Pogostemonis, is dried acquisition.Cera Flava is cera alba.
Clinical practice of the present invention is summarized as follows:
The chronic nasopharyngitis.
Nasopharynx part is dry congested or red and swollen, secretions is arranged, examination of nasopharynx is seen the mucosa chronic congestion, hypertrophy is plump, coated with secretions or dry crusts, hoarseness, pharyngalgia, headache, dizziness, weak, clear (pus) nasal mucus of nasal obstruction, sneeze, stream, nasopharynx part are itched, dry cough has foreign body sensation bitterly, dyspnea, dizzy headache, weak, hyposmia, hypomnesis.Leukocyte count is normal or on the low side during viral infection, and percentage of lymphocyte raises.During bacterial infection, leukocyte count increasing proportion and shift to left phenomenon, neutrophilic granulocyte increasing proportion and shift to left phenomenon.Nasopharynx is dry uncomfortable, has thickness sample secretions to be difficult for expectoration, therefore patient coughs frequently often with feeling sick.Severe patient has whole body or the local symptoms such as hoarseness, pharyngalgia, headache, dizziness, weak, dyspepsia, low grade fever.
Acute nasopharyngitis.
Be under full nasopharynx part mucosa, the mucosa and adenoid acute inflammation, mainly betide pharyngeal tonsil.Nasal obstruction, watery nasal discharge, headache and nasopharynx part are done pain, burning sensation, foreign body sensation.Examination of nasopharynx is seen mucosa acute congestion edema, and has volume mucopurulent secretion thing to adhere to, and secretions can be dirty along the pharynx rear wall.
Allergic rhinitis.
Cause (such as demodicid mite, pollen, animal scurf, fungus) by particular allergen.Every day is paroxysmal sneeze for several times, how to show effect at once after contact allergy is former; Thin nasal discharge, nasal obstruction, intranasal is itched, pale, the two Carapax et Plastrum Testudinis edema of sharp nasal mucosa, visible thin nasal discharge or glutinous tears at the bottom of meatus nasi communis and the nose.
Sinusitis.
Nasal obstruction, the pus tears, Head And Face distension and constriction, olfactory sensation changes.Nasal cavity checks: the congested swelling of nasal membrane, especially locate as obviously with middle nasal concha, middle nasal meatus and olfactory cleft etc.The front group of visible middle nasal meatus's empyema of sinusitis, the scorching visible olfactory cleft empyema of posterior nasal sinuses, or pus flow to choana from the top.
Chronic rhinitis.
Do during nasal obstruction, nasal mucus pus is thick to be increased, dizzy headache, olfactory disorder.The concha nasalis enlargement, in, the concha nasalis inferior enlargement is common, the middle nasal concha enlargement then is the vital sign of primary disease, the congested swelling of mucosa or mucosa flushing, mucosa is light red, locates as seen to have stickiness or glutinous purulent secretion at the bottom of middle nasal meatus, olfactory sulcus, the nose etc.
Chronic pharyngitis
Pharyngeal discomfort is done, is itched, swollen, and secretions is many and causalgia is gradually arranged, and easily feels sick, and foreign body sensation is arranged, and that coughs does not go out, and what gulp down is lower, and lateral pharyngeal band is got involved then obvious otalgia.
Acute pharyngitis
Pharyngeal drying, scorching hot, swallow pain.Section's mucous hyperemia swelling is peony, the secretions showed increased.Take the oropharynx lateral wall as outstanding, the swelling of pharyngopalatine arch mucosa.The enlargement of pharynx rear wall lymph follicle, hyperemia.Soft palate and tonsil are also congested.
A kind of usage for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis of the present invention is characterized in that: adopt oral holding in the mouth for dissolving drug, one time 3 ~ 5 gram of being grown up, 4 times on the one; Using 7 days continuously is 1 course for the treatment of.Or when nasal obstruction is serious, with hot Oleum sesami pill is ground out the furnishing ointment, dip the balm daubing nasal cavity with swab stick.
Curative effect judging standard: the improvement situation according to above-mentioned symptom is divided into curative effect healing, takes a turn for the better and does not heal, and uses effective effect in the described course for the treatment of according to aforementioned disease classification, and total effective rate is cure rate and improvement rate sum.Use continuously the holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis of the present invention to add up after 2 ~ 3 courses for the treatment of, statistical result is as shown in table 1:
Table 1 is the case statistics for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis with the present invention
Total effective 3390 examples, 3185 examples of fully recovering are taken in 2～3 courses for the treatment of total effective rate 93%, cure rate 87%.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (5)
1. holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis; it is characterized in that; raw material by following weight portion is made: 27 ~ 33 parts of Herba Dracocephali Integrifoliis; 25 ~ 30 parts of Rabdosia rubescens; 18 ~ 22 parts of Phellinus igniarius (L. ex Fr.) Quel.; 18 ~ 22 parts of Folium Ginkgos; 9 ~ 11 parts of Herba Centipedae; 9 ~ 11 parts of Folium Hibisci Mutabiliss; 9 ~ 11 parts in Herba Spirodelae; fry 9 ~ 11 parts of Herba Xanthiis, 18 ~ 22 parts of Herba Centellaes; 4.5 ~ 5.5 parts of Herba Asaris; 8 ~ 10 parts in Herba Ephedrae; 8 ~ 10 parts of Rhizoma Chuanxiongs; 9 ~ 11 parts of Flos Magnoliaes; 4.5 ~ 5.5 parts of Scolopendras; 5.5 ~ 7 parts of Margarita powder; 9 ~ 11 parts of Flos Loniceraes; forge 9 ~ 11 parts of Asteriscus Pseudosciaenaes; 9 ~ 11 parts of Rhizoma Acori Graminei; 9 ~ 11 parts of Nidus Vespaes; 5.5 ~ 7 parts of Flos Caryophyllis; 8 ~ 10 parts of Rhizoma Coptidis; 1.2 ~ 1.8 parts of Venenum Bufoniss; 8 ~ 10 parts of Radix Sophorae Tonkinensiss; 8 ~ 10 parts of Rhizoma Belamcandae; 13.5 ~ 18 parts of Calyx Seu Fructus Physaliss; 5.5 ~ 7 parts of Membrana Follicularis ovis; 8 ~ 10 parts of the Radixs Angelicae Dahuricae; 8 ~ 10 parts of Periostracum Cicadaes; 9 ~ 11 parts of Lasiosphaera Seu Calvatia; 13.5 ~ 18 parts of wild Ganodermas; 1.5 ~ 2.4 parts in Moschus; 1.5 ~ 2.4 parts of Calculus Boviss; Fel Sus domestica is mixed 8 ~ 10 parts of Herba Pogostemoniss; 9 ~ 11 parts of Bulbus Fritillariae Thunbergii; 8 ~ 10 parts of gleditsia officinalises; 9 ~ 11 parts of XILEI SAN; 9 ~ 11 parts of BINGPENG SAN; 18 ~ 22 parts of Mannosum Kakis.
2. a kind of holding in the mouth for dissolving drug slow release Chinese medicine for the treatment of nasopharyngitis according to claim 1; it is characterized in that; raw material by following weight portion is made: 29 ~ 31 parts of Herba Dracocephali Integrifoliis; 26 ~ 29 parts of Rabdosia rubescens; 19 ~ 21 parts of Phellinus igniarius (L. ex Fr.) Quel.; 19 ~ 21 parts of Folium Ginkgos; 10 ~ 11 parts of Herba Centipedae; 9 ~ 10 parts of Folium Hibisci Mutabiliss; 9 ~ 10 parts in Herba Spirodelae; fry 9 ~ 10 parts of Herba Xanthiis, 20 ~ 21 parts of Herba Centellaes; 5 ~ 5.5 parts of Herba Asaris; 8 ~ 9 parts in Herba Ephedrae; 8 ~ 9 parts of Rhizoma Chuanxiongs; 10 ~ 11 parts of Flos Magnoliaes; 4.5 ~ 5 parts of Scolopendras; 6 ~ 7 parts of Margarita powder; 9 ~ 10 parts of Flos Loniceraes; forge 10 ~ 11 parts of Asteriscus Pseudosciaenaes; 9 ~ 10 parts of Rhizoma Acori Graminei; 9 ~ 10 parts of Nidus Vespaes; 5.5 ~ 6 parts of Flos Caryophyllis; 8 ~ 9 parts of Rhizoma Coptidis; 1.4 ~ 1.6 parts of Venenum Bufoniss; 8.5 ~ 9.5 parts of Radix Sophorae Tonkinensiss; 8.5 ~ 9.5 parts of Rhizoma Belamcandae; 14 ~ 16 parts of Calyx Seu Fructus Physaliss; 5.5 ~ 6.5 parts of Membrana Follicularis ovis; 9 ~ 10 parts of the Radixs Angelicae Dahuricae; 9 ~ 10 parts of Periostracum Cicadaes; 9 ~ 11 parts of Lasiosphaera Seu Calvatia; 13.5 ~ 18 parts of wild Ganodermas; 1.9 ~ 2.2 parts in Moschus; 1.9 ~ 2.2 parts of Calculus Boviss; Fel Sus domestica is mixed 9 ~ 10 parts of Herba Pogostemoniss; 9 ~ 10 parts of Bulbus Fritillariae Thunbergii; 8.5 ~ 9.5 parts of gleditsia officinalises; 9 ~ 10 parts of XILEI SAN; 10 ~ 11 parts of BINGPENG SAN; 19 ~ 21 parts of Mannosum Kakis.
3. the holding in the mouth for dissolving drug slow release Chinese medicine of described a kind for the treatment of nasopharyngitis according to claim 1; it is characterized in that; raw material by following weight portion is made: 30 parts of Herba Dracocephali Integrifoliis; 27 parts of Rabdosia rubescens; 20 parts of Phellinus igniarius (L. ex Fr.) Quel.; 20 parts of Folium Ginkgos; 10 parts of Herba Centipedae; 10 parts of Folium Hibisci Mutabiliss; 10 parts in Herba Spirodelae; fry 10 parts of Herba Xanthiis; 20 parts of Herba Centellaes; 5 parts of Herba Asaris; 9 parts in Herba Ephedrae; 9 parts of Rhizoma Chuanxiongs; 10 parts of Flos Magnoliaes; 5 parts of Scolopendras; 6 parts of Margarita powder; 10 parts of Flos Loniceraes; forge 10 parts of Asteriscus Pseudosciaenaes; 10 parts of Rhizoma Acori Graminei; 10 parts of Nidus Vespaes; Flos Caryophylli 6; Rhizoma Coptidis 9; 1.5 parts of Venenum Bufoniss; 9 parts of Radix Sophorae Tonkinensiss; 9 parts of Rhizoma Belamcandae; 15 parts of Calyx Seu Fructus Physaliss; 6 parts of Membrana Follicularis ovis; 9 parts of the Radixs Angelicae Dahuricae; 9 parts of Periostracum Cicadaes; 10 parts of Lasiosphaera Seu Calvatia; 15 parts of wild Ganodermas; 2 parts in Moschus; Calculus Bovis 2; Fel Sus domestica is mixed 9 parts of Herba Pogostemoniss, 10 parts of Bulbus Fritillariae Thunbergii; 9 parts of gleditsia officinalises; 10 parts of XILEI SAN; 10 parts of BINGPENG SAN; 20 parts of Mannosum Kakis.
4. a preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis is characterized in that, adopts following steps:
1) by weight with Herba Dracocephali Integrifolii, Rabdosia rubescens, Phellinus igniarius (L. ex Fr.) Quel., Folium Ginkgo, Herba Centipedae, Folium Hibisci Mutabilis, Herba Spirodelae, fry Herba Xanthii, Herba Centellae, Herba Asari, Herba Ephedrae, Rhizoma Chuanxiong, Flos Magnoliae, Scolopendra, Flos Lonicerae, Rhizoma Acori Graminei, Nidus Vespae, Flos Caryophylli, Rhizoma Coptidis, Venenum Bufonis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Calyx Seu Fructus Physalis, Membrana Follicularis ovi, the Radix Angelicae Dahuricae, Periostracum Cicadae, Lasiosphaera Seu Calvatia, wild Ganoderma, Calculus Bovis, Fel Sus domestica is mixed Herba Pogostemonis, Bulbus Fritillariae Thunbergii, gleditsia officinalis, XILEI SAN is pulverized the acquisition Chinese medicine powder after mixing, cross 100 mesh sieves, sift out the fine powder that accounts for Chinese medicine powder gross mass 1/5th, the coarse powder and the water that residue are accounted for Chinese medicine powder gross mass 4/5ths boil 1:5 ~ 7 in mass ratio, filter cleaner obtains concentrated solution;
2) fine powder that accounts for Chinese medicine powder gross mass 1/5th in concentrated solution and the step 1) is mixed mix thoroughly, 60 ~ 70 ℃ of lower oven dry, obtain concentrated traditional Chinese medicine;
3) with concentrated traditional Chinese medicine and Moschus, BINGPENG SAN, Margarita powder are forged Asteriscus Pseudosciaenae, Mannosum Kaki mixing, pulverize 1000 ~ 2000 mesh sieves and obtain super fine;
4) with refined honey heating, when reaching 110 ~ 115 ℃, temperature adds Cera Flava, and be 1:1 ~ 1.5 according to super fine with the refined honey mass ratio that contains 5 ~ 8% Cera Flavas then, slowly put into super fine, stir and be 3 ~ 5 gram pills.
5. preparation method for the treatment of the holding in the mouth for dissolving drug slow release Chinese medicine of nasopharyngitis, it is characterized in that: the Cera Flava consumption accounts for 5 ~ 8% of refined honey quality in the step 4).
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| CN103920049A (en) * | 2014-04-28 | 2014-07-16 | 朱新华 | Preparation for quickly treating sinusitis |
| CN105535107A (en) * | 2016-01-25 | 2016-05-04 | 史沛现 | Medicine composition for treating nasopharyngitis and preparing method of medicine composition |
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| CN103920049A (en) * | 2014-04-28 | 2014-07-16 | 朱新华 | Preparation for quickly treating sinusitis |
| CN105535107A (en) * | 2016-01-25 | 2016-05-04 | 史沛现 | Medicine composition for treating nasopharyngitis and preparing method of medicine composition |
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