CN103301038A - Tea tree oil nanoemulsion and preparation method thereof - Google Patents
Tea tree oil nanoemulsion and preparation method thereof Download PDFInfo
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- CN103301038A CN103301038A CN2013102354449A CN201310235444A CN103301038A CN 103301038 A CN103301038 A CN 103301038A CN 2013102354449 A CN2013102354449 A CN 2013102354449A CN 201310235444 A CN201310235444 A CN 201310235444A CN 103301038 A CN103301038 A CN 103301038A
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Abstract
The invention discloses a tea tree oil nanoemulsion. The liquid drop particle size of the nanoemulsion is 10nm-100nm. The nanoemulsion is prepared from the following raw materials in percentage by weight: 9.00%-30.00% of a surfactant, 15.00%-30.00% of a cosurfactant, 3.00%-8.00% of oil, 0.10%-6.00% of tea tree oil and 31.90%-67.00% of distilled water, wherein the total weight percentage of the raw materials is 100%. The tea tree oil nanoemulsion can be used for improving the stability of the tea tree oil in a processing process, improving the solubility of an insoluble substance, enhancing the bioavailability, reducing equipment input and lowering the production cost, and has wide market prospect in the field of cosmetics.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of tea tree oil nano-emulsion preparation, particularly a kind of tea tree oil nano-emulsion of transparent and stable.
Background technology
Tea tree oil canThe wide spectrum antimicrobial is the pure natural plant quintessence oil that the mode of distilling is extracted from the wood Myrtaceae Folium Melaleucae Leucadendrae of port.Colourless to weak yellow liquid, have effects such as characteristic perfume and antibacterial, antiinflammatory, anthelmintic, can crease-resistant, anti-acne, still, it is water insoluble, volatile, poor stability, bioavailability is low, thereby has influenced its effect.
Summary of the invention
At above-mentioned problems of the prior art and defective, the object of the present invention is to provide a kind of content evenly accurately, steady quality, bioavailability height, and prepare easy tea tree oil nano-emulsion.
The technical scheme that realizes the foregoing invention purpose is the tea tree oil nano-emulsion, comprises that mass percent is:
Surfactant 9.00 ﹪～30.00 ﹪, cosurfactant 15.00 ﹪～30.00 ﹪, oily 3.00 ﹪～8.00 ﹪, tea tree oil 0.10 ﹪～6.00 ﹪ and distilled water 31.90 ﹪～67.00 ﹪ form, and total component is 100 ﹪.
Tea tree oil oil nanometer emulsion of the present invention, its optimization formula comprise that mass percent is:
Surfactant 15.00 ﹪～30.00 ﹪, cosurfactant 17.00 ﹪～30.00 ﹪, oily 4.00 ﹪～8.00 ﹪, tea tree oil 0.10 ﹪～6.00 ﹪ and distilled water 31.90 ﹪～60.00 ﹪ form, and total component is 100 ﹪
Tea tree oil nano-emulsion of the present invention, its optimum formula comprise that mass percent is:
A kind of tea tree oil nano-emulsion is characterized in that, is made by following weight percentages: surfactant 24.00 ﹪, cosurfactant 25.00 ﹪, oily 7.11 ﹪, tea tree oil 5.00 ﹪ and distilled water 38.89 ﹪ form, and total component is 100 ﹪.
Described surfactant tween 80;
Described cosurfactant is ethanol or 1,2-propylene glycol;
Described oil is ethyl acetate.
The present invention selects the nonionic surfactant of avirulence and good biocompatibility for use in the selection of surfactant.Nonionic surfactant is more stable in solution, is not subject to the influence of strong electrolyte, inorganic salts, also is not subject to the influence of soda acid, and good with the compatibility of other surfactants, and haemolysis is less.In theory, the preparation of O/W type nanometer emulsion needs the HLB value of surfactant between 8～18, consider preparation technology's simplicity, be the stability of the easy formation of nano-emulsion and the nano-emulsion for preparing, the present invention selects the liquid nonionic surfactant of HLB between 10～15 for use.Surfactant is tween 80.
Hydrophilic and oleophilic value (HLB) for the adjustment form surface-active agent, can further reduce interfacial tension, increase flexibility and the rigidity of film, be inserted in the interfacial film, promote the formation of the film that radius of curvature is very little, enlarge nano-emulsion and form the zone that the present invention selects bland cosurfactant, mainly contain ethanol or 1,2-propylene glycol.
The present invention is according to when the HLB of the required surfactant of emulsifying oil phase is close with surfactant, the principle that formed emulsion is stable, and the oils and fats of selecting for use is ethyl acetate.Be in a liquid state under this oily room temperature.
The preparation method of tea tree oil nanometer emulsion oral liquid of the present invention comprises that specifically step is as follows:
(1) preparation of surfactant phase takes by weighing surfactant by formula proportion, and helps surface activity composite in proportion, calculates the HLB value of this system, stirs.The HLB value of common emulsifying agent can be found in some chemical industry handbooks, as " the chemical products handbook of chemical industry publishing house.Because hydrophile-lipophile balance (HLB) value of surfactant has additive properties, the available quality averaging method is obtained the HLB value of surfactant.For example, after two kinds of surfactant A, B mixed, the hydrophile-lipophile balance HLBAB value of its mixed surfactant was
HLBAB＝（WAHLBA＋WBHLBB）/（WA＋WB）
WA in the formula, WB---the quality of blend surfactants A, B;
HLBA, the HLB value of HLBB---surfactant A, B.
(2) preparation of oil phase is selected oil according to the HLB value of surfactant phase, transfers its ratio, makes the required HLB value of its emulsifying close with the HLB of surfactant phase.
(3) rule in 9:1～1:9 changes surfactant mutually and the ratio of oil phase, to the Fructus Forsythiae oil that wherein adds formula proportion, stirring makes it whole dissolvings, fully stir at 20 ℃～25 ℃ slow adding distil waters, until form clear, viscosity is little and have mobile flaxen nanometer emulsion.
Outward appearance of the present invention is light yellow transparent liquid, has good stability: when ageing stability referred to that this nano-emulsion is preserved under room temperature nature change condition, outward appearance prolonged and the degree that changes in time.This nano-emulsion is transparent lastingly, does not find muddy or precipitation, illustrates that then ageing stability is good.This is an important indicator estimating nano-emulsion.The tea tree oil nano-emulsion is placed test tube, and sealing under the rotating speed of 12000r/min centrifugal 10 minutes, does not have layering, still clear.
That the present invention has is crease-resistant, whiten, the effect of speckle dispelling (such as macula lutea, freckle, senile plaque), the scar of dispelling, anti-acne, and effect is very remarkable.
Tea tree oil nano-emulsion of the present invention compared with prior art, has the following advantages:
1) thermodynamic stability height.Operation is fairly simple during preparation, not phase-splitting, do not precipitate, and bin stability improves;
2) light transmission is good, and any inhomogeneities or sedimentary existence easily are found, and sensible quality improves;
3) have good solubilization, can effectively improve the dissolubility of indissoluble thing;
5) can improve the dissolubility of tea tree oil, improve the bioavailability of tea tree oil, use the back effect to significantly improve;
6) method technology is simple, is fit to large-scale production.
The specific embodiment
Below the embodiment that provides by the inventor further set forth the preparation method of tea tree oil nano-emulsion of the present invention.
Embodiment 1
Accurately take by weighing tween 80 30.0g, ethanol 30.0g, ethyl acetate 8.0g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 0.1g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 2
Accurately take by weighing tween 80 15.0g, ethanol 15.0g, ethyl acetate 2.0g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 1.0g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 3
Accurately take by weighing tween 80 24.0g, ethanol 24.0g, ethyl acetate 6.0g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 0.5g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 4
Accurately take by weighing tween 80 9.0g, ethanol 30.0g, ethyl acetate 3.0g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 2.0g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 5
Accurately take by weighing tween 80 17.0g, ethanol 17.0g, ethyl acetate 4.0g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 3.1g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 6
Accurately take by weighing tween 80 21.0g, ethanol 26.0g, ethyl acetate 6.15g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 4.0g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 7
Accurately take by weighing tween 80 24.0g, ethanol 25.0g, ethyl acetate 7.11g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 5.0g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 8
Accurately take by weighing tween 80 24.65g, ethanol 25.0g, ethyl acetate 7.19g, put into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 0.6g tea tree oil is directly added, stir fully, to wherein slowly adding distilled water, manually stir on adding distil water limit, limit then, and the system viscosity is less during beginning, increase along with the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, when system unexpected when thinning, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Embodiment 9
Accurately take by weighing tween 80 18.0g, 1,2-propylene glycol 26.0g, ethyl acetate 3.0g puts into beaker, under 20 ℃ of room temperature conditions, manually stir its abundant mix homogeneously, the 0.1g tea tree oil is directly added, stir fully, then to wherein slowly adding distilled water, manually stir on adding distil water limit, limit, the system viscosity is less during beginning, and along with the increase of the distillation water yield, it is sticky that system can become, continue to drip and constantly stir, unexpected when thinning when system, what produced this moment namely is stable faint yellow transparent tea tree oil nano-emulsion, claims that its gross weight is 100.0g.
Safety and result of use
Below the embodiment that provides by the inventor further set forth safety and the effect of tea tree oil nano-emulsion of the present invention.
Example 1
Experimenter 30 years old, the woman, skin is black dull.Use the tea tree oil nano-emulsion after 12 hours, skin obviously brightens blast.The shallow-layer cicatrix disappears, such as since repeatedly intravenous injection cause the many places shallow-layer cicatrix on the back of the hand all to disappear, pore attenuates, the skin cunning that tenderizes.Skin is non-stimulated, does not have any untoward reaction, and sense is clearly thoroughly arranged.
Example 2
Experimenter 58 years old, the woman, skin is white partially.Use the tea tree oil nano-emulsion after 12 hours, reparations of all fading of the senile plaque on the back of the hand, the most of disappearances of 30 many places speckles, the very dark several places of spot colors also obviously shoal.The skin cunning that tenderizes that attenuates, non-stimulated, do not have any untoward reaction, and sense is clearly thoroughly arranged.
Claims (3)
1. tea tree oil nano-emulsion, it is characterized in that, made by following weight percentages: surfactant 9.00 ﹪～30.00 ﹪, cosurfactant 15.00 ﹪～30.00 ﹪, oily 3.00 ﹪～8.00 ﹪, tea tree oil 0.10 ﹪～6.00 ﹪ and distilled water 31.90 ﹪～67.00 ﹪ form, and total component is 100 ﹪; Described surfactant tween 80; Described cosurfactant is ethanol or 1,2-propylene glycol; Described oil is ethyl acetate.
2. tea tree oil nano-emulsion according to claim 1, it is characterized in that, made by following weight percentages: surfactant 15.00 ﹪～30.00 ﹪, cosurfactant 17.00 ﹪～30.00 ﹪, oily 4.00 ﹪～8.00 ﹪, tea tree oil 0.10 ﹪～6.00 ﹪ and distilled water 31.90 ﹪～60.00 ﹪ form, and total component is 100 ﹪.
3. a tea tree oil nano-emulsion is characterized in that, is made by following weight percentages: surfactant 24.00 ﹪, cosurfactant 25.00 ﹪, oily 7.11 ﹪, tea tree oil 5.00 ﹪ and distilled water 38.89 ﹪ form.
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Cited By (6)
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| WO2015172607A1 (en) * | 2014-05-11 | 2015-11-19 | 张晓燕 | Yunnan baiyao nanoemulsion and preparation method |
| CN107496604A (en) * | 2017-09-28 | 2017-12-22 | 贵州航生态农牧科技开发有限公司 | A kind of camellia oil nanometer emulsion oral liquid and preparation method thereof |
| CN110200833A (en) * | 2019-06-03 | 2019-09-06 | 五邑大学 | A kind of phloretin nano-emulsion preparation and its preparation method and application |
| CN110898008A (en) * | 2019-12-11 | 2020-03-24 | 扬州大学 | Nano-antibacterial emulsion containing tea tree essential oil and preparation method thereof |
| CN113633614A (en) * | 2021-09-08 | 2021-11-12 | 中国人民解放军陆军军医大学 | Efficient antibacterial natural tea tree essential oil nanoemulsion preparation for treating intractable dental ulcer and preparation method and application thereof |
| CN114601797A (en) * | 2022-03-23 | 2022-06-10 | 扬州大学 | Tea tree oil nano-emulsion for resisting staphylococcus aureus and preparation method and application thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015172607A1 (en) * | 2014-05-11 | 2015-11-19 | 张晓燕 | Yunnan baiyao nanoemulsion and preparation method |
| EA032980B1 (en) * | 2014-05-11 | 2019-08-30 | Сяоянь Чжан | Yunnan baiyao nanoemulsion and preparation method thereof |
| CN107496604A (en) * | 2017-09-28 | 2017-12-22 | 贵州航生态农牧科技开发有限公司 | A kind of camellia oil nanometer emulsion oral liquid and preparation method thereof |
| CN110200833A (en) * | 2019-06-03 | 2019-09-06 | 五邑大学 | A kind of phloretin nano-emulsion preparation and its preparation method and application |
| CN110898008A (en) * | 2019-12-11 | 2020-03-24 | 扬州大学 | Nano-antibacterial emulsion containing tea tree essential oil and preparation method thereof |
| CN113633614A (en) * | 2021-09-08 | 2021-11-12 | 中国人民解放军陆军军医大学 | Efficient antibacterial natural tea tree essential oil nanoemulsion preparation for treating intractable dental ulcer and preparation method and application thereof |
| CN113633614B (en) * | 2021-09-08 | 2023-04-07 | 中国人民解放军陆军军医大学 | Efficient antibacterial natural tea tree essential oil nanoemulsion preparation for treating intractable dental ulcer and preparation method and application thereof |
| CN114601797A (en) * | 2022-03-23 | 2022-06-10 | 扬州大学 | Tea tree oil nano-emulsion for resisting staphylococcus aureus and preparation method and application thereof |
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Application publication date: 20130918 |