CN103295658A - Hot cell - Google Patents
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- CN103295658A CN103295658A CN2013100580356A CN201310058035A CN103295658A CN 103295658 A CN103295658 A CN 103295658A CN 2013100580356 A CN2013100580356 A CN 2013100580356A CN 201310058035 A CN201310058035 A CN 201310058035A CN 103295658 A CN103295658 A CN 103295658A
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- hot cell
- plemum
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Abstract
The invention provides a hot cell capable of lifting cleanliness in a synthesis chamber. The hot cell is configured to comprise a negative pressure chamber (22) capable of keeping pressure in the chamber to be second pressure lower than atmospheric pressure and a positive pressure chamber namely the synthesis chamber (21) capable of keeping the pressure in the chamber to be higher than the pressure of the negative pressure chamber (22). Radioactive substances are prevented from flowing out from the negative pressure chamber (22) to outside of the hot cell (10). Abnormal substances such as dust are prevented from invading from the negative pressure chamber (22) to the positive pressure chamber (21).
Description
Technical field
The present invention relates to a kind of hot cell.
Background technology
The known hot cell (radioactive ray shielded box) that has the radioactive ray shielding wall by shielding radioactive ray transmission to constitute.The device that radiomaterial is labeled as the keeping radiomaterials such as synthesizer of other materials is contained in indoor in the hot cell and uses (for example referring to Patent Document 1).In addition, like this, can indoor hold synthesizer and can suppress radioactive ray also be called synthetic chamber to the chamber of outside transmission.Be provided with the cleaning unit for the air that promotes to synthetic indoor supplying clean degree in the hot cell.Cleaning unit possesses the HEPA filtrator of removing airborne dust (foreign matter) and to the fan of synthetic indoor importing air.The air that cleanliness promote by cleaning unit removal foreign matter is directed in synthetic indoor.On the other hand, the synthetic indoor negative pressure that is retained as is leaked in order not make synthetic indoor air in the hot cell to the outside.
Patent documentation 1: TOHKEMY 2006-343289 communique
In recent years, require further to promote the synthetic indoor cleanliness in hot cell.In above-mentioned hot cell in the past, because therefore the synthetic indoor negative pressure that remains exists air outside not by cleaning unit and to the misgivings of synthesizing indoor intrusion.
Summary of the invention
The object of the present invention is to provide a kind of hot cell that can realize promoting synthetic indoor cleanliness.
The invention provides a kind of hot cell with the radioactive ray shielding wall that suppresses the radioactive ray transmission, this hot cell comprises: the hot cell main body, and it is the case that is formed by the radioactive ray shielding wall; Plemum is formed in this hot cell main body, inside can be remained the 1st air pressure, and accommodate the radiopharmaceutical agent disposal plant; And negative pressure chamber, be formed in the main body of hot cell, inside can be remained the 2nd air pressure low and that force down than atmosphere than the 1st air pressure.
This hot cell owing to constitute possesses the negative pressure chamber that indoor pressure can be remained the 2nd pressure that forces down than atmosphere and can be with the indoor plemum that remains the pressure higher than negative pressure chamber, therefore can prevent that radiomaterial from flowing out from negative pressure chamber's thermotropism outdoor, and prevent that foreign matter (dust, dust etc.) from invading to plemum from negative pressure chamber.Therefore, can provide a kind of realizes suppressing foreign matter and invades in the plemum and promote cleanliness and can prevent the hot cell that radiomaterial flows out.
Preferred negative pressure chamber is disposed between the peristome and plemum of hot cell main body.According to this structure, can dispose negative pressure chamber in the peristome side of hot cell main body, and the plemum of portion's (rear side) configuration within it.Owing to be to possess than plemum more by the structure of the negative pressure chamber of peristome side, can prevent that therefore radiomaterial from flowing out from negative pressure chamber's thermotropism outdoor, and prevent that foreign matter (dust, dust etc.) from invading to plemum from negative pressure chamber.Therefore, can further suppress foreign matter and in plemum, invade the lifting that realizes cleanliness.
And preferred plemum can remain inside 1st air pressure higher than atmospheric pressure.When plemum internal ratio atmospheric pressure is high, can make the pressure differential of negative pressure chamber and plemum become big, can prevent that foreign matter from sneaking into from the outside of plemum.
The hot cell also can be possesses the structure of filter of removing foreign matter the booster mechanism that promotes the pressure in the plemum and the gas in being directed in plemum.According to the hot cell of this structure, can promote pressure in the plemum by booster mechanism, the gas of removing foreign matter by filtrator can be imported in the plemum.
Preferably the gas that imports in the plemum imports from the upper side of plemum, and the gas of deriving from plemum is derived from the lower side of plemum.By importing gas from upper side, and derive gas from lower side, can in plemum, form from above downwards gas flow.The foreign matter of plemum is kicked up just can discharge outside plemum.
The invention effect
So can realize the lifting of the cleanliness in the plemum (synthetic chamber) according to hot cell of the present invention.
Description of drawings
Fig. 1 is the sectional view in the related hot cell of embodiments of the present invention, the cross section of expression and parallel sided.
Fig. 2 is the sectional view in the related hot cell of embodiments of the present invention, expression and positive parallel cross section.
Fig. 3 is the front cross-sectional view of hot cell main body, is the figure of the configuration of expression inside door and wicket.
Among the figure: the 10-hot cell, 11-hot cell main body, the positive door of 12-(radioactive ray shielding wall), 13-back face wall (radioactive ray shielding wall), 14-top wall (radioactive ray shielding wall), 15-underside wall (radioactive ray shielding wall), 16-sidewall (radioactive ray shielding wall), 21-plemum (synthetic chamber), 22-negative pressure chamber, the 31-cleaning unit, 100-radiopharmaceutical agent disposal plant.
Embodiment
Below, the preferred implementation to hot cell involved in the present invention describes with reference to the accompanying drawings.In addition, in the description of the drawings, the additional identical symbol of identical or corresponding important document is omitted repeat specification.And the position relation that waits up and down is based on the position relation of accompanying drawing.
The hot cell 10 of Figure 1 and Figure 2 possesses the hot cell main body 11 that is box-shaped.Hot cell main body 11 has: positive door (shutter door) 12, the front openings portion of switching hot cell main body 11; Back face wall 13, its for the positive door 12 opposed wall bodies that dispose; Top wall 14, it is the wall body that is disposed at end face; Underside wall 15, it is the wall body that is disposed at the bottom surface; And pair of sidewalls 16, it is the wall body that is disposed at the side.In addition, in the following description, when there is no need to distinguish back face wall 13, top wall 14, underside wall 15 and sidewall 16, be sometimes referred to as wall body 13～16.
The positive door 12 of formation hot cell main body 11 and wall body 13～16 are formed by the radioactive ray shielding wall of the transmission that suppresses radioactive ray.The radioactive ray shielding wall is for example formed by lead.Also can suitably change the material of radioactive ray shielding wall according to being contained in radiomaterials in the hot cell main body 11.
The front openings portion of hot cell main body 11 is used for taking out the object 100 of putting into the inside that is contained in hot cell main body 11.Object 100 as the inside that is contained in hot cell main body 11, for example can enumerate the synthesizer that radiomaterial is labeled as other materials (be basic synthesizing radioactive medicament with radiomaterial), the quality calibrating installation of the quality of calibrating radiopharmaceutical agent etc.Below, these objects are called " radiopharmaceutical agent disposal plant (radiomaterial disposal plant) ".
The peristome of hot cell main body 11 does not limit and is formed at face side, can be formed at side, end face, bottom surface, the back side yet.And peristome also can form a plurality of.Positive door 12 is formed by the radioactive shield wall.
Positive door 12 for example be fixed in the end of the face side that is arranged on sidewall 16 hinge (not shown) and and supporting for swinging.Positive door 12 becomes the structure with pair of right and left door.As long as positive door 12 can open and close peristome, the wall body that forms door can be also can swinging of sliding.In addition, positive 12 can be the area that equates with opposed back face wall 13, also can be the door that covers the peristome littler than back face wall 13 areas.Hot cell 10 also can be to possess face wall, and possesses the structure of the positive door that the peristome that is formed at this face wall is opened and closed.
Be formed with the plemum 21 that inside can be remained the 1st air pressure and the negative pressure chamber 22 that inside is remained 2nd air pressure lower than the 1st air pressure in the hot cell main body 11.Preferred the 1st air pressure is the pressure higher than atmospheric pressure.
The peristome of plemum 21 is used for taking-up and puts into the radiopharmaceutical agent disposal plant 100 that is contained in inside.The peristome of plemum 21 does not limit and is formed at face side.The peristome of plemum 21 is formed at the position corresponding with the peristome of hot cell main body 11.In the present embodiment, because the peristome of hot cell main body 11 is disposed at face side, so the peristome of plemum 21 also is formed at the face side of plemum 21.As long as inside door 23 can open and close the peristome of plemum 21, the wall body that forms door can slide, and also can swing.Inside door 23 can be formed by the radioactive shield wall, also can be formed by the wall body of transmission radioactive ray.
Negative pressure chamber 22 more forms by peristome (the positive door 12) side of hot cell main body 11 than plemum 21.Negative pressure chamber 22 is formed by the end of the face side of the end of the face side of the end of the face side of positive door 12, inside door 23, top wall 14, underside wall 15 and pair of sidewalls 16.Negative pressure chamber 22 is disposed between the peristome (positive door 12) and plemum 21 of hot cell main body 11, inside can be remained the 2nd air pressure low and that force down than atmosphere than the 1st air pressure.
And hot cell 10 possesses the cleaning unit 31 that imports the air that cleanliness promote in the plemum 21 and with the exhaust unit 41 that discharge 10 outside to the hot cell of the gas (air) in the negative pressure chamber 22.The hot cell 10 of present embodiment possesses a plurality of plemums 21 is arranged.The plemum 21 that is arranged at upper layer side is provided with cleaning unit 31.
And, also can be at positive door 12 and inside door 23 peristome to be set, and possess the structure of the wicket 23b that opens and closes this peristome.As shown in Figure 3, also can be for example to be provided with wicket 23b at the inside door 23 of lower floor, be not provided with the structure of wicket 23b at the inside door 23 on upper strata.In addition, though the wicket of not shown positive door 12, it is arranged at the position corresponding with the wicket 23b of inside door 23.Open and close wicket 23b by not opening and closing positive door 12 and inside door 23, can suppress the pressure in the plemum 21, the influence of cleanliness, and the taking-up of carrying out the article in the plemum 21 is put into or the operation of the radiopharmaceutical agent disposal plant 100 of plemum 21 etc.
Then, the effect to hot cell 10 describes.In the plemum 21 in hot cell 11, for example dispose synthesizer.The air that cleanliness promote by cleaning unit 31 removal foreign matters imports in the plemum 21.Remain the 1st air pressure in the plemum 21.The 1st air pressure for example is the pressure higher than atmospheric pressure.
The air that exhaust attracts in the negative pressure chamber 22 with fan blower 43.Remain 2nd air pressure lower and lower than atmospheric pressure than the 1st air pressure in the negative pressure chamber 22.Air in the plemum 21 by be formed at inside door 23 around gap etc., flow in the negative pressure chamber 22 (plemum 21 is communicated with negative pressure chamber 22).Air in the negative pressure chamber 22 is deflated with fan blower 43 and attracts, and flows and discharge outside hot cell 10 in gas outlet 42.And, by be formed at positive door 12 around gap etc., the air of invading in the negative pressure chamber 22 can not invade in the plemum 21 and by exhaust unit 41 exhaust outside hot cell 10.The processing that 10 air of discharging for example are sent to exhaust equipment and are scheduled to by active carbon filter from the hot cell.
Radiopharmaceutical agent disposal plant 100 is disposed at PET(Positron Emmision Tomography) radiopharmaceutical agent that uses in the diagnosis etc., because this radiopharmaceutical agent is to patient infusion, therefore requirement reduces sneaking into of foreign matter as far as possible.Therefore, the chamber that is provided with radiopharmaceutical agent disposal plant 100 in hot cell 10 preferably suppresses to have from its outside the intrusion of foreign matter as far as possible.
In the hot cell 10 of present embodiment, can for example cleanliness of grade 100 will be maintained in the plemum 21.If compared with plemum 21 more by positive door 12(peristome) side possesses the structure of negative pressure chamber 22, then can reduce the misgivings that radiomaterial flows out by peristome from negative pressure chamber 22.
And, because the inside of plemum 21 remains 1st air pressure higher than atmospheric pressure, can prevent reliably that therefore foreign matter from 10 outside invading from the hot cell in plemum 21.
And in the hot cell 10 of present embodiment, the air that imports in the plemum 21 imports from the upper side of plemum 21, and the air of deriving from plemum 21 is derived from the lower side of plemum 21.By importing air from upper side and deriving air from lower side, can in plemum 21, form from above downwards gas flow.For example, even when in plemum 21, having foreign matter, can not kick up foreign matter yet and can outside plemum 21, discharge.
More than, embodiments of the present invention are had been described in detail, but the present invention is not limited to above-mentioned embodiment.For example, the pressure (the 1st air pressure) in the plemum is not limited to the situation higher than atmospheric pressure, can be atmospheric pressure, also can be the pressure lower than atmospheric pressure.
And the hot cell also can be the structure that does not possess cleaning unit (booster mechanism (fan etc.), filtrator).For example, also can in plemum 21, import air from the container (gas bomb etc.) that is filled with the air that cleanliness promote.
In addition, the gases that are directed in the plemum 21 are not limited to air, also can be other gases (for example, inert gas etc.).And, both can import gas from the upper side of plemum 21, for example also can import from lower side or middle part.Can derive gas from the lower side of plemum 21 equally, also can derive from upper side or middle part.For example, also derive the structure of air from the upper side of negative pressure chamber 22.
And booster mechanism is not limited to the fan of cleaning unit 31, also can be other booster mechanisms such as compressor.
And in the above-mentioned embodiment, illustration has the structure that possesses a plurality of plemums 21, but also can be the structure that possesses a plemum 21.And negative pressure chamber 22 can be the negative pressure chamber that shares with respect to a plurality of plemums 21, also can be the structure that possesses negative pressure chamber 22 with each plemum 21 accordingly separately.And, in the above-mentioned embodiment, be formed with the space 22b that is communicated in negative pressure chamber 22 at the bottom surface side of plemum 21, but also can be the structure that is not formed with space 22b at the bottom surface side of plemum 21.
In addition, if radiopharmaceutical agent disposal plant 100 is the quality calibrating installation of the radiopharmaceutical agent of the quality of calibrating radiopharmaceutical agent, then can not discard and carries out radiopharmaceutical agent that quality examines and determine and directly to patient infusion.In the quality calibrating of in the past radiopharmaceutical agent, to manually being carried out by the staff with the drip operation of radiopharmaceutical agent of reagent bottle as the sterility test of its 1 operation.Because staff's hand invades in the hot cell, so sneaks into foreign matter easily in the hot cell.Therefore, the radiopharmaceutical agent that uses in the quality calibrating can't go out of use for patient infusion uses.But, recently, require the robotization of the quality calibrating of radiopharmaceutical agent.Automatically carry out the quality calibrating by machinery, and, by using as hot cell of the present invention, can suppress foreign matter and sneak in the radiopharmaceutical agent that carries out the quality calibrating, and can will carry out the radiopharmaceutical agent of quality calibrating directly to patient infusion.
The application advocates the right of priority based on the Japanese patent application of on February 22nd, 2012 application 2012-036427 number.The full content of its application is applied in this instructions by reference.
Claims (5)
1. hot cell, it has the radioactive ray shielding wall that suppresses the radioactive ray transmission, and this hot cell comprises:
The hot cell main body, it is the case that is formed by described radioactive ray shielding wall;
Plemum is formed in the main body of described hot cell, inside can be remained the 1st air pressure, and accommodate the radiopharmaceutical agent disposal plant;
Negative pressure chamber is formed in the main body of described hot cell, inside can be remained the 2nd air pressure low and that force down than atmosphere than described the 1st air pressure.
2. hot cell as claimed in claim 1, wherein,
Described negative pressure chamber is disposed between the peristome and described plemum of described hot cell main body.
3. hot cell as claimed in claim 1 or 2, wherein,
Described plemum can remain inside described 1st air pressure higher than atmospheric pressure.
4. hot cell as claimed in claim 1 or 2, wherein,
This hot cell also possesses: booster mechanism rises the pressure in the described plemum; And
Filtrator is removed foreign matter the gas in importing to described plemum.
5. hot cell as claimed in claim 1 or 2, wherein,
Import to the interior gas of described plemum from the upper side importing of described plemum,
The gas of deriving from described plemum is derived from the lower side of described plemum.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012036427 | 2012-02-22 | ||
| JP2012-036427 | 2012-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103295658A true CN103295658A (en) | 2013-09-11 |
| CN103295658B CN103295658B (en) | 2017-04-26 |
Family
ID=49096382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310058035.6A Active CN103295658B (en) | 2012-02-22 | 2013-02-22 | Hot cell |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6121190B2 (en) |
| CN (1) | CN103295658B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105719712A (en) * | 2016-02-02 | 2016-06-29 | 中国原子能科学研究院 | Sandwich-type inert gas shielding hot chamber |
| CN107126907A (en) * | 2016-02-26 | 2017-09-05 | 南京中硼联康医疗科技有限公司 | Pharmaceutical synthesis device |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102088349B1 (en) * | 2018-07-03 | 2020-03-12 | 영남대학교 산학협력단 | Hot cell |
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| JP3410389B2 (en) * | 1999-05-13 | 2003-05-26 | 日科ミクロン株式会社 | Clean room |
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| JP4811951B2 (en) * | 2007-08-23 | 2011-11-09 | 独立行政法人日本原子力研究開発機構 | Cutting and opening device for sealed container containing activated metal material and radioactive gas |
| US8915984B2 (en) * | 2010-06-18 | 2014-12-23 | Airex Co., Ltd | Isolator device |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5549512A (en) * | 1994-11-30 | 1996-08-27 | Lucent Technologies Inc. | Minienvironment for hazardous process tools |
| JPH08338897A (en) * | 1995-06-13 | 1996-12-24 | Ebara Kogyo Senjo Kk | Glove box |
| JP3683744B2 (en) * | 1999-06-04 | 2005-08-17 | 株式会社エアレックス | Cleaner maintenance device for isolator device |
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| CN1702778A (en) * | 2004-05-25 | 2005-11-30 | 住友重机械工业株式会社 | RI labelled composition synthesis system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105719712A (en) * | 2016-02-02 | 2016-06-29 | 中国原子能科学研究院 | Sandwich-type inert gas shielding hot chamber |
| CN107126907A (en) * | 2016-02-26 | 2017-09-05 | 南京中硼联康医疗科技有限公司 | Pharmaceutical synthesis device |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6121190B2 (en) | 2017-04-26 |
| JP2013200302A (en) | 2013-10-03 |
| CN103295658B (en) | 2017-04-26 |
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