CN103272021A - Traditional chinese medicine extract - Google Patents
Traditional chinese medicine extract Download PDFInfo
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- CN103272021A CN103272021A CN2013101207033A CN201310120703A CN103272021A CN 103272021 A CN103272021 A CN 103272021A CN 2013101207033 A CN2013101207033 A CN 2013101207033A CN 201310120703 A CN201310120703 A CN 201310120703A CN 103272021 A CN103272021 A CN 103272021A
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Abstract
The invention relates to a natural pharmaceutical composition and its preparation method and use in preparation of drugs for reducing toxicity and improving treatment effects in cancer chemotherapy. The natural pharmaceutical composition is traditional Chinese medicine extract and is composed of milkvetch root-haw water-decoction condensation extract, milkvetch root polysaccharide, and total flavonoids of haw according to a ratio of 2-8: 5-8: 1-4. The natural pharmaceutical composition has excellent effects of treating cancer chemotherapy-related diarrhoea and can improve cancer chemotherapy effects.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to a kind of natural drug composition of being made up of Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones, the preparation method of this natural drug composition and this natural drug composition are for the preparation of reducing cancer chemotherapy dependency diarrhoea and treatment of cancer being played purposes in the medicine of potentiation.
Background technology
Malignant tumor is current harm humans existence, one of healthy principal disease, and its treatment means comprises operation, chemotherapy, radiotherapy, Chinese medicine, and the effect of chemotherapeutic treatment tumor is particularly outstanding.Chemotherapeutic no matter singly with or unite with all causing toxicities such as patient, diarrhoea, diarrhoea makes the chemotherapy dependency suffer from diarrhoea again behind the chemotherapy of tumors.Emerging and applying along with chemotherapeutics such as 5-fluorouracil, taxanes, hydroxy camptothecin, irinotecan, xeloda etc. in recent years, the incidence rate of chemotherapy dependency diarrhoea improves year by year, and if do not carry out active treatment, easily cause patient's dehydration, malnutrition, serum electrolyte disorder, acid base imbalance etc., it is unfavorable greatly not only the rehabilitation of body to be brought, also bring certain difficulty to CC, therefore effective treatment of chemotherapy dependency diarrhoea has been become the important component part of tumor patient wholistic therapy.
Chemotherapy dependency diarrhoea is with regard to its clinical manifestation, surely belongs to the Chinese medicine category of " having loose bowels ", and Chinese medicine attracts people's attention for the research of having loose bowels, but at present still unmatchful anticancer disease chemotherapy have the Chinese patent medicine of alleviating diarrhoea and potentiation.Therefore, research and develop a kind of high-efficiency low-toxicity, cheap, the natural Chinese medicine that can be used for alleviating cancer chemotherapy dependency diarrhoea and playing the chemotherapeutic sensitivity effect that is easy to promote becomes clinical problem demanding prompt solution.
The Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, and the Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus effect.Be used for the chronic diarrhea proctoptosis.Fructus Crataegi can help digestion long-pending; Change the stasis of blood that stagnates, cure mainly eating accumulation, dysentery.In recent years, the Radix Astragali and Fructus Crataegi antitumaous effect are confirmed, the inventor is through research and the experiment of each a large amount of formula proportion, obtained optimal drug ratio compositions of the present invention at last, it is the compositions of novelty, and proved that it has fabulous curative effect and can play potentiation to cancer chemotherapy simultaneously cancer chemotherapy dependency diarrhoea, has finished the present invention thus.
Summary of the invention
A kind of natural drug composition provided by the invention, by Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones by weight in 2-8: the ratio of 5-8: 1-4 is formed.
Above-mentioned natural drug composition, wherein the usage ratio of Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones is 2: 2: 1.
Wherein, Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides can be by well known to a person skilled in the art the conventional method acquisition of purifying, and adopt these compositions that conventional method obtains or the natural drug of the present invention that adopts the commercial one-tenth of buying to be grouped into all can obtain identical curative effect.
Preferably, Radix Astragali Fructus Crataegi water boiling concentration preparation method of extract is in the above-mentioned natural drug composition:
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got the Radix Astragali, Fructus Crataegi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
The preparation method of astragalus polysaccharides is in the above-mentioned natural drug composition:
The Radix Astragali is pulverized, and with drying behind the 95% ethanol extraction saponin, adds distilled water, dropwise add saturated limewater, adjust pH leaves standstill 10min with the moistening material, microwave radiation 1min, radiation 1min again behind the 1min at interval, filter extracting solution, repeat aforesaid operations 2-3 time, merge extractive liquid, concentrates, regulate pH=7 with 10% hydrochloric acid, add 95% ethanol, wash out polysaccharide, filter, washing with alcohol is drying to obtain.
The Fructus Crataegi total flavones preparation method is in the above-mentioned natural drug composition:
Get haw pulp, with 60% alcohol reflux 2 times, each 1.5h, merge extractive liquid, reclaims ethanol, gets extractum, and extractum adds an amount of distilled water respectively, stirs evenly, and adds CaCl
21g, standing over night, centrifugal, collect supernatant, transfer pH to 7～8 with ammonia, add in the macroporous adsorptive resins, regulate flow velocity 5mL/min, with distilled water flush away impurity, be the mobile phase desorption with ethanol, reclaim ethanol, namely.
The present invention also provides the preferred manufacturing procedure of this natural drug composition, comprising:
(1) preparation of Radix Astragali Fructus Crataegi water boiling concentration extract
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got the Radix Astragali, Fructus Crataegi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
(2) preparation of astragalus polysaccharides
The Radix Astragali is pulverized, and with drying behind the 95% ethanol extraction saponin, adds distilled water, dropwise add saturated limewater, adjust pH leaves standstill 10min with the moistening material, microwave radiation 1min, radiation 1min again behind the 1min at interval, filter extracting solution, repeat aforesaid operations 2-3 time, merge extractive liquid, concentrates, regulate pH=7 with 10% hydrochloric acid, add 95% ethanol, wash out polysaccharide, filter, washing with alcohol is drying to obtain.
(3) Fructus Crataegi total flavones preparation
Get haw pulp, with 60% alcohol reflux 2 times, each 1.5h, merge extractive liquid, reclaims ethanol, gets extractum, and extractum adds an amount of distilled water respectively, stirs evenly, and adds CaCl
21g, standing over night, centrifugal, collect supernatant, transfer pH to 7～8 with ammonia, add in the macroporous adsorptive resins, regulate flow velocity 5mL/min, with distilled water flush away impurity, be the mobile phase desorption with ethanol, reclaim ethanol, namely.
(4) choose Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones in proportion, evenly mix, namely.
The preparation method of above-mentioned natural drug composition, also comprise: the product that step (4) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
The beneficial effect of natural drug composition of the present invention aspect anti-chemotherapy dependency diarrhoea and inhibition tumor is as follows:
1, natural drug composition of the present invention causes the diarrhea of mouse Study of model to show at irinotecan: the diarrhoea reaction for the irinotecan induced mice has tangible antagonism.
2, proved that this natural drug composition can strengthen chemotherapeutics to the inhibitory action of tumor, adopted mouse tumor model, observed this natural drug composition and cyclophosphamide combined to the inhibitory action of mouse interior tumor.Studies show that: this natural drug composition can obviously increase cyclophosphamide for the inhibitory action of tumor.
3, the inventor is originally with Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones make up, and by the consumption proportion between definite these components of a large amount of experiments, make said composition bring into play synergism, pass through our experimentation repeatedly, ratio between each component of natural drug composition of the present invention is at 2-8: 5-8: produced unexpected synergism during 1-4, potentiation is obvious, extraordinary effect is played in side effect, especially the usage ratio of each component be 2: 2: 1 o'clock especially obvious, this is that the inventor pays a large amount of creative works and obtains, and those of ordinary skills only can't simply obtain this ratio range and optimum amount ratio by disclosed content.
4, this natural drug composition Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones all can obtain by conventional means, and wherein component such as astragalus polysaccharides can be buied by commerce, and such compositions has the convenience of acquisition, lower-cost effect.This also is the product that has splendid curative effect and higher industrial practicality concurrently that the inventor obtains by a large amount of creative work sides.
The specific embodiment
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and the beneficial effect in diarrhea and antitumor, used.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Radix Astragali Fructus Crataegi water boiling concentration extract
Be 1: 1 or 1-4 according to proportion compatibility: 1 other ratios are got the Radix Astragali, Fructus Crataegi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely.
(2) preparation of astragalus polysaccharides
The Radix Astragali is pulverized, and with drying behind the 95% ethanol extraction saponin, adds distilled water, dropwise add saturated limewater, adjust pH leaves standstill 10min with the moistening material, microwave radiation 1min, radiation 1min again behind the 1min at interval, filter extracting solution, repeat aforesaid operations 2-3 time, merge extractive liquid, concentrates, regulate pH=7 with 10% hydrochloric acid, add 95% ethanol, wash out polysaccharide, filter, washing with alcohol is drying to obtain.
(3) Fructus Crataegi total flavones preparation
Get haw pulp, with 60% alcohol reflux 2 times, each 1.5h, merge extractive liquid, reclaims ethanol, gets extractum, and extractum adds an amount of distilled water respectively, stirs evenly, and adds CaCl
21g, standing over night, centrifugal, collect supernatant, transfer pH to 7～8 with ammonia, add in the macroporous adsorptive resins, regulate flow velocity 5mL/min, with distilled water flush away impurity, be the mobile phase desorption with ethanol, reclaim ethanol, namely.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule preparations of the present invention
Take by weighing Radix Astragali Fructus Crataegi water boiling concentration extract 40mg, astragalus polysaccharides 40mg and the Fructus Crataegi total flavones 20mg of above-mentioned steps preparation respectively, take by weighing starch 395mg, magnesium stearate 5mg simultaneously, evenly mix, be filled to capsule.
(2) preparation of natural drug composition tablet of the present invention
Take by weighing Radix Astragali Fructus Crataegi water boiling concentration extract 40mg, astragalus polysaccharides 40mg and the Fructus Crataegi total flavones 20mg of above-mentioned steps preparation respectively, take by weighing starch 295mg, lactose 100mg simultaneously, evenly mix, with wet granulation, drying, mix with the 5mg magnesium stearate behind the granulate, be pressed into tablet.
Drug effect and pharmacology's data:
Compositions is in following test example: the usage ratio of Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones is 2: 2: 1.The inventor to above-mentioned each composition usage ratio at 2-8: 5-8: the compositions that the multiple proportioning combination in the time of between the 1-4 obtains has been carried out and last identical experiment, find that all the natural drug composition in this amount ranges can obtain good synergism, can play good effect and treatment for cancer is had potentiation cancer chemotherapy dependency diarrhoea.Below be the pharmacodynamics data that preferred embodiment obtains:
Test example 1: the pharmacodynamic study of natural drug composition treatment chemotherapy dependency diarrhoea effect
1, test material
(1) Radix Astragali, Fructus Crataegi is purchased in medical material market.
(2) mice, male, ad lib drinking-water before the experiment.
2, test method:
Mice is divided into 5 groups at random, and 5 every group, the A group is model group, and the B group is Radix Astragali Fructus Crataegi water boiling concentration extract 10g.kg
-1(being equivalent to contain the crude drug amount), the C group is astragalus polysaccharides 10g.kg
-1(being equivalent to contain the crude drug amount), D group car Fructus Crataegi total flavones 10g.kg
-1(being equivalent to contain the crude drug amount), the E group is natural drug composition 10g.kg of the present invention
-1(being equivalent to contain the crude drug amount), irinotecan intraperitoneal injection (75mg/kg), continuous 4 days, copies chemotherapy dependency diarrhoea model at every day 1 time.B, C, D, E group were irritated stomach 8 days with corresponding extract continuously, and mice is placed metabolic cage, spread white filter paper at the bottom of the cage with observation stool situation, and observed mice crissum situation and Mus tail fecal pollution situation, stimulated the anus defecation in conjunction with cotton swab, and every day, observed and recorded was 2 times.Diarrhoea degree standard scoring is as follows: 0 minute: stool is normal or do not have; 1 minute: laxativeness, stool is visible slight wet soft; 2 minutes: the wet and not molding of moderate diarrhoea, stool.And there is slight crissum painted; 3 minutes, severe diarrhoea, watery stool is also painted with the severe crissum.
3, experimental result
Compare with model group, the degree of Radix Astragali Fructus Crataegi water boiling concentration extract group chemotherapy dependency diarrhoea is lower than model group, and natural drug composition group of the present invention diarrhoea incidence rate obviously alleviates.The results are shown in Table 1.
Table 1 present composition is to mice chemotherapy dependency diarrhoea incidence rate and scoring influence
Annotate: a is equivalent to contain the crude drug amount
Test example 2: the pharmacodynamic study of natural drug composition antitumor action of the present invention
1, experiment material
(1) Kunming mouse, body weight 20 ± 2g, ad lib drinking-water before the experiment, 24h natural light irradiation.
(2) cyclophosphamide, the permanent auspicious medical Pharmacy stock Co., Ltd in Jiangsu product.
2, test method:
To mice S
180The inhibition test of sarcoma growth
Employing was gone down to posterity 5-7 days, and well-grown milky ascites is diluted to tumor cell suspension with an amount of physiological saline solution, and cell number is 10
7/ mL, 5 every group, the right axillary fossa subcutaneous vaccination of every Mus 0.2mL (contains oncocyte 2 * 10
6Individual).Inoculation random packet next day, experimental group natural drug composition of the present invention is divided into (200,100mg/mL) two dosage groups, every Mus is irritated stomach 0.5ml, gives cyclophosphamide 10gkg simultaneously
-1D
-1Negative control group gives 0.5mL distilled water; The positive drug group gives cyclophosphamide 10gkg
-1D
-1, successive administration 10 days.The conventional raising, drinking-water, food is not limit.Drug withdrawal next day, mice all takes off cervical vertebra puts to death, and strips subcutaneous solid tumor tumor piece, weighs, and calculates tumor control rate (%) by following formula:
Tumor control rate=(the average tumor of the matched group average tumor of heavy (C)-experimental group heavy (T))/average tumor of matched group heavy (C)
3, result of the test
Natural drug composition of the present invention is low, high dose group all can strengthen the cyclophosphamide agent with to S
180The effect of inhibition degree, especially the strongest with the high dose group effect.(as table 2)
Table 2 natural drug composition of the present invention is to S
180The tumor inhibition effect of mice
Claims (5)
1. natural drug composition that reduces cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation, it is characterized in that said composition by Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones by weight in 2-8: the ratio of 5-8: 1-4 is formed
Wherein Radix Astragali Fructus Crataegi water boiling concentration preparation method of extract is:
Be 1-4 according to proportion compatibility: 1 gets the Radix Astragali, Fructus Crataegi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely;
Wherein the preparation method of astragalus polysaccharides is:
The Radix Astragali is pulverized, and with drying behind the 95% ethanol extraction saponin, adds distilled water, dropwise add saturated limewater, adjust pH leaves standstill 10min with the moistening material, microwave radiation 1min, radiation 1min again behind the 1min at interval, filter extracting solution, repeat aforesaid operations 2-3 time, merge extractive liquid, concentrates, regulate pH=7 with 10% hydrochloric acid, add 95% ethanol, wash out polysaccharide, filter, washing with alcohol is drying to obtain;
Wherein the preparation method of Fructus Crataegi total flavones is:
Get haw pulp, with 60% alcohol reflux 2 times, each 1.5h, merge extractive liquid, reclaims ethanol, gets extractum, and extractum adds an amount of distilled water respectively, stirs evenly, and adds CaCl
21g, standing over night, centrifugal, collect supernatant, transfer pH to 7～8 with ammonia, add in the macroporous adsorptive resins, regulate flow velocity 5mL/min, with distilled water flush away impurity, be the mobile phase desorption with ethanol, reclaim ethanol, namely.
2. natural drug composition as claimed in claim 1 is characterized in that wherein the usage ratio of Radix Astragali Fructus Crataegi water boiling concentration extract, astragalus polysaccharides and Fructus Crataegi total flavones is 2: 2: 1.
3. as the preparation method of the natural drug composition of claim 1 or 2, it is characterized in that this method comprises:
(1) preparation of Radix Astragali Fructus Crataegi water boiling concentration extract
Be 1-4 according to proportion compatibility: 1 gets the Radix Astragali, Fructus Crataegi, 10 times of amount distilled water immersion 1h, heating decocts 1h on the electric furnace that adds asbestos gauge, and silk filters, preserve filtrate, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is mixed, heating is concentrated into small size, ultrafiltration membrance filter adopts 70 ℃ of drying under reduced pressure 36h of vacuum drying oven to get pale brown toner end, namely;
(2) preparation of astragalus polysaccharides
The Radix Astragali is pulverized, and with drying behind the 95% ethanol extraction saponin, adds distilled water, dropwise add saturated limewater, adjust pH leaves standstill 10min with the moistening material, microwave radiation 1min, radiation 1min again behind the 1min at interval, filter extracting solution, repeat aforesaid operations 2-3 time, merge extractive liquid, concentrates, regulate pH=7 with 10% hydrochloric acid, add 95% ethanol, wash out polysaccharide, filter, washing with alcohol is drying to obtain;
(3) preparation of Fructus Crataegi total flavones
Get haw pulp, with 60% alcohol reflux 2 times, each 1.5h, merge extractive liquid, reclaims ethanol, gets extractum, and extractum adds an amount of distilled water respectively, stirs evenly, and adds CaCl
21g, standing over night, centrifugal, collect supernatant, transfer pH to 7～8 with ammonia, add in the macroporous adsorptive resins, regulate flow velocity 5mL/min, with distilled water flush away impurity, be the mobile phase desorption with ethanol, reclaim ethanol, namely;
(4) choose Radix Astragali Fructus Crataegi water boiling concentration extract in proportion, astragalus polysaccharides evenly mixes with Fructus Crataegi total flavones, namely.
4. the preparation method of natural drug composition as claimed in claim 3, also comprise: the product that step (4) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
5. as the purposes of each described natural drug composition of claim 1-2 in preparing the medicine that reduces the reaction of cancer chemotherapy dependency diarrhoea and the treatment cancer is played potentiation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771713A (en) * | 2018-07-17 | 2018-11-09 | 佛山市聚成生化技术研发有限公司 | A kind of decompression fat reducing composition and preparation method thereof |
| CN109363173A (en) * | 2018-10-26 | 2019-02-22 | 内蒙古中健宝生物科技有限公司 | A kind of Milkvetch root composition and Radix Astragali water prepared therefrom and preparation method thereof |
| CN114431382A (en) * | 2021-12-27 | 2022-05-06 | 上海凯宝药业股份有限公司 | Astragalus and haw solid beverage and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166335A (en) * | 2011-03-31 | 2011-08-31 | 青岛大学 | Ginger and long pepper composition as well as preparation method and application thereof in preparation of toxicity reducing and efficacy enhancing medicament in radiotherapy and chemotherapy of cancer |
-
2013
- 2013-03-29 CN CN2013101207033A patent/CN103272021A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166335A (en) * | 2011-03-31 | 2011-08-31 | 青岛大学 | Ginger and long pepper composition as well as preparation method and application thereof in preparation of toxicity reducing and efficacy enhancing medicament in radiotherapy and chemotherapy of cancer |
Non-Patent Citations (2)
| Title |
|---|
| 任美萍等: "黄芪多糖抗肿瘤活性研究", 《中国新药杂志》 * |
| 柳嘉等: "山楂黄酮提取物的抗氧化活性和对癌细胞生长抑制作用", 《食品科学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108771713A (en) * | 2018-07-17 | 2018-11-09 | 佛山市聚成生化技术研发有限公司 | A kind of decompression fat reducing composition and preparation method thereof |
| CN109363173A (en) * | 2018-10-26 | 2019-02-22 | 内蒙古中健宝生物科技有限公司 | A kind of Milkvetch root composition and Radix Astragali water prepared therefrom and preparation method thereof |
| CN114431382A (en) * | 2021-12-27 | 2022-05-06 | 上海凯宝药业股份有限公司 | Astragalus and haw solid beverage and preparation method thereof |
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Application publication date: 20130904 |