CN103251884B - Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating Alzheimer disease as well as a preparation method and application thereof. The traditional Chinese medicine comprises the following components in parts by mass: 15 parts of codonopsis pilosula, 15 parts of astragalus mongholicus, 12 parts of rhizoma polygonati, 6 parts of polygonum multiflorum, 10 parts of curcuma aromatica, 8 parts of rhizoma acori graminei, 10 parts of ligusticum wallichii and 8 parts of earthworm. The method comprises the following steps of: adding the curcuma aromatica, the rhizoma acori graminei and the ligusticum wallichii into deionized water, heating for distilling and extracting volatile oil, dehydrating the volatile oil, clathrating with beta-cyclodextrin and drying at low temperature; collecting a distilled water solution with another vessel, adding the codonopsis pilosula, the astragalus mongholicus, the rhizoma polygonati, the polygonum multiflorum and earthworm into water, decorating, mixing decoctions, filtering to obtain filtrate, mixing the filtrate with the distilled water solution, concentrating to obtain concentrate, adding 95% ethanol to the concentrate to ensure that the alcohol precipitation concentration is 60%, fully stirring, standing for 24-48 hours, filtering to obtain filtrate, recovering ethanol from the filtrate, concentrate the filtrate subjected to ethanol removal to form thick paste and performing microwave drying on the thick paste to form a dry extract; and crushing the dry extract, adding a defined amount of dextrin or starch, performing wet granulation, drying and granulation, adding a volatile oil clathrate compound and uniformly mixing. By adopting methods of invigorating spleen and kidney, eliminating phlegm and dispersing blood stasis, the brain premature senility and brain aging are prevented and intervened, thereby delaying the development of the Alzheimer disease, improving the clinical symptoms and improving the life quality of patients.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of Alzheimer, particularly relate to a kind of Chinese medicine for the treatment of Alzheimer and its preparation method and application.
Background technology
Alzheimer (Alzheimer disease, AD) is a kind of disease being changed to feature with acquired intellectual deterioration and behavior personality.When unconscious obstacle, there are memory and cognitive function disorder, with speech, visual space technical ability, emotion or personality changes, and affect its social activity.Patient's onset is hidden, and early symptom shows as nearly hypomnesis, personality changes, and intelligence declines to some extent, and spatial orientation is bad, often go astray from the group, fail to see homeward journey or initiative minimizing, labile affect, but daily life still can keep.Further develop, cognitive decrease, occur aphasia, agnosia, and can occur focal neurological signs, daily life can not be taken care of oneself, and often has shameless behavior, ethics behavior change, even occurs auditory hallucination, photis, vain hope, manic or depressive symptom.Then there is comprehensive disturbance of intelligence in late period, patient lies in bed, without autonomic movement, keeps silent without language or fragmentation of giving ambiguous stayements, and can't take care of oneself at all, finally dies from the complication such as pulmonary infection, urinary system infection, pressure ulcer more.
Because the cause of disease of Alzheimer and pathogenesis are still not clear, there is no effect method so far and reverse and stop disease progression.Medicine such as cholinesterase inhibitor, antioxidant, anti-inflammatory drug, the suppression amyloid of current treatment Alzheimer form medicine, estrogen, nerve growth factor etc., all intervene for a certain pathological characteristic link of primary disease, still can not stop or delay the course of disease of Alzheimer, effect is all undesirable.
Summary of the invention
The object of this invention is to provide a kind of energy stop or delay the course of disease of Alzheimer, the Chinese medicine of effective treatment Alzheimer and its preparation method and application.
The object of the invention is to be achieved through the following technical solutions:
The Chinese medicine for the treatment of Alzheimer of the present invention, comprises following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima.
The preparation method of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention, comprises step:
First, by Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three taste medical material, add 10 ~ 15 times amount deionized waters, heating distillating extracting oil, dewaters the volatile oil anhydrous sodium sulfite of extraction, then uses beta-cyclodextrin inclusion compound, cold drying.The another device of aqueous solution after distillation is collected, for subsequent use;
Then, by Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima gomi herbs, 2 ~ 3 times are decocted with water, collecting decoction, filters, and filtrate and the aqueous solution after distilling merge, concentrated, concentrated solution adds 95% ethanol, makes alcohol precipitation concentration be 60%, abundant stirring, leave standstill 24 ~ 48 hours, filter, filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, adds appropriate dextrin or starch, wet granulation, drying, granulate, add above-mentioned volatile oil clathrate compound, mixing.
The application of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention, is used for the treatment of Alzheimer, and every daily dose is 84 grams of crude drug.
As seen from the above technical solution provided by the invention, Chinese medicine of the treatment Alzheimer that the invention process provides and its preparation method and application, adopt strengthening spleen, tonifying kidney, eliminating phlegm blood stasis dispelling method, can prevent and intervene cerebral senilism, brain aging, thus delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality.
Detailed description of the invention
To be described in further detail the invention process below.
The Chinese medicine for the treatment of Alzheimer of the present invention, its preferably detailed description of the invention be:
Comprise following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima.
Each crude drug by proportion by weight is:
Radix Codonopsis 15 mass parts, the Radix Astragali 15 mass parts, Rhizoma Polygonati 12 mass parts, Radix Polygoni Multiflori 6 mass parts, Radix Curcumae 10 mass parts, Rhizoma Acori Graminei 8 mass parts, Rhizoma Chuanxiong 10 mass parts, Pheretima 8 mass parts.
The preparation method of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention, its preferably detailed description of the invention be:
Comprise step:
First, by Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three taste medical material, add 10 ~ 15 times amount deionized waters, heating distillating extracting oil, dewaters the volatile oil anhydrous sodium sulfite of extraction, then uses beta-cyclodextrin inclusion compound, cold drying.The another device of aqueous solution after distillation is collected, for subsequent use;
Then, by Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima gomi herbs, 2 ~ 3 times are decocted with water, collecting decoction, filters, and filtrate and the aqueous solution after distilling merge, concentrated, concentrated solution adds 95% ethanol, makes alcohol precipitation concentration be 60%, abundant stirring, leave standstill 24 ~ 48 hours, filter, filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, adds appropriate dextrin or starch, wet granulation, drying, granulate, add above-mentioned volatile oil clathrate compound, mixing.
Finally make capsule.
The application of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention, its preferably detailed description of the invention be:
Be used for the treatment of Alzheimer, every daily dose is 84 grams of crude drug.
The present invention develops according to the clinical experience that classical Chinese medicine is theoretical and long-term and goes out, by dissecting the etiology and pathogenesis of primary disease, think that deficiency of spleen and stomach is onset of Alzheimer disease basis, expectorant stasis blocking is closed, the clear key that key is covered, dysfunction of the mind is its morbidity, to Alzheimer deficiency of spleen and stomach, expectorant stasis of blood interlocking type clear curative effect.
The traditional Chinese medical science is thought, kidney governing bones store essential substances, and raw marrow fills brain, " the brain being the house of mentality ", " sudden inspiration is remembered at brain not at the heart "; The spleen being the foundation of acquired constitution, source of generating QI and blood, the pivot of the defeated cloth of body fluid, ascending or descending movement of vital Qi, and the generation of brains and god all derives from the essence of water and grain day after tomorrow.Self hypofunction of generation and internal organs that expectorant is turbid is relevant, concerns spleen kidney two especially dirty, and this shows more obvious in patients with Alzheimer disease.If old, positive QI-insufficiency, deficiency of spleen and stomach, the insufficiency of the spleen weary source of then QI and blood, deficiency of vital energy insufficiency of blood, " deficiency of vital energy deficiency pushes away blood, then blood must have the stasis of blood ", blood stagnant in cerebral venation syndrome, makes us forgetful.Expectorant is turbid formed with blood stasis after, normal knot for suffer from., there is more complicated pathological change in reciprocal causation, causes aggravation then, touching difficulty heal.Deficiency of spleen and stomach, the expectorant stasis of blood hands over resistance, and hoodwinking the basic pathogenesis that key is clearly Alzheimer, is also the key point of clinical treatment.The present invention is according to theory of Chinese medical science and for many years to the understanding of Alzheimer pathogen and pathology of tcm, from traditional Chinese medical science organic conception, develop the present invention, adopt strengthening spleen, tonifying kidney, eliminating phlegm blood stasis dispelling method, can prevent and intervene cerebral senilism, brain aging, thus delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality.
Medicine of the present invention is capsule formulation.
Zoopery example:
Adopt amyloid-beta lateral ventricle of rat brain to inject also coupling transforming growth factors β1 intracerebral injection and produce existing rat behavior change (learning memory disorder), there is again the experimental Alzheimer's disease rat model of typical pathologic (amyloid-beta deposition speckle) and Neurobiochemistry feature, carry out the pharmacodynamic study of above-mentioned Chinese medicine on this rat model learning and memory and cerebral cortex and the impact of hippocampal formation district cholinergic neurotransmitter accordingly, (confirmed by Behavior test and pathological observation) after modeling success, start administration, two groups give rat aqueous solution gavage of the present invention respectively, normal group, model group all gives isometric normal saline gavage, and matched group gavage piracetam suspension, continuous 28 days.Application water maze method and darkness avoidance test determination experiment Alzheimer disease model rat spatial discrimination ability of learning and memory (average latency) and passive avoidance response (bright room stop rate), its rat model cerebral cortex of measured by radioimmunoassay and hippocampal formation district acetyl choline content, choline acetylase and acetylcholine esterase active.Result: experimental Alzheimer disease model rat prolongs with after natural law; water average latency of getting lost obviously increases; bright room stop rate significantly declines; rat model cerebral cortex and hippocampal formation district acetyl choline content reduce; choline acetylase activity decrease; acetylcholine esterase active raises, and compare with matched group, difference has significant.The present invention can shorten experimental model rat water and to get lost average latency; increase bright room stop rate; improve rat model cerebral cortex and hippocampal formation district acetyl choline content and choline acetylase active; reduce acetylcholine esterase active; compare with model group or piracetam matched group, difference has significant.
Conclusion: the present invention obviously improves experimental Alzheimer disease model learning and memory in rats ability by regulating brain Cholinergic neurotransmitter.
Treat patients with Alzheimer disease by the present invention, following effect can be reached:
One, good drug efficacy, evident in efficacy.Radix Codonopsis spleen reinforcing stomach reinforcing in side, gas in strong fortune, tonification is congenital; Rhizoma Polygonati can mend vital essence, beneficial marrow to grow the day after tomorrow, and but it grows greasy property to obtain Radix Codonopsis, Rhizoma Acori Graminei, and the raw wet anxiety of helpless expectorant, for controlling the key medicine of asthenia of both the spleen and kidney; Rhizoma Acori Graminei energy " comfortable gas, the smooth mind, happy mood; beneficial will " (" fragrant celebrating hall random notes "), and can " happy hole, logical nine orifices, improve visual and auditory acuity, go out sound, always get the power of Xin Wenli key " (" herbal classic fits source "), cover product first of clear key for controlling expectorant; Rhizoma Chuanxiong acrid in the mouth, for " the gas medicine in blood " (Compendium of Material Medica) and promoting flow of QI and blood.Rhizoma Acori Graminei joins Rhizoma Chuanxiong, an eliminating phlegm, a blood stasis dispelling, and make key open the stasis of blood expectorant that falls apart and disappear, mind is recovered lost hearing, and Rhizoma Chuanxiong benefaction QI and blood, light clear upper ease, the up high mountain peak of priming power, leads his medicine and to go directly disease institute, is the conventional guiding drug of encephalopathy.All medicines share, and play the effect of tonifying speen and tonifying kidney, eliminating phlegm blood stasis dispelling, brain-strengthening of having one's ideas straightened out altogether.The research of the present invention to Alzheimer achieves certain effect, because of the globality of " monarch, minister, help, make " multilayer system of its composition structure, effective ingredient acts on the links of primary disease respectively, not only can assist human righteousness, regulate whole body functional status, improve brain function, and can righting Eradicates evil, treating both the principal and secondary aspects of a disease, and because of embodied low toxic and side effects, the advantage of display the present invention uniqueness in treatment Alzheimer.
Two, Chinese medicine compatibility composition of the present invention rationally, is applicable to Alzheimer deficiency of spleen and stomach, expectorant stasis of blood interlocking type patient, can prevents and intervene cerebral senilism, brain aging, thus delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality, patient compliance is good.
Specific embodiment:
The Chinese medicine for the treatment of Alzheimer, its Raw is by following weight proportion composition:
Radix Codonopsis (15g), the Radix Astragali (15g), Rhizoma Polygonati (12g), Radix Polygoni Multiflori (6g), Radix Curcumae (10g), Rhizoma Acori Graminei (8g), Rhizoma Chuanxiong (10g), Pheretima (8g), prescription one daily dose: 84 grams.
Preparation process is:
(1) by Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three taste medical material in prescription, add 10 ~ 15 times amount deionized waters, heating distillating extracting oil, dewaters the volatile oil anhydrous sodium sulfite of extraction, then uses beta-cyclodextrin inclusion compound, cold drying.The another device of aqueous solution after distillation is collected; (2) by Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima gomi herbs in prescription, 2 ~ 3 times are decocted with water, collecting decoction, filter, filtrate and the aqueous solution after distilling merge, concentrated, concentrated solution adds 95% ethanol, make alcohol precipitation concentration be 60%, fully stir, leave standstill 24 ~ 48 hours, filter, filtrate recycling ethanol, is condensed into thick paste, and microwave drying becomes dry extract;
(3) pulverized by dry extract, add appropriate dextrin or starch, wet granulation, drying, granulate, add above-mentioned volatile oil clathrate compound, mixing, incapsulates.
The present invention, compared with the mode of prior art, has following at least one advantage:
1, good drug efficacy, improves learning and memory and cognitive function, and effect is clear and definite.
2, compared with Western medicine, multi-level, multipath intervenes elderly brain functional disorder, improves Alzheimer clinical symptoms, improves patients ' life quality, without obvious toxicity, and can long-term taking.
3, easy to use, effective.
The above; be only the present invention's preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (3)
1. treat a Chinese medicine for Alzheimer, it is characterized in that, be made up of following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima;
Each crude drug by proportion by weight is:
Radix Codonopsis 15 mass parts, the Radix Astragali 15 mass parts, Rhizoma Polygonati 12 mass parts, Radix Polygoni Multiflori 6 mass parts, Radix Curcumae 10 mass parts, Rhizoma Acori Graminei 8 mass parts, Rhizoma Chuanxiong 10 mass parts, Pheretima 8 mass parts.
2. a preparation method for the Chinese medicine for the treatment of Alzheimer according to claim 1, is characterized in that, comprise step:
First, by Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three taste medical material, 10 ~ 15 times amount deionized waters are added, heating distillating extracting oil, dewaters the volatile oil anhydrous sodium sulfite of extraction, then uses beta-cyclodextrin inclusion compound, cold drying, the another device of the aqueous solution after distillation is collected, for subsequent use;
Then, by Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima gomi herbs, 2 ~ 3 times are decocted with water, collecting decoction, filters, and filtrate and the aqueous solution after distilling merge, concentrated, concentrated solution adds 95% ethanol, makes alcohol precipitation concentration be 60%, abundant stirring, leave standstill 24 ~ 48 hours, filter, filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, adds appropriate dextrin or starch, wet granulation, drying, granulate, add above-mentioned volatile oil clathrate compound, mixing.
3. the preparation method of the Chinese medicine for the treatment of Alzheimer according to claim 2, is characterized in that, finally make capsule.
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| JP2016088877A (en) * | 2014-11-04 | 2016-05-23 | Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 | Tau protein production promoter, therapeutic and preventive agent of diseases attributed to lack of tau protein, and therapeutic/prophylactic food compositions |
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| CN104547120A (en) * | 2014-12-18 | 2015-04-29 | 黑龙江儒泰生物制药有限责任公司 | Traditional Chinese medicine composition for treating alzheimer disease, as well as preparation method and application thereof |
| CN104587411A (en) * | 2015-02-11 | 2015-05-06 | 田胜硕 | Traditional Chinese medicine preparation for treating pick disease, and preparation method |
| CN109999155B (en) * | 2019-05-06 | 2021-07-30 | 孟胜喜 | Traditional Chinese medicine composition for treating Alzheimer disease and preparation method thereof |
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| CN102335404A (en) * | 2011-10-12 | 2012-02-01 | 成都绿迪科技有限公司 | Oral Chinese medicinal composition for treating senile dementia |
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| JP2016088877A (en) * | 2014-11-04 | 2016-05-23 | Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 | Tau protein production promoter, therapeutic and preventive agent of diseases attributed to lack of tau protein, and therapeutic/prophylactic food compositions |
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