CN103251884A - Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine for treating Alzheimer disease as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating Alzheimer disease as well as a preparation method and application thereof. The traditional Chinese medicine comprises the following components in parts by mass: 15 parts of codonopsis pilosula, 15 parts of astragalus mongholicus, 12 parts of rhizoma polygonati, 6 parts of polygonum multiflorum, 10 parts of curcuma aromatica, 8 parts of rhizoma acori graminei, 10 parts of ligusticum wallichii and 8 parts of earthworm. The method comprises the following steps of: adding the curcuma aromatica, the rhizoma acori graminei and the ligusticum wallichii into deionized water, heating for distilling and extracting volatile oil, dehydrating the volatile oil, clathrating with beta-cyclodextrin and drying at low temperature; collecting a distilled water solution with another vessel, adding the codonopsis pilosula, the astragalus mongholicus, the rhizoma polygonati, the polygonum multiflorum and earthworm into water, decorating, mixing decoctions, filtering to obtain filtrate, mixing the filtrate with the distilled water solution, concentrating to obtain concentrate, adding 95% ethanol to the concentrate to ensure that the alcohol precipitation concentration is 60%, fully stirring, standing for 24-48 hours, filtering to obtain filtrate, recovering ethanol from the filtrate, concentrate the filtrate subjected to ethanol removal to form thick paste and performing microwave drying on the thick paste to form a dry extract; and crushing the dry extract, adding a defined amount of dextrin or starch, performing wet granulation, drying and granulation, adding a volatile oil clathrate compound and uniformly mixing. By adopting methods of invigorating spleen and kidney, eliminating phlegm and dispersing blood stasis, the brain premature senility and brain aging are prevented and intervened, thereby delaying the development of the Alzheimer disease, improving the clinical symptoms and improving the life quality of patients.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of Alzheimer, relate in particular to a kind of Chinese medicine for the treatment of Alzheimer and its preparation method and application.
Background technology
(Alzheimer disease AD), is a kind of disease that is changed to feature with acquired intellectual deterioration and behavior personality to Alzheimer.Under the situation of unconscious obstacle, memory and cognitive function disorder are arranged, with speech, visual space technical ability, emotion or personality changes, and influence its social activity.The concealment of patient's onset, early symptom shows as nearly hypomnesis, personality changes, intelligence descends to some extent, and spatial orientation is bad, and often go astray from the group, fail to see homeward journey or initiative and reduce, labile affect, but daily life still can keep.Further develop then cognitive decrease, aphasia, agnosia occur, and focal neurological signs can occur, daily life can not be taken care of oneself, and shameless behavior, ethics behavior change are often arranged, even auditory hallucination, photis, vain hope, manic or depressive symptom occur.Late period then occurs comprehensive disturbance of intelligence, patient's bed, no autonomic movement, the nothing of keeping silent language or the fragmentation of giving ambiguous stayements be can't take care of oneself at all, and finally die from complication such as pulmonary infection, urinary system infection, pressure ulcer more.
Because the cause of disease and the pathogenesis of Alzheimer are still indeterminate, still do not have the effect method reverse so far and stop disease progression.The medicine for the treatment of Alzheimer such as cholinesterase inhibitor, antioxidant, anti-inflammatory drug, inhibition amyloid form medicine, estrogen, nerve growth factor etc. at present, all be to intervene at a certain pathological characteristic link of primary disease, still can not stop or delay the course of disease of Alzheimer, effect is all undesirable.
Summary of the invention
The purpose of this invention is to provide Chinese medicine of a kind of course of disease that can stop or delay Alzheimer, effective treatment Alzheimer and its preparation method and application.
The objective of the invention is to be achieved through the following technical solutions:
The Chinese medicine for the treatment of Alzheimer of the present invention comprises following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima.
The preparation method of Chinese medicine of above-mentioned treatment Alzheimer of the present invention comprises step:
At first, with Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three flavor medical materials, add 10～15 times of amount deionized waters, the heating distillating extracting oil dewaters the volatile oil that extracts with anhydrous sodium sulfite, use beta-cyclodextrin inclusion compound, cold drying again.Aqueous solution after distillation device is in addition collected, and is standby;
Then, with Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima five tastes medical material, decoct with water 2～3 times, collecting decoction filters, and the aqueous solution after filtrate and the distillation merges, concentrate, concentrated solution adds 95% ethanol, and making alcohol precipitation concentration is 60%, fully stir, left standstill 24～48 hours, and filtered filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, added an amount of dextrin or starch, wet granulation, drying, granulate add above-mentioned volatile oil clathrate compound, mixing.
The application of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention is used for the treatment of Alzheimer, and every day, dosage was 84 gram crude drug.
As seen from the above technical solution provided by the invention, Chinese medicine of the treatment Alzheimer that the invention process provides and its preparation method and application, adopt strengthening spleen, tonifying kidney, eliminating phlegm blood stasis dispelling method, can prevent and intervene cerebral senilism, brain aging, thereby delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality.
The specific embodiment
To be described in further detail the invention process below.
The Chinese medicine for the treatment of Alzheimer of the present invention, its preferable specific embodiment is:
Comprise following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima.
Each crude drug by proportion by weight is:
Radix Codonopsis 15 mass parts, the Radix Astragali 15 mass parts, Rhizoma Polygonati 12 mass parts, Radix Polygoni Multiflori 6 mass parts, Radix Curcumae 10 mass parts, Rhizoma Acori Graminei 8 mass parts, Rhizoma Chuanxiong 10 mass parts, Pheretima 8 mass parts.
The preparation method of Chinese medicine of above-mentioned treatment Alzheimer of the present invention, its preferable specific embodiment is:
Comprise step:
At first, with Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three flavor medical materials, add 10～15 times of amount deionized waters, the heating distillating extracting oil dewaters the volatile oil that extracts with anhydrous sodium sulfite, use beta-cyclodextrin inclusion compound, cold drying again.Aqueous solution after distillation device is in addition collected, and is standby;
Then, with Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima five tastes medical material, decoct with water 2～3 times, collecting decoction filters, and the aqueous solution after filtrate and the distillation merges, concentrate, concentrated solution adds 95% ethanol, and making alcohol precipitation concentration is 60%, fully stir, left standstill 24～48 hours, and filtered filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, added an amount of dextrin or starch, wet granulation, drying, granulate add above-mentioned volatile oil clathrate compound, mixing.
Finally make capsule.
The application of the Chinese medicine of above-mentioned treatment Alzheimer of the present invention, its preferable specific embodiment is:
Be used for the treatment of Alzheimer, every day, dosage was 84 gram crude drug.
Theoretical and long-term clinical experience development goes out according to classical Chinese medicine in the present invention, analyze by the etiology and pathogenesis to primary disease, think that deficiency of spleen and stomach is that Alzheimer is fallen ill originally, expectorant stasis of blood resistance is closed, clear key is covered, dysfunction of the mind is the key of its morbidity, and is clear and definite to Alzheimer deficiency of spleen and stomach, expectorant stasis of blood interlocking type curative effect.
The traditional Chinese medical science is thought, the kidney governing bones store essential substances is given birth to marrow and filled brain, " the brain being the house of mentality ", " sudden inspiration is remembered at brain not at the heart "; The spleen being the foundation of acquired constitution, source of generating QI and blood, body fluid is failed the pivot of cloth, ascending or descending movement of vital Qi, and brains and refreshing generation all derive from the essence of water and grain day after tomorrow.Generation and internal organs self hypofunction that expectorant is turbid is relevant, and it is dirty to concern spleen kidney two especially, and this shows more obviously in patients with Alzheimer disease.If old, positive QI-insufficiency, deficiency of spleen and stomach, insufficiency of the spleen then QI and blood lacks the source, deficiency of vital energy insufficiency of blood, " deficiency of vital energy deficiency pushes away blood, and then blood must have the stasis of blood ", blood stagnant in cerebral venation syndrome makes us forgetful.Expectorant is turbid form with blood stasis after, the normal friendship become trouble. reciprocal causation, more complicated pathological change appears then, cause the state of an illness to increase the weight of, touching difficulty heals.Deficiency of spleen and stomach, the expectorant stasis of blood are handed over resistance, hoodwink clearly that key is the basic pathogenesis of Alzheimer, also are the key points of clinical treatment.The present invention is according to theory of Chinese medical science and for many years to the understanding of Alzheimer pathogen and pathology of tcm, from traditional Chinese medical science organic conception, develop the present invention, adopt strengthening spleen, tonifying kidney, eliminating phlegm blood stasis dispelling method, can prevent and intervene cerebral senilism, brain aging, thereby delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality.
Medicine of the present invention is capsule formulation.
The zoopery example:
Adopt amyloid-beta rat intracerebroventricular injection and coupling transferinggrowthingfactor 1 intracerebral injection to produce existing rat behavior and learn change (learning memory disorder), the experimental Alzheimer's Disease Rats model that typical pathology (amyloid-beta deposition speckle) and neural biochemical feature are arranged again, carry out above-mentioned Chinese medicine accordingly to the pharmacodynamic study of this rat model learning and memory and cerebral cortex and the influence of hippocampal formation district cholinergic neurotransmitter, modeling success back (confirming by behavioristics's test and pathological observation), the beginning administration, two groups give rat aqueous solution of the present invention respectively and irritate stomach, normal group, model group all gives isometric normal saline and irritates stomach; And matched group is irritated stomach piracetam suspension, continuous 28 days.Answer water maze method and darkness avoidance test determination experiment Alzheimer disease model rat spatial discrimination ability of learning and memory (average latency) and passive avoidance response (bright chamber stop rate), its rat model cerebral cortex of measured by radioimmunoassay and hippocampal formation district acetyl choline content, choline acetylase and acetylcholine esterase active.The result: experimental Alzheimer disease model rat prolongs after with natural law; the lost average latency of water obviously increases; bright chamber stop rate significantly descends; rat model cerebral cortex and hippocampal formation district acetyl choline content reduce; choline acetylase is active to descend; acetylcholine esterase active raises, and compares with matched group, and difference has the significance meaning.The present invention can shorten the lost average latency of experimental model rat water; increase bright chamber stop rate; improve rat model cerebral cortex and hippocampal formation district acetyl choline content and choline acetylase activity; reduce acetylcholine esterase active; compare with model group or piracetam matched group, difference has the significance meaning.
Conclusion: the present invention can cholinergic neurotransmitter obviously improves experimental Alzheimer disease model learning and memory in rats ability in the brain by regulating.
Treat patients with Alzheimer disease by the present invention, can reach following effect:
One, good drug efficacy, evident in efficacy.Radix Codonopsis spleen reinforcing stomach reinforcing in the side, gas in the strong fortune, tonification is congenital; Rhizoma Polygonati can be mended vital essence, beneficial marrow to grow the day after tomorrow, and but it grows greasy property to get Radix Codonopsis, Rhizoma Acori Graminei, and helpless expectorant is given birth to wet anxiety, for controlling the key medicine of asthenia of both the spleen and kidney; Rhizoma Acori Graminei can " comfortable gas, the smooth mind, happy mood, beneficial will " (" fragrant celebrating hall random notes "), and can " happy hole, logical nine orifices, improve visual and auditory acuity, go out sound, always get the power of Xin Wenli key " (" herbal classic is fitted the source "), cover product first of the clear key for controlling expectorant; The Rhizoma Chuanxiong acrid in the mouth is " the gas medicine in the blood " (Compendium of Material Medica) promoting flow of QI and blood.Rhizoma Acori Graminei is joined Rhizoma Chuanxiong, an eliminating phlegm, and a blood stasis dispelling makes key open the stasis of blood expectorant that looses and disappears, and mind is recovered lost hearing, and Rhizoma Chuanxiong benefaction QI and blood, the light clear ease that goes up, the through sick institute of his medicine is led on the up high mountain peak of priming power, is encephalopathy guiding drug commonly used.All medicines share, and play the effect of tonifying speen and tonifying kidney, eliminating phlegm blood stasis dispelling, the brain-strengthening of having one's ideas straightened out altogether.The present invention has obtained certain effect to the research of Alzheimer, because it forms the globality of " monarch, minister, help, make " multilayer system of structure, effective ingredient acts on each link of primary disease respectively, not only can assist the human righteousness, regulate the whole body functional status, improve brain function, and can set upright the Eradicates heresy, treating both the principal and secondary aspects of a disease, and the low toxic and side effects because embodying show the present invention's special advantages aspect the treatment Alzheimer.
Two, Chinese medicine compatibility of the present invention is formed rationally, is applicable to Alzheimer deficiency of spleen and stomach, expectorant stasis of blood interlocking type patient, can prevent and intervene cerebral senilism, brain aging, thereby delay the development of Alzheimer, improve clinical symptoms, improve patients ' life quality, patient's compliance is good.
Specific embodiment:
The Chinese medicine for the treatment of Alzheimer, wherein raw material is formed by following weight proportion:
Radix Codonopsis (15g), the Radix Astragali (15g), Rhizoma Polygonati (12g), Radix Polygoni Multiflori (6g), Radix Curcumae (10g), Rhizoma Acori Graminei (8g), Rhizoma Chuanxiong (10g), Pheretima (8g), the daily dose of writing out a prescription: 84 grams.
Preparation process is:
(1) will write out a prescription in Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three flavor medical materials, adds 10～15 times of amount deionized waters, the heating distillating extracting oil dewaters the volatile oil of extraction with anhydrous sodium sulfite, use beta-cyclodextrin inclusion compound, cold drying again.Aqueous solution after distillation device is in addition collected; (2) will write out a prescription in Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima five tastes medical material, decoct with water collecting decoction 2～3 times, filter, the aqueous solution after filtrate and the distillation merges, and concentrates, concentrated solution adds 95% ethanol, making alcohol precipitation concentration is 60%, fully stirs, and leaves standstill 24～48 hours, filter, filtrate recycling ethanol is condensed into thick paste, and microwave drying becomes dry extract;
(3) dry extract is pulverized, added an amount of dextrin or starch, wet granulation, drying, granulate add above-mentioned volatile oil clathrate compound, and mixing incapsulates.
The present invention compares with the mode of prior art, has following at least a advantage:
1, good drug efficacy is improved learning and memory and cognitive function, and effect is clear and definite.
2, compare with Western medicine, multi-level, multipath is intervened the elderly brain functional disorder, improves the Alzheimer clinical symptoms, improves patients ' life quality, does not have tangible toxicity, can take for a long time.
3, easy to use, effective.
The above; only for the preferable specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, and anyly is familiar with those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (5)
1. a Chinese medicine for the treatment of Alzheimer is characterized in that, comprises following crude drug:
Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Pheretima.
2. Chinese medicine for the treatment of Alzheimer according to claim 1 and its preparation method and application is characterized in that, each crude drug by proportion by weight is:
Radix Codonopsis 15 mass parts, the Radix Astragali 15 mass parts, Rhizoma Polygonati 12 mass parts, Radix Polygoni Multiflori 6 mass parts, Radix Curcumae 10 mass parts, Rhizoma Acori Graminei 8 mass parts, Rhizoma Chuanxiong 10 mass parts, Pheretima 8 mass parts.
3. the preparation method of Chinese medicine of a claim 1 or 2 described treatment Alzheimer is characterized in that, comprises step:
At first, with Radix Curcumae, Rhizoma Acori Graminei, Rhizoma Chuanxiong three flavor medical materials, add 10～15 times of amount deionized waters, the heating distillating extracting oil dewaters the volatile oil that extracts with anhydrous sodium sulfite, use beta-cyclodextrin inclusion compound, cold drying again.Aqueous solution after distillation device is in addition collected, and is standby;
Then, with Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, Radix Polygoni Multiflori, Pheretima five tastes medical material, decoct with water 2～3 times, collecting decoction filters, and the aqueous solution after filtrate and the distillation merges, concentrate, concentrated solution adds 95% ethanol, and making alcohol precipitation concentration is 60%, fully stir, left standstill 24～48 hours, and filtered filtrate recycling ethanol, be condensed into thick paste, microwave drying becomes dry extract;
Afterwards, dry extract is pulverized, added an amount of dextrin or starch, wet granulation, drying, granulate add above-mentioned volatile oil clathrate compound, mixing.
4. the preparation method of Chinese medicine for the treatment of Alzheimer according to claim 3 is characterized in that, finally makes capsule.
5. the application of the Chinese medicine of a claim 1 or 2 described treatment Alzheimer is characterized in that, is used for the treatment of Alzheimer, and every day, dosage was 84 gram crude drug.
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| WO2016072392A1 (en) * | 2014-11-04 | 2016-05-12 | Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 | Agent for promoting tau protein production, and therapeutic or prophylactic drug and therapeutic or prophylactic food product composition for disease caused by tau protein deficiency |
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| US10576108B2 (en) | 2014-11-04 | 2020-03-03 | Well Stone Co. | Tau protein production accelerator, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by tau protein deficiency |
| AU2015344361B2 (en) * | 2014-11-04 | 2020-10-01 | Well Stone Co. | Tau protein production accelerator, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by tau protein deficiency |
| CN104547120A (en) * | 2014-12-18 | 2015-04-29 | 黑龙江儒泰生物制药有限责任公司 | Traditional Chinese medicine composition for treating alzheimer disease, as well as preparation method and application thereof |
| CN104587411A (en) * | 2015-02-11 | 2015-05-06 | 田胜硕 | Traditional Chinese medicine preparation for treating pick disease, and preparation method |
| CN109999155A (en) * | 2019-05-06 | 2019-07-12 | 孟胜喜 | The Chinese medicine composition and preparation method thereof for treating Alzheimer disease |
| CN109999155B (en) * | 2019-05-06 | 2021-07-30 | 孟胜喜 | Traditional Chinese medicine composition for treating Alzheimer disease and preparation method thereof |
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