CN103239680A - Traditional Chinese medicine for treating fatty liver syndrome in chicken - Google Patents
Traditional Chinese medicine for treating fatty liver syndrome in chicken Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating fatty liver syndrome in chicken. The traditional Chinese medicine comprises the medicinal raw materials, including semen cassia, zedoary, radix paeoniae alba, mangnolia officinalis, root of red-rooted salvia, irkutsk anemone rhizome, rhizoma alismatis, silybum marianum, indochina dragonplum fruit, dabeijie (Chinese character) potato, gambier, radix clematidis, kadsura pepper stem, ferula asafetida, semen raphani, selaginella tamariscina, astragalus mongholicus, Chinese yam, liquorice and lotus seed. The traditional Chinese medicine composition is good in curative effect, quick-acting, free of toxic and side effect, free of drug resistance, and low in cost.
Description
Technical field
The present invention relates to the herbal medicine technical field, relate in particular to a kind of syndromic Chinese medicine of chicken fatty liver that is used for the treatment of.
Background technology
Fatty liver syndrome (Fatty liver syndrome, FLS) see the report of American Couch in the beginning in 1956, this disease is a kind of because of feed nutrition material imbalance of chicken, causes the chicken internal metabolism in disorder and what cause is the disease of feature with liver generation steatosis.Fatty liver syndrome often betides the batterylaying of batterylaying, particularly egg-laying peak, is the broiler of overfertilization secondly.The commonly encountered diseases that at present should disease have become many national poultry husbandries.In recent years, the poultry husbandry of China has obtained the development of advancing by leaps and bounds, and the intensive culture scale constantly enlarges, and fatty liver syndrome happens occasionally in the laying hen field of China and professional raiser.All there is the report of this disease in provinces such as Zhejiang, Anhui, Henan, Hebei, and the trend that increases is year by year arranged.At present, this disease sickness rate is everlasting about 5 %, accounts for 8 %～10 % of whole dead chickens.This sick multiple laying hen that is born in the egg-laying peak lots of natural fleshing causes egg production descend gradually (2 %～50%).It brings serious economy loss for modern intensive aviculture, how effectively to prevent the syndromic generation of chicken fatty liver, has been subjected to the common concern of Chinese scholars.
The reason that fatty liver syndrome produces mainly contains: 1. inherited genetic factors: the ill property of there are differences of the chicken of different strains.Meat kind chicken fatty liver syndrome sickness rate is than egg kind chicken height.High laying rate may be one of factor of laying hen fatty liver syndrome generation; 2. feed nutrition: too much energy take the photograph the people be the laying hen fatty liver syndrome main diseases because of, make the energy in the chicken body be in positive balance, the deposition of fat and unnecessary carbohydrate change into fat by glyconeogenesis and accumulate at liver.Free choice feeding makes batterylaying easily produce fatty liver syndrome.Simultaneously when calcium and minority trace element also play very big facilitation to the generation of this disease to the albumen in the daily ration.Aspergillus flavus content also is the one of the main reasons that causes fatty liver syndrome in the daily ration; 3. feeding and management: any type ofly stress (trophism, managerial or pathologic) all may cause fatty liver syndrome.The chicken body is at high temperature low than energy requirement under the low temperature to energy requirement, and steatolysis is reduced, and causes the foie gras syndrome.The hen of raising in cages is more than the liver fat of floor husbandry hen.High stocking density also is the factor that causes fatty liver syndrome.The release of endogenous estrogen also is the hereditary inducement that produces fatty liver syndrome during sexual maturity.
The traditional Chinese herbal medicine of China is in the metabolism of regulation and control fowl fat, and control fowl fatty liver aspect has advantageous advantage, can be used for control fowl fatty liver syndrome.
Summary of the invention
Technical problem to be solved by this invention provides a kind of syndromic Chinese medicine composition of chicken fatty liver that is used for the treatment of, and it has good effect, instant effect, have no side effect, have no drug resistance, advantage with low cost.
For solving the problems of the technologies described above, the invention provides a kind of syndromic Chinese medicine composition of chicken fatty liver that is used for the treatment of, its crude drug comprises Semen Cassiae, Rhizoma Wenyujin Concisum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Rhizoma Anemones Altaicae, Rhizoma Alismatis, Herba Silybi mariani, Fructus Dracontomeli Duperreani, DABAIJIE potato, GAMBIER, Radix Clematidis, Caulis Piperis Kadsurae, Resina Ferulae, Semen Raphani, Herba Selaginellae, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae and Semen Nelumbinis.
Wherein, the weight of each crude drug is respectively Semen Cassiae 220g ~ 240g in the described Chinese medicine composition, Rhizoma Wenyujin Concisum 270g ~ 290g, Radix Paeoniae Alba 450g ~ 470g, Cortex Magnoliae Officinalis 180g ~ 200g, Radix Salviae Miltiorrhizae 350g ~ 370g, Rhizoma Anemones Altaicae 410g ~ 430g, Rhizoma Alismatis 260g ~ 280g, Herba Silybi mariani 160g ~ 180g, Fructus Dracontomeli Duperreani 210g ~ 230g, DABAIJIE potato 310g ~ 330g, GAMBIER 300g ~ 320g, Radix Clematidis 390g ~ 410g, Caulis Piperis Kadsurae 200g ~ 220g, Resina Ferulae 270g ~ 290g, Semen Raphani 330g ~ 350g, Herba Selaginellae 260g ~ 280g, Radix Astragali 490g ~ 510g, Rhizoma Dioscoreae 220g ~ 240g, Radix Glycyrrhizae 180g ~ 200g and Semen Nelumbinis 220g ~ 240g.
Wherein, the weight portion of each crude drug is respectively Semen Cassiae 230g, Rhizoma Wenyujin Concisum 280g, Radix Paeoniae Alba 460g, Cortex Magnoliae Officinalis 190g, Radix Salviae Miltiorrhizae 360g, Rhizoma Anemones Altaicae 420g, Rhizoma Alismatis 270g, Herba Silybi mariani 170g, Fructus Dracontomeli Duperreani 220g, DABAIJIE potato 320g, GAMBIER 310g, Radix Clematidis 400g, Caulis Piperis Kadsurae 210g, Resina Ferulae 280g, Semen Raphani 340g, Herba Selaginellae 270g, Radix Astragali 500g, Rhizoma Dioscoreae 230g, Radix Glycyrrhizae 190g and Semen Nelumbinis 230g in the described Chinese medicine composition.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is decoction liquor, is specially:
Raw material components is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as fronts again, decocted 1 ~ 2 hour, decoction liquor is filtered, and filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor of 2g ~ 3g crude drug amount.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step, the Radix Paeoniae Alba, Rhizoma Anemones Altaicae, Fructus Dracontomeli Duperreani, DABAIJIE potato, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae and Semen Nelumbinis are mixed by above-mentioned weight proportion, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, makes first powder; Temperature at oven drying is 105 ℃, drying time 15～25min;
Second step, remaining crude drug component is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as front again, decocts 1 ~ 2 hour, and decoction liquor is filtered, filtrate is mixed, concentrate, except anhydrating drying, pulverize, obtain second powder;
In the 3rd step, with first powder and second powder mixes, obtain the Chinese medicine composition composition powders.
The present invention also provides a kind of syndromic feedstuff of chicken fatty liver that is used for the treatment of, and it comprises major ingredient and is used for the treatment of the syndromic Chinese medicine composition additive of chicken fatty liver.
Wherein with respect to the major ingredient of 100 weight portions, the addition of described Chinese medicine composition additive is 15 weight portions ~ 20 weight portions.
The crude drug of described Chinese medicine composition additive comprises Semen Cassiae, Rhizoma Wenyujin Concisum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Rhizoma Anemones Altaicae, Rhizoma Alismatis, Herba Silybi mariani, Fructus Dracontomeli Duperreani, DABAIJIE potato, GAMBIER, Radix Clematidis, Caulis Piperis Kadsurae, Resina Ferulae, Semen Raphani, Herba Selaginellae, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae and Semen Nelumbinis.
Wherein, the weight of each crude drug is respectively Semen Cassiae 220g ~ 240g in the described Chinese medicine composition additive, Rhizoma Wenyujin Concisum 270g ~ 290g, Radix Paeoniae Alba 450g ~ 470g, Cortex Magnoliae Officinalis 180g ~ 200g, Radix Salviae Miltiorrhizae 350g ~ 370g, Rhizoma Anemones Altaicae 410g ~ 430g, Rhizoma Alismatis 260g ~ 280g, Herba Silybi mariani 160g ~ 180g, Fructus Dracontomeli Duperreani 210g ~ 230g, DABAIJIE potato 310g ~ 330g, GAMBIER 300g ~ 320g, Radix Clematidis 390g ~ 410g, Caulis Piperis Kadsurae 200g ~ 220g, Resina Ferulae 270g ~ 290g, Semen Raphani 330g ~ 350g, Herba Selaginellae 260g ~ 280g, Radix Astragali 490g ~ 510g, Rhizoma Dioscoreae 220g ~ 240g, Radix Glycyrrhizae 180g ~ 200g and Semen Nelumbinis 220g ~ 240g.
The present invention also provides the preparation method of above-mentioned feedstuff, and it is specially:
The first step, the preparation of Chinese medicine composition additive, the Radix Paeoniae Alba, Rhizoma Anemones Altaicae, Fructus Dracontomeli Duperreani, DABAIJIE potato, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae and Semen Nelumbinis are mixed by above-mentioned weight proportion, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, and liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, makes first powder; Temperature at oven drying is 105 ℃, and drying time, 15～25min mixed remaining crude drug component by weight ratio, send into and be ground into fine powder in the pulverizer, add the water with respect to 3 ~ 5 times of fine powder quality, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds the water with quality such as front again, decocts 1 ~ 2 hour, decoction liquor is filtered, and filtrate is mixed, and concentrates, except anhydrating, drying is pulverized, obtain second powder, with first powder and second powder mixes, obtain the Chinese medicine composition additive;
Second step; ratio is got major ingredient and described Chinese medicine composition additive combination to together by weight; putting into multiplex mixer stirred 150 minutes; put into the ring mode pulverizer after the taking-up and be ground into powder; take out then and put into dehydrator; the aridity of control dried material is 77% ~ 85%; the time of smoking is 50 ~ 70 minutes; putting into multiplex mixer after removal and cooling stirred 200 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is between 70 ℃-80 ℃; the expanded time is 1 ~ 2 hour, and the aridity of control material to be extruded is 80% ~ 90%, changes over to after the taking-up and produces precipitation hard particles feedstuff in the ring mode grit machine; sieve with 80 meshes then, can pack by required weight.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention has good effect aspect the treatment chicken fatty liver syndrome, instant effect, have no side effect, have no drug resistance, advantage with low cost.
The specific embodiment
From traditional Chinese medical science angle, the formation of fatty liver is because liver is lost thin clear, dysfunction of the spleen in transportation, retention of damp-heat in the interior, the turbid pent-up of expectorant, congestion blocks and finally causes the resistance of the damp-phlegm stasis of blood to be tied mutually, numbness resistance liver venation, body can not be transported to whole body everywhere with the little normal distribution of foodstuff essence, thereby fat takes place, the liquid phlegm-damp holds in skin, among the internal organs, cause a series of clinical symptoms and the sign of fatty liver, therefore, for the treatment of fatty liver syndrome mainly with dispelling phlegm and eliminating dampness, blood circulation promoting and blood stasis dispelling, dispersing the stagnated live-QI to relieve the stagnation of QI, the spleen invigorating food stagnation removing is main, is aided with heat-clearing and toxic substances removing simultaneously, the kidney invigorating nourishing the liver, function of gallbladder promoting eliminate indigestion are the Therapeutic Principle.
The crude drug of described Chinese medicine composition comprises Semen Cassiae, Rhizoma Wenyujin Concisum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Rhizoma Anemones Altaicae, Rhizoma Alismatis, Herba Silybi mariani, Fructus Dracontomeli Duperreani, DABAIJIE potato, GAMBIER, Radix Clematidis, Caulis Piperis Kadsurae, Resina Ferulae, Semen Raphani, Herba Selaginellae, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae and Semen Nelumbinis.
Further, described Chinese medicine composition only is made of the above-mentioned raw materials medicine.
The weight of each crude drug is respectively Semen Cassiae 220g ~ 240g in the described Chinese medicine composition, Rhizoma Wenyujin Concisum 270g ~ 290g, Radix Paeoniae Alba 450g ~ 470g, Cortex Magnoliae Officinalis 180g ~ 200g, Radix Salviae Miltiorrhizae 350g ~ 370g, Rhizoma Anemones Altaicae 410g ~ 430g, Rhizoma Alismatis 260g ~ 280g, Herba Silybi mariani 160g ~ 180g, Fructus Dracontomeli Duperreani 210g ~ 230g, DABAIJIE potato 310g ~ 330g, GAMBIER 300g ~ 320g, Radix Clematidis 390g ~ 410g, Caulis Piperis Kadsurae 200g ~ 220g, Resina Ferulae 270g ~ 290g, Semen Raphani 330g ~ 350g, Herba Selaginellae 260g ~ 280g, Radix Astragali 490g ~ 510g, Rhizoma Dioscoreae 220g ~ 240g, Radix Glycyrrhizae 180g ~ 200g and Semen Nelumbinis 220g ~ 240g.
Further preferred, the weight portion of each crude drug is respectively Semen Cassiae 230g, Rhizoma Wenyujin Concisum 280g, Radix Paeoniae Alba 460g, Cortex Magnoliae Officinalis 190g, Radix Salviae Miltiorrhizae 360g, Rhizoma Anemones Altaicae 420g, Rhizoma Alismatis 270g, Herba Silybi mariani 170g, Fructus Dracontomeli Duperreani 220g, DABAIJIE potato 320g, GAMBIER 310g, Radix Clematidis 400g, Caulis Piperis Kadsurae 210g, Resina Ferulae 280g, Semen Raphani 340g, Herba Selaginellae 270g, Radix Astragali 500g, Rhizoma Dioscoreae 230g, Radix Glycyrrhizae 190g and Semen Nelumbinis 230g in the described Chinese medicine composition.
Above-mentioned Chinese medicine composition provided by the present invention can be prepared into decoction liquor, gavages in ill chicken, also can be prepared into powder, mixes in feedstuff the ill chicken of feeding.
The present invention also provides the decoction liquor of above-mentioned Chinese medicine composition, and its preparation method is specially:
Raw material components is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as fronts again, decocted 1 ~ 2 hour, decoction liquor is filtered, and filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor of 2g ~ 3g crude drug amount.
The present invention also provides above-mentioned Chinese medicine composition composition powders, and its preparation method is specially:
The first step, the Radix Paeoniae Alba, Rhizoma Anemones Altaicae, Fructus Dracontomeli Duperreani, DABAIJIE potato, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae and Semen Nelumbinis are mixed by above-mentioned weight proportion, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, makes first powder; Temperature at oven drying is 105 ℃, drying time 15～25min;
Second step, remaining crude drug component is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as front again, decocts 1 ~ 2 hour, and decoction liquor is filtered, filtrate is mixed, concentrate, except anhydrating drying, pulverize, obtain second powder;
In the 3rd step, with first powder and second powder mixes, obtain the Chinese medicine composition composition powders.
The present invention also provides a kind of feedstuff, and its raw material comprises major ingredient and above-mentioned Chinese medicine composition composition powders, and with respect to the major ingredient of 100 weight portions, the addition of described Chinese medicine composition composition powders is 15 weight portions ~ 20 weight portions, more preferably 18 weight portions.
Described major ingredient specifically comprises bean cake 180 ~ 350kg, Zein powder 120 ~ 200kg, Semen Maydis powder 420 ~ 580kg, stone powder 4 ~ 7kg, calcium hydrogen phosphate 6 ~ 10kg.
Further preferred, major ingredient specifically comprises bean cake 250kg, Zein powder 160kg, Semen Maydis powder 490kg, stone powder 6kg, calcium hydrogen phosphate 8kg.
The present invention also provides the preparation method of above-mentioned feedstuff, and it is specially:
The ratio Chinese medicine composition composition powders of getting major ingredient and preparation is grouped together by weight; putting into multiplex mixer stirred 150 minutes; put into the ring mode pulverizer after the taking-up and be ground into powder; take out then and put into dehydrator; the aridity of control dried material is 77% ~ 85%; the time of smoking is 50 ~ 70 minutes; putting into multiplex mixer after removal and cooling stirred 200 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is between 70 ℃-80 ℃; the expanded time is 1 ~ 2 hour; the aridity of control material to be extruded is 80% ~ 90%; change over to after the taking-up and produce precipitation hard particles feedstuff in the ring mode grit machine, sieve with 80 meshes then, can pack by required weight.
Described feedstuff can also add conventional additives such as flavoring agent, vitamin(e) supplement, amino acid additive, trace mineral supplement.
Each crude drug pharmacology is as follows:
Semen Cassiae: bitter in the mouth, cold nature is gone into large intestine, kidney, Liver Channel, has purging liver-fire, and the effect of loosening bowel to relieve constipation is used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, cards such as constipation." Bencao Jingshu ": Semen Cassiae, its salty in the mouth is flat, and " not record " is beneficial nontoxic with sweet being slightly cold of hardship.Salty aqueous vapor, rusticly sweet, hardship can expel the heat-evil, the flat gastric qi of closing, cold can expelling the heat-evil by tonifying YIN, just medicine is being also for liver meridian man.Also go into the gallbladder kidney.Liver opening at eye, the refreshing light of gb 1 belongs to kidney, so main optic atrohic blindness order is excessive, the red tunica albuginea of skin, swelling ophthalmalgia lacrimation." not Lu " holds concurrently and treats blue-purple lips." herbal classic " obeys beneficial with nothing left person for a long time, tonifying YIN expels the heat-evil, due to the gas of big invigorating the liver and kidney also.
Rhizoma Wenyujin Concisum: latin name
Rhizoma Wenyujin Concisum, acrid in the mouth, hardship, warm in nature, return liver, spleen channel, have the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia.Be used for amenorrhea due to stagnation of blood, menalgia, the breast side of body twinges, rheumatic arthralgia, shoulder arm pain, cards such as injury from falling down.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature is gone into liver, spleen channel, the joint venture of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG is mainly used in headache feeling of fullness in the head, vertigo and tinnitus, the irritated irritability of deficiecny of liver-YIN, excessive rising of liver-YANG; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of the wet resistance of deficiency of the liver stasis; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery stomachache; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as carpopedal spasm pain of supporting, and has antithrombotic to form and hepatoprotective effect, and dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus are had inhibitory action.
Cortex Magnoliae Officinalis: bitter in the mouth, suffering, warm in nature, return spleen channel; The stomach warp; Large intestine channel has the circulation of qi promoting removing food stagnancy; Dampness is except full; The effect of lowering the adverse QI to relieve asthma cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, the gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest card such as breath with cough.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, go into the heart, Liver Channel, the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming is arranged, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, the dysmenorrhoea amenorrhea; Stagnation of QI-blood, symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as fat around interior fat and the testis, alleviates insulin secretion and glycometabolic early stage infringement.
Rhizoma Anemones Altaicae: latin name
Irkutsk Anemone Rhizome, acrid in the mouth, warm in nature, GUIXIN; Liver; Spleen channel has waking up the patient from unconsciousness by dissipating phlegm; Calm the nerves; A surname is wet to be amusing; The effect of detoxifcation.Main calentura coma; Epilepsy; Deafness with qi stagnation; Dreaminess is forgetful; Abdominal distention uncomfortable in chest; Inappetence; Rheumatic arthralgia; Carbuncle; Cards such as scabies.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, go into kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria are arranged, the lung that clears away heart-fire, rush down the effect of kidney fire, be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The heresy of diseases caused by retention of fluid phlegm-damp is stranded resistance, causes dizzy that the clear YANG failing to ascend voiced sound does not fall; The dysuria of damp invasion of lower energizer, the puckery pain of red weak point, and card such as jaundice due to damp-heat.
Herba Silybi mariani: cool in nature, bitter in the mouth is returned liver, gallbladder meridian, has heat-clearing and toxic substances removing, and the effect of depressed liver-energy dispersing and function of gallbladder promoting is used for dampness-heat in the liver and gallbladder, hypochondriac pain, cards such as jaundice.
Fructus Dracontomeli Duperreani: latin name
Dracontomelon duperreanum Pierre, sweet in the mouth, acid, cool in nature, have stomach invigorating; Promote the production of body fluid; Sober up; The effect of detoxifcation.Cure mainly inappetence; Calentura is thirsty; Drunk; Laryngopharynx swelling and pain; Pathogenic wind-toxic sore card such as itch.
DABAIJIE potato: latin name
AristolochiakwangsiensisChunetHow, bitter in the mouth, cold in nature, GUIXIN, stomach, large intestine channel has regulating QI to relieve pain; Heat-clearing and toxic substances removing; The effect of hemostasis.Main spastic stomachache; Stomachache; Acute gastroenteritis; Gastric and duodenal ulcers; Dysentery; Traumatic injury; Sore and toxic; Traumatic hemorrhage; Venom; Cards such as bone tuberculosis.
GAMBIER: latin name
Extractum Uncariae Gambieris, bitter in the mouth; Puckery; Cool in nature, have removing dampness and hold back skin ulcer; The hemostasis analgesic therapy; The effect of removing heat-phlegm, treatment of ulcer are burst for a long time and are not held back; Eczema flowing water; Ulcerative gingivitis; Aphtha; Spitting of blood; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Traumatic hemorrhage; The hemorrhoid carbuncle; Cards such as phlegm-heat cough.
Radix Clematidis: acrid in the mouth, salty, warm in nature, go into urinary bladder channel, has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the effect of the hypochondriac lump of loosing cures mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, cards such as all a fishbone or other bone caught in the throat pharynxs.
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature is returned Liver Channel, has wind-damp dispelling, the meridian dredging, the effect of stopping numbness pain cures mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, cards such as joint stuffiness.
Resina Ferulae: bitter in the mouth, suffering, warm in nature, return kidney, stomach warp, have removing food stagnancy, the painful abdominal mass of loosing, the effect of parasite killing is used for meat stagnation, blood stasis lump in the abdomen, mass in abdomen, cards such as abdominal pain due to worm stagnation.
Semen Raphani: property is flat, and acrid in the mouth, sweet is returned lung, spleen, stomach warp, having to help digestion except expanding, and the effect of lowering the adverse-rising QI to resolve phlegm cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant and stops up card such as breath with cough.
Herba Selaginellae: acrid in the mouth, property is flat, returns liver, heart channel, has the effect of promoting blood circulation to restore menstrual flow.Be used for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down is spitted blood, and metrorrhagia is had blood in stool, cards such as proctoptosis.
The Radix Astragali: sweet in the mouth, warm in nature, go into spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, cards such as insufficiency of vital energy and blood.
Rhizoma Dioscoreae: sweet in the mouth, property are put down, and go into lung, spleen, stomach warp, and the spleen reinforcing nourishing the stomach is arranged, and lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting cures mainly weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, cards such as the vexed diarrhoea of gastral cavity.
Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Semen Nelumbinis: sweet in the mouth, puckery, property is flat, returns spleen, kidney, heart channel, has the effect of spleen reinforcing antidiarrheal, supplementing the kidney to control the nocturnal, tranquilizing by nourishing the heart, is used for weakness of the spleen and stomach, and lack of appetite is weak, and vomiting is had loose bowels, and it is not solid to suffer from a deficiency of the kidney, emission and spermatorrhea, nocturnal emission turbid urine, malaise, cardiac muscle, cards such as insomnia.
Chinese medicine composition provided by the invention is by improving the blood circulation of whole body and local organization, portal venous flow increased, and then improved blood and the nutrition supply of liver, the hepatocyte metabolism is restored and strengthens.The improvement of liver blood flow will be accelerated the outward transport of liver fat.And the recovery of hepatocyte metabolism and reinforcement also will be accelerated the oxidation of fat in hepatocyte.Thereby alleviate the steatosis degree of liver.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1 decocting for Chinese herbal medicine liquid 1
With Semen Cassiae 230g, Rhizoma Wenyujin Concisum 280g, Radix Paeoniae Alba 460g, Cortex Magnoliae Officinalis 190g, Radix Salviae Miltiorrhizae 360g, Rhizoma Anemones Altaicae 420g, Rhizoma Alismatis 270g, Herba Silybi mariani 170g, Fructus Dracontomeli Duperreani 220g, DABAIJIE potato 320g, GAMBIER 310g, Radix Clematidis 400g, Caulis Piperis Kadsurae 210g, Resina Ferulae 280g, Semen Raphani 340g, Herba Selaginellae 270g, Radix Astragali 500g, Rhizoma Dioscoreae 230g, Radix Glycyrrhizae 190g and Semen Nelumbinis 230g mix, send into and be ground into fine powder in the pulverizer, the water that adds 23.5kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 23.5kg again, decocted 2 hours, decoction liquor is filtered, filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor 1 of 2g crude drug amount.
Embodiment 2 decocting for Chinese herbal medicine liquid 2
With Semen Cassiae 220g, Rhizoma Wenyujin Concisum 270g, Radix Paeoniae Alba 450g, Cortex Magnoliae Officinalis 180g, Radix Salviae Miltiorrhizae 350g, Rhizoma Anemones Altaicae 410g, Rhizoma Alismatis 260g, Herba Silybi mariani 160g, Fructus Dracontomeli Duperreani 210g, DABAIJIE potato 310g, GAMBIER 300g, Radix Clematidis 390g, Caulis Piperis Kadsurae 200g, Resina Ferulae 270g, Semen Raphani 330g, Herba Selaginellae 260g, Radix Astragali 490g, Rhizoma Dioscoreae 220g, Radix Glycyrrhizae 180g and Semen Nelumbinis 220g mix, send into and be ground into fine powder in the pulverizer, the water that adds 23kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 23kg again, decocted 2 hours, decoction liquor is filtered, filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor 2 of 3g crude drug amount.
Embodiment 3 decocting for Chinese herbal medicine liquid 3
With Semen Cassiae 240g, Rhizoma Wenyujin Concisum 290g, Radix Paeoniae Alba 470g, Cortex Magnoliae Officinalis 200g, Radix Salviae Miltiorrhizae 370g, Rhizoma Anemones Altaicae 430g, Rhizoma Alismatis 280g, Herba Silybi mariani 180g, Fructus Dracontomeli Duperreani 230g, DABAIJIE potato 330g, GAMBIER 320g, Radix Clematidis 410g, Caulis Piperis Kadsurae 220g, Resina Ferulae 290g, Semen Raphani 350g, Herba Selaginellae 280g, Radix Astragali 510g, Rhizoma Dioscoreae 240g, Radix Glycyrrhizae 200g and Semen Nelumbinis 240g mix, send into and be ground into fine powder in the pulverizer, the water that adds 25kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 25kg again, decocted 2 hours, decoction liquor is filtered, filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor 3 of 2g crude drug amount.
Embodiment 4 Chinese medicine composition composition powders
Radix Paeoniae Alba 460g, Rhizoma Anemones Altaicae 420g, Fructus Dracontomeli Duperreani 220g, DABAIJIE potato 320g, Caulis Piperis Kadsurae 210g, Radix Astragali 500g, Rhizoma Dioscoreae 230g and Semen Nelumbinis 230g are mixed, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 25 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, and liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, temperature at oven drying is 105 ℃, drying time 20min, make first powder, with Semen Cassiae 230g, Rhizoma Wenyujin Concisum 280g, Cortex Magnoliae Officinalis 190g, Radix Salviae Miltiorrhizae 360g, Rhizoma Alismatis 270g, Herba Silybi mariani 170g, GAMBIER 310g, Radix Clematidis 400g, Resina Ferulae 280g, Semen Raphani 340g, Herba Selaginellae 270g, Radix Glycyrrhizae 190g mixes, and sends into and is ground into fine powder in the pulverizer, the water that adds 15kg, decocted 4 hours, decoction liquor is filtered, and filtering residue adds the water of 15kg again, decocted 2 hours, decoction liquor is filtered, and filtrate is mixed, and concentrates, except anhydrating, drying is pulverized, and obtains second powder, with first powder and second powder mixes, obtain the Chinese medicine composition composition powders.
Embodiment 5 feedstuffs
With bean cake 250kg; Zein powder 160kg; Semen Maydis powder 490kg; stone powder 6kg; the Chinese medicine composition composition powders of calcium hydrogen phosphate 8kg and 18kg embodiment 4 preparations is grouped together; putting into multiplex mixer stirred 150 minutes; put into the ring mode pulverizer after the taking-up and be ground into powder; take out then and put into dehydrator, the aridity of control dried material is 85%, and the time of smoking is 70 minutes; putting into multiplex mixer after removal and cooling stirred 200 minutes; it is expanded to put into the ring mode bulking machine after the taking-up, and the temperature of control bulking machine is between 80 ℃, and the expanded time is 2 hours; the aridity of control material to be extruded is 90%; change over to after the taking-up and produce precipitation hard particles feedstuff in the ring mode grit machine, sieve with 80 meshes then, can pack by required weight.
Embodiment 6 pharmacodynamic studies
Trial drug: the decoction liquor of the embodiment of the invention 1 preparation
Normal feedstuff constituent is: Semen Maydis powder 58%, bean cake 13. 5%, Testa Tritici 4%, calcium hydrogen phosphate 1. 2%, oily beans 1.5%, cottonseed meal 3.5%, rapeseed cake 3.5%, shellfish powder 7.5%, peanut cake 4.85%, premix material 0.5%, stone powder 0. 15%, Fructus Hordei Germinatus 1. 5%, Sal 0. 3% (available from reaching industrial corporation in the Baoding).
Consisting of of high lipid food: normal feedstuff 82. 5%, cholesterol 2%, Adeps Sus domestica 10%, sucrose 5%, propylthiouracil 0. 5%.
Experimental animal grouping and processing
Choose 600 of the broiler of 30 ages in days, be divided into normal healthy controls group, pathological model group and treatment by Chinese herbs group at random, 200 every group, after the week that conforms, carry out the test in two weeks by a definite date.The normal healthy controls group normal feedstuff of feeding, pathological model group and the treatment by Chinese herbs group high lipid food of feeding, the treatment by Chinese herbs group is irritated the decoction liquor 1 of the stomach embodiment of the invention 1 preparation in the feeding high lipid food.
Sample collecting
In preceding 1 day of on-test and off-test each take a blood sample once (12h fasting before the blood sampling), preparation serum.After taking a blood sample for the second time, every chicken body weight of weighing, the complete liver of cutting of cutting open the belly takes by weighing liver and weighs, and it is fixing that a little hepatic tissue of clip is put into Bouin liquid.And will remain liver and shred, place 105 ℃ of baking ovens to dry.
Sample determination
The mensuration of serum biochemistry index
Serum TG, TC, GPT, GOT all measure at 723 type visible spectrophotometers (Shanghai the 3rd analytical tool factory), and test kit is available from the safe clinical reagent company limited of Beijing northization.
The mensuration of hepatic fat content
Liver pulverize with oven dry, accurately take by weighing 3 g, wrap (filter paper is accurately weighed through electronic balance in advance) with dry filter paper, put into apparatus,Soxhlet's absolute ether extracting 12h (bath temperature is 70～80 ℃), with filter paper packet oven dry after the defat, accurately take by weighing weight.Hepatic fat content (%)=(filter paper packet weight after the preceding filter paper packet weight-extracting of extracting) (filter paper packet weight before the extracting-filter paper weight) * 100%.
The statistical disposition of test data
Test data adopts the variance analysis as a result of single factor randomized block experiment with Excel 2003 and SPSS (11.0) data processing software.Analyze the significance of difference between each group, the result represents with average ± standard error.And mean carried out significance test.
The result
Chinese medicine of the present invention the results are shown in Table 1 to the influence of serum TG, TC.
The influence of table 1 serum TG, TC
Off-test, pathological model group serum T G, the TC content utmost point are higher than normal healthy controls group (P＜0.01) significantly, illustrate that pathological model copies success, treatment by Chinese herbs group serum T G, the TC content utmost point are markedly inferior to the pathological model group, compare with the normal healthy controls group, that raise and few, as seen, Chinese medicine of the present invention raises to the caused blood fat of high lipid food and has certain regulating action.
Chinese medicine of the present invention the results are shown in Table 2 to the influence of serum GPT, GOT.
The influence of table 2 serum GPT, GOT
Off-test, pathological model group serum GPT, GOT value be apparently higher than normal healthy controls group (P＜0.01), and it is not remarkable that treatment by Chinese herbs group serum GPT, GOT value and normal healthy controls group are compared difference, compares with the pathological model group, significantly reduces.
The influence of hepatic fat content and liver weight/body weight the results are shown in Table 3.
Table 3 hepatic fat content and liver weight/body weight influence %
Off-test, pathological model group hepatic fat content, liver weight/body weight value are apparently higher than normal healthy controls group (P＜0.01), it is not remarkable that treatment by Chinese herbs group hepatic fat content, liver weight/body weight and normal healthy controls group are compared difference, compares with the pathological model group, significantly reduces.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (10)
1. one kind is used for the treatment of the syndromic Chinese medicine composition of chicken fatty liver, it is characterized in that: the crude drug of described Chinese medicine composition comprises Semen Cassiae, Rhizoma Wenyujin Concisum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Rhizoma Anemones Altaicae, Rhizoma Alismatis, Herba Silybi mariani, Fructus Dracontomeli Duperreani, DABAIJIE potato, GAMBIER, Radix Clematidis, Caulis Piperis Kadsurae, Resina Ferulae, Semen Raphani, Herba Selaginellae, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae and Semen Nelumbinis.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Semen Cassiae 220g ~ 240g in the described Chinese medicine composition, Rhizoma Wenyujin Concisum 270g ~ 290g, Radix Paeoniae Alba 450g ~ 470g, Cortex Magnoliae Officinalis 180g ~ 200g, Radix Salviae Miltiorrhizae 350g ~ 370g, Rhizoma Anemones Altaicae 410g ~ 430g, Rhizoma Alismatis 260g ~ 280g, Herba Silybi mariani 160g ~ 180g, Fructus Dracontomeli Duperreani 210g ~ 230g, DABAIJIE potato 310g ~ 330g, GAMBIER 300g ~ 320g, Radix Clematidis 390g ~ 410g, Caulis Piperis Kadsurae 200g ~ 220g, Resina Ferulae 270g ~ 290g, Semen Raphani 330g ~ 350g, Herba Selaginellae 260g ~ 280g, Radix Astragali 490g ~ 510g, Rhizoma Dioscoreae 220g ~ 240g, Radix Glycyrrhizae 180g ~ 200g and Semen Nelumbinis 220g ~ 240g.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Semen Cassiae 230g, Rhizoma Wenyujin Concisum 280g, Radix Paeoniae Alba 460g, Cortex Magnoliae Officinalis 190g, Radix Salviae Miltiorrhizae 360g, Rhizoma Anemones Altaicae 420g, Rhizoma Alismatis 270g, Herba Silybi mariani 170g, Fructus Dracontomeli Duperreani 220g, DABAIJIE potato 320g, GAMBIER 310g, Radix Clematidis 400g, Caulis Piperis Kadsurae 210g, Resina Ferulae 280g, Semen Raphani 340g, Herba Selaginellae 270g, Radix Astragali 500g, Rhizoma Dioscoreae 230g, Radix Glycyrrhizae 190g and Semen Nelumbinis 230g in the described Chinese medicine composition.
4. the preparation method of the described Chinese medicine composition of claim 1 to 3 is characterized in that: when the dosage form of described Chinese medicine composition is decoction liquor, is specially,
Raw material components is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as fronts again, decocted 1 ~ 2 hour, decoction liquor is filtered, and filtrate is mixed, concentrate except anhydrating, obtain to contain in every ml solution the decoction liquor of 2g ~ 3g crude drug amount.
5. the preparation method of the described Chinese medicine composition of claim 1 to 3 is characterized in that: when the dosage form of described Chinese medicine composition is powder, is specially,
The first step, the Radix Paeoniae Alba, Rhizoma Anemones Altaicae, Fructus Dracontomeli Duperreani, DABAIJIE potato, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae and Semen Nelumbinis are mixed by above-mentioned weight proportion, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, makes first powder; Temperature at oven drying is 105 ℃, drying time 15～25min;
Second step, remaining crude drug component is mixed by weight ratio, send into and be ground into fine powder in the pulverizer, adding decocted 2 ~ 4 hours with respect to the water of 3 ~ 5 times of fine powder quality, and decoction liquor is filtered, filtering residue adds the water with quality such as front again, decocts 1 ~ 2 hour, and decoction liquor is filtered, filtrate is mixed, concentrate, except anhydrating drying, pulverize, obtain second powder;
In the 3rd step, with first powder and second powder mixes, obtain the Chinese medicine composition composition powders.
6. one kind is used for the treatment of the syndromic feedstuff of chicken fatty liver, it is characterized in that: comprise major ingredient and be used for the treatment of the syndromic Chinese medicine composition additive of chicken fatty liver.
7. feedstuff as claimed in claim 6, it is characterized in that: with respect to the major ingredient of 100 weight portions, the addition of described Chinese medicine composition additive is 15 weight portions ~ 20 weight portions.
8. as claim 6 or 7 described feedstuffs, it is characterized in that: the crude drug of described Chinese medicine composition additive comprises Semen Cassiae, Rhizoma Wenyujin Concisum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Radix Salviae Miltiorrhizae, Rhizoma Anemones Altaicae, Rhizoma Alismatis, Herba Silybi mariani, Fructus Dracontomeli Duperreani, DABAIJIE potato, GAMBIER, Radix Clematidis, Caulis Piperis Kadsurae, Resina Ferulae, Semen Raphani, Herba Selaginellae, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae and Semen Nelumbinis.
9. feedstuff as claimed in claim 8, it is characterized in that: the weight of each crude drug is respectively Semen Cassiae 220g ~ 240g in the described Chinese medicine composition additive, Rhizoma Wenyujin Concisum 270g ~ 290g, Radix Paeoniae Alba 450g ~ 470g, Cortex Magnoliae Officinalis 180g ~ 200g, Radix Salviae Miltiorrhizae 350g ~ 370g, Rhizoma Anemones Altaicae 410g ~ 430g, Rhizoma Alismatis 260g ~ 280g, Herba Silybi mariani 160g ~ 180g, Fructus Dracontomeli Duperreani 210g ~ 230g, DABAIJIE potato 310g ~ 330g, GAMBIER 300g ~ 320g, Radix Clematidis 390g ~ 410g, Caulis Piperis Kadsurae 200g ~ 220g, Resina Ferulae 270g ~ 290g, Semen Raphani 330g ~ 350g, Herba Selaginellae 260g ~ 280g, Radix Astragali 490g ~ 510g, Rhizoma Dioscoreae 220g ~ 240g, Radix Glycyrrhizae 180g ~ 200g and Semen Nelumbinis 220g ~ 240g.
10. the preparation method of the described feedstuff of claim 6 to 9 is characterized in that, is specially:
The first step, the preparation of described Chinese medicine composition additive, the Radix Paeoniae Alba, Rhizoma Anemones Altaicae, Fructus Dracontomeli Duperreani, DABAIJIE potato, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae and Semen Nelumbinis are mixed by above-mentioned weight proportion, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with 60 ℃ of Chinese liquor, the addition of Chinese liquor did not have fine powder, and liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and remove supernatant then, the liquid that stays is put into oven for drying, makes first powder; Temperature at oven drying is 105 ℃, and drying time, 15～25min mixed remaining crude drug component by weight ratio, send into and be ground into fine powder in the pulverizer, add the water with respect to 3 ~ 5 times of fine powder quality, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds the water with quality such as front again, decocts 1 ~ 2 hour, decoction liquor is filtered, and filtrate is mixed, and concentrates, except anhydrating, drying is pulverized, obtain second powder, with first powder and second powder mixes, obtain the Chinese medicine composition additive;
Second step; ratio is got major ingredient and described Chinese medicine composition additive combination to together by weight; putting into multiplex mixer stirred 150 minutes; put into the ring mode pulverizer after the taking-up and be ground into powder; take out then and put into dehydrator; the aridity of control dried material is 77% ~ 85%; the time of smoking is 50 ~ 70 minutes; putting into multiplex mixer after removal and cooling stirred 200 minutes; it is expanded to put into the ring mode bulking machine after the taking-up; the temperature of control bulking machine is between 70 ℃-80 ℃; the expanded time is 1 ~ 2 hour, and the aridity of control material to be extruded is 80% ~ 90%, changes over to after the taking-up and produces precipitation hard particles feedstuff in the ring mode grit machine; sieve with 80 meshes then, can pack by required weight.
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