CN103239677B - 一种用于治疗腹水的肛肠用药及其制剂的制备方法 - Google Patents
一种用于治疗腹水的肛肠用药及其制剂的制备方法 Download PDFInfo
- Publication number
- CN103239677B CN103239677B CN201310161934.9A CN201310161934A CN103239677B CN 103239677 B CN103239677 B CN 103239677B CN 201310161934 A CN201310161934 A CN 201310161934A CN 103239677 B CN103239677 B CN 103239677B
- Authority
- CN
- China
- Prior art keywords
- parts
- ascites
- chinese medicine
- treatment
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010003445 Ascites Diseases 0.000 title claims abstract description 44
- 239000003814 drug Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 238000000227 grinding Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 5
- 241001489978 Eupolyphaga Species 0.000 claims description 12
- 241000972155 Moschus Species 0.000 claims description 12
- 238000007654 immersion Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000219506 Phytolacca Species 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000829 suppository Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 239000002511 suppository base Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 241000402754 Erythranthe moschata Species 0.000 abstract 3
- 238000002156 mixing Methods 0.000 abstract 2
- 241000758794 Asarum Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 241000701408 Euphorbia kansui Species 0.000 abstract 1
- 240000007643 Phytolacca americana Species 0.000 abstract 1
- 235000009074 Phytolacca americana Nutrition 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 9
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 206010011224 Cough Diseases 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 206010010774 Constipation Diseases 0.000 description 5
- 206010016807 Fluid retention Diseases 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 5
- 230000001882 diuretic effect Effects 0.000 description 5
- 230000003187 abdominal effect Effects 0.000 description 4
- 239000002934 diuretic Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 210000004303 peritoneum Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 208000004371 toothache Diseases 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 2
- 206010027336 Menstruation delayed Diseases 0.000 description 2
- 206010028748 Nasal obstruction Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 229940126701 oral medication Drugs 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 201000009890 sinusitis Diseases 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241001415830 Bubo Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010055690 Foetal death Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 208000034767 Hypoproteinaemia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010031256 Osteomyelitis chronic Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010039759 Scrotal swelling Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 229960002478 aldosterone Drugs 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 208000016335 bubo Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000002016 colloidosmotic effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000003664 filaricide agent Substances 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000032630 lymph circulation Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 201000002513 peritoneal mesothelioma Diseases 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 208000007232 portal hypertension Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000004441 taeniasis Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000002978 thoracic duct Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种治疗腹水的肛肠用药的中药组合物及其制剂的制备方法。中药组合物原料成分为麝香0.1-0.2份蟾酥0.05-0.1份甘遂3-5份牵牛子2-4份细辛2-4份莪术10-15份土元8-12份蜂房10-15份商陆8-10份。其中,麝香蟾酥粉碎,其余药物混合后粉碎，煎煮过滤后的滤液及洗涤后得到的滤液合并，使水分全部蒸发,冷却，与麝香蟾酥合并；混合研磨，得到粉剂。本发明本品用于直肠吸收，特别对晚期腹水患者对口服中药不能耐受者，开辟了很好的用药途径，对胃肠无刺激性，效果明显，应用简单，值得推广应用。
Description
技术领域
本发明涉及一种用于治疗腹水的肛肠用药及其制剂的制备方法，属于中医药领域。
背景技术
腹水是临床上常见的疾病之一，是临床上难治性疾病。多有心血管疾病、 肝脏疾病（病毒性肝炎、肝硬化、肝脏肿瘤、肝脏血管疾病）、腹膜肿瘤 腹膜的转移瘤、腹膜间皮瘤。慢性肾炎肾病型 肾病综合征等引起的，其中肝脏肿瘤引起的腹水临床比较常见，也比较难以治疗。腹水形成的其中原因之一是由于细胞外液量增多--钠水潴留所致。钠水潴留的基本机理是球一管失平衡而导致的肾排钠和排水减少。血管内外液体交换失衡导致组织间液增多：( 一)毛细血管有效流体静压增高（二）有效胶体渗透压下降。
肝硬化腹水,形成的机理较为复杂。腹水形成的主要因素有门静脉高压引起的循环动力学改变。淋巴循环障碍、低蛋白血症、继发性的肾功能障碍以及醛固酮和抗利尿激素的增加。目前有三种学说可用来解释腹水发生机理。即充盈不足学说、泛溢学说及周围动脉扩张学说。腹膜疾病引起的腹水 是由于腹膜的炎性渗出及恶性肿瘤的浸润所致。乳糜性腹水是由于胸导管阻塞所致，多见于丝虫病。
目前对于腹水的治疗尚无特殊的方法和特效的药物,多选择利尿药物，由于腹水吸收量每日不超过900ml，因此利尿不宜过猛，当利尿效果不佳时，可配合应用导泻剂，如口服甘露醇等，利尿剂无效时，则选择腹腔穿刺，特点是因腹压降低而使腹水迅速生成。而口服药物治疗副作用大，疗效欠佳，对胃肠刺激性大。近几年来，中医治疗腹水取得了很大成绩，突出在于较为***地研究了腹水的临床疗效及作用机理，且应用中医药治疗本病无毒副作用，获得了满意的效果，而临床上肛肠用药对胃肠无刺激性，应用方便，为晚期腹水不能口服药物的患者提供了很好的应用空间，并取得了较好的疗效。
发明内容
本发明要解决的问题是提供一种用于治疗腹水的肛肠用药及其制剂的制备方法。
本发明的技术方案是：
一种用于治疗腹水的的肛肠用药的中药组合物，由以下重量份的原材料制成：
麝香0.1-0.2份 蟾酥0.05-0.1份 甘遂3-5份 牵牛子2-4份 细辛2-4份 莪术10-15份 土元8-12份 蜂房 10-15份 商陆6-10份。
作为上述技术方案的进一步优选，所述中药组合物由以下重量份的原材料制成：
麝香0.15份 蟾酥0.07份 甘遂4份 牵牛子3份 细辛3份 莪术12份 土元10份 蜂房 12份 商陆8份。
根据本发明，一种治疗的治疗腹水的肛肠用药的制备方法：
包括以下步骤：
a、按照甘遂 牵牛子 细辛 莪术 土元 蜂房 商陆的比例取各原材料成分；
b、把步骤a的原材料粉碎后加入蒸馏水浸泡30-60分钟后煎煮，过滤挤干，残渣用热水洗涤2-3次，将煎煮过滤后的滤液及洗涤后得到的滤液合并，放入蒸发器皿中，在小火上缓慢加热，使水分全部蒸发，再冷却，将提取物晾干，粉碎，备用；
c、将麝香 蟾酥加工成成200目的细粉，备用；
d、将步骤b和步骤c粉碎后的制备物进行混合研磨，得到治疗腹水的中药粉粒；
e、将栓剂基质利用水浴法融化后，与步骤d得到的中药粉粒混合，保温灌模,制成治疗腹水的中药栓剂。
在以上原料中，
麝香功用开窍醒神，活血散结，催产下胎。用于温热病神昏痉厥及中风痰厥、气厥等闭证。心脉瘀阻所致的心痛。痈疽疮疡，跌打损伤，痹证及经闭，胎死腹中，胞衣不下。
蟾酥的功效解毒，消肿，强心，止痛。治疔疮，痈疽，发背，瘰疬，慢性骨髓炎，咽喉肿痛，小儿疳积，心衰，风、虫牙痛。
甘遂泻水逐饮；破积通便。主水肿；腹水；留饮结胸；癫痫；喘咳；大小便不通。用于水肿胀满，胸腹积水，痰饮积聚，气逆喘咳，二便不利。
牵牛子功效利水通便；祛痰逐饮；消积杀虫。主水肿；腹水；脚气；痰壅喘咳；大便秘结；食滞虫积；腰痛；阴囊肿胀；痈疽肿毒；痔漏便毒等。用于水肿胀满，二便不通，痰饮积聚，气逆喘咳，虫积腹痛，蛔虫、绦虫病。
细辛功效散寒祛风；止痛；温肺化饮；通窍。主风寒表证；头痛，牙痛；风湿痹痛；痰饮咳喘；鼻塞；鼻渊；口疮。用于风寒感冒，头痛，牙痛，鼻塞鼻渊，风湿痹痛，痰饮喘咳。
莪术行气破血；消积止痛。主血气心痛；饮食积滞；脘腹胀痛；血滞经闭；痛经；症瘕瘤痞块；跌打损伤。
土元功效破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块
蜂房祛风，功毒，杀虫，止痛。用于龋齿牙痛，疮疡肿毒，乳痈，瘰疬，皮肤顽癣，鹅掌风。
商陆通二便，泻水，散结。治水肿，胀满，脚气，喉痹，痈肿，恶疮。
腹水中医认为其基本病机为久病体虚，正不胜邪而致水湿停留，属于“鼓胀”、“水鼓”范畴，其主要发病的机理与饮食、情志、黄疸积聚等有关。本发明应用麝香、 蟾酥开窍消肿止痛，甘遂 牵牛子 商陆利水通便 ，使水湿从二便排出 细辛化饮止痛，莪术 土元行气破血止痛消肿，蜂房消肿止痛散瘀结。本品用于直肠吸收，特别对晚期腹水患者对口服中药不能耐受者，开辟了很好的用药途径，对胃肠无刺激性，效果明显，应用简单，值得推广应用。
具体实施方式
下面结合实施例对本发明作进一步说明:
实施例1
一种用于治疗腹水的中药组合物，原材料重量份为：麝香0.15份 蟾酥0.07份 甘遂4份 牵牛子3份 细辛3份 莪术12份 土元10份 蜂房 12份 商陆8份。
制备方法,包括以下步骤：
a、按照甘遂4份 牵牛子3份 细辛3份 莪术12份 土元10份 蜂房 12份 商陆8份比例取各原材料成分；
b、把步骤a的原材料粉碎后加入蒸馏水浸泡30-60分钟后煎煮，过滤挤干，残渣用热水洗涤2-3次，将煎煮过滤后的滤液及洗涤后得到的滤液合并，放入蒸发器皿中，在小火上缓慢加热，使水分全部蒸发，再冷却，将提取物晾干，粉碎，备用；
c、将麝香 蟾酥加工成成200目的细粉，备用；
d、将步骤b和步骤c粉碎后的制备物进行混合研磨，得到治疗腹水的中药粉粒；
e、将栓剂基质利用水浴法融化后，与步骤d得到的中药粉粒混合，保温灌模,制成治疗腹水的中药栓剂。
实施例2
一种用于治疗腹水的中药组合物，原材料重量份为：麝香0.1份 蟾酥0.05份 甘遂3份 牵牛子2份 细辛2份 莪术10份 土元8份 蜂房 10份 商陆6份。
制备方法, 包括以下步骤：
a、按照甘遂3份 牵牛子2份 细辛2份 莪术10份 土元8份 蜂房 10份 商陆6份比例取各原材料成分；
b、把步骤a的原材料粉碎后加入蒸馏水浸泡30-60分钟后煎煮，过滤挤干，残渣用热水洗涤2-3次，将煎煮过滤后的滤液及洗涤后得到的滤液合并，放入蒸发器皿中，在小火上缓慢加热，使水分全部蒸发，再冷却，将提取物晾干，粉碎，备用；
c、将麝香 蟾酥加工成成200目的细粉，备用；
d、将步骤b和步骤c粉碎后的制备物进行混合研磨，得到治疗腹水的中药粉粒；
将栓剂基质利用水浴法融化后，与步骤d得到的中药粉粒混合，保温灌模,制成治疗腹水的中药栓剂。
选取200例腹水患者，随机选取100例作为治疗组，另外100例作为对照组，其中200例患者分为治疗组1、治疗组2，每个治疗组随机选取的100例患者，治疗组1使用本发明实施例1制备的栓剂进行治疗，治疗组2使用本发明实施例2制备的栓剂进行治疗，每次一粒，每天两次
对照组的患者采用静推速尿 10mg-60mg，5天为一周期观察治疗效果。
以腹部彩超观察腹水量的多少，显效为彩超明显观察腹水减少，好转为患者自觉腹部胀满减轻，
治疗结果如下表：
| 对比组别（例） | 显效 | 好转 | 无效 | 显效率 | 有效率 |
| 治疗组1 | 87例 | 11例 | 2例 | 87﹪ | 98﹪ |
| 治疗组2 | 86例 | 12例 | 2例 | 86﹪ | 98﹪ |
| 对照组 | 67例 | 22例 | 11例 | 67﹪ | 89﹪ |
从以上数据表可以看出，治疗组1无效2例,占2﹪，显效87例，占87﹪，,有效率98例，总有效率98﹪。治疗组2无效2例，占2﹪,显效86例，占86％，有效率98％，总有效率98﹪ 对照组无效有11例，占67％，显效67例，占67﹪,,有效率89％，综上表所知， 治疗组1的治愈率显效率高于其余治疗组2，综上所述治疗组1组方最为有效。
Claims (3)
1.一种用于治疗腹水的肛肠用药的中药组合物，其特征是：由以下重量份的原材料制成：麝香0.1-0.2份 蟾酥0.05-0.1份 甘遂3-5份 牵牛子2-4份 细辛2-4份 莪术10-15份 土元8-12份 蜂房 10-15份 商陆6-10份。
2.如权利要求1所述的治疗腹水的肛肠用药的中药组合物，其特征是：由以下重量份的的原材料制成：麝香0.15份 蟾酥0.07份 甘遂4份 牵牛子3份 细辛3份 莪术12份 土元10份 蜂房 12份 商陆8份。
3.一种权利要求1或2所述的用于治疗腹水的肛肠用药的中药组合物的制备方法，包括以下步骤：
a、按照甘遂 牵牛子 细辛 莪术 土元 蜂房 商陆的比例取各原材料成分；
b、把步骤a的原材料粉碎后加入蒸馏水浸泡30-60分钟后煎煮，过滤挤干，残渣用热水洗涤2-3次，将煎煮过滤后的滤液及洗涤后得到的滤液合并，放入蒸发器皿中，在小火上缓慢加热，使水分全部蒸发，再冷却，将提取物晾干，粉碎，备用；
c、将麝香 蟾酥加工成200目的细粉，备用；
d、将步骤b和步骤c粉碎后的制备物进行混合研磨，得到治疗腹水的中药粉粒。
e、将栓剂基质利用水浴法融化后，与步骤d得到的中药粉粒混合，保温灌模,制成治疗腹水的中药栓剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161934.9A CN103239677B (zh) | 2013-05-06 | 2013-05-06 | 一种用于治疗腹水的肛肠用药及其制剂的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310161934.9A CN103239677B (zh) | 2013-05-06 | 2013-05-06 | 一种用于治疗腹水的肛肠用药及其制剂的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103239677A CN103239677A (zh) | 2013-08-14 |
| CN103239677B true CN103239677B (zh) | 2015-03-04 |
Family
ID=48919780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310161934.9A Expired - Fee Related CN103239677B (zh) | 2013-05-06 | 2013-05-06 | 一种用于治疗腹水的肛肠用药及其制剂的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103239677B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260309A (zh) * | 2018-11-20 | 2019-01-25 | 山东罗欣乐康制药有限公司 | 一种温中止痛的中药组合物颗粒剂的制备方法 |
| CN112516189A (zh) * | 2021-01-21 | 2021-03-19 | 朱培于 | 一种治疗肝腹水的药物及制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184656C (zh) * | 2000-11-30 | 2005-01-12 | 国际商业机器公司 | 多位置微机电开关 |
| CN101850096B (zh) * | 2010-01-19 | 2012-04-18 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗脑积水的外用中药组合物及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184656A (zh) * | 1997-07-09 | 1998-06-17 | 迟经惠 | 肝肾消臌膏 |
-
2013
- 2013-05-06 CN CN201310161934.9A patent/CN103239677B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184656C (zh) * | 2000-11-30 | 2005-01-12 | 国际商业机器公司 | 多位置微机电开关 |
| CN101850096B (zh) * | 2010-01-19 | 2012-04-18 | 泰一和浦（北京）中医药研究院有限公司 | 一种治疗脑积水的外用中药组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 肝硬化腹水中医外治近况;程志文等;《中医外治杂志》;20091231;第18卷(第6期);45页左栏第33行-36行 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103239677A (zh) | 2013-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101884770B (zh) | 治疗尿石症的中药制剂及其制备方法 | |
| CN100417403C (zh) | 治疗癌症的中药 | |
| CN103520680B (zh) | 治疗急性心衰的中药 | |
| CN102908606A (zh) | 一种治疗妊娠呕吐的中药 | |
| CN103830632A (zh) | 一种根治银屑病等多种皮肤病的中药制剂及其制备方法与应用 | |
| CN102188685B (zh) | 一种治疗腹泻型肠易激综合征的中药外敷散剂及其制备方法 | |
| CN103690889B (zh) | 一种治疗胃癌的中药汤剂 | |
| CN101095923A (zh) | 一种治疗***的中药 | |
| CN102824445B (zh) | 一种治疗十二指肠溃疡的中药组合物 | |
| CN103239677B (zh) | 一种用于治疗腹水的肛肠用药及其制剂的制备方法 | |
| CN103330872B (zh) | 一种蛇伤康复药的制备方法 | |
| CN102755515B (zh) | 治疗乳腺增生的中药汤剂 | |
| CN103908581A (zh) | 一种治疗膀胱癌的药物及制备方法 | |
| CN103330873A (zh) | 一种蛇伤康复药 | |
| CN101961455A (zh) | 一种治疗慢性结肠炎疾病的中药 | |
| CN111973720A (zh) | 一种治疗乳腺炎、乳腺增生的中药组合物及其制备方法 | |
| CN102861292B (zh) | 一种治疗食管癌的药物及其制备方法 | |
| CN102600427B (zh) | 一种治疗乳腺增生、乳腺癌的中药组合物 | |
| CN103520638B (zh) | 一种治疗***肥大症的中药复方组合物及其制备方法及其应用 | |
| CN101940709B (zh) | 治疗胃脘痛的中药 | |
| CN105343707A (zh) | 一种治疗离心性环状红斑的中药 | |
| CN102580008B (zh) | 一种治疗胃脘痛的中药 | |
| CN105288528A (zh) | 一种治疗脾胃不和药酒 | |
| CN111671862A (zh) | 一种治疗恶性肿瘤的中药复方制剂及其制备方法 | |
| CN104435117A (zh) | 一种治疗***瘤的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHONGXIN HOSPITAL, QINGDAO Free format text: FORMER OWNER: SUN FENGQING Effective date: 20150127 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Mei Xiqing Inventor after: Dong Shaoan Inventor after: Lu Ruizhen Inventor after: Wu Jun Inventor before: Sun Fengqing Inventor before: Wang Xiaohui Inventor before: Yu Jiantao Inventor before: Wang Jianling |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SUN FENGQING WANG XIAOHUI YU JIANTAO WANG JIANLING TO: MEI XIQING DONG SHAOAN LU RUIZHEN WU JUN Free format text: CORRECT: ADDRESS; FROM: 265100 YANTAI, SHANDONG PROVINCE TO: 266042 QINGDAO, SHANDONG PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20150127 Address after: 266042 No. four, No. 127 South Road, Shandong, Qingdao Applicant after: Zhongxin Hospital, Qingdao Address before: The third people's Hospital of Haiyang City, No. 3 265100 Shandong city of Yantai province Haiyang City Hai Hua Lu Applicant before: Sun Fengqing |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150304 Termination date: 20160506 |