CN103239583B - Airuike heart-soothing granule - Google Patents

Abstract

The invention provides a traditional Chinese medicine granule for treating coronary heart disease, which is prepared from rhubarb processed with wine, prepared monkshood, longspur epimedium, rhodiola rosea, leech, dragon's blood, glossy privet fruit, Chinese angelica root-tail and lucid ganoderma. The method comprises the following steps: grinding the prepared leech and dragon's blood into fine powder with the particle size of 120 meshes for later use; adding water to decoct the prepared rhubarb processed with wine, prepared monkshood, longspur epimedium, rhodiola rosea, glossy privet fruit, Chinese angelica root-tail and lucid ganoderma twice, mixing the decocting solution obtained by twice extraction and filtering, wherein the filtrate is for later use; concentrating the filtrate in a concentrating tank, concentrating the filtrate into paste, adding the ground fine powder of the leech and dragon's blood, drying at low temperature of 100 DEG C; and finally crushing to pass through a 60-mesh sieve to obtain the granules, and packaging the granules, wherein every 10g of granule is packaged in one bag. The granule is reasonable in preparation structure and precise and appropriate in medicine compatibility, does not have an obvious toxic or side effect, has the effects of promoting blood circulation to remove blood stasis, relieving the chest and regulating vital energy and warming yang and alleviating pain and is mainly used for treating coronary arteriosclerotic cardiopathy, angina pectoris and myocardial infarction sequelae.

Description

A kind of Chinese medicinal granule for the treatment of coronary heart disease

Technical field

The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicinal granule for the treatment of coronary heart disease and preparation method thereof.

Background technology

Coronary heart disease is a kind of cardiovascular disease of serious harm human body health, is commonly encountered diseases, frequently-occurring disease clinically.According to incompletely statistics, China's coronary heart disease death rate, in growth trend year by year, is therefore the important problem of of medical domain with Chinese medicine to the Therapy study of coronary heart disease and Prevention Research.In recent years, Chinese medicine obtains incremental advances in treatment primary disease, becomes one of means of the Comprehensive Treatment of coronary heart disease.In view of coronary heart disease is common clinical, frequently-occurring disease, strengthen the top priority its Therapy study having been become to clinical workers.

Treating coronary disease with traditional Chinese medicine angina cordis has quiet long history and rich experience.The organic conception of the traditional Chinese medical science, distinguish disease treating, treatment that the advantage such as effectiveness, innocuousness, persistence, multiformity of dynamic equilibrium and Chinese medicine treatment primary disease is suitable for complicated and diversified coronary heart disease.Multidirectional research is observed and was already confirmed, in transmission symptom, reduces recurrence, and aspect of improving the quality of living Chinese medicine doctor determined curative effect is obvious.Long-term taking Chinese medicine can be resided and be prevented, in controlling, integrating prevention, treatment, rehabilitation, is that Current therapeutic coronary heart disease obtains some and breaks through one of most promising method.Therefore, give full play to the advantage of motherland's medical science, in conjunction with modern study achievement, seek and develop effective prescription for the treatment of coronary heart disease, there is very important theory significance and use value.

Summary of the invention

Object of the present invention is just to provide a kind ofly treats the Chinese medicine preparation that coronary heart disease has obvious curative effects.Object of the present invention realizes by following scheme: the Chinese medicinal granule for the treatment of coronary heart disease of the present invention, is that the preparation of raw material being weight portion by following dosage forms:

Radix et Rhizoma Rhei (processed with wine) 3-8, Radix Aconiti Lateralis Preparata 8-15, Herba Epimedii 13-20, Radix Rhodiolae 12-17, Hirudo 3-8, Sanguis Draxonis 1-4, Fructus Ligustri Lucidi 12-19, Radix Angelicae Sinensis 12-19, Ganoderma 8-15.

The preferential proportioning of raw material dosage described above is as follows:

Radix et Rhizoma Rhei (processed with wine) 4.5-6.5, Radix Aconiti Lateralis Preparata 9-12, Herba Epimedii 15-18, Radix Rhodiolae 13-16, Hirudo 4-6, Sanguis Draxonis 2-3, Fructus Ligustri Lucidi 13-17, Radix Angelicae Sinensis 13-17, Ganoderma 9-12.

Raw material dosage optimal proportion described above is as follows:

Radix et Rhizoma Rhei (processed with wine) 5, Radix Aconiti Lateralis Preparata 10.5, Herba Epimedii 17.5, Radix Rhodiolae 15.5, Hirudo 5.5, Sanguis Draxonis 2.5, Fructus Ligustri Lucidi 16.5, Radix Angelicae Sinensis 16.5, Ganoderma 10.5.

Preparation method of the present invention is as follows: the Hirudo first will prepared, it is for subsequent use that Sanguis Draxonis is ground into fine powder (120 order), the Radix et Rhizoma Rhei (processed with wine) will prepared again, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, Ganoderma decocts with water twice, it is Radix et Rhizoma Rhei (processed with wine) that first time decocts water consumption, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, 3-5 times of Ganoderma gross weight, decocting time is 40 minutes, it is Radix et Rhizoma Rhei (processed with wine) that second time decocts water consumption, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the 3-4 of Ganoderma gross weight doubly, decocting time 30 minutes, decoct extracting solution by twice and merge filtration, filtrate is for subsequent use, filtrate is put into concentration tank concentrate, be condensed into after paste again by Hirudo, the fine powder that Sanguis Draxonis is ground into adds, then 100 degree of oven drying at low temperatures are carried out, finally pulverize 60 orders and obtain granule of the present invention, granule is packed, 10 grams every bag.

The full square structure of the present invention is reasonable, and compatibility is precise and appropriate, and without obvious toxic-side effects, have blood circulation promoting and blood stasis dispelling, the chest stuffiness relieving is regulated the flow of vital energy, effect of warming YANG analgesia, is mainly used in treating coronary atherosclerotic heart disease, angina pectoris, myocardial infarction sequela.

The present invention cures the disease the clinical report of coronary heart disease:

1, clinical data:

Treatment group 50 example, wherein man 32 example, female 18 example, age 42-76 year, 59 years old mean age, effort angina 31 example, non-effort angina 19 example, complicated hypertension 10 example, diabetes 4 example, arrhythmia 3 example, slight 10 examples, moderate 35 example, severe 5 example.

Matched group 30 example, wherein man 20 example, female 10 example, age 40-70 year, 55 years old mean age, effort angina 19 example, non-effort angina 11 example, complicated hypertension 6 example, diabetes 3 example, arrhythmia 4 example, slight 6 examples, moderate 22 example, severe 2 example.

Two groups of age of onset, types of pain and degree all have comparability (P>0.05).

Diagnosis was with reference to national internal medicine academic conference in 1980, " suggestion of coronary heart disease name and diagnostic criteria " diagnosis and typing [CHINESE JOURNAL OF INTERNAL MEDICINE 1981,20(4): 253], selection has angina cordis recurrent exerbation, routine electrocardiogram has ischemic ST-T changer, all cases all has the cardiopalmus of varying degree, breathes hard, uncomfortable in chest and chest pain and the person of making a definite diagnosis.

2, Therapeutic Method:

Treatment group adopts Chinese medicinal granule of the present invention, each 1 bag, every day 3 times, and putting after melting by warm water in glass and take, 30 days is a course for the treatment of.

Matched group each oral sorbitrate 10 mg, persantin 50mg, every day 3 times 30 days is a course for the treatment of.

Two groups of period in a medicine are all stopped using, and other treats angina pectoris medicine, evaluates curative effect after the course for the treatment of.

, therapeutic outcome:

3.1 criterions of therapeutical effect:

Effective: after 1 course for the treatment of, each symptom, sign disappear and ECG ST-T recovers normal.

Take a turn for the better: after 1 course for the treatment of, clinical symptoms, sign obviously alleviate or disappear, reduction more than the rise 0.05mv after the treatment of ECG ST-T section, but do not reach normal level.

Invalid: after 1 course for the treatment of, clinical symptoms and electrocardiogram are without any change.

3.2 results:

In treatment group 50 example, effective 40 examples, take a turn for the better 10 examples, total effective rate 100%.

In matched group 30 example, effective 8 examples, take a turn for the better 18 examples, invalid 4 examples, total effective rate 86.6%.

Two groups of comparison therapy group total effective rates are obviously better than matched group (P<0.01).

Claims (3)

1. treat a Chinese medicinal granule for coronary heart disease, the preparation of raw material that to it is characterized in that by following dosage be weight portion forms:

Radix et Rhizoma Rhei (processed with wine) 3-8, Radix Aconiti Lateralis Preparata 8-15, Herba Epimedii 13-20, Radix Rhodiolae 12-17, Hirudo 3-8, Sanguis Draxonis 1-4, Fructus Ligustri Lucidi 12-19, Radix Angelicae Sinensis 12-19, Ganoderma 8-15, manufacturing process is as follows: the Hirudo first will prepared, and it is for subsequent use that Sanguis Draxonis is ground into fine powder, the Radix et Rhizoma Rhei (processed with wine) will prepared again, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, Ganoderma decocts with water twice, it is Radix et Rhizoma Rhei (processed with wine) that first time decocts water consumption, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, 3-5 times of Ganoderma gross weight, decocting time is 40 minutes, it is Radix et Rhizoma Rhei (processed with wine) that second time decocts water consumption, Radix Aconiti Lateralis Preparata, Herba Epimedii, Radix Rhodiolae, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the 3-4 of Ganoderma gross weight doubly, decocting time 30 minutes, decoct extracting solution by twice and merge filtration, filtrate is for subsequent use, filtrate is put into concentration tank concentrate, be condensed into after paste again by Hirudo, the fine powder that Sanguis Draxonis is ground into adds, then 100 degree of oven drying at low temperatures are carried out, finally pulverize 60 orders and obtain granule.

2. the Chinese medicinal granule for the treatment of coronary heart disease according to claim 1, is characterized in that the preferential proportioning of described raw material dosage is as follows:

Radix et Rhizoma Rhei (processed with wine) 4.5-6.5, Radix Aconiti Lateralis Preparata 9-12, Herba Epimedii 15-18, Radix Rhodiolae 13-16, Hirudo 4-6, Sanguis Draxonis 2-3, Fructus Ligustri Lucidi 13-17, Radix Angelicae Sinensis 13-17, Ganoderma 9-12.

3. the Chinese medicinal granule for the treatment of coronary heart disease according to claim 1, is characterized in that described raw material dosage optimal proportion is as follows:

Radix et Rhizoma Rhei (processed with wine) 5, Radix Aconiti Lateralis Preparata 10.5, Herba Epimedii 17.5, Radix Rhodiolae 15.5, Hirudo 5.5, Sanguis Draxonis 2.5, Fructus Ligustri Lucidi 16.5, Radix Angelicae Sinensis 16.5, Ganoderma 10.5.