CN103211892B - Chinese medicinal composition for treating insomnia - Google Patents

Chinese medicinal composition for treating insomnia Download PDF

Info

Publication number
CN103211892B
CN103211892B CN201310093131.4A CN201310093131A CN103211892B CN 103211892 B CN103211892 B CN 103211892B CN 201310093131 A CN201310093131 A CN 201310093131A CN 103211892 B CN103211892 B CN 103211892B
Authority
CN
China
Prior art keywords
parts
radix
chinese medicinal
medicinal composition
insomnia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201310093131.4A
Other languages
Chinese (zh)
Other versions
CN103211892A (en
Inventor
赵霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201310093131.4A priority Critical patent/CN103211892B/en
Publication of CN103211892A publication Critical patent/CN103211892A/en
Application granted granted Critical
Publication of CN103211892B publication Critical patent/CN103211892B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a Chinese medicinal composition for treating insomnia. The Chinese medicinal composition is made of the following Chinese medicinal materials by weight: 5-15 parts of cortex moutan, 5-15 parts of radix bupleuri, 5-15 parts of Fructus Gardeniae, 5-15 parts of bighead atractylodes rhizome, 20-40 parts of dragon bones, 20-40 parts of oysters, 10-20 parts of poria with hostwood, 40-60 parts of spina date seeds, 5-15 parts of polygala tenuifolia, 5-15 parts of platycladi seeds, 20-40 parts of Salvia miltiorrhiza, 5-15 parts of liquorice, 20-40 parts of Tuber Fleeceflower Stems, 20-40 parts of cortex albiziae, 10-20 parts of Codonopsis pilosula, 10-20 parts of Angelica sinensis, 10-20 parts of white paeony roots, and 10-30 parts of Radix Astragali preparata. With the efficacy of nourishing liver and arresting sweating, tranquilizing the mind and soothing the nerves, the Chinese medicinal composition has obvious insomnia treatment effects and reliable functions. The Chinese medicinal composition disclosed in the invention has the characteristics of wide ingredient medicine sources, simple preparation, and no toxic or side effect.

Description

A kind of Chinese medicine composition of Cure for insomnia
Technical field
The present invention relates to a kind of medicinal preparation of not determining structure of traditional herbal medicines, especially a kind of Chinese medicine composition of Cure for insomnia.
Background technology
Insomnia is sleep disorder, is one of common clinical disease.Show as difficulty falling asleep, intermittently discontinuous, and wake up prematurely, after waking up, can not continue again to sleep, do not have enough sleep, malaise, asthenia sensation, how because health condition is not good, pain, do not feel like oneself, circadian rhythm is upset, and sleep environment impact etc. also have and are afraid of sleep and insomnia.Main manifestations be the not enough of the length of one's sleep, the degree of depth and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy be insomnia all night.Though insomnia does not belong to critical illness, hinder people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient.Western medical treatment sleep adopts sleeping pill, but the sleep of taking after sleeping pill is different from physiologic sleep, but passive sleep easily forms the dependence to the medicine of sleeping peacefully, and the long-term taking medicine of sleeping peacefully can cause iatrogenic disease.
The traditional Chinese medical science thinks, insomnia is due to feelings will, diet internal injury, or after being ill and old, innate deficiency, the causes of disease such as timidness due to deficiency of the heart, cause lack of preservation of spirit or irritability.How because disturbing in pathogenic fire derived from stagnation of liver-QI, expectorant heat, the many reasons such as hyperactivity of fire caused by deficiency of YIN, deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy.
According to theory of Chinese medical science, for the pathogeny of insomnia, carry out dialectical composition of prescription, to reach the object for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind ofly prepare conveniently, medicine source is wide, cost is low, the Chinese medicine composition of evident in efficacy, reliable effect, the Cure for insomnia that has no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition of Cure for insomnia, it is characterized in that: it is to be made up of the raw material of Chinese medicine of following weight portion proportioning: Cortex Moutan 5-15 part, Radix Bupleuri 5-15 part, Fructus Gardeniae 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Os Draconis 20-40 part, Concha Ostreae 20-40 part, Poria cum Radix Pini 10-20 part, Semen Ziziphi Spinosae 40-60 part, Radix Polygalae 5-15 part, Semen Platycladi 5-15 part, Radix Salviae Miltiorrhizae 20-40 part, Radix Glycyrrhizae 5-15 part, Caulis Polygoni Multiflori 20-40 part, Cortex Albiziae 20-40 part, Radix Codonopsis 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Astragali Preparata 10-30 part.
The preferred technical solution of the present invention is: a kind of Chinese medicine composition of Cure for insomnia, is characterized in that: it is to be made up of the raw material of Chinese medicine of following weight portion proportioning: 10 parts of Cortex Moutans, 10 parts of Radix Bupleuri, 10 parts of Fructus Gardeniaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Os Draconis, 30 parts of Concha Ostreaes, 15 parts of Poria cum Radix Pinis, 50 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Polygalaes, 10 parts of Semen Platycladi, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts, Radix Glycyrrhizae, 30 parts of Caulis Polygoni Multiflori, 30 parts of Cortex Albiziaes, 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 20 parts of Radix Astragali Preparatas.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In Chinese medicine composition of the present invention: Cortex Moutan has effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; Radix Bupleuri have evacuate bring down a fever, effect of yang invigorating soothing liver-QI; Fructus Gardeniae has effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, the antiabortive effect of hidroschesis; Os Draconis have effect of tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing; Effect of Concha Ostreae convergence calmness, YANG hyperactivity suppressing arresting seminal emission, resolving phlegm and softening hard masses; Removing toxic substances is eased pain, is had suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, and hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating effect; Poria cum Radix Pini has effect of eliminating dampness and diuresis, calming heart and tranquilizing mind; Poria cum Radix Pini has effect of eliminating dampness and diuresis, calming heart and tranquilizing mind; Semen Ziziphi Spinosae has effect of nourishing the liver arresting sweating, mind tranquilizing and the heart calming; Radix Polygalae has the Fructus Alpiniae Oxyphyllae of calming the nerves, relieving convulsion, the loose strongly fragrant effect of circulation of qi promoting of eliminating the phlegm; Semen Platycladi has effect of tranquilizing by nourishing the heart, nourishing YIN and benefiting blood; Radix Salviae Miltiorrhizae has effect of promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription; Caulis Polygoni Multiflori has effect of tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral; Cortex Albiziae has effect of resolving stagnation for tranquilization, promoting blood circulation and detumescence; Radix Codonopsis has effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Radix Angelicae Sinensis have enrich blood invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; The Radix Paeoniae Alba has effect of nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receipts antiperspirant; Radix Astragali Mongolici (processed) has effect of invigorating the spleen and replenishing QI yang invigorating.Drug component in the present composition is through dialectical compatibility, complements each other using, and has synergism, plays altogether effect of nourishing the liver arresting sweating, mind tranquilizing and the heart calming, insomnia reached to the object for the treatment of both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the use that is decocted in water for oral dose.Through clinical practice checking, it is evident in efficacy, reliable effect, and the property of medicine is gentle, does not occur toxic and side effects, total effective rate 95%, cure rate reaches 82%.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A Chinese medicine composition for Cure for insomnia, it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 10g, Radix Bupleuri 10g, Fructus Gardeniae 10g, Rhizoma Atractylodis Macrocephalae 10g, Os Draconis 30g, Concha Ostreae 30g, Poria cum Radix Pini 15g, Semen Ziziphi Spinosae 50g, Radix Polygalae 10g, Semen Platycladi 10g, Radix Salviae Miltiorrhizae 30g, Radix Glycyrrhizae 10g, Caulis Polygoni Multiflori 30g, Cortex Albiziae 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Radix Astragali Preparata 20g.
Embodiment 2
A Chinese medicine composition for Cure for insomnia, it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 5g, Radix Bupleuri 15g, Fructus Gardeniae 5g, Rhizoma Atractylodis Macrocephalae 15g, Os Draconis 20g, Concha Ostreae 40g, Poria cum Radix Pini 10g, Semen Ziziphi Spinosae 60g, Radix Polygalae 5g, Semen Platycladi 15g, Radix Salviae Miltiorrhizae 20g, Radix Glycyrrhizae 15g, Caulis Polygoni Multiflori 20g, Cortex Albiziae 40g, Radix Codonopsis 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 10g, Radix Astragali Preparata 30g.
Embodiment 3
A Chinese medicine composition for Cure for insomnia, it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 15g, Radix Bupleuri 5g, Fructus Gardeniae 15g, Rhizoma Atractylodis Macrocephalae 5g, Os Draconis 40g, Concha Ostreae 20g, Poria cum Radix Pini 20g, Semen Ziziphi Spinosae 40g, Radix Polygalae 15g, Semen Platycladi 5g, Radix Salviae Miltiorrhizae 40g, Radix Glycyrrhizae 5g, Caulis Polygoni Multiflori 40g, Cortex Albiziae 20g, Radix Codonopsis 20g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 20g, Radix Astragali Preparata 10g.
Embodiment 4
A Chinese medicine composition for Cure for insomnia, it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 8g, Radix Bupleuri 13g, Fructus Gardeniae 8g, Rhizoma Atractylodis Macrocephalae 13g, Os Draconis 205g, Concha Ostreae 35g, Poria cum Radix Pini 12g, Semen Ziziphi Spinosae 55g, Radix Polygalae 6g, Semen Platycladi 13g, Radix Salviae Miltiorrhizae 25g, Radix Glycyrrhizae 13g, Caulis Polygoni Multiflori 25g, Cortex Albiziae 35g, Radix Codonopsis 12g, Radix Angelicae Sinensis 18g, Radix Paeoniae Alba 12g, Radix Astragali Preparata 25g.
Embodiment 5
A Chinese medicine composition for Cure for insomnia, it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 13g, Radix Bupleuri 6g, Fructus Gardeniae 13g, Rhizoma Atractylodis Macrocephalae 6g, Os Draconis 35g, Concha Ostreae 25g, Poria cum Radix Pini 18g, Semen Ziziphi Spinosae 45g, Radix Polygalae 13g, Semen Platycladi 7g, Radix Salviae Miltiorrhizae 35g, Radix Glycyrrhizae 7g, Caulis Polygoni Multiflori 35g, Cortex Albiziae 25g, Radix Codonopsis 18g, Radix Angelicae Sinensis 12g, Radix Paeoniae Alba 18g, Radix Astragali Preparata 15g.
Chinese medicine composition in embodiment of the present invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, add cold water and cover powder, soak 15~20 minutes, then add water and do not have approximately 8 centimetres of powder, decoct.At a simmer, adopt intense fire to decoct, after boiling, use slow fire boiling 20~30 minutes; Second decocts, and after water boils, decocts 15~20 minutes.Twice decoction extracting juice that removes slag, merges.
A Chinese medicine composition for Cure for insomnia, clinical efficacy is summed up:
One, general data: this Chinese medicine composition is applied to clinical observation case 67 examples, wherein male 31 examples, female's 36 examples, 17~70 years old age.In the course of disease 2 week of the shortest person, elder reaches 2 years, average 1 year.
Two, diagnostic criteria:
1, slight: accidental, little to Quality of Life;
2, moderate: occur every night, moderate influence quality of life, accompany certain symptom (irritability, anxiety, tired etc.);
3, severe: occur every night, have a strong impact on quality of life, clinical symptoms is had outstanding performance.
Three, usage and dosage: when clinical practice, component, consumption in compositions are taken the circumstances into consideration increase and decrease according to patient's body weight, age and symptom.Within five days, be a course for the treatment of, one day potion, the about 300ml of twice extracting juice of decocting, point early, late twice half an hour ante cibum warm taking.Period in a medicine avoids eating anything raw or cold, pungent, stimulate and rotten thing.
Four, criterion of therapeutical effect:
1, clinical recovery: sleep is normal, the length of one's sleep, more than 6 hours simultaneous phenomenon disappeared;
2,effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improves;
3,invalid: before sleeping as taking medicine, or extend less than the length of one's sleep 2 hours, symptom is without improvement.
Five, therapeutic effect: in this clinical observation case, take medicine 1-6 the course for the treatment of, clinical recovery 55 examples, effective 9 examples, invalid 3 examples.During treatment, there is not toxic and side effects.
Six, model case:
Case 1:
In certain, female, 30 years old, the length of one's sleep, less than 4 hours every night, slept shallow, to sound sensitive, after waking up midnight, cannot again fall asleep, and getting up early lassitude, continues half wheat harvesting period.Take 2 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, be increased to 5 hours the length of one's sleep; Continue to strengthen 2 courses for the treatment of, ensure every day to sleep more than 6 hours, follow other transference cures.
Case 2:
Lee, man, 23 years old, large four prepared for the postgraduate qualifying examination, and early to rise and late to bed, and simple and easy the waking up of sleeping, is easily waken up with a start dreaminess, hypomnesis.Take 1 course for the treatment of of medicament prepared by Chinese medicine composition of the present invention, sleep deepens, weak fainthearted transference cure after wakeing up; Continue to take 2 courses for the treatment of, sleep normally reaches more than 6 hours, and memory is recovered.

Claims (1)

1. a Chinese medicine composition for Cure for insomnia, is characterized in that: it is to be made up of the raw material of Chinese medicine of following weight proportion: Cortex Moutan 10g, Radix Bupleuri 10g, Fructus Gardeniae 10g, Rhizoma Atractylodis Macrocephalae 10g, Os Draconis 30g, Concha Ostreae 30g, Poria cum Radix Pini 15g, Semen Ziziphi Spinosae 50g, Radix Polygalae 10g, Semen Platycladi 10g, Radix Salviae Miltiorrhizae 30g, Radix Glycyrrhizae 10g, Caulis Polygoni Multiflori 30g, Cortex Albiziae 30g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Radix Astragali Preparata 20g.
CN201310093131.4A 2013-03-22 2013-03-22 Chinese medicinal composition for treating insomnia Expired - Fee Related CN103211892B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310093131.4A CN103211892B (en) 2013-03-22 2013-03-22 Chinese medicinal composition for treating insomnia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310093131.4A CN103211892B (en) 2013-03-22 2013-03-22 Chinese medicinal composition for treating insomnia

Publications (2)

Publication Number Publication Date
CN103211892A CN103211892A (en) 2013-07-24
CN103211892B true CN103211892B (en) 2014-07-23

Family

ID=48810278

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310093131.4A Expired - Fee Related CN103211892B (en) 2013-03-22 2013-03-22 Chinese medicinal composition for treating insomnia

Country Status (1)

Country Link
CN (1) CN103211892B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103610978B (en) * 2013-12-05 2015-08-26 侯青兰 Medicine of a kind of Cure for insomnia and preparation method thereof

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311164A (en) * 2014-08-08 2016-02-10 赵国贤 Decoction for treating insomnia
CN104383460A (en) * 2014-12-09 2015-03-04 王淑廷 Traditional Chinese medicine powder for treating insomnia
CN104721649A (en) * 2015-04-15 2015-06-24 邵明冉 Traditional Chinese medicine for treating endocrine dyscrasia
CN104997923A (en) * 2015-08-10 2015-10-28 青岛琴诚医药技术有限公司 Medicinal preparation used for treating insomnia
CN105412292A (en) * 2015-12-15 2016-03-23 赵国贤 Quick-acting hypnotic soup
CN105963505A (en) * 2016-05-05 2016-09-28 刘秀梅 Traditional Chinese medicinal foot bath powder capable of treating insomnia
CN106360166A (en) * 2016-08-25 2017-02-01 安徽瑞璞牡丹科技有限公司 Preparation method of spirit-quieting cortex moutan beverage
CN106492018A (en) * 2016-11-18 2017-03-15 中国人民解放军海军医学研究所 A kind of Chinese medicine composition for treating insomnia and preparation method thereof
CN106511518A (en) * 2016-11-30 2017-03-22 上海市浦东新区肺科医院 Traditional Chinese medicine composition with effects of soothing nerves and aiding sleep
CN110201056A (en) * 2019-07-02 2019-09-06 深圳市宝安中医院(集团) A kind of Chinese medicine composition and its preparation, preparation method and application
CN111529636A (en) * 2020-06-12 2020-08-14 川北医学院附属医院 Traditional Chinese medicine composition for treating chronic insomnia, traditional Chinese medicine preparation and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954039A (en) * 2010-05-07 2011-01-26 成都海旺科技有限责任公司 Traditional Chinese medicinal decoction for treating insomnia
CN102370883A (en) * 2011-10-10 2012-03-14 邓华伦 Chinese herbal medicine for treating insufficient heart blood and restless mind

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954039A (en) * 2010-05-07 2011-01-26 成都海旺科技有限责任公司 Traditional Chinese medicinal decoction for treating insomnia
CN102370883A (en) * 2011-10-10 2012-03-14 邓华伦 Chinese herbal medicine for treating insufficient heart blood and restless mind

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103610978B (en) * 2013-12-05 2015-08-26 侯青兰 Medicine of a kind of Cure for insomnia and preparation method thereof

Also Published As

Publication number Publication date
CN103211892A (en) 2013-07-24

Similar Documents

Publication Publication Date Title
CN103211892B (en) Chinese medicinal composition for treating insomnia
CN103463404B (en) Traditional Chinese medicine composition for treating liver and kidney yin deficiency
CN103341004B (en) Chinese medicine composition for treating delayed menstrual cycle
CN103393879B (en) Traditional Chinese medicine composition for treating liver and kidney deficiency
CN103349753B (en) Traditional Chinese medicine composition for treating kidney deficiency
CN103007190B (en) Traditional Chinese medicine composition for treating insomnia
CN102988672B (en) Traditional Chinese medicine composition for treating irregular menstruation
CN103550495B (en) A kind of Chinese medicine composition of Cure for insomnia
CN103007169B (en) Traditional Chinese medicine composition for treating insomnia
CN104771606A (en) Traditional Chinese medicine composition for treating insomnia
CN103550687B (en) A kind of Chinese medicine composition for the treatment of the hepatic and renal YIN deficiency
CN104043087A (en) Traditional Chinese medicine composition for treating Raynaud syndrome
CN103211962B (en) Chinese medicinal composition for treating anhypnia
CN103007077B (en) Chinese medicinal composition for treating climacteric syndrome
CN104623362A (en) Traditional Chinese medicine composition for treating depression
CN103550531A (en) Traditional Chinese medicine composition for treating kidney qi deficiency syndrome
CN104623536A (en) Chinese medicinal combination for treating insomnia
CN104606514A (en) Traditional Chinese medicine composition for treating kidney deficiency type tinnitus
CN103550533B (en) Chinese medicine composition for treating headache during menstruation
CN105749167A (en) Traditional Chinese medicine composition for treating amenorrhea
CN104758674A (en) Traditional Chinese medicine composition for treating insomnia
CN105287949A (en) Traditional Chinese medicinal composition for treating dysmenorrhea
CN104784458A (en) Traditional Chinese medicine composition for treating insomnia
CN104606650A (en) Traditional Chinese medicine composition treating insomnia
CN103816489A (en) Traditional Chinese medicine composition for treating insomnia

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140723

Termination date: 20150322

EXPY Termination of patent right or utility model