CN103202986B - Traditional Chinese medicine composition for treating weak constitution and enhancing immunity, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating weak constitution and enhancing immunity, as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating weak constitution and enhancing immunity, as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the fried rhizoma cyperi, asarum, root of three-nerved spicebush, fructus piperis longi, pogostemon cablin, radix bupleuri, schizonepeta, fructus amomi, mint, clove, fried dried tangerine, amomum kravanh, radix angelicae pubescentis, liquorice, fried ligusticum wallichii, radix trichosanthis, folia perillae acutae, gastrodia elata, radix angelicae, sandalwood, rhizoma pinellinae paeparata and radices sileris which are used as raw materials, as well as cinnabar, borneol and realgar which are used as auxiliary materials. The traditional Chinese medicine composition disclosed by the invention has an excellent curative effect on treatment of weak constitution and enhancement of the immunity.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its preparation method and application, particularly one is used for the treatment of and has a delicate constitution, and Chinese medicine composition of enhancing immunity and its preparation method and application, the invention belongs to the field of Chinese medicines.
Background technology
So-called " having a delicate constitution " abbreviation " body void ", is called in the traditional Chinese medical science---and " deficiency syndrome ".It refers to that internal organs lose, the general name of the not enough caused multiple chronic weak disease of negative and positive of qi and blood.Body void is divided into the deficiency of vital energy, blood deficiency, the deficiency of YIN, yang deficiency Four types, and in conjunction with the heart, liver, spleen, lung, kidney the five internal organs, each dirty type that has again gas, blood, yin, yang weakness, as insufficiency of lung-QI, deficiency of spleen-YANG etc." body void " common sympton has short wind, easily tired, has a dizzy spell, not in the mood to talk, sit and also very easily perspire, be afraid of to be apt to catch cold blowing very much, and after fatigue, above-mentioned various performance all can increase the weight of, and often with One's face was like wax, there is no color, eyelid, fingernail are pale, have a dizzy spell, blurred vision, eyes are dry and astringent, hair is withered, xerosis cutis, nervous, rapid heart beat, sleep poor, forgetful, the symptom such as often feel pins and needles in one's hands and feet; Women also shows as hypomenorrhea, and color is light, amenorrhea etc.
The symptom of " body void " is found in each kind of groups, comprise postoperative patient, Disease, old people and can not get greatly good youngster of having a rest etc. because of operating pressure, " body void " patient is because having a delicate constitution, the risk ratio that hypoimmunity is compared normal population trouble various diseases improves greatly, the empty patient's easy catching a cold of body, anemophobia is cold, once flu, in short time, be difficult to recovery from illness, and easily repeatedly." body void " serious harm arrives the healthy of people, and has affected people's quality of life.
Western medicine is because ingredient is single, usually only can carry out symptomatic treatment for the empty patient's of body a symptom, and the method that replants can only be taken stopgap measures and can not be effected a permanent cure, " body void " is by internal organs loss, the caused multiple chronic weak disease of negative and positive of qi and blood deficiency, need to fundamentally nurse one's health patient's body constitution, in the hope of reaching the object of effecting a permanent cure.
The present invention is based on the principle of organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, taking individualized treatment as characteristic, has proposed this kind of Chinese medicine composition for the problems of the prior art, and it has the motility of principle-method-recipe-medicines and the safety of drug effect.For its clinical symptoms multiformity, pathogenetic complexity, Chinese medicine composition of the present invention can launch treatment from many target spots, too many levels, multipath, in clinical practice, there is rapid-action, determined curative effect, patient compliance is good, can obviously improve " body void " symptom, improve patient's autoimmunity, thereby there is wide potential applicability in clinical practice.
Summary of the invention
For above-mentioned situation, technical problem to be solved by this invention is to provide a kind for the treatment of and has a delicate constitution, Chinese medicine composition of enhancing immunity and preparation method thereof.
In order to achieve the above object, the technology used in the present invention means are:
One of the present invention is used for the treatment of and has a delicate constitution, the Chinese medicine composition of enhancing immunity, it is characterized in that comprising each raw material of Chinese medicine of following weight portion: Rhizoma Cyperi (processed) 20-30 part, Herba Asari 4-8 part, Radix Linderae 20-30 part, Fructus Piperis Longi 4-8 part, Herba Pogostemonis 20-30 part, Radix Bupleuri 20-30 part, Herba Schizonepetae 20-30 part, Fructus Amomi 5-15 part, Herba Menthae 20-30 part, Flos Caryophylli 5-15 part, Pericarpium Citri Reticulatae 20-30 part processed, Fructus Amomi Rotundus 3-6 part, Radix Angelicae Pubescentis 10-15 part, Radix Glycyrrhizae 3-6 part, Rhizoma Chuanxiong (processed) 10-15 part, Radix Trichosanthis 3-6 part, Folium Perillae 15-20 part, Rhizoma Gastrodiae 10-15 part, Radix Angelicae Dahuricae 30-40 part, Lignum Santali Albi 25-35 part, Rhizoma Pinelliae Preparatum 10-20 part, Radix Saposhnikoviae 25-35 part, Cinnabaris 10-15 part, Borneolum Syntheticum 4-8 part and Realgar 4-8 part.
Wherein, preferred, described Rhizoma Cyperi (processed) prepares in accordance with the following methods: get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, stewing spending the night, puts in pot and fry to micro-yellow, and taking-up is dried, and to obtain final product;
Described Pericarpium Citri Reticulatae processed prepares in accordance with the following methods: get Pericarpium Citri Reticulatae and choose clean impurity, wash, move in rice steamer and steam to 3-4 hour, take out, be dried, to obtain final product;
Described Rhizoma Chuanxiong (processed) prepares in accordance with the following methods: get clean Rhizoma Chuanxiong wine and mix thoroughly, treat that wine is sucked, move in rice steamer, 3-4 hour is steamed in heating, takes out, and cools, and is cut into 3mm thin slice with medicine cutter, dry, to obtain final product.
In the present invention, preferably, described Chinese medicine composition comprises each raw material of Chinese medicine of following weight portion: 6 parts of 24 parts of Rhizoma Cyperi (processed), 6 parts of Herba Asaris, 24 parts of the Radixs Linderae, 6 parts of Fructus Piperis Longi, 24 parts of Herba Pogostemonis, 24 parts of Radix Bupleuri, 24 parts of Herba Schizonepetae, 9.6 parts of Fructus Amomis, 24 parts of Herba Menthaes, 9.6 parts of Flos Caryophyllis, 24 parts of Pericarpium Citri Reticulataes processed, 4.8 parts, Fructus Amomi Rotundus, 12 parts of Radix Angelicae Pubescentiss, 4.8 parts, Radix Glycyrrhizae, 12 parts of Rhizoma Chuanxiong (processed), 4.8 parts of Radix Trichosanthis, 18 parts of Folium Perillaes, 12 parts, Rhizoma Gastrodiae, 36 parts of the Radixs Angelicae Dahuricae, 28.8 parts, Lignum Santali Albi, 14.4 parts of Rhizoma Pinelliae Preparatum, 30 parts of Radix Saposhnikoviaes, 12 parts, Cinnabaris, 6 parts of Borneolum Syntheticums and Realgars.
Further, the invention allows for a kind of method of preparing the Chinese medicine composition described in above any one, it is characterized in that being prepared in accordance with the following methods by the raw material of Chinese medicine of weight portion described in above any one:
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly or be ground into fine powder, Borneolum Syntheticum porphyrize, all the other 22 taste raw material of Chinese medicine are concocted by Chinese medicine processing method, and the raw material of Chinese medicine after the process of preparing Chinese medicine is ground into respectively coarse powder through Chinese medicine crusher;
Wherein, preferred, described Rhizoma Cyperi (processed) prepares in accordance with the following methods: get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, stewing spending the night, puts in pot and fry to micro-yellow, and taking-up is dried, and to obtain final product;
Described Pericarpium Citri Reticulatae processed prepares in accordance with the following methods: get Pericarpium Citri Reticulatae and choose clean impurity, wash, move in rice steamer and steam to 3-4 hour, take out, be dried, to obtain final product;
Described Rhizoma Chuanxiong (processed) prepares in accordance with the following methods: get clean Rhizoma Chuanxiong wine and mix thoroughly, treat that wine is sucked, move in rice steamer, 3-4 hour is steamed in heating, takes out, and cools, and is cut into 3mm thin slice with medicine cutter, dry, to obtain final product.
All the other raw material of Chinese medicine can be concocted according to conventional Chinese medicine processing method.
(2) drying and crushing: the each 22 taste Chinese medicine coarse powder after coarse crushing are dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of each 22 taste Chinese medicine by described weight portion; after getting Borneolum Syntheticum weight 2-3 mixed former medicated powder doubly and tentatively mixing with the Borneolum Syntheticum of described weight portion; pulverize; 100 mesh sieves; the fine powder after sieving adds the Realgar powder of described weight portion and Cinnabaris to be mixed together evenly, 100 mesh sieves;
(5) always mixed: former medicated powder to be added in batches in the ice bloom preparing, the amount that at every turn adds former medicated powder is the equivalent in mixer, finally the former medicated powder of not enough equivalent is all added, after adding, in mixer, mix 30 minutes at every turn, require medicated powder all by 80 mesh sieves, and containing being no less than by 100 mesh sieves 98% powder; Moisture is no more than 7.0%;
(6) powder step (5) being obtained adds the adjuvant of pharmaceutically accepting to make suitable clinically various preparations according to pharmaceutical preparation conventional method.
The inventive method can guarantee that mineral medical material, proportion fully mixs homogeneously than energy such as excessive or too small medical material, toxicity medical materials with general medical material.
In the present invention, preferred, described adjuvant be Mel, sucrose, starch, dextrin, Pulvis Talci, magnesium stearate or calcium sulfate wherein at least one.
In the present invention, preferred, described preparation is pill, capsule, granule or tablet.
Further, the invention allows for the method that Chinese medicine composition of the present invention is prepared into medicine pill, it is characterized in that being prepared in accordance with the following methods by the raw material of Chinese medicine of weight portion described in above any one:
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly or be ground into fine powder, Borneolum Syntheticum porphyrize, all the other 22 taste raw material of Chinese medicine are concocted by Chinese medicine processing method, and the raw material of Chinese medicine after the process of preparing Chinese medicine is ground into respectively coarse powder through Chinese medicine crusher;
(2) drying and crushing: the each 22 taste Chinese medicine coarse powder after coarse crushing are dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of each 22 taste Chinese medicine by described weight portion; after getting Borneolum Syntheticum weight 2-3 mixed former medicated powder doubly and tentatively mixing with the Borneolum Syntheticum of described weight portion; pulverize; 100 mesh sieves; the fine powder after sieving adds the Realgar powder of described weight portion and water Cinnabaris to be mixed together evenly, 100 mesh sieves;
(5) always mixed: former medicated powder to be added in batches in the ice bloom preparing, the amount that at every turn adds former medicated powder is the equivalent in mixer, finally the former medicated powder of not enough equivalent is all added, after adding, in mixer, mix 30 minutes at every turn, require medicated powder all by 80 mesh sieves, and containing being no less than by 100 mesh sieves 98% powder; Moisture is no more than 7.0%;
(6) refined honey: take Mel and put sealing and be in the refined honey tank of vacuum state, heating is tempered, and frequently stirs, slowly heat up, be heated to 90 DEG C, when being smelt relative density and being 1.36-1.38, stop heating, at this moment twist with the fingers honey with hands and have larger viscosity, when two fingers leave, shorter silk occurs, is smelt the Mel between middle honey and old honey, water content 8-10%, for subsequent use;
(7) close and stick together: by the Mel having refined and medicated powder by medicated powder: refined honey weight ratio=1:1.35-1.55, be preferably 1:1.45 and be equipped with, add in trough type mixing machine and mix 15 minutes, cannot see obvious medicated powder as Huaihe River, make " medicine sticks together ", pour in clean utensil cooling;
(8) pill: medicine is sticked together and added uniformly in the feeding chamber of pellet processing machine, make the ball bar of even thickness, be cut into pill through pill-making knife, by 2.5g/ ball pill, to obtain final product.
Further again, the invention allows for described Chinese medicine composition and have a delicate constitution in preparation treatment, the application in enhancing immunity medicine.And described medicine pill is treated and is had a delicate constitution in preparation, the application in enhancing immunity medicine.
In the present invention, described having a delicate constitution comprises short wind, easily tired, has a dizzy spell, not in the mood to talk, sit and also very easily perspire, be afraid of very much blowing, be apt to catch cold, One's face was like wax, there is no color, and eyelid, fingernail are pale, have a dizzy spell, blurred vision, eyes are dry and astringent, hair is withered, xerosis cutis, nervous, rapid heart beat, sleep poor, forgetful, the symptom such as often feel pins and needles in one's hands and feet; Women also shows as hypomenorrhea, and color is light, amenorrhea etc.And after fatigue, above-mentioned various performances all can increase the weight of.
Chinese medicine composition of the present invention based on the traditional Chinese medical science to having a delicate constitution, research and the Therapeutic Principle thereof of the disease pathogenesis such as hypoimmunity, simultaneously according to pharmaceutical research achievement, filter out the natural plant of blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, expelling wind and cold, according to theory of Chinese medical science prescription, be prepared from according to certain weight proportion.
The present invention is based on the principle of organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, taking individualized treatment as characteristic, has proposed this kind of Chinese medicine composition for the problems of the prior art, and it has the motility of principle-method-recipe-medicines and the safety of drug effect.For its clinical symptoms multiformity, pathogenetic complexity, Chinese medicine composition of the present invention can launch treatment from many target spots, too many levels, multipath, in clinical practice, there is rapid-action, determined curative effect, patient compliance is good, can obviously improve " body void " symptom, improve patient's autoimmunity, there is wide potential applicability in clinical practice.
Detailed description of the invention
Below by pharmacological and clinical observation experiment and the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiment, only for the object of illustration, never limit the scope of the invention.
The process of preparing Chinese medicine of each raw material of Chinese medicine and drug effect:
Rhizoma Cyperi (processed): be the dry rhizome of sedge dried tuber Cyperus rotundus L..Concoct: get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, stewing spending the night, puts in pot and fry to micro-yellow, and taking-up is dried.(100 jin of every Rhizoma Cyperi grains, with 20 jin of vinegar).Cure mainly: dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
Herba Asari (Herba Asari (drawing); Manchurian wildginger): be dry root and the rhizome of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt var.mandshuricum (Maxim.) Kitag., Seoul Herba Asari Asarum sieboldii Miq.var.seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..Concoct: remove impurity, spray clear water, slightly profit, cutting, dries in the shade.Cure mainly: the cold expelling that induces sweat, wind-expelling pain-stopping, sensible warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
The Radix Linderae (Radix Linderae (drawing); Combined spicebush root): be the dried root of canella Radix Linderae Lindera aggregata (Sims) Kosterm..Concoct: not section person, remove radicula, size separately, is soaked into, and shave is dry.Cure mainly: promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.For QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.
Fructus Piperis Longi (Fructus Piperis Longi (drawing); Long pepper): be dry near maturation or the mature fruit cluster of Piperaceae plant Fructus Piperis Longi Piper longum L..Concoct: remove impurity.Used time smashs to pieces.Cure mainly: warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, QI stagnated by cold, obstruction of qi in the chest and cardialgia, headache, toothache.
Herba Pogostemonis (Herba Pogostemonis (drawing); Cablin patchouli herb): be the dry aerial parts of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth..Concoct: remove undesirable root and impurity, first tremble inferior lobe, well sifted is separately put; Stem is cleaned, and runs through, and cutting, dries, then mixes with leaf.Cure mainly: eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, heat-damp in summer exterior syndrome, hygropyrexia is from the beginning of, heating asthenia, uncomfortable in chestly do not relax, and cold-damp is closed summer-heat; Stomachache is vomited and diarrhoea, nasosinusitis headache.
Borneolum Syntheticum (Dry obalanopsaromaticaGwaertn.f): for the fresh leaf of Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb is through the crystallization of steam distillation, cooling gained.Cure mainly: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.For calentura coma, convulsions, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Radix Bupleuri (Root of Chnese Thorowax): be the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.Concoct: remove impurity and residual stem, clean, run through, cut sheet, dry.Cure mainly: evacuate and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Realgar: (Realgar): be sulfide-based mineral Realgar family Realgar, main containing realgar (As
2s
2).Concoct: Realgar powder: get Realgar, add water and be total in right amount porphyrize, then add the water of volume, stir, incline and suspension, the part of sinking is pressed and stopped method repeatable operation for several times, makes decontamination, merges suspension, after leaving standstill, divides and gets precipitation, dries.Cure mainly: removing toxic substances parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.For carbuncle furuncle, snake bite and insect sting, abdominal pain due to worm stagnation, infantile convulsion, malaria.
Herba Schizonepetae (FineleafSchizonepetaHerb): be the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Concoct: remove impurity, spray clear water, cleans, run through, in 50 DEG C of bakings 1 hour, cutting, dry.Cure mainly: the loose wind that induces sweat, rash, skin ulcer disappears.For flu, headache, measles, rubella, skin infection from the beginning of.
Fructus Amomi (Fructus Amomi): be the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour.var.xanthioides T.L.Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T.L.Wu.Concoct: remove impurity.Used time smashs to pieces.Cure mainly: removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Herba Menthae: (Mentha haplocalyx): be the dry aerial parts of labiate Herba Menthae Mentha haplocalyx Briq..Concoct: remove old stem and impurity, slightly spray clear water, slightly profit, the section of prescinding, cold drying in time.Cure mainly: dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Flos Caryophylli (Syzygium aromaticum): be the dry flower of plant clove of myrtaceae Eugenia caryophyllata Thunb..Concoct: remove impurity, sieve dedust bits.Used time smashs to pieces.Cure mainly: warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus vomiting, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Pericarpium Citri Reticulatae processed: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Concoct: get Pericarpium Citri Reticulatae and choose clean impurity, wash, move in rice steamer and steam to 3-4 hour, take out, be dried.Cure mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Fructus Amomi Rotundus (Alpinia katsumada Hayat[Languas katsumadai (Hayata) Merr.): be the dry mature fruit of zingiberaceous plant Fructus Amomi Rotundus Amomum kravanh Pierre ex Gagnep. or amomum compactum Soland ex Maton Amomum compactum Soland ex Maton.Concoct: remove impurity.Used time smashs to pieces.Cure mainly: removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Radix Angelicae Pubescentis (Heracleumhemsleyanum): be the dry root of samphire Angelica pubescens Angelica pubescens Maxim.f.biserrata Shan et Yuan.Concoct: remove impurity, clean, run through, shave, dries or cold drying.Cure mainly: expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, wind and cold is held wet headache under the arm.
Radix Glycyrrhizae (Radix Glycyrrhizae (drawing); Liquorice root): be dry root and the rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Concoct: remove impurity, clean, run through, cut sheet, dry.Cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Rhizoma Chuanxiong (processed) (Rhizoma Ligustici Chuanxiong (drawing); Sichuan lovage rhizome): be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Concoct: get clean Rhizoma Chuanxiong wine and mix thoroughly, treat that wine is sucked, move in rice steamer, 3-4 hour is steamed in heating, takes out, cool, be cut into 3mm thin slice with medicine cutter, dry.Cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For obstruction of qi in the chest and cardialgia, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, headache, rheumatic arthralgia.
Radix Trichosanthis (Radix Trichosanthis (drawing); Snakegourd root): be the dry root of cucurbitaceous plant Fructus Trichosanthis Trichosanthes Kirilowii Maxim. or trichosanthes rosthornii Harms Trichosanthes rosthornii Harms.Concoct: slightly bubble, run through, cut sheet, dry.Cure mainly: clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Cinnabaris (CINNABARIS): be sulfide-based mineral cinnabar family cinnabar, main Containing Sulfur hydrargyrum (HgS).Concoct: cinnabar powder: get Cinnabaris, suck iron filings with Magnet, or get clean Cinnabaris, appropriate porphyrize altogether adds water.Add the water of volume again, stir, incline and suspension, sinking is partly again by upper method, and repeatable operation several, removes impurity, merges suspension, standing, divides and gets precipitation, dries or 40 DEG C of following being dried.Cure mainly: clear away heart-fire relieving convulsion, calm the nerves, improving eyesight, removing toxic substances.For palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy is gone mad, infantile convulsion, blurring of vision, aphtha, sore throat, sore swollen toxin.
Folium Perillae: (Folium Perillae (drawing); Perilla leaf) be the dried leaves (or band twig) of labiate Folium Perillae Perilla frutescens (L.) Britt..Concoct: remove impurity and old stalk; Or spray clear water, chopping, dry.Cure mainly: the cold expelling that induces sweat, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
Rhizoma Gastrodiae (Rhizoma Gastrodiae (drawing); Tall gastrodia tuber): be the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Concoct: clean, run through or steam soft, shave, dry.Cure mainly: endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.For infantile convulsion, epilepsy clonus, tetanus, has a headache dizzy, hands and feet caused by paralysis, numb limbs and tense tendons, rheumatic arthralgia.
The Radix Angelicae Dahuricae (Radix Angelicae Dahuricae (drawing); Dahurian angelica root): be the dry root of plant Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) the Benth.et Hook.f. of umbellate form section or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan.Concoct: remove impurity, size separately, is slightly soaked, and runs through, and cuts sheet, dry.Cure mainly: the cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Lignum Santali Albi (Lignum Santali Albi (drawing); Sandalwood): be the dry duramen of Santalaceae plant Lignum Santali Albi Santalum album L. trunk.Concoct: remove impurity, pound sheet or be sawn into segment, is split into fine grained chippings.Cure mainly: circulation of qi promoting warming middle-JIAO, appetizing pain relieving.For QI stagnated by cold, chest and diaphragm does not relax, obstruction of qi in the chest and cardialgia, epigastric pain, vomiting lack of appetite
Rhizoma Pinelliae Preparatum (Rhizoma Pinelliae Preparatum (drawing); Processed pinellia tuber): be the Preparation process product of the Rhizoma Pinelliae.Concoct: get the clean Rhizoma Pinelliae, size separately, is soaked in water to interior without the dry heart, takes out; Another extracting liquorice is appropriate, decocts with water secondary, collecting decoction, pour in the lime liquor of making by suitable quantity of water, stir evenly, add the above-mentioned Rhizoma Pinelliae having soaked into, soak, stir 1～2 every day, and keep immersion pH value more than 12, evenly yellow to section, mouth is tasted micro-while having numb feeling in the tongue, takes out, and cleans, dry in the shade or dry, to obtain final product.The clean Rhizoma Pinelliae of every 100kg, with Radix Glycyrrhizae 15kg, quicklime 10kg.Cure mainly: drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Radix Saposhnikoviae (Radix Saposhnikoviae (drawing); Divaricate saposhnikovia root): be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Concoct: remove impurity, clean, run through, cut sheet, dry.Cure mainly: expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
The preparation of embodiment 1, medicine pill
1, the process of preparing Chinese medicine of raw material of Chinese medicine
Raw material of Chinese medicine medicine is all bought and is obtained by market, and concocts according to the above method.
2, method
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly into fine powder, Borneolum Syntheticum porphyrize, all the other each 22 taste raw material of Chinese medicine are ground into respectively coarse powder through Chinese medicine crusher after concocting by above-mentioned Chinese medicine processing method;
(2) drying and crushing: the each 22 taste Chinese medicine coarse powder after coarse crushing are dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of each 22 taste Chinese medicine by the following stated weight, after getting former medicated powder 16kg and tentatively mixing with Borneolum Syntheticum 6kg, pulverize, cross 100 mesh sieves, fine powder after sieving adds Realgar powder 6kg, water Cinnabaris 12kg to be mixed together evenly, crosses 100 mesh sieves;
Rhizoma Cyperi (processed) 24kg, Herba Asari 6kg, Radix Linderae 24kg, Fructus Piperis Longi 6kg, Herba Pogostemonis 24kg, Radix Bupleuri 24kg, Herba Schizonepetae 24kg, Fructus Amomi 9.6kg, Herba Menthae 24kg, Flos Caryophylli 9.6kg, Pericarpium Citri Reticulatae 24kg processed, Fructus Amomi Rotundus 4.8kg, Radix Angelicae Pubescentis 12kg, Radix Glycyrrhizae 4.8kg, Rhizoma Chuanxiong (processed) 12kg, Radix Trichosanthis 4.8kg, Folium Perillae 18kg, Rhizoma Gastrodiae 12kg, Radix Angelicae Dahuricae 36kg, Lignum Santali Albi 28.8kg, Rhizoma Pinelliae Preparatum 14.4kg, Radix Saposhnikoviae 30kg.
(5) always mixed: the ice bloom preparing to be added to former medicated powder 40kg, pack in mixer and mix 30 minutes; In mixer, add again former medicated powder 80kg, mix after 30 minutes, successively former medicated powder is added in batches in the ice bloom preparing, the amount that at every turn adds former medicated powder is the equivalent of mixer Chinese medicine powder, after adding, in mixer, mix 30 minutes at every turn, finally the former medicated powder of remaining not enough equivalent is all added in mixer, remix 30 minutes.Require the medicated powder can be all by 80 mesh sieves, and contain and can pass through the powder of 100 mesh sieves many 98%; Color and luster evenly, without decorative pattern, mottle; Moisture must not cross 7.0%, after matter pipe person acceptance(check), and warehouse entry, sealing, for subsequent use.
(6) refined honey: take Mel and put sealing and be in the refined honey tank of vacuum state, heating is tempered, and frequently stirs, slowly heat up, decompression is heated to 90 DEG C, when being smelt relative density and being 1.36-1.38, stops heating, at this moment twist with the fingers honey with hands and have larger viscosity, when two fingers leave, shorter silk occurs, is smelt the Mel between middle honey and old honey, water content 8-10%, for subsequent use;
(7) close and stick together: by the Mel having refined and medicated powder by medicated powder: refined honey weight ratio=1:1.45 is equipped with, and adds in trough type mixing machine and mixes 15 minutes, cannot see obvious medicated powder as Huaihe River, makes " medicine sticks together ", pours in clean utensil cooling;
(8) pill: medicine is sticked together and added uniformly in the feeding chamber of pellet processing machine, make the ball bar of even thickness, be cut into pill through pill-making knife, by 2.5g/ ball pill, to obtain final product.
3, differentiate
(1) get this product, put micro-Microscopic observation: the brown or rufous of endotesta cytoflav, surface is seen and is class polygon, and wall is thicker, and cell includes siliceous.Secretory cell is similar round or circle, diameter 35～72 μ m, and containing yellowish-brown or brownish red thing, around it, 7-8 cell made radial circular row.Prism of calcium oxalate is present in mesocarp parenchyma in flakes.Fibre bundle around parenchyma cell, containing prism of calcium oxalate, forms crystalline cellulose.
(2) get this product 2g, the 10ml that adds diethyl ether, jolting 2 minutes, divides and gets ether layer, waves most ether, and residue adds 1% vanillin sulfuric acid solution 2-3 and drips, i.e. displaing amaranth, color burn after placing.
4, check
Moisture, weight and microorganism to medicine pill of the present invention detect, and its result is as shown in table 1 below:
Table 1
The preparation of embodiment 2, Chinese medicine water-honeyed pill
1, the process of preparing Chinese medicine of raw material of Chinese medicine (Chinese medicine processing process is with embodiment 1)
2, method
Step (1) to (6) is with embodiment 1
(7) pill: get appropriate medicated powder and pour in rustless steel seed-coating machine, water honey solution (refined honey: water=1:2.5) is made little pharmacopoeia; Rotate rustless steel seed-coating machine, water honey solution (refined honey: water=1:2.5) squirts, and then adds the general ball of former powder, so repeated multiple times, progressively increasing, solid, rounding, sieve and remove excessive, too small pill, sift out qualified wet ball, so repeatedly, until the general ball of medicated powder is complete.
(8) dry: piller to be added to horizontal boiling drier and be dried; Dried pill color and luster is even.
(9) polishing: dried dry ball is poured in rustless steel coating, and started rustless steel seed-coating machine, make pill surface rounding light, color and luster is consistent.
(10) packaging: by every bag of 1.6g specification packaging, to obtain final product.
3, differentiate
(1) get this product, put micro-Microscopic observation: the brown or rufous of endotesta cytoflav, surface is seen and is class polygon, and wall is thicker, and cell includes siliceous.Secretory cell is similar round or circle, diameter 35～72 μ m, and containing yellowish-brown or brownish red thing, around it, 7-8 cell made radial circular row.Prism of calcium oxalate is present in mesocarp parenchyma in flakes.Fibre bundle around parenchyma cell, containing prism of calcium oxalate, forms crystalline cellulose.
(2) get this product 2g, the 10ml that adds diethyl ether, jolting 2 minutes, divides and gets ether layer, waves most ether, and residue adds 1% vanillin sulfuric acid solution 2-3 and drips, i.e. displaing amaranth, color burn after placing.
4, check
Moisture, weight and microorganism to medicine pill of the present invention detect, and its result is as shown in table 2 below:
Table 2
The preparation of embodiment 3, medicine pill
Rhizoma Cyperi (processed) 30kg, Herba Asari 8kg, Radix Linderae 20kg, Fructus Piperis Longi 8kg, Herba Pogostemonis 30kg, Radix Bupleuri 20kg, Herba Schizonepetae 30kg, Fructus Amomi 15kg, Herba Menthae 30kg, Flos Caryophylli 5kg, Pericarpium Citri Reticulatae 20kg processed, Fructus Amomi Rotundus 3kg, Radix Angelicae Pubescentis 10kg, Radix Glycyrrhizae 6kg, Rhizoma Chuanxiong (processed) 15kg, Radix Trichosanthis 3kg, Folium Perillae 20kg, Rhizoma Gastrodiae 15kg, Radix Angelicae Dahuricae 30kg, Lignum Santali Albi 25kg, Rhizoma Pinelliae Preparatum 20kg, Radix Saposhnikoviae 35kg, Cinnabaris 15kg, Borneolum Syntheticum 4kg, Realgar 4kg.
Other preparation process are with embodiment 1.
The preparation of embodiment 4, tablet
The preparation of tablet is specifically carried out according to following steps:
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly or be ground into fine powder, Borneolum Syntheticum porphyrize, all the other each 22 taste raw material of Chinese medicine are concocted by above-mentioned Chinese medicine processing method;
(2) drying and crushing: the coarse powder after Rhizoma Cyperi (processed), Herba Pogostemonis, Lignum Santali Albi, this four Chinese medicine material coarse crushing of Flos Caryophylli is dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of four taste Chinese medicine by described weight, after the mixed former medicated powder that takes a morsel tentatively mixes with the Borneolum Syntheticum of described weight, pulverize, cross 100 mesh sieves, fine powder after sieving adds the Realgar powder of described weight and Cinnabaris to be mixed together evenly, crosses 100 mesh sieves;
Rhizoma Cyperi (processed) 20kg, Herba Asari 4kg, Radix Linderae 30kg, Fructus Piperis Longi 4kg, Herba Pogostemonis 20kg, Radix Bupleuri 30kg, Herba Schizonepetae 20kg, Fructus Amomi 5kg, Herba Menthae 20kg, Flos Caryophylli 15kg, Pericarpium Citri Reticulatae 30kg processed, Fructus Amomi Rotundus 6kg, Radix Angelicae Pubescentis 15kg, Radix Glycyrrhizae 3kg, Rhizoma Chuanxiong (processed) 10kg, Radix Trichosanthis 6kg, Folium Perillae 15kg, Rhizoma Gastrodiae 10kg, Radix Angelicae Dahuricae 40kg, Lignum Santali Albi 35kg, Rhizoma Pinelliae Preparatum 10kg, Radix Saposhnikoviae 25kg, Cinnabaris 10kg, Borneolum Syntheticum 8kg, Realgar 8kg.
(5) extract, concentrated, dry: all the other 18 taste Chinese medicines, in extraction pot extract, concentrated secondary is until to be condensed into relative density be the thick paste between 1.35-1.45; Thick paste is put in vacuum desiccator, is dried to dry cream at 65 DEG C.Dried cream powder is broken into can be all by 80 mesh sieves, and containing can be by 98% the dry cream fine powder of being no less than of 100 mesh sieves.
(6) always mixed: ice bloom to be packed in two-dimensional mixing machine and mixed 30 minutes with dry cream fine powder, require the medicated powder can be all by 80 mesh sieves, and contain many 98% the powder that can pass through 100 mesh sieves; Color and luster evenly, without decorative pattern, mottle; Moisture≤7.0%.
(7) granulate: approximately, in 1:0.3:0.15 ratio, make soft material in dry cream fine powder, simple syrup, 10% starch slurry, make granule of uniform size with 10 mesh sieves; Dry under 60 DEG C of conditions, dried pellet moisture answers≤9.0%.Adding 3-4% Pulvis Talci mixes and granulate;
(8) tabletting: press the heavy 0.2-0.4g tabletting of substrate, film coating, to obtain final product.
Embodiment 5, Chinese medicine composition of the present invention have a delicate constitution in treatment, the application in enhancing immunity medicine
1, clinical data
The present invention suffers to 120 examples the patient who has a delicate constitution in various degree and has carried out clinical experimental study, inclusion criteria: (1) age: 18-65 year.(2) have the Symptoms having a delicate constitution, the patient's that has a delicate constitution symptom comprises short wind, easily tired, has a dizzy spell, not in the mood to talk, sit and also very easily perspire, be afraid of very much blowing, be apt to catch cold, One's face was like wax, there is no color, and eyelid, fingernail are pale, have a dizzy spell, blurred vision, eyes are dry and astringent, hair is withered, xerosis cutis, nervous, rapid heart beat, sleep poor, forgetful, the symptom such as often feel pins and needles in one's hands and feet; Women also shows as hypomenorrhea, and color is light, amenorrhea etc.; (3) vital sign is steady.
2, Therapeutic Method
Selected patient's 100 examples, give medicine pill prepared by the embodiment of the present invention 1.
Usage: oral, 1 ball of medicine pill, 2-3 time on the one.Successive administration 6 weeks.
3, therapeutic outcome
Before treatment, 100 patients' symptom is carried out to itemized record, treat after six weeks, this 100 routine patient's symptom improvement situation is added up.Statistical result is as shown in table 3.
Criterion of therapeutical effect:
Cure: patient's symptom disappears completely, and health status is greatly improved;
Effective: patient's symptom obviously alleviates, and health status is greatly improved;
Effective: patient's symptom alleviates to some extent, but still be attended by slight having a delicate constitution;
Invalid: symptom is unchanged.
Table 3 is taken the curative effect statistics of medicine after three months
| ? | Cure | Effective | Effectively | Invalid | Total number of cases | Effective percentage |
| Statistical magnitude | 26 examples | 56 examples | 18 examples | 0 example | 100 | 100% |
During administration, patient all has no adverse reaction.
Model case
Case 1: Zhang, female, 25 years old, Distributions in Liaocheng of Shandong Province people.Operating pressure is large, often overtime work, and 2 wheat harvesting periods are front because of acute gastritis hospitalization, physical weakness after leaving hospital, do not adjust always, sensation short wind, easily tired, sometimes have a dizzy spell, speak and all do not have strength, add fatigue once, symptom is more serious, cannot go to work.Within 2012, start voluntarily to take medicine of the present invention and treat, after 6 weeks, symptom be improved significantly, in high spirits, have rosy cheeks, speak and also had strength, rocky symptom disappears completely.
Case 2: Lee, female, 30 years old, people from Ren County, Hebei province.The childbirth of 2 years causes causes massive hemorrhage, though through in many ways nourishing and produce little effect, be afraid of cold puerperal, aversion to wind, love cold perspiration always, and with soreness of the waist and knees, cold and pain in the lower abdomen, shortness of breath and palpitation, the symptoms such as limbs fatigue, Hypomenorrhea, darkish complexion, leucorrhea is many, menstrual period edema, dim complexion, long speckle.Within 2012, start voluntarily to take medicine of the present invention and treat, after 6 weeks, symptom be improved significantly, the eumenorrhea, have rosy cheeks, can participate in various outdoor activities, the psychroalgia of lower abdomen is disappearance completely.
Case 3: flood so-and-so, female, 50 years old, people from Sichuan., once the product time of catching a cold is difficult to recovery from illness very much, and easily repeatedly, often there is blurred vision in easy catching a cold, eyes are dry and astringent, and nervous, rapid heart beat, sleep poor, forgetful, the symptoms such as numbness of hands and feet; And hair is withered, xerosis cutis.Within 2012, start voluntarily to take medicine of the present invention and treat, after 6 weeks, symptom be improved significantly, the number of times that is mainly manifested in flu is obviously few, vision is not fuzzy, the situation that eyes are dry and astringent is also clearly better.The situation of nervous cardiopalmus be improved significantly, sleep quality might as well, numbness of hands and feet transference cure.
The foregoing is only the preferred embodiments of the present invention, is only illustrative for the purpose of the present invention, and nonrestrictive; Those of ordinary skill in the art understand, and in the spirit and scope that limit, can carry out many changes to it in the claims in the present invention, amendment, and even equivalence is changed, but all will fall within the scope of protection of the present invention.
Claims (10)
1. one kind is used for the treatment of and has a delicate constitution, the Chinese medicine composition of enhancing immunity, it is characterized in that being made by each raw material of Chinese medicine of following weight portion: Rhizoma Cyperi (processed) 20-30 part, Herba Asari 4-8 part, Radix Linderae 20-30 part, Fructus Piperis Longi 4-8 part, Herba Pogostemonis 20-30 part, Radix Bupleuri 20-30 part, Herba Schizonepetae 20-30 part, Fructus Amomi 5-15 part, Herba Menthae 20-30 part, Flos Caryophylli 5-15 part, Pericarpium Citri Reticulatae 20-30 part processed, Fructus Amomi Rotundus 3-6 part, Radix Angelicae Pubescentis 10-15 part, Radix Glycyrrhizae 3-6 part, Rhizoma Chuanxiong (processed) 10-15 part, Radix Trichosanthis 3-6 part, Folium Perillae 15-20 part, Rhizoma Gastrodiae 10-15 part, Radix Angelicae Dahuricae 30-40 part, Lignum Santali Albi 25-35 part, Rhizoma Pinelliae Preparatum 10-20 part, Radix Saposhnikoviae 25-35 part, Cinnabaris 10-15 part, Borneolum Syntheticum 4-8 part and Realgar 4-8 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that:
Described Rhizoma Cyperi (processed) prepares in accordance with the following methods: get clean Rhizoma Cyperi grain, mix thoroughly with vinegar, stewing spending the night, puts in pot and fry to micro-yellow, and taking-up is dried, and to obtain final product;
Described Pericarpium Citri Reticulatae processed prepares in accordance with the following methods: get Pericarpium Citri Reticulatae and choose clean impurity, wash, move in rice steamer and steam to 3-4 hour, take out, be dried, to obtain final product;
Described Rhizoma Chuanxiong (processed) prepares in accordance with the following methods: get clean Rhizoma Chuanxiong wine and mix thoroughly, treat that wine is sucked, move in rice steamer, 3-4 hour is steamed in heating, takes out, and cools, and is cut into 3mm thin slice with medicine cutter, dry, to obtain final product.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that being made up of each raw material of Chinese medicine of following weight portion: 6 parts of 24 parts of Rhizoma Cyperi (processed), 6 parts of Herba Asaris, 24 parts of the Radixs Linderae, 6 parts of Fructus Piperis Longi, 24 parts of Herba Pogostemonis, 24 parts of Radix Bupleuri, 24 parts of Herba Schizonepetae, 9.6 parts of Fructus Amomis, 24 parts of Herba Menthaes, 9.6 parts of Flos Caryophyllis, 24 parts of Pericarpium Citri Reticulataes processed, 4.8 parts, Fructus Amomi Rotundus, 12 parts of Radix Angelicae Pubescentiss, 4.8 parts, Radix Glycyrrhizae, 12 parts of Rhizoma Chuanxiong (processed), 4.8 parts of Radix Trichosanthis, 18 parts of Folium Perillaes, 12 parts, Rhizoma Gastrodiae, 36 parts of the Radixs Angelicae Dahuricae, 28.8 parts, Lignum Santali Albi, 14.4 parts of Rhizoma Pinelliae Preparatum, 30 parts of Radix Saposhnikoviaes, 12 parts, Cinnabaris, 6 parts of Borneolum Syntheticums and Realgars.
4. the method for the Chinese medicine composition described in preparation claim 1-3 any one, is characterized in that this preparation method comprises following steps:
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly or be ground into fine powder, Borneolum Syntheticum porphyrize, all the other 22 taste raw material of Chinese medicine are concocted by Chinese medicine processing method, and the raw material of Chinese medicine after the process of preparing Chinese medicine is ground into respectively coarse powder through Chinese medicine crusher;
(2) drying and crushing: the each 22 taste Chinese medicine coarse powder after coarse crushing are dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of each 22 taste Chinese medicine by described weight portion; after getting Borneolum Syntheticum weight 2-3 mixed former medicated powder doubly and tentatively mixing with the Borneolum Syntheticum of described weight portion; pulverize; 100 mesh sieves; the fine powder after sieving adds the Realgar powder of described weight portion and Cinnabaris to be mixed together evenly, 100 mesh sieves;
(5) always mixed: former medicated powder to be added in batches in the ice bloom preparing, the amount that at every turn adds former medicated powder is the equivalent of mixer Chinese medicine powder, finally the former medicated powder of not enough equivalent is all added, after adding, in mixer, mix 30 minutes at every turn, require medicated powder all by 80 mesh sieves, and containing being no less than by 100 mesh sieves 98% powder; Moisture is no more than 7.0%;
(6) powder step (5) being obtained adds the adjuvant of pharmaceutically accepting to make suitable clinically various preparations according to pharmaceutical preparation conventional method.
5. method as claimed in claim 4, it is characterized in that described adjuvant be Mel, sucrose, starch, dextrin, Pulvis Talci, magnesium stearate or calcium sulfate wherein at least one.
6. preparation method as claimed in claim 4, is characterized in that described preparation is pill, capsule, granule or tablet.
7. one kind has a delicate constitution for the preparation for the treatment of, and the method for the medicine pill of enhancing immunity is characterized in that being prepared in accordance with the following methods by the raw material of Chinese medicine of weight portion described in claim 1-3 any one:
(1) pretreatment of raw material: Cinnabaris and Realgar respectively water fly or be ground into fine powder, Borneolum Syntheticum porphyrize, all the other 22 taste raw material of Chinese medicine are concocted by Chinese medicine processing method, and the raw material of Chinese medicine after the process of preparing Chinese medicine is ground into respectively coarse powder through Chinese medicine crusher;
(2) drying and crushing: the each 22 taste Chinese medicine coarse powder after coarse crushing are dried 240 minutes with heated-air circulation oven at 60 DEG C; Being ground into respectively with Chinese medicine grinder can be all by 80 mesh sieve again, and containing the former medicated powder that can be no less than by 100 mesh sieves 98% powder;
(3) Realgar and Cinnabaris are crossed respectively 100 mesh sieves;
(4) preparation of ice bloom: mix the former medicated powder of each 22 taste Chinese medicine by described weight portion; after getting Borneolum Syntheticum weight 2-3 mixed former medicated powder doubly and tentatively mixing with the Borneolum Syntheticum of described weight portion; pulverize; 100 mesh sieves; the fine powder after sieving adds the Realgar powder of described weight portion and Cinnabaris to be mixed together evenly, 100 mesh sieves;
(5) always mixed: former medicated powder to be added in batches in the ice bloom preparing, the amount that at every turn adds former medicated powder is the equivalent of mixer Chinese medicine powder, finally the former medicated powder of not enough equivalent is all added, after adding, in mixer, mix 30 minutes at every turn, require medicated powder all by 80 mesh sieves, and containing passing through the powder of 100 mesh sieves many 98%; Moisture is no more than 7.0%;
(6) refined honey: take Mel and put sealing and be in the refined honey tank of vacuum state, heating is tempered, and frequently stirs, slowly heat up, decompression is heated to 90 DEG C, when being smelt relative density and being 1.36-1.38, stops heating, at this moment twist with the fingers honey with hands and have larger viscosity, when two fingers leave, shorter silk occurs, is smelt the Mel between middle honey and old honey, water content 8-10%, for subsequent use;
(7) close and stick together: by the Mel having refined and medicated powder by medicated powder: refined honey weight ratio=1:1.35-1.55, be preferably 1:1.45 and be equipped with, add in trough type mixing machine and mix 15 minutes, cannot see obvious medicated powder as Huaihe River, make " medicine sticks together ", pour in clean utensil cooling;
(8) pill: medicine is sticked together and added uniformly in the feeding chamber of pellet processing machine, make the ball bar of even thickness, be cut into pill through pill-making knife, by 2.5g/ ball pill, to obtain final product.
8. the medicine pill preparing in accordance with the method for claim 7.
9. the Chinese medicine composition described in claim 1-3 any one has a delicate constitution in preparation treatment, the application in enhancing immunity medicine.
10. medicine pill claimed in claim 8 has a delicate constitution in preparation treatment, the application in enhancing immunity medicine.
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| CN105194613A (en) * | 2015-10-12 | 2015-12-30 | 阿迪拉·阿布来提 | Traditional Chinese medicine composition for treating acute gastritis and preparation method of traditional Chinese medicine composition |
| CN106138977A (en) * | 2016-09-16 | 2016-11-23 | 成都市飞龙水处理技术研究所 | A kind for the treatment of has a delicate constitution and the Chinese medicine composition of enhancing immunity and preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106685A (en) * | 1994-09-28 | 1995-08-16 | 孙培义 | Sachet medicine |
| CN1695641A (en) * | 2004-05-13 | 2005-11-16 | 童玉新 | Method for preparing capsule of pure yang vital-qi |
| CN101002900A (en) * | 2007-01-05 | 2007-07-25 | 梁进 | Plaster for detumescence and drawing out poison |
| CN102349991A (en) * | 2011-05-29 | 2012-02-15 | 王红芳 | Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition |
-
2013
- 2013-04-02 CN CN201310113534.0A patent/CN103202986B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106685A (en) * | 1994-09-28 | 1995-08-16 | 孙培义 | Sachet medicine |
| CN1695641A (en) * | 2004-05-13 | 2005-11-16 | 童玉新 | Method for preparing capsule of pure yang vital-qi |
| CN101002900A (en) * | 2007-01-05 | 2007-07-25 | 梁进 | Plaster for detumescence and drawing out poison |
| CN102349991A (en) * | 2011-05-29 | 2012-02-15 | 王红芳 | Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition |
Non-Patent Citations (2)
| Title |
|---|
| 周宝宽.抗疲劳防治亚健康中药整理与研究.《中华中医药学刊》.2008,第26卷(第1期),193-195. |
| 抗疲劳防治亚健康中药整理与研究;周宝宽;《中华中医药学刊》;20080131;第26卷(第1期);193-195 * |
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Denomination of invention: The invention relates to a traditional Chinese medicine composition for treating physical weakness and enhancing immunity, and a preparation method and application thereof Effective date of registration: 20211217 Granted publication date: 20140723 Pledgee: Meizhou Rural Commercial Bank Co.,Ltd. Pledgor: GUANGDONG LIANKANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980015424 |
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