CN103191038B - Toothpaste for assisting gingivitis treatment - Google Patents
Toothpaste for assisting gingivitis treatment Download PDFInfo
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- CN103191038B CN103191038B CN201310113804.8A CN201310113804A CN103191038B CN 103191038 B CN103191038 B CN 103191038B CN 201310113804 A CN201310113804 A CN 201310113804A CN 103191038 B CN103191038 B CN 103191038B
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Abstract
The invention provides a toothpaste for assisting gingivitis treatment. The toothpaste comprises 20%-30% of traditional Chinese medicine composition extracting solution fir assisting gingivitis treatment, 2%-4% of binder, 18%-28% friction agent, 40%-50% of humectant, 1%-3% of surfactant, 1%-2% of sweetening agent, 0.5%-1.5% stabilizer, 1.5%-2.5% of antibacterial agent and the balance of water. The toothpaste can be used for effectively improving the gingival index and the plaque index and reducing the degree of gingivitis, and has very helpful effect on treating gingivitis.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of gingivitis.
Background technology
Gingivitis refers to gingiva gum edge and the hyperemia of gum nipple, the inflammatory disorders that infiltrates, oozes out, it is department of stomatology door emergency treatment commonly encountered diseases, belong to the categories such as traditional Chinese medical science toothache, gingival abscess, bleeding from the gum, gingivitis is one of modal oral diseases of the mankind, each department all over the world, each race, each age level, its prevalence is up to more than 90%, and gingivitis has become outstanding oral cavity health problem.
Gingivitis is the inflammation of gingiva tissue, taking gingival hemorrhage as principal character, generally easily hemorrhage in the time brushing teeth, suck and chew hard thing, gingiva is scarlet or aubergine, swelling or soft, surface is shinny, there are tartar, soft dirt, plaque build-up in part, the erosion of advantage gingival margin, and extruding gum edge has a small amount of pus to discharge, and can there is gum papilledema and gingival sulcus intensification, even form gingival abscess.
The pathogenic factor of most of gingivitis case is to be caused by local factor, is mainly stimulated and is caused gingival hemorrhage by bacterial plaque, calculus or the food impaction of neck portion, and edema produces gingivitis, periodontitis.The hyperemia of gingival sulcus endothelial tissue, inflammatory reaction forms granulation tissue, very easily causes angiorrhexis hemorrhage (examine as visited that method is improper, scaling is hemorrhage etc.) once be upset.The pathogenic factor of some cases is to be caused by systemic factor, as hypertension, coronary heart disease, diabetes, liver cirrhosis, blood disease.
Gingivitis is the pathological changes in advance of periodontitis, and as treatment thoroughly not in time, the inflammation of gingiva tissue may develop into periodontitis under the effect of body internal and external factor, cause the carrying out property destruction of tooth essence, finally cause odontoseisis, come off, the oral cavity to the mankind and the health hazard of whole body are very big.
Treat clinically gingivitis and adopt periodental non-surgical treatment more, coordinate whole body or topical application antibiotic and chemical synthetic drug simultaneously.Although periodental non-surgical treatment is effective to removing bacterial plaque and controlling inflammation, long-term control bacterial plaque is very difficult in desirable level.Whole body life-time service antibiotic likely causes dysbacteriosis, produce the adverse consequencess such as drug resistance, and medicine local concentration is relatively low.Although the adverse consequences that periodontal local application can avoid systemic administration likely to occur, also exists and uses inconvenience, causes multiple side effect, produces the shortcomings such as drug resistance.In addition, current various periodontal local application dosage form great majority are mainly bacteriostasis and sterilization preparation, or some biomembrane preparation only can play the effect that promotes gingiva tissue regeneration, therefore, people expect a kind of existing antiinflammatory and bacteriostatic functions, can regulate oral cavity microecological balance, have again the comparatively desirable natural drug that promotes gingiva tissue regeneration, repair.
Yuan Dynasty's Zhu Zhenheng is pointed out in " disease is controlled gingival bleeding introduction because of arteries and veins ": " gingival bleeding person, the disease of gingival hemorrhage also.Have two through other, the bright the intestines and stomach of a main sun, a main few cloudy kidney channel.If blood comes as gushes, the oncoming force is very sudden and violent, carrys out blood a lot of, and the blood of this positive bright gingival bleeding also, has diseases caused by exogenous pathogenic factor, has internal injury; If blood carrys out drop, the oncoming force is slow, carrys out blood few, and the blood of this few cloudy kidney channel also, has internal injury, without diseases caused by exogenous pathogenic factor." " treatise on blood trouble bleeding from the gum " say: " and dental bed particularly stomach through venation institute around, therefore all epistaxis are all flaming up of stomach-fire, blood is moving with fire, always method for the treatment of is taking cleaning stomach-fire as main ".The stomach channel of foot-Yang-ming is followed row and is entered gums, and excessiveness of stomach-fire, follows through upper steaming gums, and " fire of the person, only stomach is the strongest ", fire rises in gums, red swelling of gingiva, and fire is contained and is hindered oozing of blood of venation.According to motherland's theory of medicine, the morbidity of gingivitis is flourishing as main taking pathogenic fire, for the bright stomach of sun high through excess-fire or few cloudy kidney channel deficiency of YIN fire, hyperactivity of deficient fire or both have concurrently, the stomach channel of foot-Yang-ming is followed nose side and is entered upper tooth, the internal organs such as the morbidity of gingivitis and gastrointestinal, liver and gall, kidney have close relationship, and its taste are had one's ideas straightened out in mouth, and brothers' Yangming Channel arteries and veins follows row in upper and lower gingiva; Accumulate when poly-when taste, dampness-heat in the liver and gallbladder, on Chang Xunjing, disturb, cause red swelling of gingiva pain, or pyorrhea, when bleeding due to blood-heat can cause gingival hemorrhage, the diseases such as bitter taste halitosis.
The key of control gingivitis is to control bacterial plaque, brushing teeth is the Main Means of removing bacterial plaque, and toothpaste is the necessary in our daily life, adds a small amount of material can make toothpaste except having traditional function, separately have special merit in toothpaste, toothpaste can effectively reduce dental plaque to be piled up, and alleviates gingivitis degree.Toothpaste antiplaque is mainly the pharmacological action of the antiplaque medicine by adding in toothpaste, in toothpaste, add some drugs, approved at present for oral diseases such as prevention of gingivitis, Chinese herbal medicine in China source abundant, a lot of ancient prescription curative effects all very definite, toxic and side effects is obviously little than Western medicine, in the common people, also have very high acceptance, therefore adopt Chinese herbal toothpaste to prevent oral disease really to there is good prospect.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of gingivitis is provided, and adopts this Chinese medicine composition can effectively improve gingival index and plaque index, alleviates gingivitis degree, and treatment gingivitis is had to good help effect.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of gingivitis, it is characterized in that: comprise Gypsum Fibrosum, Radix Liriopes, Herba Houttuyniae, Myrrha, Semen Arecae, Fructus Crataegi, Radix Paeoniae Rubra, Folium Et Cacumen Murrayae, Radix et Rhizoma Rhei (stir-fried with wine), Rhizoma Coptidis, Radix Asparagi, Radix Achyranthis Bidentatae, Rhizoma Cimicifugae, Caulis Mahoniae, dried Alumen, Radix Panacis Quinquefolii, Cacumen Platycladi, Radix Rubiae, Herba Sarcandrae, Herba Lycopi, Folium Ilicis Cornutae, Caulis Trachelospermi, the Radix Angelicae Dahuricae, Flos Lonicerae.
Wherein, the weight portion of each component is respectively Gypsum Fibrosum 42～52 weight portions, Radix Liriopes 39～49 weight portions, Herba Houttuyniae 26～36 weight portions, Myrrha 12～22 weight portions, Semen Arecae 10～20 weight portions, Fructus Crataegi 17～27 weight portions, Radix Paeoniae Rubra 38～48 weight portions, Folium Et Cacumen Murrayae 30～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 37～47 weight portions, Rhizoma Coptidis 78～88 weight portions, Radix Asparagi 28～38 weight portions, Radix Achyranthis Bidentatae 40～50 weight portions, Rhizoma Cimicifugae 15～25 weight portions, Caulis Mahoniae 29～39 weight portions, dried Alumen 36～46 weight portions, Radix Panacis Quinquefolii 52～62 weight portions, Cacumen Platycladi 46～56 weight portions, Radix Rubiae 40～50 weight portions, Herba Sarcandrae 27～37 weight portions, Herba Lycopi's 19～29 weight portions, Folium Ilicis Cornutae 31～41 weight portions, Caulis Trachelospermi 28～38 weight portions, the Radix Angelicae Dahuricae 35～45 weight portions, Flos Lonicerae 51～61 weight portions.
Wherein, the weight portion of each component is respectively Gypsum Fibrosum 47～52 weight portions, Radix Liriopes 44～49 weight portions, Herba Houttuyniae 26～31 weight portions, Myrrha 12～17 weight portions, Semen Arecae 10～15 weight portions, Fructus Crataegi 17～22 weight portions, Radix Paeoniae Rubra 38～43 weight portions, Folium Et Cacumen Murrayae 35～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 42～47 weight portions, Rhizoma Coptidis 83～88 weight portions, Radix Asparagi 33～38 weight portions, Radix Achyranthis Bidentatae 45～50 weight portions, Rhizoma Cimicifugae 20～25 weight portions, Caulis Mahoniae 34～39 weight portions, dried Alumen 41～46 weight portions, Radix Panacis Quinquefolii 57～62 weight portions, Cacumen Platycladi 51～56 weight portions, Radix Rubiae 45～50 weight portions, Herba Sarcandrae 32～37 weight portions, Herba Lycopi's 19～24 weight portions, Folium Ilicis Cornutae 31～36 weight portions, Caulis Trachelospermi 33～38 weight portions, the Radix Angelicae Dahuricae 40～45 weight portions, Flos Lonicerae 56～61 weight portions.
Wherein, the weight portion of each component is respectively Gypsum Fibrosum 47 weight portions, Radix Liriopes 44 weight portions, Herba Houttuyniae 31 weight portions, Myrrha 17 weight portions, Semen Arecae 15 weight portions, Fructus Crataegi 22 weight portions, Radix Paeoniae Rubra 43 weight portions, Folium Et Cacumen Murrayae 35 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 47 weight portions, Rhizoma Coptidis 88 weight portions, Radix Asparagi 33 weight portions, Radix Achyranthis Bidentatae 45 weight portions, Rhizoma Cimicifugae 20 weight portions, Caulis Mahoniae 34 weight portions, dried Alumen 46 weight portions, Radix Panacis Quinquefolii 62 weight portions, Cacumen Platycladi 56 weight portions, Radix Rubiae 45 weight portions, Herba Sarcandrae 32 weight portions, Herba Lycopi's 19 weight portions, Folium Ilicis Cornutae 31 weight portions, Caulis Trachelospermi 33 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Flos Lonicerae 56 weight portions.
The preparation method of described Chinese medicine composition comprises:
The first step, by Radix Et Rhizoma Rhei stripping and slicing, the yellow wine that adds 0.1～0.2 weight portion stirs, vexed, is placed in parch container, fries 30～50 minutes with slow fire, takes out, and leaves standstill cooling, is ground into powder with pulverizer, obtains Radix et Rhizoma Rhei (stir-fried with wine);
Second step, cleans Alumen, pounds into fritter, is placed in container, is fired to when crisp, takes out, and cools, and is ground into powder with pulverizer, obtains dried Alumen;
The 3rd step, puts into frying pan by Radix Rubiae and fries into charcoal, is ground into smalls with pulverizer;
The 4th step, remaining component is sent in pulverizer and pulverized respectively, send into subsequently in blender and stir 20 minutes～40 minutes, in the ethanol that to be poured into respect to the determining alcohol of 3～5 times of its quality be 90%～95%, the Radix et Rhizoma Rhei (stir-fried with wine) powder that the first step is obtained, the dried Alumen powder that second step obtains, the Indian Madder Root that the 3rd step obtains also joins in this alcoholic solution, by alcoholic solution reflux 3～6 hours, leave standstill cooling, filter, obtain the first filtrate, in the ethanol that it is 90%～95% that filtering residue adds with respect to the determining alcohol of 3～5 times of its quality again, reflux 3～6 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain traditional Chinese medicine composition extract liquid, concentrating under reduced pressure is removed ethanol, obtain and get dry extract, pulverize, to entering in water, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml～2g/ml.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention can effectively improve gingival index and plaque index, alleviates gingivitis degree, and treatment gingivitis is had to good help effect.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition that is used for the treatment of gingivitis, comprise Gypsum Fibrosum, Radix Liriopes, Herba Houttuyniae, Myrrha, Semen Arecae, Fructus Crataegi, Radix Paeoniae Rubra, Folium Et Cacumen Murrayae, Radix et Rhizoma Rhei (stir-fried with wine), Rhizoma Coptidis, Radix Asparagi, Radix Achyranthis Bidentatae, Rhizoma Cimicifugae, Caulis Mahoniae, dried Alumen, Radix Panacis Quinquefolii, Cacumen Platycladi, Radix Rubiae, Herba Sarcandrae, Herba Lycopi, Folium Ilicis Cornutae, Caulis Trachelospermi, the Radix Angelicae Dahuricae, Flos Lonicerae.
Described Radix et Rhizoma Rhei (stir-fried with wine) is that Radix Et Rhizoma Rhei adopts wine moxibustion therapy to concoct (referring to the Pharmacopoeia of the People's Republic of China 2010 editions) that obtain.
Described dried Alumen is that Alumen forges through over-illumination (referring to the Pharmacopoeia of the People's Republic of China 2010 editions) that method obtains.
Further, described Chinese medicine composition is only made up of said components.
In described Chinese medicine composition, the weight portion of each component is respectively Gypsum Fibrosum 42～52 weight portions, Radix Liriopes 39～49 weight portions, Herba Houttuyniae 26～36 weight portions, Myrrha 12～22 weight portions, Semen Arecae 10～20 weight portions, Fructus Crataegi 17～27 weight portions, Radix Paeoniae Rubra 38～48 weight portions, Folium Et Cacumen Murrayae 30～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 37～47 weight portions, Rhizoma Coptidis 78～88 weight portions, Radix Asparagi 28～38 weight portions, Radix Achyranthis Bidentatae 40～50 weight portions, Rhizoma Cimicifugae 15～25 weight portions, Caulis Mahoniae 29～39 weight portions, dried Alumen 36～46 weight portions, Radix Panacis Quinquefolii 52～62 weight portions, Cacumen Platycladi 46～56 weight portions, Radix Rubiae 40～50 weight portions, Herba Sarcandrae 27～37 weight portions, Herba Lycopi's 19～29 weight portions, Folium Ilicis Cornutae 31～41 weight portions, Caulis Trachelospermi 28～38 weight portions, the Radix Angelicae Dahuricae 35～45 weight portions, Flos Lonicerae 51～61 weight portions.
More preferably Gypsum Fibrosum 47～52 weight portions of the weight portion of each component in described Chinese medicine composition, Radix Liriopes 44～49 weight portions, Herba Houttuyniae 26～31 weight portions, Myrrha 12～17 weight portions, Semen Arecae 10～15 weight portions, Fructus Crataegi 17～22 weight portions, Radix Paeoniae Rubra 38～43 weight portions, Folium Et Cacumen Murrayae 35～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 42～47 weight portions, Rhizoma Coptidis 83～88 weight portions, Radix Asparagi 33～38 weight portions, Radix Achyranthis Bidentatae 45～50 weight portions, Rhizoma Cimicifugae 20～25 weight portions, Caulis Mahoniae 34～39 weight portions, dried Alumen 41～46 weight portions, Radix Panacis Quinquefolii 57～62 weight portions, Cacumen Platycladi 51～56 weight portions, Radix Rubiae 45～50 weight portions, Herba Sarcandrae 32～37 weight portions, Herba Lycopi's 19～24 weight portions, Folium Ilicis Cornutae 31～36 weight portions, Caulis Trachelospermi 33～38 weight portions, the Radix Angelicae Dahuricae 40～45 weight portions, Flos Lonicerae 56～61 weight portions.
In described Chinese medicine composition, the weight portion of each component most preferably is Gypsum Fibrosum 47 weight portions, Radix Liriopes 44 weight portions, Herba Houttuyniae 31 weight portions, Myrrha 17 weight portions, Semen Arecae 15 weight portions, Fructus Crataegi 22 weight portions, Radix Paeoniae Rubra 43 weight portions, Folium Et Cacumen Murrayae 35 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 47 weight portions, Rhizoma Coptidis 88 weight portions, Radix Asparagi 33 weight portions, Radix Achyranthis Bidentatae 45 weight portions, Rhizoma Cimicifugae 20 weight portions, Caulis Mahoniae 34 weight portions, dried Alumen 46 weight portions, Radix Panacis Quinquefolii 62 weight portions, Cacumen Platycladi 56 weight portions, Radix Rubiae 45 weight portions, Herba Sarcandrae 32 weight portions, Herba Lycopi's 19 weight portions, Folium Ilicis Cornutae 31 weight portions, Caulis Trachelospermi 33 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Flos Lonicerae 56 weight portions.
In each component of Chinese medicine composition of the present invention, Gypsum Fibrosum property and flavor of peppery and cold, can rush down clearly positive bright stomach through excess-fire, Radix Liriopes yin nourishing pathogenic fire reducing, share with Gypsum Fibrosum, removing the relative excess fire clearly, can yin nourishing be fallen by asthenic fire again, Herba Houttuyniae heat-clearing and toxic substances removing, Myrrha dissipating blood stasis for subsidence of swelling, Semen Arecae killing insect and eliminating accumulation, Radix Paeoniae Rubra cool the blood dissipate blood stasis, Rhizoma Coptidis bitter cold is directly rolled over the fire of stomach internal organs, Radix Et Rhizoma Rhei purgation of spleen excess excess of the stomach fire and high Sheng fire mutually, Fructus Crataegi circulation of qi promoting dissipating blood stasis, Folium Et Cacumen Murrayae promoting flow of QI and blood dissipating blood stasis, Radix Rubiae cooling blood for hemostasis, Radix Asparagi nourishing YIN and clearing away lung-heat is promoted the production of body fluid, Radix Achyranthis Bidentatae promoting blood circulation to remove obstruction in the collateral, conducting blood to flow downwards, Rhizoma Cimicifugae heat-clearing and toxic substances removing, Caulis Mahoniae is rushed down the fire of stomach internal organs, dried Alumen hemostasisization is rotten, Radix Panacis Quinquefolii boosting qi and nourishing yin promotes the production of body fluid, Cacumen Platycladi cooling blood for hemostasis, Herba Sarcandrae clearing away heat and cooling blood, Herba Lycopi's inducing diuresis to remove edema, Folium Ilicis Cornutae clearing away heat and nourishing YIN, the detumescence of Caulis Trachelospermi removing heat from blood, Radix Angelicae Dahuricae reducing swelling and alleviating pain, Flos Lonicerae heat-clearing and toxic substances removing, all medicines share, play altogether clearing away heat-fire (excess-fire), nourishing YIN to lower pathogenic fire (asthenic fire), cooling blood for hemostasis, the effect of conducting blood to flow downwards.
In side, each component pharmacology is as follows:
Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold, enter lung, stomach warp, there is clearing away heat-fire, the quench the thirst effect of relieving restlessness, the all thin and matter weights of its abnormal smells from the patient, the excess-heat of energy removing summer-heat stomach of foot Yang Ming, filling the air for the treatment of pathogen invading YANG MING is high hot, profuse sweating, thirsty, vexed, the symptoms such as arteries and veins flood, for the key medicine of the bright stomach warp of sun, to epidemic encephalitis, encephalitis b, high heat due to pneumonia etc. has good antipyretic effect, and have relieving convulsion effect concurrently, also can be used for the burning pain in the epigastrium due to the high Sheng of stomach-fire, headache, aphtha of the mouth and tongue and heat-damp in summer dysphoria with smothery sensation, lung-heat cough with asthma, restlessness and thirst, damp and hot obstruction of meridian, the cards such as the pyretic arthralgia of arthralgia.
Radix Liriopes: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, there is heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, snakeworm is wanted first-class card, Herba Houttuyniae master is containing decanoylacetaldehyde, Osmanthus tragranscv.Aurantiacu aldehyde, methylnonanone, Bai Pili glycoside etc., and major function is reducing swelling and alleviating pain, hemostasis, antibacterial, and can enhancing human body immunity power, improve local blood circulation, reduce inflammatory exudation, promote epithelial repair.
Myrrha: bitter in the mouth, pungent, property is flat, enters liver, spleen, the heart, kidney channel, has effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cures mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Semen Arecae: bitter in the mouth, pungent, warm in nature, return stomach, large intestine channel, there is parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, effect of preventing the attack (or recurrence) of malaria, cures mainly abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, the cards such as malaria, Semen Arecae can promote gastrointestinal motility, improves the secretion of motilin and vasoactive intestinal peptide, and Semen Arecae water decoction has inhibitory action to streptococcus mutans killer cell adhesion.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, have promoting digestion and invigorating the stomach, effect of circulation of qi promoting dissipating blood stasis, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, the cards such as facilitating digestion, Fructus Crataegi can promote saliva of buccal cavity secretion, has lysozyme in saliva, and antibacterial is also had to killing action.
Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, return Liver Channel, there is removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cures mainly the conjunctival congestion and swelling pain that liver-fire is vigorous, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; The caused various pain of blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.
Folium Et Cacumen Murrayae: acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, eczema, the cards such as external treatment toothache.
Radix et Rhizoma Rhei (stir-fried with wine): bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald, Radix Et Rhizoma Rhei hemostatic mechanism is that rhatannin can be restrained wound surface and stop blooding, can lower the permeability of blood capillary and improve its fragility, reduce the outflow of wound surface body fluid, having increases platelet, makes blood clotting time shorten, promotes the effect of blood coagulation, and Radix et Rhizoma Rhei (stir-fried with wine) is for Akamu pharyngeal swelling, gingivitis, Radix Et Rhizoma Rhei is got the property of its bitter cold sedimentation, and main purgation of spleen excess excess of the stomach fire and high Sheng fire mutually can make the fiery of inflammation following let out.
Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, have effect of heat-clearing and toxic substances removing, eliminating fire and detoxication, parasite killing, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle, external treatment eczema, eczema, the auditory meatus card such as suppurate.
Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, there is nourishing YIN to relieve dryness, effect that lung heat clearing is promoted the production of body fluid, cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of not solid seminal emission, premature ejaculation and the hyperactivity of deficient fire of kidney essense, calentura Tianjin wound is thirsty, the interior-heat cards such as dryness of the intestine constipation of quenching one's thirst.
Radix Achyranthis Bidentatae: bitter in the mouth, sweet, sour, property is flat, returns liver, kidney channel, has the cards such as eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, drink blood be descending, cures mainly amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, aphtha, the cards such as haematemesis.
Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has the rash of delivering, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome is sent out speckle; Proctoptosis, the cards such as uterine prolapse.
Caulis Mahoniae: bitter in the mouth, cold in nature, return large intestine, kidney, lung meridian, there is effect of heat clearing away, dampness, removing toxic substances, cure mainly cough due to lung-heat, jaundice, has loose bowels, dysentery, conjunctival congestion and swelling pain, skin infection, eczema, the cards such as scald.
Dried Alumen: sour in the mouth, puckery, cold in nature, return lung, spleen, liver, large intestine channel, dried Alumen removing dampness sore, hemostasisization is rotten, for eczema eczema, proctoptosis, hemorrhoid, Ting discharging ear, epistaxis, the cards such as bleeding from the gum.
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, have boosting qi and nourishing yin, and effect of clearing away heat and promoting production of body fluid cures mainly the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, dryness of the mouth and throat.
Cacumen Platycladi: bitter in the mouth, puckery, cold in nature, enter the heart, liver, large intestine channel, there is cooling blood for hemostasis, wind-damp dispelling, effect of loose toxic swelling, cures mainly haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, mumps, the cards such as scald.
Radix Rubiae: cold in nature, bitter in the mouth, returns Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cures mainly: heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, the card such as metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.
Herba Sarcandrae: latin name Sarcandrae Herba, slightly warm in nature, bitter in the mouth, pungent, has anti-inflammation, dispelling wind and removing obstruction in the collateral, effect of blood circulation promoting and dispersing pathogen accumulation, cures mainly the cards such as pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor
Herba Lycopi: bitter in the mouth, pungent, slightly warm in nature, enters liver, spleen channel, has blood circulation promoting and blood stasis dispelling, line water detumescence, and the effect of removing toxicity for eliminating carbuncles, for all cards of women's multiparity congestion, as blood stasis amenorrhea, dysmenorrhea etc., also for cards such as edema, ascites, traumatic injury, too fat to move skin infection.
Folium Ilicis Cornutae: bitter in the mouth, cool in nature, return liver, kidney channel, there is effect of clearing away heat and nourishing YIN, kidney tonifying suppressing the hyperactive liver, cure mainly pulmonary tuberculosis hemoptysis, osteopyrexia and fever, the card such as have a dizzy spell.
Caulis Trachelospermi: cold nature, bitter in the mouth, has dispelling wind and removing obstruction in the collateral, and effect of removing heat from blood detumescence, cures mainly the cards such as rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, returns lung, spleen, stomach warp, has the cold expelling of inducing sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.
Flos Lonicerae: sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, there is the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and has broad-spectrum antibacterial action.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:
The first step, by Radix Et Rhizoma Rhei stripping and slicing, the yellow wine that adds 0.1～0.2 weight portion stirs, vexed, is placed in parch container, fries 30～50 minutes with slow fire, takes out, and leaves standstill cooling, is ground into powder with pulverizer, obtains Radix et Rhizoma Rhei (stir-fried with wine);
Second step, cleans Alumen, pounds into fritter, is placed in container, is fired to when crisp, takes out, and cools, and is ground into powder with pulverizer, obtains dried Alumen;
The 3rd step, puts into frying pan by Radix Rubiae and fries into charcoal, is ground into smalls with pulverizer;
The 4th step, remaining component is sent in pulverizer and pulverized respectively, send into subsequently in blender and stir 20 minutes～40 minutes, in the ethanol that to be poured into respect to the determining alcohol of 3～5 times of its quality be 90%～95%, the Radix et Rhizoma Rhei (stir-fried with wine) powder that the first step is obtained, the dried Alumen powder that second step obtains, the Indian Madder Root that the 3rd step obtains also joins in this alcoholic solution, by alcoholic solution reflux 3～6 hours, leave standstill cooling, filter, obtain the first filtrate, in the ethanol that it is 90%～95% that filtering residue adds with respect to the determining alcohol of 3～5 times of its quality again, reflux 3～6 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain traditional Chinese medicine composition extract liquid, concentrating under reduced pressure is removed ethanol, obtain and get dry extract, pulverize, to entering in water, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml～2g/ml.
Traditional Chinese medicine composition extract liquid 1
By the stripping and slicing of 55g Radix Et Rhizoma Rhei, the yellow wine that adds 10g stirs, vexed, is placed in frying pan, fry 50 minutes with slow fire, take out, leave standstill cooling, be ground into powder with pulverizer, obtain Radix et Rhizoma Rhei (stir-fried with wine), 50g Alumen is cleaned, pound into fritter, be placed in container, be fired to when crisp, take out, cool, be ground into powder with pulverizer, obtain dried Alumen, 45g Radix Rubiae is put into frying pan and fry into charcoal, be ground into smalls with pulverizer, by Gypsum Fibrosum 47g, Radix Liriopes 44g, Herba Houttuyniae 31g, Myrrha 17g, Semen Arecae 15g, Fructus Crataegi 22g, Radix Paeoniae Rubra 43g, Folium Et Cacumen Murrayae 35g, Rhizoma Coptidis 88g, Radix Asparagi 33g, Radix Achyranthis Bidentatae 45g, Rhizoma Cimicifugae 20g, Caulis Mahoniae 34g, Radix Panacis Quinquefolii 62g, Cacumen Platycladi 56g, Herba Sarcandrae 32g, Herba Lycopi 19g, Folium Ilicis Cornutae 31g, Caulis Trachelospermi 33g, Radix Angelicae Dahuricae 40g, Flos Lonicerae 56g sends in pulverizer and pulverizes respectively, sends into subsequently in blender and stirs 40 minutes, in the ethanol that the determining alcohol that is poured into 3200g is 95%, by the 47g Radix et Rhizoma Rhei (stir-fried with wine) powder of preparing above, 46g dried Alumen powder, 45g Indian Madder Root also joins in this alcoholic solution, by alcoholic solution reflux 6 hours, leave standstill cooling, filter, obtain the first filtrate, it is in 95% ethanol that filtering residue adds 1200g determining alcohol again, reflux 5 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is removed ethanol, obtains and gets dry extract, and pulverizes, to entering in the water of 900ml, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml, obtain traditional Chinese medicine composition extract liquid 1.
Traditional Chinese medicine composition extract liquid 2
By the stripping and slicing of 55g Radix Et Rhizoma Rhei, the yellow wine that adds 10g stirs, vexed, is placed in frying pan, fry 50 minutes with slow fire, take out, leave standstill cooling, be ground into powder with pulverizer, obtain Radix et Rhizoma Rhei (stir-fried with wine), 50g Alumen is cleaned, pound into fritter, be placed in container, be fired to when crisp, take out, cool, be ground into powder with pulverizer, obtain dried Alumen, 45g Radix Rubiae is put into frying pan and fry into charcoal, be ground into smalls with pulverizer, by Gypsum Fibrosum 50g, Radix Liriopes 46g, Herba Houttuyniae 33g, Myrrha 19g, Semen Arecae 16g, Fructus Crataegi 20g, Radix Paeoniae Rubra 47g, Folium Et Cacumen Murrayae 33g, Rhizoma Coptidis 88g, Radix Asparagi 35g, Radix Achyranthis Bidentatae 43g, Rhizoma Cimicifugae 19g, Caulis Mahoniae 32g, Radix Panacis Quinquefolii 59g, Cacumen Platycladi 53g, Herba Sarcandrae 30g, Herba Lycopi 24g, Folium Ilicis Cornutae 36g, Caulis Trachelospermi 30g, Radix Angelicae Dahuricae 42g, Flos Lonicerae 59g sends in pulverizer and pulverizes respectively, sends into subsequently in blender and stirs 40 minutes, in the ethanol that the determining alcohol that is poured into 3200g is 95%, by the 45g Radix et Rhizoma Rhei (stir-fried with wine) powder of preparing above, 43g dried Alumen powder, 42g Indian Madder Root also joins in this alcoholic solution, by alcoholic solution reflux 6 hours, leave standstill cooling, filter, obtain the first filtrate, it is in 95% ethanol that filtering residue adds 1200g determining alcohol again, reflux 5 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is removed ethanol, obtains and gets dry extract, and pulverizes, to entering in the water of 900ml, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml, obtain traditional Chinese medicine composition extract liquid 2.
Acute toxicity testing
The traditional Chinese medicine composition extract liquid of preparing above 1 and traditional Chinese medicine composition extract liquid 2 concentrating under reduced pressure are obtained and got dry extract, pulverize, be dissolved in the suspension 1 and the suspension 2 that in water, are prepared into 1g/ml, choose mice hero, female each 20, be divided into 2 groups, every group 20, gavage suspension 1 and suspension 2, all by the dosage gastric infusion of 10g (crude drug)/kg, after gavage, observe and within 72 hours, have no dead mouse, show that Chinese medicine composition dosis tolerata of the present invention is large, LD
50do not measure.
Toothpaste 1
The traditional Chinese medicine composition extract liquid 1 that 25g is prepared above, 42g wetting agent glycerol (pharmaceutical grade, Anhui Yuan Xiang medicinal liquid company limited produces), 2g Surfactant SDS (cosmetics-stage, Anhui Shanhe Medicinal Subsidiary Material Co., Ltd. produces), 3.5g distilled water, 2g antibacterial Lanthanum (III) nitrate (analytical pure, Shun Qing chemical plant, Jinan) put into batch mixer stir mixing and drop into azeotropic pot after evenly, be heated to 100 DEG C, be cooked into colloid, be cooled to 70 DEG C of left and right, stand-by, azeotropic pot is put on agitator, under stirring state (rotating speed 350r/min), accurately take 22g abrasivus calcium carbonate (pharmaceutical grade) with electronic balance, 3g binding agent sodium carboxymethyl cellulose (pharmaceutical grade, Anhui KeYu Chemical Co., Ltd. produces), 1.5g sweeting agent glucide (food stage), 1g stabilizing agent carbamide (pharmaceutical grade, Xin Longhai pharmaceutcal corporation, Ltd of Anhui Province produces), drop into one by one in order in azeotropic pot, continue to stir 4 hours with agitator, rotating speed is 350r/min, make various mixing of materials even, now temperature reduces gradually, treat that colloid is cooled to 50 DEG C, move to and on chaser, grind 2h, be chilled to 40 DEG C, pack in flexible pipe and seal and obtain toothpaste 1.
Toothpaste 2
The traditional Chinese medicine composition extract liquid 2 that 25g is prepared above, 40g wetting agent glycerol (pharmaceutical grade), 2g Surfactant SDS (cosmetics-stage), 2.5g distilled water, 2g antibacterial Lanthanum (III) nitrate (analytical pure) is put into the evenly rear azeotropic pot that drops into of batch mixer stir mixing, be heated to 100 DEG C, be cooked into colloid, be cooled to 70 DEG C of left and right, stand-by, azeotropic pot is put on agitator, under stirring state (rotating speed 350r/min), accurately take 25g abrasivus calcium carbonate (pharmaceutical grade) with electronic balance, 3g binding agent sodium carboxymethyl cellulose (pharmaceutical grade), 1.5g sweeting agent glucide (food stage), 1g stabilizing agent carbamide (pharmaceutical grade), drop into one by one in order in azeotropic pot, continue to stir 4 hours with agitator, rotating speed is 350r/min, make various mixing of materials even, now temperature reduces gradually, treat that colloid is cooled to 50 DEG C, move to and on chaser, grind 2h, be chilled to 40 DEG C, pack in flexible pipe and seal and obtain toothpaste 2.
Anti-inflammatory experiment
Mice modeling experiment
Animal
SPF level SD rat, male, 280～300g, totally 30, be divided into 2 groups, 15 every group, provided by Beijing Vital River Experimental Animals Technology Co., Ltd., raise in the SPF of Xuan Wu hospital level laboratory animal breeding room.
Instrument
Multi-channel laser Doppler blood flowmeter PeriFlux4001 type, purchased from PERIMED company of Sweden, 7150 type automatic biochemistry analyzers, purchased from Hitachi, Ltd.
Modeling method
Under pentobarbital sodium anesthesia, tie the two lower incisor neck of rat portion with silk thread, and on gingiva, stitch two pins and fix, the normal mice of feeding after operation material, drink 10% sucrose water, after 7 days, chooses every group of successful mice of 10 modelings and continues experiment.
Experimental technique
Get 3.23g and be dissolved in 100ml normal saline, make a 3.25% clinical multiple dose solution, to wherein one group as experimental group, fully be applied in affected part with soaking the completely Cotton Gossypii of this solution, morning and afternoon respectively once, successive administration 7 days, another group gives normal saline as a control group.
Detect index
Regional flow measures
By on rearmounted rat anesthesia operating-table, laser doppler blood flow probe is fixed on the locating rack of brain solid positioner, regulates probe orientation also to contact gently with lower incisor gingival mucosa surface is vertical, records the blood flow of 2min.Instrument can calculate mean blood flow, blood flow rate and cell number automatically.
Level in gingival sulcus fluid AST assay
The filter paper bar of getting 2mm × 4mm is placed in gingival mucosa surface 60s between two lower incisors, takes out filter paper, drops into and is equipped with in the micro-centrifuge tube of 0.5mL normal saline, on suspendible device, shakes 60s, and-70 DEG C of preservations adopted automatic clinical chemistry analyzer to measure AST in 1 week.Adopt the change of precision balance weighing filter paper quality simultaneously, draw the quality of level in gingival sulcus fluid, for gingival crevicular fluid is proofreaied and correct.
Statistical procedures
All experimental datas with
represent, utilize SPSS11.0 statistical software, its significance of t inspection inspection between employing group.
The change of table 1 rat experiment gingivitis regional flow and level in gingival sulcus fluid AST level
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (4)
1. a traditional Chinese medicine composition extract liquid for the treatment of gingivitis, is characterized in that: be only made up of Gypsum Fibrosum, Radix Liriopes, Herba Houttuyniae, Myrrha, Semen Arecae, Fructus Crataegi, Radix Paeoniae Rubra, Folium Et Cacumen Murrayae, Radix et Rhizoma Rhei (stir-fried with wine), Rhizoma Coptidis, Radix Asparagi, Radix Achyranthis Bidentatae, Rhizoma Cimicifugae, Caulis Mahoniae, dried Alumen, Radix Panacis Quinquefolii, Cacumen Platycladi, Radix Rubiae, Herba Sarcandrae, Herba Lycopi, Folium Ilicis Cornutae, Caulis Trachelospermi, the Radix Angelicae Dahuricae, Flos Lonicerae, the weight portion of each component is respectively Gypsum Fibrosum 42～52 weight portions, Radix Liriopes 39～49 weight portions, Herba Houttuyniae 26～36 weight portions, Myrrha 12～22 weight portions, Semen Arecae 10～20 weight portions, Fructus Crataegi 17～27 weight portions, Radix Paeoniae Rubra 38～48 weight portions, Folium Et Cacumen Murrayae 30～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 37～47 weight portions, Rhizoma Coptidis 78～88 weight portions, Radix Asparagi 28～38 weight portions, Radix Achyranthis Bidentatae 40～50 weight portions, Rhizoma Cimicifugae 15～25 weight portions, Caulis Mahoniae 29～39 weight portions, dried Alumen 36～46 weight portions, Radix Panacis Quinquefolii 52～62 weight portions, Cacumen Platycladi 46～56 weight portions, Radix Rubiae 40～50 weight portions, Herba Sarcandrae 27～37 weight portions, Herba Lycopi's 19～29 weight portions, Folium Ilicis Cornutae 31～41 weight portions, Caulis Trachelospermi 28～38 weight portions, the Radix Angelicae Dahuricae 35～45 weight portions, Flos Lonicerae 51～61 weight portions,
The preparation method of described Chinese medicine composition, is characterized in that, comprising:
The first step, by Radix Et Rhizoma Rhei stripping and slicing, the yellow wine that adds 0.1～0.2 weight portion stirs, vexed, is placed in parch container, fries 30～50 minutes with slow fire, takes out, and leaves standstill cooling, is ground into powder with pulverizer, obtains Radix et Rhizoma Rhei (stir-fried with wine);
Second step, cleans Alumen, pounds into fritter, is placed in container, is fired to when crisp, takes out, and cools, and is ground into powder with pulverizer, obtains dried Alumen;
The 3rd step, puts into frying pan by Radix Rubiae and fries into charcoal, is ground into smalls with pulverizer;
The 4th step, remaining component is sent in pulverizer and pulverized respectively, send into subsequently in blender and stir 20 minutes～40 minutes, in the ethanol that to be poured into respect to the determining alcohol of 3～5 times of its quality be 90%～95%, the Radix et Rhizoma Rhei (stir-fried with wine) powder that the first step is obtained, the dried Alumen powder that second step obtains, the Indian Madder Root that the 3rd step obtains also joins in this alcoholic solution, by alcoholic solution reflux 3～6 hours, leave standstill cooling, filter, obtain the first filtrate, in the ethanol that it is 90%～95% that filtering residue adds with respect to the determining alcohol of 3～5 times of its quality again, reflux 3～6 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain traditional Chinese medicine composition extract liquid, concentrating under reduced pressure is removed ethanol, obtain and get dry extract, pulverize, be poured into water, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml～2g/ml.
2. traditional Chinese medicine composition extract liquid as claimed in claim 1, it is characterized in that: the weight portion of each component is respectively Gypsum Fibrosum 47～52 weight portions, Radix Liriopes 44～49 weight portions, Herba Houttuyniae 26～31 weight portions, Myrrha 12～17 weight portions, Semen Arecae 10～15 weight portions, Fructus Crataegi 17～22 weight portions, Radix Paeoniae Rubra 38～43 weight portions, Folium Et Cacumen Murrayae 35～40 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 42～47 weight portions, Rhizoma Coptidis 83～88 weight portions, Radix Asparagi 33～38 weight portions, Radix Achyranthis Bidentatae 45～50 weight portions, Rhizoma Cimicifugae 20～25 weight portions, Caulis Mahoniae 34～39 weight portions, dried Alumen 41～46 weight portions, Radix Panacis Quinquefolii 57～62 weight portions, Cacumen Platycladi 51～56 weight portions, Radix Rubiae 45～50 weight portions, Herba Sarcandrae 32～37 weight portions, Herba Lycopi's 19～24 weight portions, Folium Ilicis Cornutae 31～36 weight portions, Caulis Trachelospermi 33～38 weight portions, the Radix Angelicae Dahuricae 40～45 weight portions, Flos Lonicerae 56～61 weight portions.
3. traditional Chinese medicine composition extract liquid as claimed in claim 1 or 2, it is characterized in that: the weight portion of each component is respectively Gypsum Fibrosum 47 weight portions, Radix Liriopes 44 weight portions, Herba Houttuyniae 31 weight portions, Myrrha 17 weight portions, Semen Arecae 15 weight portions, Fructus Crataegi 22 weight portions, Radix Paeoniae Rubra 43 weight portions, Folium Et Cacumen Murrayae 35 weight portions, Radix et Rhizoma Rhei (stir-fried with wine) 47 weight portions, Rhizoma Coptidis 88 weight portions, Radix Asparagi 33 weight portions, Radix Achyranthis Bidentatae 45 weight portions, Rhizoma Cimicifugae 20 weight portions, Caulis Mahoniae 34 weight portions, dried Alumen 46 weight portions, Radix Panacis Quinquefolii 62 weight portions, Cacumen Platycladi 56 weight portions, Radix Rubiae 45 weight portions, Herba Sarcandrae 32 weight portions, Herba Lycopi's 19 weight portions, Folium Ilicis Cornutae 31 weight portions, Caulis Trachelospermi 33 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Flos Lonicerae 56 weight portions.
4. the preparation method of traditional Chinese medicine composition extract liquid described in claims 1 to 3 any one, is characterized in that, comprising:
The first step, by Radix Et Rhizoma Rhei stripping and slicing, the yellow wine that adds 0.1～0.2 weight portion stirs, vexed, is placed in parch container, fries 30～50 minutes with slow fire, takes out, and leaves standstill cooling, is ground into powder with pulverizer, obtains Radix et Rhizoma Rhei (stir-fried with wine);
Second step, cleans Alumen, pounds into fritter, is placed in container, is fired to when crisp, takes out, and cools, and is ground into powder with pulverizer, obtains dried Alumen;
The 3rd step, puts into frying pan by Radix Rubiae and fries into charcoal, is ground into smalls with pulverizer;
The 4th step, remaining component is sent in pulverizer and pulverized respectively, send into subsequently in blender and stir 20 minutes～40 minutes, in the ethanol that to be poured into respect to the determining alcohol of 3～5 times of its quality be 90%～95%, the Radix et Rhizoma Rhei (stir-fried with wine) powder that the first step is obtained, the dried Alumen powder that second step obtains, the Indian Madder Root that the 3rd step obtains also joins in this alcoholic solution, by alcoholic solution reflux 3～6 hours, leave standstill cooling, filter, obtain the first filtrate, in the ethanol that it is 90%～95% that filtering residue adds with respect to the determining alcohol of 3～5 times of its quality again, reflux 3～6 hours, leave standstill cooling, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, obtain traditional Chinese medicine composition extract liquid, concentrating under reduced pressure is removed ethanol, obtain and get dry extract, pulverize, be poured into water, boil dissolving, obtain the extracting solution of crude drug concentration 1g/ml～2g/ml.
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Owner name: QINGDAO HUAREN TECHNOLOGY INCUBATOR CO., LTD. Free format text: FORMER OWNER: LIU BINGTIAN Effective date: 20141028 |
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Inventor after: Song Zhenyu Inventor after: Zhang Li Inventor before: Liu Bingtian |
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Free format text: CORRECT: INVENTOR; FROM: LIU BINGTIAN TO: SONG ZHENYU ZHANG LI |
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Effective date of registration: 20141028 Address after: 266071 Shandong city of Qingdao province Hongkong City Road No. 32 floor 801-A room 8 Applicant after: Qingdao Huaren Technology Incubator Co., Ltd. Address before: Taizhou City, Shandong province Qingdao City Road 266071 No. 5 unit 3, room 402 Applicant before: Liu Bingtian |
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Address after: 266071 Shandong city of Qingdao province Hongkong City Road No. 32 floor 801-A room 8 Patentee after: Qingdao Huaren Technology Incubator Co., Ltd. Address before: 266071 Qingdao City, Shandong Province Patentee before: Qingdao Huaren Technology Incubator Co., Ltd. |
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Correction item: Address of the patentee Correct: Shandong City, Qingdao province Hongkong City Road No. 32 8 floor room 801 False: Qingdao, Shandong, China Number: 49 Volume: 30 |
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Correction item: Address of the patentee Correct: Shandong City, Qingdao province Hongkong City Road No. 32 floor 801-A room 8 False: Qingdao, Shandong, China Number: 49 Page: The title page Volume: 30 |
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Effective date of registration: 20171023 Address after: Lang Jun Center No. 28 road 401120 Chongqing city Yubei District Huanglong longta Street Building 3 2-1 Patentee after: Chongqing AOPO Ruisen Technology Co. Ltd. Address before: 266071 Shandong city of Qingdao province Hongkong City Road No. 32, Minmetals Building 8 801-A room Patentee before: Qingdao Huaren Technology Incubator Co., Ltd. |
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Effective date of registration: 20180529 Address after: 401120 293 Xingcheng Avenue, Hui Xing street, Yubei District, Chongqing, with 7 buildings 9. Patentee after: CHONGQING XUANNU BIOTECHNOLOGY CO., LTD. Address before: 401120, 3, 2-1, Langjun center, 28 Huanglong Road, Dragon Tower Street, Yubei District, Chongqing. Patentee before: Chongqing AOPO Ruisen Technology Co. Ltd. |
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Granted publication date: 20141203 Termination date: 20190403 |