CN103181562B - A kind of have health food of Summertime health-care effect and preparation method thereof - Google Patents
A kind of have health food of Summertime health-care effect and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of health food, particularly a kind of for treating myocardial ischemia, Improving memory power summer and improving the health food of heat-resisting ability and preparation method, relate to the novelty teabag of said composition simultaneously.This health food is made up of radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle and green tea.This Ricipe for health care food not only has adjustment body internal organs qi and blood, promote that body complies with traditional function of negative and positive Changing Pattern in summer, and have and improve hemorheological property and antagonism acute myocardial ischemia, Improving memory ability and improve the Modern Utility Theory such as body heat-resisting ability.
Description
Invention field
The present invention relates to a kind of being specially adapted to and treat myocardial ischemia, Improving memory power and the health food improving heat-resisting ability and preparation method thereof summer, relate to the novelty teabag of said composition simultaneously.
Background technology
The present invention relates to modern health care and traditional Chinese medical science four seasons diet regimen field.
Summer has " gas the moon is consumed for hot climate, letting out of YANG QI,aberration of YANG QI " and " Xia Yingxin " and human body easily tired, an easy feature such as summer-heat disease and cardiovascular and cerebrovascular disease Yi Fa, summer nourishment maintenance should " clearing summer-heat and damp and in; supplementing qi and nourishing yin protects the heart " be principle, namely eliminate hot summer weather, smooth dredging water passages; Help spleen stomach invigorating to improve a poor appetite; Help body internal consumption, improves the anti-heat ability of body; Nourish heart and adjust god, regulate blood circulation and cardiac function and improve memory, prevent the recurrence of cardiovascular and cerebrovascular disease and improve work efficiency.
Myocardial ischemia refers to that a variety of causes causes coronary blood flow to reduce, and causes the under-supply clinical state reduced with metabolite removing of the materials such as myocardium oxygen.It can caused by coronary heart disease and non-coronary heart disease.Methods for the treatment of is mainly based on traditional Chinese medicine.Myocardial ischemia all may bring many adverse effects to heart and whole body.Oxygen is the movable requisite material of cardiac muscle cell, and oxygen by blood transport to cell.Heart does not have " oxygen warehouse ", relies on myocardial blood flow completely, so once ischemic, can cause anoxic at once.The direct result of anoxic is that cardiac muscle cell's aerobic metabolism weakens, and production capacity reduces, and energy required when making cardiomotility is under-supply, causes angina pectoris, arrhythmia cordis, heart function to decline.Patients with Myocardial Ischemia should select low cholesterol, low animal fat, low in calories, glucose-diet, and many drinking water fruits, vegetables and appropriate protein, avoid eating and drinking immoderately, and advises it to give up cigarette, wine.
Memory refers to that brain cell survival enlivens, and the quality with brain cell is relevant, also relevant with memory style.The reason of decrease of memory is varied, and the memory of the elderly goes down with very slow speed along with the aging of each organ of health, and this is the natural law, is also normal phenomenon.Delay to be losing one's memory and to strengthen memory, the most important thing is to lose the confidence to the memory of oneself.Meanwhile, the elderly also must supplement the nutriments such as protein, trace element, vitamin in right amount in time, gives up cigarette, wine, notes memory health.Patient should note edible fresh veterinary antibiotics and following several food in the diet: corn, coarse rice, full wheat, soya bean, mung bean, the head of garlic, mushroom, yeast, milk, animal's liver, sardine, tuna, lean meat class etc.
Under summer high temperature environment, make owing to perspiring in a large number that blood of human body is concentrated, blood vessel dilatation, cause the increase of peripheral blood circulation; Work under hot environment, the CBF of muscle also can increase, and these factors all may cause heartbeat to be overrun, and Pulse pressure reduces, thus increases the weight of heart burden, causes blood pressure.
Diet regimen when four
Health preserving in four seasons is exactly the principle according to the traditional Chinese medical science " correspondence between man and universe ", according to the rule of Human Physiology reform of nature circle YIN YANG in four seasons change, initiatively take to comprise the multiple proper method such as rule of life, diet, motion, spirit, to improve the physiological fitness of body, farthest playing naturally treating of human body can, go after profits and advoid disadvantages, the object of reach illness prevention and fitness, promoting longevity.Wherein according to four time apolegamy suitable food, to reach salubrious method, i.e. four seasons dietary regimen.
In the clinical practice of the traditional Chinese medical science, medicine is relative with the division of food, because most of Chinese medicine can eat, medicine and the difference of food are different on a consumption, and the amount that toxic action is large is little, and the little amount of toxic action is large.Simultaneously for some foods with medicine and the double function of food, its medicine is also only its different objects used from the difference of food.Its side effect of food on ordinary meaning is little, has very large amount ranges, is mainly used in strengthening by means of tonics; And medicine has certain side effect, amount ranges is smaller, is mainly used in disease therapy.Some of them had both been had the food effect of allaying one's hunger by empirical evidence, had again the Chinese medicine of strong treatment disease effect, and because it has medicine food dual-use function, and have good security, what become diet regimen mainly selects object always.When four, diet regimen is then the principle according to the traditional Chinese medical science " integration of drinking and medicinal herbs " and " correspondence between man and universe ", draws the experience of the traditional Chinese medical science " four seasons health ", and what answer the different Changeization Jin eclipse seaseon Festival of season Festival during " spring, summer, autumn and winter " four to nourish medicine Shi ， Said is that four seasons Yin Shi Fill is good for.
Four seasons diet regimen relates to " to eat As Fill ", the empirical content such as " food get Qi Fa " and " eat and Time ".But about four time diet regimen a large amount of experiences only sporadically appear in successive dynasties medical book, and content is mainly concerned with the compatibility and incompatibility of drugs food that the four seasons use records, wherein and medicine feeding habits energy theoretical according to traditional Chinese medical science Health preserving in four seasons and the proposition of compound compatibility feature then little for the formula being specifically designed to Health preserving in four seasons.The various tea beverage that modern market has many nominals with health role, between can see as the four seasons use the Chinese medicine herbal tea (four seasons tea) that goes out of specialized designs, but its formula still lacks necessary traditional Chinese medicine scientific principle and the support of experiential basis, and it especially can not be provided to have the evidence of four seasons health care effectiveness.This series products is the bagged instant preparation belonging to crude drug that suitable boiling water brews and slightly fall apart also more, exist effective components utilising degree not high, use inconvenience and the problem such as mouthfeel is not good.
The traditional Chinese medical science is thought, as medicine, food also has its respective performance, comprise the content such as nature and flavor (fever and chills and warm and cool four gas and the pungent salty five tastes of sour sweetness and bitterness), Gui Jing, lifting sink-float, reinforcing and reducing methods, the food of different performance can produce different functions by different compatibility, the imbalance of body internal organs yang blood and qi can be corrected, play health care (prevention, body-building, rehabilitation etc.) effect.
Summary of the invention
One object of the present invention is openly a kind of health food being applicable to treat myocardial ischemia, Improving memory power summer and improve heat-resisting ability; Another object of the present invention is to disclose the preparation method that this is applicable to Summertime food for health care; One object of the present invention is also to disclose the novelty teabag that this is applicable to Summertime food for health care.
The bulk drug composition of health food of the present invention and proportioning following (by weight):
Health food preferred feedstock medicine proportioning of the present invention can be:
Health food preferred feedstock medicine proportioning of the present invention can also be:
Health food preferred feedstock medicine proportioning of the present invention can also be:
By practice of pharmacy, the invention described above health-care food composition can be added customary adjuvant and conventionally be prepared into various clinical formulation, comprise the formulation of oral formulations or parenterai administration.Said oral formulations is selected from the one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
Health food of the present invention also can add conventional health food excipient, as solvent, disintegrant, flavouring, anticorrisive agent, colouring agent etc.
The preparation method of health food extract of the present invention is following method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 1-3 hour, decoct and extract 2-4 time, each 0.5-1.5 hour, amount of water is 6-12 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.01 ~ 1.10, for subsequent use; Get shitosan, add 1% acetum of 80-120 times of weight, be heated to 30-60 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3%-4%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.20 ~ 1.40, and drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder.
The preparation method of health food extract of the present invention is preferably following method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, and drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder.
The preparation method of health food of the present invention is following method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 1-3 hour, decoct and extract 2-4 time, each 0.5-1.5 hour, amount of water is 6-12 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.01 ~ 1.10, for subsequent use; Get shitosan, add 1% acetum of 80-120 times of weight, be heated to 30-60 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3%-4%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.20 ~ 1.40, adds its weight 2-4 dextrin doubly and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; The dolomol adding its weight 15%-25% mixes, and adds customary adjuvant and is conventionally prepared into one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
The preparation method of health food of the present invention is preferably following method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; The chitosan solution of its weight 3.6% is added in concentrate A, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, the dextrin adding its weight 3 times mixes, and adds customary adjuvant and is conventionally prepared into one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
The present invention relates to a kind of health food, particularly a kind of for treating myocardial ischemia, Improving memory power summer and improving the health food of heat-resisting ability and preparation method, relate to the novelty teabag of said composition simultaneously.This health food is made up of radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle and green tea.This health food is according to above-mentioned traditional Chinese medical science health-through-dining theory in spring and clinical practice experience, in conjunction with the theory of modern prevention and health care and modern society environment, human lives's patterns of change and summer the feature such as disease incidence type, utilize the medicine of food eat the experience of function and traditional Chinese medical science physical property matching and invent a diet formulation being suitable for crowd's health in summer of development.By adopting advanced technology, fully retaining the nutrition of food, extracting the elite of draft, and by suitable flavoring and flavoring technology, be mixed with and be convenient to drink or edible dosage form.This Ricipe for health care food not only has adjustment body internal organs qi and blood, promote that body complies with traditional function of negative and positive Changing Pattern in summer, and not only have and improve hemorheological property and antagonism acute myocardial ischemia, and there is certain Improving memory, improve effect and the Modern Utility Theory such as high temperature resistant.
Figure of description
Fig. 1: Summertime tea is on the impact (HE, 10 × 10) of Model of Acute Myocardial Ischemia rat heart muscle pathology change in organization.
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
Experiment of the present invention all adopts following material.
Medicine and reagent: health food of the present invention: Summertime tea (extract prepared by embodiment 8), 8.5g particle/sky, is provided by Beijing University of Chinese Medicine's state key Academic Area " Pharmacology of Chinese medicine Formulae, lot number: 201003012.Compound danshen dripping pills, Tianjin Tian Shili group produces, and lot number is: 20080722.Piracetam, Shanghai Sine Pharmaceutical Co., Ltd. produces, lot number: 090915.Scopolamine hydrobromide injection, Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number: 090403.Lactic dehydrogenase (LDH), creatine kinase (CK) testing cassete, Nanjing is built up Bioengineering Research Institute and is produced, lot number: 201000118; Natrium nitrosum, Shanghai Zhen Xin chemical reagent work produces, lot number: 200810003.
Animal: Kunming mouse, 20-24g, male female dual-purpose; SD rat, 220 ± 20g, provides by animal used as test Technology Co., Ltd. of dimension tonneau China of Beijing, animal credit number: SCXK (capital) 2009-003 and SCXK (capital) 2009-015.
Instrument: 754-spectrophotometer, Shanghai Scientific Instruments Corporation produces; DT-200 diving tower instrument, BA-200 keep away dark instrument, and Chengdu Tai Meng Scientific Instruments Corporation produces; YDA-IV type blood rheological instrument, Beijing Hong Run reaches development in science and technology Co., Ltd and produces; High speed freezing centrifuge; Olympus microscope.
experimental example 1:the effect experiment of health food Summertime tea of the present invention
One, experimental technique
1, Summertime tea is to the protective effect of Model of Acute Myocardial Ischemia animal
Laboratory work condition: temperature 18-22 DEG C, humidity 55-65%.Getting body weight is 200-220g rat, male and female half and half, be divided at random sham-operation group, model group, positive group (compound danshen dripping pills), health preserving tea little, in, heavy dose of group (0.70,1.40,2.80g particle/kg, calculate by kg body weight, be equivalent to (5,10,20 times) of people's consumption 8.5g particle/kg, often organize 12, each treated animal according to dosage continuous 7 days of gastric infusion.Sham-operation group, model group give isometric(al) distilled water, after last administration 30 minutes, etherization, open chest in left 4th intercostal, expose heart, with 5-0 line-spacing arteria coroaria sinistra root 2-3mm place's ligation coronary artery, close chest, cause ami model, sham-operation group does respective handling but not ligation.Each group of Rat Ecg is measured respectively at operation consent, Post operation, Post operation 0.5h, 1h, 2h.After ligation 24 hours, 10% chloral hydrate anesthesia animal, abdominal aortic blood, measures Serum fibrosis markers (CPK, LDH) changes of contents, hemorheological property; Calculating myocardium infraction weight (TTC dyeing) also gets the pathologic diagnosis (HE dyeing) that part heart carries out cardiac muscle.
2, Summertime tea is on the impact of mouse hot conditions lower time-to-live
Getting body weight is 18-22g mouse 100, be divided into normal group at random, positive group (Composite Salvia Dropping Pill group, 0.32g/kg), health preserving tea is little, in, heavy dose of group (is respectively 1.11, 3.32, 9.95g/kg, calculate by body surface area, be equivalent to 1 of people's consumption 8.5g particle/sky, 3, 9 times), often organize 20, each group of according to dosage gastric infusion, continuous 7 days, normal group gives isometric(al) distilled water, after last administration 30 minutes, mouse is put into the insulating box of (45 ± 1 DEG C), the time-to-live of record mouse, (50 minutes were not dead, calculated by 50 minutes) and 50 minutes each group survival number.
3, Summertime tea is on the impact of learning and memory of little mouse
Memory acquisition disturbance model mice learning and memory is affected
Laboratory work condition: temperature 18-22 DEG C, humidity 55-65%.Get body weight 18-22g mouse 60, male and female half and half, be divided into normal group, model group, positive group of (piracetam group at random, 1.87g/kg), health preserving tea little, in, heavy dose of group (be respectively 1.11,3.32,9.95g particle/kg, calculate by body surface area, be equivalent to 1,3,9 times of people's consumption 8.5g particle/sky), each treated animal is the continuous 10d of gastric infusion according to dosage, and normal group, model group give isometric(al) distilled water.30min other each treated animal lumbar injection scopolamine hydrobromide 5mg/kg except normal group after last administration, diving tower training is carried out after 20min, mouse is put into diving tower tester and adapt to 3min, open power supply (voltage 28V) and carry out training 5min, the test of study situation is carried out after 24h, be placed on by mouse on diving tower, record mouse is from the errors number of the incubation period that platform jumps off and 5min.
Two, data processing and statistics
Data all adopt
represent, compare between the group between multiple sample and adopt one-way analysis of variance (one-wayANOVA), carry out SNK-Q inspection and carry out Chi-square Test.Total data adopts SPSS13.0 software to process.
Three, experimental result
1, Summertime tea is to the protective effect of Model of Acute Myocardial Ischemia rat
(1) Summertime tea is on the impact of Model of Acute Myocardial Ischemia Rat Ecg ST section
The results are shown in Table 1.
Table 1 Summertime tea on the impact of Model of Acute Myocardial Ischemia Rat Ecg ST section (
n=10)
With sham-operation group ratio, * P < 0.05; With model group ratio, #P < 0.05.
From table 1, each time point ECG ST section that rat respectively organized by modeling and medicine raises value obviously increase, and difference all has significant (P < 0.05) compared with sham-operation group.Compared with model group, administration is respectively organized so-called Rat Ecg ST section and is all seen reduction in various degree, wherein Post operation Summertime tea small dose group and heavy dose of group; The difference of Post operation 0.5h Danshen Root dropping ball group all has significant (P < 0.05).
(2) Summertime tea is on the impact of Model of Acute Myocardial Ischemia rat myocardial infarction model rate
The results are shown in Table 2.
Table 2 Summertime tea on the impact of Model of Acute Myocardial Ischemia rat myocardial infarction model rate (
n=6)
With model group ratio, #P < 0.05.
From table 2, compare with model group, the infarct weight of each medicine group rat of successive administration after 7 days and infarct rate are all shown in and reduce in various degree, and wherein the middle dosage of Danshen Root dropping ball group, health preserving tea and the difference of heavy dose of amount group all have significant (P < 0.01 or P < 0.05).
(3) Summertime tea is to Model of Acute Myocardial Ischemia rat blood serum LDH, CK activity influence
The results are shown in Table 3.
Table 3 Summertime tea to Model of Acute Myocardial Ischemia rat blood serum LDH, CK activity influence (
n=10)
With sham-operation group ratio, * P < 0.05; * P < 0.01; With model group ratio, #P < 0.05, ##P < 0.01.
From table 3, compare with sham-operation group, coronary ligation after 24 hours in model group rat blood serum LDH, CK activity all significantly raise, difference has significant (P < 0.05).Compare with model group, rat blood serum LDH and CK of Danshen Root dropping ball and each dosage group of Summertime tea all has and reduces in various degree, and each group difference all has significant (P < 0.01 or P < 0.05).
(4) Summertime tea is on the impact of Model of Acute Myocardial Ischemia rat heart muscle pathology change in organization
The myocardium HE testing each group of rat contaminates sheet in light Microscopic observation.Observe the heart wall cardiac muscle cell marshalling of sham-operation group, kytoplasm even dyeing, core is in circle or oval, and Distribution of chromatin is even.The cardiac muscle cell of model group is multifocal, sheet coagulation necrosis, karyolysis, cracked, subregion hypochromatosis, and cytoplasm dyeing is deepened, and interstitial blood vessel dilatation is obviously congested, and tissue looseness's oedema accompanies a large amount of neutrophil infiltration.Indivedual heart external membrane of heart inflammatory exudate attachment.Cardiac muscle cell's stove coagulation necrosis of positive drug Danshen Root dropping ball group, scope is little compared with model group, karyolysis, cracked, regional area hypochromatosis, and cytoplasm dyeing is deepened, and interstitial blood vessel dilatation is congested, tissue looseness oedema companion neutrophil infiltration.Cardiac muscle cell's coagulation necrosis scope of Summertime tea group is less, and in point-like, special mess shape, middle dosage group and heavy dose of group part heart are based on muscular degeneration of heart, and infarct is not obvious.Infarcted region karyopyknosis, swelling, a small amount of karyolysis, cracked, cell volume diminishes, cytoplasm dyeing is deepened, subregion interstitial blood vessel dilatation is congested, and tissue looseness's oedema accompanies a small amount of neutrophil infiltration, and wherein, dosage group and heavy dose of group pathology obviously alleviate.The results are shown in Table 4 to table 6 and Fig. 1.
Table 4 is group Model of Acute Myocardial Ischemia rat heart muscle coagulation necrosis degree respectively
Table 5 is the interstitial hyperemia of group Model of Acute Myocardial Ischemia rat heart muscle and extent of hemorrhage respectively
Table 6 is group Model of Acute Myocardial Ischemia rat heart muscle interstitial cell infiltration degree respectively
As can be seen from table 4-6 and Fig. 1, comparing with normal group, there is obvious Myocardial damage in model group rats cardiac muscular tissue, shows as myocardium coagulation necrosis and interstitial pathology.Compare with model group, in Danshen Root dropping ball and Summertime tea, cardiac muscular tissue's pathology of heavy dose of group rat all has and obviously alleviates, and wherein Summertime tea presents dose-effect relationship.
2, Summertime tea is on the impact of mouse hot conditions lower time-to-live
The results are shown in Table 7.
Table 7 Summertime tea on the mouse survival time under hot conditions and survival number impact (
n=20)
With normal group ratio, * P < 0.05.
From table 7, compare with Normal group, successive administration 7 days, all there is prolongation list no significant difference (P > 0.05) in various degree the time-to-live under each administration group mouse hot conditions; The survival number of each administration treated animal has increase, wherein Danshen Root dropping ball group, Summertime tea organizes survival rate in a large number obviously increases, difference has significant (P < 0.05).
3, Summertime tea is on the impact of learning and memory of little mouse
Memory acquisition disturbance model mice learning and memory is affected
The results are shown in Table 8.
Table 8 Summertime tea on memory acquisition disturbance model mice learning and memory impact (
n=10)
With normal group ratio, * P < 0.05; With model group ratio, #P < 0.05
From table 8, compare with Normal group, obviously reduce through the incubation period of the model group mouse of hyoscine process, errors number significantly increases, and difference has significant (P < 0.05).Compare with model group, the incubation period of each administration group mouse of successive administration after 10 days is all prolongation in various degree, errors number reduces to some extent, and wherein middle dosage group, in a large number the group difference of piracetam group, Summertime tea all have significant (P < 0.05).
Four, experiment conclusion
Health food Summertime tea rat of the present invention by 0.7,1.4,2.8g particle/kg, mouse by 1.11,3.32,9.45g particle/kg gastric infusion, significantly can improve Model of Acute Myocardial Ischemia Rat Ecg ST field offset, reduce serum CK, LDH vigor, reduce myocardial infarction weight, have certain effect protective effect to the pathological change of cardiac muscular tissue; Significantly improve the incubation period of memory acquisition disturbance model mice step down test and reduce errors number; There is prolongation trend to the time-to-live of mouse under hot conditions, obviously increase the survival rate of mouse.Result shows, Summertime tea has protective effect to acute myocardial ischemia, can obviously improve acquired memory, and have high temperature resistant effect.
Following embodiment all can realize the effect of above-mentioned experimental example.
embodiment 1granule
Radix polygonati officinalis 2.67kg north stilbene 2kg wild jujube 2kg root of kudzu vine 1.33kg
Pawpaw 1.33kg honeysuckle 0.33kg green tea 0.34kg
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, adds dextrin 7.55kg and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; Add dolomol 0.05kg to mix, obtain health food granule 10kg of the present invention, pack, 5g/ bag, to obtain final product.
embodiment 2capsule
Radix polygonati officinalis 1335g north stilbene 1000g wild jujube 1000g root of kudzu vine 665g
Pawpaw 665g honeysuckle 165g green tea 170g
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, adds dextrin 3775g and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; Add dolomol 25g to mix, conventionally add customary adjuvant and make capsule.
embodiment 3 tablet
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, and the dextrin adding its weight 3 times mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; The dolomol adding its weight 20% mixes, and calculate sheet weight, compressing tablet, or dressing, to obtain final product.
embodiment 4pill
Radix polygonati officinalis 1335g north stilbene 1000g wild jujube 1000g root of kudzu vine 665g
Pawpaw 665g honeysuckle 165g green tea 170g
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, adds dextrin 3775g and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; Add dolomol 25g to mix, conventionally add customary adjuvant and make pill.
embodiment 5supensoid agent
Radix polygonati officinalis 2.67kg north stilbene 2kg wild jujube 2kg root of kudzu vine 1.33kg
Pawpaw 1.33kg honeysuckle 0.33kg green tea 0.34kg
Get bulk drug routinely technique add customary adjuvant and make supensoid agent.
embodiment 6dripping pill
Get bulk drug routinely technique add customary adjuvant and make dripping pill.
embodiment 7oral liquid
Get bulk drug routinely technique add customary adjuvant and make oral liquid.
embodiment 8:the preparation of health food extract of the present invention
Radix polygonati officinalis 2.67kg north stilbene 2kg wild jujube 2kg root of kudzu vine 1.33kg
Pawpaw 1.33kg honeysuckle 0.33kg green tea 0.34kg
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, drying under reduced pressure under DEG C condition of temperature≤70, get dry extract, be ground into fine powder.
embodiment 9:the preparation of health food extract of the present invention
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, drying under reduced pressure under DEG C condition of temperature≤70, get dry extract, be ground into fine powder.
embodiment 10:the preparation of health food extract of the present invention
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, drying under reduced pressure under DEG C condition of temperature≤70, get dry extract, be ground into fine powder.
embodiment 11granule
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, adds dextrin 7.55kg and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; Add dolomol 0.05kg to mix, obtain health food granule 10kg of the present invention, pack, 5g/ bag, to obtain final product.
embodiment 12granule
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, adds dextrin 7.55kg and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; Add dolomol 0.05kg to mix, obtain health food granule 10kg of the present invention, pack, 5g/ bag, to obtain final product.
Claims (10)
1., for treating a health food for myocardial ischemia, Improving memory power and raising heat-resisting ability summer, it is characterized in that this food is made up of following raw material medicaments:
Radix polygonati officinalis 15-35 weight portion north stilbene 10-30 weight portion
Wild jujube 10-30 weight portion root of kudzu vine 8-18 weight portion
Pawpaw 8-18 weight portion honeysuckle 1-6 weight portion
Green tea 1-5 weight portion.
2. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
Radix polygonati officinalis 26.7 weight portion north stilbene 20 weight portion
The wild jujube 20 weight portion root of kudzu vine 13.3 weight portion
Pawpaw 13.3 weight portion honeysuckle 3.3 weight portion
Green tea 3.4 weight portion.
3. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
Radix polygonati officinalis 32 weight portion north stilbene 12 weight portion
The wild jujube 12 weight portion root of kudzu vine 16 weight portion
Pawpaw 16 weight portion honeysuckle 2 weight portion
Green tea 2 weight portion.
4. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
Radix polygonati officinalis 18 weight portion north stilbene 28 weight portion
The wild jujube 28 weight portion root of kudzu vine 10 weight portion
Pawpaw 10 weight portion honeysuckle 5 weight portion
Green tea 4 weight portion.
5. the health food as described in as arbitrary in claim 1-4, is characterized in that getting this healthy food material medicine and adds customary adjuvant and conventionally prepare one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
6. the preparation method of the health food as described in as arbitrary in claim 1-4, is characterized in that the method is:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 1-3 hour, decoct and extract 2-4 time, each 0.5-1.5 hour, amount of water is 6-12 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.01 ~ 1.10, for subsequent use; Get shitosan, add 1% acetum of 80-120 times of weight, be heated to 30-60 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3%-4%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.20 ~ 1.40, and drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder.
7. the preparation method of health food as claimed in claim 6, is characterized in that the method is:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, and drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder.
8. the preparation method of the health food as described in as arbitrary in claim 1-4, is characterized in that the method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 1-3 hour, decoct and extract 2-4 time, each 0.5-1.5 hour, amount of water is 6-12 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.01 ~ 1.10, for subsequent use; Get shitosan, add 1% acetum of 80-120 times of weight, be heated to 30-60 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3%-4%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.20 ~ 1.40, adds its weight 2-4 dextrin doubly and mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; The dolomol adding its weight 15%-25% mixes, and adds customary adjuvant and conventionally makes one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
9. the preparation method of health food as claimed in claim 8, is characterized in that the method:
Get radix polygonati officinalis, northern stilbene, wild jujube, the root of kudzu vine, pawpaw, honeysuckle, green tea, soak 2 hours, decoct extraction 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filters, merging filtrate, when being evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate A of 1.02 ~ 1.04, for subsequent use; Get shitosan, add 1% acetum of 100 times of weight, be heated to 40 ~ 50 DEG C, be stirred to dissolve, obtain chitosan solution; In concentrate A, add the chitosan solution of its weight 3.6%, stir and evenly mix, hold over night, filter, when filtrate is evaporated to 60 DEG C under DEG C condition of temperature≤70, relative density is the concentrate B of 1.25 ~ 1.30, and the dextrin adding its weight 3 times mixes, drying under reduced pressure under DEG C condition of temperature≤70, dried cream powder is broken into fine powder, add 95% ethanol and make softwood, 14 mesh sieves are granulated, dry under DEG C condition of temperature≤70, the whole grain of 12 mesh sieve, obtains particle; The dolomol adding its weight 20% mixes, and adds customary adjuvant and conventionally makes one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
10. the health food as described in as arbitrary in claim 1-4 is in the application for the treatment of myocardial ischemia, Improving memory power for the preparation of summer and improve in the health food of heat-resisting ability.
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