CN103168919A - Feed additive for enhancing immunity and promoting growth and feed - Google Patents
Feed additive for enhancing immunity and promoting growth and feed Download PDFInfo
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- CN103168919A CN103168919A CN2013101176603A CN201310117660A CN103168919A CN 103168919 A CN103168919 A CN 103168919A CN 2013101176603 A CN2013101176603 A CN 2013101176603A CN 201310117660 A CN201310117660 A CN 201310117660A CN 103168919 A CN103168919 A CN 103168919A
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Abstract
The invention discloses a feed additive for enhancing immunity and promoting growth. The feed additive consists of the following components in parts by weight: 12-30 parts of astragalus, 12-20 parts of rhizoma ligustici wallichii, 10-20 parts of angelica, 10-20 parts of radix paeoniae alba, 10-20 parts of geranium strictipes, 12-30 parts of pomegranate peel, 10-15 parts of saposhnikovia divaricata, 8-15 parts of tangerine peel, 8-15 parts of fructus schisandrae and 8-15 parts of hawthorn. The feed additive is reasonable in formula, and has the efficacies of strengthening healthy qi to eliminate pathogens, tonifying qi and strengthening exterior, invigorating spleen and appetizing, resolving food stagnation, replenishing blood and engendering liquid, and the like. The feed additive disclosed by the invention can be directly added into feed and used for enhancing immunity and promoting growth of poultry after feeding so as to improve the production effectiveness of the poultry.
Description
Technical field
The invention belongs to feed additive field, relate to a kind of feed addictive that strengthens immunity and promote growth, also relate to the feed that contains feed addictive.
Background technology
Along with socioeconomic fast development, the livestock and poultry cultivation intensive degree is more and more higher.In modernization intensive culture process, the prevention and control situation of disease, the number of animals raised, survival rate and the price of deed of poultry are the main sources of culture benefit.The culturist has taked the raising stocking density for this reason, feed high nutrient fodder, long-term add in feed antibiotic and chemicals prevent epidemic disease, frequently use disinfectant, improve the measures such as breeding environment of poultry, make poultry be in high-intensity antibiotic and chemicals pressure and high load capacity, height stress the physiology critical condition.In this state, epidemic disease very easily occurs in poultry, reduces on the contrary production performance, causes simultaneously the medicament residue of the goods such as meat, egg, and human health has been consisted of great threat.
Increase stocking density and frequently use disinfectant easily to cause stress reaction, environment disturbance in poultry, immunity reduces; The high nutrient fodder of feeding easily causes higher digestion and metabolism burden; Heavy dose of, use antibiotic and chemicals to be added into the feed diseases prevention for a long time, usually damage stomach Qi, cause feed intake and descend, and cause the generation of cause of disease drug resistance and medicament residue, cause that even the liver drug metabolic is poisoning.Therefore, necessary research can strengthen body immunity, improve the taste function, can reduce or eliminate drug resistance and medicament residue again, improve poultry defending and fighting against diseases, somatotrophic feed addictive.
Summary of the invention
In view of this, one of purpose of the present invention is to provide feed addictive, and its formula rationally can strengthen the immunity of poultry, simultaneously growth promotion; Two of purpose of the present invention is to provide the feed that contains feed addictive.
For achieving the above object, technical scheme is:
1. feed addictive that strengthens immunity and promote growth, composed of the following components by weight: Radix Astragali 12-30 part, Ligusticum wallichii 12-20 part, Radix Angelicae Sinensis 10-20 part, root of herbaceous peony 10-20 part, mountain on the other way round disappear 10-20 part, granatum 12-30 part, windproof 10-15 part, dried orange peel 8-15 part, fruit of Chinese magnoliavine 8-15 part and hawthorn 8-15 part.
Preferably, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of Ligusticum wallichiis, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, mountain on the other way round disappear 8 parts of 10 parts, 12 parts of granatums, windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine and hawthorn.
In the present invention, the effect of each component is as follows:
The Radix Astragali has another name called yellow over sixty years of age, is the general designation of plant and Chinese medicine.The Chinese medicine Radix Astragali is the root of leguminous herbaceous plant's astragalus mongolicus, Astragalus membranacus, has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.
Ligusticum wallichii be the samphire Ligusticum wallichii (
Ligusticum chuanxiong Hort.) rhizome; Warm in nature, hot, return liver, courage, the heart channel of Hang-Shaoyin, cure mainly blood-activating and qi-promoting, wind-expelling pain-stopping.
When be classified as umbelliferae angelica (
Angelica sinensis(Oliv.) Diels) root.Warm in nature, distinguish the flavor of sweet, hot; Return liver, the heart, the spleen channel; Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving and the effect that relaxes bowel, is used for sallow, the dizzy palpitaition of the deficiency of blood, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores etc.
The root of herbaceous peony be Ranunculaceae Paeonia plant RADIX PAEONIAE ALBA (
Paeonia sterniana Fletcher in Journ.) root.Bitter acid, cool, have nourishing blood and liver, slow middle pain relieving, astringe yin is received the effect of sweat; Cure mainly chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, inferior symptom is with in uterine bleeding.
Dried orange peel be rutaceae orange (
Citrus reticulata Blanco) and the maturate peel of variety, have the effect that the appetizing of regulating the flow of vital energy is eliminating dampness and eliminating phlegm, control the spleen-stomach diseases.
The fruit of Chinese magnoliavine be perennial fallen leaves liana magnoliaceae schisandra (
Schisandra chinensis (Turcz.) Baill.) or schisandra chinensis (
Schisandra sphenantheraRehd.etWils.) dry mature fruit.Has convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, the effect of kidney calming.
Windproof be the Umbelliferae herbaceos perennial windproof (
Saposhnikovia divaricata (Turcz.) Schischk.) dry root; Flavor is hot, sweet, slightly warm in nature; Return bladder, liver, the spleen channel; Have expel pathogenic wind from the body surface, removing dampness to relieve pain and the convulsion effect of surely jerking only, cure mainly the diseases caused by external factors illness that has not attacked the vital organs of the human body, rubella itch, arthralgia due to wind-dampness, lockjaw.
The mountain on the other way round disappear for dicotyledon Asclepiadaceae cynanchum auriculatum Royle (
Cynanchumauriculatum rayleex Wight) the piece root; Has filling liver kidney; Strengthening the bones and muscles; Strengthening the spleen and stomach; The effects such as detoxifcation.
Granatum be Punicaceae plant pomegranate (
Punica granatum L.) dry pericarp; Sour and astringent, temperature, poisonous; Enter large intestine, kidney channel; Have puckery intestines, hemostasis, insect-expelling function.
Hawthorn be the rosaceous plant large-fruited Chinese hawthorn (
Crataegus pinnatifida Bge. var. major N. E. Br.) or hawthorn (
Crataegus pinnatifida Bge.) dry mature fruit, distinguish the flavor of sweet, sour, slightly warm in nature; Enter spleen, stomach, Liver Channel; Cure mainly food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of faling apart.
2. the feed that contains described feed addictive.
Preferably, in described feed, the percentage by weight of feed addictive is 0.5-1%.
Preferred, in described feed, the percentage by weight of feed addictive is 0.75%.
Beneficial effect of the present invention is: feed addictive disclosed by the invention, formula rationally, physilogical characteristics according to poultry, take into full account the combination principle of eighteen incompatibilities and the nineteen counteraction of Chinese medicine, press the principles of formulating prescriptions of the monarch of Chinese medicine, adopt length after the mutual compatibility of each component and mend short, collaborative formed mutually; In formula with Radix Astragali invigorating qi for strengthening superficies, windproof expelling pathogenic wind from the body surface, Chinese angelica blood supplementing is invigorated blood circulation, the Ligusticum wallichii blood-activating and qi-promoting, root of herbaceous peony nourishing blood and liver, astringe yin are received sweat, mountain on the other way round disappear kidney tonifying, invigorating the spleen, astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of fruit of Chinese magnoliavine convergence, the puckery intestines of granatum, expelling parasite, the dried orange peel appetizing of regulating the flow of vital energy, hawthorn digesting stomach invigorating, the loose stasis of blood of promoting the circulation of qi, all medicine phases 5 are to reach the effect of strengthening vital QI to eliminate pathogenic factors, invigorating qi for consolidating superficies, spleen benefiting and stimulating the appetite, promoting digestion and removing indigestion, enriching blood and promoting secretion of body fluid; By modern veterinary viewpoint, livestock fodder additives disclosed by the invention can strengthen the immunologic function of animal body, improves the utilization ratio of feed and promotes the effect that poultry grows; Simultaneously, livestock fodder additives disclosed by the invention uses Chinese medicine preparation, can avoid the generation of cause of disease drug resistance, reduces chemicals residual, improves the productivity effect of poultry.
Description of drawings
Fig. 1 is that feed addictive is to colibacillary fungistatic effect.
Fig. 2 is that feed addictive is to the fungistatic effect of salmonella.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
Embodiment 1
A kind of feed addictive that strengthens immunity and promote growth, composed of the following components by weight: 22 parts of the Radixs Astragali, 16 parts of Ligusticum wallichiis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of herbaceous peonys, mountain on the other way round disappear 15 parts, windproof 15 parts, 12 parts of dried orange peels, 12 parts, the fruit of Chinese magnoliavine, 16 parts of 12 parts of hawthorn and granatums.
Add in pulverizer respectively and pulverize for the ease of absorbing feed addictive with above-mentioned formula, after mixing, cross 80 mesh sieves, then save backup.
The preparation method of poultry feed: feed addictive is added in poultry feed, and the weight ratio that adds rear feed addictive is 0.5%.
Embodiment 2
A kind of feed addictive that strengthens immunity and promote growth, composed of the following components by weight: 30 parts of the Radixs Astragali, 20 parts of Ligusticum wallichiis, 20 parts of Radix Angelicae Sinensis, 20 parts of the root of herbaceous peonys, mountain on the other way round disappear 20 parts, windproof 13 parts, 15 parts of dried orange peels, 15 parts, the fruit of Chinese magnoliavine, 30 parts of 15 parts of hawthorn and granatums.
Add in pulverizer respectively and pulverize for the ease of absorbing feed addictive with above-mentioned formula, after mixing, cross 60 mesh sieves, then save backup.
The preparation method of poultry feed: feed addictive is added in poultry feed, and the weight ratio that adds rear feed addictive is 1%.
Embodiment 3
A kind of feed addictive that strengthens immunity and promote growth, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of rhizomes of chuanxiong, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, the mountain on the other way round disappears 10 parts, and windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine, 12 parts of 8 parts of hawthorn and granatums.
The feed addictive of above-mentioned formula is added in pulverizer respectively pulverize, after mixing, cross 100 mesh sieves, then save backup.
For the preparation of poultry feed, its preparation method is with feed addictive: feed addictive is added in the normal poultry feed, and the weight ratio that adds rear feed addictive is 0.75%.
Embodiment 4
The bacteriostatic test of the feed addictive of embodiment 1 ~ 3 formula:
Feed addictive is prepared into water extraction liquid, concrete grammar is: feed addictive (mixture after the pulverizing) 100g that gets respectively embodiment 1, embodiment 2 and embodiment 3, then add the distilled water immersion 40 minutes that is equivalent to 10 times of feed addictive weight, with slow fire boiling 30 minutes, then use 8 layers of filtered through gauze after boiling; The dregs of a decoction add the distilled water that is equivalent to 10 times of feed addictive weight again and use slow fire boiling 30 minutes, then use 8 layers of filtered through gauze; Merge 2 times filtrate, be concentrated in liquid crude drug content as 1 g/mL take slow fire, 120 ℃ of autoclavings 20 minutes, 4 ℃ of Refrigerator stores are standby.
The preparation of the antibacterial scraps of paper: with card punch, filter paper is broken into the disk of diameter 6 mm, put 100 in each bottle, 140 ℃ of hot air sterilizations 2 hours.The liquid of getting crude drug content that 1 mL prepared and be 1 g/mL adds in the bottle that 100 drug sensitive test papers are housed, simultaneously the drug sensitive test paper of sterilizing is added the butylamine kalamycin of 1 mL concentration 100mg/mL in contrast, soaking at room temperature 2 hours, dry with the culture dish seasoning, 4 ℃ of Refrigerator stores are standby.
extracorporeal bacteria inhibitor test: enteropathogenic E.Coli and the salmonella ordinary broth culture of getting respectively clinical separation, evenly coat nutrient agar panel (peptone 1%, beef extract 0.3%, sodium chloride 0.5%, agar 1.5% ~ 2.0%, the distilled water preparation, pH 7.2 ~ 7.4) on, each flat board is done 5 repetitions, cultivated 24 hours for 37 ℃, then with embodiment 1, the water extraction liquid of the formula preparation of embodiment 2 and embodiment 3 and butylamine kalamycin are to the antibacterial result of Escherichia coli as shown in Figure 1, to the antibacterial result of salmonella as shown in Figure 2, then suppress the bacterium loop diameter according to antibacterial outcome measurement, measurement result is antibacterial the results are shown in Table 1.
Criterion: antibacterial circle diameter 〉=19 mm are extremely sensitive; 14-19 mm is medium sensitivity; 10-14 mm is low responsive; ≤ 10 mm are resistance.
The bacteriostatic test of the water extraction liquid of table 1, feed addictive
As shown in Table 1, the water extraction liquid of the feed addictive of embodiment 1, embodiment 2 and embodiment 3 preparation all has certain bacteriostasis to enteropathogenic E.Coli and salmonella, and wherein the water extraction liquid of embodiment 2 and embodiment 3 preparations has medium fungistatic effect.Therefore, feed addictive disclosed by the invention has the function of the growth and breeding that suppresses pathogenic.
Experimental example 5
The impact of feed addictive disclosed by the invention on Sichuan White Goose production performance and Development of Immune Organs, concrete grammar is:
(1) animal and basal diet: choose 240 of certain same batch of field of goose healthy and strong young geese on the 1st of Sichuan.The experimental basis daily ration forms " supporting goose the produces complete works of " preparation of writing with reference to Wang Zhiyue, and the percentage by weight of each component is: corn 57.1%, wheat 6.0%, wheat bran 5.8%, dregs of beans 17.3%, peanut cake 2.5%, rapeseed cake 1.5%, fish meal 5.0%, calcium monohydrogen phosphate 1.4%, stone flour 1.2%, salt 0.3%, premix 1.0%, lysine 0.05%, methionine 0.2%, carnitine 0.15%.
(2) test grouping with process: 240 young geese are divided into 4 groups at random, and 60 every group, then 3 repetitions are set with every group, each repeats 20 young geese.The I group is the blank group: the basal diet of feeding; The II group is processed group 1: the basal diet that contains embodiment 1 feed addictive of the same amount of feeding, feed addictive account for the 1.0%(mass fraction of basal diet); The III group is processed group 2, and the basal diet that contains embodiment 2 feed addictives of the same amount of feeding, feed addictive account for the 1.0%(mass fraction of basal diet); The IV group is processed group 3: the basal diet that contains embodiment 3 feed addictives of the same amount of feeding, feed addictive account for the 1.0%(mass fraction of feed addictive).Brood time adopts drylot feeding and adds bedding and padding, and the 1st all temperature are controlled at 28-30 ℃, descend weekly later on 2 ℃.The young goose of each test group greenfeed with the weight such as blank group basal diet of feeding is fed 6 times on (50 grams-200 gram/every plumage, basal diet and greenfeed are the ratio mixed feeding of 1:2 by weight) every day, allows young goose freely drink cold boiling water.
(3) test index and method: from on-test every 1 week (1,7,14 and 21 age in days), to repeat to calculate into the empty stomach body weight of the young goose of unit weighing average weight and the daily gain of young goose in each group, observe the health condition of young goose every day, record dead quantity, be calculated to be motility rate, result is as shown in table 2.
The impact on production performance of table 2, feed addictive
As shown in Table 2, the young goose of the feed addictive that contains embodiment 1, embodiment 2 and embodiment 3 fed is compared daily gain and improves 5.7%, 8.2% and 11.3% with the blank group, survival rate is also higher than the blank group, and therefore feed addictive disclosed by the invention can improve survival rate and the average daily gain of young goose.
During 21 age in days, randomly draw 3 young geese from each repeats, weigh on an empty stomach, the neck bloodletting is lethal, wins spleen, thymus gland and the bursa of farbricius and weighs, and namely the adaptive immune organ weight, calculate Immune Organs Index, and result is as shown in table 3.
The computing formula of Immune Organs Index is as follows: Immune Organs Index=immune organ heavy (mg)/empty stomach body weight (g).
The impact on Immune Organs Index of table 3, feed addictive
Group | Thymus index | Bursa of farbricius index | Index and spleen index |
The blank group | 3.97±0.14 | 3.85±1.01 | 2.02±0.13 |
Processed group 1 | 4.02±0.09 | 4.16±0.52 | 2.18±0.07 |
Processed group 2 | 4.15±0.18 | 4.31±0.60 | 2.31±0.20 |
Processed group 3 | 4.06±0.03 | 4.28±0.35 | 2.17±0.05 |
As shown in Table 3, the Immune Organs Index of the young goose of the feed addictive that contains embodiment 1, embodiment 2 and embodiment 3 of feeding illustrates that all higher than the blank group feed addictive disclosed by the invention can promote the growth of young goose immune organ.
Experimental example 6
The impact of feed addictive of the present invention on Luo Man growth performance of chicks and immune level, concrete grammar is:
(1) animal and basal diet: choose 300 of 1 age in days Luo Man chick.The experimental basis daily ration needs (the 9th revised edition) preparation with reference to poultry nutrition, is for the percentage by weight of component: corn 60.1%, dregs of beans 24 %, wheat bran 9.5%, fish meal 2.5%, lysine 0.1%, methionine 0.15%, stone flour 1.4%, calcium monohydrogen phosphate 1.35%, salt 0.3%, multidimensional 0.2%, mineral matter 0.3%, 50% Choline Chloride 0.1%.
(2) test grouping and processing: during 7 age in days, remove excessive and too small weak chick, select 240 healthy chicks to be divided at random 4 groups, 60 every group, then each group arranges in 3 groups and repeats, and each repeats 20 young geese.The I group is the blank group, the basal diet of feeding; The II group is fed and is contained the basal diet of embodiment 1 feed addictive, and the percentage by weight of feed addictive is 1.0 %; The III group is fed and is contained the basal diet of embodiment 2 feed addictives, and the percentage by weight of feed addictive is 1.0 %; The IV group is fed and is contained the basal diet of embodiment 3 feed addictives, and the percentage by weight of feed addictive is 1.0 %.The test breeding chickling is in the wire mesh cage of flame disinfection, and the corresponding group feed of feeding is fed 6 times (basal diet and greenfeed are by weight being the 1:2 mixed feeding, and scale of feeding is 50 grams-200 gram/every plumage), and allow chick freely drink cold boiling water every day.Grouping was chosen 3 chick at random at every group of same day, and ewcastle disease HI antibody titer is measured in the heart blood sampling.Be that seedling carries out eye droppings and collunarium to all test chickens with the ewcastle disease IV simultaneously, measured the antibody titer of ewcastle disease in immunity in rear 15 days.After immunity 15 days, randomly draw 3 chickens for every group, heart blood sampling, separation of serum, then with the tiring of β-microdetermination newcastle epidemic disease antibody, result is as shown in table 4.
Table 4, feed addictive detect to Luo Man chicken Newcastle disease immune antiboidy tire (log2)
Group | 7 ages in days | 22 ages in days | Improve (%) than blank group |
The blank group | 3.4±0.25 | 6.5±0.20 | — |
1 group, Chinese medicine | 3.6±0.49 | 6.9±0.55 | 6.16 |
2 groups, Chinese medicine | 3.4±0.32 | 7.0±0.40 | 7.69 |
3 groups, Chinese medicine | 3.5±0.37 | 7.2±0.92 | 10.77 |
As can be seen from Table 4, feed and contain the chick of embodiment 1, embodiment 2 and embodiment 3 feed addictives, antibody titer of ND improves 6.16%, 7.69% and 10.77% than blank group, illustrate that Chinese medicine of the present invention can obviously improve ND Vaccine immune antiboidy level, has immunological enhancement.
Production performance test: from on-test every 1 week (7,14,21 and 28 age in days), to repeat to calculate into the empty stomach body weight of unit weighing chick average weight and the daily gain of chick in each group, observe the health condition of chick every day, record dead quantity, be calculated to be motility rate, the results are shown in Table shown in 5.
The impact on Luo Man chick production performance of table 5, feed addictive
During 28 age in days, randomly draw 3 chick from each repeats, weigh on an empty stomach, the neck bloodletting is lethal, wins spleen, thymus gland and the bursa of farbricius and weighs, and namely gets immune organ heavy, then calculates Immune Organs Index, the results are shown in Table shown in 6.
Heavy (the mg)/live body of Immune Organs Index=immune organ heavy (g).
The impact on the Luo Man Immune Organs Index of Chicks of table 6, feed addictive
Group | Thymus index | Bursa of farbricius index | Index and spleen index |
The blank group | 3.34±0.31 | 3.43±0.92 | 2.17±0.27 |
1 group, Chinese medicine | 3.60±0.44 | 3.47±0.66 | 2.29±0.24 |
2 groups, Chinese medicine | 3.92±0.36 | 3.65±0.55 | 3.09±1.01 |
3 groups, Chinese medicine | 3.84±0.72 | 4.02±1.17 | 3.13±1.48 |
By table 5-6 as can be known, the chick that contains embodiment 1, embodiment 2 and embodiment 3 feed addictives fed is compared daily gain with the blank group and improves respectively 3.7%, 6.5% and 7.5%, and the Immune Organs Index of three groups of chick is all higher than the blank group, illustrate that Chinese medicine of the present invention can improve survival rate and the daily gain of chick, promote the growth of immune organs of chicken treated.
Explanation is at last, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can make various changes to it in the form and details, and not depart from claims limited range of the present invention.
Claims (5)
1. one kind strengthens immunity and the feed addictive that promotes growth, it is characterized in that, composed of the following components by weight: Radix Astragali 12-30 part, Ligusticum wallichii 12-20 part, Radix Angelicae Sinensis 10-20 part, root of herbaceous peony 10-20 part, mountain on the other way round disappear 10-20 part, granatum 12-30 part, windproof 10-15 part, dried orange peel 8-15 part, fruit of Chinese magnoliavine 8-15 part and hawthorn 8-15 part.
2. feed addictive according to claim 1, it is characterized in that, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of Ligusticum wallichiis, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, mountain on the other way round disappear 8 parts of 10 parts, 12 parts of granatums, windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine and hawthorn.
3. the feed that contains claim 1 or 2 described feed addictive.
4. feed according to claim 3, it is characterized in that: in described feed, the percentage by weight of feed addictive is 0.5-1%.
5. feed according to claim 4, it is characterized in that: in described feed, the percentage by weight of feed addictive is 0.75%.
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