CN103132163B - A kind of preparation method with the fiber of multi-kernel shell structure - Google Patents
A kind of preparation method with the fiber of multi-kernel shell structure Download PDFInfo
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- CN103132163B CN103132163B CN201310077495.3A CN201310077495A CN103132163B CN 103132163 B CN103132163 B CN 103132163B CN 201310077495 A CN201310077495 A CN 201310077495A CN 103132163 B CN103132163 B CN 103132163B
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Abstract
The invention discloses a kind of fiber with multi-kernel shell structure, described fiber has multi-kernel shell structure, the diameter of described fiber be 10 microns to 1 × 10
6micron, length is more than 1 millimeter, and the cross section of described fiber is circular or hollow ring; And the preparation method of described fiber.By the way, the pattern of fiber of the present invention and structure-controllable, designability and the practicality of preparation method's simple operation, fiber are stronger, can realize the parcel of nano particle of different nature, medicine or active somatic cell, this fiber can be applied in the fields such as cell chulture, medicament slow release, organizational project.
Description
Technical field
The present invention relates to technical field of biological materials, particularly relate to and a kind of there is fiber of multi-kernel shell structure and preparation method thereof.
Background technology
Fiber refers to the material be made up of continuous or discrete filament.Just there is natural fiber in occurring in nature, just can directly obtain from plant, animal and Minerals And Rocks, as flax, jute, wool, the rabbit hair, mineral fibres etc., visible everywhere in daily life.Relative to natural fabric, chemical fibre is a kind of fiber processed through chemical treatment, more than wide, the kind of its raw material, is all widely used in high-tech areas such as textile industry, military affairs, environmental protection, medicine, building, biotechnologies.Along with the development of science and technology, the needs of people to the 26S Proteasome Structure and Function of fiber are increasing, are no longer confined to the fiber of one-component, homogenous material, simple function, and the preparation of composite fibre seems particularly important.And traditional preparation method, as melt spinning, wet spinning, electrostatic spinning etc., due to the restriction of its technique and principle, the fiber preparation with labyrinth and function encounters difficulty.Especially at biological technical field, fiber, as the three-dimensional carrier of cell chulture, synchronously completes the parcel of cell and the preparation of fiber under guarantee does not destroy the prerequisite of cytoactive, and traditional preparation method is difficult to realize.
Micro-fluidicly refer to the technology that one accurately manipulates minute yardstick (especially submicron-scale) fluid, have that device volume is little, liquid flow is controlled, consume sample and amount of reagent is less, be easy to manipulation, not easily cause the advantages such as cross pollution.Utilize the micro-channel device of microflow control technique, can controllably prepare various shape, structure functional vector, the encapsulation of chemistry of different nature, biological sample can also be realized, be widely used in genomics, proteomics, combinatorial chemistry, drug screening and slowly-releasing, cell chulture and clinical diagnosis field.
Therefore, utilizing microflow control technique to be the composite fibre that preparation has labyrinth and a function is the powerful measure solved the problem.
Summary of the invention
The object of the invention is the fiber and the method thereof that provide a kind of multi-kernel shell structure, and its preparation process is simple, and appearance and size is controlled, favorable repeatability.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: provide a kind of fiber with multi-kernel shell structure, described fiber has multi-kernel shell structure, the diameter of described fiber be 10 microns to 1 × 10
6micron, length is more than 1 millimeter, and the cross section of described fiber is circular or hollow ring.
In a preferred embodiment of the present invention, the volume of described each nucleocapsid is identical.
In a preferred embodiment of the present invention, the volume of described each nucleocapsid is not identical.
For solving the problems of the technologies described above, another technical solution used in the present invention is: the method providing the fiber described in a kind of preparation with multi-kernel shell structure, and described fiber is by the preparation of micro-fluidic method, comprises the following steps:
First, micro-fluidic chip build step:
Adopt micro-processing technology to set up microfluidic channel network, or select capillary glass tube, sheet glass and syringe needle to set up microfluid c-axial channel network, this channel network comprises three kinds of passages, is respectively fluid passage, continuous phase passage and co-flow pathway;
Secondly, the preparation process of fiber:
Fluid-phase solution and continuous phase solution are respectively charged into syringe, connect respective entrance, control each phase solution flow rate with numerical control syringe pump, treat that decentralized photo presents stable threadiness in co-flow pathway, curing is, is cured the fluid liquid that mixes by physico-chemical process.
In a preferred embodiment of the present invention, described microfluidic channel network adopts silicon, glass, polymethyl methacrylate or dimethyl silicone polymer micro-fluid chip to make, the internal diameter size of passage be 1 micron to 1 × 10
6micron.
In a preferred embodiment of the present invention, according to the nucleocapsid number of plies of described fiber, described fluid passage is one or more, and multiple decentralized photo passage independently of one another and coaxial nested layer by layer from inside to outside.
In a preferred embodiment of the present invention, described fluid-phase solution be selected from calcium alginate, agarose, shitosan, acrylic acid, acrylamide, N-isopropylacrylamide, polyethyleneglycol diacrylate, Ethylene glycol dimethacrylate, methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxanes methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol or glycidyl methacrylate one or more.
In a preferred embodiment of the present invention, described fluid-phase solution is oil-soluble, described continuous phase solution be selected from methyl-silicone oil, hexadecane, paraffin oil or soybean oil one or more.
In a preferred embodiment of the present invention, described fluid-phase solution is water-soluble, described continuous phase solution be selected from water, ethanol, polyvinyl alcohol, polyethylene glycol, glycerine, calcium ion salts solution, magnesium ion salting liquid or barium ions salting liquid one or more.
In a preferred embodiment of the present invention, the curing of described fiber select in thermal curing method, ultraviolet curing method or ion exchange method one or more.
The invention has the beneficial effects as follows: the pattern of fiber of the present invention and structure-controllable, the designability of preparation method's simple operation, fiber and practicality are stronger, can realize the parcel of nano particle of different nature, medicine or active somatic cell.
Accompanying drawing explanation
Fig. 1 is that the present invention prepares microfluidic channel network schematic diagram in the fiber process with multi-kernel shell structure;
Fig. 2 is the schematic diagram that the present invention has the fiber of multi-kernel shell structure;
In accompanying drawing, the mark of each parts is as follows: 1, co-flow pathway; 2, continuous phase passage; 3, fluid passage; 4, fiber.
Detailed description of the invention
Below in conjunction with accompanying drawing, preferred embodiment of the present invention is described in detail, can be easier to make advantages and features of the invention be readily appreciated by one skilled in the art, thus more explicit defining is made to protection scope of the present invention.
Refer to Fig. 1 and Fig. 2, the embodiment of the present invention provides following technical scheme
In one embodiment, a kind of fiber 4 with multi-kernel shell structure, described fiber 4 has multi-kernel shell structure, the diameter of described fiber 4 be 10 microns to 1 × 10
6micron, length is more than 1 millimeter, and the cross section of described fiber 4 is circular or hollow ring.
Preferably, the volume of described each nucleocapsid is identical.
Preferably, the volume of described each nucleocapsid is not identical.
For solving the problems of the technologies described above, another technical solution used in the present invention is: the method providing the fiber 4 described in a kind of preparation with multi-kernel shell structure, and described fiber 4 is by the preparation of micro-fluidic method, comprises the following steps:
First, micro-fluidic chip build step:
Adopt micro-processing technology to set up microfluidic channel network, or select capillary glass tube, sheet glass and syringe needle to set up microfluid c-axial channel network, this channel network comprises three kinds of passages, is respectively fluid passage 3, continuous phase passage 2 and co-flow pathway 1;
Secondly, the preparation process of fiber:
Fluid-phase solution and continuous phase solution are respectively charged into syringe, connect respective entrance, control each phase solution flow rate with numerical control syringe pump, treat that decentralized photo presents stable threadiness in co-flow pathway 1, curing is, is cured the fluid liquid that mixes by physico-chemical process.
Preferably, described microfluidic channel 3 network adopts silicon, glass, polymethyl methacrylate or dimethyl silicone polymer micro-fluid chip to make, the internal diameter size of passage be 1 micron to 1 × 10
6micron.
Preferably, according to the nucleocapsid number of plies of described fiber 4, described fluid passage 3 is one or more, and multiple decentralized photo passage independently of one another and coaxial nested layer by layer from inside to outside.
Preferably, described fluid-phase solution is selected from one or more in calcium alginate, agarose, shitosan, acrylic acid, acrylamide, N-isopropylacrylamide, polyethyleneglycol diacrylate, Ethylene glycol dimethacrylate, methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxanes methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol or glycidyl methacrylate.
Preferably, described fluid-phase solution is oil-soluble, described continuous phase solution be selected from methyl-silicone oil, hexadecane, paraffin oil or soybean oil one or more.
Preferably, described fluid-phase solution is water-soluble, described continuous phase solution be selected from water, ethanol, polyvinyl alcohol, polyethylene glycol, glycerine, calcium ion salts solution, magnesium ion salting liquid or barium ions salting liquid one or more.
Preferably, the curing of described fiber 4 selects one or more in thermal curing method, ultraviolet curing method or ion exchange method.
The present invention utilizes microflow control technique, according to the 26S Proteasome Structure and Function of multicomponent fibre, designs and builds micro-fluidic chip, by regulating composition and the flow velocity of each phase solution, can prepare the fiber 4 with multi-kernel shell structure.There is the fiber 4 of multi-kernel shell structure, each layer with its material and function to show differentiation.Optionally adopt each fluid passage 3 material, wrap up functional nano particle, medicine or cell, can be applied in the fields such as cell chulture, medicament slow release, organizational project.Relative to traditional fiber producing processes, the method that the present invention proposes, device is simple, simple operation, the designability of fiber and practicality stronger.Its concrete preparation method comprises the following steps:
(1) preparation process of micro-fluidic chip:
Utilize the method for micromachined, prepare channel network, the material of passage can select silicon or glass or the material such as polymethyl methacrylate or dimethyl silicone polymer; Or select capillary glass tube, sheet glass and syringe needle to set up microfluid coflow formula channel network.Channel network comprises three kinds of passages, is respectively fluid passage 3, continuous phase passage 2 and co-flow pathway 1, and the internal diameter size of passage is between 1 micron to 1 millimeter.
(2) preparation process of fiber:
By certain density cell or nano particle or medicine, or more any combination mixture add before aquogel in aggressiveness, vibration mixing or ultrasonic disperse, as solution.Before aquogel in fluid-phase solution, aggressiveness is selected from calcium alginate, agarose, shitosan, acrylic acid, acrylamide, N-isopropylacrylamide, Ethylene glycol dimethacrylate, polyethyleneglycol diacrylate, methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxanes methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol, or one or more the material in glycidyl methacrylate.Nanometer particle material before aquogel in aggressiveness is selected from one or more the material in silica, polystyrene, polymethyl methacrylate, titanium dioxide, iron oxide, gold, silver, fluorescent dye or quantum dot.The selection of fluid-phase solution is depended in the selection of continuous phase solution: if fluid-phase solution is oil-soluble material, continuous phase solution is selected from one or more the material in methyl-silicone oil, hexadecane, paraffin oil or soybean oil; If fluid-phase solution is water miscible material, continuous phase solution is selected from one or more the material in water, ethanol, polyvinyl alcohol, polyethylene glycol, glycerine, calcium ion salts solution, magnesium ion salting liquid or barium ions salting liquid.
Above-mentioned solution is respectively charged into syringe, connects the entrance of respective passage.Each phase solution flow rate is controlled with numerical control syringe pump, treat that fluid-phase solution presents stable threadiness in co-flow pathway 1, according to the characteristic of front oligomer solution, select ion exchange method or ultraviolet curing method or heat cure to send out method decentralized photo solution is cured, and collect at the end of co-flow pathway 1.
Embodiment 1 has the preparation of the fiber 4 of two-layer nucleocapsid structure:
1. the preparation of micro-fluidic chip:
Utilize the method for micromachined, the PDMS channel network that preparation is circular, this channel network comprises two mutual coaxial nested 3, two, fluid passage continuous phase passages 2 and a co-flow pathway 1, and each channel interior does hydrophobic treatments.
2. the preparation of fiber:
(1) configuration of each phase solution:
Fluid-phase solution 1: be that the monodisperse silica nano particle of 180 nanometers joins in the aqueous solution of polyethyleneglycol diacrylate by diameter, the mass fraction regulating silica is 40%, the mass fraction of polyethyleneglycol diacrylate is 10%, ultrasonic disperse, until colloidal particle solution produces vivid color; Initator 2-hydroxy-2-methyl propiophenone (1%, volume ratio) is added in above-mentioned solution, fully after mixing, for subsequent use after sealing.
Fluid-phase solution 2: be that the single dispersing ferriferrous oxide nano-particle of the carboxyl modified of 20 nanometers joins in the aqueous solution of polyethyleneglycol diacrylate by diameter, the mass fraction regulating four oxidation three bodies is 5%, the mass fraction of polyethyleneglycol diacrylate is 10%, ultrasonic disperse; Initator 2-hydroxy-2-methyl propiophenone (1%, volume ratio) is added in above-mentioned solution, fully after mixing, for subsequent use after sealing.
Continuous phase solution: mass fraction is the Aqueous Solutions of Polyethylene Glycol of 10%.
(2) generation of fiber and solidification
Above-mentioned solution is respectively charged into syringe, connect the entrance of respective passage, control each phase solution flow rate with numerical control syringe pump, treat that fluid-phase solution presents stable threadiness in co-flow pathway 1, by ultraviolet curing method, decentralized photo solution is cured, and collects at the end of co-flow pathway 1.
Embodiment 2 has the preparation of the fiber of the hollow structure of two-layer nucleocapsid:
1. the preparation of micro-fluidic chip:
Draw instrument with acetylene burner or microelectrode and draw three kinds of capillary glass tubies, make the tapered sharp-crested in its one end, and polish on sand paper, until sharp-crested flat smooth and the sharp-crested internal diameter of single tube is respectively 40 microns, 100 microns, 200 microns, be placed in alcohol ultrasonic cleaning, nitrogen dries up; Take sheet glass as substrate, by internal diameter be 200 microns capillary insert internal diameter be in the capillary of 580 microns, adjustment sharp-crested is on capillary axis, successively the capillary of 100 microns to be nested in the pipe of 200 microns by above-mentioned steps, the capillary of 40 microns is nested in the pipe of 100 microns, syringe needle is installed, and fixes with quick-drying gelatin.
2. the preparation of fiber:
(1) configuration of each phase solution:
Fluid-phase solution 1: configuration 2wt% sodium alginate aqueous solution, after high-temperature sterilization, equal-volume mixes with the culture medium solution of the human liver cancer cell containing 2 × 105/liter, for subsequent use after shaken well.
Fluid-phase solution 2: configuration 2wt% sodium alginate aqueous solution, after high-temperature sterilization, equal-volume becomes the culture medium solution of fiber 4 cell to mix with the mouse containing 2 × 105/liter, for subsequent use after shaken well.
Fluid-phase solution 3: configuration quality mark is the calcium chloride water of 2% respectively, mass fraction is the polyvinyl alcohol water solution of 10%, and after the mixing of the two equal-volume, high-temperature sterilization is for subsequent use.
Continuous phase solution: mass fraction is the calcium chloride water of 2%, for subsequent use after high-temperature sterilization.
(2) generation of fiber 4 and solidification
In an aseptic environment, above-mentioned solution is respectively charged into syringe, connects the entrance of respective passage, control each phase solution flow rate with numerical control syringe pump, treat that fluid-phase liquid presents stable threadiness in co-flow pathway 1, collect calcium alginate fibre at the end of co-flow pathway 1.After collection, rinse fiber with phosphate buffer and culture medium successively, finally fiber is immersed in culture medium solution and is placed in incubator.
The present invention utilizes microflow control technique, according to the 26S Proteasome Structure and Function of multi-kernel shell structure fiber, designs and builds micro-fluidic chip, by regulating composition and the flow velocity of each phase solution, can prepare the fiber with multi-kernel shell structure.There is the fiber of multi-kernel shell structure, each component with its material and function to show differentiation.Optionally adopt each fluid passage 3 material, wrap up functional nano particle, medicine or cell, can be applied in the fields such as cell chulture, medicament slow release, organizational project.Relative to traditional fiber producing processes, the method that the present invention proposes, device is simple, simple operation, the designability of fiber and practicality stronger, the parcel of nano particle of different nature, medicine or active somatic cell can be realized.
The present invention by microflow control technique, preparation there is the designability of the fiber of multi-kernel shell structure and practicality stronger.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention and accompanying drawing content to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (6)
1. prepare a method for the fiber with multi-kernel shell structure, described fiber has multi-kernel shell structure, the diameter of described fiber be 10 microns to 1 × 10
6micron, length is more than 1 millimeter, and the cross section of described fiber is circular or hollow ring, it is characterized in that, described fiber is by the preparation of micro-fluidic method, comprises the following steps:
First, micro-fluidic chip build step:
Adopt micro-processing technology to set up microfluidic channel network, or select capillary glass tube, sheet glass and syringe needle to set up microfluid c-axial channel network, this channel network comprises three kinds of passages, is respectively fluid passage, continuous phase passage and co-flow pathway; Described fluid passage is one or more, and multiple decentralized photo passage independently of one another and coaxial nested layer by layer from inside to outside;
Secondly, the preparation process of fiber:
Fluid-phase solution and continuous phase solution are respectively charged into syringe, connect respective entrance, control each phase solution flow rate with numerical control syringe pump, treat that decentralized photo presents stable threadiness in co-flow pathway, curing is, is cured the fluid liquid that mixes by physico-chemical process.
2. method according to claim 1, is characterized in that, described microfluidic channel network adopts silicon, glass, polymethyl methacrylate or dimethyl silicone polymer micro-fluid chip to make, the internal diameter size of passage be 1 micron to 1 × 10
6micron.
3. method according to claim 1, it is characterized in that, described fluid-phase solution be selected from calcium alginate, agarose, shitosan, acrylic acid, acrylamide, N-isopropylacrylamide, polyethyleneglycol diacrylate, Ethylene glycol dimethacrylate, methyl methacrylate, poly hydroxy ethyl acrylate, acetylbutyrylcellulose, siloxanes methacrylate, fluorine silicon methacrylate, perfluor ether, N-vinylpyrrolidone, polyvinyl alcohol or glycidyl methacrylate one or more.
4. method according to claim 1, is characterized in that, described fluid-phase solution is oil-soluble, described continuous phase solution be selected from methyl-silicone oil, hexadecane, paraffin oil or soybean oil one or more.
5. method according to claim 1, it is characterized in that, described fluid-phase solution is water-soluble, described continuous phase solution be selected from water, ethanol, polyvinyl alcohol, polyethylene glycol, glycerine, calcium ion salts solution, magnesium ion salting liquid or barium ions salting liquid one or more.
6. method according to claim 1, is characterized in that, the curing of described fiber select in thermal curing method, ultraviolet curing method or ion exchange method one or more.
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Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820880B (en) * | 2014-01-21 | 2016-04-20 | 东南大学 | A kind of calcium alginate fibre and preparation method thereof |
| CN103820425A (en) * | 2014-01-21 | 2014-05-28 | 东南大学 | Microfluidic device for preparing calcium alginate fibers |
| WO2016085787A1 (en) | 2014-11-25 | 2016-06-02 | Corning Incorporated | Cell culture media extending materials and methods |
| US10954609B2 (en) * | 2015-07-29 | 2021-03-23 | Dupont Safety & Construction, Inc. | Yarn from polymers having different decomposition temperatures and process for forming same |
| CN105887241B (en) * | 2016-05-27 | 2018-08-28 | 江西兄达纺织有限公司 | A kind of phase-changing and temperature-regulating chitosan composite fiber and preparation method thereof |
| CN108301070A (en) * | 2016-08-03 | 2018-07-20 | 耿云花 | A kind of preparation method of double-layer nested nanofiber |
| CN106215987B (en) * | 2016-08-12 | 2018-09-28 | 四川大学 | The controllable spinning process of multichannel cocurrent micro-fluid chip and linear multiphase heterojunction structure fiber based on the chip |
| CN107988657B (en) * | 2017-12-25 | 2019-12-10 | 东华大学 | Method for continuously preparing magnetic field responsive photonic crystal fiber |
| CN108159976A (en) * | 2018-01-03 | 2018-06-15 | 西南交通大学 | A kind of Water-In-Oil Bao Shui（W/W/O）Monodisperse double emulsion preparation method and its micro fluidic device |
| CN108360088B (en) * | 2018-02-28 | 2020-03-03 | 清华大学深圳研究生院 | Method and device for preparing calcium alginate fibers |
| CN109537071A (en) * | 2018-12-06 | 2019-03-29 | 南通纺织丝绸产业技术研究院 | A method of preparing the nanofiber of multilayered structure |
| CN109927282A (en) * | 2019-04-17 | 2019-06-25 | 中国科学院长春应用化学研究所 | A kind of Method of printing of 3D printing system and fiber |
| CN110592714B (en) * | 2019-10-09 | 2022-06-03 | 福建工程学院 | Super-tough nano-assembled cellulose filament and preparation method thereof |
| CN111549396A (en) * | 2020-05-29 | 2020-08-18 | 南京鼓楼医院 | Fiber wrapping liquid metal and preparation method thereof |
| CN112481721A (en) * | 2020-12-28 | 2021-03-12 | 南京鼓楼医院 | Microfluidic spinning device, linear type core-shell structure conductive fiber, and preparation method and application thereof |
| CN112593302A (en) * | 2020-12-28 | 2021-04-02 | 南京鼓楼医院 | Microfluidic spinning device, spiral core-shell structure conductive fiber, and preparation method and application thereof |
| CN113244438B (en) * | 2021-04-29 | 2022-05-17 | 五邑大学 | Preparation method of three-dimensional functional medical dressing for diabetic foot ulcer |
| CN113355754A (en) * | 2021-07-07 | 2021-09-07 | 中国计量大学 | Method for preparing multiphase fiber based on microfluidic-electrostatic spinning technology |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1520838A1 (en) * | 2003-09-30 | 2005-04-06 | Boehringer Ingelheim microParts GmbH | Method and apparatus for coupling hollow fibers to a microfluidical network. |
| CN1683443A (en) * | 2005-03-09 | 2005-10-19 | 哈尔滨工业大学 | Chip simply non-reversion binding method using poly dimethyl siloxanes as substrate material |
| CN102277296A (en) * | 2011-06-30 | 2011-12-14 | 复旦大学 | Proteolysis microfluidic chip based on urea resin coating and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7110646B2 (en) * | 2002-03-08 | 2006-09-19 | Lucent Technologies Inc. | Tunable microfluidic optical fiber devices and systems |
| TWI354781B (en) * | 2005-11-11 | 2011-12-21 | Laikwan Chau | Surface plasmon resonance sensing system, apparatu |
| US8552363B2 (en) * | 2007-06-21 | 2013-10-08 | Cornell University | System and method for optically driven separations using fluid filled core optical fibers |
-
2013
- 2013-03-12 CN CN201310077495.3A patent/CN103132163B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1520838A1 (en) * | 2003-09-30 | 2005-04-06 | Boehringer Ingelheim microParts GmbH | Method and apparatus for coupling hollow fibers to a microfluidical network. |
| CN1683443A (en) * | 2005-03-09 | 2005-10-19 | 哈尔滨工业大学 | Chip simply non-reversion binding method using poly dimethyl siloxanes as substrate material |
| CN102277296A (en) * | 2011-06-30 | 2011-12-14 | 复旦大学 | Proteolysis microfluidic chip based on urea resin coating and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 微流体芯片在纤维成型方面的应用研究进展;张耀鹏等;《传感器与微***》;20110120;第30卷(第1期);第1-4页 * |
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