CN103127518A - Hydrogel matrix composition and preparation method thereof - Google Patents
Hydrogel matrix composition and preparation method thereof Download PDFInfo
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- CN103127518A CN103127518A CN2011103722010A CN201110372201A CN103127518A CN 103127518 A CN103127518 A CN 103127518A CN 2011103722010 A CN2011103722010 A CN 2011103722010A CN 201110372201 A CN201110372201 A CN 201110372201A CN 103127518 A CN103127518 A CN 103127518A
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Abstract
The invention provides a hydrogel matrix composition and a preparation method thereof, and especially relates to a hydrogel matrix composition composed of sodium polyacrylate and carboxymethyl cellulose, and a preparation method thereof. A hydrogel agent prepared by the matrix composition of the invention is easy to coat, large in drug loading amount, capable of repeated uncovering and covering, convenient for patient use, good in transdermal effect, and easy to give play to drug effect.
Description
Invention field
The present invention relates to base composition of a kind of aqueous gel and preparation method thereof, relate in particular to base composition of a kind of aqueous gel that contains sodium polyacrylate and sodium carboxymethyl cellulose and preparation method thereof.
Background technology
Domestic commercially available traditional plaster externally applied ointment, mostly use natural rubber as cream base now.But because all containing the different in nature vegetable protein of sensitization in natural rubber, thus easily bring out skin allergy or cause skin irritation, and produce tearing pain when peeling off.In addition, the tradition rubber plaster needs to use large petrol as solvent in preparation process, the volatile medicine that has therapeutical effect when adopting the most gasoline of stoving process volatilization also will run off thereupon, another traditional plaster drug loading is less, transdermal effect is poor, can't repeatedly take off subsides and wait shortcomings to affect curative effect.
Along with the development of medicinal industry, pharmaceutical preparation is constantly progressive, and aqueous gel replaces traditional plaster gradually.A kind of drug loading is large, transdermal effect good in order to provide better, slow at the uniform velocity the delivery system of release, the inventor is through a large amount of practical studies, develop a kind of aqueous gel substrate that contains sodium polyacrylate and sodium carboxymethyl cellulose, can be prepared into aqueous gel after adding the medicine with therapeutical effect.
Summary of the invention
Purpose of the present invention aims to provide a kind of aqueous gel base composition that contains sodium polyacrylate and sodium carboxymethyl cellulose.Described base composition is prepared from by the component of following weight portion proportioning:
30～100 parts of sodium polyacrylate
5～20 parts of sodium carboxymethyl cellulose
15～55 parts, the mixture of gelatin, Resina persicae, tragacanth or gutta-percha any or they
2～15 parts of tween 80s
5～30 parts of azones
5～25 parts of colloidal silicas
50～180 parts of glycerol.
Wherein, sodium polyacrylate and sodium carboxymethyl cellulose are adhesive agent, and gelatin etc. can improve the denseness of the front substrate of aqueous gel molding, and improve adhesion; Add tween 80 as surfactant, can strengthen the fat-soluble medicine releasability; The promoter that azone absorbs as percutaneous, the speed of accelerating Drug Percutaneous Absorption can strengthen the amount of Drug Percutaneous Absorption simultaneously; Colloidal silica more is conducive to improve biocompatibility as adsorbent, makes aqueous gel possess the characteristic that effect is fast and the time is long.
In order to reach better effect, described base composition is prepared from by the component of following weight portion proportioning:
50～80 parts of sodium polyacrylate
10～15 parts of sodium carboxymethyl cellulose
30～40 parts, the mixture of gelatin, Resina persicae, tragacanth or gutta-percha any or they
6～10 parts of tween 80s
15～20 parts of azones
12～18 parts of colloidal silicas
90～120 parts of glycerol.
In order to reach optimum efficiency, described base composition is prepared from by the component of following weight portion proportioning:
60 parts of sodium polyacrylate
10 parts of sodium carboxymethyl cellulose
35 parts, the mixture of gelatin and Resina persicae
8 parts of tween 80s
20 parts of azones
15 parts of colloidal silicas
110 parts of glycerol.
In order to make base composition of the present invention have better performance, also can add appropriate pH adjusting agent, pH adjusting agent is selected from organic acid or mineral acid, comprises a kind of in malic acid, tartaric acid, phosphoric acid, citric acid, dilute hydrochloric acid or their mixture, preferred tartaric acid.
In order to make base composition of the present invention have best performance, also can add appropriate chelating agent in described compositions, comprise a kind of in trisodium citrate, sodium ethylene diamine tetracetate, tertiary sodium phosphate or their mixture, preferred sodium ethylene diamine tetracetate.
Another object of the present invention aims to provide a kind of preparation method of base composition of hydrogel adhesive.Described method comprises the steps:
A, weighed each raw material;
B, with tween 80 and azone mixing, add appropriate water-soluble swollen, standby;
C, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated being stirred to fully leaches, it is standby that gained is stuck with paste liquid;
D, step B and step C gained material are mixed, and fully stir mediate after, then add colloidal silica, and stir into gelling material, standby;
E, slowly add sodium polyacrylate in step D gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
The more preferably preparation method of base composition of the present invention comprises the steps:
A, weighed each raw material;
B, sodium ethylene diamine tetracetate is added appropriate water stir swelling, standby;
C, tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly the material of step B gained;
D, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated being stirred to fully leaches, it is standby that gained is stuck with paste liquid;
E, step C and step D gained material are mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material, standby;
F, slowly add sodium polyacrylate in step e gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
The best preparation method of base composition of the present invention comprises the steps:
A, by weighed each raw material of following weight portion: 8 parts, 60 parts of sodium polyacrylate, 10 parts of sodium carboxymethyl cellulose, 25 parts, gelatin, 10 parts of Resina persicaes, 8 parts of tween 80s, 20 parts of azones, 15 parts of colloidal silicas, 110 parts of glycerol, 1 part of sodium ethylene diamine tetracetate and tartaric acid;
B, sodium ethylene diamine tetracetate is added appropriate water stirred swelling approximately 1 hour, standby;
C, tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly the material of step B gained; D, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin and Resina persicae, prefabricated being stirred to fully leaches, and it is standby that gained is stuck with paste liquid;
E, step C and step D gained material are mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material, standby;
F, add sodium polyacrylate and tartaric acid in step e gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
Coat non-woven fabrics after above-mentioned aqueous gel base composition adds the medicine with therapeutical effect, the cutting section can be prepared into aqueous gel.
The every consumption per day of base composition of the present invention is 2～10g, 1～2 time on the one.
In order to verify that aqueous gel base composition of the present invention and preparation technology thereof are much better than traditional natural rubber cream and preparation technology thereof, the inventor to two kinds of handicraft products in the situation that add the same medicine component with gas chromatography determination its volatile ingredient, measure with each time point accumulation transit dose, assay method and result are as follows:
1, instrument and reagent
Japan Shimadzu GC-10A gas chromatograph, fid detector.
Reference substance: salicylic acid methanol, Borneolum Syntheticum and Camphora are middle inspection and provide.
2, chromatographic condition
Macrogol 2000 is fixative, and coating concentration is 10%, glass column: long 2 meters; The gas flow of fid detector (ml/min): nitrogen 50, hydrogen 50 and air 500.
3, method and result
The preparation of reference substance solution: precision measures methyl salicylate reference substance 0.2ml respectively, then precision takes Borneolum Syntheticum reference substance 1mg, Camphora reference substance 1mg, is placed in the 10ml volumetric flask, adds ethyl acetate and is diluted to scale, shakes up, and get final product.
The preparation of need testing solution: get substrate ointment of the present invention, each a slice of natural rubber substrate ointment, press the cutting of Franz diffusion cell dispenser mouth, Franz diffusion cell opposite side is put into 8ml diffusion liquid, in 37 ± 2 ℃ of temperature controls, again collecting absorption liquid 0.5,2,4,8 interval times, and use ethyl acetate extraction, merge, move in the 1ml volumetric flask, standby.
Sample tests: get above-mentioned sample liquid, the accurate 2 μ l that draw, calculate its content by external standard method respectively, and result is as follows:
The medicine volatile ingredient transit dose measurement result table of substrate of the present invention and natural rubber substrate
The result demonstration under identical experiment condition, is compared with the diffusibility of traditional rubber plaster, and the gel that adopts base composition of the present invention to make is much better than traditional rubber plaster; And the substrate diffusibility of the present invention that adds pH adjusting agent or chelating agent obviously is better than the pH adjusting agent that do not add or the substrate of the present invention of chelating agent.
Embodiment 1:
Take sodium polyacrylate 300g, sodium carboxymethyl cellulose 50g, gelatin 140g, Resina persicae 35g, tween 80 40g, azone 100g, colloidal silica 80g and glycerol 500g; With tween 80 and azone mixing, add appropriate water-soluble swollen, standby; Sodium carboxymethyl cellulose and glycerol are fully stirred again, and slowly add gelatin and Resina persicae, prefabricated being stirred to fully leaches, and it is standby that gained is stuck with paste liquid; Above-mentioned gained tween 80 and azone mixture are mixed with above-mentioned gained paste liquid, and after fully stirring kneading, then add colloidal silica, and stir into gelling material; At last slowly add sodium polyacrylate in the gained gelling material, and fully stir, mix homogeneously namely gets base composition of the present invention.
Above-mentioned gained base composition is added the medicine with therapeutical effect, coat on the backing base materials such as non-woven fabrics or separated type material, cutting, section can be prepared into aqueous gel 300 of the present invention and paste.
Embodiment 2:
Take sodium polyacrylate 400g, sodium carboxymethyl cellulose 80g, gelatin 160g, gutta-percha 70g, tween 80 60g, azone 120g, colloidal silica 20g, glycerol 200g and sodium ethylene diamine tetracetate 10g, sodium ethylene diamine tetracetate is added appropriate water stir swelling; Tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly in sodium ethylene diamine tetracetate swelling thing; Separately sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated be stirred to leach fully to sticking with paste aqueous; Each swelling thing of above-mentioned gained is mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material; At last slowly add sodium polyacrylate in jello, and fully stir, mix homogeneously namely gets base composition of the present invention.
Above-mentioned gained base composition is added the medicine with therapeutical effect, coat on the backing base materials such as non-woven fabrics or separated type material, cutting, section can be prepared into aqueous gel 300 of the present invention and paste.
Embodiment 3:
Take sodium polyacrylate 300g, sodium carboxymethyl cellulose 50g, gelatin 140g, Resina persicae 35g, tween 80 40g, azone 100g, colloidal silica 80g, glycerol 500g, sodium ethylene diamine tetracetate 10g and tartaric acid 30g; Tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly in sodium ethylene diamine tetracetate swelling thing; Separately sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, Resina persicae, prefabricated be stirred to leach fully to sticking with paste aqueous; Each swelling thing of above-mentioned gained is mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material; At last slowly add sodium polyacrylate and tartaric acid in jello, and fully stir, mix homogeneously namely gets base composition of the present invention.
Above-mentioned base composition is added the medicine with therapeutical effect, coat on the backing base materials such as non-woven fabrics or separated type material, cutting, section can be prepared into aqueous gel 300 of the present invention and paste.
Embodiment 4:
Take sodium polyacrylate 300g, sodium carboxymethyl cellulose 50g, gelatin 100g, tragacanth 50g, tween 80 20g, azone 25g, colloidal silica 25g, glycerol 250g, sodium ethylene diamine tetracetate 20g and malic acid 45g; Tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly in sodium ethylene diamine tetracetate swelling thing; Separately sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, the secondary glue of Calculus Bovis from Northwest of China stilbene, prefabricated be stirred to leach fully to sticking with paste aqueous; Each swelling thing of above-mentioned gained is mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material; At last slowly add sodium polyacrylate and malic acid in jello, and fully stir, mix homogeneously namely gets base composition of the present invention.
Above-mentioned gained base composition is added the medicine with therapeutical effect, coat on the backing base materials such as non-woven fabrics or separated type material, cutting, section can be prepared into aqueous gel 300 of the present invention and paste.
Embodiment 5:
Take sodium polyacrylate 350g, sodium carboxymethyl cellulose 70g, gelatin 150g, gutta-percha 20g, tween 80 30g, azone 80g, colloidal silica 60g, glycerol 450g, sodium ethylene diamine tetracetate 15g and malic acid 25g; Tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly in sodium ethylene diamine tetracetate swelling thing; Separately sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated be stirred to leach fully to sticking with paste aqueous; Each swelling thing of above-mentioned gained is mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material; At last slowly add sodium polyacrylate and malic acid in jello, and fully stir, mix homogeneously namely gets base composition of the present invention.
Above-mentioned gained base composition is added the medicine with therapeutical effect, coat on the backing base materials such as non-woven fabrics or separated type material, cutting, section can be prepared into aqueous gel 300 of the present invention and paste.
Claims (9)
1. the base composition of an aqueous gel is characterized in that described compositions is prepared from by the component of following weight portion proportioning: 50～180 parts of 5～25 parts of 5～30 parts of 2～15 parts of 15～55 parts, mixture, tween 80s, azones, the colloidal silicas of 30～100 parts of sodium polyacrylate, 5～20 parts of sodium carboxymethyl cellulose, gelatin, Resina persicae, tragacanth or gutta-percha any or they and glycerol.
2. base composition according to claim 1 is characterized in that described compositions is prepared from by the component of following weight portion proportioning: 90～120 parts of 12～18 parts of 15～20 parts of 6～10 parts of 30～40 parts, mixture, tween 80s, azones, the colloidal silicas of 50～80 parts of sodium polyacrylate, 10～15 parts of sodium carboxymethyl cellulose, gelatin, Resina persicae, tragacanth or gutta-percha any or they and glycerol.
3. base composition according to claim 1, is characterized in that described compositions is prepared from by the component of following weight portion proportioning: 110 parts of 15 parts of 20 parts of 8 parts of 35 parts, mixture, tween 80s, azones, the colloidal silicas of 60 parts of sodium polyacrylate, 10 parts of sodium carboxymethyl cellulose, gelatin and Resina persicae and glycerol.
4. the described base composition of according to claim 1 to 3 any one, it is characterized in that also can adding appropriate pH adjusting agent in described compositions, described pH adjusting agent is selected from organic acid or mineral acid, comprises a kind of in malic acid, tartaric acid, phosphoric acid, citric acid, dilute hydrochloric acid or their mixture.
5. the described base composition of according to claim 1 to 3 any one, is characterized in that also can adding appropriate chelating agent in described compositions, comprises a kind of in trisodium citrate, sodium ethylene diamine tetracetate, tertiary sodium phosphate or their mixture.
6. the preparation method of base composition claimed in claim 1, is characterized in that described method comprises the steps:
A, by described weighed each raw material of claim 1;
B, with tween 80 and azone mixing, add appropriate water-soluble swollen, standby;
C, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated being stirred to fully leaches, it is standby that gained is stuck with paste liquid;
D, step B and step C gained material are mixed, and fully stir mediate after, then add colloidal silica, and stir into gelling material, standby;
E, slowly add sodium polyacrylate in step D gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
7. the preparation method of base composition claimed in claim 5, is characterized in that described method comprises the steps:
A, by described weighed each raw material of claim 1;
B, sodium ethylene diamine tetracetate is added appropriate water stir swelling, standby;
C, tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly the material of step B gained;
D, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin, gutta-percha, prefabricated being stirred to fully leaches, it is standby that gained is stuck with paste liquid;
E, step C and step D gained material are mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material, standby;
F, slowly add sodium polyacrylate in step e gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
8. the preparation method of base composition claimed in claim 1, is characterized in that described method comprises the steps:
A, by weighed each raw material of following weight portion: 8 parts, 60 parts of sodium polyacrylate, 10 parts of sodium carboxymethyl cellulose, 25 parts, gelatin, 10 parts of Resina persicaes, 8 parts of tween 80s, 20 parts of azones, 15 parts of colloidal silicas, 110 parts of glycerol, 1 part of sodium ethylene diamine tetracetate and tartaric acid;
B, sodium ethylene diamine tetracetate is added appropriate water stirred swelling approximately 1 hour, standby;
C, tween 80 and azone mixing are added appropriate water-soluble swollen, more slowly add evenly the material of step B gained; D, sodium carboxymethyl cellulose and glycerol are fully stirred, more slowly add gelatin and Resina persicae, prefabricated being stirred to fully leaches, and it is standby that gained is stuck with paste liquid;
E, step C and step D gained material are mixed, and fully stir and mediate, then add colloidal silica, and stir into gelling material, standby;
F, add sodium polyacrylate in step e gained gelling material, and fully stir, mix homogeneously namely gets the present composition.
9. the described aqueous gel base composition of claim 1 to 8 any one, is characterized in that described compositions adds the medicine with therapeutical effect to be prepared into aqueous gel.
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| CN2011103722010A CN103127518A (en) | 2011-11-22 | 2011-11-22 | Hydrogel matrix composition and preparation method thereof |
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| CN2011103722010A CN103127518A (en) | 2011-11-22 | 2011-11-22 | Hydrogel matrix composition and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814201A (en) * | 2005-12-13 | 2006-08-09 | 上海方心科技研究所 | Chinese-medicine cataplasma for treating cervical vertebra disease and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814201A (en) * | 2005-12-13 | 2006-08-09 | 上海方心科技研究所 | Chinese-medicine cataplasma for treating cervical vertebra disease and preparing method |
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Application publication date: 20130605 |