Background technology
Current treatment blood stasis type reflux esophagitis, generally adopts: 1, omeprazole: 1. contraindication: those who are allergic to this drug, severe renal functional defect person, anemia of pregnant woman, infant patient's forbidding.2. be cautious use of: liver, renal insufficiency person, women breast-feeding their children, gerontal patient should be cautious use of.3. common adverse reactions be diarrhoea, headache, feel sick, stomachache, flatulence and constipation, accidental serum aminotransferase increases, erythra, dizzy, drowsiness, insomnia etc.; Visible chest pain, cardiopalmus, tachycardia or excessively slow, hypertension, periphery edema.Visible microscopic pyuria, albuminuria, hematuria, frequent micturition, urinary system infection, interstitial nephritis, glucose in urine, orchiodynia.Visible hemolytic anemia.Visible erubescence, dry.Rare heliosensitivity, erythema multiforme, Stevens Johnson syndrome, toxicity epidermal necrolysis, alopecia.Rare blurred vision.Rare perspiration increases, hyponatremia, gynecomastia.Rare arthralgia, myalgia, muscular strength weaken.Rare leukopenia, thrombocytopenia, agranulocytosis and pancytopenia.2, bismuth potassium citrate: 1. contraindication: those who are allergic to this drug, severe renal functional defect, anemia of pregnant woman patient's forbidding.2. be cautious use of: hepatic disfunction person, child, women breast-feeding their children are cautious use of.3. small number of patients can have slight headache, dizziness, insomnia etc.; Can there is erythra in indivedual patients; May be with ammonia taste in mouthful, and tongue, feces can be dyed to black, easily obscures mutually with tarry stool; The symptoms of digestive tract such as indivedual patients can occur feeling sick while taking, diarrhoea, constipation, loss of appetite, diarrhoea.4. long-term, high-dose is taken and may be caused Toxicity of Kidney, causes reversibility renal failure, and with 10 days in outbreak, should make regular check on renal function.5. the untoward reaction of the skeleton relevant osteoarthritis of bismuth encephalopathy (HIE) more commonly, the one-sided or both shoulders pain of often take is premonitory symptom.3, aluminium hydroxide: 1. contraindication: have strong basicity digestive juice secretion deficiency or acatharsia person, fracture patient, the hypophosphatemia patients such as bile, pancreatic juice and aluminium hydroxide allergy sufferers is forbidden.2. be cautious use of: the Acute Abdomens such as renal insufficiency person, prolonged constipation person, old people, appendicitis are cautious use of.3. can cause nausea, the symptom such as vomiting, constipation.Take in a large number for a long time, can cause serious constipation, even coproma piece causes intestinal obstruction.4. patients with renal failure long-term taking can cause encephalopathy, dementia and small cell anemia etc.4, cimetidine: 1. contraindication: anemia of pregnant woman, women breast-feeding their children's forbidding.2. be cautious use of: serious heart and respiratory system disease, chronic inflammatory disease are cautious use of as systemic lupus erythematosus (sle) (SLE), encephalosis, renal function injury, hepatic insufficiency, child.3. more common untoward reaction has diarrhoea, dizziness, weak, headache and erythra etc.; When useful agents amount is larger, can cause gynaecomastia, women's galactorrhea, hyposexuality, sexual impotence, sperm count minimizing etc., can pass through blood-cerebrospinal fluid barrier, there is certain neurotoxicity.Accidental abalienation, the untoward reaction that this product is rare has: anaphylaxis, heating, arthralgia, myalgia, granulocytopenia, thrombocytopenia, interstitial nephritis, hepatotoxicity, bradycardia, tachycardia etc.5, ranitidine: 1. contraindication: to this medicine and other H
2receptor antagonist allergy sufferers, anemia of pregnant woman, women breast-feeding their children, 8 years old following child's forbidding.2. be cautious use of: liver, renal insufficiency person, acute hematoporphyria person, old people are cautious use of.3. can occur headache, dizzy, weak, obnubilation, mental act extremely, insomnia etc.; , after accidental taking medicine, there is the mental symptoms such as disorientation, drowsiness, anxiety in liver, renal insufficiency person and gerontal patient; There is a small amount of generation blurred vision; There is constipation, diarrhoea, feel sick, vomit, suffer from abdominal pain; Can there is erythra, have only a few generation erythema multiforme; Rare arthralgia, myalgia; Rare anaphylactic reaction, shows as rubella, vasodilation, heating, bronchospasm, hypotension, anaphylactic shock, chest pain etc.; Life-time service can cause vitamin B
12lack, male breast is womanlike rare; Cause that renal dysfunction etc., quiet notes rear section patient can occur fever sensation of the face sense, dizziness, feel sick, perspiration and gastric irritation.4. this medicine has certain toxicity to liver, therefore in administration process, should monitor patient's changes of liver function.When 5. vein gives this medicine, can there is bradycardia.Therefore should be slow during quiet notes, and should make regular check on electrocardiogram in medication process.6. this medicine has certain inhibitory action to bone marrow, and the moderate leukocyte of reversibility or granulocytopenia can occur small number of patients, also occur thrombocytopenia and autoimmune hemolytic anemia.6, rabeprazole: 1. contraindication: anemia of pregnant woman, women breast-feeding their children's forbidding.2. be cautious use of: anaphylaxis or other untoward reaction persons, the patient of liver dysfunction once occurred while previously using the medicines such as lansoprazole, omeprazole, pantoprazole, gerontal patient should be cautious use of this medicine.3. visible light-sensitive reaction, erythra, pruritus, edema, visual disorder, myalgia, rhinitis.Visible xerostomia, abdominal distention, stomachache, accidentally feel sick, vomiting, constipation, diarrhoea.Rare cardiopalmus, bradycardia, chest pain.Visible dizzy, limbs fatigue, insensitive, accidental headache, rare insomnia, sleepy, grip are low, inarticulateness, lurch.Accidental blood urea nitrogen raises, albuminuria.4. use this medicine can cause erythrocyte, lymphopenia, leukopenia or increase the symptoms such as eosinophilic granulocyte, neutrophilic leukocytosis.5. use this medicine can cause the phenomenons such as propylhomoserin aminotransferase, AST, alkali phosphatase total bilirubin, T-CHOL rising.6. use this medicine likely to cover gastric cancer symptom, therefore should use this medicine on the basis of getting rid of malignant tumor.7, carbenoxolone: there is aldosterone effect, therefore can cause hypertension, water-sodium retention, low potassium alkali is poisoning and myopathy etc.Old people, hyperpietic are cautious use of, and hepatic and kidney function obstacle, recessive heart failure person avoid use.8, metoclopramide: can cause that drowsiness, weak, extrapyramidal system syndrome and spirit are uneasy etc.Not yet clear and definite on fetus impact, thus should not be for vomiting during pregnancy, and anemia of pregnant woman is cautious use of.
Summary of the invention
For overcoming above-mentioned shortcoming, the object of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of blood stasis type reflux esophagitis.
Blood stasis type reflux esophagitis refers to, due to stomach or the anti-esophagus that flows into of intestinal contents, cause the inflammation of distal esophagus mucosa.< < Medical Treasures of the Golden Chamber > > is called regurgitation.At < < vomiting sound of vomiting diarrhea, sick > > points out: " eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night, indigested food stagnated in the stomach, name is said regurgitation ".Its card be eat after, stop in stomach and do not change, towards trencherman's vomiting at night, dusk, trencherman was towards telling, and the dysphagic > > of < < Jing Yue's complete work says: " regurgitation person, eats still can enter; enter and instead go out, therefore say regurgitation.
etiology and pathogenesis:it is the higher-pressure region of long 2~5 centimetres that lower esophageal is crossed diaphragm segment, and this place's pressure is high at the bottom of compared with stomach, though it is anatomically without sphincteral structure, plays the barrier action of sphincter sample between esophagus stomach function regulating, therefore be called lower esophageal sphincter.When intragastric pressure increases, the pressure of LES is also along with increasing, to avoid stomach, the anti-esophagus that flows into of intestinal contents.LES is subject to the adjusting of vagus nerve and hormone.Drink, smoking, all can make the miopragia of LES, cause the anti-esophagus that flows to of gastrointestinal contents.So the hydrochloric acid in gastric juice and pepsin, the cholate in gallbladder, pancreatic juice and LYSOLECITHIN SUNLECITHIN A etc. can be damaged mucous membrane of esophagus, cause esophagitis.Mucous membrane of esophagus is subject to anti-stream after thing infringement, and the squamous cell on mucosa top layer comes off, and basal layer cell hypertrophy, thickens, and produces more new cell with the compensatory cells of superficial layer coming off, therefore jejune epithelial increasing proportion in mucosa.In addition, blood vessel mastoid process hypertrophy, blood tube bundle and the teleneuron of following extend, and even can reach the surface of epithelium.Because these change, the visible mucous membrane of esophagus of endoscope is hyperemia, edema, crisp and easy hemorrhage, rotten to the corn, shallow table ulcer, or with exudate, mucosa is graininess sometimes, or has white macula.Because feelings will is not smooth usually, qi depression to blood stasis, with the passing of time blood stasis forms primary disease.
clinical manifestation:while swallowing, twinge is obvious, fixingly do not move.Under normal circumstances, Esophagus has keratinization top layer, the epithelial cell attenuation on keratinization top layer or come off completely, heart burn.Burn feeling can involve to neck, interscapular region, ear, two upper arm even, and Chang Yu occurs after the meal soon, or, strenuous exercise anteflexion at trunk, lies on the back or occur during lateral position.Instead flow compared with severe one, when trunk is anteflexion or lie in bed, often have the stomach of acidity or bitterness or intestinal contents to overflow into oral cavity.Along with the progress of the course of disease, burn feeling attack times reduces, and engenders acataposis.When swallowing food, have intermittent obstruction sense, severe one can be with swallowing pain.Dark tongue quality, white and thin fur, hesitant pulse.
its technical scheme:get 9 grams of Oletum Trogopteroris, 6 grams of Radix Notoginseng, 9 grams of Radix Cirsii Japonicis, 6 grams of Flos Camelliae Japonicae, 6 grams of Herba Cirsiis, 3 grams of Herba Osbeckiaes, 6 grams of Folium Artemisiae Argyis, 9 grams of Radix et Caulis Opuntiae Dilleniis, 9 grams of Herba Agrimoniaes, 6 grams of Pseudobulbus Bletillae (Rhizoma Bletillae), 9 grams of Terra Flava Ustas, 3 grams of Crinis Carbonisatus, 3 grams, Radix Rumicis Japonici, 6 grams of Ophicalcitums, 9 grams of Radix Boehmeriaes, 9 grams of Radix Rubiae, 9 grams of Herba Salviae Plebeiaes, 6 grams of Flos althaeae roseaes, 6 grams of Herba Ecliptaes, 6 grams of Flos Caryophyllis, 6 grams of Fructus Akebiaes, 9 grams of Fructus Anisi Stellatis, 9 grams of Folium Et Cacumen Murrayae, 3 grams of Aspongopuss, 6 grams of Semen Canavaliaes, 3 grams of Radix Inulaes, 1 gram of Fructus Toosendan, 3 grams of Semen Caesalpiniae, 6 grams of the Radixs Linderae, 3 grams of Radix Et Rhizoma Nardostachyos, 3 grams of Ambra Griseas, 9 grams of Radix Curcumaes, 9 grams, Semen Persicae, 9 grams, 3 grams, Flos Carthami and Radix Glycyrrhizae, above 35 taste Chinese medicines are put into 1800 ml waters, soak 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of blood stasis type reflux esophagitis.
the advantage of this invention:we 35 taste Chinese medicine , pharmacies all can buy, and make simply, and the herb liquid toxic and side effects of making is little, short treating period, and cure rate is high.Monarch, just right.In the time of application Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine antibacterials to cause.Oletum Trogopterori, Radix Notoginseng, Radix Cirsii Japonici, Flos Camelliae Japonicae, Herba Cirsii, Herba Osbeckiae, Folium Artemisiae Argyi, Radix et Caulis Opuntiae Dillenii, Herba Agrimoniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Terra Flava Usta, Crinis Carbonisatus, Radix Rumicis Japonici, Ophicalcitum, Radix Boehmeriae, Radix Rubiae, Herba Salviae Plebeiae, Flos althaeae roseae, Herba Ecliptae, above 19 taste medical instruments have the effect of promoting blood circulation and hemostasis, spleen invigorating removing food stagnancy, promoting blood circulation and detumescence, stomach function regulating preventing or arresting vomiting, in the process for the treatment of blood stasis type reflux esophagitis, play primary treatment effect, therefore be monarch drug.Flos Caryophylli, Fructus Akebiae, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Aspongopus, Semen Canavaliae, Radix Inulae, Fructus Toosendan, Semen Caesalpiniae, the Radix Linderae, Radix Et Rhizoma Nardostachyos, Ambra Grisea, Radix Curcumae, above 13 taste medical instruments have that soothing the liver dispelling the stagnated QI, loose long-pendingization are stagnant, soothing liver-QI stomach function regulating, solution be tired of quench the thirst, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of QI to relieve pain effect.In the process for the treatment of blood stasis type reflux esophagitis, can assist principal agent performance therapeutical effect, therefore be ministerial drug.Semen Persicae: bitter, sweet, flat.Enter lung, the heart, liver, large intestine four warps.Blood circulation promoting and blood stasis dispelling, moisturizes laxation, and promoting the circulation of blood is dispeled the wind.Flos Carthami: pungent, temperature.Enter the heart, liver two warps.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, adjusts blood and blood.The all medicines of the above 2 taste medicine energy rate focus of going directly, therefore be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate again the toxicity of all medicines, therefore for making medicine.Oletum Trogopterori, Radix Notoginseng, Radix Cirsii Japonici, Flos Camelliae Japonicae, Herba Cirsii, Herba Osbeckiae, Folium Artemisiae Argyi, Radix et Caulis Opuntiae Dillenii, Herba Agrimoniae, Pseudobulbus Bletillae (Rhizoma Bletillae), Terra Flava Usta, Crinis Carbonisatus, Radix Rumicis Japonici, Ophicalcitum, Radix Boehmeriae, Radix Rubiae, Herba Salviae Plebeiae, Flos althaeae roseae, Herba Ecliptae, Flos Caryophylli, Fructus Akebiae, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Aspongopus, Semen Canavaliae, Radix Inulae, Fructus Toosendan, Semen Caesalpiniae, the Radix Linderae, Radix Et Rhizoma Nardostachyos, Ambra Grisea, Radix Curcumae, Semen Persicae, Flos Carthami, Radix Glycyrrhizae, above 35 taste medical instruments have promoting blood circulation and hemostasis, spleen invigorating removing food stagnancy, promoting blood circulation and detumescence, eliminating stasis to stop pain, dispersing cold for relieving pain, stomach function regulating preventing or arresting vomiting, soothing the liver dispelling the stagnated QI, loose long-pendingization is stagnant, soothing liver-QI stomach function regulating, separate tired quenching the thirst, the effect of promoting the circulation of QI to relieve pain, monarch, compatibility is proper, it is the optimum formula for the treatment of blood stasis type reflux esophagitis.Oletum Trogopterori: bitter, sweet, temperature.Enter liver, spleen channel.Eliminating stasis to stop pain, promoting blood circulation and hemostasis, removing toxic substances, spleen invigorating removing food stagnancy.Radix Notoginseng: sweet, micro-hardship, temperature, nontoxic.Enter liver, stomach, large intestine channel.Hemostasis dissipating blood stasis, promoting blood circulation and detumescence, eliminating stasis to stop pain.Radix Cirsii Japonici: sweet, bitter, cold.Enter the heart, Liver Channel.Cooling blood for hemostasis, removing blood stasis to reduce swelling.Flos Camelliae Japonicae: sweet, bitter, pungent, cool.Enter liver, lung, large intestine channel.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, detoxification sore treatment.Herba Cirsii: sweet, micro-hardship, cool.Enter liver, spleen, urinary bladder channel.Cooling blood for hemostasis, promoting blood circulation and detoxication, inducing diuresis for treating stranguria syndrome.Herba Osbeckiae: pungent, flat.Enter lung, large intestine, Liver Channel.Hemostasis repercussive, clearing away heat and eliminating dampness, relieving cough and asthma, blood stasis dispelling dispels the wind.Folium Artemisiae Argyi: pungent, bitter, temperature.Enter liver,spleen,kidney warp.Warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.Radix et Caulis Opuntiae Dillenii: hardship, cold.Enter the heart, lung, stomach warp.Promoting flow of QI and blood, heat-clearing and toxic substances removing, evacuation of pus granulation promoting, cooling blood for hemostasis, clearing away lung-heat to relieve cough.Herba Agrimoniae: bitter, puckery, micro-sweet, flat.Enter lung, liver, spleen, large intestine channel.Astringing to arrest bleeding, tonify deficiency dysentery relieving, parasite killing removing toxic substances, preventing the attack (or recurrence) of malaria, promoting blood circulation and detumescence.Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, be slightly cold.Enter lung, liver, stomach warp.Astringing to arrest bleeding, swollen clearly granulation promoting, parasite killing sore.Terra Flava Usta: pungent, tepor.Enter spleen, stomach, Liver Channel.Warming middle-JIAO hemostasis, stomach function regulating preventing or arresting vomiting, warming the spleen astringing intestine to stop diarrhea.Crinis Carbonisatus: hardship, flat.Enter liver, stomach warp.Hemostasis dissipating blood stasis, nourishing YIN diuresis, promoting tissue regeneration and ulcer healing.Radix Rumicis Japonici: hardship, cold, mild toxicity.Enter spleen, liver, large intestine, urinary bladder channel.Cooling blood for hemostasis, parasite killing are treated tinea, expelling pathogenic heat to loosen the bowels.Ophicalcitum: sour, puckery, flat.Enter Liver Channel.Astringing to arrest bleeding, hemostasis by removing blood stasis.Radix Boehmeriae: sweet, cold.Enter the heart, Liver Channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing, clearing heat and preventing abortion, clearing away heat and promoting diuresis.Radix Rubiae: bitter, salty, sour, cold.Enter liver, the heart, spleen, stomach, lung meridian.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, dispelling wind dredging collateral, heat clearing away jaundice eliminating, eliminating phlegm and stopping cough.Herba Salviae Plebeiae: pungent, bitter, cool.Enter the heart, liver, kidney channel.Cooling blood for hemostasis, inducing diuresis to remove edema, removing toxic substances parasite killing.Flos althaeae roseae: sweet, salty, cold, nontoxic.Enter spleen, stomach, kidney channel.Promoting blood circulation and hemostasis, clearing away heat-damp and promoting diuresis, moistening dryness for relaxing bowels, detoxicating and resolving stagnation of pathogens.Herba Ecliptae: sweet, sour, cool.Enter liver, kidney, stomach, large and small intestinal warp.Cooling blood for hemostasis, yin nourishing black hair, removing dampness to relieve itching.Flos Caryophylli: pungent, temperature.Enter spleen, stomach, kidney channel.Warming middle-JIAO to send down the adverse QI, warming the kidney tonifying YANG, promoting the circulation of QI to relieve pain, consciousness and resuscitation restoring, wards off dirty parasite killing.Fructus Akebiae: sweet, cold.Enter liver, stomach warp.Soothing liver-QI stomach function regulating, promoting blood circulation and stopping pain, inducing diuresis for treating stranguria syndrome, separates tired quenching the thirst.Fructus Anisi Stellati: acrid, sweet, warm.Enter liver,kidney,spleen, stomach warp.Warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, warming and recuperating the kidney-YANG, wards off evil dirt eliminating.Folium Et Cacumen Murrayae: pungent, bitter, temperature.Enter the heart, liver, lung meridian.Promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, expelling wind and removing dampness, hard masses softening and resolving.Aspongopus: salty, sweet, temperature, nontoxic.Enter liver,spleen,kidney warp.Promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG, warming middle-JIAO to stop diarrhea.Semen Canavaliae: sweet, flat, nontoxic.Enter spleen, stomach, large intestine, kidney channel.Warming the middle warmer and descending qi, kidney tonifying complement, eliminating phlegm and relieving asthma, promoting the circulation of QI to relieve pain.Radix Inulae: pungent, bitter, temperature.Enter lung, liver, spleen channel.Invigorating the spleen and regulating the stomach, promoting the circulation of QI to relieve pain, get rid of evils and control algid malaria, peace ascarifuge.Fructus Toosendan: hardship, cold, slightly poisonous.Enter liver, stomach, small intestinal, urinary bladder channel.Removing dampness and killing parasites, promoting the circulation of QI to relieve pain, clearing heat, purging intense-heat.Semen Caesalpiniae: pungent, temperature.Enter lung, large intestine channel.Promoting the circulation of QI to relieve pain, preventing the attack (or recurrence) of malaria, only quenches one's thirst.The Radix Linderae: pungent, temperature.Enter lung, spleen, kidney, urinary bladder channel.Promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.Radix Et Rhizoma Nardostachyos: acrid, sweet, warm.Enter spleen, stomach warp.Promoting the circulation of QI to relieve pain, activating spleen and strengthening stomach, removing dampness is drawn out pus by applying a plaster to the affected part.Ambra Grisea: sweet, sour, gas raw meat, tepor.Enter the heart, lung, liver, kidney channel.Promoting flow of QI and blood, relieving stranguria by diuresis, relieving cough and asthma, promotes the production of body fluid and is full of cheek, wards off dirty removing toxic substances.Radix Curcumae: pungent, bitter, cold.Enter the heart, lung, liver, gallbladder meridian.Circulation of qi promoting blood stasis dispelling, heart fire-clearing upset-relieving, cooling blood for hemostasis.Semen Persicae: bitter, sweet, flat.Enter lung, the heart, liver, large intestine four warps.Blood circulation promoting and blood stasis dispelling, moisturizes laxation, and promoting the circulation of blood is dispeled the wind.Flos Carthami: pungent, temperature.Enter the heart, liver two warps.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, adjusts blood and blood.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.